PBIS

BACKGROUND: Pediatric penetrating brain injuries (PBIs) are rare but critical traumatic events, often involving foreign objects. This report will emphasize the clinical presentation, diagnosis, and treatment strategies for pediatric PBI cases. CASE DESCRIPTION: This report presents a case of a 7-year-old male patient with a PBI resulting from a nail that penetrated the left mastoid region following a fall from a tree. On admission, the patient maintained consciousness, displayed stable vital signs, and showed no neurological deficits...

Facile construction of a fully biodegradable spherical nucleic acid (SNA) nanoplatform is highly desirable for clinical translations but remains rarely explored. We developed herein the first polycarbonate-based biodegradable SNA nanoplatform for self-codelivery of a chemotherapeutic drug, doxorubicin (DOX), and a human liver-specific miR122 for synergistic chemo-gene therapy of hepatocellular carcinoma (HCC). Ring-opening polymerization (ROP) of a carbonate monomer leads to a well-defined polycarbonate backbone for subsequent DOX conjugation to the pendant side chains via acidic pH-cleavage Schiff base links and miR122 incorporation to the chain termini via click coupling, affording an amphiphilic polycarbonate-DOX-miR122 conjugate, PBis-Mpa30 -DOX-miR122 that can self-assemble into stabilized SNA...

INTRODUCTION: Student health services are associated with improved health outcomes and academic success, particularly among under-resourced college populations. This study compared student health services at Historically Black Colleges and Universities (HBCUs) and Predominantly Black Institutions (PBIs) and identified factors associated with the availability of comprehensive health services (CHS). METHODS: We conducted a secondary analysis of 2022 data from the Integrated Postsecondary Education Data System (IPEDS), the Minority Serving Institutions (MSIs) Directory, and the websites of HBCUs and PBIs ( n =167)...

Polybenzimidazoles (PBIs) are recognized for their remarkable thermal stability due to their unique molecular structure, which is characterized by aromaticity and rigidity. Despite their remarkable thermal attributes, their tensile properties limit their application. To improve the mechanical performance of PBIs, we made a vital modification to their molecular backbone to improve their structural flexibility. Non- π -conjugated components were introduced into PBIs by grafting meta-polyamide (MA) and para-polyamide (PA) onto PBI backbones to form the copolymers PBI- co -MA and PBI- co -PA...

Obstructive jaundice is a clinical syndrome that is commonly seen in gastroenterology. Endoscopic retrograde cholangiopancreatography (ERCP) has been recognized as a first-choice therapeutic approach, with percutaneous biliary interventions (PBIs) being a viable alternative. Recent data questions the performance and safety profile of PBIs.

In this study, we delve into the regioselectivity of nucleophilic reactions involving brominated perylene bisimides (PBIs) and various bidentate aryloxide anions, previously associated with an SRN 1 mechanism. We present herein a new perspective, suggesting that a single-electron-transfer aromatic nucleophilic substitution (SeT-SN Ar) mechanism is a more plausible scenario. Our study reveals the favorable impact of photostimulation on reaction yields, making our method a convenient approach for accessing O- arylated PBIs...

Storage proteins are essential for seed germination and seedling growth, as they provide an indispensable nitrogen source and energy. Our previous report highlighted the defective endosperm development in the serine hydroxymethyltransferase 4 ( OsSHMT4 ) gene mutant, floury endosperm20 - 1 ( flo20-1 ). However, the alterations in storage protein content and distribution within the flo20-1 endosperm remained unclear. Here, the immunocytochemistry analyses revealed a deficiency in storage protein accumulation in flo20-1 ...

Single-photon emissions from individual emitters are crucial in fundamental science and quantum information technologies. Multichromophoric systems, comprising multiple dyes, can exhibit single-photon emissions through efficient annihilation between the excited states; however, exploring this phenomenon in complex systems remains a challenge. In this study, we investigated the photon statistics of emissions from multiple perylene bisimide (PBI) dyes adsorbed onto the surface of CdSe/ZnS quantum dots (QDs). When multiple PBIs were simultaneously excited by both direct excitation and energy transfer from the QD, multiphoton emissions from the PBIs were observed...

As the public health framework has been implemented in schools through multi-tiered systems of support, as in Positive Behavioral Interventions and Supports (PBIS), a prominent interpretation has been that 80% of students will benefit from universal or Tier 1 schoolwide behavior support, around 15% will require added selective or Tier 2 targeted support, and 5% will require the more intensive selective or Tier 3 intervention. The PBIS framework also emphasizes the use of tiered logic, with strengthened efforts at the universal and selective levels when student behavioral or mental health needs exceed expected levels...

PURPOSE: Examine brief parent interventions (PBIs) on a nationally representative sample of teenagers (ages 15-18 years) to change drinking, teens declining (i.e., saying no) to ride with impaired drivers, and increase parent communication about alcohol. METHODS: Parent-teen dyads (N = 1,176) recruited from a web panel completed online surveys at baseline (T1), 30 days (T2), 6 months (T3), and 12 months (T4) post baseline (Psex : 54% female; Tsex : 49% female; Tage : M = 16...

Light-driven changes in supramolecular interactions in perylene bisimides (PBIs) with pendant sulfur-containing functional groups at the bay position are demonstrated. In the ground state, a noncovalent S···X interaction between the σ-hole on sulfur and a heteroatom, X (X = O, N, S), of a neighboring molecule is the main driving force for intermolecular interactions, while in the excited state it is the π-π interaction between PBI scaffolds which drives assembly. The presence of heteroatoms in the solvent results in acceleration of the π-stacking process via the formation of a PBI-solvent complex...

Combat penetrating brain injury (PBI) differs significantly from PBI in civilian environments. Differences include technical factors such as the weapons involved, strained resource environments, and limited medical materials and human resources available. Ethical issues regarding the management of PBI in military settings may occur. This case study examines the case of a 20-year-old member of the French Armed Forces that suffered a penetrating brain injury in a combat situation. The four-quadrant method along with the four principles of medical ethics (respect for autonomy, beneficence, nonmaleficence, and justice) was used to analyze this case and to apply ethics to the practice of military medicine...

Surgical techniques for non-missile penetrating brain injuries (PBI) are challenging because they require good preoperative planning. Generally, extraction is performed ipsilaterally at the entry site. In certain cases, the extraction can be performed contralaterally through the inner end of the foreign body; however, this requires special consideration. We present a case report of a patient who had a stab wound on the head via a screwdriver and underwent surgery, during which extraction was performed contralaterally through the inner end of the screwdriver without inducing any neurological deficit...

BACKGROUND/PURPOSE: Prophylactic antibiotics administration before percutaneous biliary intervention (PBI) is currently recommended, but the underlying evidence is mostly extrapolated from prophylactic antibiotics before surgery. The aim of this study was to evaluate the impact of prophylactic antibiotics administration timing on the incidence of suspected systemic infection after PBI. METHODS: The incidence of suspected systemic infection after PBI was compared in patients who received prophylactic antibiotics at four different time intervals between antibiotics administration and skin puncture for PBI...

In this Perspective, mainly based on the model of structural water molecules (SWs) as bright color emitters, we briefly summarize the development and theoretical elaboration of P-band intermediate state (PBIS) theory as well as its application in several typical catalytic redox reactions. In addition, with a simple equation (2∫ψ2 σ1' + ∫ψ2 σ2 + ∫ψ2 π = 1), we clearly define how the interface states correlate with the three basic parameters of heterogeneous catalysis (conversion, selectivity, and stability), and what is the dynamic nature of catalytic active sites...

Self-assembly versus complexation with polycyclic aromatic hydrocarbon (PAH) guest molecules is studied for a series of perylene bisimides (PBIs). Bulky imide substituents at the PBI guide their self-assembly into dimer aggregates with null-type exciton coupling. Host-guest titration experiments with perylene and triphenylene PAHs afford 1 : 1 and 1 : 2 complexes whose properties are studied by single crystal X-ray analysis and UV/Vis and fluorescence spectroscopy.

BACKGROUND: Teacher-delivered behavioral classroom management interventions are effective for students with or at-risk for attention-deficit/hyperactivity disorder (ADHD) or other disruptive behavior challenges, but they can be difficult for teachers to use in the classroom. In this study, we will pilot test a package of implementation strategies to support teachers in using behavioral classroom interventions for students with ADHD symptoms. METHODS: We will use a 2-group, randomized controlled trial to compare outcomes for teachers who receive Positive Behavior Management Implementation Resources (PBMIR), a theory and data-driven implementation resource package designed to increase teacher implementation of behavioral classroom management interventions, with those who do not receive this additional implementation support...

BACKGROUND: Positive Behavioral Interventions and Supports (PBIS) is a framework for implementing evidence-based interventions for preventing behavioral issues and improving climate in schools. The implementation of school-wide PBIS with fidelity is complex, requiring leadership commitment, teaming, and coordination of systems for tracking behaviors and consequences. Putting these components in place while ensuring alignment with the values and needs of the school community can be difficult for schools with fewer resources, such as rural schools...

A practical protocol for the construction of hydroxylated 2-(1-phenyl-1 H -benzo[ d ]imidazol-2-yl)phenols (PBIs) from N -phenyl- o -phenylenediamine with benzaldehydes was developed. The cascade reaction was enabled by heating a mixture of the two substrates in the presence of air as an oxidant and anhydrous Cu(OAc)2 as a catalyst in dimethyl sulfoxide, and a diverse series of PBIs were synthesized in moderate to good yields (69-81%). Furthermore, the synthesis of the PBIs was enabled via a one-pot cascade reaction that proceeded through subsequent dehydration condensation, intramolecular cyclization, and aromatic C-H hydroxylation...

PURPOSE: It is unclear why parents avoid discussing alcohol use with their emerging adult (EA) children. Understanding parents' reasons for not communicating could inform parent-based interventions (PBIs) aimed at encouraging constructive discussions. The current study adds to the literature by examining common reasons parents avoid discussing alcohol use with their EA children. METHODS: Parents of EAs completed a web-based survey that included items assessing reasons for not communicating about alcohol, as well as measures of alcohol communication intentions, parenting self-efficacy, relationship quality, and interest in participating in an alcohol PBI...