keyword
MENU ▼
Read by QxMD icon Read
search

Preeclampsia proteinuria

keyword
https://www.readbyqxmd.com/read/29035901/ce-preeclampsia-current-approaches-to-nursing-management
#1
Cindy M Anderson, Mandy J Schmella
A clinical review of risk factors, diagnostic criteria, and patient care. ABSTRACT: Preeclampsia, one of four hypertensive disorders of pregnancy, has traditionally been characterized as new-onset hypertension and proteinuria developing after 20 weeks' gestation. It is, however, now understood to be a complex, progressive, multisystem disorder with a highly variable presentation and a number of potentially life-threatening complications. The American College of Obstetricians and Gynecologists Task Force on Hypertension in Pregnancy has refined preeclampsia diagnostic criteria accordingly, and as the disorder's pathogenesis has been more clearly defined, new targets for screening, diagnosis, prevention, and treatment have emerged...
October 13, 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/29022890/elevated-microrna-34a-contributes-to-trophoblast-cell-apoptosis-in-preeclampsia-by-targeting-bcl-2
#2
M Guo, X Zhao, X Yuan, P Li
Preeclampsia (PE) is one of the most common pregnancy-specific pathologic complications, and is characterised by onset of hypertension and proteinuria. Placental trophoblast cell apoptosis is generally accepted as a major cause of PE. However, the details of the mechanism underlying the condition remain unclear. Here, we aimed to investigate a possible association between microRNA (miR)-34a and human trophoblast cell apoptosis during PE. We evaluated miR-34a expression in placentas from patients with PE compared with those from healthy pregnant individuals...
October 12, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28994563/an-update-on-the-genetics-of-pre-eclampsia
#3
Andee Agius, Roberta Sultana, Christian Camenzuli, Jean Calleja-Agius, Rena Balzan
Pre-eclampsia is a progressive multisystem disorder that is exclusive to human pregnancy and defined as new hypertension presenting after 20 weeks with significant proteinuria. It is a multifactorial condition with a strong genetic component and several genes have been linked with this disorder. The main players implicated in the pathogenesis of preeclampsia include immune maladaptation, haemodynamics, endothelial function, thrombophilic disorders, oxidative stress and lipid metabolism. All of these mechanisms encompass genetic factors that might be responsible for the pathogenic changes taking place...
October 9, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28992178/tadalafil-improves-l-ng-nitroarginine-methyl-ester-induced-preeclampsia-with-fetal-growth-restriction-like-symptoms-in-pregnant-mice
#4
Kento Yoshikawa, Takashi Umekawa, Shintaro Maki, Michiko Kubo, Masafumi Nii, Kayo Tanaka, Hiroaki Tanaka, Kazuhiro Osato, Yuki Kamimoto, Eiji Kondo, Kenji Ikemura, Masahiro Okuda, Kan Katayama, Takekazu Miyoshi, Hiroshi Hosoda, Ning Ma, Toshimichi Yoshida, Tomoaki Ikeda
BACKGROUND: We investigated the efficacy and mechanisms of tadalafil, a selective phosphodiesterase 5 inhibitor, in treating preeclampsia (PE) with fetal growth restriction (FGR) using L-NG-nitroarginine methyl ester (L-NAME)-induced PE with FGR in pregnant mice as our experimental model. METHODS: C57BL/6 mice were divided into 2 groups 11 days postcoitum (d.p.c.). A control group of dams (C dam) received 0.5% carboxymethylcellulose (CMC). A L-NAME-treated group received 1 mg/ml L-NAME dissolved in CMC...
August 3, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28981319/vitamin-d-supplementation-prevents-placental-ischemia-induced-endothelial-dysfunction-by-downregulating-placental-soluble-fms-like-tyrosine-kinase-1
#5
Su-Ling Ma, Xiao-Yu Tian, Ya-Qi Wang, Hui-Feng Zhang, Lei Zhang
Maternal vitamin D deficiency in pregnancy has been associated with an increased risk of preeclampsia. Vascular endothelial dysfunction is a major phenotype of pregnancies with preeclampsia, contributing to increased maternal hypertension and proteinuria. We sought to determine whether vitamin D supplementation would alleviate preeclampsia associated endothelial dysfunction and explore the underlying mechanism using the reduced uterine perfusion pressure (RUPP) rat model. RUPP operated rats were supplemented with 1,25(OH)2D (RUPP+VD) on day 1, 7, and 14 of pregnancy by subcutaneous injection...
October 5, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28979748/the-impact-of-silymarin-on-improvement-of-hepatic-abnormalities-in-patients-with-severe-preeclampsia-a-randomized-clinical-trial
#6
Fahimeh Kaveh Baghbahadorani, Sepideh Miraj
BACKGROUND: Preeclampsia is a pregnancy-specific disorder, associated with increased blood pressure and proteinuria, and in extreme cases it can also cause liver and kidney problems. OBJECTIVE: To determine the impact of silymarin on the improvement of severe preeclampsia. METHODS: This randomized clinical trial was conducted at Hajar Hospital in Shahrekord, Iran, from April 2014 to September 2015. Sixty patients whose pregnancy had ended as a result of severe preeclampsia, were entered into the study...
August 2017: Electronic Physician
https://www.readbyqxmd.com/read/28971026/intensive-care-unit-issues-in-eclampsia-and-hellp-syndrome
#7
REVIEW
Melissa Teresa Chu Lam, Elizabeth Dierking
Preeclampsia, eclampsia and HELLP syndrome are life-threatening hypertensive conditions and common causes of ICU admission among obstetric patients The diagnostic criteria of preeclampsia include: 1) systolic blood pressure (SBP) ≥140 mmHg or diastolic blood pressure (DBP) ≥90 mmHg on two occasions at least 4 hours apart and 2) proteinuria ≥300 mg/day in a woman with a gestational age of >20 weeks with previously normal blood pressures. Eclampsia is defined as a convulsive episode or altered level of consciousness occurring in the setting of preeclampsia, provided that there is no other cause of seizures...
July 2017: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/28965414/detergent-insoluble-proteome-analysis-revealed-aberrantly-aggregated-proteins-in-human-preeclampsia-placentas
#8
Wanling Zhang, Xing Chen, Ziqi Yan, Yang Chen, Yizhi Cui, Bingjun Chen, Chujun Huang, Weiwen Zhang, Xingfeng Yin, Qing-Yu He, Fang He, Tong Wang
Preeclampsia (PE) is a placenta disease, featured by hypertension, proteinuria and other multi-organ dysfunctions, and its etiology is unclear. We and others have shown that intensive ER stress and unfolded protein response (UPR) occur in the PE placenta. In this study, we isolated detergent-insoluble proteins (DIPs) from human placenta tissues, which were enriched with protein aggregates, to characterize the placenta UPR in PE. With data-independent acquisition (DIA) mass spectrometry, we identified 2066 DIPs across all normal (n=10) and PE (n=10) placenta samples, among which 110 and 108 DIPs were significantly up- and down- regulated in PE, respectively...
October 1, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28941881/historical-evolution-of-ideas-on-eclampsia-preeclampsia-a-proposed-optimistic-view-of-preeclampsia
#9
Pierre-Yves Robillard, Gustaaf Dekker, Gérard Chaouat, Marco Scioscia, Silvia Iacobelli, Thomas C Hulsey
Eclampsia (together with epilepsy) being the first disease ever written down since the beginning of writings in mankind 5000 years ago, we will make a brief presentation of the different major steps in comprehension of Pre-eclampsia. 1) 1840. Rayer, description of proteinuria in eclampsia, 2) 1897 Vaquez, discovery of gestational hypertension in eclamptic women, 3) In the 1970's, description of the "double" trophoblastic invasion existing only in humans (Brosens & Pijnenborg,), 4) between the 1970's and the 1990's, description of preeclampsia being a couple disease...
September 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28928135/extracellular-vesicles-in-preeclampsia-evolving-contributors-to-proteinuria
#10
EDITORIAL
Elizabeth A Phipps, Eliyahu V Khankin
No abstract text is available yet for this article.
September 19, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28928008/effects-of-anti-lipid-peroxidation-of-punica-granatum-fruit-extract-in-endothelial-cells-induced-by-plasma-of-severe-pre-eclamptic-patients
#11
Isri Nasifah, Setyawati Soeharto, Mukhamad Nooryanto
BACKGROUND: Preeclampsia is a pregnancy disorder characterized by hypertension and proteinuria. This disorder involves oxidative stress and changes in endothelial homeostasis. OBJECTIVE: This study was aimed to seek whether an ethanolic extract of Punica granatum fruit inhibits 8-iso-PGFα formation and modulates nitric oxide (NO) in endothelial cells induced by plasma from pre-eclamptic patients. MATERIAL AND METHODS: Endothelial cells were cultured from human umbilical vein endothelial cells...
September 15, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28863381/natural-killer-t-cells-in-preeclampsia-an-updated-review
#12
REVIEW
Vida Hashemi, Sanam Dolati, Arezoo Hosseini, Tohid Gharibi, Shahla Danaii, Mehdi Yousefi
Preeclampsia (PE), as a pregnancy-specific syndrome, has become one of the main causes of maternal and fetal mortality worldwide and is known as a major risk factor for preterm birth. PE is typically characterized by hypertension, significant proteinuria, and an excessive maternal systemic inflammatory response. Recent evidences provide support for the notion that Natural killer T (NKT) cells (a small, but significant immunoregulatory T cell subset of human peripheral blood lymphocytes) play pivotal roles in pregnancy...
August 29, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28858979/mir-195-modulates-oxidative-stress-induced-apoptosis-and-mitochondrial-energy-production-in-human-trophoblasts-via-flavin-adenine-dinucleotide-dependent-oxidoreductase-domain-containing-protein-1-and-pyruvate-dehydrogenase-phosphatase-regulatory-subunit
#13
Hao Wang, Lanmei Zhang, Xuejiang Guo, Yang Bai, Yu-Xia Li, Jiahao Sha, Chun Peng, Yan-Ling Wang, Ming Liu
OBJECTIVE: Preeclampsia is a severe pregnancy-specific syndrome defined as newly onset hypertension and proteinuria. Abnormal placental development has been generally accepted as the initial cause of the disorder. Recently, miR-195 was identified as one of the downregulated small RNAs in preeclamptic placentas. METHODS: The potential targets of miR-195 in human trophoblast cells were screened by isobaric tags for relative and absolute quantification-based mass spectrum analysis...
August 30, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28820409/-the-role-of-angiogenic-factors-in-the-diagnostics-of-pregnancy-complicated-with-preeclampsia
#14
I Tagiyeva, S Aliyeva, S Bagirova, N Shamsadinskaya, K Agaeva
The pathophysiology of preeclampsia remains largely unknown. It has been hypothesized that placental ischemia is an early event, leading to placental production of a soluble factor or factors that cause maternal endothelial dysfunction, resulting in the clinical findings of hypertension, proteinuria, and edema. Here, we confirm that placental soluble fms-like tyrosine kinase 1 (sFlt1), an antagonist of vascular growth factor (VEGF) and placental growth factor (PIGF), is upregulated in preeclampsia, leading to increased systemic levels of sFlt1...
July 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28793357/preeclampsia
#15
José Geraldo Lopes Ramos, Nelson Sass, Sérgio Hofmeister Martins Costa
The authors review hypertensive disease during pregnancy with an academic and practical view, and using the best evidence available. This disease, which is the most important clinical disease in Brazilian pregnant women, may have its incidence reduced with prevention through the use of calcium and aspirin in pregnant women at risk. Previously, it was a disease that presented with hypertension with proteinuria, but it has now been classified with new clinical parameters besides proteinuria. Morbidity and mortality should be reduced in a continental country such as Brazil using protocols for the early treatment of complications by calculating severe outcomes in preeclampsia...
September 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28781906/cystatin-c-as-a-marker-for-renal-impairment-in-preeclampsia
#16
Apeksha Niraula, Madhab Lamsal, Nirmal Baral, Shankar Majhi, Seraj Ahmed Khan, Pritha Basnet, Kashyap Dahal
Preeclampsia is a devastating pregnancy-associated disorder characterized by the onset of hypertension, proteinuria, and edema with limited plausible pathophysiology known. Cystatin-C, a novel marker for the detection of renal impairment, is increased in preeclampsia at an early stage. This study was aimed to evaluate the diagnostic efficiency of Cystatin-C as an early marker of renal function in preeclampsia comparing it to the traditional renal markers. A hospital based comparative cross-sectional study was performed on 104 women (52 diagnosed cases of preeclampsia and 52 healthy pregnant women)...
2017: Journal of Biomarkers
https://www.readbyqxmd.com/read/28774740/cadmium-inhibits-placental-trophoblast-cell-migration-via-mirna-regulation-of-the-transforming-growth-factor-beta-tgf-%C3%AE-pathway
#17
Samira A Brooks, Rebecca C Fry
Preeclampsia (PE), a condition during pregnancy that involves high blood pressure and proteinuria, is potentially fatal to both mother and child. PE currently has no known etiology or cure but has been tied to poor placental trophoblast cell migration. Increased levels of the toxic metal cadmium (Cd) have been associated with increased risk of developing PE, as well as miRNA-associated regulation of the transforming growth factorbeta (TGF-β) pathway. Signal reprogramming of the TGF-β pathway via epigenetic mechanisms is hypothesized to modify placental trophoblast function...
August 1, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28764979/apical-periodontitis-a-predictor-variable-for-preeclampsia-a-case-control-study
#18
Navid Khalighinejad, Anita Aminoshariae, James C Kulild, Andre Mickel
INTRODUCTION: Preeclampsia (PE) is characterized by hypertension and proteinuria after the 20th week of gestation. There is an association between systemic inflammation and adverse pregnancy outcomes such as PE. Therefore, for the first time, the present study aimed to investigate the possible association between maternal apical periodontitis (AP) and PE. METHODS: In this case-control study, 50 mothers who were diagnosed with PE during pregnancy were included in the experimental group...
October 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28751269/impaired-mitochondrial-fusion-autophagy-biogenesis-and-dysregulated-lipid-metabolism-is-associated-with-preeclampsia
#19
Xiaobo Zhou, Ting-Li Han, Hong Chen, Philip N Baker, Hongbo Qi, Hua Zhang
Preeclampsia(PE) is a pregnancy complication that is diagnosed by the new onset of hypertension and proteinuria. The etiology of PE remains unclear; however, growing evidence indicates that mitochondrial impairment contributes to the pathogenesis. Therefore, we aim to investigate the function of mitochondria in the development of PE. The mitochondrial metabolome in preeclamptic (n = 11) and normal (n = 11) placentas were analyzed using Gas chromatography-mass spectrometry (GC-MS). Student's t-tests and receiver operating characteristic (ROC) curves were conducted to determine which mitochondrial metabolites differed significantly between the two groups...
October 1, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28747409/spot-urine-protein-measurements-in-normotensive-pregnancies-pregnancies-with-isolated-proteinuria-and-preeclampsia
#20
Andrea Kattah, Natasa Milic, Wendy M White, Vesna D Garovic
We performed a prospective, longitudinal study of pregnant women presenting to their first obstetrics visits to characterize the changes in spot urine protein-to-creatinine (UPCR) and albumin-to-creatinine ratios (UACR) in normotensive pregnancies, as well as identify clinical characteristics associated with isolated proteinuria and preeclampsia. We measured spot urinary albumin, protein, and creatinine at the first prenatal visit, end of the second trimester, and at delivery. In normotensive pregnancy (n=142), we found that from the beginning of pregnancy to delivery, UACR increased by a median (interquartile range (IQR)) of 14...
July 26, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
keyword
keyword
52201
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"