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https://www.readbyqxmd.com/read/28523359/arginine-cga-codons-as-a-source-of-nonsense-mutations-a-possible-role-in-multivariant-gene-expression-control-of-mrna-quality-and-aging
#1
Georgy A Romanov, Victor S Sukhoverov
Methylation of cytosine residues in DNA of higher eukaryotes, including humans, creates "hot spots" of C→T transitions in the genome. The predominantly methylated sequence in mammalian DNAs is CG (CpG). Among CG-containing codons, CGA codons for arginine are unique due to their ability to create stop codons TGA (UGA in mRNA) upon epigenetic-mediated mutation. As such nonsense mutations can have a strong adverse effect on the cell and organism, we have performed a study, on the example of human genes, aimed to characterise the anticipated effects of epigenetic-mediated nonsense mutations CGA→TGA in somatic cells...
May 18, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28510033/the-antagonistic-effect-of-selenium-on-cadmium-induced-damage-and-mrna-levels-of-selenoprotein-genes-and-inflammatory-factors-in-chicken-kidney-tissue
#2
Xinyue Wang, Rongkun Bao, Jing Fu
Selenium (Se) is a necessary trace mineral in the diet of humans and animals. Cadmium (Cd) is a toxic heavy metal that can damage animal organs, especially the kidneys. Antagonistic interactions between Se and Cd have been reported in previous studies. However, little is known about the effects of Se against Cd toxicity and on the mRNA levels of 25 selenoprotein genes and inflammatory factors in chicken kidneys. In the current study, we fed chickens with a Se-treated, Cd-treated, or Se/Cd treated diet for 90 days...
May 16, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28499585/multipotent-adult-progenitor-cells-improve-the-hematopoietic-function-in-myelodysplasia
#3
Valerie D Roobrouck, Esther Wolfs, Michel Delforge, Dorien Broekaert, Soumen Chakraborty, Kathleen Sels, Thomas Vanwelden, Bryan Holvoet, Larissa Lhoest, Satish Khurana, Shubham Pandey, Chloé Hoornaert, Peter Ponsaerts, Tom Struys, Nancy Boeckx, Peter Vandenberghe, Christophe M Deroose, Catherine M Verfaillie
BACKGROUND AIMS: Myelodysplastic syndromes (MDS) are a group of clonal stem cell disorders affecting the normal hematopoietic differentiation process and leading to abnormal maturation and differentiation of all blood cell lineages. Treatment options are limited, and there is an unmet medical need for effective therapies for patients with severe cytopenias. METHODS: We demonstrate that multipotent adult progenitor cells (MAPC) improve the function of hematopoietic progenitors derived from human MDS bone marrow (BM) by significantly increasing the frequency of primitive progenitors as well as the number of myeloid colonies...
June 2017: Cytotherapy
https://www.readbyqxmd.com/read/28490767/biliverdin-reductase-inhibitors-did-not-improve-severe-unconjugated-hyperbilirubinemia-in-vivo
#4
Remco van Dijk, Sem J Aronson, Dirk R de Waart, Stan F van de Graaf, Suzanne Duijst, Jurgen Seppen, Ronald Oude Elferink, Ulrich Beuers, Piter J Bosma
We aimed to identify potent biliverdin reductase (BVRA) inhibitors as a novel concept for the treatment of severe unconjugated hyperbilirubinemia. 1280 FDA-approved compounds were screened in vitro for their ability to inhibit human and rat BVRA activity and 26 compounds were identified as BVRA inhibitors. Montelukast and Disulfiram were selected as potentially clinically applicable drugs and tested to reduce serum unconjugated bilirubin (UCB) levels in the Ugt1a1-deficient rat, a model for chronic unconjugated hyperbilirubinemia...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28470925/modalities-and-effects-of-left-ventricle-unloading-on-extracorporeal-life-support-a-review-of-the-current-literature
#5
Paolo Meani, Sandro Gelsomino, Eshan Natour, Daniel M Johnson, Hans-Peter Brunner La Rocca, Federico Pappalardo, Elham Bidar, Maged Makhoul, Giuseppe Raffa, Samuel Heuts, Pieter Lozekoot, Suzanne Kats, Niels Sluijpers, Rick Schreurs, Thijs Delnoij, Alice Montalti, Jan Willem Sels, Marcel van de Poll, Paul Roekaerts, Thomas Poels, Eric Korver, Zaheer Babar, Jos Maessen, Roberto Lorusso
INTRODUCTION/AIM: Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) support is increasingly used in refractory cardiogenic shock and cardiac arrest, but is characterized by a rise in afterload of the left ventricle (LV) which may ultimately either further impair or delay cardiac contractility improvement. The aim of this study was to provide a comprehensive overview regarding the different LV venting techniques and results currently available in the literature. METHODS: A systematic literature search was performed in the PubMed database: 207 articles published between 1993 and 2016 were included...
May 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28461472/minimizing-irreversible-losses-in-quantum-systems-by-local-counterdiabatic-driving
#6
Dries Sels, Anatoli Polkovnikov
Counterdiabatic driving protocols have been proposed [Demirplak M, Rice SA (2003) J Chem Phys A 107:9937-9945; Berry M (2009) J Phys A Math Theor 42:365303] as a means to make fast changes in the Hamiltonian without exciting transitions. Such driving in principle allows one to realize arbitrarily fast annealing protocols or implement fast dissipationless driving, circumventing standard adiabatic limitations requiring infinitesimally slow rates. These ideas were tested and used both experimentally and theoretically in small systems, but in larger chaotic systems, it is known that exact counterdiabatic protocols do not exist...
May 1, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28460651/transcatheter-closure-of-the-patent-foramen-ovale-in-children-intermediate-term-follow-up-results
#7
Kutay Sel, Hakan H Aykan, Derya Duman, Ebru Aypar, Süheyla Özkutlu, Dursun Alehan, Tevfik Karagöz
The patent foramen ovale is almost a normal anatomical hole between the atria with ~30% incidence in the general population. It has been suggested that the patent foramen ovale is the cause of some neurological events, which is explained by paradoxical embolism. Transcatheter closure of the patent foramen ovale is a common procedure in adult patients with cerebral ischaemic events, but there are limited data investigating the results in children. Between January, 2005 and February, 2014, 17 patients' patent foramen ovales were closed by the transcatheter approach in our department...
May 2, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28434139/neurological-manifestations-of-atypical-celiac-disease-in-childhood
#8
Çiğdem Genç Sel, Erhan Aksoy, Ayşe Aksoy, Deniz Yüksel, Ferda Özbay
Various typical and atypical neurological manifestations can be seen as the initial symptoms of celiac disease (CD). We suggest that gluten toxicity is the most suspicious triggering risk factor for probable pathophysiological pathways of neurological involvement in atypical CD. The medical charts of 117 patients diagnosed with atypical CD were retrieved from a tertiary center in Ankara, Turkey. Eight patients reported as having neurologic manifestations as initiating symptoms were evaluated in detail. The initial neurological manifestations of CD in our study included atypical absence, which was reported first in this study, generalized tonic-clonic seizures, complex partial seizures, severe axial hypotonia and down phenotype, multifocal leukoencephalopathy, mild optic neuritis, attention deficit hyperactivity disorder, and short duration headaches...
April 22, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28433394/a-modelling-comparison-between-received-sound-levels-produced-by-a-marine-vibroseis-array-and-those-from-an-airgun-array-for-some-typical-seismic-survey-scenarios
#9
Alec J Duncan, Linda S Weilgart, Russell Leaper, Michael Jasny, Sharon Livermore
Marine Vibroseis (MV) may provide a marine seismic sound source that has less environmental impact than conventional airguns. Modelled sound levels from a realistic MV array and airgun array with similar downward energy at frequencies <100Hz were compared under three scenarios: shallow, deep, and slope. Changing the layout of the MV array's higher frequency sources reduced sound exposure levels (SELs) by 4dB. At 100m range this MV was 20dB lower in peak-to-peak sound pressure level vs. the airgun array, decreasing to 12dB lower at 5km, the maximum modelled range for peak levels...
April 19, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28405276/a-simulation-approach-to-assessing-environmental-risk-of-sound-exposure-to-marine-mammals
#10
Carl R Donovan, Catriona M Harris, Lorenzo Milazzo, John Harwood, Laura Marshall, Rob Williams
Intense underwater sounds caused by military sonar, seismic surveys, and pile driving can harm acoustically sensitive marine mammals. Many jurisdictions require such activities to undergo marine mammal impact assessments to guide mitigation. However, the ability to assess impacts in a rigorous, quantitative way is hindered by large knowledge gaps concerning hearing ability, sensitivity, and behavioral responses to noise exposure. We describe a simulation-based framework, called SAFESIMM (Statistical Algorithms For Estimating the Sonar Influence on Marine Megafauna), that can be used to calculate the numbers of agents (animals) likely to be affected by intense underwater sounds...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28397199/proliferation-and-maturation-of-intratumoral-blood-vessels-in-women-with-malignant-ovarian-tumors-assessed-with-cancer-stem-cells-marker-nestin-and-platelet-derived-growth-factor-pdgf-b
#11
Sylwia Czekierdowska, Norbert Stachowicz, Mieczysław Chróściel, Artur Czekierdowski
OBJECTIVES: Platelet-derived growth factor B (PDGF-B) and nestin have been suggested to be useful in the assessment of neoangiogenesis in malignant ovarian masses. We aimed to investigate a possible association of these markers with newly formed microcapillaries and perivascular cells in ovarian tumors. MATERIAL AND METHODS: Microvessel density (MVD) and pericytes were studied in 82 women with ovarian neoplasms, including 7 benign cysts, 7 borderline masses, 64 epithelial ovarian cancers and 4 other malignant ovarian tumors...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28380525/supplementation-of-organic-and-inorganic-selenium-to-late-gestation-and-early-lactation-beef-cows-effect-on-progeny-feedlot-performance-and-carcass-characteristics
#12
C R Muegge, K M Brennan, J P Schoonmaker
Angus × Simmental cows ( = 48, BW = 594 kg, BCS = 5.26, age = 2.7) pregnant with male fetuses were used to determine the effect of selenium source during the last 80 d of gestation and first 108 d of lactation on progeny feedlot performance. At 203 d of gestation, cows were blocked by BW, breed composition, and calf sire and randomly allotted to 1 of 3 treatments: no supplemental Se, 3 mg/d inorganic Se (sodium selenite), and 3 mg/d organic Se (Sel-plex). Maternal diets were formulated to contain 10.4% CP and 0...
March 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28375553/zeolites-as-sustainable-catalysts-for-the-selective-synthesis-of-renewable-bisphenols-from-lignin-derived-monomers
#13
Paola Ferrini, Steven-Friso Koelewijn, Joost Van Aelst, Nicolas Nuttens, Bert F Sels
Alternative biobased bisphenols from lignocellulosic biomass are not only favorable to reduce the environmental impact of current petroleum-derived plastics, but they can be simultaneously beneficial for health issues related to bisphenol A (BPA). Additionally, conventional BPA synthesis entails a large excess of unrecoverable homogeneous acid catalyst (e.g., HCl) or unrecyclable thermolabile sulfonated resins. In this report, zeolites are proposed as recoverable and thermally stable solid acids for the Brønsted-acid-catalyzed condensation between 4-methylguaiacol and formaldehyde to selectively produce renewable bisphenols...
April 4, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28364807/laboratory-selection-of-chlorpyrifos-resistance-in-an-invasive-pest-phenacoccus-solenopsis-homoptera-pseudococcidae-cross-resistance-stability-and-fitness-cost
#14
Masood Ejaz, Muhammad Babar Shahzad Afzal, Ghulam Shabbir, José Eduardo Serrão, Sarfraz Ali Shad, Wali Muhammad
The cotton mealybug, Phenacoccus solenopsis is an important polyphagous sucking pest of ornamentals, horticultural and fiber crops worldwide. Some P. solenopsis populations have developed insecticide resistance. This study evaluated cross-resistance, stability of insecticide resistance and life history traits affected by chlorpyrifos resistance in P. solenopsis. After nine generations selected with chlorpyrifos, P. solenopsis exhibited a 539.76-fold resistance level compared to an unselected population (UNSEL Pop)...
April 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28362113/staphylococcal-enterotoxins-and-enterotoxin-like-toxins-with-special-reference-to-dairy-products-an-overview
#15
Noreddine Benkerroum
Staphylococcal enterotoxins (SEs) have been raising health concerns for food safety due to their association with Staphylococcal Food Poisoning (SFP). As superantigens, they also cause the life threatening Toxic Shock Syndrome (TSS), the transmission of which via food cannot be ruled out despite the lack of epidemiological evidence. To date, at least 23 of these exotoxins are known and separated into SEs and staphylococcal enterotoxin-like (SEl) depending on whether or not they invoke emesis. This work presents an up-to-date overview on the presently known SEs/SEls from the perspective of their classification, pathogenesis, and genetic organisation...
March 31, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28361302/transfer-of-asymmetry-between-proteinogenic-amino-acids-under-harsh-conditions
#16
Arkadii V Tarasevych, Thomas Vives, Valeriy N Snytnikov, Jean-Claude Guillemin
The heating above 400 °C of serine, cysteine, selenocysteine and threonine leads to a complete decomposition of the amino acids and to the formation in low yields of alanine for the three formers and of 2-aminobutyric acid for the latter. At higher temperature, this amino acid is observed only when sublimable α-alkyl-α-amino acids are present, and with an enantiomeric excess dependent on several parameters. Enantiopure or enantioenriched Ser, Cys, Sel or Thr is not able to transmit its enantiomeric excess to the amino acid formed during its decomposition...
March 31, 2017: Origins of Life and Evolution of the Biosphere
https://www.readbyqxmd.com/read/28360782/determination-of-genotypic-and-phenotypic-characteristics-of-friedreich-s-ataxia-and-autosomal-dominant-spinocerebellar-ataxia-types-1-2-3-and-6
#17
Pınar Bengi Boz, Filiz Koç, Sabriye Kocatürk Sel, Ali İrfan Güzel, Halil Kasap
INTRODUCTION: This study aimed to analyze the genotypic characteristics of Friedreich's ataxia (FA) and autosomal dominant ataxias [such as spinocerebellar ataxia (SCA) types 1, 2, 3, and 6] using molecular and biological methods in hereditary cerebellar ataxia considering both clinical and electrophysiological findings. METHODS: The study included 129 indexed cases, who applied to the neurology department and were diagnosed with hereditary cerebellar ataxia through clinical, laboratory, and electrophysiological findings, and 15 sibling patients who were diagnosed through family scanning (144 cases in total); their genetic analyses were also performed...
June 2016: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/28358562/partner-expected-affect-how-you-feel-now-is-predicted-by-how-your-partner-thought-you-felt-before
#18
Laura Sels, Eva Ceulemans, Peter Kuppens
Romantic partners can modulate each other's emotions in many ways, resulting in interwoven emotional lives. Here, building on findings from basic psychological research, we propose a novel way of such interconnectedness, termed partner-expected affect, in which perceptions of a partner's feelings may positively predict how this partner will actually feel at a later moment in time. We evaluated this hypothesis by means of an experience sampling study in which 100 romantic partners (50 couples) reported on the level of valence and arousal of their own feelings and of the perceived feelings of their partners 10 times a day throughout a week...
March 30, 2017: Emotion
https://www.readbyqxmd.com/read/28357136/repeatability-and-agreement-of-central-corneal-thickness-and-keratometry-measurements-between-four-different-devices
#19
Laszlo Kiraly, Jana Stange, Kathleen S Kunert, Saadettin Sel
Background. To estimate repeatability and comparability of central corneal thickness (CCT) and keratometry measurements obtained by four different devices in healthy eyes. Methods. Fifty-five healthy eyes from 55 volunteers were enrolled in this study. CCT (IOLMaster 700, Pentacam HR, and Cirrus HD-OCT) and keratometry readings (IOLMaster 700, Pentacam HR, and iDesign) were measured. For statistical analysis, the corneal spherocylinder was converted into power vectors (J0, J45). Repeatability was assessed by intraclass correlation coefficient (ICC)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28342729/repeatability-and-agreement-of-scheimpflug-based-and-swept-source-optical-biometry-measurements
#20
Saadettin Sel, Jana Stange, Delia Kaiser, Laszlo Kiraly
PURPOSE: To evaluate the repeatability and comparability of biometry parameters between a Scheimpflug-based topography with axial length measurement (Pentacam AXL, Oculus, Wetzlar, Germany) and a swept-source optical biometry (IOLMaster 700, Carl Zeiss Meditec AG, Jena, Germany). METHODS: A total of 50 eyes from 50 adult subjects had biometry measurements in one session three times using the Pentacam AXL and the IOLMaster 700. Keratometry, anterior chamber depth (ACD) and axial length (AL) values were obtained by both devices...
March 22, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
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