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https://www.readbyqxmd.com/read/29222897/platelet-related-cytokines-among-normal-body-mass-index-overweight-and-obese-malaysians
#1
Nasrin Riyahi, Eusni Rahayu Mohd Tohit, Subashini C Thambiah, Zuriati Ibrahim
BACKGROUND AND OBJECTIVES: Recent studies have reported that obesity is associated with platelet activation and systemic inflammation. Malaysia has the highest prevalence of obesity, hence, this research is performed to evaluate the development of low-grade inflammation and platelet activation, measured using soluble CD40 ligand (sCD40L) and soluble P-selectin (sP-sel), and to determine their association with obesity. In addition, we assessed the mean platelet volume (MPV) and platelet count (PLT), which are novel parameters consistently associated with obesity...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29221916/dna-methylation-signatures-at-endoplasmic-reticulum-stress-genes-are-associated-with-adiposity-and-insulin-resistance
#2
Omar Ramos-Lopez, Jose I Riezu-Boj, Fermin I Milagro, J Alfredo Martinez
A sustained activation of the unfolded protein response and the subsequent endoplasmic reticulum (ER) stress has been involved in the onset and severity of several metabolic diseases. The aim of this study was to analyze the association of DNA methylation signatures at ER stress genes with adiposity traits and related metabolic disorders. An epigenomic analysis within the Methyl Epigenome Network Association (MENA) project was conducted in an adult population (n=474). DNA methylation status in peripheral white blood cells was analyzed by a microarray approach...
November 28, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29203971/incidence-of-spinal-epidural-lipomatosis-in-patients-with-spinal-stenosis
#3
Jason Bradley Malone, Patrick Jon Bevan, Todd Jay Lewis, Andrew David Nelson, Doug Edward Blaty, Michael Eastland Kahan
Inroduction: Spinal Epidural Lipomatosis (SEL) is believed to be a rare disorder. The incidence and prevalence of clinically symptomatic SEL in patients with spinal stenosis has never been reported in the literature. Our study aims to determine the prevalence, incidence, and associated risk factors of SEL in patients with the diagnosis of spinal stenosis. Methods: This is a retrospective study. We reviewed the charts of 831 patients with the diagnosis of spinal stenosis over a 30 month period...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29203885/monocyte-gene-expression-in-childhood-obesity-is-associated-with-obesity-and-complexity-of-atherosclerosis-in-adults
#4
G C Keustermans, D Kofink, A Eikendal, W de Jager, J Meerding, R Nuboer, J Waltenberger, A O Kraaijeveld, J W Jukema, J W Sels, J Garssen, B J Prakken, F W Asselbergs, E Kalkhoven, I E Hoefer, G Pasterkamp, H S Schipper
Childhood obesity coincides with increased numbers of circulating classical CD14++CD16- and intermediate CD14++CD16+ monocytes. Monocytes are key players in the development and exacerbation of atherosclerosis, which prompts the question as to whether the monocytosis in childhood obesity contributes to atherogenesis over the years. Here, we dissected the monocyte gene expression profile in childhood obesity using an Illumina microarray platform on sorted monocytes of 35 obese children and 16 lean controls. Obese children displayed a distinctive monocyte gene expression profile compared to lean controls...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167650/social-and-emotional-learning-and-academic-achievement-in-portuguese-schools-a-bibliometric-study
#5
REVIEW
Ana M Cristóvão, Adelinda A Candeias, José Verdasca
Social and Emotional Learning (SEL) is an educational movement that is gaining ground throughout the world. We can define SEL as the capacity to recognize and manage emotions, solve problems effectively, and establish positive relationships with others. Research has demonstrated the significant role of SEL in promoting healthy student development and academic achievement. Extensive research confirms that SEL competencies: can be taught, that they promote positive development and reduce problem behaviors, and that they improve students' academic achievement and citizenship...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29166559/dynamic-nature-of-thiolate-monolayer-in-au25-sr-18-nanoclusters
#6
Giovanni Salassa, Annelies Sels, Fabrizio Mancin, Thomas Burgi
Thiolate monolayer, protecting gold nanocluster, is the principal responsible of their chemical behavior and their interaction with the environment. Understanding the parameters that influence the sta-bility and reactivity of the monolayer will enable its precise and controlled functionalization. Here we present a protocol for the investigation of the monolayer reactivity in Au25(SR)18 based on MALDI mass spectrometry and NMR spectroscopy. Thiol ex-change reaction between cluster and thiol molecules has been inves-tigated showing how this reaction is affected by the thiol affinity for Au25...
November 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/29144506/soluble-p-selectin-promotes-retinal-ganglion-cell-survival-through-activation-of-nrf2-signaling-after-ischemia-injury
#7
Kishan Kapupara, Yao-Tseng Wen, Rong-Kung Tsai, Shun-Ping Huang
Retinal ischemic injuries play an important role in the pathogenesis of several eye disorders. Inflammation and oxidative stress are key players in ischemic injuries. Following retinal ischemia, vascular endothelial cells and leukocytes express several inflammatory adhesion receptors, such as selectins and cell adhesion molecules. P-selectin stimulates leukocyte recruitment to platelet aggregates and has an important role in vascular homeostasis and inflammatory leukocyte extravasation. Soluble P-selectin can be neuroprotective through competitive binding to the receptors of endogenous P-selectin molecules...
November 16, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29125768/self-assembling-elastin-like-hydrogels-for-timolol-delivery-development-of-an-ophthalmic-formulation-against-glaucoma
#8
Alicia Fernández-Colino, Daniela A Quinteros, Daniel A Allemandi, Alessandra Girotti, Santiago D Palma, F Javier Arias
This work focuses on improving the effectiveness of current therapies against glaucoma by incorporating self-assembled polymers into the ophthalmic formulation. To that end, we first studied the influence of the dispersing medium on the mechanical performance of self-assembling elastin-like (EL) and silk-elastin-like (SEL) hydrogels by conducting rheological tests. These polymers were subsequently incorporated into the antiglaucoma formulation, which contains timolol maleate (TM) as active ingredient, and in vivo tests, namely adhesion tests and intraocular pressure measurements (IOP), were performed in New Zealand rabbits...
November 21, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29105631/phytoformulation-of-sassurea-lappa-plant-extract-a-single-blind-noninvasive-and-split-face-study-of-cream-on-various-skin-parameters
#9
Qazi Adnan, Naveed Akhtar, Barkat Ali Khan
Saussurea lappa (SL) has been reported for its antioxidant and anti-ageing properties. Due to this reason it can be incorporated in a stable phytoformulations for cosmetic use. The objective of the study was to evaluate the anti-aging potential of cosmetic o/w emulsion containing the botanical extract of SL. An emulsion (o/w) was prepared using TEGO® Care 450 (Polyglceryl-3-Methyl Glucose Distearate) emulsifier and final emulsion was loaded with 4 % extract of SL in aqueous phase. This emulsion evaluated for its antioxidant and anti-ageing properties on healthy human subjects using a non-invasive technique called surface evaluation of living skin (SELS)...
September 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29105091/links-between-contexts-and-middle-to-late-childhood-social-emotional-development
#10
Jeffrey Duong, Catherine P Bradshaw
Guided by the social-emotional learning (SEL) framework, we studied developmental trajectory patterns of five key competency outcomes spanning middle through late childhood: altruism, empathy, self-efficacy, aggression, and hyperactivity. We then assessed their links to middle childhood home, parental, and community contexts. Data from the Institute of Education Sciences' Social and Character Development Program, which comprised nearly 2,400 elementary school students who were followed from Grades 3 through 5, were analyzed using growth mixture modeling...
November 3, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/29084288/closely-related-methicillin-resistant-staphylococcus-aureus-isolates-from-retail-meat-cows-with-mastitis-and-humans-in-japan
#11
Tomomi Sato, Masaru Usui, Noriko Konishi, Akemi Kai, Hidehito Matsui, Hideaki Hanaki, Yutaka Tamura
Methicillin-resistant Staphylococcus aureus (MRSA) is a pervasive healthcare-acquired (HA) pathogen with recent emergence as a community-acquired (CA) pathogen. To elucidate whether meat mediates MRSA transmission between animals and humans in Japan, this study examined MRSA isolates from retail meat (n = 8), cows with mastitis (n = 7), and humans (HA-MRSA = 46 and CA-MRSA = 54) by molecular typing, virulence gene analyses, and antimicrobial susceptibility testing. MRSA isolates from retail meat were classified into sequence type (ST) 8/spa type t1767 (n = 4), ST8/t4133 (n = 1), ST59/t3385 (n = 1), ST88/t375 (n = 1), and ST509/t375 (n = 1)...
2017: PloS One
https://www.readbyqxmd.com/read/29071784/simultaneous-determination-of-niacin-and-pyridoxine-at-trace-levels-by-using-diode-array-high-performance-liquid-chromatography-and-liquid-chromatography-with-quadrupole-time-of-flight-tandem-mass-spectrometry
#12
Sabriye Sel, Elif Öztürk Er, Sezgin Bakırdere
A highly sensitive and simple diode-array high-performance liquid chromatography and liquid chromatography with quadrupole time-of-flight tandem mass spectrometry method was developed for the simultaneous determination of niacin and pyridoxine in pharmaceutical drugs, tap water and wastewater samples. To determine the in vivo behavior of niacin and pyridoxine, analytes were subjected to simulated gastric conditions. The calibration plots of the diode-array high-performance liquid chromatography and liquid chromatography with quadrupole time-of-flight tandem mass spectrometry method showed good linearity over a wide concentration range with close to 1...
October 26, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29063190/-sudden-loss-of-vision-after-cosmetic-face-treatment
#13
F N Auerbach, R Khoramnia, G U Auffarth, J A Carmona Hernandez, T Tandogan, D Kaiser, S Hähnel, S Sel
No abstract text is available yet for this article.
October 23, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29045535/select-2-a-phase-ii-double-blind-randomised-placebo-controlled-study-to-assess-the-efficacy-of-selumetinib-plus-docetaxel-as-a-second-line-treatment-for-patients-with-advanced-or-metastatic-non-small-cell-lung-cancer
#14
J C Soria, A Fülöp, C Maciel, J R Fischer, G Girotto, S Lago, E Smit, G Ostoros, W E E Eberhardt, P Lishkovska, S Lovick, G Mariani, A McKeown, E Kilgour, P Smith, K Bowen, A Kohlmann, D J Carlile, P A Jänne
Background: Combination of selumetinib plus docetaxel provided clinical benefit in a previous Phase II trial for patients with KRAS-mutant advanced non-small cell lung cancer (NSCLC). The Phase II SELECT-2 trial investigated safety and efficacy of selumetinib plus docetaxel for patients with advanced or metastatic NSCLC. Patients and methods: Patients who had disease progression after first-line anti-cancer therapy were randomised (2:2:1) to selumetinib 75 mg BID plus docetaxel 60 mg/m2 or 75 mg/m2 (SEL+DOC 60; SEL+DOC 75), or placebo plus docetaxel 75 mg/m2 (PBO+DOC 75)...
October 3, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045473/identification-of-functionally-important-micrornas-from-rice-inflorescence-at-heading-stage-of-a-qdty4-1-qtl-bearing-near-isogenic-line-under-drought-conditions
#15
Boon Huat Cheah, Sudhir Jadhao, Madavan Vasudevan, Ratnam Wickneswari, Kalaivani Nadarajah
A cross between IR64 (high-yielding but drought-susceptible) and Aday Sel (drought-tolerant) rice cultivars yielded a stable line with enhanced grain yield under drought screening field trials at International Rice Research Institute. The major effect qDTY4.1 drought tolerance and yield QTL was detected in the IR77298-14-1-2-10 Backcrossed Inbred Line (BIL) and its IR87705-7-15-B Near Isogenic Line (NIL) with 93.9% genetic similarity to IR64. Although rice yield is extremely susceptible to water stress at reproductive stage, currently, there is only one report on the detection of drought-responsive microRNAs in inflorescence tissue of a Japonica rice line...
2017: PloS One
https://www.readbyqxmd.com/read/28957736/gene-expression-of-selenoproteins-can-be-regulated-by-thioredoxin-txn-silence-in-chicken-cardiomyocytes
#16
Jie Yang, Sattar Hamid, Qi Liu, Jingzeng Cai, Shiwen Xu, Ziwei Zhang
Thioredoxin (Txn) system is the most crucial antioxidant defense mechanism in myocardium. The aim of this study was to clarify the effect of Txn low expression on 25 selenoproteins in chicken cardiomyocytes. We developed a Se-deficient model (0.033mg/kg) and Txn knock down cardiomyocytes model (siRNA) studies. Western Blot, Quantitative Real-time PCR (qPCR) were performed, and correlation analysis, heat map were used for further analysis. Both low expression of Txn models are significantly decreased (P<0...
September 4, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28951709/fabrication-of-tamarindus-indica-seeds-extract-loaded-cream-for-photo-aged-skin-visioscan-%C3%A2-studies
#17
Muhammad Khurram Waqas, Barkat Ali Khan, Naveed Akhtar, Farzana Chowdhry, Haroon Khan, Sattar Bakhsh, Shahzeb Khan, Akhtar Rasul
INTRODUCTION: Intracellular and extracellular oxidative stress triggered by free radicals promotes skin aging, which is designated by atypical pigmentation and wrinkles. The consumption of antioxidants is an efficacious measure to avert symptoms involved in skin aging. AIM: The current research was commenced to explore the anti-aging potential of antioxidants present in Tamarindus indica seeds extract. MATERIAL AND METHODS: Tamarindus indica seeds extract was obtained by concentrating the ethanolic extract of seeds...
August 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28940925/evaporation-directed-crack-patterning-of-metal-organic-framework-colloidal-films-and-their-application-as-photonic-sensors
#18
Olivier Dalstein, Effrosyni Gkaniatsou, Clemence Sicard, Ozlem Sel, Hubert Perrot, Christian Serre, Cédric Boissière, Marco Faustini
A straightforward crack-patterning method is reported allowing the direct formation of periodic cracks in metal-organic framework (MOF) nanoparticle films during dip-coating deposition. The crack propagation and periodicity can be easily tailored by controlling the evaporation front and the withdrawal speed. Several MOF-patterned films can be fabricated on large surfaces and on several substrates (flat, curved or flexible) including the inner surface of a tube, not achievable by other lithographic techniques...
September 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28922735/assessing-the-interplay-of-childhood-adversities-with-more-recent-stressful-life-events-and-conditions-in-predicting-panic-pathology-among-adults-from-the-general-population
#19
E Asselmann, J Stender, H J Grabe, J König, C O Schmidt, A O Hamm, C A Pané-Farré
BACKGROUND: Although research suggests that (a) childhood adversities and more recent stressful life events/conditions are risk factors for panic pathology and that (b) early life stress increases vulnerability to later psychopathology, it remains unclear whether childhood adversities amplify the association between more recent stressful life events/conditions and panic pathology. METHODS: Data were derived from a general population sample (Study of Health in Pomerania, SHIP)...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28901441/profiling-of-differentially-expressed-genes-in-adipose-tissues-of-multiple-symmetric-lipomatosis
#20
Ke Chen, Linghao Wang, Wenjun Yang, Changfa Wang, Gui Hu, Zhaohui Mo
Multiple symmetric lipomatosis (MSL) is a rare disorder characterized by aberrant multiple and symmetric subcutaneous adipose tissue accumulation in the face, neck, shoulders, back, chest and abdomen, severely affecting the quality of life of patients. At present, precise MSL etiology and pathogenesis remain to be elucidated. The present study first utilized a digital gene expression technique with a next‑generation sequencing platform to profile differentially expressed genes in three cases of MSL vs. normal control tissue...
November 2017: Molecular Medicine Reports
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