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https://www.readbyqxmd.com/read/28223131/constituent-analysis-of-the-ethanol-extracts-of-chimonanthus-nitens-oliv-leaves-and-their-inhibitory-effect-on-%C3%AE-glucosidase-activity
#1
Hui Chen, Kehui Ouyang, Yan Jiang, Zhanwei Yang, Wenbing Hu, Lei Xiong, Ning Wang, Xin Liu, Wenjun Wang
The ethanol extracts of Chimonanthus nitens Oliv. leaves were prepared sequentially by ethanol gradient elution and tested for their α-glucosidase inhibitory. The fraction of 50% ethanol eluate (EE) exhibited the notable inhibition with IC50 of 0.376mg/mL. Also, 50% EE was chemically characterized by liquid chromatography-mass spectrometry (LC-MS) analysis. Eight compounds including rutin (1), hyperin (2), isoquercitrin (3), luteoloside (4), astragalin (6), quercetin (13), naringenin (14), kaempferol (15) were identified by compared with standard substances as well as proper luteolin-5-O-glucoside (5), kaempferol-7-O-rhamnoside (9), 5,7,8-trihydroxy-2-methoxyl-flavone-7-O-glucoside (10), kaempferol-7-O-acetyl-galactoside (11)...
February 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28220704/functional-characterization-of-a-new-tea-camellia-sinensis-flavonoid-glycosyltransferase
#2
Xianqian Zhao, Peiqiang Wang, Mingzhuo Li, Yeru Wang, Xiaolan Jiang, Lilan Cui, Yumei Qian, Juhua Zhuang, Liping Gao, Tao Xia
Tea (Camellia sinensis) is an important commercial crop, in which the high content of flavonoids provides the health benefits. A flavonoid glycosyltransferase (CsUGT73A20), belonged to Cluster IIIa was isolated from tea plant. The recombinant CsUGT73A20 in E. coli exhibited a broad substrate tolerance towards multiple flavonoids. Among them, kaempferol was the optimal substrate compared to quercetin, myricetin, naringenin, apigenin and kaempferide. However, no product was detected when UDP-galactose was used as the sugar donor...
February 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28216368/in-vitro-and-in-vivo-cysticidal-activity-of-extracts-and-isolated-flavanone-from-the-bark-of-prunus-serotina-a-bio-guided-study
#3
Francisca Palomares-Alonso, Irma Susana Rojas-Tomé, Guadalupe Palencia Hernández, María Adelina Jiménez-Arellanes, Martha Lydia Macías-Rubalcava, Angélica González-Maciel, Andrea Ramos-Morales, Rosalba Santiago-Reyes, Nelly Castro, Iliana González-Hernández, Yadira Rufino-González, Helgi Jung-Cook
Currently, neurocysticercosis treatment involves two drugs: albendazole and praziquantel; however, their efficacy is suboptimal and new cysticidal drugs are needed. The present paper reports the cysticidal activity of extracts of the bark from Prunus serotina against Taenia crassiceps cysts and the isolation and identification of the main components of the most active extract. Results showed that all extracts displayed in vitro cysticidal activity (EC50=17.9-88.5μg/mL), being the methanolic the most active and selective...
February 16, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28202192/ordered-mesoporous-silica-functionalized-with-%C3%AE-cyclodextrin-derivative-for-stereoisomer-separation-of-flavanones-and-flavanone-glycosides-by-nano-liquid-chromatography-and-capillary-electrochromatography
#4
Mariana Silva, Damián Pérez-Quintanilla, Sonia Morante-Zarcero, Isabel Sierra, María Luisa Marina, Zeineb Aturki, Salvatore Fanali
In this paper a chiral stationary phase (CSP) was prepared by the immobilization of a β-CD derivative (3,5-dimethylphenylcarbamoylated β-CD) onto the surface of amino-functionalized spherical ordered mesoporous silica (denoted as SM) via a urea linkage using the Staudinger reaction. The CSP was packed into fused silica capillaries 100μm I.D. and evaluated by means of nano-liquid chromatography (nano-LC) and capillary electrochromatography (CEC) using model compounds for the enantio- and the diastereomeric separation...
February 9, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28202103/deterrent-activity-of-hops-flavonoids-and-their-derivatives-against-stored-product-pests
#5
J Jackowski, J Popłoński, K Twardowska, J Magiera-Dulewicz, M Hurej, E Huszcza
Five flavonoids from hops, two of their derivatives, along with naringenin used as a model compound, were tested for their antifeedant activity against three coleopteran stored product pests: Sitophilus granarius L., Tribolium confusum Duv. and Trogoderma granarium Everts. The introduction, into the tested flavonoid molecules, of additional structural fragments such as prenyl or dimethylpyran moiety, is proposed to significantly alter the deterrent activity of the compounds. The prenyl moiety in flavonoids increased the deterrent activity of these compounds in all three of the grain feeding species used in the tests...
February 16, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28192136/inhibition-of-glycation-and-aldose-reductase-activity-using-dietary-flavonoids-a-lens-organ-culture-studies
#6
Kapil K Patil, Rajesh N Gacche
On the eve of increasing incidence of diabetes mellitus and related complications, the search for novel, safe and alternatives therapeutic approaches are evolving. In the present investigation, a panel of ten dietary flavonoids such as 4'-methoxyflavanone, formononetin, hesperetin, hesperidin, naringenin, naringin, rutin, diadzin, silibinin and silymarin was evaluated as possible inhibitors of sugar induced cataractogenesis using bovine lens organ culture studies. The effect of selected flavonoids was observed on glycation induced lens opacity, AGE fluorescence, carbonyl group formation (a biomarker of glycation), protein aggregation and aldose reductase (AR) inhibition...
February 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28185989/enhanced-oral-bioavailability-of-docetaxel-in-rats-combined-with-myricetin-in-situ-and-in-vivo-evidences
#7
Tianyun Hao, Yunni Ling, Meijuan Wu, Yajing Shen, Yu Gao, Shujun Liang, Yuan Gao, Shuai Qian
The purpose of this study was to investigate the effect of myricetin on the pharmacokinetics of docetaxel in rats. In comparison to oral docetaxel alone (40mg/kg), the bioavailability of docetaxel could be significantly enhanced by 1.6-2.4-fold via oral co-administration with various flavonoids (apigenin, naringenin, baicalein, quercetin and myricetin) at a dosage of 10mg/kg, and myricetin showed the highest bioavailability improvement. Further pharmacokinetic studies demonstrated that the presence of myricetin (5-20mg/kg) enhanced both Cmax and AUC of docetaxel with the highest Cmax (162ng/mL, 2...
February 7, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28179021/switch-a-dynamic-crispr-tool-for-genome-engineering-and-metabolic-pathway-control-for-cell-factory-construction-in-saccharomyces-cerevisiae
#8
Katherina García Vanegas, Beata Joanna Lehka, Uffe Hasbro Mortensen
BACKGROUND: The yeast Saccharomyces cerevisiae is increasingly used as a cell factory. However, cell factory construction time is a major obstacle towards using yeast for bio-production. Hence, tools to speed up cell factory construction are desirable. RESULTS: In this study, we have developed a new Cas9/dCas9 based system, SWITCH, which allows Saccharomyces cerevisiae strains to iteratively alternate between a genetic engineering state and a pathway control state...
February 8, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28157234/the-citrus-flavanone-naringenin-impairs-dengue-virus-replication-in-human-cells
#9
Sandra Frabasile, Andrea Cristine Koishi, Diogo Kuczera, Guilherme Ferreira Silveira, Waldiceu Aparecido Verri, Claudia Nunes Duarte Dos Santos, Juliano Bordignon
Dengue is one of the most significant health problems in tropical and sub-tropical regions throughout the world. Nearly 390 million cases are reported each year. Although a vaccine was recently approved in certain countries, an anti-dengue virus drug is still needed. Fruits and vegetables may be sources of compounds with medicinal properties, such as flavonoids. This study demonstrates the anti-dengue virus activity of the citrus flavanone naringenin, a class of flavonoid. Naringenin prevented infection with four dengue virus serotypes in Huh7...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28152668/evaluation-of-the-antioxidant-activity-of-betula-pendula-leaves-extract-and-its-effects-on-model-foods
#10
Nurul Aini Mohd Azman, Monika Skowyra, Kwestan Muhammad, María Gabriela Gallego, Maria Pilar Almajano
CONTEXT: Betula pendula Roth (Betulaceae) exhibits many pharmacological activities in humans including anticancer, antibacterial, and antiviral effects. However, the antioxidant activity of BP towards lipid degradation has not been fully determined. OBJECTIVE: The BP ethanol and methanol extracts were evaluated to determine antioxidant activity by an in vitro method and lyophilized extract of BP was added to beef patties to study oxidative stability. MATERIALS AND METHODS: Antioxidant activities of extracts of BP were determined by measuring scavenging radical activity against methoxy radical generated by Fenton reaction 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid (TEAC) radical cation, the oxygen radical absorbance capacity (ORAC) and the ferric reducing antioxidant power (FRAP) assays...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28148962/quercetin-inhibits-inflammasome-activation-by-interfering-with-asc-oligomerization-and-prevents-interleukin-1-mediated-mouse-vasculitis
#11
Talita P Domiciano, Daiko Wakita, Heather D Jones, Timothy R Crother, Waldiceu A Verri, Moshe Arditi, Kenichi Shimada
Interleukin-1β (IL-1β) is a highly inflammatory cytokine that significantly contributes to both acute and chronic inflammatory diseases. The secretion of IL-1β requires a unique protease, caspase-1, which is activated by various protein platforms called inflammasomes. Data suggests a key role for mitochondrial reactive oxygen species for inflammasome activation. Flavonoids constitute a group of naturally occurring polyphenolic molecules with many biological activities, including antioxidant effects. In this study, we investigated the effect of three flavonoids, quercetin (QUC), naringenin, and silymarim on inflammasome activation...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28143765/functional-expression-of-plant-derived-o-methyltransferase-flavanone-3-hydroxylase-and-flavonol-synthase-in-corynebacterium-glutamicum-for-production-of-pterostilbene-kaempferol-and-quercetin
#12
Nicolai Kallscheuer, Michael Vogt, Michael Bott, Jan Marienhagen
Plant polyphenols receive significant attention due to their anti-oxidative and health-promoting properties, and several microorganisms are currently engineered towards producing these valuable compounds. Previously, Corynebacterium glutamicum has been engineered for synthesizing polyphenol core structures such as the stilbene resveratrol and the (2S)-flavanone naringenin. Decoration of these compounds by O-methylation or hydroxylation would provide access to polyphenols of even higher commercial interest. In this study, introduction of a heterologous O-methyltransferase into a resveratrol-producing C...
January 28, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28111248/improving-key-enzyme-activity-in-phenylpropanoid-pathway-with-a-designed-biosensor
#13
Dandan Xiong, Shikun Lu, Jieyuan Wu, Chaoning Liang, Wei Wang, Wenzhao Wang, Jian-Ming Jin, Shuang-Yan Tang
Overexpressing key enzymes of biosynthetic pathways for overproduction of value-added products usually imposes metabolic burdens on cells, which can be circumvented by improving the key enzyme activities. p-Coumarate: CoA ligase (4CL) is a critical enzyme in the phenylpropanoid pathway that synthesizes various natural products. To screen for 4CL with improved activity, a biosensor of resveratrol whose biosynthetic pathway involves 4CL was designed by engineering the TtgR regulatory protein. The biosensor exhibited good specificity and robustness, allowing rapid and sensitive selection of resveratrol hyper-producers...
January 19, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28110221/simultaneous-determination-of-eight-flavonoids-in-plasma-using-lc-ms-ms-and-application-to-a-pharmacokinetic-study-after-oral-administration-of-pollen-typhae-extract-to-rats
#14
Xie-An Yu, John Teye Azietaku, Jin Li, Jun Cao, Mingrui An, Jun He, Xiu-Mei Gao, Yan-Xu Chang
A sensitive, reliable and validated LC-MS/MS method was developed to determine the presence of eight flavonoids (catechin, typhaneoside, isorhamnetin-3-O-neohesperidoside, astragalin, isorhamnetin-3-O-β-d-glucoside, naringenin, kaempferol and isorhamnetin) in rat plasma. Puerarin was selected as the internal standard. Precipitation of the protein method with acetonitrile was used to extract these flavonoids from the rat plasma samples. The analysis was carried out on an Eclipse plus C18 column (4.6 mm×100mm, 1...
January 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28107941/mil-101-cr-as-matrix-for-sensitive-detection-of-quercetin-by-matrix-assisted-laser-desorption-ionization-mass-spectrometry
#15
Guobin Han, Qiaoling Zeng, Zhongwei Jiang, Tiantian Xing, Chengzhi Huang, Yuanfang Li
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) has been proven as a useful and advanced technique in the identification of polymers and proteins. However, MALDI-TOF-MS still has the unavoidable drawback of self-signal interference with traditional organic matrices, which could suppress and overlap with the analyte signals in the low-mass region. In this work, MIL-101(Cr), a kind of metal-organic frameworks which possess high molecular weight, π-conjugated 3-D structure, coordinately unsaturated chromium sites (CUS) and strong absorption in the UV range, was employed to replace traditional organic matrices, and it was found that MIL-101(Cr) can dramatically eliminate the background peaks, showing high signal-to-noise level in the analysis of small molecules...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28077078/transcriptomic-evidence-for-the-control-of-soybean-root-isoflavonoid-content-by-regulation-of-overlapping-phenylpropanoid-pathways
#16
Mehran Dastmalchi, Patrick Chapman, Jaeju Yu, Ryan S Austin, Sangeeta Dhaubhadel
BACKGROUND: Isoflavonoids are a class of specialized metabolites found predominantly in legumes. They play a role in signaling for symbiosis with nitrogen-fixing bacteria and inhibiting pathogen infection. RESULTS: A transcriptomic approach using soybean cultivars with high (Conrad and AC Colombe) and low (AC Glengarry and Pagoda) root isoflavonoid content was used to find elements that underlie this variation. Two genes, encoding the flavonoid-metabolizing enzymes, flavonoid 3'-hydroxylase (GmF3'H) and dihydroflavonol 4-reductase (GmDFR), had lower expression levels in high isoflavonoid cultivars...
January 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28067270/osmyc2-an-essential-factor-for-ja-inductive-sakuranetin-production-in-rice-interacts-with-myc2-like-proteins-that-enhance-its-transactivation-ability
#17
Satoshi Ogawa, Koji Miyamoto, Keiichirou Nemoto, Tatsuya Sawasaki, Hisakazu Yamane, Hideaki Nojiri, Kazunori Okada
Biosynthesis of sakuranetin, a flavonoid anti-fungal phytoalexin that occurs in rice, is highly dependent on jasmonic acid (JA) signalling and induced by a variety of environmental stimuli. We previously identified OsNOMT, which encodes naringenin 7-O-methyltransferase (NOMT); NOMT is a key enzyme for sakuranetin production. Although OsNOMT expression is induced by JA treatment, the regulation mechanism that activates the biosynthetic pathway of sakuranetin has not yet been elucidated. In this study, we show that JA-inducible basic helix-loop-helix transcriptional factor OsMYC2 drastically enhances the activity of the OsNOMT promoter and is essential for JA-inducible sakuranetin production...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28065188/flavanone-rich-citrus-beverages-counteract-the-transient-decline-in-postprandial-endothelial-function-in-humans-a-randomised-controlled-double-masked-cross-over-intervention-study
#18
Catarina Rendeiro, Honglin Dong, Caroline Saunders, Laura Harkness, Melvin Blaze, Yanpeng Hou, Ronald L Belanger, Giulia Corona, Julie A Lovegrove, Jeremy P E Spencer
Specific flavonoid-rich foods/beverages are reported to exert positive effects on vascular function; however, data relating to effects in the postprandial state are limited. The present study investigated the postprandial, time-dependent (0-7 h) impact of citrus flavanone intake on vascular function. An acute, randomised, controlled, double-masked, cross-over intervention study was conducted by including middle-aged healthy men (30-65 years, n 28) to assess the impact of flavanone intake (orange juice: 128·9 mg; flavanone-rich orange juice: 272·1 mg; homogenised whole orange: 452·8 mg; isoenergetic control: 0 mg flavanones) on postprandial (double meal delivering a total of 81 g of fat) endothelial function...
December 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/28058739/comparative-study-of-the-binding-of-3-flavonoids-to-the-fat-mass-and-obesity-associated-protein-by-spectroscopy-and-molecular-modeling
#19
Lijiao Zhang, Ting Ren, Zechun Wang, Ruiyong Wang, Junbiao Chang
This study aims to investigate the interaction between 3 flavonoids (quercetin, apigenin, and naringenin) and fat mass and obesity-associated protein by fluorescence, ultraviolet-visible absorption spectroscopy, and molecular modeling. Results indicate that the intrinsic fluorescence of fat mass and obesity-associated protein can be quenched by the 3 flavonoids through a static quenching procedure. Thermodynamic analysis and molecular modeling results suggest that hydrophobic interaction and hydrogen bond forces play the major roles in the binding process...
January 6, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28039793/lippia-graveolens-photochemopreventive-effect-against-uvb-radiation-induced-skin-carcinogenesis
#20
A M García-Bores, A M Espinosa-González, A Reyna-Campos, S Cruz-Toscano, J C Benítez-Flores, C T Hernández-Delgado, S Flores-Maya, M Urzúa-Meza, I Peñalosa-Castro, C L Céspedes-Acuña, J G Avila-Acevedo
Lippia graveolens HBK (Mexican oregano) is a species that is regularly used as a condiment in Mexican cuisine. In traditional medicine, it is used for the treatment of respiratory and digestive illnesses, headaches, rheumatism and inflammation-related disorders. The main chemical components reported in this species include the following: terpenoids, iridoids and flavonoids. The aim of this study was to determine the potential photochemopreventive effect of the methanolic extract of Lippia graveolens (MELG) against ultraviolet B (UVB)-induced skin cancer in SKH-1 mice...
December 18, 2016: Journal of Photochemistry and Photobiology. B, Biology
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