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https://www.readbyqxmd.com/read/28636787/a-co-drug-conjugate-of-naringenin-and-lipoic-acid-mediates-neuroprotection-in-a-rat-model-of-oxidative-stress
#1
Tarek M Saleh, Monique C Saleh, Barry J Connell, Yang-Heon Song
Using our in vitro and in vivo models of oxidative stress, the current study was designed to determine the neuroprotective potential of naringenin, alone or in combination with lipoic acid. In our mixed neuronal culture exposed to hypoxia and subsequent reoxygenation, naringenin was shown to provide significant neuroprotection against cell death at a concentration of 2.5 μM. Lipoic acid (LA) did not produce neuroprotection at any concentration tested (0.25 to 100 μM). In contrast, when naringenin was covalently combined with LA, producing a novel compound named "VANL-100", significant neuroprotection was observed at a concentration as low as 2 x 10(-2) μM (100-fold more potent)...
June 21, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28634125/metabolic-engineering-of-yeast-for-fermentative-production-of-flavonoids
#2
Angelica Rodriguez, Tomas Strucko, Steen Gustav Stahlhut, Mette Kristensen, Daniel Killerup Svenssen, Jochen Forster, Jens Nielsen, Irina Borodina
Yeast Saccharomyces cerevisiae was engineered for de novo production of six different flavonoids (naringenin, liquiritigenin, kaempferol, resokaempferol, quercetin, and fisetin) directly from glucose, without supplementation of expensive intermediates. This required reconstruction of long biosynthetic pathways, comprising up to eight heterologous genes from plants. The obtained titers of kaempferol 26.57±2.66mgL(-1) and quercetin 20.38±2.57mgL(-1) exceed the previously reported titers in yeast. This is also the first report of de novo biosynthesis of resokaempferol and fisetin in yeast...
June 12, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28624598/inhibition-of-lps-induced-pro-inflammatory-responses-in-raw-264-7-macrophage-cells-by-pvp-coated-naringenin-nanoparticle-via-down-regulation-of-nf-%C3%AE%C2%BAb-p38mapk-mediated-stress-signaling
#3
Pradeep Kumar R, Annie Abraham
BACKGROUND: Naringenin (NAR) was found to display strong pharmacological properties. Since the clinical relevance of NAR is limited by its low bioavailability, we effectively synthesized and characterized a novel PVP-coated NAR nanoparticle (NAR NP) to enhance the therapeutic efficacy of NAR. The present study was designed to investigate the effects of NAR NP on lipopolysaccharide (LPS) induced inflammatory response in RAW 264.7 macrophage cells. METHODS: In vitro cell culture studies of LPS stimulated RAW 264...
April 6, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28622621/development-of-an-ultra-fast-liquid-chromatography-tandem-mass-spectrometry-method-for-simultaneous-determination-of-seven-flavonoids-in-rat-plasma-application-to-a-comparative-pharmacokinetic-investigation-of-ginkgo-biloba-extract-and-single-pure-ginkgo-flavonoids
#4
Tianyang Wang, Jie Xiao, Huiping Hou, Pei Li, Ziyue Yuan, Huarong Xu, Ran Liu, Qing Li, Kaishun Bi
For deeper pharmacokinetic investigation and further curative application of ginkgo flavonoids, a delicate, efficient and precise UFLC-MS/MS technique for synchronous quantitation of seven flavonoids, apigenin, luteolin, naringenin, quercetin, diosmetin, kaempferol and isorhamnetin in rat plasma has been established. After mixing with the internal standard (IS) linarin, bio-samples were pretreated via ethyl acetate for liquid-liquid extraction, then isolated at 0.2ml/min flow rate on a Venusil MP C18 chromatographic column (100mm×2...
May 30, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28622602/assessment-of-the-phenolic-profile-antimicrobial-activity-and-oxidative-stability-of-transgenic-perilla-frutescens-l-overexpressing-tocopherol-methyltransferase-%C3%AE-tmt-gene
#5
Bimal Kumar Ghimire, Chang Yeon Yu, Ill-Min Chung
This study evaluated the effects of enhanced concentrations of α-tocopherol and phenolic compounds on the resistance and stability of Perilla oil in transgenic Perilla frutescens plants against various tested pathogenic bacteria by over-expressing the γ-tmt gene. The concentration of phenolic compounds in the non-transgenic samples was 9313.198 ± 18.887 μg g(-1) dry weight (DW), whereas the total concentration of the transgenic samples ranged from 9118.015 ± 18.822 to 10527.612 ± 20.411 μg g(-1) DW...
June 7, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28622086/naringenin-ameliorates-behavioral-dysfunction-and-neurological-deficits-in-a-d-galactose-induced-aging-mouse-model-through-activation-of-pi3k-akt-nrf2-pathway
#6
Yan Zhang, Bin Liu, Xi Chen, Ning Zhang, Guang Li, Li-Hong Li-Hong Zhang, Li-Yan Li-Yan Tan
In this study, we evaluated the protective effects of naringenin on aging mice induced by D-gal. Open field test and Morris water maze test were performed to evaluate the effect of naringenin on behavioral dysfunction. HE staining, TUNEL staining and Nissl staining were used to estimate the effect of naringenin on neurological deficits. Furthermore, naringenin markedly activated PI3K/Akt signaling, eventually promoted the nuclear translocation of Nrf2 and induced the expressions of HO-1and NQO1. SOD, CAT and TBARS assays were conducted to evaluate oxidative stress in D-gal-induced aging mice...
June 16, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28620401/transcriptome-profiling-of-tomato-uncovers-an-involvement-of-cytochrome-p450s-and-peroxidases-in-stigma-color-formation
#7
Yan Zhang, Guiye Zhao, Yushun Li, Jie Zhang, Meijing Shi, Tayeb Muhammad, Yan Liang
Stigma is a crucial structure of female reproductive organ in plants. Stigma color is usually regarded as an important trait in variety identification in some species, but the molecular mechanism of stigma color formation remains elusive. Here, we characterized a tomato mutant, yellow stigma (ys), that shows yellow rather than typical green color in the stigma. Analysis of pigment contents revealed that the level of flavonoid naringenin chalcone was increased in the ys stigma, possibly as a result of higher accumulation of p-coumaric acid, suggesting that naringenin chalcone might play a vital role in yellow color control in tomato stigma...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28612118/microbial-transformation-of-naringenin-derivatives
#8
Yina Xiao, Ik-Soo Lee
Microbial transformations of (±)-7-O-prenylnaringenin (7-PN, 1) and (±)-7-O-allylnaringenin (7-AN, 2) have isolated four metabolites (3-6). Structures of these novel compounds were identified as 5,4'-dihydroxy-7-O-[(2E)-4-hydroxy-3-methyl-2-buten-1-yl]flavanone (3), 5,4'-dihydroxy-7-O-(2,3-dihdroxy-3-methylbutyl)flavanone (4), 5,4'-dihydroxy-7-O-(2,3-dihdroxypropyl)flavanone (5), and 5-O-β-D-glucopyranosyl-7-O-allyl-4'-hydroxyflavanone (6) based on spectroscopy. Compounds 1-6 were evaluated for their radical scavenging capacity using DPPH (2,2-diphenyl-1-picrylhydrazyl)...
June 13, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28611737/de-novo-biosynthesis-of-apigenin-luteolin-and-eriodictyol-in-the-actinomycete-streptomyces-albus-and-production-improvement-by-feeding-and-spore-conditioning
#9
Laura Marín, Ignacio Gutiérrez-Del-Río, Paula Yagüe, Ángel Manteca, Claudio J Villar, Felipe Lombó
Nutraceutical compounds as plant flavonoids play an important role in prevention and modulation of diverse heath conditions, as they exert interesting antifungal, antibacterial, antioxidant, and antitumor effects. They also possess anti-inflammatory activities in arthritis, cardiovascular disease or neurological diseases, as well as modulatory effects on the CYP450 activity on diverse drugs. Most flavonoids are bioactive molecules of plant origin, but their industrial production is sometimes hindered due to reasons as low concentration in the plant tissues, presence in only some species or as a complex mixture or inactive glycosides in plant vacuolae...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28605320/preparative-isolation-of-5-antioxidant-constituents-from-the-medicinal-mushroom-phellinus-baumii-agaricomycetes-by-high-speed-countercurrent-chromatography-and-preparative-high-performance-liquid-chromatography
#10
Libin Ye, Hongjian Zheng, Zhong Zhang, Yan Yang
Four extract fractions from the fruiting bodies of Phellinus baumii were acquired. Preliminary investigation of radical scavenging ability showed that the ethyl acetate extract exhibited the strongest antioxidant activity. To gain insight into the antioxidant mechanism, 5 antioxidant constituents were prepared from the ethyl acetate extract using high-speed countercurrent chromatography with a solvent system consisting of n-hexane, ethyl acetate, methanol, and water (0.8:3:1.5:2.5, v/v/v/v), and preparative high-performance liquid chromatography...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28593828/oral-naringenin-nanocarriers-fabrication-optimization-pharmacokinetic-and-chemotherapeutic-efficacy-assessments
#11
Sundeep Chaurasia, Ravi R Patel, Prasad Vure, Brahmeshwar Mishra
AIM: To enhance oral bioavailability and chemotherapeutic efficacy of naringenin (NG) by fabricating the NG-encapsulated Soluthin-maltodextrin-based nanocarrier (NC) system. MATERIALS & METHODS: NG-encapsulated nanocarriers (NG/NCs) were developed, and in vitro physicochemically characterized. Furthermore, Wistar rats were used to evaluate the pharmacokinetic profile. Furthermore, in vitro and in vivo colorectal cancer efficacy was evaluated in BALB/c mice-bearing colon-26 cells...
June 2017: Nanomedicine
https://www.readbyqxmd.com/read/28591691/naringenin-protects-keratinocytes-from-oxidative-stress-injury-via-inhibition-of-the-nod2-mediated-nf-%C3%AE%C2%BAb-pathway-in-pemphigus-vulgaris
#12
Junqin Liang, Yilinuer Halipu, Fengxia Hu, Buwajieer Yakeya, Wenjing Chen, Huan Zhang, Xiaojing Kang
Naringenin is known to have anti-oxidative activity; however, the effect of naringenin on the progression of pemphigus vulgaris (PV) still remains unclear. This study aims to analyze the effect of naringenin on HaCaT cell apoptosis and oxidative damage under the treatment of PV serum. The results showed that PV serum significantly induced cell apoptosis compared with the control group; whereas, comparing with PV group, naringenin inhibited cell apoptosis. Moreover, PV serum increased the expression of bax and caspase-3, and decreased the expression of bcl-2; but naringenin significantly suppressed the expression of bax and caspase-3, induced the expression of bcl-2...
June 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28573351/mitigating-potential-of-melissa-officinale-against-as-3-induced-cytotoxicity-and-transcriptional-alterations-of-hsp70-and-hsp27-in-fish-channa-punctatus-bloch
#13
Shraddha Dwivedi, Manoj Kumar, Sunil P Trivedi
The mitigating potential of Melissa officinale (MO) (Lamiaceae) against arsenite (As(3+))-induced oxidative stress, cytogenotoxicity, and expression of stress genes in fish, Channa punctatus (Bloch), teleost, was explored. After confirming the composition of MO extract, caffeic acid (0.96%), hesperidin (1.73%), naringenin (7.70%), lutenolin (3.29%), kaempferol (11.46%) and hesperetin (6.24%), by HPLC-PDA analysis, the experiment was set up in six groups (G1-G6), each containing 10 specimens. Blood, muscle, gills and liver tissues of control and treated fishes were excised at an interval of 24 till 96 h...
July 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28567424/effect-of-naringenin-quercetin-and-sesamin-on-xenobiotica-metabolizing-cyp1a-and-cyp3a-in-mice-offspring-after-maternal-exposure-to-persistent-organic-pollutants
#14
Nadezhda Pilipenko, Erik Ropstad, Ruth Halsne, Galia Zamaratskaia
The aim of the present study was to evaluate in vitro effects of dietary phytochemicals naringenin, quercetin, and sesamin on the activities of ethoxy- (EROD; CYP1A) and benzyloxy- (BROD; CYP3A) resorufin O-dealkylases after the exposure to the cocktail of persistent organic pollutants (POPs). CD-1 mice were exposed from weaning, through gestation and lactation to a defined mixture of POPs. Hepatic microsomes were prepared from their female offspring at postnatal day 42. Hepatic EROD and BROD activity were evaluated in the presence of quercetin, naringenin, and sesamin at nine concentrations from 5 to 100000 nM...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28551260/fatty-acid-and-phenolic-profiles-of-almond-grown-in-serbia
#15
Slavica D Čolić, Milica M Fotirić Akšić, Kristina B Lazarević, Gordan N Zec, Uroš M Gašić, Dragana Č Dabić Zagorac, Maja M Natić
Almond production is not typical for Serbia however the existence of natural populations and unexpectedly suitable agro-climatic conditions initiated this kind of study. Total oil content and concentrations of the fatty acids, total phenolic content and radical-scavenging activity were determined in the kernel oil of 20 local almond selections originating from North Serbia and cultivars 'Marcona', 'Texas' and 'Troito'. Sixteen fatty acids were identified and quantified, with the most abundant being oleic acid and linoleic acid...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28543037/naringenin-responsive-riboswitch-based-fluorescent-biosensor-module-for-escherichia-coli-co-cultures
#16
Yu Xiu, Sungho Jang, J Andrew Jones, Nicholas A Zill, Robert J Linhardt, Qipeng Yuan, Gyoo Yeol Jung, Mattheos A G Koffas
The ability to design and construct combinatorial synthetic metabolic pathways has far exceeded our capacity for efficient screening and selection of the resulting microbial strains. The need for high-throughput rapid screening techniques is of upmost importance for the future of synthetic biology and metabolic engineering. Here we describe the development of a RNA riboswitch-based biosensor module with dual fluorescent reporters, and demonstrate a high-throughput flow cytometry-based screening method for identification of naringenin over producing Escherichia coli strains in co-culture...
May 20, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28539727/bioassay-guided-isolation-and-identification-of-antioxidant-flavonoids-from-cyclotrichium-origanifolium-labill-manden-and-scheng
#17
Abdussamat Guzel, Huseyin Aksit, Mahfuz Elmastas, Ramazan Erenler
BACKGROUND: Medicinal and aromatic plants play a significant role in drug discovery and development process. Flavonoids, revealing a wide spectrum of biological activities, extensively found in plants are important secondary metabolites. MATERIALS AND METHODS: Aerial parts of Cyclotrichium origanifolium were collected, dried, and boiled in water then extracted with hexane, ethyl acetate, and n-butanol. Total phenolic content, DPPH(•) scavenging activity, reducing power (FRAP) activity, and ABTS(•+) scavenging activity assays were applied for all extracts...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28534300/formulation-and-evaluation-of-naringenin-nanosuspensions-for-bioavailability-enhancement
#18
Sonia Gera, Sreekanth Talluri, Nagarjun Rangaraj, Sunitha Sampathi
The clinical potential of naringenin (NRG) is compromised due to its poor aqueous solubility and low oral bioavailability. The study is aimed at addressing these issues by means of naringenin nanosuspensions (NRG-NS) formulated using polyvinylpyrrolidone (PVP K-90) as stabiliser via antisolvent sonoprecipitation method. Optimisation of sonication time, drug concentration and stabilisers was done based on particle size. Characterisation of pure NRG and NRG-NS was carried out by scanning electron microscopy, differential scanning calorimetry (DSC), x-ray powder diffractometry (XRD) and Fourier transform infrared spectroscopy (FTIR)...
May 22, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28530609/phenolic-compounds-of-the-australian-native-herb-prostanthera-rotundifolia-and-their-biological-activities
#19
Kitty S C Tang, Izabela Konczak, Jian Zhao
The chemical identity and bioactivities of phenolic components of the Australian native herb Prostanthera rotundifolia were studied. Phenolic compounds were extracted with 80% (v/v) aqueous methanol and purified by liquid chromatography. The antioxidant capacity of the extract and its inhibiting activity against α-glucosidase, pancreatic lipase and hyaluronidase were determined. Phenolic compounds were identified by a combination of HPLC-PDA, LC-high resolution MS (LC-HRMS), LC-tandem MS (LC-MS/MS) and nuclear magnetic resonance (NMR) spectroscopy...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28525714/characterization-of-bitter-compounds-via-modulation-of-proton-secretion-in-human-gastric-parietal-cells-in-culture
#20
Kathrin I Liszt, Joachim Hans, Jakob P Ley, Elke Köck, Veronika Somoza
Humans perceive bitterness via around 25 different bitter receptors. Therefore, the identification of antagonists remains a complex challenge. We previously demonstrated several bitter tasting compounds such as caffeine to induce acid secretion in the stomach and in a human gastric tumor cell line (HGT-1). Here, the results of a fluorescent-based in vitro assay using HGT-1 cells and a human sensory panel testing nine selected potential bitter modulators with or without the bitter compounds caffeine or theobromine, were compared...
May 19, 2017: Journal of Agricultural and Food Chemistry
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