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https://www.readbyqxmd.com/read/29776756/sex-hormone-binding-globulin-is-a-biomarker-associated-with-nonvertebral-fracture-in-men-on-dialysis-therapy
#1
Jasna Aleksova, Phillip Wong, Robert McLachlan, Kay Weng Choy, Peter R Ebeling, Frances Milat, Grahame J Elder
Gonadal hormones impact bone health and higher values of sex hormone-binding globulin (SHBG) have been independently associated with fracture risk in men without chronic kidney disease. People with chronic kidney disease have a greatly increased fracture risk, and gonadal dysfunction is common in men receiving dialysis treatment. Nevertheless, in these men the effect of gonadal steroids and SHBG on bone mineral density (BMD) and fracture risk is unknown. Here we investigate relationships between gonadal steroids, SHBG, BMD and fracture in men on long-term dialysis therapy, awaiting kidney or simultaneous pancreas kidney transplantation...
May 15, 2018: Kidney International
https://www.readbyqxmd.com/read/29775762/aortic-vascular-calcification-is-inversely-associated-with-the-trabecular-bone-score-in-patients-receiving-dialysis
#2
Jasna Aleksova, Samantha Kurniawan, Mirna Vucak-Dzumhur, Peter Kerr, Peter R Ebeling, Frances Milat, Grahame J Elder
INTRODUCTION: Progressive chronic kidney disease (CKD) confers a marked increase in risk for vascular calcification, cardiovascular disease, fracture and mortality, with likely contributing factors including dysregulated bone metabolism and mineral homeostasis. In general population studies, increased vascular calcification is directly related to mortality and inversely related to bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA). In patients with CKD, abnormalities in turnover, mineralization and bone volume, reduce the ability of DXA to predict fracture...
May 15, 2018: Bone
https://www.readbyqxmd.com/read/29772613/safety-of-dual-kidney-transplantation-compared-to-single-kidney-transplantation-from-expanded-criteria-donors-a-single-center-cohort-of-39-recipients
#3
Lionel Mendel, Laetitia Albano, Imad Bentellis, Thierry Yandza, Caroline Bernardi, Herve Quintens, Brannwel Tibi, Jacques Jourdan, Matthieu Durand, Jean Amiel, Daniel Chevallier
Our objective was to compare outcomes of DKT to single kidney transplantation (SKT) performed with grafts from expanded criteria donors (ECD) in recipients ≥65 years, focusing on surgical complications. All kidney transplantations (KT) performed between 2006 and 2014 in our institution were analyzed. DKT were indicated according to the criteria of the French national Agence de la Biomedecine. Thirty-nine DKT and 155 SKT were included, with a median follow-up of 36 and 26.5 months, respectively. The rate of early surgical revisions was not significantly higher after DKT (23...
May 17, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29725634/bowman-capsule-volume-and-related-factors-in-adults-with-normal-renal-function
#4
Takaya Sasaki, Nobuo Tsuboi, Kotaro Haruhara, Yusuke Okabayashi, Go Kanzaki, Kentaro Koike, Akimitsu Kobayashi, Izumi Yamamoto, Makoto Ogura, Takashi Yokoo
Introduction: Alterations in glomerular filtration can considerably influence the dynamics and functions of the Bowman capsule. Despite the potentially important role in maintaining normal renal functions, few studies have focused on Bowman capsule volume in normal human kidneys. Methods: We analyzed specimens from biopsies performed 1 hour after kidney transplantation from living donors without apparent renal disease. The measurements of all cross-sectional areas of the Bowman capsules and glomerular capillaries were used to estimate the mean Bowman capsule volume (BV) and glomerular capillary volume (GV) in each subject...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29709320/reactivation-of-hepatitis-b-virus-in-kidney-transplant-recipients-with-previous-clinically-resolved-infection-a-single-center-experience
#5
Catarina Meng, Carolina Belino, Luciano Pereira, Ana Pinho, Susana Sampaio, Isabel Tavares, Manuela Bustorff, António Sarmento, Manuel Pestana
BACKGROUND: Hepatitis B virus (HBV) reactivation in kidney transplant recipients (KTR) involves important morbidity and mortality. Despite being more common in patients who are HBsAg-positive, it may occur in patients with clinically resolved infection (HBsAg-negative and anti-HBc-positive), in whom the presence of the protective anti-HB antibody is thought to decrease the risk of reactivation. Data regarding reactivation rates in this population are scarce. OBJECTIVE: To retrospectively evaluate the risk of HBV reactivation in KTR with previously resolved infection...
April 27, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29707619/differences-in-proinflammatory-cytokines-and-monocyte-subtypes-in-older-as-compared-with-younger-kidney-transplant-recipients
#6
Emily C Liang, Maura Rossetti, Tiffany Sidwell, Victoria Groysberg, Gema Sunga, Yael Korin, Sitaram Vangala, Basmah Abdalla, Erik Lum, Suphamai Bunnapradist, Phuong-Thu Pham, Gabriel Danovitch, Elaine F Reed, Joanna Schaenman
Background: The number of elderly patients with end-stage kidney disease requiring kidney transplantation continues to grow. Evaluation of healthy older adults has revealed proinflammatory changes in the immune system, which are posited to contribute to age-associated illnesses via "inflamm-aging." Immunologic dysfunction is also associated with impaired control of infections. Whether these immunologic changes are found in older kidney transplant recipients is not currently known, but may have important implications for risk for adverse clinical outcomes...
March 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29617898/assessment-of-the-kidney-donor-profile-index-in-a-european-cohort
#7
Lukas Johannes Lehner, Anna Kleinsteuber, Fabian Halleck, Dmytro Khadzhynov, Eva Schrezenmeier, Michael Duerr, Kai-Uwe Eckardt, Klemens Budde, Oliver Staeck
Background: Recently, transplant societies have had to change their allocation policies to counter global organ shortages. However, strategies differ significantly and long-term outcomes and cross-regional applicability remain to be evaluated. Methods: Therefore, we retrospectively analysed the Kidney Donor Profile Index (KDPI) of 987 adult kidney transplants at our centre using data from the Organ Procurement and Transplantation Network (OPTN) as a reference. Results: In our cohort, the median KDPI was 66%, with a higher proportion of >85% KDPI kidneys compared with the US cohort (32...
March 30, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29579876/orthotopic-liver-transplantation-preliminary-analysis-of-complications-with-grafts-from-elderly-donors
#8
J R Naranjo-Izurieta, Z Ruiz de Azúa-López, J Lameirao, L Martín-Villén, A Roldán-Reina, M Porras-López, A Rodríguez-Rodríguez, J J Egea-Guerrero
OBJECTIVE: This study aims to determine if donor grafts of patients older than 65 years develop more post-transplantation complications than those of younger patients. DESIGN: This is a retrospective, observational study of liver transplant recipients during 12 months in Virgen del Rocio University Hospital. We compare incidence rates of reperfusion syndrome, acute kidney injury, and need for intra- and postoperative red blood cell transfusions in two donor age groups in which group A is <65 years old and group B is ≥65 years old...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29556678/the-trabecular-bone-score-is-associated-with-bone-mineral-density-markers-of-bone-turnover-and-prevalent-fracture-in-patients-with-end-stage-kidney-disease
#9
J Aleksova, S Kurniawan, G J Elder
Fracture risk increases in end-stage kidney disease (ESKD), but bone mineral density (BMD) measurement is less predictive of risk than in the general population. In this study of patients with ESKD, a lower trabecular bone score (TBS), indicative of microarchitectural deterioration, was associated with higher bone turnover markers and prevalent non-vertebral fracture. INTRODUCTION: Declining renal function carries increased fracture risks, but BMD is less predictive of fracture for dialysis patients than the general population...
March 19, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29501679/personalized-immunosuppression-in-elderly-renal-transplant-recipients
#10
REVIEW
L E J Peeters, L M Andrews, D A Hesselink, B C M de Winter, T van Gelder
The number of elderly people has increased considerably over the last decades, due to a rising life expectancy and ageing populations. As a result, an increased number of elderly with end-stage-renal-disease are diagnosed, for which the preferred treatment is renal transplantation. Over the past years the awareness of the elderly as a specific patient population has grown, which increases the importance of research in this group. Elderly patients often receive kidneys from elderly donors while younger donor kidneys are preferentially reserved for younger recipients...
April 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29490298/mortality-in-elderly-waiting-list-patients-versus-age-matched-kidney-transplant-recipients-where-is-the-risk
#11
Domingo Hernández, Juana Alonso-Titos, Ana María Armas-Padrón, Pedro Ruiz-Esteban, Mercedes Cabello, Verónica López, Laura Fuentes, Cristina Jironda, Silvia Ros, Tamara Jiménez, Elena Gutiérrez, Eugenia Sola, Miguel Angel Frutos, Miguel González-Molina, Armando Torres
The number of elderly patients on the waiting list (WL) for kidney transplantation (KT) has risen significantly in recent years. Because KT offers a better survival than dialysis therapy, even in the elderly, candidates for KT should be selected carefully, particularly in older waitlisted patients. Identification of risk factors for death in WL patients and prediction of both perioperative risk and long-term post-transplant mortality are crucial for the proper allocation of organs and the clinical management of these patients in order to decrease mortality, both while on the WL and after KT...
2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29453878/estimated-glomerular-filtration-rate-in-stable-older-kidney-transplant-recipients-are-present-algorithms-valid-a-national-cross-sectional-cohort-study
#12
Kristian Heldal, Karsten Midtvedt, Anders Hartmann, Anna Varberg Reisaeter, Torbjørn F Heldal, Stein Bergan, Cathrin L Salvador, Anders Åsberg
Several equations have been developed for estimated glomerular filtration rate (eGFR) in patients with chronic kidney disease (CKD), but none were developed based on data from elderly kidney transplant recipients (KTR). The primary aim of this study was to evaluate different creatinine-based equations in stable elderly KTR. A national cross-sectional study was performed using data from 263 consecutive kidney transplant recipients 60 years or older who performed a routine GFR measurement one year after engraftment...
February 17, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29407306/short-term-results-of-liver-transplantation-with-octogenarian-donors
#13
L Gajate Martín, A Martín Grande, D Parise Roux, C González Cibrián, C Fernández Martín, M A Rodríguez Gandía, A López Buenadicha
BACKGROUND: There are increasingly more patients awaiting liver transplantation while the number of donors has remained stable. It has been proven that grafts from donors older than 60 years have comparable results with those from younger donors. It is unclear whether this is so with donors older than 80 years old. MATERIAL AND METHODS: This was a retrospective study of all adult liver transplantations at our institution between March 2011 and December 2015. We compared 1-, 3-, 6-, and 12-month graft survival rates from donors <80 years and ≥80 years...
January 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29385883/successful-use-of-cytarabine-and-bendamustine-in-a-patient-with-mantle-cell-lymphoma-and-acute-renal-failure-using-intermittent-hemodialysis-a-case-report
#14
Matthew Ettleson, Kale S Bongers, Kaitlyn Vitale, Anthony J Perissinotti, Tycel Phillips, Bernard L Marini
Mantle cell lymphoma is a mature B-cell non-Hodgkin lymphoma characterized by the hallmark (11;14) chromosomal translocation, which often presents with lymphadenopathy and extra-nodal involvement. Young, fit patients are generally treated with chemotherapy approaches that incorporate high-dose cytarabine (e.g. the Nordic regimen) followed by autologous hematopoietic cell transplantation. Because of the significant activity of cytarabine in mantle cell lymphoma, increasingly, high- and intermediate-dose cytarabine are being used in the treatment of elderly mantle cell lymphoma patients...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29363863/acute-hypocalcaemia-following-denosumab-in-heart-and-lung-transplant-recipients-with-osteoporosis
#15
Julia E Shrosbree, Grahame J Elder, John A Eisman, Jacqueline R Center
BACKGROUND: Osteoporosis is highly prevalent in the heart and lung transplant population. Given high rates of concurrent renal impairment, there is increasing use of denosumab in this population. However, denosumab may be associated hypocalcaemia, particularly in patients with chronic kidney disease (CKD). AIM: This study sought to explore the risk of hypocalcaemia in a heart and lung transplant cohort prescribed denosumab for osteoporosis. METHODS: We performed a retrospective database review of all surviving heart and lung transplant recipients who had received denosumab for osteoporosis between January 2012 and November 2015...
January 24, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29355169/sex-and-gender-disparities-in-the-epidemiology-and-outcomes-of-chronic-kidney-disease
#16
REVIEW
Juan Jesus Carrero, Manfred Hecking, Nicholas C Chesnaye, Kitty J Jager
Improved understanding of sex and gender-specific differences in the aetiology, mechanisms and epidemiology of chronic kidney disease (CKD) could help nephrologists better address the needs of their patients. Population-based studies indicate that CKD epidemiology differs by sex, affecting more women than men, especially with regard to stage G3 CKD. The effects of longer life expectancy on the natural decline of glomerular filtration rate (GFR) with age, as well as potential overdiagnosis of CKD through the inappropriate use of GFR equations, might be in part responsible for the greater prevalence of CKD in women...
March 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29212466/exploring-the-use-of-tablet-computer-based-electronic-data-capture-system-to-assess-patient-reported-measures-among-patients-with-chronic-kidney-disease-a-pilot-study
#17
Dorothy Wong, Shen Cao, Heather Ford, Candice Richardson, Dmitri Belenko, Evan Tang, Luca Ugenti, Eleanor Warsmann, Amanda Sissons, Yalinie Kulandaivelu, Nathaniel Edwards, Marta Novak, Madeline Li, Istvan Mucsi
BACKGROUND: Collecting patient reported outcome measures (PROMs) via computer-based electronic data capture system may improve feasibility and facilitate implementation in clinical care. We report our initial experience about the acceptability of touch-screen tablet computer-based, self-administered questionnaires among patients with chronic kidney disease (CKD), including stage 5 CKD treated with renal replacement therapies (RRT) (either dialysis or transplant). METHODS: We enrolled a convenience sample of patients with stage 4 and 5 CKD (including patients on dialysis or after kidney transplant) in a single-centre, cross-sectional pilot study...
December 6, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29198686/orthotopic-kidney-transplantation-in-an-elderly-patient-with-various-severe-comorbid-conditions-a-case-report
#18
H Sasaki, R Nakazawa, T Iwata, W Usuba, H Yoshie, E Fujimoto, H Metoki, Y Katsuoka, K Aida, H Kudo, K Koitabashi, M Yazawa, Y Shibagaki, Y Marui, T Chikaraishi
In recent years, the frequency of high-risk kidney transplantations has increased. We report a case in which a 72-year-old man with various severe comorbidities (prostate cancer, diabetes mellitus, complete atrioventricular block, coronary artery stenosis, severe stenosis of the popliteal arteries, and severe calcification of the iliac arteries) who received an orthotopic kidney transplantation. To prevent the occurrence of acute limb ischemia due to the steal phenomenon (caused by the kidney graft), we decided that a heterotopic kidney transplantation involving the iliac arteries was not an appropriate option...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29173815/-focusing-on-kidney-transplantation-in-the-elderly
#19
Mathilde Lemoine, Dominique Guerrot, Dominique Bertrand
Due to the increase in life expectancy and the ageing of end-stage renal disease patients, the number of patients older than 65 years receiving a kidney transplant has been continuously growing over the last fifteen years. The benefits of renal transplantation compared to dialysis in terms of survival and quality of life have been shown in selected recipients over 65, or 70 years. However, the age remains the main limiting factor for the access to the waiting list, and the reluctance of the clinicians can be explained by the multiple comorbidities of these candidates, their limited life expectancy or the shortage of grafts...
November 21, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29113470/posttransplant-immune-activation-innocent-bystander-or-insidious-culprit-of-posttransplant-accelerated-atherosclerosis
#20
Didier Ducloux, Jamal Bamoulid, Thomas Crepin, Jean-Michel Rebibou, Cecile Courivaud, Philippe Saas
Cardiovascular disease is a major cause of morbidity, disability, and mortality in kidney transplant patients. Cumulative reports indicate that the excessive risk of cardiovascular events is not entirely explained by the increased prevalence of traditional cardiovascular risk factors. Atherosclerosis is a chronic inflammatory disease, and it has been postulated that posttransplant immune disturbances may explain the gap between the predicted and observed risks of cardiovascular events. Although concordant data suggest that innate immunity contributes to the posttransplant accelerated atherosclerosis, only few arguments plead for a role of adaptive immunity...
September 2017: Cell Transplantation
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