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Wen-Xu Jin, Dan-Rong Ye, Yi-Han Sun, Xiao-Fen Zhou, Ou-Chen Wang, Xiao-Hua Zhang, Ye-Feng Cai
Background: Preoperative diagnosis of central lymph node metastasis (CLNM) poses to be a challenge in clinical node-negative papillary thyroid microcarcinoma (PTMC). This research work aims at investigating the association existing between BRAF mutation, clinicopathological factors, ultrasound characteristics, and CLNM, in addition to establishing a predictive model for CLNM in PTMC. Materials and methods: The study included 673 PTMC patients, already undergone total thyroidectomy or lobectomy with prophylactic central lymph node dissection...
2018: Cancer Management and Research
Rakesh K Gupta, Vineeta V Batra, Daljit Singh, Mehar C Sharma, Vikas Kumar
Spindle cell oncocytoma (SCO) is a newly described rare entity simulating clinicoradiological features of a nonfunctional pituitary adenoma and is corresponding to the category of World Health Organization grade I tumor. However, because of the reported incidence of recurrence and invasive presentation in some cases, its categorization as a low grade tumor is questionable. Earlier, it was thought to arise from the folliculostellate cells of adenohypophysis. Recently, few reports have described expression of thyroid transcription factor-1 [TTF-1], which is a specific marker for pituicytes of neurohypophysis, suggesting this tumor to be a variant of pituicytoma...
September 2018: Neurology India
Tsubasa Aiyoshi, Toshihiro Muraji, Isho Izumi, Miki Toma, Kazuto Suda, Toshihiro Yanai, Kouji Masumoto
BACKGROUND: Currently, there is no consensus regarding the optimal therapeutic strategy for the management of an ectopic lingual thyroid. A surgical approach is suggested when airway obstructive symptoms cannot be tolerated at all, or when bleeding or malignancy occurs. However, for patients in whom ectopic thyroid is the only functioning thyroid tissue, complete surgical excision needs to be followed by lifelong hormone replacement therapy. We report the case of an infant with ectopic lingual thyroid obstructing the airway that was treated using our novel surgical procedure...
September 19, 2018: Surgical Case Reports
Guoshuang Shen, Fangchao Zheng, Dengfeng Ren, Feng Du, Qiuxia Dong, Ziyi Wang, Fuxing Zhao, Raees Ahmad, Jiuda Zhao
Anlotinib is a new, orally administered tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptors (PDGFR), and c-kit. Compared to the effect of placebo, it improved both progression-free survival (PFS) and overall survival (OS) in a phase III trial in patients with advanced non-small-cell lung cancer (NSCLC), despite progression of the cancer after two lines of prior treatments. Recently, the China Food and Drug Administration (CFDA) approved single agent anlotinib as a third-line treatment for patients with advanced NSCLC...
September 19, 2018: Journal of Hematology & Oncology
R S Du Puy, I Postmus, D J Stott, M R Blum, R K E Poortvliet, W P J Den Elzen, R P Peeters, B C van Munster, B H R Wolffenbuttel, R G J Westendorp, P M Kearney, I Ford, S Kean, C M Messow, T Watt, J W Jukema, O M Dekkers, J W A Smit, N Rodondi, J Gussekloo, S P Mooijaart
BACKGROUND: Subclinical hypothyroidism is common in older people and its contribution to health and disease needs to be elucidated further. Observational and clinical trial data on the clinical effects of subclinical hypothyroidism in persons aged 80 years and over is inconclusive, with some studies suggesting harm and some suggesting benefits, translating into equipoise whether levothyroxine therapy provides clinical benefits. This manuscript describes the study protocol for the Institute for Evidence-Based Medicine in Old Age (IEMO) 80-plus thyroid trial to generate the necessary evidence base...
September 19, 2018: BMC Endocrine Disorders
Charles A Kunos, Jacek Capala
Radiopharmaceutical therapies have provided an attractive therapeutic approach since the introduction of 131 I to treat thyroid cancer. New insights in cancer biology and radiochemistry have brought radiopharmaceuticals to the leading edge of oncology clinical research. National Cancer Institute (NCI) programs watch for new radiopharmaceutical breakthroughs that should be used to treat patients with unmet therapeutic needs. Such efforts occur through leveraged partnerships between NCI's Cancer Therapy Evaluation Program and its Radiation Research Program...
May 23, 2018: American Society of Clinical Oncology Educational Book
Yasuhiro Ito, Akira Miyauchi
Papillary thyroid microcarcinoma (PMC) is defined as papillary thyroid carcinoma ≤10 mm. Active surveillance of PMC without high-risk features, such as clinical node metastasis, distant metastasis, and clinical evidence of significant extrathyroid extension, was initiated in two Japanese hospitals in the mid-1990s. This strategy was incorporated into guidelines in Japan in 2010 and in the United States in 2015. In studies conducted by the two hospitals, most PMCs grew very slowly or did not grow, and none of the patients during active surveillance showed distant metastasis or died of thyroid carcinoma...
September 19, 2018: Annual Review of Medicine
Shiro Kimbara, Yutaka Fujiwara, Shintaro Iwama, Ken Ohashi, Aya Kuchiba, Hiroshi Arima, Naoya Yamazaki, Shigehisa Kitano, Noboru Yamamoto, Yuichiro Ohe
Thyroid dysfunction (TD) induced by immune checkpoint inhibitors is not sufficiently understood. The purpose of this retrospective observational study was to identify risk factors and the clinical course of TD induced by nivolumab. Patients with advanced solid tumors who were treated with nivolumab from March 2009 through March 2016 at the National Cancer Center Hospital were included. Thyroid function and anti-thyroid antibodies from serum samples among all patients were evaluated at baseline and during nivolumab treatment...
September 19, 2018: Cancer Science
Sara J Brandt, Timo D Müller, Richard D DiMarchi, Matthias H Tschöp, Kerstin Stemmer
Obesity and its comorbidities, such as type 2 diabetes, are pressing worldwide health concerns. Available anti-obesity treatments include weight loss pharmacotherapies and bariatric surgery. While surgical interventions typically result in significant and sustained weight loss, available pharmacotherapies are far less effective, typically decreasing body weight by no more than 5 - 10%. An emerging class of multiagonist drugs may eventually bridge this gap. This new class of specially-tailored drugs hybridizes the amino acid sequences of key metabolic hormones into one single entity with enhanced potency and sustained action...
September 19, 2018: Journal of Internal Medicine
Olivier Brandenberger, Ann Martens, Céline Robert, Peter Wiemer, Hugo Pamela, Lieven Vlaminck, Katerina Barankova, Maarten Haspeslagh, Justin D Perkins, Norm Ducharme, Fabrice Rossignol
OBJECTIVE: To describe the anatomy of the entry to the equine esophagus (vestibulum esophagi) and to assess the risk of penetrating its adventitia and/or lumen during laryngoplasty. STUDY DESIGN: Ex vivo cadaveric study. SAMPLE POPULATION: Five isolated equine larynges and 39 equine head and neck specimens. METHODS: The anatomy of the vestibulum esophagi was studied by dissection of 5 cadaver specimens. Then, a bilateral laryngoplasty was performed, including 5 suture placements through the muscular processes, caudal, rostral, and sagittal, with straight and curved needles...
September 19, 2018: Veterinary Surgery: VS
Larry F Ellison
BACKGROUND: Monitoring the progress of cancer survival in a population over time is an important part of cancer surveillance. DATA AND METHODS: Data are from the Canadian Cancer Registry with mortality follow-up through record linkage to the Canadian Vital Statistics Death Database and tax files. Net survival (NS) was derived using the Pohar Perme method. Predicted estimates of NS for the period from 2012 to 2014 were calculated using the period method. Age-standardized and age-specific changes in five-year NS between the periods from 1992 to 1994 and 2012 to 2014 were determined for 30 individual cancers...
September 19, 2018: Health Reports
Camilla Costa, Ricardo Garcia Pastorello, André Mendonça, Caroline Tamaro, Caroline Morais, Barbara Barbosa, Karina Braga Ribeiro, Alessandra Caivano, Mauro Ajaj Saieg
BACKGROUND: Rapid on-site evaluation is a great tool for optimizing the adequacy and quality of cytologic samples. The objective of the current study was to analyze a low-cost telecytopathology method for the remote assessment of thyroid fine-needle aspiration biopsies (FNABs), with comparison of the primarily rendered adequacy and diagnosis with the final conventional analysis. METHODS: Material collected from thyroid FNABs was immediately smeared onto glass slides and stained with Diff-Quik...
September 19, 2018: Cancer Cytopathology
Tamar C Brandler, Margaret Cho, Xiao-Jun Wei, Anthony Simms, Pascale Levine, Osvaldo Hernandez, Thaira Oweity, Fang Zhou, Aylin Simsir, Lisa Rosen, Wei Sun
OBJECTIVE: Because of the indolent nature of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) and potential requisite for conservative treatment, it is crucial to identify features of this entity pre-operatively. Our group recently published our findings that there are several cytomorphologic features that may be used as clues to distinguish NIFTP, PTC and follicular adenoma (FA) on fine-needle aspiration (FNA). Therefore, we aimed to determine the interobserver reproducibility of these findings...
September 19, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Shiqian Hu, Yue Wang, Mingqian He, Meng Zhang, Xi Ding, Bingyin Shi
OBJECTIVE: Intravenous methylprednisolone (IVMP) is recommended as the first-line treatment for moderate-to-severe and active thyroid-associated ophthalmopathy (TAO). This study aimed to identify potential predictors and establish a multivariable prediction model for the efficacy of IVMP therapy. DESIGN: A single-center retrospective study. PATIENTS: A total of 302 consecutive patients diagnosed with moderate-to-severe and active TAO who underwent the full course of IVMP therapy were included...
September 19, 2018: Clinical Endocrinology
Suttikarn Santiwatana, Pat Mahachoklertwattana, Chanin Limwongse, Patcharin Khlairit, Sarunyu Pongratanakul, Ekkapong Roothumnong, Kanjana Prangphan, Lulin Choubtum, Duantida Songdej, Preamrudee Poomthavorn
OBJECTIVE: Skewed X chromosome inactivation (XCI) was associated with female predominance in adult autoimmune thyroid disease (ATD). In normal females, skewed XCI is increased with age. Whether early-onset skewed XCI is associated with childhood ATD remains unknown. This study aimed to determine XCI skewing in paediatric ATD. DESIGN, PATIENTS AND MEASUREMENTS: Ninety-one female ATD patients, aged 3-20 years and 57 age-matched, female controls were enrolled. XCI was analysed by enzymatic digestion of DNA with methylation-sensitive enzymes followed by PCR of the polymorphic CAG repeat in the androgen receptor gene...
September 19, 2018: Clinical Endocrinology
Braira Wahid, Muhammad Waqar, Nouman Rasool, Muhammad Wasim, Ifrah Khalid, Muhammad Idrees
Thyroid dysfunctions occur frequently among HCV infected patients. Accumulating evidence have shown the higher incidence of thyroid dysfunctions in interferon treated patients that was previously the standard of care therapy. However, the prevalence of thyroid disorders haven't been studied in the recently developed interferon-free regimens or direct-acting anti-viral (DAA) drugs treated patients. We recruited 37 patients who had just completed 6 months-long sofosbuvir-based treatment and 26 interferon-treated patients were also included in the study...
September 19, 2018: Journal of Medical Virology
Yoojin Noh, Sang-Min Jeon, Sooyoung Shin
Preclinical data suggested that dipeptidyl peptidase-4 (DPP-4) inhibitors may promote metastatic progression of preexisting cancer via nuclear factor erythroid 2 related factor 2 (NRF2) activation. We aimed to investigate the association between different glucose-lowering treatments, including DPP-4 inhibitors and metformin, both with potential NRF2 modulating effects, and new-onset metastatic cancer among type 2 diabetes patients with comorbid incident cancer. This population-based cohort study included 223,530 diabetic patients newly diagnosed with primary cancer during 2009-2011 in Korea...
September 19, 2018: International Journal of Cancer. Journal International du Cancer
H-W Lu, X-D Liu
OBJECTIVE: To explore whether lncRNA UCA1 (long non-coding RNA urothelial carcinoma associated 1) could promote the development of papillary thyroid carcinoma (PTC) via Wnt pathway and its underlying mechanism. PATIENTS AND METHODS: UCA1 expression in PTC tissues, paracancerous tissues, and thyroid cancer cells were detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). UCA1 lentivirus was then constructed for the following in vitro experiments...
September 2018: European Review for Medical and Pharmacological Sciences
X-B Gao, C-L Chen, Z-L Tian, F-K Yuan, G-L Jia
OBJECTIVE: To investigate the significance and possible mechanism of miR-791 in the pathogenesis of papillary thyroid carcinoma (PTC). PATIENTS AND METHODS: The expression of miR-791 in 80 cases of thyroid carcinoma tissues and 80 cases of paracancerous tissues was detected by quantitative Real-time-polymerase chain reaction (qRT-PCR). After miR-791 mimics were transfected into thyroid cancer cells by liposome method, the cell proliferation was detected by Cell Counting Kit-8 (CCK-8) and 5-ethynyl-2'-deoxyuridine (EDU), respectively...
September 2018: European Review for Medical and Pharmacological Sciences
Young Ah Lee, Sun Wook Cho, Ho Kyung Sung, Kyungsik Kim, Young Shin Song, Sin Je Moon, Jung Won Oh, Dal Lae Ju, Sooyeon Choi, Sang Hoon Song, Gi Jeong Cheon, Young Joo Park, Choong Ho Shin, Sue K Park, Jong Kwan Jun, June Key Chung
BACKGROUND: Iodine is an intrinsic element of thyroid hormone, which is essential for childhood growth and development. The Ideal Breast Milk (IBM) cohort study aims to evaluate the effects of maternal iodine status during pregnancy and lactation on maternal thyroid function, offspring growth and development, and offspring thyroid function. METHODS: The IBM cohort study recruited pregnant women from Seoul National University Hospital between June 2016 and August 2017, followed by enrollment of their offspring after delivery...
September 2018: Endocrinology and Metabolism
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