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Preeclampsia proteinuria

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https://www.readbyqxmd.com/read/27882748/-application-of-the-concetrations-ratio-of-soluble-receptor-tyrosine-kinase-type-1-and-placental-growth-factor-for-short-term-prediction-and-diagnosis-of-preeclampsia
#1
Š Bubeníková, A Cíchová, L Roubalová, V Durdová, R Vlk
OBJECTIVE: Bring a comprehensive overview of the available information about applications of the concetration ratio of soluble receptor tyrosine kinase type 1 (sFlt-1), and placental growth factor for short-term prediction and diagnosis of preeclampsia. DESIGN: Overview study. SETTINGS: Department of Midwifery, Faculty of Health Sciences, Olomouc; Department of Clinical Biochemistry, University Hospital Olomouc; Department of Obstetrics and Gynecology, University Hospital Olomouc; Department of Obstetrics and Gynecology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27879452/umbilical-cord-blood-circulating-progenitor-cells-and-endothelial-colony-forming-cells-are-decreased-in-preeclampsia
#2
Diane L Gumina, Claudine P Black, Vivek Balasubramaniam, Virginia D Winn, Christopher D Baker
Preeclampsia (PE) is a pregnancy-specific disease characterized by the new onset of hypertension and proteinuria. Mothers with PE are known to develop endothelial dysfunction, but its effect on infants has been understudied, as newborns are often asymptomatic. Recent studies indicate that infants born from preeclamptic pregnancies develop endothelial dysfunction including higher blood pressure during childhood and an increased risk of stroke later in life. We hypothesize that PE reduces the number and function of fetal angiogenic progenitor cells and may contribute to this increased risk...
November 21, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27874074/second-trimester-urine-nephrin-creatinine-ratio-versus-soluble-fms-like-tyrosine-kinase-1-placental-growth-factor-ratio-for-prediction-of-preeclampsia-among-asymptomatic-women
#3
Tianyue Zhai, Itsuko Furuta, Kinuko Nakagawa, Takashi Kojima, Takeshi Umazume, Satoshi Ishikawa, Takahiro Yamada, Mamoru Morikawa, Hisanori Minakami
This prospective observational study compare urine nephrin:creatinine ratio (NCR, ng/mg) with serum soluble fms-like tyrosine kinase-1:placental growth factor ratio (FPR, pg/pg) for preeclampsia (PE) prediction among unselected asymptomatic pregnant women in 2(nd) trimester. NCR and FPR were determined in 254 paired urine/blood samples collected simultaneously from 254 women at median gestational week (GW) 24 (range, 22-27) without hypertension or significant proteinuria in pregnancy (SPIP). Fifteen (5.9%) developed SPIP and hypertension at GW 34...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27873232/evidence-based-revised-view-of-the-pathophysiology-of-preeclampsia
#4
Asif Ahmed, Homira Rezai, Sophie Broadway-Stringer
Preeclampsia is a life-threatening vascular disorder of pregnancy due to a failing stressed placenta. Millions of women risk death to give birth each year and globally each year, almost 300,000 lose their life in this process and over 500,000 babies die as a consequence of preeclampsia. Despite decades of research, we lack pharmacological agents to treat it. Maternal endothelial oxidative stress is a central phenomenon responsible for the preeclampsia phenotype of high maternal blood pressure and proteinuria...
November 22, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27866414/chemerin-level-in-pregnancies-complicated-by-preeclampsia-and-its-relation-with-disease-severity-and-neonatal-outcomes
#5
Orkun Cetin, Zehra Kurdoglu, Mertihan Kurdoglu, H Guler Sahin
The aims of this prospective study were to detect maternal serum chemerin level in patients with preeclampsia and investigate its association with disease severity and neonatal outcomes. Maternal serum chemerin levels were significantly elevated in severe preeclamptic women (394.72 ± 100.01 ng/ml) compared to mild preeclamptic women (322.11 ± 37.60 ng/ml) and healthy pregnant women (199.96 ± 28.05 ng/ml) (p = .001). Maternal serum chemerin levels were positively correlated with systolic and diastolic blood pressure, C-reactive protein levels, homeostasis model assessment of insulin resistance, proteinuria, AST, ALT, and duration of hospitalisation...
November 21, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27834501/use-of-serum-and-urinary-soluble-sflt-1-and-plgf-in-the-diagnosis-of-preeclampsia
#6
Ping Tang, Jing Xu, Bao-Jun Xie, Qi-Mei Wang
OBJECTIVE: Preeclampsia (PE) is a disorder of pregnancy marked by hypertension and proteinuria with no known treatment aside from pregnancy termination. The pathogenesis of PE is poorly understood, but is thought to originate in the placenta. We assessed the value of measuring serum and urinary soluble deformylase-like tyrosine kinase receptor 1 (sFlt-1), a known target of placental factors, and placental growth factor (PLGF), a key placental signaling molecule, in the diagnosis of PE...
November 11, 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27829661/pathophysiology-of-preeclampsia-an-angiogenic-imbalance-and-long-lasting-systemic-vascular-dysfunction
#7
Takuji Tomimatsu, Kazuya Mimura, Masayuki Endo, Keiichi Kumasawa, Tadashi Kimura
Preeclampsia is a systemic vascular disorder characterized by new-onset hypertension and proteinuria after 20 weeks of gestation. This condition targets several organs, including the kidneys, liver and brain, and is the leading cause of maternal and perinatal morbidity and mortality. Furthermore, recent evidence has revealed preeclampsia as a significant risk factor for future cardiovascular diseases in these women. Over the past decade, increasing evidence has indicated that maternal angiogenic imbalances caused by placental antiangiogenic factors play a central role in the systemic vascular dysfunction underling preeclampsia...
November 10, 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/27818017/low-maternal-25-hydroxyvitamin-d-concentration-increases-the-risk-of-severe-and-mild-preeclampsia
#8
Katharyn M Baca, Hyagriv N Simhan, Robert W Platt, Lisa M Bodnar
PURPOSE: The objective of this case-cohort study was to evaluate the relationship between maternal 25-hydroxyvitamin D (25(OH)D) concentration and preeclampsia overall and by severity. METHODS: From an eligible cohort of 12,861 women who had serum banked from aneuploidy screening in Pittsburgh, Pennsylvania from 1999 to 2010, we randomly sampled a subcohort of 2327 pregnancies and all remaining preeclampsia cases (n = 650 cases). Preeclampsia (defined as new-onset hypertension and proteinuria) and its mild and severe forms were identified using ICD-9 codes...
December 2016: Annals of Epidemiology
https://www.readbyqxmd.com/read/27817102/curcumin-inhibits-placental-inflammation-to-ameliorate-lps-induced-adverse-pregnancy-outcomes-in-mice-via-upregulation-of-phosphorylated-akt
#9
Jianjun Zhou, Huishuang Miao, Xiujun Li, Yali Hu, Haixiang Sun, Yayi Hou
INTRODUCTION: Excessive inflammation results in adverse pregnancy outcomes, including embryonic resorption, fetal growth restriction, and preeclampsia. This study investigated whether curcumin, a highly safe anti-inflammation drug, had protective effect on lipopolysaccharide (LPS)-treated pregnant mice. METHOD: A mouse model of LPS-induced adverse pregnancy outcomes was generated by daily administering LPS from GD 13.5 to GD 16.5. Curcumin was given from GD 0.5...
November 5, 2016: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/27802351/an-integrative-analysis-of-preeclampsia-based-on-the-construction-of-an-extended-composite-network-featuring-protein-protein-physical-interactions-and-transcriptional-relationships
#10
Daniel Vaiman, Francisco Miralles
Preeclampsia (PE) is a pregnancy disorder defined by hypertension and proteinuria. This disease remains a major cause of maternal and fetal morbidity and mortality. Defective placentation is generally described as being at the root of the disease. The characterization of the transcriptome signature of the preeclamptic placenta has allowed to identify differentially expressed genes (DEGs). However, we still lack a detailed knowledge on how these DEGs impact the function of the placenta. The tools of network biology offer a methodology to explore complex diseases at a systems level...
2016: PloS One
https://www.readbyqxmd.com/read/27799724/placental-growth-factor-soluble-fms-like-tyrosine-kinase-1-soluble-endoglin-il-6-and-il-16-as-biomarkers-in-preeclampsia
#11
Carmen Rădulescu, Anca Bacârea, Adina Huțanu, Rozalia Gabor, Minodora Dobreanu
Preeclampsia (PE), an important cause of maternal and perinatal morbidity and mortality worldwide, is a pregnancy-related disease characterized by hypertension and proteinuria after 20 weeks of gestation. The aim of our study was to find a practical panel of biomarkers useful in early diagnosis of PE. This study was carried out at the Obstetrics and Gynecology Department in Tîrgu Mureș University Hospital, Romania, between January 2014 and July 2015 and included 68 pregnant women (47 preeclamptic women and 21 controls) with gestational age between 16 and 20 weeks at enrollment...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27789293/molecular-hydrogen-ameliorates-several-characteristics-of-preeclampsia-in-the-reduced-uterine-perfusion-pressure-rupp-rat-model
#12
Takafumi Ushida, Tomomi Kotani, Hiroyuki Tsuda, Kenji Imai, Tomoko Nakano, Shima Hirako, Yumiko Ito, Hua Li, Yukio Mano, Jingwen Wang, Rika Miki, Eiko Yamamoto, Akira Iwase, Yasuko K Bando, Masaaki Hirayama, Kinji Ohno, Shinya Toyokuni, Fumitaka Kikkawa
Oxidative stress plays an important role in the pathogenesis of preeclampsia. Recently, molecular hydrogen (H2) has been shown to have therapeutic potential in various oxidative stress-related diseases. The aim of this study is to investigate the effect of H2 on preeclampsia. We used the reduced utero-placental perfusion pressure (RUPP) rat model, which has been widely used as a model of preeclampsia. H2 water (HW) was administered orally ad libitum in RUPP rats from gestational day (GD) 12 to 19, starting 2 days before RUPP procedure...
October 24, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27781205/a-unique-cause-of-proteinuria-in-pregnancy-class-ii-lupus-nephritis-with-concomitant-minimal-change-disease
#13
Ryan Kunjal, Rabie Adam-Eldien, Raafat Makary, Francois Jo-Hoy, Charles W Heilig
We report the case of a 22-year-old African American female who presented to another facility for routine follow-up in the 34th week of pregnancy with lower extremity swelling and nephrotic-range proteinuria. Although she was normotensive, it was initially thought that she had preeclampsia. She was monitored carefully and delivery was induced at 37 weeks of gestation. She was transferred to our hospital, where she was diagnosed with systemic lupus erythematosus (SLE) based on clinical and laboratory criteria...
September 2016: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/27755385/the-antihypertensive-mthfr-gene-polymorphism-rs17367504-g-is-a-possible-novel-protective-locus-for-preeclampsia
#14
Liv Cecilie V Thomsen, Nina S McCarthy, Phillip E Melton, Gemma Cadby, Rigmor Austgulen, Ottar K Nygård, Matthew P Johnson, Shaun Brennecke, Eric K Moses, Line Bjørge, Ann-Charlotte Iversen
OBJECTIVE: Preeclampsia is a complex heterogeneous disease commonly defined by new-onset hypertension and proteinuria in pregnancy. Women experiencing preeclampsia have increased risk for cardiovascular diseases (CVD) later in life. Preeclampsia and CVD share risk factors and pathophysiologic mechanisms, including dysregulated inflammation and raised blood pressure. Despite commonalities, little is known about the contribution of shared genes (pleiotropy) to these diseases. This study aimed to investigate whether genetic risk factors for hypertension or inflammation are pleiotropic by also being associated with preeclampsia...
January 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/27754103/os-21-08-novel-reduced-uterine-perfusion-pressure-rupp-model-of-preeclampsia-in-mice
#15
Tomofumi Fushima, Akiyo Sekimoto, Takahiro Minato, Takuya Ito, Yuji Oe, Kiyomi Kisu, Emiko Sato, Kenichi Funamoto, Yoshitaka Kimura, Sadayoshi Ito, Hiroshi Sato, Nobuyuki Takahashi
OBJECTIVE: Preeclampsia (PE) is a pregnancy-induced hypertension with proteinuria that typically develops after 20 weeks of gestation. A reduction in uterine blood flow causes placental ischemia and placental release of anti-angiogenic factors such as soluble fms-like tyrosine kinase (sFlt-1) followed by PE. Although the reduced uterine perfusion pressure (RUPP) model is widely used in rats, investigating the genetics of PE has been problematic because it has been difficult to make a useful RUPP model in mice...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754100/os-21-05-pivotal-role-of-heme-oxygenase-in-amelioration-by-nicotinamide-of-fetal-growth-restriction-associated-with-preeclampsia
#16
Hironobu Nakada, Tomofumi Fushima, Akiyo Sekimoto, Yuji Oe, Emiko Sato, Sadayoshi Ito, Hiroshi Sato, Nobuyuki Takahashi
OBJECTIVE: Preeclampsia (PE) is pregnancy-induced hypertension with proteinuria. It causes maternal death or fetal growth restriction (FGR). Although high BP can be managed with antihypertensive drugs, there is no effective treatment of FGR associated with PE. We have clarified that nicotinamide (Nam) alleviates PE-like condition and FGR induced by soluble fms-like tyrosine kinase-1 (sFlt-1) in mice. But the mechanism of how Nam works is unclear. Because Nam induces cytoprotective heme oxygenase 1 (HO-1), our aim is to clarify whether HO-1 contributes to therapeutic effect of Nam against FGR associated with PE...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753956/os-08-06-metabolomic-analysis-of-a-mouse-model-of-preeclampsia-induced-by-overproducing-sflt-1
#17
Emiko Sato, Yukako Tsunokuni, Tomofumi Fushima, Manami Kaneko, Ritsumi Saito, Akiyo Sekimoto, Daisuke Saigusa, Sadayoshi Ito, Hiroshi Sato, Nobuyuki Takahashi
OBJECTIVE: Preeclampsia (PE) is pregnancy-induced hypertension with proteinuria, and is often associated with fetal growth restriction (FGR). PE is a leading cause of maternal morbidity and mortality. Although alterations in circulating angiogenic factors are pathogenic, the details of pathological mechanisms of PE remain to be elucidated. We investigated changes in metabolites in a mouse model of PE induced by overproducing soluble fms-like tyrosine kinase 1 (sFlt-1) to elucidate the pathological conditions of PE by metabolomics analysis...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753932/os-05-07-role-of-soluble-endoglin-in-the-physiopathology-of-preeclampsia
#18
Jose Lopez-Novoa, Lucia Perez-Roque, Elena Nuñez-Gomez, Claudia Ollauri, Laura Ruiz-Remolina, Miguel Arevalo, Carmelo Bernabeu, Alicia Rodriguez-Barbero, Miguel Pericacho
OBJECTIVE: Preeclampsia, characterized by hypertension and proteinuria occurring after the twentieth week of pregnancy, is a major contributor to maternal and perinatal morbidity and mortality in developed countries. The mechanisms mediating the pathogenesis preeclampsia are far from clear. Strong experimental evidence suggests that placental ischemia, resulting from the inappropriate remodeling of the maternal spiral arteries, stimulates the release of soluble factors causing hypertension and renal damage...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27733023/impact-of-random-urine-proteinuria-on-maternal-and-fetal-outcomes-of-pregnancy-a-retrospective-case-control-study
#19
Eun Hui Bae, Jong Woon Kim, Hong Sang Choi, Seong Kwon Ma, Soo Wan Kim
Background/Aims: Proteinuria is associated with hypertension and preeclampsia in pregnancy. However, the impact of random urine proteinuria on fetal and maternal outcomes has not been established. We investigated the influence of random urine proteinuria on the clinical outcomes of pregnancy. Methods: From January 2008 to December 2010, 2,822 patients were retrospectively studied. A total of 536 pregnant women with proteinuria in random urine and matched controls without proteinuria via propensity score matching were analyzed...
October 13, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27703570/two-pregnancies-with-a-different-outcome-in-a-patient-with-alport-syndrome
#20
Biljana Gerasimovska Kitanovska, Vesna Gerasimovska, Vesna Livrinova
BACKGROUND: Alport syndrome is a genetic disease that progresses to chronic kidney failure, with X-linked, autosomal dominant or autosomal recessive type of inheritance. Women are generally carriers of the mutation and have a milder form of the disease. During pregnancy, they have an increased risk of impaired kidney function and preeclampsia. CASE PRESENTATION: A 27-year old woman, gravida 1, para 0, in her 23rd gestational week came to the outpatient unit of the University Clinic of Nephrology for the first time because of slowly progressing proteinuria and Alport syndrome...
September 15, 2016: Open Access Macedonian Journal of Medical Sciences
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