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naringenin

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https://www.readbyqxmd.com/read/29225663/high-throughput-detection-of-antioxidants-in-mulberry-fruit-using-correlations-between-high-resolution-mass-and-activity-profiles-of-chromatographic-fractions
#1
Ye Ji Park, Si Hyun Seong, Min Sun Kim, Sang Wan Seo, Mee Ree Kim, Hyun Sik Kim
Background: Plant extracts contain a huge variety of pharmacologically active substances. Conventionally, various chromatographic methods must be applied several times to purify functional compounds to measure their functional activity. However, conventional purification methods are time-consuming and expensive due to the laborious purification process. Recently, a high-throughput discovery method that replaces such time-consuming purification processes was introduced; this method uses 15 T ultra-high-resolution Fourier transform ion cyclotron resonance mass spectrometry (15 T FT-ICR MS) and a high-throughput screening method...
2017: Plant Methods
https://www.readbyqxmd.com/read/29224841/metal-ion-improved-complexation-countercurrent-chromatography-for-enantioseparation-of-dihydroflavone-enantiomers
#2
Chao Han, Wenli Wang, Guimin Xue, Dingqiao Xu, Tianyu Zhu, Shanshan Wang, Pei Cai, Jianguang Luo, Lingyi Kong
Cu(II) ion was selected as an additive to improve the enantioseparation efficiency of three dihydroflavone enantiomers in high-speed counter-current chromatography (HSCCC), using hydroxypropyl-β-cyclodextrin (HP-β-CyD) as the chiral selector. The influences of important parameters, including the metal ion, the concentrations of HP-β-CyD and the Cu(II) ion, and the sample size were investigated. Under optimal conditions, three dihydroflavone enantiomers, including (±)-hesperetin, (±)-naringenin, and (±)-farrerol, were successfully enantioseparated...
December 6, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29223569/isolated-mangiferin-and-naringenin-exert-antidiabetic-effect-via-ppar%C3%AE-glut4-dual-agonistic-action-with-strong-metabolic-regulation
#3
Ashok K Singh, Vinit Raj, Amit K Keshari, Amit Rai, Pranesh Kumar, Atul Rawat, Biswanath Maity, Dinesh Kumar, Anand Prakash, Arnab De, Amalesh Samanta, Bolay Bhattacharya, Sudipta Saha
In this study, we isolated two compounds from the leaves of Salacia oblonga (SA1, mangiferin and SA2, naringenin), and their structures were confirmed by infrared spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, and mass spectrometry. SA1 and SA2 were orally administered to streptozotocin-induced diabetic rats at 50 and 100 mg/kg daily for 15 days. Blood glucose level, serum lipid profile, oxidative stress parameters, histopathology, docking, molecular parameters, and NMR-based metabolic perturbation studies were performed to investigate the pharmacological activities of SA1 and SA2...
December 6, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29215718/involvement-of-smad3-pathway-in-atrial-fibrosis-induced-by-elevated-hydrostatic-pressure
#4
Wei Wei, Fang Rao, Fangzhou Liu, Yumei Xue, Chunyu Deng, Zhaoyu Wang, Jiening Zhu, Hui Yang, Xin Li, Mengzhen Zhang, Yongheng Fu, Wensi Zhu, Zhixin Shan, Shulin Wu
Hypertension is a main risk factor for atrial fibrillation, but the direct effects of hydrostatic pressure on the atrial fibrosis are still unknown. The present study investigated whether hydrostatic pressure is responsible for atrial fibrosis, and addressed a potential role of the Smad pathway in this pathology. Biochemical assays were used to study regulation and expression of fibrotic factors in spontaneously hypertensive rats (SHRs) and Wistar rats, and in cardiac fibroblasts (CFs) cultured under standard (0 mmHg) and elevated (20, 40 mmHg) hydrostatic pressure...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29211032/bioavailability-of-bergamot-citrus-bergamia-flavanones-and-biological-activity-of-their-circulating-metabolites-in-human-pro-angiogenic-cells
#5
Valentina Spigoni, Pedro Mena, Federica Fantuzzi, Michele Tassotti, Furio Brighenti, Riccardo C Bonadonna, Daniele Del Rio, Alessandra Dei Cas
Myeloid angiogenic cells (MACs) play a key role in endothelial repairing processes and functionality but their activity may be impaired by the lipotoxic effects of some molecules like stearic acid (SA). Among the dietary components potentially able to modulate endothelial function in vivo, (poly)phenolic compounds represent serious candidates. Here, we apply a comprehensive multidisciplinary approach to shed light on the prospects of Bergamot (Citrus bergamia), a citrus fruit rich in flavanones and other phenolic compounds, in the framework of lipotoxicity-induced MACs impairment...
December 6, 2017: Nutrients
https://www.readbyqxmd.com/read/29207043/naringenin-induces-laxative-effects-by-upregulating-the-expression-levels-of-c-kit-and-scf-as-well-as-those-of-aquaporin-3-in-mice-with-loperamide-induced-constipation
#6
Jianqiao Yin, Yichao Liang, Dalu Wang, Zhaopeng Yan, Hongzhuan Yin, Di Wu, Qi Su
Constipation is a common affliction which causes discomfort and affects the quality of life of affected individuals. Naringenin (NAR), a natural flavonoid widely found in citrus fruits and tomatoes, has been reported to exhibit various pharmacological effects, such as anti-inflammatory, anti-atherogenic, anti-mutagenic, hepatoprotective and anticancer effects. Increasing evidence has indicated that NAR has potential for use in the treatment of constipation. Thus, the aim of this study was to evaluate the laxative effects of NAR in mice with loperamide-induced (Lop-induced) constipation...
December 1, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29200729/rapid-quantitative-analysis-of-naringenin-in-the-fruit-bodies-of-inonotus-vaninii-by-two-phase-acid-hydrolysis-followed-by-reversed-phase-high-performance-liquid-chromatography-ultra-violet
#7
Xia Guohua, Ruirong Pan, Rui Bao, Yanru Ge, Cunshan Zhou, Yuping Shen
Introduction: Sanghuang is one of mystical traditional Chinese medicines recorded earliest 2000 years ago, that included various fungi of Inonotus genus and was well-known for antitumor effect in modern medicine. Inonotus vaninii is grown in natural forest of Northeastern China merely and used as Sanghuang commercially, but it has no quality control specification until now. This study was to establish a rapid method of two-phase acid hydrolysis followed by reversed phase-high performance liquid chromatography-ultra violet (RP-HPLC-UV) to quantify naringenin in the fruit body of I...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29198856/naringenin-glucuronidation-in-liver-and-intestine-microsomes-of-humans-monkeys-rats-and-mice
#8
Takashi Isobe, Susumu Ohkawara, Sadayuki Ochi, Toshiko Tanaka-Kagawa, Hideto Jinno, Nobumitsu Hanioka
Naringenin, a flavanone found in citrus fruits, is mainly metabolized into glucuronide(s) by UDP-glucuronosyltransferase (UGT) enzymes in mammals. In the present study, the glucuronidation of naringenin in the liver and intestine microsomes of humans, monkeys, rats, and mice was examined. The kinetics of 7-glucuronidation in human liver and intestine microsomes followed the Michaelis-Menten model. Kinetics in mouse liver and intestine microsomes also followed the Michaelis-Menten model, whereas those in monkey and rat liver microsomes fit the biphasic model...
November 30, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29193236/inhibitory-effect-of-naringenin-via-il-13-level-regulation-on-thymic-stromal-lymphopoietin-induced-inflammatory-reactions
#9
Na-Ra Han, Phil-Dong Moon, Ka-Jung Ryu, Na-Rae Kim, Hyung-Min Kim, Hyun-Ja Jeong
Naringenin (NG) has various beneficial properties, such as anti-cancer and anti-inflammatory effects. Thymic stromal lymphopoietin (TSLP) induces mast cell proliferation and inflammatory reactions. The aim of this study was to investigate the regulatory effect of NG on TSLP-induced mast cell proliferation and inflammatory reactions using human mast cell line (HMC-1) cells. HMC-1 cells were pre-treated with NG and then treated with TSLP. HMC-1 cells proliferation was determined by quantifying bromodeoxyuridine incorporation...
November 29, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29183361/naringenin-attenuates-hepatitis-b-virus-x-protein-induced-hepatic-steatosis
#10
Hung-Jen Lin, Ko-Li Ku, I-Hsin Lin, Chia-Chou Yeh
BACKGROUND: Naringenin (Nar), a common dietary flavonoid abundantly present in fruits, vegetables, and Chinese herbs, is believed to possess strong anti-inflammatory properties and to modulate hepatic apolipoprotein and lipid synthesis. However, there are no reports describing Nar's effects on the hepatitis B virus protein X (HBx) -induced hepatic steatosis, and the detailed molecular mechanisms of the compound's effects are still unclear. METHODS: Nar was administered by oral gavage to HBx-transgenic mice from 4 to 6 weeks of age...
November 28, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29179260/naringenin-attenuates-highly-active-antiretroviral-therapy-induced-sperm-dna-fragmentations-and-testicular-toxicity-in-sprague-dawley-rats
#11
M Y Adana, E N Akang, A I Peter, A I Jegede, E C S Naidu, C Tiloke, A A Chuturgoon, O O Azu
Highly active antiretroviral therapy has evolved over the years, leading to a boost in the quality of life in people living with HIV and AIDS. However, growing evidence has shown that highly active antiretroviral therapy has deleterious effects on the testes and the overall reproductive capacity. Therefore, this study is to determine the adjuvant potential of Naringenin on highly active antiretroviral therapy-induced perturbations in fertility of male Sprague-Dawley rats. Thirty adult male Sprague-Dawley rats were divided into six groups viz - Control; H: 30 mg/kg of highly active antiretroviral therapy (EFV, 600 mg + FTC, 200 mg + TDF, 300 mg); N40: Naringenin, 40 mg/kg; N80: Naringenin, 80 mg/kg; HN40: highly active antiretroviral therapy + Naringenin, 40 mg/kg; HN80: highly active antiretroviral therapy + Naringenin, 80 mg/kg...
November 27, 2017: Andrology
https://www.readbyqxmd.com/read/29179179/naringenin-regulates-cftr-activation-and-expression-in-airway-epithelial-cells
#12
Rui Shi, Zi-Ting Xiao, Yi-Jun Zheng, Yi-Lin Zhang, Jia-Wen Xu, Jie-Hong Huang, Wen-Liang Zhou, Pei-Bo Li, Wei-Wei Su
BACKGROUND/AIMS: Sputum symptoms are commonly seen in the elderly. This study aimed to identify an efficacious expectorant treatment stratagem through evaluating the secretion-promoting activation and cystic fibrosis transmembrane conductance regulator (CFTR) expression of the bioactive herbal monomer naringenin. METHODS: Vectorial Cl- transport was determined by measuring short-circuit current (ISC) in rat airway epithelium. cAMP content was measured by ELISA in primary cultured epithelial cells and Calu-3 cells...
November 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29174446/protective-effect-of-ethyl-acetate-fraction-of-drynaria-quercifolia-against-ccl4-induced-rat-liver-fibrosis-via-nrf2-are-and-nf%C3%AE%C2%BAb-signalling-pathway
#13
G I Anuja, V J Shine, P G Latha, S R Suja
ETHNOPHARMACOLOGICAL RELEVANCE: Drynaria quercifolia rhizome is traditionally used as hepatoprotective drug especially in chronic jaundice. AIM OF THE STUDY: The present study was undertaken to scientifically evaluate the efficacy of D. quercifolia rhizome against liver fibrosis. MATERIALS AND METHODS: D. quercifolia rhizome crude extract (DQ) and its fractions of hexane (HDQ), ethyl acetate (EDQ), butanol (BDQ) were evaluated in vitro using primary hepatocytes and RAW 264...
November 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29174382/methylated-flavonoids-as-anti-seizure-agents-naringenin-4-7-dimethyl-ether-attenuates-epileptic-seizures-in-zebrafish-and-mouse-models
#14
Daniëlle Copmans, Adriana M Orellana-Paucar, Gert Steurs, Yifan Zhang, Annelii Ny, Kenn Foubert, Vasiliki Exarchou, Aleksandra Siekierska, Youngju Kim, Wim De Borggraeve, Wim Dehaen, Luc Pieters, Peter A M de Witte
Epilepsy is a neurological disease that affects more than 70 million people worldwide and is characterized by the presence of spontaneous unprovoked recurrent seizures. Existing anti-seizure drugs (ASDs) have side effects and fail to control seizures in 30% of patients due to drug resistance. Hence, safer and more efficacious drugs are sorely needed. Flavonoids are polyphenolic structures naturally present in most plants and consumed daily with no adverse effects reported. These structures have shown activity in several seizure and epilepsy animal models through allosteric modulation of GABAA receptors, but also via potent anti-inflammatory action in the brain...
November 21, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29164416/high-throughput-and-direct-measurement-of-androgen-levels-using-turbulent-flow-chromatography-liquid-chromatography-triple-quadrupole-mass-spectrometry-tfc-lc-tqms-to-discover-chemicals-that-modulate-dihydrotestosterone-production-in-human-prostate-cancer-cells
#15
Kyungsu Kang, Lei Peng, Yu-Jin Jung, Joo Yeon Kim, Eun Ha Lee, Hee Ju Lee, Sang Min Kim, Sang Hyun Sung, Cheol-Ho Pan, Yongsoo Choi
OBJECTIVES: To develop a high-throughput screening system to measure the conversion of testosterone to dihydrotestosterone (DHT) in cultured human prostate cancer cells using turbulent flow chromatography liquid chromatography-triple quadrupole mass spectrometry (TFC-LC-TQMS). RESULTS: After optimizing the cell reaction system, this method demonstrated a screening capability of 103 samples, including 78 single compounds and 25 extracts, in less than 12 h without manual sample preparation...
November 21, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/29161813/function-analysis-of-an-udp-glycosyltransferase-involved-in-the-biosynthesis-of-polyphenolic-glucoside-in-tea-camellia-sinensis
#16
Xuecheng Zhao, Xinlong Dai, Liping Gao, Lina Guo, Juhua Zhuang, YaJun Liu, Xiubing Ma, Rui Wang, Tao Xia, Yunsheng Wang
Polyphenols are one of the largest groups of compounds that confer benefits to the health of plants and humans. Flavonol glycosides are a major ingredient of polyphenols in Camellia Sinensis. Flavonol 3-O-glycosides are characteristic astringent taste compounds in tea infusion. A polyphenolic glycosyltransferase (CsUGT72AM1) belonging to cluster III b was isolated from the tea plant. The full-length cDNA of CsUGT72AM1 is 1416 bp. It encodes 472 amino acids with a calculated molecular mass of 50.92 kDa and an isoelectric point of 5...
November 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29154867/monoamine-oxidases-inhibitors-from-colvillea-racemosa-isolation-biological-evaluation-and-computational-study
#17
Enas I Mohamed, Mohamed A Zaki, Narayan D Chaurasiya, Asmaa I Owis, Sameh AbouZid, Yan-Hong Wang, Bharathi Avula, Ahmed A Seida, Babu L Tekwani, Samir A Ross
Bioassay-guided fractionation and chemical investigation of Colvillea racemosa stems led to identification of two new α, β-dihydroxydihydrochalcones, colveol A (1) and colveol B (2) along with fifteen known compounds. The structures were elucidated via interpretation of spectroscopic data. The absolute configurations of the dihydrochalcones 1 and 2 were assigned by a combination of chemical modification and electronic circular dichroism data. The isolated compounds were evaluated for their inhibition activity toward recombinant human monoamine oxidases (rhMAO-A and -B)...
November 14, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29145059/binding-of-naringin-and-naringenin-with-hen-egg-white-lysozyme-a-spectroscopic-investigation-and-molecular-docking-study
#18
Sourav Das, Pooja Ghosh, Sudipta Koley, Atanu Singha Roy
The interactions of naringenin (NG) and naringin (NR) with Hen Egg White Lysozyme (HEWL) in aqueous medium have been investigated using UV-vis spectroscopy, steady-state fluorescence, circular dichroism (CD), Fourier Transform infrared spectroscopy (FT-IR) and molecular docking analyses. Both NG and NR can quench the intrinsic fluorescence of HEWL via static quenching mechanism. At 300K, the value of binding constant (Kb) of HEWL-NG complex (5.596±0.063×10(4)M(-1)) was found to be greater than that of HEWL-NR complex (3...
November 8, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29140707/grapefruit-flavonoid-naringenin-regulates-the-expression-of-lxr%C3%AE-in-thp-1-macrophages-by-modulating-amp-activated-protein-kinase
#19
Javier Saenz, Consuelo Santa-María, Maria Edith Reyes-Quiroz, Isabel Geniz, Juan Jiménez, Francisco Sobrino, Gonzalo Alba
The present work investigates the modulation of grapefruit flavonoid naringenin over Liver X Receptor alpha (LXRα) and its target genes in THP-1 macrophages, focusing on AMP-activated protein kinase (AMPK) implication. Naringenin induced LXRα at mRNA and protein levels besides influencing the expression of LXRα target genes ABCA1, ABCG1 (ATP-binding cassette A1 and G1), and SREBP1c (sterol response element binding protein 1c) in THP-1 macrophages. The increased LXRα mRNA and protein expression was reverted when AMPK was inhibited by its chemical inhibitor, compound C or by transfection with AMPK α1 and α2 siRNA...
November 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29140457/genistein-specific-g6dt-gene-for-the-inducible-production-of-wighteone-in-lotus-japonicus
#20
Jinyue Liu, Wenbo Jiang, Yaying Xia, Xuemin Wang, Guoan Shen, Yongzhen Pang
Prenylated isoflavonoids were found in several legume plants, and they possess various biological activities that play important roles in both plant defense and human health. However, it is still unknown whether prenylated isoflavonoids are present in the model legume plant L. japonicus. In the present study, we found that the prenylated isoflavonoid wighteone was produced in L. japonicus when the leaf was supplemented with genistein. Furthermore, a novel prenyltransferase gene LjG6DT was identified, which shared high similarity and was closely related with several known prenyltransferase genes involved in isoflavonoid biosynthesis...
November 10, 2017: Plant & Cell Physiology
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