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https://www.readbyqxmd.com/read/29669535/assessment-of-subjective-emotional-valence-and-long-lasting-impact-of-life-events-development-and-psychometrics-of-the-stralsund-life-event-list-sel
#1
Johanna König, Andrea Block, Mathias Becker, Kristin Fenske, Johannes Hertel, Sandra Van der Auwera, Kathleen Zymara, Henry Völzke, Harald Jürgen Freyberger, Hans Jörgen Grabe
BACKGROUND: Life events (LEs) are associated with future physical and mental health. They are crucial for understanding the pathways to mental disorders as well as the interactions with biological parameters. However, deeper insight is needed into the complex interplay between the type of LE, its subjective evaluation and accompanying factors such as social support. The "Stralsund Life Event List" (SEL) was developed to facilitate this research. METHODS: The SEL is a standardized interview that assesses the time of occurrence and frequency of 81 LEs, their subjective emotional valence, the perceived social support during the LE experience and the impact of past LEs on present life...
April 18, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29658825/alternative-kinship-structures-resilience-and-social-support-among-immigrant-trans-latinas-in-the-usa
#2
Sel J Hwahng, Bennett Allen, Cathy Zadoretzky, Hannah Barber, Courtney McKnight, Don Des Jarlais
Latinas comprise the largest racial/ethnic group of trans women (male-to-female transgender people) in New York City, where HIV seroprevalence among trans Latinas has been found to be as high as 49%. Despite this population's high risk of HIV, little is known about resilience among trans Latinas that may provide protective health factors. Six focus groups and one in-depth interview were conducted with 34 low-income trans/gender-variant people of colour who attended transgender support groups at harm reduction programmes in New York City...
April 16, 2018: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/29656366/sodium-selenite-ameliorates-both-intestinal-and-extra-intestinal-changes-in-acetic-acid-induced-colitis-in-rats
#3
Samar M Soliman, Walaa Wadie, Samia A Shouman, Afaf A Ainshoka
Selenium and its derivatives including sodium selenite (sod sel) belong to the group of essential trace elements needed for proper health and nutrition. They are fairly safe and possess antioxidant and anti-inflammatory properties. The aim of present investigation was to elucidate the effect of sod sel on experimental colitis model in rats. Colitis was induced by intrarectal instillation of 4% (v/v) acetic acid. Two hours later, sod sel was given to rats on a daily basis for 15 consecutive days. Clinical symptoms, colon mass index, spleen weight inflammatory markers, hematological, biochemical, macroscopic, and histological changes were determined...
April 14, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29651097/unraveling-the-compromised-biomechanical-performance-of-type-2-diabetes-and-roux-en-y-gastric-bypass-bone-by-linking-mechanical-structural-and-physico-chemical-properties
#4
Carlos Marin, Georgios Papantonakis, Kathleen Sels, G Harry van Lenthe, Guillaume Falgayrac, Roman Vangoitsenhoven, Bart Van der Schueren, Guillaume Penel, Frank Luyten, Katleen Vandamme, Greet Kerckhofs
Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with obesity and hyperglycemia. Roux-en-Y gastric bypass (RYGB) surgery is a common treatment for severely obese patients and T2DM. Both RYGB and T2DM are linked to increased skeletal fragility, though the exact mechanisms are poorly understood. Our aim was to characterize the structural, mechanical and compositional properties of bones from diet-induced obese and RYGB-treated obese (bypass) mice to elucidate which the exact factors are contributing to the increased skeletal fragility...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29629791/at-what-cost-examining-the-cost-effectiveness-of-a-universal-social-emotional-learning-program
#5
Leah J Hunter, James C DiPerna, Susan Crandall Hart, Max Crowley
Although implementation of universal social-emotional learning programs is becoming more common in schools, few studies have examined the cost-effectiveness of such programs. As such, the purpose of this article is two fold. First, we provide an overview of cost-effectiveness methods for school-based programs, and second, we share results of a cost-effectiveness analysis (CEA) of a universal social-emotional learning (SEL) program, the Social Skills Improvement System-Classwide Intervention Program (SSIS-CIP; Elliott & Gresham, 2007)...
March 2018: School Psychology Quarterly
https://www.readbyqxmd.com/read/29610304/structural-characterization-of-a-non-heme-iron-active-site-in-zeolites-that-hydroxylates-methane
#6
Benjamin E R Snyder, Lars H Böttger, Max L Bols, James J Yan, Hannah M Rhoda, Ariel B Jacobs, Michael Y Hu, Jiyong Zhao, E Ercan Alp, Britt Hedman, Keith O Hodgson, Robert A Schoonheydt, Bert F Sels, Edward I Solomon
Iron-containing zeolites exhibit unprecedented reactivity in the low-temperature hydroxylation of methane to form methanol. Reactivity occurs at a mononuclear ferrous active site, α-Fe(II), that is activated by N2 O to form the reactive intermediate α-O. This has been defined as an Fe(IV)=O species. Using nuclear resonance vibrational spectroscopy coupled to X-ray absorption spectroscopy, we probe the bonding interaction between the iron center, its zeolite lattice-derived ligands, and the reactive oxygen...
April 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29595411/comparison-of-relative-and-absolute-values-of-magnetic-resonance-imaging-in-the-diagnosis-of-spinal-epidural-lipomatosis
#7
Yuxi Ge, Xiaohan Yang, Yaqian You, Yinghua Xuan, Gen Yan
Objective To describe spinal epidural lipomatosis (SEL) of the lumbar region and evaluate the relative versus absolute values of epidural fat (EF) to determine which is more appropriate when using magnetic resonance imaging (MRI). Design Comparative study. Setting Hospital. Participants Eight SEL patients and 40 healthy adults. Interventions MRI measurement of EF. Outcome Measures The MRI-based EF thickness, cutoff value, and coefficient of variation (CV) were calculated. Frequency distribution maps for the absolute EF value and the relative EF/DuS value were created...
March 29, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29589968/radiographic-features-of-lingual-mandibular-bone-depression-using-dental-cone-beam-computed-tomography
#8
Liu Liu, Byung Chul Kang, Suk Ja Yoon, Jae Seo Lee, Sel Ae Hwang
OBJECTIVES: To describe accurately the radiographic characteristics of lingual mandibular bone depression (LMBD) using CBCT images. METHODS: This study included 30 cases of LMBD with CBCT images from 29 patients. Age, sex, location, shape, size, and the relationships of the LMBDs to adjacent anatomical structures such as the mandibular inferior cortex and mandibular canal were recorded. The correlation between age and size was evaluated using Pearson's correlation coefficient...
March 28, 2018: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29565308/total-and-added-sugar-intake-assessment-in-eight-latin-american-countries
#9
Mauro Fisberg, Irina Kovalskys, Georgina Gómez, Attilio Rigotti, Lilia Yadira Cortés Sanabria, Martha Cecilia Yépez García, Rossina Gabriella Pareja Torres, Marianella Herrera-Cuenca, Ioná Zalcman Zimberg, Berthold Koletzko, Michael Pratt, Luis A Moreno Aznar, Viviana Guajardo, Regina Mara Fisberg, Cristiane Hermes Sales, Ágatha Nogueira Previdelli
Non-communicable diseases are growing at an alarming rate in Latin America. We assessed total and added sugar intake in Argentina, Brazil, Chile, Colombia, Costa Rica, Ecuador, Peru, and Venezuela, to verify the adequacy of the World Health Organization's recommendations, considering gender, socioeconomic level (SEL) and age. A total of 9218 non-institutionalized individuals living in urban areas (age range 15-65 years) were assessed in the Latin American Study of Nutrition and Health (ELANS), a multicenter household population-based cross-sectional survey...
March 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29549113/selective-inhibition-of-the-p38%C3%AE-mapk-mk2-axis-inhibits-inflammatory-cues-including-inflammasome-priming-signals
#10
Chun Wang, Susan Hockerman, E Jon Jacobsen, Yael Alippe, Shaun R Selness, Heidi R Hope, Jeffrey L Hirsch, Stephen J Mnich, Matthew J Saabye, William F Hood, Sheri L Bonar, Yousef Abu-Amer, Ariela Haimovich, Hal M Hoffman, Joseph B Monahan, Gabriel Mbalaviele
p38α activation of multiple effectors may underlie the failure of global p38α inhibitors in clinical trials. A unique inhibitor (CDD-450) was developed that selectively blocked p38α activation of the proinflammatory kinase MK2 while sparing p38α activation of PRAK and ATF2. Next, the hypothesis that the p38α-MK2 complex mediates inflammasome priming cues was tested. CDD-450 had no effect on NLRP3 expression, but it decreased IL-1β expression by promoting IL-1β mRNA degradation. Thus, IL-1β is regulated not only transcriptionally by NF-κB and posttranslationally by the inflammasomes but also posttranscriptionally by p38α-MK2...
March 16, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29543324/changes-in-intracranial-volume-and-cranial-shape-in-modern-koreans-over-four-decades
#11
Ye Sel Kim, In Sung Park, Hyun Jung Kim, Dasom Kim, Nam Joon Lee, Im Joo Rhyu
OBJECTIVES: This study investigated whether there was any secular change in cranial vault morphology among Koreans born between the 1930s and 1970s, a period of dramatic shift in Korea's socioeconomic conditions. MATERIALS AND METHODS: Using three-dimensional MRI volumetry, we obtained the intracranial volume (ICV) and craniometric measurements of 115 healthy Koreans: 58 individuals (32 males and 26 females) born in the 1930s (1926-1936) and 57 (28 males and 29 females) born in the 1970s (1972-1979)...
March 15, 2018: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29540208/exosomes-from-patients-with-septic-shock-convey-mirnas-related-to-inflammation-and-cell-cycle-regulation-new-signaling-pathways-in-sepsis
#12
Juliana Monte Real, Ludmila Rodrigues Pinto Ferreira, Gustavo Henrique Esteves, Fernanda Christtanini Koyama, Marcos Vinícius Salles Dias, João Evangelista Bezerra-Neto, Edécio Cunha-Neto, Flavia Ribeiro Machado, Reinaldo Salomão, Luciano Cesar Pontes Azevedo
BACKGROUND: Exosomes isolated from plasma of patients with sepsis may induce vascular apoptosis and myocardial dysfunction by mechanisms related to inflammation and oxidative stress. Despite previous studies demonstrating that these vesicles contain genetic material related to cellular communication, their molecular cargo during sepsis is relatively unknown. In this study, we evaluated the presence of microRNAs (miRNAs) and messenger RNAs (mRNAs) related to inflammatory response and redox metabolism in exosomes of patients with septic shock...
March 15, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29515571/nanoparticles-for-the-induction-of-antigen-specific-immunological-tolerance
#13
REVIEW
Takashi Kei Kishimoto, Roberto A Maldonado
Antigen-specific immune tolerance has been a long-standing goal for immunotherapy for the treatment of autoimmune diseases and allergies and for the prevention of allograft rejection and anti-drug antibodies directed against biologic therapies. Nanoparticles have emerged as powerful tools to initiate and modulate immune responses due to their inherent capacity to target antigen-presenting cells (APCs) and deliver coordinated signals that can elicit an antigen-specific immune response. A wide range of strategies have been described to create tolerogenic nanoparticles (tNPs) that fall into three broad categories...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29500584/preclinical-evaluation-of-avermectins-as-novel-therapeutic-agents-for-alcohol-use-disorders
#14
REVIEW
Sheraz Khoja, Nhat Huynh, Alicia M P Warnecke, Liana Asatryan, Michael W Jakowec, Daryl L Davies
The deleterious effects of alcohol use disorders (AUDs) on human health have been documented worldwide. The enormous socioeconomic burden coupled with lack of efficacious pharmacotherapies underlies the need for improved treatment strategies. At present, there is a growing body of preclinical evidence that demonstrates the potential of avermectins [ivermectin (IVM), selamectin (SEL), abamectin (ABM), and moxidectin (MOX)] in treatment of AUDs. Avermectins are derived by fermentation of soil micro-organism, Streptomyces avermitilis, and have been extensively used for treatment of parasitic infections...
March 2, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29496961/mapk-signaling-couples-scf-mediated-degradation-of-translational-regulators-to-oocyte-meiotic-progression
#15
Edyta Kisielnicka, Ryuji Minasaki, Christian R Eckmann
RNA-binding proteins (RBPs) are important regulators of gene expression programs, especially during gametogenesis. How the abundance of particular RBPs is restricted to defined stages of meiosis remains largely elusive. Here, we report a molecular pathway that subjects two nonrelated but broadly evolutionarily conserved translational regulators (CPB-3/CPEB and GLD-1/STAR) to proteosomal degradation in Caenorhabditis elegans germ cells at the transition from pachytene to diplotene of meiotic prophase. Both RBPs are recognized by the same ubiquitin ligase complex, containing the molecular scaffold Cullin-1 and the tumor suppressor SEL-10/FBXW7 as its substrate recognition subunit...
March 1, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29488686/molecular-identification-of-four-novel-cytochrome-p450-genes-related-to-the-development-of-resistance-of-spodoptera-exigua-lepidoptera-noctuidae-to-chlorantraniliprole
#16
Xuegui Wang, Yiqu Chen, Changwei Gong, Xinge Yao, Chunxian Jiang, Qunfang Yang
BACKGOUND: The beet armyworm, Spodoptera exigua, is an omnivorous insect that damages a variety of crops worldwide. Chlorantraniliprole is a new diamide insecticide that acts on the ryanodine receptors in insects. The aim of this study was to explore the key genes that related to the development of resistant of S. exigua to chlorantraniliprole. RESULTS: Transcriptomes were compared between beet armyworms from a susceptible laboratory strain (Sus-Lab) and Sus-Lab screened with LC25 sublethal doses of chlorantraniliprole for six generations (SE-Sel)...
February 28, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29454698/udder-health-of-dairy-cows-fed-different-dietary-energy-levels-after-a-short-or-no-dry-period-without-use-of-dry-cow-antibiotics
#17
R J van Hoeij, T J G M Lam, R M Bruckmaier, J Dijkstra, G J Remmelink, B Kemp, A T M van Knegsel
Reports on the effects of length of dry period (DP) on udder health of cows that were not treated with dry cow antibiotics are scarce. Additionally, the effects of a reduced dietary energy level for cows with a 0-d DP on udder health have not yet been studied. The aims of this study were (1) to compare effects of a 0-d or 30-d DP without use of dry cow antibiotics on udder health across the DP and subsequent lactation in dairy cows fed different dietary energy levels and (2) to evaluate associations between udder health and metabolic status of dairy cows...
February 14, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29446477/atp-sensitive-k-channel-subunits-kir6-1-kir6-2-are-the-candidate-mediators-regulating-ameliorating-effects-of-pulsed-magnetic-field-on-aortic-contractility-in-diabetic-rats
#18
Isil Ocal, Mehmet B Yilmaz, Sabriye Kocaturk-Sel, Turan Tufan, Mehmet A Erkoc, Gamze Comertpay, Hale Oksuz, Esma D Barc
Diabetes mellitus is a metabolic disease that causes increased morbidity and mortality in developed and developing countries. With recent advancements in technology, alternative treatment methods have begun to be investigated in the world. This study aims to evaluate the effect of pulsed magnetic field (PMF) on vascular complications and contractile activities of aortic rings along with Kir6.1 and Kir6.2 subunit expressions of ATP-sensitive potassium channels (KATP ) in aortas of controlled-diabetic and non-controlled diabetic rats...
February 15, 2018: Bioelectromagnetics
https://www.readbyqxmd.com/read/29406541/on-the-mechanism-of-rapid-metal-exchange-between-thiolate-protected-gold-and-gold-silver-clusters-a-time-resolved-in-situ-xafs-study
#19
Bei Zhang, Olga V Safonova, Stephan Pollitt, Giovanni Salassa, Annelies Sels, Rania Kazan, Yuming Wang, Günther Rupprechter, Noelia Barrabés, Thomas Bürgi
The fast metal exchange reaction between Au38 and AgxAu38-x nanoclusters in solution at -20 °C has been studied by in situ X-ray absorption spectroscopy (time resolved quick XAFS) in transmission mode. A cell was designed for this purpose consisting of a cooling system, remote injection and mixing devices. The capability of the set-up is demonstrated for second and minute time scale measurements of the metal exchange reaction upon mixing Au38/toluene and AgxAu38-x/toluene solutions at both Ag K-edge and Au L3-edge...
February 6, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29403255/unusual-cause-of-lumbar-canal-stenosis-in-8-th-decade-of-life-spinal-epidural-lipomatosis
#20
Manoj Phalak, Sukanta Das, Manmohan Singh, Bhawani Shanker Sharma
Spinal Epidural lipomatosis (SEL) is an uncommon condition, usually presents in young and middle aged patients, with male preponderance. Idiopathic SEL is rare, particularly in 8th decade of life. SEL should also be considered as a differential diagnosis in approach of elderly patient presenting with lumbar canal stenosis. Such a case of 77 year old man is presented here.
October 2017: Journal of Craniovertebral Junction and Spine
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