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https://www.readbyqxmd.com/read/29046050/immunofluorescent-characterization-of-non-myelinating-schwann-cells-and-their-interactions-with-immune-cells-in-mouse-mesenteric-lymph-node
#1
Zhongli Shi, Wayne K Greene, Philip K Nicholls, Dailun Hu, Janina E E Tirnitz-Parker, Qionglan Yuan, Changfu Yin, Bin Ma
The central nervous system (CNS) influences the immune system in a general fashion by regulating the systemic concentration of humoral substances, whereas the autonomic nervous system communicates specifically with the immune system according to local interactions. Data concerning the mechanisms of this bidirectional crosstalk of the peripheral nervous system (PNS) and immune system remain limited. To gain a better understanding of local interactions of the PNS and immune system, we have used immunofluorescent staining of glial fibrillary acidic protein (GFAP), coupled with confocal microscopy, to investigate the non-myelinating Schwann cell (NMSC)-immune cell interactions in mouse mesenteric lymph nodes...
August 7, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/29044036/-five-decades-of-coronary-artery-disease-in-iceland-data-from-the-icelandic-heart-association
#2
Karl Andersen, Thor Aspelund, Elías Freyr Gudmundsson, Kristin Siggeirsdottir, Rosa Bjork Thorolfsdottir, Gunnar Sigurdsson, Vilmundur Gudnason
Coronary artery disease has been the leading cause of death and disability in Iceland during the past decades although in recent years, malignancy has taken over that position. A steady improvement in the level of major risk factors has been evident since 1980. This trend explains 72% of the decrease in premature mortality from coronary artery disease during the past three decades. However, an opposing trend in increasing obesity and type 2 diabetes has attenuated this decline in premature deaths. Unchanged risk factor trends will lead to increasing cardiovascular mortality in the years to come...
October 2017: Læknablađiđ
https://www.readbyqxmd.com/read/29042476/the-three-dimensional-genome-regulating-gene-expression-during-pluripotency-and-development
#3
REVIEW
Guillaume Andrey, Stefan Mundlos
The precise expression of genes in time and space during embryogenesis is largely influenced by communication between enhancers and promoters, which is propagated and governed by the physical proximity of these elements in the nucleus. Here, we review how chromatin domains organize the genome by guiding enhancers to their target genes thereby preventing non-specific interactions with other neighboring regions. We also discuss the dynamics of chromatin interactions between enhancers and promoters, as well as the consequent changes in gene expression, that occur in pluripotent cells and during development...
October 15, 2017: Development
https://www.readbyqxmd.com/read/29042186/bacterial-biofilm-and-associated-infections
#4
REVIEW
Muhsin Jamal, Wisal Ahmad, Saadia Andleeb, Fazal Jalil, Muhammad Imran, Muhammad Asif Nawaz, Tahir Hussain, Muhammad Ali, Muhammad Rafiq, Muhammad Atif Kamil
Microscopic entities, microorganisms that drastically affect human health need to be thoroughly investigated. A biofilm is an architectural colony of microorganisms, within a matrix of extracellular polymeric substance that they produce. Biofilm contains microbial cells adherent to one-another and to a static surface (living or non-living). Bacterial biofilms are usually pathogenic in nature and can cause nosocomial infections. The National Institutes of Health (NIH) revealed that among all microbial and chronic infections, 65% and 80%, respectively, are associated with biofilm formation...
October 14, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29041899/how-effective-are-family-based-and-institutional-nutrition-interventions-in-improving-children-s-diet-and-health-a-systematic-review
#5
Andrew P Black, Katina D'Onise, Robyn McDermott, Hassan Vally, Kerin O'Dea
BACKGROUND: Effective strategies to improve dietary intake in young children are a priority to reduce the high prevalence of chronic non-communicable diseases in adulthood. This study aimed to assess the impact of family-based and school/preschool nutrition programs on the health of children aged 12 or younger, including the sustainability of these impacts and the relevance to socio-economic inequalities. METHODS: A systematic review of literature published from 1980 to December 2014 was undertaken...
October 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29038389/association-of-glomerular-filtration-rate-with-cardiometabolic-risk-factors-in-iranian-adolescents-caspian-iii-study
#6
Ramin Tajbakhsh, Ramin Heshmat, Saeid Safiri, Mahya Vafaeenia, Mohammad Esmaeil Motlagh, Morteza Mansourian, Shaghayegh Beshtar, Omid Safari, Hamid Asayesh, Hossein Ansari, Mostafa Qorbani, Roya Kelishadi
INTRODUCTION: This study aimed to assess the association of glomerular filtration rate (GFR) with cardiometabolic risk factors in Iranian adolescents. MATERIALS AND METHODS: Data of the 3rd round of a school-based surveillance system entitled "Childhood and Adolescence Surveillance and PreventIon of Adult Non-communicable Disease (CASPIAN III)" study was used for this study. A sample of 367 adolescents aged between 10 and 18 years was randomly selected. Glomerular filtration rate was estimated using the original and the updated Schwartz equations...
October 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29037273/determinants-of-takeaway-and-fast-food-consumption-a-narrative-review
#7
Hayley G Janssen, Ian G Davies, Lucinda D Richardson, Leonard Stevenson
Out-of-home foods (takeaway, take-out and fast foods) have become increasingly popular in recent decades and are thought to be a key driver in increasing levels of overweight and obesity due to their unfavourable nutritional content. Individual food choices and eating behaviours are influenced by many interrelated factors which affect the results of nutrition-related public health interventions. While the majority of research based on out-of-home foods comes from Australia, the UK and USA, the same issues (poor dietary habits and increased prevalence of non-communicable disease) are of equal concern for urban centres in developing economies undergoing 'nutrition transition' at a global scale...
October 17, 2017: Nutrition Research Reviews
https://www.readbyqxmd.com/read/29036781/transport-on-prescription-how-can-gps-contribute-to-the-promotion-of-active-transport
#8
Chance Pistoll, John Furler
BACKGROUND: Active transport (ie walking, cycling, using public transport) can play a part in reducing non-communicable diseases (NCDs). Very little is known about how general practitioners (GPs) can contribute to promoting active transport. We explored GPs' ideas around active transport, and potential barriers and facilitators to its promotion in the clinical setting. METHODS: Using a maximal variation sample, we conducted 10 semi-structured interviews with GPs in Victoria, Australia...
October 2017: Australian Family Physician
https://www.readbyqxmd.com/read/29036177/dietary-patterns-in-internal-migrants-in-a-continental-country-a-population-based-study
#9
Antonio Augusto Ferreira Carioca, Bartira Gorgulho, Juliana Araujo Teixeira, Regina Mara Fisberg, Dirce Maria Marchioni
OBJECTIVE: The objective of this study was to assess the differences and similarities in dietary patterns among migrants and natives. METHODS: A population-based, cross-sectional study was conducted in the city of São Paulo. The study population included internal migrants, defined as individuals born outside São Paulo city who had lived in the city for ten years or longer. The final population (n = 999) was divided into three groups: natives of São Paulo (n = 354), migrants from the Southeast (n = 349) and migrants from the Northeast (n = 296)...
2017: PloS One
https://www.readbyqxmd.com/read/29035960/web-based-therapeutic-interventions-for-assessing-managing-and-treating-health-conditions-in-indigenous-people-a-scoping-review-protocol
#10
Odette Gibson, Rachel Reilly, Stephen Harfield, Catalin Tufanaru, James Ward
The objective of the scoping review is to map the international scientific literature on web-based therapeutic interventions (WBTI) used by Indigenous people for assessing, managing and treating health conditions. The focus of this review is WBTIs for a broad range of health conditions, including but not limited to, communicable and non-communicable diseases, mental health conditions (including the broader concept of social and emotional wellbeing), use of harmful substances and gambling.The questions for the scoping review are...
October 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29035315/breaking-up-sitting-with-light-intensity-physical-activity-implications-for-shift-workers
#11
Grace E Vincent, Sarah M Jay, Corneel Vandelanotte, Sally A Ferguson
Prolonged sitting, restricted sleep, and circadian disruption are all independent risk factors for non-communicable diseases. Previous research has demonstrated that breaking up sitting with light-intensity physical activity has clear benefits for the health of day workers, but these findings may not apply in the presence of sleep restriction and/or circadian disruption-both of which are commonly experienced by shift-workers. Specifically, sleep restriction, and circadian disruption result in acute physiological changes that may offset the benefits of breaking up sitting...
October 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29033828/perspective-insights-of-exosomes-in-neurodegenerative-diseases-a-critical-appraisal
#12
REVIEW
Arif Tasleem Jan, Mudasir A Malik, Safikur Rahman, Hye R Yeo, Eun J Lee, Tasduq S Abdullah, Inho Choi
Exosomes are small membranous entities of endocytic origin. Their production by a wide variety of cells in eukaryotes implicates their roles in the execution of essential processes, especially cellular communication. Exosomes are secreted under both physiological and pathophysiological conditions, and their actions on neighboring and distant cells lead to the modulations of cellular behaviors. They also assist in the delivery of disease causing entities, such as prions, α-syn, and tau, and thus, facilitate spread to non-effected regions and accelerate the progressions of neurodegenerative diseases...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29032863/measuring-the-quality-of-personal-care-in-patients-undergoing-radiotherapy-for-prostate-cancer
#13
K A Foley, P A Groome, D Feldman-Stewart, M D Brundage, J H Foley, S McArdle, W J Mackillop
AIMS: To describe the quality of the non-technical component of the care (personal care) of patients receiving radical radiotherapy for prostate cancer and to identify elements of personal care that should be priorities for quality improvement. MATERIALS AND METHODS: One hundred and eight patients undergoing radiotherapy for localised prostate cancer completed a self-administered questionnaire that asked them to rate the importance of 143 non-technical elements of care and to rate the quality of their own care with respect to each element...
October 9, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29030159/obstructive-m%C3%A3-llerian-anomalies-in-menstruating-adolescent-girls-a-report-of-22-cases
#14
Karina Kapczuk, Zbigniew Friebe, Kinga Iwaniec, Witold Kędzia
STUDY OBJECTIVE: To assess the clinical course of obstructive Müllerian anomalies found in girls after menarche DESIGN: A retrospective case series of adolescents who between 2009 and 2016 were treated for vaginal or uterine obstructive malformations diagnosed after menarche SETTING: Division of Gynecology, Poznań University of Medical Sciences, Poznań, Poland PARTICIPANTS: Twenty-two patients who, at the age of 11.4-18.2 (median 13.1) years, between 2 and 74 (median 7.5) months after menarche, underwent surgical repair of obstructive genital anomaly MAIN OUTCOME MEASURES: Müllerian defect type, presentation, radiologic findings, pre- and postoperative course RESULTS: Eighteen patients (81...
October 10, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29029799/interdependent-and-independent-multidimensional-role-of-tumor-microenvironment-on-hepatocellular-carcinoma
#15
REVIEW
Xue Wang, Waseem Hassan, Qaiser Jabeen, Ghulam Jilany Khan, Furqan Iqbal
The novelty of an effective therapeutic targeting for hepatocellular carcinoma (HCC) is based on improved understanding of each component of tumor microenvironment (TME) and its correspondent interactions at biological and molecular levels. In this context, new expansions for the treatment against TME and its communication with HCC are under exploration. Despite of the fact that blockage of growth factor receptors has become a treatment of choice in late phases of HCC in clinical practice, still a precise targeted treatment should address all the components of TME...
October 10, 2017: Cytokine
https://www.readbyqxmd.com/read/29029103/cardiovascular-disease-prevention-policy-in-hiv-recommendations-from-a-modelling-study
#16
Mikaela Smit, Rosan A van Zoest, Brooke E Nichols, Ilonca Vaartjes, Colette Smit, Marc van der Valk, Ard van Sighem, Ferdinand W Wit, Timothy B Hallett, Peter Reiss
Background: Cardiovascular disease (CVD) is expected to contribute a large non-communicable disease burden amongst HIV-positive people. We quantify the impact of prevention interventions on annual CVD burden and costs amongst HIV-positive people in The Netherlands. Methods: We constructed an individual-based model of CVD in HIV-positive people using national ATHENA cohort data on 8,791 patients on combination antiretroviral therapy (cART). The model follows patients as they age, develop CVD (by incorporating a CVD risk equation) and start cardiovascular medication...
October 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29026406/grappling-with-mother-newborn-and-child-health-mnch-issues-in-a-continent-beset-by-non-communicable-and-infecious-diseases
#17
EDITORIAL
J K Tumwine
No abstract text is available yet for this article.
March 2017: African Health Sciences
https://www.readbyqxmd.com/read/29025826/patient-characteristics-of-the-accident-and-emergency-department-of-kenyatta-national-hospital-nairobi-kenya-a-cross-sectional-prospective-analysis
#18
Justin Guy Myers, Katherine M Hunold, Karen Ekernas, Ali Wangara, Alice Maingi, Vincent Mutiso, Stephen Dunlop, Ian B K Martin
BACKGROUND: Resource-limited settings are increasingly experiencing a 'triple burden' of disease, composed of trauma, non-communicable diseases (NCDs) and known communicable disease patterns. However, the epidemiology of acute and emergency care is not well characterised and this limits efforts to further develop emergency care capacity. OBJECTIVE: To define the burden of disease by describing the patient population presenting to the Accident and Emergency Department (A&E) at Kenyatta National Hospital (KNH) in Kenya...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/29025610/is-endoprosthesis-safer-than-internal-fixation-for-metastatic-disease-of-the-proximal-femur-a-systematic-review
#19
Alberto Di Martino, Nicolò Martinelli, Mattia Loppini, Andrea Piccioli, Vincenzo Denaro
INTRODUCTION: Metastases to the proximal femur are usually managed surgically by tumor resection and reconstruction with an endoprosthesis, or by fixation with osteosynthesis. Still controversy remains regarding the most appropriate surgical treatment. We posed the following questions: (1) Is the frequency of surgical revision greater in patients treated with internal fixation than endoprosthetic reconstruction, and (2) Do complications that do not require surgery occur more frequently in patients treated with internal fixation rather than in those with endoprosthetic reconstruction? MATERIALS AND METHODS: A systematic review was performed of those studies reporting on surgical revision and complication rates comparing the two surgical methods...
October 2017: Injury
https://www.readbyqxmd.com/read/29025446/inefficient-procurement-processes-undermine-access-to-medicines-in-the-western-cape-province-of-south-africa
#20
Bvudzai P Magadzire, Kim Ward, Henry M J Leng, David Sanders
BACKGROUND: South Africa (SA) has experienced several stock-outs of life-saving medicines for the treatment of major chronic infectious and non-communicable diseases in the public sector. OBJECTIVE: To identify the causes of stock-outs and to illustrate how they undermine access to medicines (ATM) in the Western Cape Province, SA. METHODS: This qualitative study was conducted with a sample of over 70 key informants (frontline health workers, sub-structure and provincial health service managers)...
June 30, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
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