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https://www.readbyqxmd.com/read/29150989/an-evaluation-of-the-sentifit-270-analyser-for-quantitation-of-faecal-haemoglobin-in-the-investigation-of-patients-with-suspected-colorectal-cancer
#1
Josep M Auge, Cristina Rodriguez, Oihana Espanyol, Liseth Rivero, Silvia Sandalinas, Jaume Grau, Wladimiro Jimenez, Antoni Castells
BACKGROUND: An evaluation of SENTiFIT® 270 (Sentinel Diagnostics, Italy; Sysmex, Spain) analyser for the quantitation of faecal haemoglobin (f-Hb) was performed. METHODS: The analytical imprecision, linearity, carry over and f-Hb stability were determined. Evaluation of the diagnostic accuracy was performed on 487 patients. RESULTS: Within-run and between-run imprecision ranged 1.7%-5.1% and 3.8%-6.2%, respectively. Linearity studies revealed a mean recovery of 101...
November 18, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29150915/epidemiology-of-rhdv2-lagovirus-europaeus-gi-2-in-free-living-wild-european-rabbits-in-portugal
#2
C Rouco, J Abrantes, A Serronha, A M Lopes, E Maio, M J Magalhães, E Blanco, J Bárcena, P J Esteves, N Santos, P C Alves, P Monterroso
As the detection of the first outbreak of a novel aetiological agent of rabbit haemorrhagic disease commonly called RHDV2 or RHDVb (Lagovirus europaeus/GI.2, henceforth GI.2) in France in 2010, the virus rapidly spread throughout continental Europe and nearby islands such as Great Britain, Sardinia, Sicily, the Azores and the Canary Islands among others. The outbreaks of this new lagovirus cause important economic losses in rabbitries, and ecological disruptions by affecting the conservation of rabbit-sensitive top predators...
November 17, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29150600/mapping-tenascin-c-interaction-with-toll-like-receptor-4-reveals-a-new-subset-of-endogenous-inflammatory-triggers
#3
Lorena Zuliani-Alvarez, Anna M Marzeda, Claire Deligne, Anja Schwenzer, Fiona E McCann, Brian D Marsden, Anna M Piccinini, Kim S Midwood
Pattern recognition underpins innate immunity; the accurate identification of danger, including infection, injury, or tumor, is key to an appropriately targeted immune response. Pathogen detection is increasingly well defined mechanistically, but the discrimination of endogenous inflammatory triggers remains unclear. Tenascin-C, a matrix protein induced upon tissue damage and expressed by tumors, activates toll-like receptor 4 (TLR4)-mediated sterile inflammation. Here we map three sites within tenascin-C that directly and cooperatively interact with TLR4...
November 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29150579/septicaemic-pasteurellosis-in-unvaccinated-lambs-in-northern-ireland
#4
(no author information available yet)
Northern ireland disease surveillance, july to september 2017Bibersteinia trehalosi causing septicaemic pasteurellosis in lambsAbortion due to Streptococcus pluranimalium in cattleLymphoma in cattleAcute fasciolosis in sheepErysipelas in pigsMarek's disease in chickens.
November 18, 2017: Veterinary Record
https://www.readbyqxmd.com/read/29150545/tumour-diameter-is-not-reliable-for-management-of-non-secreting-pancreatic-neuroendocrine-tumours
#5
Logan Mills, Panagiotis Drymousis, Yogesh Vashist, Christoph Burdelski, Andreas Prachalias, Parthi Srinivasan, Krishna Menon, Corina Cotoi, Saboor Khan, Judith Cave, Thomas Armstrong, Martin O Weickert, Jakob Izbicki, Joerg Schrader, Andreja Frilling, John K Ramage, Raj Srirajaskanthan
Small non-functioning pancreatic NETs (pNETs) ≤2 cm can pose a management dilemma in terms of surveillance or resection. There is evidence to suggest that a surveillance approach can be considered since there are no significant radiological changes observed in lesions during long-term follow-up. However, other studies have suggested loco-regional spread can be present in ≤2 cm pNETs. The aim of this study was to characterise the prevalence of malignant features and identify any useful predictive variables in a surgically resected cohort of pNETs...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29150489/cumulative-burden-of-inflammation-predicts-colorectal-neoplasia-risk-in-ulcerative-colitis-a-large-single-centre-study
#6
Chang-Ho Ryan Choi, Ibrahim Al Bakir, Nik-Sheng John Ding, Gui-Han Lee, Alan Askari, Janindra Warusavitarne, Morgan Moorghen, Adam Humphries, Ana Ignjatovic-Wilson, Siwan Thomas-Gibson, Brian P Saunders, Matthew D Rutter, Trevor A Graham, Ailsa L Hart
OBJECTIVE: Ulcerative colitis (UC) is a dynamic disease with its severity continuously changing over time. We hypothesised that the risk of colorectal neoplasia (CRN) in UC closely follows an actuarial accumulative inflammatory burden, which is inadequately represented by current risk stratification strategies. DESIGN: This was a retrospective single-centre study. Patients with extensive UC who were under colonoscopic surveillance between 2003 and 2012 were studied...
November 17, 2017: Gut
https://www.readbyqxmd.com/read/29150310/zika-virus-in-french-polynesia-2013-14-anatomy-of-a-completed-outbreak
#7
REVIEW
Didier Musso, Hervé Bossin, Henri Pierre Mallet, Marianne Besnard, Julien Broult, Laure Baudouin, José Eduardo Levi, Ester C Sabino, Frederic Ghawche, Marion C Lanteri, David Baud
The Zika virus crisis exemplified the risk associated with emerging pathogens and was a reminder that preparedness for the worst-case scenario, although challenging, is needed. Herein, we review all data reported during the unexpected emergence of Zika virus in French Polynesia in late 2013. We focus on the new findings reported during this outbreak, especially the first description of severe neurological complications in adults and the retrospective description of CNS malformations in neonates, the isolation of Zika virus in semen, the potential for blood-transfusion transmission, mother-to-child transmission, and the development of new diagnostic assays...
November 14, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29150090/graph-based-representation-of-behavior-in-detection-and-prediction-of-daily-living-activities
#8
Piotr Augustyniak, Grażyna Ślusarczyk
Various surveillance systems capture signs of human activities of daily living (ADLs) and store multimodal information as time line behavioral records. In this paper, we present a novel approach to the analysis of a behavioral record used in a surveillance system designed for use in elderly smart homes. The description of a subject's activity is first decomposed into elementary poses - easily detectable by dedicated intelligent sensors - and represented by the share coefficients. Then, the activity is represented in the form of an attributed graph, where nodes correspond to elementary poses...
November 10, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29149940/immune-activation-in-sepsis
#9
REVIEW
Andrew Conway-Morris, Julie Wilson, Manu Shankar-Hari
Sepsis is caused by a dysregulated host response to infection. Immune responses determine the characteristics of sepsis. The body's protection against infection involves danger signal surveillance and recognition from nonself, effector functions in response to sensing danger signals, homeostatic regulation, and generation of immunologic memory. During sepsis, the immune system is activated by pathogen-associated and host-derived molecular patterns. Detecting these molecular patterns generates multisystem responses...
January 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29149339/human-immunodeficiency-virus-infection-increases-the-risk-of-incident-autoimmune-hemolytic-anemia-a-population-based-cohort-study-in-taiwan
#10
Yung-Feng Yen, Yu-Ching Lan, Chun-Teng Huang, I-An Jen, Marcelo Chen, Chun-Yuan Lee, Pei-Hung Chuang, Yun Lee, Donalde E Morisky, Yi-Ming Arthur Chen
Background: Currently, the association between human immunodeficiency virus (HIV) infection and subsequent development of autoimmune hemolytic anemia (AIHA) remains unclear. This nationwide population-based cohort study aimed to determine the association between incident AIHA and HIV infection in Taiwan. Methods: During 2000-2012, we identified people aged ≧15 years living with HIV (PLWH) from the Taiwan Centers for Disease Control HIV Surveillance System. Individuals were considered to be infected with HIV on the basis of positive results of an HIV type 1 Western blot...
November 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29149310/counting-indirect-crisis-related-deaths-in-the-context-of-a-low-resilience-health-system-the-case-of-maternal-and-neonatal-health-during-the-ebola-epidemic-in-sierra-leone
#11
Laura Sochas, Andrew Amos Channon, Sara Nam
Although the number of direct Ebola-related deaths from the 2013 to 2016 West African Ebola outbreak has been quantified, the number of indirect deaths, resulting from decreased utilization of routine health services, remains unknown. Such information is a key ingredient of health system resilience, essential for adequate allocation of resources to both 'crisis response activities' and 'core functions'. Taking stock of indirect deaths may also help the concept of health system resilience achieve political traction over the traditional approach of disease-specific surveillance...
November 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29149259/pancreatic-cancer-incidence-trends-evidence-from-the-surveillance-epidemiology-and-end-results-seer-population-based-data
#12
Vanessa L Gordon-Dseagu, Susan S Devesa, Michael Goggins, Rachael Stolzenberg-Solomon
Background: Annual pancreatic cancer incidence rates have been increasing. We examine pancreatic cancer incidence trends by demographics and histologic type. Methods: Data from the Surveillance, Epidemiology and End Results (SEER) registries were available to assess temporal trends and pancreatic cancer rates from 1974 to 2013. Results: Pancreatic cancer incidence rates declined between the 1970s and 1990s but increased from 1994 to 2013 among White males...
November 14, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29149205/kir-content-genotypes-associate-with-carriage-of-hepatitis-b-surface-antigen-e-antigen-and-hbv-viral-load-in-gambians
#13
Louis-Marie Yindom, Maimuna Mendy, Christopher Bodimeade, Caroline Chambion, Peter Aka, Hilton C Whittle, Sarah L Rowland-Jones, Robert Walton
BACKGROUND: Hepatocellular carcinoma (HCC) causes over 800,000 deaths worldwide annually, mainly in low income countries, and incidence is rising rapidly in the developed world with the spread of hepatitis B (HBV) and C (HCV) viruses. Natural Killer (NK) cells protect against viral infections and tumours by killing abnormal cells recognised by Killer-cell Immunoglobulin-like Receptors (KIR). Thus genes and haplotypes encoding these receptors may be important in determining both outcome of initial hepatitis infection and subsequent chronic liver disease and tumour formation...
2017: PloS One
https://www.readbyqxmd.com/read/29149123/precision-medicine-accelerating-the-science-to-revolutionize-cancer-care%C3%A2
#14
Jeannine M Brant, Deborah K Mayer
BACKGROUND: Precision medicine in cancer care uses specific information about a person's tumor to help diagnose, plan treatment, prognosticate, and surveil throughout the cancer trajectory. Applications exist for cancer prevention, early detection, cancer treatment, and supportive care. Several national initiatives (e.g., National Cancer Moonshot Initiative) support these efforts to accelerate this science forward.
. OBJECTIVES: This article presents an overview of the way in which precision medicine is revolutionizing cancer care...
December 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29148962/design-and-implementation-of-observational-studies-to-measure-disease-burden-with-a-focus-on-stroke
#15
George Howard, Virginia J Howard
Observational epidemiological studies have the dual goals of measuring disease burden and assessing the association between exposures and outcomes. This report focuses on the first of these goals and provides an overview of design considerations of commonly used approaches, specifically community surveillance studies, cross-sectional studies, and longitudinal cohort studies. Each of these designs has strengths and weaknesses, with no study design being superior in all cases. Rather, these designs are complementary to achieve a better understanding of the burden of stroke...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29148911/report-from-enhanced-safety-surveillance-of-two-influenza-vaccines-vaxigrip-and-intanza-15%C3%AE-g-in-two-european-countries-during-influenza-season-2016-17-and-comparison-with-2015-16-season
#16
Anne Laure Chabanon, Hélène Bricout, Céline Ballandras, Audrey Souverain, Timothy David Caroe, Karina M Butler
Passive enhanced safety surveillance (ESS) was implemented in the United Kingdom and in the Republic of Ireland for Vaxigrip and Intanza 15µg influenza vaccines during the 2016/17 influenza season. Lessons learned during 2015/16 ESS implementation were integrated and applied towards the current ESS. The primary objective was to estimate the reporting rates of suspected adverse reactions (ARs) occurring within 7 days of vaccination with Vaxigrip or Intanza 15µg. For Vaxigrip (N = 962), 17 vaccinees (1.8%) reported 59 suspected ARs (6...
November 17, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29148628/clinical-significance-of-st-depression-at-exercise-stress-testing-in-competitive-athletes-usefulness-of-coronary-ct-during-screening
#17
Fabio Sperandii, Emanuele Guerra, Eliana Tranchita, Carlo Minganti, Chiara Lanzillo, Antonia Nigro, Federico Quaranta, Attilio Parisi, Mauro DI Roma, Luciano Maresca, Federica Fagnani, Leonardo Calò
BACKGROUND: Congenital coronary anomalies (CCAs) and coronary artery disease (CAD) arouse intense scientific and clinical interest in sports medicine and sports cardiology medical communities because of their potential to trigger sudden cardiac death (SCD) in athletes. Exercise stress testing represent the first instrumental assessment to evaluate electrocardiographic changes during effort. Coronary computed tomography angiography (CCTA) is an advanced accurate noninvasive imaging modality for excluding CAD and abnormalities of origin and course of coronary vessels...
November 17, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29148375/west-nile-virus-lineage-2-in-horses-and-other-animals-with-neurologic-disease-south-africa-2008-2015
#18
Marietjie Venter, Marthi Pretorius, James A Fuller, Elizabeth Botha, Mpho Rakgotho, Voula Stivaktas, Camilla Weyer, Marco Romito, June Williams
During 2008-2015 in South Africa, we conducted West Nile virus surveillance in 1,407 animals with neurologic disease and identified mostly lineage 2 cases in horses (7.4%, 79/1,069), livestock (1.5%, 2/132), and wildlife (0.5%, 1/206); 35% were fatal. Geographic correlation of horse cases with seropositive veterinarians suggests disease in horses can predict risk in humans.
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29148242/infrapopliteal-peripheral-arterial-disease-and-critical-limb-ischemia-the-time-has-come-for-collaborative-streamlined-diagnostic-and-treatment-paradigms
#19
EDITORIAL
Michael S Levy
The diagnosis, surveillance, and management of infrapopliteal critical limb ischemia remain inconsistent among clinicians. This study demonstrates that using an absolute ankle pressure of >73 mm Hg or an absolute toe pressure increase of 1 mm Hg or greater post endovascular intervention in patients with infrapopliteal critical limb ischemia may be predictive of a reduction in target limb revascularization, amputation, and death. This study highlights the need for vascular societies to come together to promote standardized screening, surveillance, and treatment paradigms for this complex population...
November 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29147641/severity-of-acute-zika-virus-infection-a-prospective-emergency-room-surveillance-study-during-the-2015-2016-outbreak-in-suriname
#20
Pieter Vroon, Jimmy Roosblad, Fauzia Poese, Jan Wilschut, John Codrington, Stephen Vreden, Rens Zonneveld
Acute Zika virus (ZIKV) infection is usually mild and self-limiting. Earlier, we reported three cases of fatal acute ZIKV infection in patients without typical signs of ZIKV, but rather with criteria of systemic inflammation response syndrome (SIRS). To follow up these observations, we prospectively included patients at the emergency room with temperature instability and suspected to have acute ZIKV infection, SIRS, or both. A total of 102 patients were included of whom N = 21 (21%) were suspected of acute ZIKV infection, N = 56 (55%) of acute ZIKV infection with SIRS criteria, and N = 25 (24%) of SIRS alone...
2017: IDCases
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