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https://www.readbyqxmd.com/read/28427292/chemical-analyses-and-in-vitro-and-in-vivo-toxicity-of-fruit-methanol-extract-of-sechium-edule-var-nigrum-spinosum
#1
Itzen Aguiñiga-Sánchez, Jorge Cadena-Íñiguez, Edelmiro Santiago-Osorio, Guadalupe Gómez-García, Víctor Manuel Mendoza-Núñez, Juana Rosado-Pérez, Mirna Ruíz-Ramos, Víctor Manuel Cisneros-Solano, Edgar Ledesma-Martínez, Angel de Jesus Delgado-Bordonave, Ramón Marcos Soto-Hernández
CONTEXT: Sechium edule (Jacq.) Sw. (Cucurbitaceae) is used in ethnomedicine, but the diversity of the varietal groups of this species has not often been considered. This is important because we previously reported that different variety of species exhibit different activities across different tumor cell lines. OBJECTIVE: This study investigates the chemical composition and biological activities of extracts obtained from S. edule var. nigrum spinosum. MATERIALS AND METHODS: The leukemia P388 cell line and mononuclear bone marrow cells (MNCBMs) were treated with the extract at a concentration ranging from 40 to 2370 μg/mL for cytotoxicity and viability assays...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28416882/chemical-composition-antiproliferative-and-antioxidant-activity-of-differently-processed-ganoderma-lucidum-ethanol-extracts
#2
Sonja Veljović, Mile Veljović, Ninoslav Nikićević, Saša Despotović, Siniša Radulović, Miomir Nikšić, Lana Filipović
The content of phenolic compounds (TPC) and glucans, as well as the effectiveness of antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts were determined and compared. The content of glucans (total, α- and β-) strongly depended on the extraction time and particle size, but only interaction of these parameters influenced the TPC. Gallic acid, quercetin, trans-cinnamic acid, kaempferol, hesperetin and naringenin were detected in extracts by HPLC-DAD. The most abundant phenols were hesperetin (1...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28415935/naringenin-improves-the-healing-process-of-thermally-induced-skin-damage-in-rats
#3
Abdulaziz S Al-Roujayee
Objective To evaluate the effect of the phenolic compound naringenin on thermal burn-induced inflammatory responses and oxidative stress in rats. Methods First degree thermal burn injuries were induced in shaved rats by 10 s immersion of the back surface in water at 90℃. Naringenin treatment (25, 50 and 100 mg/kg/day) was initiated 24 h following burn injury, and continued for 7 days. On treatment day 7, serum tumour necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, nitric oxide (NO), prostaglandin (PG)E2, caspase-3, leukotriene (LT)-B4 and nuclear factor (NF)-κB levels were quantified...
April 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28395574/naringenin-a-bioflavonoid-impairs-the-reproductive-potential-of-male-mice
#4
Pavitra Ranawat, Nikita Bakshi
Present study analyzed the effect of naringenin, a bioflavonoid, on male reproductive function in adult mouse, after intraperitoneal treatment with varying concentrations of naringenin (2, 8 and 20 mg/kg b.wt.) for two weeks. Naringenin increased the generation of reactive oxygen species and lipid peroxidation in the testis with concomitant decrease in sperm count and motility in a dose-dependent manner. Activities of antioxidant enzymes catalase, superoxide dismutase, glutathione peroxidase and levels of reduced glutathione were found to be decreased in a dose-dependent manner...
April 10, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28386313/the-citrus-flavanone-naringenin-protects-myocardial-cells-against-age-associated-damage
#5
Eleonora Da Pozzo, Barbara Costa, Chiara Cavallini, Lara Testai, Alma Martelli, Vincenzo Calderone, Claudia Martini
In recent years, the health-promoting effects of the citrus flavanone naringenin have been examined. The results have provided evidence for the modulation of some key mechanisms involved in cellular damage by this compound. In particular, naringenin has been revealed to have protective properties such as an antioxidant effect in cardiometabolic disorders. Very recently, beneficial effects of naringenin have been demonstrated in old rats. Because aging has been demonstrated to be directly related to the occurrence of cardiac disorders, in the present study, the ability of naringenin to prevent cardiac cell senescence was investigated...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28385728/disrupting-flavone-synthase-ii-alters-lignin-and-improves-biomass-digestibility
#6
Pui Ying Lam, Yuki Tobimatsu, Yuri Takeda, Shiro Suzuki, Masaomi Yamamura, Toshiaki Umezawa, Clive Lo
Lignin, a ubiquitous phenylpropanoid polymer in vascular plant cell walls, is primarily derived from oxidative couplings of monolignols (p-hydroxycinnamyl alcohols). It was recently discovered that a wide range of grasses, including cereals, utilize a member of flavonoid, tricin (3',5'-dimethoxyflavone), as a natural co-monomer with monolignols for cell wall lignification. Previously, we established that cytochrome P450 93G1 is a flavone synthase II (OsFNSII) indispensable for the biosynthesis of soluble tricin-derived metabolites in rice (Oryza sativa L...
April 6, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28385098/pharmacological-evaluation-of-the-anxiolytic-like-effects-of-lippia-graveolens-and-bioactive-compounds
#7
María Eva González-Trujano, Laura Yunuen Hernández-Sánchez, Verónica Muñoz Ocotero, Alejandro Dorazco-González, Patricia Guevara Fefer, Eva Aguirre-Hernández
CONTEXT: Lippia species (Verbenaceae) are widely used in Latin America and Africa as folk medicine for their tranquilizing properties. OBJECTIVE: To evaluate the anxiolytic-like effects and safety of Lippia graveolens Kunth. by exploring its aqueous and organic leaf extracts and identifying the responsible chemical constituents. MATERIAL AND METHODS: Aqueous and organic extracts (hexane, ethyl acetate and methanol) were pharmacologically evaluated at several doses...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28372240/glucosylation-of-flavonol-and-flavanones-by-bacillus-cyclodextrin-glucosyltransferase-to-enhance-their-solubility-and-stability
#8
Young-Su Lee, Jang-Bin Woo, Soo-In Ryu, Seong-Kwon Moon, Nam Soo Han, Soo-Bok Lee
Enzymatically modified isoquercitrin (EMIQ), oligoglucosyl naringenin-7-(glucose [G]), and oligoglucosyl hesperetin (H)-7-G were produced via oligoglucosylation of quercetin-3-glucose, naringenin-7-G (prunin), and H-7-G, respectively, by cyclodextrin glucosyltransferase from Bacillus macerans. The aim was to explore the oligoglucosylation and the resulting changes in physicochemical properties. Water solubility of EMIQ, oligoglucosyl prunin, and oligoglucosyl H-7-G enormously increased in comparison with that of their aglycones...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28370954/citrus-flavonoid-naringenin-reduces-mammary-tumor-cell-viability-adipose-mass-and-adipose-inflammation-in-obese-ovariectomized-mice
#9
Jia-Yu Ke, Taylor Banh, Yung-Hsuan Hsiao, Rachel M Cole, Shana R Straka, Lisa D Yee, Martha A Belury
SCOPE: Obesity-related metabolic dysregulation may be a link between obesity and postmenopausal breast cancer. Naringenin, a flavonoid abundant in grapefruits, displays beneficial effects on metabolic health and tumorigenesis. Here, we assessed the effects of naringenin on mammary tumor cell growth in vitro and in obese ovariectomized mice. METHODS AND RESULTS: Naringenin inhibited cell growth, increased phosphorylation of AMP-activated protein kinase (AMPK), down-regulated CyclinD1 expression, and induced cell death in E0771 mammary tumor cells...
March 30, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28355351/naringenin-regulates-production-of-matrix-metalloproteinases-in-the-knee-joint-and-primary-cultured-articular-chondrocytes-and-alleviates-pain-in-rat-osteoarthritis-model
#10
C C Wang, L Guo, F D Tian, N An, L Luo, R H Hao, B Wang, Z H Zhou
Inflammation of cartilage is a primary symptom for knee-joint osteoarthritis. Matrix metalloproteinases (MMPs) are known to play an important role in the articular cartilage destruction related to osteoarthritis. Naringenin is a plant-derived flavonoid known for its anti-inflammatory properties. We studied the effect of naringenin on the transcriptional expression, secretion and enzymatic activity of MMP-3 in vivo in the murine monosodium iodoacetate (MIA) osteoarthritis model. The assessment of pain behavior was also performed in the MIA rats...
March 23, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28352360/naringenin-inhibits-migration-of-lung-cancer-cells-via-the-inhibition-of-matrix-metalloproteinases-2-and-9
#11
Huai-Lu Chang, Yuh-Ming Chang, Shih-Chan Lai, Ke-Min Chen, Kuan-Chu Wang, Tsu-Ting Chiu, Fu-Hsin Chang, Li-Sung Hsu
Lung cancer is among the most common causes of cancer-related mortality. It has a high mortality rate and resistance to chemotherapy due to its high metastatic potential. Naringenin, a bioactive compound identified in several fruits, displays anti-inflammatory and antitumor effects. Furthermore, naringenin mitigates the migration of several human cancer cell types. However, the effects of naringenin on lung cancer remain unclear. The current study investigated the mechanisms of naringenin on the migration of lung cancer A549 cells...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28349704/lc-esi-ms-ms-profiling-of-phenolics-in-the-leaves-of-eleutherococcus-senticosus-cultivated-in-the-west-europe-and-anti-hyaluronidase-and-anti-acetylcholinestarase-activities
#12
Rafał Kuźniewski, Daniel Załuski, Marta Olech, Piotr Banaszczak, Renata Nowak
Neither secondary metabolites of the spring leaves nor the autumn leaves of Eleutherococcus senticosus species cultivated in Poland, or the bioactivity are known. The richest in polyphenols was the autumn leaves (171.1 mg/g DE), while in flavonoids the spring leaves (107.9 mg/g DE). Using LC-ESI-MS/MS, protocatechuic acid has been identified as the most abundant compound in the spring and autumn leaves (200 and 70 μg/g DE, respectively). Amongst flavonoids, naringenin 7-O-glucoside occurred in the largest amount (20 and 10 mg/g DE in the spring and autumn leaves, respectively)...
March 28, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28347309/chemical-composition-and-pharmacological-activities-of-pisum-sativum
#13
Md Nazmul Hasan Zilani, Tamanna Sultana, S M Asabur Rahman, Md Anisuzzman, Md Amirul Islam, Jamil A Shilpi, Md Golam Hossain
BACKGROUND: Consumption of vegetables has been proven to be effective in the prevention of different diseases. Traditionally edible aerial part of Pisum sativum L. subsp. sativum (Fabaceae) is used to treat diabetes, heart diseases and as blood purifier. Present study was aimed to explore the traditional use of aerial parts of P. sativum as a source of antidiabetic agent. In addition, antioxidant activity and chemical composition was carried out. METHODS: Total polyphenol content was spectrophotometrically determined using Folin Chiocalteu's reagent while the flavonoids by aluminum chloride colorimetric assay...
March 27, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28343014/natural-lipids-enriched-self-nano-emulsifying-systems-for-effective-co-delivery-of-tamoxifen-and-naringenin-systematic-approach-for-improved-breast-cancer-therapeutics
#14
Premjeet Singh Sandhu, Rajendra Kumar, Sarwar Beg, Sanyog Jain, Varun Kushwah, O P Katare, Bhupinder Singh
The nano-miceller drug delivery carriers of tamoxifen (TMX) having natural ingredients like polyunsaturated fatty acid (PUFA) with self-nano-emulsifying properties was developed with naringenin (NG) in a synergistic manner i.e. TMX-NG-SNEDDS. The optimized nano-formulation revealed complete drug release in 30 min and >80% permeation in 45 min. Superior cellular uptake potential (4.6-6.5-fold) of the TMX-NG-SNEDDS using Caco-2 cells while cytotoxicity study on MCF-7 cells indicated significant results (P<0...
March 23, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28341245/in-vitro-anti-diabetic-activity-of-flavonoids-and-pheophytins-from-allophylus-cominia-sw-on-ptp1b-dppiv-alpha-glucosidase-and-alpha-amylase-enzymes
#15
D G Semaan, J O Igoli, L Young, E Marrero, A I Gray, E G Rowan
BACKGROUND: Ethno-botanical information from diabetic patients in Cuba led to the identification of Allophylus cominia as a possible source of new drugs for the treatment of type 2 diabetes mellitus (T2-DM). EXPERIMENTAL: Chemical characterization of the extracts from A. cominia was carried out using chromatographic and spectroscopic methods. The extracts were tested for their activity on PTP1B, DPPIV, α-glucosidase enzymes and α-amylase. RESULTS: The flavonoid rich fractions from A...
March 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28336842/sers-based-flavonoid-detection-using-ethylenediamine-%C3%AE-cyclodextrin-as-a-capturing-ligand
#16
Jae Min Choi, Eunil Hahm, Kyeonghui Park, Daham Jeong, Won-Yeop Rho, Jaehi Kim, Dae Hong Jeong, Yoon-Sik Lee, Sung Ho Jhang, Hyun Jong Chung, Eunae Cho, Jae-Hyuk Yu, Bong-Hyun Jun, Seunho Jung
Ethylenediamine-modified β-cyclodextrin (Et-β-CD) was immobilized on aggregated silver nanoparticle (NP)-embedded silica NPs (SiO₂@Ag@Et-β-CD NPs) for the effective detection of flavonoids. Silica NPs were used as the template for embedding silver NPs to create hot spots and enhance surface-enhanced Raman scattering (SERS) signals. Et-β-CD was immobilized on Ag NPs to capture flavonoids via host-guest inclusion complex formation, as indicated by enhanced ultraviolet absorption spectra. The resulting SiO₂@Ag@Et-β-CD NPs were used as the SERS substrate for detecting flavonoids, such as hesperetin, naringenin, quercetin, and luteolin...
January 6, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28322845/metformin-like-antidiabetic-cardio-protective-and-non-glycemic-effects-of-naringenin-molecular-and-pharmacological-insights
#17
REVIEW
Annah Nsoaki Nyane, Thabiso Bethwel Tlaila, Tanki Gabriel Malefane, Dudu Edith Ndwandwe, Peter Mark Oroma Owira
Metformin is a widely used drug for the treatment of type 2 diabetes (T2D). Its blood glucose-lowering effects are initially due to inhibition of hepatic glucose production and increased peripheral glucose utilization. Metformin has also been shown to have several beneficial effects on cardiovascular risk factors and it is the only oral antihyperglycaemic agent thus far associated with decreased macrovascular complications in patients with diabetes. Adenosine Monophosphate Activated-Protein Kinase (AMPK) is a major cellular regulator of lipid and glucose metabolism...
March 18, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28317253/correlation-between-the-potency-of-flavonoids-for-cytochrome-c-reduction-and-inhibition-of-cardiolipin-induced-peroxidase-activity
#18
Ricardo Lagoa, Alejandro K Samhan-Arias, Carlos Gutierrez-Merino
There are large differences between flavonoids to protect against apoptosis, a process in which cytochrome c (Cyt c) plays a key role. In this work, we show that 7 of 13 flavonoids studied have a capacity to reduce Cyt c similar or higher than ascorbate, the flavonols quercetin, kaempferol and myricetin, flavanol epigallocatechin-gallate, anthocyanidins cyanidin and malvidin, and the flavone luteolin. In contrast, the kaempferol 3(O)- and 3,4'(O)-methylated forms, the flavanone naringenin, and also apigenin and chrysin, had a negligible reducing capacity...
March 20, 2017: BioFactors
https://www.readbyqxmd.com/read/28315389/variations-in-the-chemical-composition-and-content-of-salicylic-glycosides-in-the-bark-of-salix-purpurea-from-natural-locations-and-their-significance-for-breeding
#19
Paweł Sulima, Mirosława Krauze-Baranowska, Jerzy Andrzej Przyborowski
Willow bark is one of the few plant raw materials which contain natural active substances that have analgesic, fever-reducing, anti-inflammatory and anti-rheumatic effects. Salix purpurea, listed as widespread and common in many countries, belongs to the willow species with the highest content of salicylic compounds. The chemical composition and content of major salicylic glycosides (SGs) in the bark of S. purpurea genotypes from natural locations were investigated in this study to evaluate their applicability for pharmaceutical processing and creative breeding...
April 2017: Fitoterapia
https://www.readbyqxmd.com/read/28293083/pharmacokinetics-and-pharmacodynamics-of-da-cheng-qi-decoction-in-the-liver-of-rats-with-severe-acute-pancreatitis
#20
Yu-Mei Zhang, Hong-Yu Ren, Xian-Lin Zhao, Juan Li, Jun-Yi Li, Fu-Sheng Wu, Hang Su, Wen-Fu Tang
AIM: To explore the pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction (DCQD) in the liver of rats with severe acute pancreatitis (SAP) based on an herbal recipe tissue pharmacology hypothesis. METHODS: Healthy male Sprague-Dawley rats were randomly divided into a sham operation group (SOG); a model group (MG); and low-, median- and high-dose treatment groups (LDG, MDG, and HDG, respectively). Different dosages (6, 12 and 24 g/kg for the LDG, MDG, and HDG, respectively) of DCQD were administered to the rats with SAP...
February 28, 2017: World Journal of Gastroenterology: WJG
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