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naringenin

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https://www.readbyqxmd.com/read/28077078/transcriptomic-evidence-for-the-control-of-soybean-root-isoflavonoid-content-by-regulation-of-overlapping-phenylpropanoid-pathways
#1
Mehran Dastmalchi, Patrick Chapman, Jaeju Yu, Ryan S Austin, Sangeeta Dhaubhadel
BACKGROUND: Isoflavonoids are a class of specialized metabolites found predominantly in legumes. They play a role in signaling for symbiosis with nitrogen-fixing bacteria and inhibiting pathogen infection. RESULTS: A transcriptomic approach using soybean cultivars with high (Conrad and AC Colombe) and low (AC Glengarry and Pagoda) root isoflavonoid content was used to find elements that underlie this variation. Two genes, encoding the flavonoid-metabolizing enzymes, flavonoid 3'-hydroxylase (GmF3'H) and dihydroflavonol 4-reductase (GmDFR), had lower expression levels in high isoflavonoid cultivars...
January 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28067270/osmyc2-an-essential-factor-for-ja-inductive-sakuranetin-production-in-rice-interacts-with-myc2-like-proteins-that-enhance-its-transactivation-ability
#2
Satoshi Ogawa, Koji Miyamoto, Keiichirou Nemoto, Tatsuya Sawasaki, Hisakazu Yamane, Hideaki Nojiri, Kazunori Okada
Biosynthesis of sakuranetin, a flavonoid anti-fungal phytoalexin that occurs in rice, is highly dependent on jasmonic acid (JA) signalling and induced by a variety of environmental stimuli. We previously identified OsNOMT, which encodes naringenin 7-O-methyltransferase (NOMT); NOMT is a key enzyme for sakuranetin production. Although OsNOMT expression is induced by JA treatment, the regulation mechanism that activates the biosynthetic pathway of sakuranetin has not yet been elucidated. In this study, we show that JA-inducible basic helix-loop-helix transcriptional factor OsMYC2 drastically enhances the activity of the OsNOMT promoter and is essential for JA-inducible sakuranetin production...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28065188/flavanone-rich-citrus-beverages-counteract-the-transient-decline-in-postprandial-endothelial-function-in-humans-a-randomised-controlled-double-masked-cross-over-intervention-study
#3
Catarina Rendeiro, Honglin Dong, Caroline Saunders, Laura Harkness, Melvin Blaze, Yanpeng Hou, Ronald L Belanger, Giulia Corona, Julie A Lovegrove, Jeremy P E Spencer
Specific flavonoid-rich foods/beverages are reported to exert positive effects on vascular function; however, data relating to effects in the postprandial state are limited. The present study investigated the postprandial, time-dependent (0-7 h) impact of citrus flavanone intake on vascular function. An acute, randomised, controlled, double-masked, cross-over intervention study was conducted by including middle-aged healthy men (30-65 years, n 28) to assess the impact of flavanone intake (orange juice: 128·9 mg; flavanone-rich orange juice: 272·1 mg; homogenised whole orange: 452·8 mg; isoenergetic control: 0 mg flavanones) on postprandial (double meal delivering a total of 81 g of fat) endothelial function...
January 9, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28058739/comparative-study-of-the-binding-of-3-flavonoids-to-the-fat-mass-and-obesity-associated-protein-by-spectroscopy-and-molecular-modeling
#4
Lijiao Zhang, Ting Ren, Zechun Wang, Ruiyong Wang, Junbiao Chang
This study aims to investigate the interaction between 3 flavonoids (quercetin, apigenin, and naringenin) and fat mass and obesity-associated protein by fluorescence, ultraviolet-visible absorption spectroscopy, and molecular modeling. Results indicate that the intrinsic fluorescence of fat mass and obesity-associated protein can be quenched by the 3 flavonoids through a static quenching procedure. Thermodynamic analysis and molecular modeling results suggest that hydrophobic interaction and hydrogen bond forces play the major roles in the binding process...
January 6, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28039793/lippia-graveolens-photochemopreventive-effect-against-uvb-radiation-induced-skin-carcinogenesis
#5
A M García-Bores, A M Espinosa-González, A Reyna-Campos, S Cruz-Toscano, J C Benítez-Flores, C T Hernández-Delgado, S Flores-Maya, M Urzúa-Meza, I Peñalosa-Castro, C L Céspedes-Acuña, J G Avila-Acevedo
Lippia graveolens HBK (Mexican oregano) is a species that is regularly used as a condiment in Mexican cuisine. In traditional medicine, it is used for the treatment of respiratory and digestive illnesses, headaches, rheumatism and inflammation-related disorders. The main chemical components reported in this species include the following: terpenoids, iridoids and flavonoids. The aim of this study was to determine the potential photochemopreventive effect of the methanolic extract of Lippia graveolens (MELG) against ultraviolet B (UVB)-induced skin cancer in SKH-1 mice...
December 18, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28032362/prioritizing-pharmacokinetic-drug-interaction-precipitants-in-natural-products-application-to-oatp-inhibitors-in-grapefruit-juice
#6
Emily J Johnson, Christina S Won, Kathleen Köeck, Mary F Paine
Natural products, including botanical dietary supplements and exotic drinks, represent an ever-increasing share of the health care market. The parallel ever-increasing popularity of self-medicating with natural products increases the likelihood of co-consumption with conventional drugs, raising concerns for unwanted natural product-drug interactions. Assessing the drug interaction liability of natural products is challenging due to the complex and variable chemical composition inherent to these products, necessitating a streamlined preclinical testing approach to prioritize precipitant individual constituents for further investigation...
December 29, 2016: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/28030851/naringenin-an-analgesic-and-anti-inflammatory-citrus-flavanone
#7
EDITORIAL
Marília F Manchope, Rubia Casagrande, Waldiceu A Verri
No abstract text is available yet for this article.
December 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/28028844/improved-tlc-bioautographic-assay-for-qualitative-and-quantitative-estimation-of-tyrosinase-inhibitors-in-natural-products
#8
Jinge Zhou, Qingjiu Tang, Tao Wu, Zhihong Cheng
INTRODUCTION: TLC bioautography for tyrosinase inhibitors has made recent progress; however, an assay with a relative low consumption of enzyme and quantitative capability would greatly advance the efficacy of related TLC bioautographic assays. OBJECTIVE: An improved TLC bioautographic assay for detecting tyrosinase inhibitors was developed and validated in this study. METHODS: L-DOPA (better water-solubility than L-tyrosine) was used as the substrate instead of reported L-tyrosine...
December 28, 2016: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28025998/in-vitro-screening-of-radioprotective-properties-in-the-novel-glucosylated-flavonoids
#9
Hao Yu, Jeremy S Haskins, Cathy Su, Allison Allum, Alexis H Haskins, Victoria A Salinas, Shigeaki Sunada, Taisuke Inoue, Yasushi Aizawa, Mitsuru Uesaka, Takamitsu A Kato
Novel glucosyl flavonoids are developed by the addition of glucose to naturally occurring flavonoids. Flavonoids are known antioxidants that possess radioprotective properties. In order to investigate the radioprotective properties of novel glucosyl flavonoids, in vitro DNA double-strand breaks (DSBs) analysis was carried out. In the present study, Quercetin, Naringenin, and Hesperetin groups of flavonoids included in the natural and novel glucosyl 13 flavonoids were investigated. Flavonoids were mixed with Lambda DNA, and subsequently exposed to gamma‑rays...
November 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28004841/the-citrus-flavonoid-naringenin-confers-protection-in-a-murine-endotoxaemia-model-through-ampk-atf3-dependent-negative-regulation-of-the-tlr4-signalling-pathway
#10
Xin Liu, Ning Wang, Shijun Fan, Xinchuan Zheng, Yongjun Yang, Yuanfeng Zhu, Yongling Lu, Qian Chen, Hong Zhou, Jiang Zheng
Excessive activation of the TLR4 signalling pathway is critical for inflammation-associated disorders, while negative regulators play key roles in restraining TLR4 from over-activation. Naringenin is a citrus flavonoid with remarkable anti-inflammatory activity, but the mechanisms underlying its inhibition of LPS/TLR4 signalling are less clear. This study investigated the molecular targets and therapeutic effects of naringenin in vitro and in vivo. In LPS-stimulated murine macrophages, naringenin suppressed the expression of TNF-α, IL-6, TLR4, inducible NO synthase (iNOS), cyclo-oxygenase-2 (COX2) and NADPH oxidase-2 (NOX2)...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27988309/naringenin-suppresses-edwardsiella-tarda-infection-in-gaks-cells-by-nana-sialidase-inhibition
#11
Sayaka Shinyoshi, Yuko Kamada, Koki Matsusaki, Petros Kingstone Chigwechokha, Supawan Tepparin, Kyosuke Araki, Masaharu Komatsu, Kazuhiro Shiozaki
Edwardsiella tarda (E. tarda) is a gram-negative bacterium, which causes Edwardsiellosis in aquaculture. Previous studies indicate that E. tarda NanA sialidase plays crucial roles in infection through the desialylation of glycoproteins in fish cells. On the other hand, 2-deoxy-2,3-dehydro-N-acetylneuraminic acid, classic sialidase inhibitor, negatively regulates E. tarda infection of goldfish scale GAKS cells. Here, to development the suppression model of E. tarda infection for aquaculture application, the possibility of NanA inhibitory activities in citrus phytochemicals was evaluated as citrus extracts have widely been used as a supplement in fish diets for the improvement of meat quality...
December 14, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27988077/alternating-isocratic-and-step-gradient-elution-high-speed-counter-current-chromatography-for-the-isolation-of-minor-phenolics-from-ormocarpum-kirkii-bark
#12
Eutrophe Le Doux Kamto, Tatiane S C Carvalho, Joséphine Ngo Mbing, Marie C N Matene, Dieudonné E Pegnyemb, Gilda G Leitão
A total of 14 compounds were isolated from the ethanol bark extract of O. kirkii S. Moore (Fabaceae) by alternating isocratic and step gradient elution high-speed counter-current chromatography (HSCCC) methods, using several solvent systems with reference to the polarity of compounds being purified. The extract was successively fractionated with generic solvent systems including n-hexane-ethanol-water (4:2:2) and ethyl acetate-water (1:1). Resulting fractions were further purified using the following preparative gradient elution consisting of ethyl acetate-n-butanol-water (X:Y:10), (X:Y=9:1 (I); 8:2 (II); 7:3 (III); 6:4 (IV); 5:5 (V); 4:6 (VI) 3:7 (VII) and n-hexane- ethyl acetate-methanol-water (1:X:1:1), X=1, 2, 2...
January 13, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27974267/phytoestrogens-and-sterols-in-waters-with-cyanobacterial-blooms-%C3%A2-analytical-methods-and-estrogenic-potencies
#13
Tereza Procházková, Eliška Sychrová, Barbora Javůrková, Jaroslava Večerková, Jiří Kohoutek, Olga Lepšová-Skácelová, Luděk Bláha, Klára Hilscherová
Compounds with estrogenic potencies and their adverse effects in surface waters have received much attention. Both anthropogenic and natural compounds contribute to overall estrogenic activity in freshwaters. Recently, estrogenic potencies were also found to be associated with cyanobacteria and their blooms in surface waters. The present study developed and compared the solid phase extraction and LC-MS/MS analytical approaches for determination of phytoestrogens (8 flavonoids - biochanin A, coumestrol, daidzein, equol, formononetin, genistein, naringenin, apigenin - and 5 sterols - ergosterol, β-sitosterol, stigmasterol, campesterol, brassicasterol) and cholesterol in water...
March 2017: Chemosphere
https://www.readbyqxmd.com/read/27960283/metabolism-of-quercetin-and-naringenin-by-food-grade-fungal-inoculum-rhizopus-azygosporus-yuan-et-jong-atcc-48108
#14
Gerard Bryan Gonzales, Guy Smagghe, Jens Wittevrongel, Nguyen Thai Huynh, John Van Camp, Katleen Raes
Rhizopus azygosporus Yuan et Jong (ATCC 48108), a starter culture for fermented soybean tempeh, produces β-glucosidases that cleave flavonoid glycosides into aglycones during fermentation. However, recent data suggest that fermentation of a flavonoid glycoside-rich extract with this strain did not result in the production of aglycones. Thus, in this paper, flavonoid metabolism of this strain was investigated. Incubation of flavonoid aglycones, naringenin and quercetin, with R. azygosporus resulted in the production of flavonoid glucosyl-, hydroxyl-, and sulfo-conjugated derivatives...
December 14, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27956801/naringenin-protects-against-isoniazid-and-rifampicin-induced-apoptosis-in-hepatic-injury
#15
Chao Wang, Rui-Qin Fan, Yan-Xiang Zhang, Hao Nie, Kan Li
AIM: To explore the protective effects and mechanisms of naringenin (NRG) on hepatic injury induced by isoniazid (INH) and rifampicin (RIF). METHODS: Male mice were randomly divided into four groups and treated for 14 d as follows: normal control group was administered intragastrically with normal saline solution alone; model group was administered intragastrically with INH (100 mg/kg) and RIF (100 mg/kg); low- and high-dosage NRG pretreatment groups were administered intragastrically with different doses of NRG (50 or 100 mg/kg) 2 h before INH and RIF challenge...
November 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27941619/black-crowberry-empetrum-nigrum-l-flavonoids-and-their-health-promoting-activity
#16
REVIEW
Tunde Jurikova, Jiri Mlcek, Sona Skrovankova, Stefan Balla, Jiri Sochor, Mojmir Baron, Daniela Sumczynski
Nowadays, much research attention is focused on underutilized berry crops due to the high antioxidant activity of fruits. Black crowberry (Empetrum nigrum L.) represents an important source of flavonols (quercetin, rutin, myricetin, naringenin, naringin, morin, and kaempferol) and anthocyanins. The fruit components could be utilised as natural colourants or as a part of functional foods and, because of the high antioxidant activity, the berries of black crowberry can be used in the treatment of diseases accompanied with inflammation, or as an effective antibacterial and antifungal remedy...
December 7, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27933900/-13-c-nmr-and-lc-ms-profiling-of-stilbenes-from-elicited-grapevine-hairy-root-cultures
#17
Leo-Paul Tisserant, Jane Hubert, Michelle Lequart, Nicolas Borie, Nicolas Maurin, Serge Pilard, Philippe Jeandet, Aziz Aziz, Jean-Hugues Renault, Jean-Marc Nuzillard, Christophe Clément, Michèle Boitel-Conti, Eric Courot
Resveratrol and related oligostilbenes are defense molecules produced by grapevine in response to stresses including various elicitors or signal molecules. Together with their prominent role in planta, these compounds have been the center of much attention in recent decades due to their pharmacological properties. The cost-effective production of resveratrol derivatives such as viniferins or more structurally complex stilbene oligomers remains a challenging task. In this study, the chemical diversity of stilbenes produced by Vitis vinifera Pinot Noir hairy roots was investigated after elicitation for 4 days with a mixture of methyl jasmonate (100 μM) and cyclodextrins (50 mM)...
November 23, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/27933871/food-polyphenol-apigenin-inhibits-the-cytochrome-p450-monoxygenase-branch-of-the-arachidonic-acid-cascade
#18
Maryvonne Steuck, Stefan Hellhake, Nils Helge Schebb
The product of cytochrome P450 monooxygenase (P450) ω-hydroxylation of arachidonic acid (AA), 20- hydroxyeicosatetraenoic acid (HETE), is a potent vasoconstrictor. Utilizing microsomes as well as individual CYP4 isoforms we demonstrate here that flavonoids can block 20-HETE formation. Apigenin inhibits CYP4F2 with an IC50 value of 4.6 μM and 20-HETE formation in human liver and kidney microsomes at 2.4-9.8 μM. Interestingly, the structurally similar naringenin shows no relevant effect on the formation of 20-HETE...
November 30, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27916965/pathway-analysis-and-metabolites-identification-by-metabolomics-of-etiolation-substrate-from-fresh-cut-chinese-water-chestnut-eleocharis-tuberosa
#19
Yi-Xiao Li, Yong-Gui Pan, Feng-Ping He, Meng-Qi Yuan, Shang-Bin Li
Fresh-cut Chinese water chestnuts (CWC) turn yellow after being peeled, reducing their shelf life and commercial value. Metabolomics, the systematic study of the full complement of small molecular metabolites, was useful for clarifying the mechanism of fresh-cut CWC etiolation and developing methods to inhibit yellowing. In this study, metabolic alterations associated with etiolation at different growth stages (0 day, 2 days, 3 days, 4 days, 5 days) from fresh-cut CWC were investigated using LC-MS and analyzed by pattern recognition methods (principal component analysis (PCA), partial least squares-discriminant analysis (PLS-DA), and orthogonal projection to latent structures-discriminant analysis (OPLS-DA))...
December 1, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27915399/naringenin-interferes-with-the-anti-diabetic-actions-of-pioglitazone-via-pharmacodynamic-interactions
#20
Hiroki Yoshida, Rika Tsuhako, Toshiyuki Atsumi, Keiko Narumi, Wataru Watanabe, Chihiro Sugita, Masahiko Kurokawa
Pioglitazone is a peroxisome proliferator-activated receptor gamma (PPARγ) full agonist and useful for the treatment of type 2 diabetes mellitus. Naringenin is a citrus flavonoid with anti-inflammatory actions, which has been shown to prevent obesity-related diseases and to activate PPARγ. The aim of this study was to investigate whether dietary naringenin affects the actions of pioglitazone. We administered naringenin (100 mg/kg) and pioglitazone (10 mg/kg) to Tsumura Suzuki Obese Diabetes (TSOD) mice for 4 weeks and then conducted an oral glucose tolerance test...
December 3, 2016: Journal of Natural Medicines
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