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https://www.readbyqxmd.com/read/27897967/an-observational-study-of-donor-ex-vivo-lung-perfusion-in-uk-lung-transplantation-develop-uk
#1
Andrew Fisher, Anders Andreasson, Alexandros Chrysos, Joanne Lally, Chrysovalanto Mamasoula, Catherine Exley, Jennifer Wilkinson, Jessica Qian, Gillian Watson, Oli Lewington, Thomas Chadwick, Elaine McColl, Mark Pearce, Kay Mann, Nicola McMeekin, Luke Vale, Steven Tsui, Nizar Yonan, Andre Simon, Nandor Marczin, Jorge Mascaro, John Dark
BACKGROUND: Many patients awaiting lung transplantation die before a donor organ becomes available. Ex vivo lung perfusion (EVLP) allows initially unusable donor lungs to be assessed and reconditioned for clinical use. OBJECTIVE: The objective of the Donor Ex Vivo Lung Perfusion in UK lung transplantation study was to evaluate the clinical effectiveness and cost-effectiveness of EVLP in increasing UK lung transplant activity. DESIGN: A multicentre, unblinded, non-randomised, non-inferiority observational study to compare transplant outcomes between EVLP-assessed and standard donor lungs...
November 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27862972/long-term-medical-and-psychosocial-outcomes-in-living-liver-donors
#2
Mary Amanda Dew, Zeeshan Butt, Abhinav Humar, Andrea F DiMartini
Due to the enduring organ shortage, living donor liver transplantation has been a valuable treatment strategy for advanced liver disease patients for over 20 years. A variety of reviews have summarized the extensive data now available on medical and psychosocial risks to living donors in the aftermath of donation. However, evidence on donor medical and psychosocial outcomes beyond the first year postdonation has not been synthesized in any previous review. The evidence base on such "long-term" outcomes has been growing in recent years...
November 10, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27805505/challenges-for-renal-retransplant-an-overview
#3
Mohamed Adel Bakr, Ahmed Abdelfattah Denewar, Mohamed Hamed Abbas
Despite many achievements in renal transplant in the past few years regarding immunosuppression and tissue matching, the rates of early and late graft loss and return to dialysis are still high. Many of those with primary graft failure will be listed for a kidney retransplant, as this allows for better quality of life than dialysis. Many challenges face those requiring renal retransplant, including first graft nephrectomy and whether site of retransplant should be ipsilateral or contralateral, whether to conduct preemptive retransplant or wait while on dialysis, additional immunologic factors, immunosuppression after retransplant, cancer risk, BK virus infection, and retransplant in pediatrics...
November 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27802832/reproductive-issues-in-patients-undergoing-hematopoietic-stem-cell-transplantation-an-update
#4
REVIEW
Maurizio Guida, Maria Antonietta Castaldi, Rosa Rosamilio, Valentina Giudice, Francesco Orio, Carmine Selleri
In 1963 George Mathé announced to the world that he had cured a patient of leukaemia by means of a bone-marrow transplant. Since than much progress has been made and nowadays Hematopoietic Stem Cell Transplantation (HSCT) is considered the most effective treatment of numerous severe haematological diseases. Gynaecological complications in HSCT women represent a serious concern for these patients, but often underestimated by clinicians in the view of Overall Survival. The main gynaecological complications of HSCT are represented by: premature ovarian failure (POF), thrombocytopenia-associated menorrhagia, genital symptoms or sexual problems in course of chronic GVHD (cGVHD), osteoporosis, secondary solid tumours due to immunosuppressive drugs to treat cGVHD and severity of cGVHD, and fertility and pregnancy issues...
November 1, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27798034/rationale-and-design-of-platelet-transfusions-in-haematopoietic-stem-cell-transplantation-the-path-pilot-study
#5
Jason Tay, David Allan, Sara Beattie, Christopher Bredeson, Dean Fergusson, Dawn Maze, Mitchell Sabloff, Kednapa Thavorn, Alan Tinmouth
INTRODUCTION: In patients with transient thrombocytopenia being treated with high-dose chemotherapy followed by stem cell rescue-haematopoietic stem cell transplantation (HSCT), prophylactic transfusions are standard therapy to prevent bleeding. However, a recent multicentre trial suggests that prophylactic platelet transfusions in HSCT may not be necessary. Additionally, the potential overuse of platelet products places a burden on a scarce healthcare resource. Moreover, the benefit of prophylactic platelet transfusions to prevent clinically relevant haemorrhage is debatable...
October 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27788795/physical-symptoms-and-associated-factors-in-chinese-renal-transplant-recipients
#6
H Wei, Z Guan, J Zhao, W Zhang, H Shi, W Wang, J Wang, X Xiao, Y Niu, B Shi
OBJECTIVE: This study aimed to investigate physical symptoms in renal transplant recipients as well as the correlation between self-efficacy and symptom distress. METHODS: A total of 274 consecutive renal transplant recipients were enrolled using a convenience sampling method. The basic characteristics of renal transplant recipients were collected using a general situation questionnaire. Physical symptom distress and self-efficacy were assessed by the Kidney Transplant Questionnaire and the Perceived Health Competence Scale, respectively...
October 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27751935/health-related-quality-of-life-among-older-related-hematopoietic-stem-cell-donors-60-years-is-equivalent-to-that-of-younger-related-donors-18-to-60-years-a-related-donor-safety-study
#7
Galen E Switzer, Jessica Bruce, Deidre M Kiefer, Hati Kobusingye, Rebecca Drexler, RaeAnne M Besser, Dennis L Confer, Mary M Horowitz, Roberta J King, Bronwen E Shaw, Marcie Riches, Brandon Hayes-Lattin, Michael Linenberger, Brian Bolwell, Scott D Rowley, Mark R Litzow, Michael A Pulsipher
The increasing number of older adults with blood-related disorders and the introduction of reduced-intensity conditioning regimens has led to increases in hematopoietic stem cell (HSC) transplantation among older adults and a corresponding increase in the age of siblings who donate HSCs to these patients. Data regarding the donation-related experiences of older donors are lacking. The Related Donor Safety Study aimed to examine/compare health-related quality of life (HRQoL) of older versus younger HSC donors...
October 14, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27743488/the-effect-of-lung-transplantation-on-health-related-quality-of-life-in-the-era-of-the-lung-allocation-score-a-u-s-prospective-cohort-study
#8
Jonathan P Singer, Patricia P Katz, Allison Soong, Pavan Shrestha, Debbie Huang, Jennifer Ho, Malori Mindo, John R Greenland, Steven R Hays, Jeffrey Golden, Jasleen Kukreja, Mary Ellen Kleinhenz, Rupal J Shah, Paul D Blanc
Under the U.S. Lung Allocation Score (LAS) system, older and sicker patients are prioritized for lung transplantation (LT). The impact of these changes on health-related quality of life (HRQL) after transplant has not been determined. In a single-center prospective cohort study, from 2010-2016 we assessed HRQL before and repeatedly after LT for up to 3 years using the SF12-Physical and Mental Health, the respiratory-specific Airway Questionnaire 20-Revised, and the Euroqol 5D/Visual Analog Scale utility measures by multivariate linear mixed models jointly modeled with death...
October 15, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27727093/-lower-urinary-tract-symptoms-and-pelvic-floor-dysfunction-in-renal-transplant-candidates-and-recipients
#9
R Thuret, S Hurel, F Kleinclauss, M O Timsit
OBJECTIVES: To describe lower urinary tract symptoms (LUTS) and their management in renal transplant candidates and recipients. MATERIAL AND METHODS: Relevant publications were identified through Medline (http://www.ncbi.nlm.nih.gov) and Embase (http://www.embase.com) database using the following keywords, alone or in association: "transplantation", "prostate hyperplasia", "transurethral resection of prostate", "urinary incontinence", "LUTS", "pelvic floor dysfunction"...
October 7, 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27716318/reliability-and-validity-of-the-chinese-mandarin-version-of-pedsql%C3%A2-3-0-transplant-module
#10
Ying Chang, Yanhui Luo, Yuchen Zhou, Ruixin Wang, Na Song, Guanghua Zhu, Bin Wang, Maoquan Qin, Jun Yang, Yuan Sun, Chunfu Li, Xuan Zhou
BACKGROUND: Long-term health-related quality of life (HRQoL) of pediatric patients after hematopoietic stem cell transplantation (HSCT) is increasingly studied worldwide. However, few studies have been performed in China, where no uniform scale is available; the PedsQL™ Cancer Module 3.0 Chinese Mandarin version has been used to evaluate HRQoL of patients after HSCT in China. This study aimed to assess the reliability and validity of the Chinese Mandarin version of PedsQL™ 3.0 Transplant Module...
October 5, 2016: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/27706804/bisphosphonates-for-steroid-induced-osteoporosis
#11
REVIEW
Claire S Allen, James Hs Yeung, Ben Vandermeer, Joanne Homik
BACKGROUND: This is an update of a Cochrane Review first published in 1999. Corticosteroids are widely used in inflammatory conditions as an immunosuppressive agent. Bone loss is a serious side effect of this therapy. Several studies have examined the use of bisphosphonates in the prevention and treatment of glucocorticosteroid-induced osteoporosis (GIOP) and have reported varying magnitudes of effect. OBJECTIVES: To assess the benefits and harms of bisphosphonates for the prevention and treatment of GIOP in adults...
October 5, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27662885/health-related-quality-of-life-across-all-stages-of-autosomal-dominant-polycystic-kidney-disease
#12
Daniel Eriksson, Linda Karlsson, Oskar Eklund, Hans Dieperink, Eero Honkanen, Jan Melin, Kristian Selvig, Johan Lundberg
BACKGROUND: A limited number of studies have assessed health-related quality of life (HRQoL) in autosomal dominant polycystic kidney disease (ADPKD). Results to date have been conflicting and studies have generally focused on patients with later stages of the disease. This study aimed to assess HRQoL in ADPKD across all stages of the disease, from patients with early chronic kidney disease (CKD) to patients with end-stage renal disease. METHODS: A study involving cross-sectional patient-reported outcomes and retrospective clinical data was undertaken April-December 2014 in Denmark, Finland, Norway and Sweden...
September 23, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27624504/glucose-fluctuations-reduce-quality-of-sleep-and-of-life-in-patients-with-liver-cirrhosis
#13
Masafumi Haraguchi, Hisamitsu Miyaaki, Tatsuki Ichikawa, Hidetaka Shibata, Takuya Honda, Eisuke Ozawa, Satoshi Miuma, Naota Taura, Fuminao Takeshima, Kazuhiko Nakao
BACKGROUND: Sleep disturbance and decreased health-related quality of life (HRQOL) are significant complaints in patients with liver cirrhosis. Although the etiology of these complications is unclear, we propose that glucose intolerance may be a predisposing factor. Therefore, our aim was to investigate the relationship between glucose intolerance and these complications. METHODS: We assessed continuous glucose monitoring in 43 patients with chronic liver disease...
September 13, 2016: Hepatology International
https://www.readbyqxmd.com/read/27618687/a-resilience-intervention-involving-mindfulness-training-for-transplant-patients-and-their-caregivers
#14
Cynthia M Stonnington, Betty Darby, Angela Santucci, Pamela Mulligan, Patricia Pathuis, Andrea Cuc, Joseph G Hentz, Nan Zhang, David Mulligan, Amit Sood
Solid organ and stem cell transplant patients and their caregivers report a substantial level of distress. Mindfulness-based stress reduction has been shown to alleviate distress associated with transplant, but there is limited experience in this population with other mindfulness-based interventions, or with combined transplant patient and caregiver interventions. We evaluated a novel, 6-week mindfulness-based resilience training (MBRT) class for transplant patients and their caregivers that incorporates mindfulness practice, yoga, and neuroscience of stress and resilience...
November 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/27590836/public-health-impact-of-comprehensive-hepatitis-c-screening-and-treatment-in-the-french-baby-boomer-population
#15
Olivier Ethgen, Yuri Sanchez Gonzalez, Grégoire Jeanblanc, Aurore Duguet, Derek Misurski, Timothy Juday
OBJECTIVE: To estimate the public health impact of comprehensive hepatitis C virus (HCV) screening and access to all-oral, interferon (IFN)-free direct-acting antivirals (DAAs) in the French baby-boomer population (1945-1965 birth cohorts). METHODS: A sequential, multi-cohort, health-state transition model was developed to assess the impact of different hepatitis C screening and treatment strategies on clinical and economic outcomes in the 1945-1965 birth cohorts...
September 2, 2016: Journal of Medical Economics
https://www.readbyqxmd.com/read/27578428/immunosuppressive-therapy-for-kidney-transplantation-in-adults-a-systematic-review-and-economic-model
#16
Tracey Jones-Hughes, Tristan Snowsill, Marcela Haasova, Helen Coelho, Louise Crathorne, Chris Cooper, Ruben Mujica-Mota, Jaime Peters, Jo Varley-Campbell, Nicola Huxley, Jason Moore, Matt Allwood, Jenny Lowe, Chris Hyde, Martin Hoyle, Mary Bond, Rob Anderson
BACKGROUND: End-stage renal disease is a long-term irreversible decline in kidney function requiring renal replacement therapy: kidney transplantation, haemodialysis or peritoneal dialysis. The preferred option is kidney transplantation, followed by immunosuppressive therapy (induction and maintenance therapy) to reduce the risk of kidney rejection and prolong graft survival. OBJECTIVES: To review and update the evidence for the clinical effectiveness and cost-effectiveness of basiliximab (BAS) (Simulect(®), Novartis Pharmaceuticals UK Ltd) and rabbit anti-human thymocyte immunoglobulin (rATG) (Thymoglobulin(®), Sanofi) as induction therapy, and immediate-release tacrolimus (TAC) (Adoport(®), Sandoz; Capexion(®), Mylan; Modigraf(®), Astellas Pharma; Perixis(®), Accord Healthcare; Prograf(®), Astellas Pharma; Tacni(®), Teva; Vivadex(®), Dexcel Pharma), prolonged-release tacrolimus (Advagraf(®) Astellas Pharma), belatacept (BEL) (Nulojix(®), Bristol-Myers Squibb), mycophenolate mofetil (MMF) (Arzip(®), Zentiva; CellCept(®), Roche Products; Myfenax(®), Teva), mycophenolate sodium (MPS) (Myfortic(®), Novartis Pharmaceuticals UK Ltd), sirolimus (SRL) (Rapamune(®), Pfizer) and everolimus (EVL) (Certican(®), Novartis) as maintenance therapy in adult renal transplantation...
August 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27571924/survival-and-complication-rates-in-patients-with-thalassemia-major-in-taiwan
#17
Han-Ping Wu, Cheng-Li Lin, Yin-Chen Chang, Kang-Hsi Wu, Rouh-Lih Lei, Ching-Tien Peng, Tefu Weng, Yu-Man Tai, Yu-Hua Chao
BACKGROUND: While transfusion and iron chelation therapy for thalassemia major (TM) has improved dramatically in recent years, the consequences of this improvement (current rates of survival and TM-related complications) remain unknown. METHODS: This nationwide population-based cohort study analyzed 2007-2011 data obtained from the Taiwanese National Health Insurance Research Database. RESULTS: After excluding those patients receiving hematopoietic stem cell transplantation, we enrolled 454 patients with TM who received transfusion and chelation therapy (median age, 17...
August 30, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27569954/health-related-quality-of-life-and-psychological-distress-in-patients-with-early-stage-hepatocellular-carcinoma-after-hepatic-resection-or-transplantation
#18
J Y Lei, L N Yan, W T Wang, J Q Zhu, D J Li
BACKGROUND: The aim of our study was to compare the post-operative health-related quality of life in patients with small hepatocellular carcinoma (HCC; within the Milan criteria) after liver resection or liver transplantation. METHODS: From August 2000 to December 2010, 207 patients were diagnosed with early HCC within the Milan criteria. We divided these patients into 2 groups according to their curative schedule: the liver transplantation group (n = 95) and the liver resection group (n = 110)...
July 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27567680/face-transplant-long-term-follow-up-and-results-of-a-prospective-open-study
#19
COMMENT
Laurent Lantieri, Philippe Grimbert, Nicolas Ortonne, Caroline Suberbielle, Dominique Bories, Salvador Gil-Vernet, Cédric Lemogne, Frank Bellivier, Jean Pascal Lefaucheur, Nathaniel Schaffer, Fréderic Martin, Jean Paul Meningaud, Pierre Wolkenstein, Mikael Hivelin
BACKGROUND: More than 30 face transplantations have been done worldwide since 2005 but no documented long-term follow-up has been reported in the literature. We aimed to answer remaining question about the long-term risks and benefits of face transplant. METHODS: In this single-centre, prospective, open study, we assessed 20 patients presenting with facial defects. Ten patients were selected, and, after three were secondarily excluded, seven were transplanted: two with neurofibromatosis 1, one with a burn, and four with self-inflicted facial gunshot injuries...
October 1, 2016: Lancet
https://www.readbyqxmd.com/read/27567048/physical-function-after-extracorporeal-membrane-oxygenation-in-patients-pre-or-post-heart-transplantation-an-observational-study
#20
Kate Hayes, Anne E Holland, Vincent A Pellegrino, Angeline S Leet, Louise M Fuller, Carol L Hodgson
OBJECTIVE: To describe physical function, leg complications and health-related quality of life (HRQOL) in the three months following extracorporeal membrane oxygenation (ECMO) pre- or post-heart transplantation (HTx). BACKGROUND: Little is known about functional recovery following ECMO before or after HTx. METHODS: A 2-year retrospective study in patients who received ECMO pre or post HTx. Strength, mobility, leg complications and HRQOL were recorded to hospital discharge...
August 23, 2016: Heart & Lung: the Journal of Critical Care
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