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https://www.readbyqxmd.com/read/28634058/apoptotic-gene-expression-profiles-and-dna-damage-levels-in-rat-liver-treated-with-perfluorooctane-sulfonate-and-protective-role-of-curcumin
#1
Dilek Eke, Ayla Çelik, Bertan Yilmaz, Nurcan Aras, Sabriye Kocatürk Sel, Davut Alptekin
Perfluorinated compounds (PFCs) such as PFOS and PFOA, are xenobiotics that can be detected worldwide in the environment and humans. PFOS (C8F17SO3(-)) is a fluorinated organic compound has been used for decades in industrial and commercial products. We investigated the genotoxic and apoptotic impact of PFOS in rat liver using comet assay, micronucleus test and apoptotic gene expression methods for caspase 3, caspase 8 and the protective role of curcumin on the PFOS- induced damage under chronic exposure. In this study, rats were treated either with three different PFOS doses only (0...
June 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28631234/quality-matters-implementation-moderates-student-outcomes-in-the-paths-curriculum
#2
Neil Humphrey, Alexandra Barlow, Ann Lendrum
Analyses of the relationship between levels of implementation and outcomes of school-based social and emotional learning (SEL) interventions are relatively infrequent and are typically narrowly focused. Thus, our objective was to assess the relationship between variability in a range of implementation dimensions and intervention outcomes in the Promoting Alternative Thinking Strategies (PATHS) curriculum. Implementation of PATHS was examined in 69 classrooms across 23 schools in the first year of a major randomized controlled trial...
June 19, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28627920/reliability-and-validity-of-a-spanish-language-assessment-of-children-s-social-emotional-learning-skills
#3
Jaclyn M Russo, Clark McKown, Nicole M Russo-Ponsaran, Adelaide Allen
Few Spanish language tools are available for assessing important social-emotional learning (SEL) skills. The present study presents evidence of the psychometric properties of a Spanish-language version of SELweb (SELweb-S), a web-based system for assessing children's ability to recognize others' emotions and perspectives, solve social problems, and engage in self-control. With a sample of 524 students in Grades K to 3, we examined the reliability and validity of SELweb-S. This study provided evidence that (a) individual assessment modules exhibited moderate to high internal consistency and moderate 6-month temporal stability, (b) composite assessment scores exhibited high reliability, (c) assessment module scores fit a theoretically coherent factor structure, and (d) performance on SELweb-S assessment modules was positively related to teacher-reported SEL skills...
June 19, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28595059/coming-to-the-new-d-a-r-e-a-preliminary-test-of-the-officer-taught-elementary-keepin-it-real-curriculum
#4
L Edward Day, Michelle Miller-Day, Michael L Hecht, Desiree Fehmie
The present study reports a preliminary evaluation of D.A.R.E.'s new elementary school keepin' it REAL substance abuse prevention program. Given the widespread dissemination of D.A.R.E., this evaluation, even though of short term effects, has important implications for national prevention efforts. The new prevention curriculum teaches social and emotional competencies such as decision making and resistance skills. Social and emotional competencies and other risk factors were examined among students (N=943) in 26 classrooms, 13 classrooms in the treatment condition (n=359) and 13 classrooms in the control condition (n=584) using a quasi-experimental matched group design...
May 23, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28582663/molecular-and-epidemiological-characterization-of-staphylococcal-foodborne-outbreak-of-staphylococcus-aureus-harboring-seg-sei-sem-sen-seo-and-selu-genes-without-production-of-classical-enterotoxins
#5
Kaoru Umeda, Hiromi Nakamura, Kaori Yamamoto, Nobuko Nishina, Kiyoshi Yasufuku, Yuki Hirai, Teruo Hirayama, Kaoru Goto, Atsushi Hase, Jun Ogasawara
Staphylococcal food poisoning is the result of consumption of food contaminated with staphylococcal enterotoxins (SEs) produced by Staphylococcus aureus. To date, 23 SEs and SE-like enterotoxins (SEls) have been described in the literature. They are divided into classical SEs (SEA-SEE) and new SE/SEls (SEG-SElX). Some have proved to be foodborne-inducible, but others remain unidentified. In May 2016, at an elderly group home in Osaka city, Japan, an outbreak from foodborne pathogens occurred among lunch party participants...
May 30, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28555401/emerging-multidrug-resistant-bengal-bay-clone-st772-mrsa-v-in-norway-molecular-epidemiology-2004-2014
#6
A Blomfeldt, K W Larssen, A Moghen, C Gabrielsen, P Elstrøm, H V Aamot, S B Jørgensen
A multidrug-resistant, methicillin-resistant Staphylococcus aureus (MRSA) clone, PVL-positive ST772-MRSA-V, named the Bengal Bay clone, is emerging worldwide. In Norway, where MRSA prevalence is low, a sudden increase in ST772-MRSA-V initiated a nationwide molecular epidemiological study. Clinical data were obtained from the Norwegian Surveillance System for Communicable Diseases (MSIS). S. aureus isolates were characterised by antibiotic susceptibility profiles and comprehensive genotyping (spa typing, MLVA, DNA microarray)...
May 29, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28540450/high-neuronatin-nnat-expression-is-associated-with-poor-outcome-in-breast-cancer
#7
Norbert Nass, Sarah Walter, Dörthe Jechorek, Christine Weissenborn, Atanas Ignatov, Johannes Haybaeck, Saadettin Sel, Thomas Kalinski
Neuronatin (NNAT) is a proteolipid involved in cation homeostasis especially in the developing brain. Its expression has been associated with the progression of lung cancer, glioblastoma, and neuroblastoma as well as glucose induced apoptosis in pancreatic cells. We performed a retrospective study of 148 breast cancer specimens for NNAT expression by immunohistochemistry to evaluate this protein as a prognostic marker for breast cancer. We found a high NNAT immunoreactivity score (by multivariate cox regression) to be an independent prognostic marker for relapse-free (hazard ratio HR = 3...
May 24, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28523359/arginine-cga-codons-as-a-source-of-nonsense-mutations-a-possible-role-in-multivariant-gene-expression-control-of-mrna-quality-and-aging
#8
Georgy A Romanov, Victor S Sukhoverov
Methylation of cytosine residues in DNA of higher eukaryotes, including humans, creates "hot spots" of C→T transitions in the genome. The predominantly methylated sequence in mammalian DNAs is CG (CpG). Among CG-containing codons, CGA codons for arginine are unique due to their ability to create stop codons TGA (UGA in mRNA) upon epigenetic-mediated mutation. As such nonsense mutations can have a strong adverse effect on the cell and organism, we have performed a study, on the example of human genes, aimed to characterise the anticipated effects of epigenetic-mediated nonsense mutations CGA→TGA in somatic cells...
May 18, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28510033/the-antagonistic-effect-of-selenium-on-cadmium-induced-damage-and-mrna-levels-of-selenoprotein-genes-and-inflammatory-factors-in-chicken-kidney-tissue
#9
Xinyue Wang, Rongkun Bao, Jing Fu
Selenium (Se) is a necessary trace mineral in the diet of humans and animals. Cadmium (Cd) is a toxic heavy metal that can damage animal organs, especially the kidneys. Antagonistic interactions between Se and Cd have been reported in previous studies. However, little is known about the effects of Se against Cd toxicity and on the mRNA levels of 25 selenoprotein genes and inflammatory factors in chicken kidneys. In the current study, we fed chickens with a Se-treated, Cd-treated, or Se/Cd treated diet for 90 days...
May 16, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28499585/multipotent-adult-progenitor-cells-improve-the-hematopoietic-function-in-myelodysplasia
#10
Valerie D Roobrouck, Esther Wolfs, Michel Delforge, Dorien Broekaert, Soumen Chakraborty, Kathleen Sels, Thomas Vanwelden, Bryan Holvoet, Larissa Lhoest, Satish Khurana, Shubham Pandey, Chloé Hoornaert, Peter Ponsaerts, Tom Struys, Nancy Boeckx, Peter Vandenberghe, Christophe M Deroose, Catherine M Verfaillie
BACKGROUND AIMS: Myelodysplastic syndromes (MDS) are a group of clonal stem cell disorders affecting the normal hematopoietic differentiation process and leading to abnormal maturation and differentiation of all blood cell lineages. Treatment options are limited, and there is an unmet medical need for effective therapies for patients with severe cytopenias. METHODS: We demonstrate that multipotent adult progenitor cells (MAPC) improve the function of hematopoietic progenitors derived from human MDS bone marrow (BM) by significantly increasing the frequency of primitive progenitors as well as the number of myeloid colonies...
June 2017: Cytotherapy
https://www.readbyqxmd.com/read/28490767/biliverdin-reductase-inhibitors-did-not-improve-severe-unconjugated-hyperbilirubinemia-in-vivo
#11
Remco van Dijk, Sem J Aronson, Dirk R de Waart, Stan F van de Graaf, Suzanne Duijst, Jurgen Seppen, Ronald Oude Elferink, Ulrich Beuers, Piter J Bosma
We aimed to identify potent biliverdin reductase (BVRA) inhibitors as a novel concept for the treatment of severe unconjugated hyperbilirubinemia. 1280 FDA-approved compounds were screened in vitro for their ability to inhibit human and rat BVRA activity and 26 compounds were identified as BVRA inhibitors. Montelukast and Disulfiram were selected as potentially clinically applicable drugs and tested to reduce serum unconjugated bilirubin (UCB) levels in the Ugt1a1-deficient rat, a model for chronic unconjugated hyperbilirubinemia...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28470925/modalities-and-effects-of-left-ventricle-unloading-on-extracorporeal-life-support-a-review-of-the-current-literature
#12
Paolo Meani, Sandro Gelsomino, Eshan Natour, Daniel M Johnson, Hans-Peter Brunner La Rocca, Federico Pappalardo, Elham Bidar, Maged Makhoul, Giuseppe Raffa, Samuel Heuts, Pieter Lozekoot, Suzanne Kats, Niels Sluijpers, Rick Schreurs, Thijs Delnoij, Alice Montalti, Jan Willem Sels, Marcel van de Poll, Paul Roekaerts, Thomas Poels, Eric Korver, Zaheer Babar, Jos Maessen, Roberto Lorusso
INTRODUCTION/AIM: Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) support is increasingly used in refractory cardiogenic shock and cardiac arrest, but is characterized by a rise in afterload of the left ventricle (LV) which may ultimately either further impair or delay cardiac contractility improvement. The aim of this study was to provide a comprehensive overview regarding the different LV venting techniques and results currently available in the literature. METHODS: A systematic literature search was performed in the PubMed database: 207 articles published between 1993 and 2016 were included...
May 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28461472/minimizing-irreversible-losses-in-quantum-systems-by-local-counterdiabatic-driving
#13
Dries Sels, Anatoli Polkovnikov
Counterdiabatic driving protocols have been proposed [Demirplak M, Rice SA (2003) J Chem Phys A 107:9937-9945; Berry M (2009) J Phys A Math Theor 42:365303] as a means to make fast changes in the Hamiltonian without exciting transitions. Such driving in principle allows one to realize arbitrarily fast annealing protocols or implement fast dissipationless driving, circumventing standard adiabatic limitations requiring infinitesimally slow rates. These ideas were tested and used both experimentally and theoretically in small systems, but in larger chaotic systems, it is known that exact counterdiabatic protocols do not exist...
May 16, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28460651/transcatheter-closure-of-the-patent-foramen-ovale-in-children-intermediate-term-follow-up-results
#14
Kutay Sel, Hakan H Aykan, Derya Duman, Ebru Aypar, Süheyla Özkutlu, Dursun Alehan, Tevfik Karagöz
The patent foramen ovale is almost a normal anatomical hole between the atria with ~30% incidence in the general population. It has been suggested that the patent foramen ovale is the cause of some neurological events, which is explained by paradoxical embolism. Transcatheter closure of the patent foramen ovale is a common procedure in adult patients with cerebral ischaemic events, but there are limited data investigating the results in children. Between January, 2005 and February, 2014, 17 patients' patent foramen ovales were closed by the transcatheter approach in our department...
May 2, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28434139/neurological-manifestations-of-atypical-celiac-disease-in-childhood
#15
Çiğdem Genç Sel, Erhan Aksoy, Ayşe Aksoy, Deniz Yüksel, Ferda Özbay
Various typical and atypical neurological manifestations can be seen as the initial symptoms of celiac disease (CD). We suggest that gluten toxicity is the most suspicious triggering risk factor for probable pathophysiological pathways of neurological involvement in atypical CD. The medical charts of 117 patients diagnosed with atypical CD were retrieved from a tertiary center in Ankara, Turkey. Eight patients reported as having neurologic manifestations as initiating symptoms were evaluated in detail. The initial neurological manifestations of CD in our study included atypical absence, which was reported first in this study, generalized tonic-clonic seizures, complex partial seizures, severe axial hypotonia and down phenotype, multifocal leukoencephalopathy, mild optic neuritis, attention deficit hyperactivity disorder, and short duration headaches...
April 22, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28433394/a-modelling-comparison-between-received-sound-levels-produced-by-a-marine-vibroseis-array-and-those-from-an-airgun-array-for-some-typical-seismic-survey-scenarios
#16
Alec J Duncan, Linda S Weilgart, Russell Leaper, Michael Jasny, Sharon Livermore
Marine Vibroseis (MV) may provide a marine seismic sound source that has less environmental impact than conventional airguns. Modelled sound levels from a realistic MV array and airgun array with similar downward energy at frequencies <100Hz were compared under three scenarios: shallow, deep, and slope. Changing the layout of the MV array's higher frequency sources reduced sound exposure levels (SELs) by 4dB. At 100m range this MV was 20dB lower in peak-to-peak sound pressure level vs. the airgun array, decreasing to 12dB lower at 5km, the maximum modelled range for peak levels...
April 19, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28405276/a-simulation-approach-to-assessing-environmental-risk-of-sound-exposure-to-marine-mammals
#17
Carl R Donovan, Catriona M Harris, Lorenzo Milazzo, John Harwood, Laura Marshall, Rob Williams
Intense underwater sounds caused by military sonar, seismic surveys, and pile driving can harm acoustically sensitive marine mammals. Many jurisdictions require such activities to undergo marine mammal impact assessments to guide mitigation. However, the ability to assess impacts in a rigorous, quantitative way is hindered by large knowledge gaps concerning hearing ability, sensitivity, and behavioral responses to noise exposure. We describe a simulation-based framework, called SAFESIMM (Statistical Algorithms For Estimating the Sonar Influence on Marine Megafauna), that can be used to calculate the numbers of agents (animals) likely to be affected by intense underwater sounds...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28397199/proliferation-and-maturation-of-intratumoral-blood-vessels-in-women-with-malignant-ovarian-tumors-assessed-with-cancer-stem-cells-marker-nestin-and-platelet-derived-growth-factor-pdgf-b
#18
Sylwia Czekierdowska, Norbert Stachowicz, Mieczysław Chróściel, Artur Czekierdowski
OBJECTIVES: Platelet-derived growth factor B (PDGF-B) and nestin have been suggested to be useful in the assessment of neoangiogenesis in malignant ovarian masses. We aimed to investigate a possible association of these markers with newly formed microcapillaries and perivascular cells in ovarian tumors. MATERIAL AND METHODS: Microvessel density (MVD) and pericytes were studied in 82 women with ovarian neoplasms, including 7 benign cysts, 7 borderline masses, 64 epithelial ovarian cancers and 4 other malignant ovarian tumors...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28380525/supplementation-of-organic-and-inorganic-selenium-to-late-gestation-and-early-lactation-beef-cows-effect-on-progeny-feedlot-performance-and-carcass-characteristics
#19
C R Muegge, K M Brennan, J P Schoonmaker
Angus × Simmental cows ( = 48, BW = 594 kg, BCS = 5.26, age = 2.7) pregnant with male fetuses were used to determine the effect of selenium source during the last 80 d of gestation and first 108 d of lactation on progeny feedlot performance. At 203 d of gestation, cows were blocked by BW, breed composition, and calf sire and randomly allotted to 1 of 3 treatments: no supplemental Se, 3 mg/d inorganic Se (sodium selenite), and 3 mg/d organic Se (Sel-plex). Maternal diets were formulated to contain 10.4% CP and 0...
March 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28375553/zeolites-as-sustainable-catalysts-for-the-selective-synthesis-of-renewable-bisphenols-from-lignin-derived-monomers
#20
Paola Ferrini, Steven-Friso Koelewijn, Joost Van Aelst, Nicolas Nuttens, Bert F Sels
Alternative biobased bisphenols from lignocellulosic biomass are not only favorable to reduce the environmental impact of current petroleum-derived plastics, but they can be simultaneously beneficial for health issues related to bisphenol A (BPA). Additionally, conventional BPA synthesis entails a large excess of unrecoverable homogeneous acid catalyst (e.g., HCl) or unrecyclable thermolabile sulfonated resins. In this report, zeolites are proposed as recoverable and thermally stable solid acids for the Brønsted-acid-catalyzed condensation between 4-methylguaiacol and formaldehyde to selectively produce renewable bisphenols...
May 22, 2017: ChemSusChem
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