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Stage 2b colon cancer

Yuanyuan Lu, Xiaodi Zhao, Guanhong Luo, Gaofei Shen, Kai Li, Gui Ren, Yan Pan, Xin Wang, Daiming Fan
Our previous work identified thioredoxin-like protein 2 (Txl-2), a novel thioredoxin family member, as the target of the monoclonal antibody MC3 which can detect colon cancer with high sensitivity and specificity. In the present study, the function of the most abundant isoform Txl-2b in cell proliferation and apoptosis was investigated. Txl-2 overexpression correlated with increased clinical stages. Inhibition of Txl-2b suppressed cell proliferation, induced cell cycle arrest at the G1/S phase, and led to responsiveness to the vincristine-induced apoptosis in SW620 cells...
July 28, 2015: Cancer Letters
Ali Kocatas, Ahmet Cem Dural, Nurten Sever, Burak Kankaya, Mahmut Dogan, Gulcin Yegen, Murat Gonenc, Bilge M Bilgic, Mehmet Ali Bedirhan, Halil Alis
Granular cell tumour (GCT), which is a rare benign soft tissue neoplasm, is mostly found in the skin and soft tissue but may develop anywhere in the body. There are less than 10 reported cases of mediastinal GCTs in the current literature. Furthermore, colonic GCTs have recently gained attention due to the increased public awareness on the importance of colonoscopy screening. We report a case of a 52-year-old woman diagnosed incidentally with synchronous GCTs of the mediastinum and the hepatic flexure on her routine screening for post-operative follow-up for status-post right modified radical mastectomy due to a T2N1M0, Stage 2B breast cancer...
January 2014: Journal of Minimal Access Surgery
Yuanyuan Lu, Xiaodi Zhao, Kai Li, Guanhong Luo, Yongzhan Nie, Yongquan Shi, Yi Zhou, Gui Ren, Bin Feng, Zhenxiong Liu, Yan Pan, Ting Li, Xuegang Guo, Kaichun Wu, Antonio Miranda-Vizuete, Xin Wang, Daiming Fan
AIMS: Our previous work identified thioredoxin-like protein 2 (Txl-2) as the target of the monoclonal antibody MC3 associated with colon cancer, but its underlying mechanisms remain poorly understood. Txl-2, a novel thioredoxin (Trx) and nucleoside diphosphate kinase family member, is alternatively spliced and gives rise to three different Txl-2 isoforms. In this study, Txl-2 expression in colon cancer, differential functions for Txl-2 isoforms in cell invasion and metastasis, and the downstream signaling were investigated...
September 20, 2013: Antioxidants & Redox Signaling
Ziya Akbulut, Abdullah Erdem Canda, Muhammet Fuat Ozcan, Ali Fuat Atmaca, Ahmet Tunc Ozdemir, Mevlana Derya Balbay
PURPOSE: We report our initial experience with robot-assisted laparoscopic neurovascular bundle (NVB) sparing radical cystoprostatectomy (RALRC), bilateral extended lymph node dissection (BELND) with intracorporeal Studer pouch construction for invasive bladder cancer. PATIENTS AND METHODS: After initially performing >50 cases of robot-assisted laparoscopic radical prostatectomies (RALRP), between December 2009 and April 2010, we performed 12 RALRC procedures with BELND...
September 2011: Journal of Endourology
Luca Ansaloni, Roland E Andersson, Franco Bazzoli, Fausto Catena, Vincenzo Cennamo, Salomone Di Saverio, Lorenzo Fuccio, Hans Jeekel, Ari Leppäniemi, Ernest Moore, Antonio D Pinna, Michele Pisano, Alessandro Repici, Paul H Sugarbaker, Jean-Jaques Tuech
BACKGROUND: Obstructive left colon carcinoma (OLCC) is a challenging matter in terms of obstruction release as well of oncological issues. Several options are available and no guidelines are established. The paper aims to generate evidenced based recommendations on management of OLCC. METHODS: The PubMed and Cochrane Library databases were queried for publications focusing on OLCC published prior to April 2010. A extensive retrieval, analyses, and grading of the literature was undertaken...
December 28, 2010: World Journal of Emergency Surgery: WJES
Xiao-Bo Long, Guang-Bin Sun, Shuang Hu, Geng-Tian Liang, Nan Wang, Xin-Hao Zhang, Ping-Ping Cao, Hong-Tao Zhen, Yong-Hua Cui, Zheng Liu
MicroRNAs (miRNAs) are endogenously expressed non-coding RNAs, which are involved in the gene expression regulation. Lethal-7a (let-7a) is a founding member of miRNA family and recently it was found to be associated with several cancers, such as lung and colon cancers. In the present study, we found that let-7a miRNA expression was significantly downregulated both in human laryngeal squamous cancer tissues and in Hep-2 cells, a laryngeal cancer cell line, as compared with adjacent normal tissues and BEAS-2B cells, respectively...
November 2009: Oncology Reports
Mansoor Abdul, Shawntae D Mccray, Naseema M Hoosein
BACKGROUND: In prostate cancer, gamma-aminobutyric acid (GABA) has been previously reported to increase cellular proliferation via the ionotropic GABAa receptor (GABAar) and to promote cellular invasiveness via the metabotropic GABAb receptor. METHODS: In this study, we have investigated, by immunohistochemistry, GABAar levels in 12 normal human prostate, 13 benign prostatic hyperplasia (BPH) and 148 human prostate cancer specimens. We have also examined the effect of several GABA agonists and antagonists on the in vitro proliferation of four human prostate cancer cell lines: LNCaP, MDA-PCA-2b, DU145 and PC3...
2008: Acta Oncologica
Constantine Gennatas, Despoina Mouratidou, George Androulakis, Vasilios Georgoulias, Nikolaos Tsavaris, Michail Philippakis, Emmanouil Michailakis, Charalampos Kalofonos, Stavros Mpesmpeas, John Katsos, Miranda Tsitoura, George Retalis, Elias Mallas, Dionysios Voros, Charalampos Andreadis, George Hatzistylianos, Christos Pisiotis, Dimitrios Kamilarios, Sotirios Kakoliris, Vasilios Komporozos, Dimitrios Kannas, Nikolaos Legakis, Theodoros Mpatakis, John Ntamtsios, Evangelos Papaevangelou, George Peros, Alexis Photopoulos, Anastasia Pouli, Sotirios Prigouris, Lazaros Samanidis, Vasilios Sakellariou, Vasilios Smyrniotis, George Polymeneas, John Vasiliou, Athanasios Athanasiou, John Papadimitriou
AIMS AND BACKGROUND: Trials of adjuvant systemic therapy in high risk patients with Dukes' B2 and C colon cancer utilizing 5-fluorouracil-based regimens have been ongoing since the 1960s. The aim of this study was to compare the combination of 5-FU and leucovorin with the combination of 5-FU and alfa-2b interferon (IFN) in patients who had undergone "curative" resection foronocarcinoma. STUDY DESIGN: A total of 322 patients with histologically proven adenocarcinoma of the colon, Dukes' stage B2 and C, were entered in the study...
January 2002: Tumori
Akikuni Yagita, Syoji Maruyama, Shinji Wakasugi, Yasushi Sukegawa
IL-12 is considered to be one of the most important cytokines in anti-cancer therapy. We have demonstrated that substances derived from Basidiomycetes, such as active hexose-correlated compound (AHCC) and PSK induce the production of IL-12. In this study, the MHC dependency of IL-12 production induced by various mycelial extracts, PSK, AHCC and IL-X, was examined. During tumor-bearing, higher serum IL-12 levels were observed in H-2a and H-2b mice as compared to H-2d mice. Concerning the effect of genetic background of mice on response to mycelial extracts, AHCC administration enhanced the serum IL-12 level in H-2b mice but not in H-2d mice, while PSK administration increased the serum IL-12 level in H-2d mice but not in H-2b mice...
January 2002: In Vivo
Y K Choi, E Novembre
BACKGROUND AND OBJECTIVES: A 71-year-old woman was referred for control of intractable left-sided abdominal pain and constipation caused by stage 2B rectosigmoid colon cancer. She was treated with an intravenous morphine sulfate infusion at 4 mg/h which made her drowsy and lethargic. Because the distal colon is innervated by the inferior mesenteric sympathetic ganglion, it was hypothesized that a continuous block of this ganglion would provide both pain control and increased intestinal motility...
July 1999: Regional Anesthesia and Pain Medicine
D Reintgen, J Kirkwood
Interferon alfa-2b has recently been approved by the FDA as the first effective adjuvant therapy for the treatment of the "high risk for recurrence" melanoma patient. In a landmark study (ECOG 1684), the use of high dose Interferon alfa-2b for one year in melanoma patients with either deep primary melanomas or resected nodal metastases resulted in significant increases in overall survival (p = 0.04) and disease-free survival (p < 0.01) compared to the control, observation arm. If one considers only those patients with nodal metastases (89% of the study population) the survival benefit associated with adjuvant Interferon alfa-2b had a p value of 0...
March 1997: Journal of the Florida Medical Association
G Frasci, F Leone, M Monaco, L Cremone, U Sapio, F Faiella, A Espinosa, G Persico
PURPOSE: To determine whether interferon: alpha 2b can improve results of 5-fluorouracil adjuvant treatment of Dukes C colorectal cancer patients, we compared the outcome of patients receiving a fluorouracil-interferon combination to that of historic controls treated with fluorouracil alone. METHODS: Fifty-seven Dukes C colorectal cancer patients were given 5-fluorouracil-interferon-alpha 2b adjuvant treatment from October 1986 to September 1990. The results were compared with those obtained in 51 consecutive patients treated at the same institutions with 5-fluorouracil (5-FU) alone (used at the same doses and schedule) between 1983 and 1986...
July 1994: Diseases of the Colon and Rectum
H J Schmoll, C H Köhne-Wömpner, W Hiddemann, H Knipp, H Wilke, H Bodenstein, P Schöffski, C Bokemeyer, H P Lohrmann, J Preiss
We conducted a phase I/II trial of 5-fluorouracil (5-FU)/folinic acid (FA) and alpha-2b interferon (IFN) in 43 previously untreated patients with measurable metastatic colorectal cancer. Patients had disease progression prior to therapy consistent of 5-FU 500 mg/m2 (level A) or 600 mg/m2 (level B) as starting dose administered as a 2-hour infusion, FA 200 mg/m2, and alpha-2b IFN 5MU/m2 subcutaneously. All drugs were given on days 1 to 5 and cycles were repeated after 3 to 4 weeks. The aim of the study was to define the maximal tolerable dose (MTD) of 5-FU for this schedule...
April 1992: Seminars in Oncology
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