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https://www.readbyqxmd.com/read/29913483/the-associations-between-the-growth-hormone-insulin-like-growth-factor-1-axis-adiponectin-resistin-and-metabolic-profile-in-children-with-growth-hormone-deficiency-before-and-during-growth-hormone-treatment
#1
Ewelina Witkowska-Sędek, Małgorzata Rumińska, Anna Stelmaszczyk-Emmel, Anna Majcher, Beata Pyrżak
This study investigated associations between the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis, adiponectin, resistin and metabolic profile in 47 GH-deficient children before and during 12 months of GH treatment. 23 short age-matched children without growth hormone deficiency (GHD) or any genetic or chronic disorders were recruited as controls at baseline. Metabolic evaluation included measurements of adiponectin, resistin, IGF-1, total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), glucose, insulin, glycated haemoglobin (HbA1c), thyroid stimulating hormone (TSH) and free thyroxine (free T4) concentrations...
2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29913170/seasonal-changes-in-plasma-concentrations-of-the-thyroid-glucocorticoid-and-reproductive-hormones-in-the-tegu-lizard-salvator-merianae
#2
Lucas A Zena, Danielle Dillon, Kathleen E Hunt, Carlos A Navas, Kênia C Bícego, C Loren Buck
The tegu lizard Salvator merianae is a large, widely distributed teiid lizard endemic to South America that exhibits annual cycles of high activity during the spring and summer, and hibernation during winter. This pattern of activity and hibernation is accompanied by profound seasonal changes in physiology and behavior, including endothermy during the austral spring. The unusual combination of seasonal endothermy, hibernation and oviparity, in a non-avian, non-mammalian species, makes S. merianae an interesting subject for study of comparative aspects of endocrine regulation of seasonal changes in physiology...
June 15, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29912597/cystatin-c-as-a-predictor-of-mortality-in-elderly-patients-with-chronic-kidney-disease
#3
Sebastjan Bevc, Nina Hojs, Maša Knehtl, Robert Ekart, Radovan Hojs
BACKGROUND: The prevalence of chronic kidney disease (CKD) in the elderly is high. Serum cystatin C is an accurate marker of kidney function and it also has prognostic utility in CKD patients. The aim of our study was to determine the prediction of serum cystatin C and other markers of kidney function on long-term survival in elderly CKD patients. METHODS: Fifty eight adult Caucasian patients, older than 65 years, without known malignancy, thyroid disease and/or not on steroid therapy were enrolled in the study...
June 18, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29912343/impact-on-testicular-function-of-a-single-ablative-activity-of-3-7-gbq-radioactive-iodine-for-differentiated-thyroid-carcinoma
#4
N Bourcigaux, C Rubino, I Berthaud, M E Toubert, B Donadille, L Leenhardt, I Petrot-Keller, S Brailly-Tabard, J Fromigué, F de Vathaire, T Simon, J P Siffroi, M Schlumberger, P Bouchard, S Christin-Maitre
STUDY QUESTION: What are the consequences of radioactive iodine (RAI) therapy for testicular function? SUMMARY ANSWER: A single activity of 3.7 GBq RAI for differentiated thyroid carcinoma (DTC) treatment in young men transiently altered Sertoli cell function and induced sperm chromosomal abnormalities. WHAT IS KNOWN ALREADY: Few studies, mainly retrospective, have reported the potential impacts of RAI on endocrine and exocrine testicular function...
June 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29912274/selective-ret-kinase-inhibition-for-patients-with-ret-altered-cancers
#5
V Subbiah, V Velcheti, B B Tuch, K Ebata, N L Busaidy, M E Cabanillas, L J Wirth, S Stock, S Smith, V Lauriault, S Corsi-Travali, D Henry, M Burkard, R Hamor, K Bouhana, S Winski, R D Wallace, D Hartley, S Rhodes, M Reddy, B J Brandhuber, S Andrews, S M Rothenberg, A Drilon
Purpose: Alterations involving the RET kinase are implicated in the pathogenesis of lung, thyroid and other cancers. However, the clinical activity of multikinase inhibitors with anti-RET activity in RET-altered patients appears limited, calling into question the therapeutic potential of targeting RET. LOXO-292 is a selective RET inhibitor designed inhibit diverse RET fusions, activating mutations and acquired resistance mutations. Patients and Methods: Potent anti-RET activity, high selectivity, and central nervous system coverage were confirmed preclinically using a variety of in vitro and in vivo RET-dependent tumor models...
April 18, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29911397/transient-hyperthyroidism-induced-by-thyroid-ultrasound
#6
Rajini K Yatavelli, Steven N Levine
OBJECTIVES: Transient hyperthyroidism has been documented following surgical manipulation or direct trauma to the normal thyroid gland. This has best been studied in patients following parathyroidectomy and also reported following trauma to the neck, strangulation, and vigorous palpation of the thyroid gland. It has not previously been reported following a thyroid ultrasound. METHODS: We report the case of a 58-year-old euthyroid woman with a large nontoxic multinodular goiter who developed transient hyperthyroidism following an ultrasound of the thyroid gland...
June 1, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29911396/epidemiology-of-swallowing-disorders-in-rheumatoid-arthritis-prevalence-risk-factors-and-quality-of-life-burden
#7
Nelson Roy, Kristine M Tanner, Ray M Merrill, Charisse Wright, Jenny L Pierce, Karla L Miller
OBJECTIVE: This investigation examined the prevalence, symptoms, risk factors, and quality-of-life burden of swallowing disorders in rheumatoid arthritis (RA), a chronic, progressive autoimmune inflammatory disease. METHODS: One hundred individuals with RA (84 women, 16 men; mean age = 61.1 years, SD = 13.1) were interviewed regarding the presence, nature, and impact of swallowing symptoms and disorders. Associations between swallowing disorders, medical factors, RA disease severity, and quality of life were examined...
June 1, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29911049/indeterminate-thyroid-nodule-mystery-continues-despite-recent-advances
#8
Ameya Joshi, Ritesh Agrawal
No abstract text is available yet for this article.
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29911047/the-goitrous-salting-madonnas-iconography-of-goiter-in-religious-portraits
#9
Davide Lazzeri, Fabio Nicoli
Introduction: George Salting was an art collector, who bequeathed his collection of paintings to the National Gallery of London. The present investigation has revealed five portraits of five different artists belonging to this collection in which the Holy Mother holding the child has been portrayed with a variable grade of thyroid gland enlargement. The name Salting, applied to the Madonnas with child by Antonello da Messina, Robert Campin, Dirk Bouts, Cima da Conegliano, and Andrea del Verrocchio, denotes George Salting, the collector who donated the masterworks to the gallery in 1910...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29911045/congenital-hypothyroidism-screening-in-term-neonates-using-umbilical-cord-blood-tsh-values
#10
Ravi Bhatia, Dinesh Rajwaniya
Congenital hypothyroidism remains one of the most common preventable causes of mental retardation among children. Screening for congenital hypothyroidism remains one of the most cost-effective tools to prevent mental retardation in the population. Umbilical cord blood thyroid-stimulating hormone (TSH) levels remain an attractive and a practical step for screening for congenital hypothyroidism. The aims of this study were as follows: (1) to find normative values of cord blood TSH for the study group and (2) to use cord blood TSH levels as a marker for screening of congenital hypothyroidism...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29911027/is-a-surgeon-performed-ultrasound-good-enough-in-diagnosing-thyroid-malignancy
#11
Gajarajan Mohanapriya, Maharajan Chandrasekaran
Background: The widespread availability of ultrasonography has facilitated the evaluation of thyroid nodules, to differentiate between malignant and benign nodules and between metastatic and reactive lymph nodes. From the radiologists' suite, ultrasound has moved into the surgeon's office. Aim: The aim of the present study was to evaluate the relevance of surgeon-performed ultrasound (SPUS) in the diagnosis of malignancy of the thyroid. Methods: SPUS for 389 consecutive patients attending the outpatient department of endocrine surgery in a tertiary care institute in Chennai...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29911026/extending-the-clinician-s-hand-through-thyroid-ultrasound-do-it-yourself-for-the-uninitiated-busts-expertise
#12
EDITORIAL
Krishna G Seshadri
No abstract text is available yet for this article.
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29911021/-mycobacterium-avium-subspecies-paratuberculosis-a-possible-causative-agent-in-human-morbidity-and-risk-to-public-health-safety
#13
REVIEW
Mary Garvey
Mycobacterium avium subspecies paratuberculosis is a bacterial parasite and the causative agent of paratuberculosis, a disease predominately found in cattle and sheep. Infection with this microorganism results in substantial farming economic losses and animal morbidity. The link between infection with this pathogen and human disease has been theorised for many years with Crohn's disease being one of many suspected resultant conditions. Mycobacterium avium may be spread from animal to human hosts by water and foodborne transmission routes, where the foodborne route of exposure represents a significant risk for susceptible populations, namely children and the immune-compromised...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/29910736/thyroid-hormones-play-role-in-sarcopenia-and-myopathies
#14
Flavia F Bloise, Thamires S Oliveira, Aline Cordeiro, Tania M Ortiga-Carvalho
Skeletal muscle maintains posture and enables movement by converting chemical energy into mechanical energy, further contributing to basal energy metabolism. Thyroid hormones (thyroxine, or T4, and triiodothyronine, or T3) participate in contractile function, metabolic processes, myogenesis and regeneration of skeletal muscle. T3 classically modulates gene expression after binding to thyroid hormone nuclear receptors. Thyroid hormone effects depend on nuclear receptor occupancy, which is directly related to intracellular T3 levels...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29910553/thyrotoxic-hypokalemic-periodic-paralysis
#15
Satyendra Kumar Sonkar, Satish Kumar, Neeraj Kumar Singh
Hypokalemia is a serious and life-threatening clinical condition. We present a case of a 45-year-old male, with known hyperthyroidism presenting with profound tremor, irritability, quadriparesis, and labored breathing since morning, on the day of admission. Arterial blood gas analysis showed severe hypokalemia. Patient's vital was stabilized and patient's oxygen saturation was maintained on oxygen inhalation. Intravenous potassium chloride infusion was administered with regular monitoring of vitals and electrolytes...
May 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29910183/rhabdomyolysis-in-a-patient-complicated-with-hypopituitarism-and-multiple-organ-dysfunction-syndrome-and-the-literature-review
#16
Chuan Zhou, Shichao Lai, Yong Xie, Shu Zhang, Yiping Lu
INTRODUCTION: Muscular symptoms, including stiffness, myalgia, cramps, and fatigue, are present in the majority of the patients with hypopituitarism, adrenal insufficiency and hypothyroidism, but rhabdomyolysis, the rapid breakdown of skeletal muscle, is a rare manifestation. In most patients who develop rhabdomyolysis, precipitating factors, such as strenuous exercise or use of lipid-lowering drugs, can be identified. CASE REPORT: We report the case of a 23-year-old male with primary hypopituitarism who developed acute renal impairment (AKI) with rhabdomyolysis after strenuous physical activity (push-ups)...
June 7, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29910160/influence-of-thyroid-peroxidase-antibodies-on-tsh-levels-of-pregnant-women-and-maternal-fetal-complications
#17
Paula Fernández Martínez, Rocío Aguado García, David Emilio Barajas Galindo, Ana Hernández Moreno, Mirian Alejo Ramos, Sara García Arias, María D Ballesteros Pomar, Isidoro Manuel Cano Rodríguez
INTRODUCTION: During pregnancy, thyroid peroxidase (TPO) antibodies may increase the risk of developing subclinical hypothyroidism (SCH). Both conditions appear to be associated to maternal-fetal complications. The objectives of this study were to analyze if a relationship exists between TSH and TPO levels during pregnancy and the potential effects on gestational and perinatal complications, and to assess whether detectable, but not positive, TPO levels have an impact on development of gestational SCH...
June 14, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29910159/nivolumab-induced-thyroid-dysfunction-in-patients-with-lung-cancer
#18
Ana M Ramos-Levi, Jacobo Rogado, Jose Miguel Sanchez-Torres, Ramón Colomer, Mónica Marazuela
BACKGROUND: Nivolumab is an anti-cancer monoclonal antibody that inhibits PD1 and modulates T-cell response. It has been shown to significantly improve survival in several types of cancer, but clinical trials have also reported an increased risk of developing immune-related adverse events (IRAEs). Endocrine IRAEs may be particularly relevant. OBJECTIVE: To comprehensively evaluate the clinical presentation of endocrine IRAEs in patients with lung cancer treated with nivolumab...
June 14, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29909901/primary-thyroid-angiosarcoma-a-systematic-review
#19
REVIEW
F De Felice, E Moscatelli, S Orelli, N Bulzonetti, D Musio, V Tombolini
Thyroid angiosarcoma (TAS) is rare and represents a very aggressive malignancy. Its rarity is principally linked to two major pitfalls. Firstly, TAS histopathology diagnosis can be difficult; second, the limited clinical experience with this condition can make its management complex. We conducted a detailed systematic review, focusing on the knowledge available regarding TAS etiopathogenesis, treatment options and prognosis. The aim is to present the main TAS characteristics and to summarize the clinical experiences described worldwide, in order to provide a useful clinical tool...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909826/preparation-and-characterization-of-tetrabromopyrrole-debrominase-from-marine-proteobacteria
#20
Jonathan R Chekan, Bradley S Moore
While halogenases have been studied for decades, the first natural product dehalogenase was only recently described. This bacterial enzyme, Bmp8, catalyzes the reductive debromination of 2,3,4,5-tetrabromopyrrole to form 2,3,4-tribromopyrrole as part of the biosynthesis of pentabromopseudilin, a marine natural product. Bmp8 is hypothesized to utilize a catalytic mechanism analogous to the important human thyroid hormone deiodinase enzyme family, potentially enabling Bmp8 to serve as model system to study this conserved mechanism...
2018: Methods in Enzymology
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