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https://www.readbyqxmd.com/read/29785233/therapeutic-outcome-of-intralesional-immunotherapy-in-cutaneous-warts-using-the-mumps-measles-and-rubella-vaccine-a-randomized-placebo-controlled-trial
#1
Guneet Awal, Simplepreet Kaur
Background: Various treatment modalities have been described in the literature for treating warts, but none thus far have demonstrated optimal results. Recently, the mumps, measles, and rubella (MMR) antigen has gained popularity because of its proven efficacy in the treatment of warts. Aim: The goal was to evaluate the efficacy and safety of intralesional MMR antigen in the treatment of cutaneous warts. Methods: Patients were divided into an MMR (study) group and a normal saline (control) group. Injections were administered into the single largest wart on each patient every two weeks...
May 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29784468/vaccines-and-the-risk-of-acute-disseminated-encephalomyelitis
#2
Yong Chen, Fubao Ma, Yuanling Xu, Xuhua Chu, Jinlin Zhang
BACKGROUND: It is important to examine the risk of Acute disseminated encephalomyelitis (ADEM) after vaccination. METHODS: We conducted a nested case-control study between January 2011 and December 2015. Four controls per case were matched for age, gender, address. An independent expert committee validated the diagnoses of cases and controls. Data on vaccinations were obtained from computerized vaccination records. The analyses were conducted with the use of conditional logistic regression...
May 18, 2018: Vaccine
https://www.readbyqxmd.com/read/29781436/concern-over-reported-number-of-measles-cases-in-yemen
#3
Xun Yuan
No abstract text is available yet for this article.
May 12, 2018: Lancet
https://www.readbyqxmd.com/read/29778514/conditional-admission-religious-exemption-type-and-nonmedical-vaccine-exemptions-in-california-before-and-after-a-state-policy-change
#4
Alison M Buttenheim, Malia Jones, Caitlin Mckown, Daniel Salmon, Saad B Omer
Recent measles and pertussis outbreaks in the US have focused national attention on state laws governing exemptions from mandatory vaccines for school entry. After several years of increases in nonmedical exemptions in California, the state assembly passed Assembly Bill 2109 in 2012, making nonmedical exemptions more difficult to obtain by requiring parents to obtain a signature from a health care provider. We used data from the California Department of Public Health to describe changes in the overall prevalence of personal belief exemptions and compositional changes in immunization status for the school years 2012-2013 through 2015-2016...
May 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29773050/the-importance-of-complying-with-vaccination-protocols-in-developed-countries-anti-vax-hysteria-and-the-spread-of-severe-preventable-diseases
#5
Franco Pandolfi, Laura Franza, Laura Todi, Valentina Carusi, Michele Centrone, Alessandro Bonomo, Estelle E Newton, Domenico Schiavino, Eleonora Nucera
BACKGROUND: Vaccines are very effective medical tools for disease prevention and life span increase. Controversies have raised concern about their safety, from autism to polio vaccine contamination with simian virus 40 (SV-40). Hysteria surrounding vaccine-associated risks has resulted in a declining number of vaccinations in developed countries. Outbreaks of vaccine-preventable diseases (e.g. measles) have occurred in Europe and North America, causing also some causalities. OBJECTIVES: In this review, data on safety and efficacy of vaccines are discussed, showing that the benefits of vaccines far outweigh the risks and that it is important to comply with vaccination protocols, to avoid spreading of severe, preventable diseases...
May 17, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29771601/response-to-third-rubella-vaccine-dose
#6
Lotta Siira, Hanne Nøkleby, Regine Barlinn, Øystein R Riise, Ingeborg S Aaberge, Susanne G Dudman
Limited data exist on the immunogenicity of a third dose of the measles, mumps, and rubella vaccine (MMR). In this study, our aim was to evaluate the long-term rubella immunogenicity afforded by two childhood MMR doses of the Norwegian vaccination program in a cohort of conscripts and to determine the effect of an additional dose of MMR vaccine, in order to inform vaccination policy. Blood samples from Norwegian conscripts (n = 495) taken both before and eight months after administration of a dose of MMR vaccine were tested using an enzyme immunoassay to measure anti-rubella IgG...
May 17, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29767404/carrier-cells-for-delivery-of-oncolytic-measles-virus-into-tumors-determinants-of-efficient-loading
#7
Chun Xu, Mao Xia, Gang Meng, Chunyan Li, Aiqin Jiang, Jiwu Wei
Oncolytic measles virus (OMV) is a promising antitumor agent. However, the presence of anti-measles neutralizing antibodies (NAbs) against the hemagglutinin (H) protein of OMV is a major barrier to the therapeutic application of OMV in clinical practice. In order to overcome this challenge, specific types of cells have been used as carriers for OMV. Differential loading strategies appear to result in different therapeutic outcomes; despite this, only few studies have reported practical ex vivo loading strategies required for effective treatment...
May 16, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29766840/rubella-infection-in-pregnancy-and-congenital-rubella-in-united-kingdom-2003-to-2016
#8
Antoaneta Bukasa, Helen Campbell, Kevin Brown, Helen Bedford, Mary Ramsay, Gayatri Amirthalingam, Pat Tookey
Rubella vaccination has been included in the United Kingdom's (UK) routine childhood schedule for nearly 30 years. The UK achieved World Health Organization (WHO) elimination status in 2016 and acute rubella infections are rare. In the period 2003-16, 31 rubella infections in pregnancy (0.23 per 100,000 pregnancies) were identified through routine surveillance, of which 26 were in women who were born abroad. Five of the 31 rubella infections led to congenital rubella syndrome in the infant and three had confirmed congenital rubella infection without congenital rubella syndrome...
May 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29764161/the-emerging-role-of-oncolytic-virus-therapy-against-cancer
#9
Luke Russell, Kah-Whye Peng
This review discusses current clinical advancements in oncolytic viral therapy, with a focus on the viral platforms approved for clinical use and highlights the benefits each platform provides. Three oncolytic viruses (OVs), an echovirus, an adenovirus, and a herpes simplex-1 virus, have passed governmental regulatory approval in Latvia, China, and the USA and EU. Numerous other recombinant viruses from diverse families are in clinical testing in cancer patients and we highlight the design features of selected examples, including adenovirus, herpes simplex virus, measles virus, retrovirus, reovirus, vaccinia virus, vesicular stomatitis virus...
April 2018: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29757401/viral-therapy-gets-personal-a-potential-gene-signature-to-predict-susceptibility-to-measles-virus-oncolysis
#10
Peter A Forsyth, Daniel Abate-Daga
No abstract text is available yet for this article.
May 10, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29757209/immunization-offer-targeting-migrants-policies-and-practices-in-italy
#11
Teresa Dalla Zuanna, Martina Del Manso, Cristina Giambi, Flavia Riccardo, Antonino Bella, Maria Grazia Caporali, Maria Grazia Dente, Silvia Declich
The unprecedented flow of migrants over the last three years places Italy in front of new issues regarding medical care from the rescue phase up to the integration into the national health services, including preventive actions. We used online questionnaires to investigate the Italian national and regional policies for immunization offer targeting asylum seekers, refugees, irregular migrants and unaccompanied minors. Another questionnaire was used to assess how these policies are translated into practice in migrant reception centres and community health services...
May 12, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29757123/the-role-of-humor-in-messaging-about-the-mmr-vaccine
#12
Emily Moyer-Gusé, Melissa J Robinson, Jessica Mcknight
Outbreaks of vaccine-preventable diseases have increased due, in part, to misconceptions about vaccine safety (Kennedy et al., 2011). Extant literature has examined various messages designed to correct false beliefs about vaccination risks and to urge parents to vaccinate their children. The present study is designed to contribute to this literature by drawing on the broader research and theory on resistance to persuasion and correcting false beliefs. We examine the effects of a humorous (vs. non-humorous) message about the importance of the measles, mumps, and rubella vaccine on parents' vaccine hesitancy...
May 14, 2018: Journal of Health Communication
https://www.readbyqxmd.com/read/29755760/impact-of-measles-supplementary-immunisation-activities-on-utilisation-of-maternal-and-child-health-services-in-low-income-and-middle-income-countries
#13
Iryna Postolovska, Stéphane Helleringer, Margaret E Kruk, Stéphane Verguet
Background: Measles supplementary immunisation activities (SIAs) are an integral component of measles elimination in low-income and middle-income countries (LMICs). Despite their success in increasing vaccination coverage, there are concerns about their negative consequences on routine services. Few studies have conducted quantitative assessments of SIA impact on utilisation of health services. Methods: We analysed the impact of SIAs on utilisation of selected maternal and child health services using Demographic and Health Surveys and Multiple Indicator Cluster Surveys from 28 LMICs, where at least one SIA occurred over 2000-2014...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29755710/laboratory-biomarkers-to-facilitate-differential-diagnosis-between-measles-and-kawasaki-disease-in-a-pediatric-emergency-room-a-retrospective-study
#14
Danilo Buonsenso, Giulia Macchiarulo, Maria Chiara Supino, Francesco La Penna, Simona Scateni, Alessandra Marchesi, Antonino Reale, Elena Boccuzzi
This retrospective study was conducted to analyze clinical and laboratoristic parameters to individuate specific differences and facilitate differential diagnosis between Measles and Kawasaki Disease (KD) at first evaluation in an emergency room. We found similar clinical features as duration of fever and number of KD criteria (p > 0.5) but significant differences in white blood cell count, neutrophils, CRP and LDH levels (p < 0.001). LDH value ≥ 800 mg/dl had sensibility of 89% and specificity of 90% for Measles while CRP ≥ 3 mg/dl had sensibility 89% and specificity of 85% for KD...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29752126/simultaneous-co-detection-of-wild-type-and-vaccine-strain-measles-virus-using-the-bd-max-system
#15
Kiran Thapa, Justin A Ellem, Kerri Basile, Ian Carter, Tom Olma, Sharon C-A Chen, Dominic E Dwyer, Jen Kok
Despite the reported elimination of measles virus in Australia, importation of cases from endemic countries continues to lead to secondary local transmission and outbreaks. Rapid laboratory confirmation of measles is paramount for individual patient management and outbreak responses. Further, it is important to rapidly distinguish infection from wild-type virus or vaccine strains to guide public health responses. We developed a high throughput, TaqMan-based multiplex reverse-transcription-polymerase chain reaction (PCR) assay using the BD MAX platform (Becton Dickinson) that simultaneously detects measles virus and differentiates between wild-type and vaccine strains without the need for sequencing...
May 8, 2018: Pathology
https://www.readbyqxmd.com/read/29751531/computational-analysis-of-the-interaction-energies-between-amino-acid-residues-of-the-measles-virus-hemagglutinin-and-its-receptors
#16
Fengqi Xu, Shigenori Tanaka, Hirofumi Watanabe, Yasuhiro Shimane, Misako Iwasawa, Kazue Ohishi, Tadashi Maruyama
Measles virus (MV) causes an acute and highly devastating contagious disease in humans. Employing the crystal structures of three human receptors, signaling lymphocyte-activation molecule (SLAM), CD46, and Nectin-4, in complex with the measles virus hemagglutinin (MVH), we elucidated computationally the details of binding energies between the amino acid residues of MVH and those of the receptors with an ab initio fragment molecular orbital (FMO) method. The calculated inter-fragment interaction energies (IFIEs) revealed a number of significantly interacting amino acid residues of MVH that played essential roles in binding to the receptors...
May 3, 2018: Viruses
https://www.readbyqxmd.com/read/29750140/proof-of-principle-that-a-decoy-virus-protects-oncolytic-measles-virus-against-neutralizing-antibodies
#17
Chun Xu, Annika Verena Goß, Carmen Dorneburg, Klaus-Michael Debatin, Jiwu Wei, Christian Beltinger
Background: Attenuated oncolytic measles virus (OMV) is a promising antitumor agent in early-phase clinical trials. However, pre-existing immunity against measles might be a hurdle for OMV therapy. Methods: OMV was inactivated with short-wavelength ultraviolet light (UV-C). Loss of replication and oncolytic activity of UV-inactivated OMV were confirmed by tissue culture infective dose 50 (TCID50 ) assay using Vero cells and by flow cytometry using Jurkat cells. An enzyme-linked immunosorbent assay was performed to verify that UV-inactivated OMV remained antigenic...
2018: Oncolytic Virotherapy
https://www.readbyqxmd.com/read/29743309/utility-of-a-stressed-snp-real-time-pcr-assay-for-the-rapid-identification-of-measles-vaccine-strain-in-patient-samples
#18
Thomas Tran, Renata Kostecki, Michael Catton, Julian Druce
Rapid differentiation of wild-type measles virus from measles vaccine strains is crucial during a measles outbreak and in a measles elimination setting. A real-time RT-PCR for the rapid detection of measles vaccine strains was developed with high specificity and greater sensitivity than when compared to traditional measles genotyping methods. The "stressed" minor grove binder TaqMan probe design approach achieves specificity to vaccine strains only, without compromising sensitivity. This assay has proven to be extremely useful in outbreak settings, without requiring sequence genotyping, for over 4 years at the Regional Measles Reference Laboratory for the Western Pacific Region...
May 9, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29743202/macrophages-and-dendritic-cells-are-the-predominant-cells-infected-in-measles-in-humans
#19
Ingrid V Allen, Stephen McQuaid, Rosana Penalva, Martin Ludlow, W Paul Duprex, Bertus K Rima
Characterization of human measles cases is essential in order to better assess the data generated in model systems of morbillivirus infection. To this end, we collected formalin-fixed tissue samples from 23 natural measles cases from different areas in the world and different phases of disease ranging from prodromal and acute measles to a persistent infection in an immunocompromised subject. We show that the vast majority of measles virus (MV)-infected cells in epithelia were intraepithelial immune cells that were, in most cases, positive for the CD11c myeloid cell marker...
June 27, 2018: MSphere
https://www.readbyqxmd.com/read/29741721/update-from-the-advisory-committee-on-immunization-practices
#20
Sean T O'Leary, David W Kimberlin, Yvonne A Maldonado
The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, each of whom is appointed to a 4-year term. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. The ACIP met on October 25 and 26, 2017, to discuss herpes zoster vaccine, the child/adolescent and adult vaccination schedules, Japanese encephalitis (JE) epidemiology and vaccines, pneumococcal vaccines, anthrax vaccines and disaster preparedness, hepatitis A outbreaks, influenza surveillance and vaccination coverage, vaccine safety, and considerations for a potential third dose of measles-mumps-rubella (MMR) vaccine to combat ongoing mumps outbreaks...
May 7, 2018: Journal of the Pediatric Infectious Diseases Society
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