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Haiyan Lin, Zhenting Zhou, Weichao Zhong, Peng Huang, Ning Ma, Yuqing Zhang, Chuying Zhou, Yuling Lai, Shaohui Huang, Haiyan An, Xuegang Sun, Lei Gao, Zhiping Lv
Alcoholic liver disease (ALD) includes a spectrum of hepatic abnormalities that range from isolated alcoholic steatosis to steatohepatitis and cirrhosis. Naringenin, a predominant flavanone in grapefruit, increases resistance to oxidative stress and inflammation and protects against multiple organ injury in various animal models. However, the specific mechanisms responsible for protection against alcoholic injury are poorly understood. In the present study, we aimed to investigate the effect of naringenin on alcoholic events and the molecular regulatory mechanisms of naringenin in the liver and whole body of zebrafish larvae following exposure to 350 mmol/l ethanol for 32 h...
September 19, 2017: Oncology Reports
Bhishma P Patel, Pawan K Singh
OBJECTIVES: The aim of this study was to review and highlight traditional and ethnobotanical uses, phytochemical constituents, IP status, biological activity and pharmacological activity of Viscum articulatum. METHODS: Thorough literature searches were performed on Viscum articulatum, and data were analysed for reported traditional uses, pharmacological activity, phytochemicals present and patents filed. Scientific and patent databases such as PubMed, Science Direct, Google Scholar, Google patents, USPTO and Espacenet were searched using different keywords...
October 16, 2017: Journal of Pharmacy and Pharmacology
Sundeep Chaurasia, Ravi R Patel, Prasad Vure, Brahmeshwar Mishra
To improve the bioavailability and anticancer potential of naringenin (NRG) by developing a drug-loaded polymeric nano-delivery system. NRG-loaded eudragit E100 nanoparticle (NRG-EE100-NPs) system was developed, and physicochemically characterized. In vivo pharmacokinetic and in vitro cytotoxicity ability of the NRG-EE100-NPs was investigated. In vivo anticancer activity was evaluated in murine BALB/c mice-bearing colorectal tumor. The NRG-EE100-NPs had an optimum mean particle size (430.42±5.78nm), polydispersity index (0...
October 12, 2017: Journal of Pharmaceutical Sciences
Xiaoxuan Li, Xiaobin Yao, Yin Xiao, Yong Wang
A novel native cyclodextrin (CD) chiral stationary phase (CSP) with single triazole-bridge at CD C2 position (CSP1) was prepared by anchoring mono(2(A)-azido-2(A)-deoxy)-β-CD onto alkynyl silica via click chemistry. The effect of CD orientation on single layer CD-CSP's enantioseparation was comprehensively investigated using CSP1 (reversed orientation) and our previously reported CSP2 (C6 single triazole-bridge, normal orientation) as well as a commercial CD-CSP (Cyclobond I 2000, hybrid orientation) by separating several groups of analytes in chiral high performance liquid chromatography...
October 16, 2017: Analytica Chimica Acta
Cathy Su, Alexis H Haskins, Chisato Omata, Yasushi Aizawa, Takamitsu A Kato
High consumption of dietary flavonoids might contribute to a reduction of cancer risks. Quercetin and its glycosides have PARP inhibitory effects and can induce selective cytotoxicity in BRCA2-deficient cells by synthetic lethality. We hypothesized that common flavonoids in diet naringenin, hesperetin and their glycosides have a similar structure to quercetin, which might have comparable PARP inhibitory effects, and can induce selective cytotoxicity in BRCA2-deficient cells. We utilized Chinese hamster V79 wild type, V-C8 BRCA2-deficient and its gene-complemented cells...
October 12, 2017: Pharmaceuticals
Lingtao Jin, Wenfeng Zeng, Fayun Zhang, Chunling Zhang, Wei Liang
Ungoverned activation of innate and adaptive immunity results in acute inflammatory disease, such as bacteria-induced endotoxemia and fulminant hepatitis by virus infection. Thus, therapeutic control of inflammation is crucial for clinical management of many human diseases. In murine models of LPS- and Con A-induced liver injury, we found that naringenin, a natural predominant flavanone, is capable of protecting against lethality induced by LPS and preventing inflammation-induced organ injury. The protective effect of naringenin is mediated by reducing the levels of several inflammatory cytokines...
October 9, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
Fatemeh Aghakhani, Navaz Kharazin, Zahra Lori Gooini
INTRODUCTION: Phlomis is one of the medicinal genera of Lamiaceae. This genus has unique medicinal properties. Consequently, appropriate methods need to be described for the identification of the chemical compounds. OBJECTIVE: A liquid chromatography tandem mass spectrometry (LC-MS/MS) technique on a triple quadrupole mass spectrometer (TQMS) was used for separation and identification of leaf flavonoid compounds for seven Phlomis species including Phlomis kurdia, Ph...
October 5, 2017: Phytochemical Analysis: PCA
Ewa Romaszko, Urszula Marzec-Wróblewska, Anna Badura, Adam Buciński
The content of certain ingredients of human milk, such as flavonoids, depend on the types and amounts of plant products consumed and may vary from woman to woman. The aim of the study was to determine to what extent consumption of an average amount of grapefruit juice (250 ml) affected naringenin content in human milk. A total of 14 breastfeeding mothers were included in the study. The subjects remained on a diet with restricted intake of naringenin for a total of five days except on the third day, when they drank a single serving of 250 ml of grapefruit juice...
2017: PloS One
Minghong Zhao, Chao Li, Fujun Shen, Meijuan Wang, Ning Jia, Chunbin Wang
The aim of the present study was to explore the effect of naringenin on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in a mouse model, as well as the underlying mechanism. The animals were randomly assigned to four groups: PBS-treated healthy control (Control), LPS-induced ALI (LPS), vehicle-treated ALI (LPS + Vehicle), and naringenin-treated ALI (LPS + Nar) group. Naringenin (100 mg/kg) was administered orally for 4 consecutive days, starting 3 days prior to induction of ALI. The survival rates of mice, lung wet/dry weight ratios, lung injury score, protein levels of bronchoalveolar lavage fluid (BALF), lactate dehydrogenase (LDH) activity in the BALF, lung myeloperoxidase (MPO) activity, the number of infiltrated neutrophils and reactive oxygen species (ROS) levels (H2O2 and malondialdehyde) were assessed...
September 2017: Experimental and Therapeutic Medicine
Karina M Chávez-Suárez, María I Ortega-Vélez, Ana I Valenzuela-Quintanar, Marcia Galván-Portillo, Lizbeth López-Carrillo, Julián Esparza-Romero, María S Saucedo-Tamayo, María R Robles-Burgueño, Susana A Palma-Durán, María L Gutiérrez-Coronado, Melissa M Campa-Siqueiros, Patricia Grajeda-Cota, Graciela Caire-Juvera
There has been substantial interest in phytoestrogens, because of their potential effect in reducing cancer and heart disease risk. Measuring concentrations of phytoestrogens in urine is an alternative method for conducting epidemiological studies. Our objective was to evaluate the urinary excretion of phytoestrogens as biomarkers for dietary phytoestrogen intake in Mexican women. Participants were 100 healthy women from 25 to 80 years of age. A food frequency questionnaire (FFQ) and a 24 h recall were used to estimate habitual and recent intakes of isoflavones, lignans, flavonols, coumestrol, resveratrol, naringenin, and luteolin...
September 29, 2017: Nutrients
Jiansong Fang, Zengrui Wu, Chuipu Cai, Qi Wang, Yun Tang, Feixiong Cheng
Natural products with diverse chemical scaffolds have been recognized as an invaluable source of compounds in drug discovery and development. However, systematic identification of drug targets for natural products at the human proteome level via various experimental assays is highly expensive and time-consuming. In this study, we proposed a systems pharmacology infrastructure to predict new drug targets and anticancer indications of natural products. Specifically, we reconstructed a global drug-target network with 7,314 interactions connecting 751 targets and 2,388 natural products and built predictive network models via a balanced substructure-drug-target network-based inference approach...
October 13, 2017: Journal of Chemical Information and Modeling
Zuzana Lackova, Hana Buchtelova, Zaneta Buchtova, Borivoj Klejdus, Zbynek Heger, Martin Brtnicky, Jindrich Kynicky, Ondrej Zitka, Vojtech Adam
This study shows the effects of spices, and their phenolic and flavonoid compounds, on prostate cell lines (PNT1A, 22RV1 and PC3). The results of an MTT assay on extracts from eight spices revealed the strongest inhibitory effects were from black pepper and caraway seed extracts. The strongest inhibitory effect on prostatic cells was observed after the application of extracts of spices in concentration of 12.5 mg·mL(-1). An LC/MS analysis identified that the most abundant phenolic and flavonoid compounds in black pepper are 3,4-dihydroxybenzaldehyde and naringenin chalcone, while the most abundant phenolic and flavonoid compounds in caraway seeds are neochlorogenic acid and apigenin...
September 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Kaihua Wang, Zhenzhen Chen, Longjian Huang, Bing Meng, Xinmei Zhou, Xiaodong Wen, Ding Ren
Oxidative stress and mitochondrial dysfunction are considered to be major contributing factors in the development and progression of many neurodegenerative diseases. Naringenin (NAR) is an abundant flavanone in the Citrus genus and has been found to exert antioxidant, anticarcinogenic and antimutagenic effects. However, the potential underlying mechanism of its antioxidant effects remains unclear. In the present study, the authors investigated the antioxidant effect of NAR on neurons in vitro. Neurons isolated from the brains of Sprague-Dawley rats were randomly divided into a control group, model group, NAR-L group, NAR-M group and NAR-H group...
September 13, 2017: International Journal of Molecular Medicine
Yi-Yun Wu, Cui-Ping Chen, Chao-Xiang Ren, Qing-Hua Wu, Jiang Chen, Jin Pei
The average yield of safflower blooming from 1 to 7 day was recorded and calculated, HPLC was used to detect the percentage composition of HYSA,quercetin,naringenin and kaempferol, and the real-time PCR was used to analyze the expression of chs and chi. The average yield,percentage composition of HYSA and naringenin as well as functional genes' expression presented similar trends. The average yield reached the highest peak at the third day, showing highpositive correlation with the contents of HYSA (r=0.756,P<0...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Rong Fan, Tong Pan, An-Li Zhu, Mei-Hong Zhang
BACKGROUND: Naringenin, a bioflavonoid present in various species of citrus fruit, tomatoes and grapes, has been shown to have various pharmacological effects. We evaluated the anti-arthritic potential of naringenin in formaldehyde-induced inflammation and complete Freund's adjuvant (CFA)-induced arthritis. METHODS: For both evaluations, rats were divided into groups of six. Different doses of naringenin (5, 10 and 20mg/kg) were used in the models. Body weight and the arthritic index were assessed...
April 13, 2017: Pharmacological Reports: PR
Suzana Guimaraes Leitão, Gilda Guimarães Leitão, Douglas K T Vicco, João Paulo Barreto Pereira, Gustavo de Morais Simão, Danilo R Oliveira, Rita Celano, Luca Campone, Anna Lisa Piccinelli, Luca Rastrelli
Lippia origanoides (Verbenaceae) is an important Brazilian medicinal plant, also used for culinary purposes. Most chemical studies with this plant have been focused on its volatile composition. In this work, we combined High-Speed Counter-current Chromatography (HSCCC) and High Performance Liquid Chromatography coupled to Ultra Violet detection and High Resolution Mass Spectrometry (HPLC-UV-HRMS(n)) methodologies to access the non-volatile chemical composition of L. origanoides. The crude ethanol extract of L...
September 6, 2017: Journal of Chromatography. A
Xingwen Zhou, Jiyuan Li, Yulin Zhu, Sui Ni, Jinling Chen, Xiaojuan Feng, Yunfeng Zhang, Shuangquan Li, Hongguang Zhu, Yuanguang Wen
The golden camellia, Camellia nitidissima Chi., is a well-known ornamental plant that is known as "the queen of camellias" because of its golden yellow flowers. The principal pigments in the flowers are carotenoids and flavonol glycosides. Understanding the biosynthesis of the golden color and its regulation is important in camellia breeding. To obtain a comprehensive understanding of flower development in C. nitidissima, a number of cDNA libraries were independently constructed during flower development. Using the Illumina Hiseq2500 platform, approximately 71...
2017: Frontiers in Plant Science
Li-Qiu Zou, Cai-Xia Wang, Xue-Jun Kuang, Ying Li, Chao Sun
Flavonoids are the valuable components in medicinal plants, which possess a variety of pharmacological activities, including anti-tumor, antioxidant and anti-inflammatory activities. There is an unambiguous understanding about flavonoids biosynthetic pathway, that is,2S-flavanones including naringenin and pinocembrin are the skeleton of other flavonoids and they can transform to other flavonoids through branched metabolic pathway. Elucidation of the flavonoids biosynthetic pathway lays a solid foundation for their synthetic biology...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Ismail Koyuncu, Abdurrahim Kocyigit, Ataman Gonel, Erkan Arslan, Mustafa Durgun
The aim of this study is to examine the protective effect of naringenin-oxime (NOX) on cisplatin-induced major organ toxicity and DNA damage in rats. Thirty-five male Wistar albino rats were equally split into five groups as follows: control (i.p., 0.1 ml of saline), Cis administration (i.p., 7 mg/kg b.w.), NOX treatment (i.p., 20 mg/kg b.w., daily for ten days), Cis + NOX20, and Cis + NOX40 combination (i.p., 20 and 40 mg/kg b.w., daily for ten days). Serum and peripheral blood mononuclear leukocytes (PBMC) were obtained from blood...
2017: Biochemistry Research International
Andrea Mosqueda-Solís, Arrate Lasa, Saioa Gómez-Zorita, Itziar Eseberri, Catalina Picó, María P Portillo
This study was designed to analyze the anti-adipogenic effect of fifteen phenolic compounds from various chemical groups in 3T3-L1 pre-adipocytes. Cells were treated with 25 μM, 10 μM or 1 μM of apigenin, luteolin, catechin, epicatechin, epigallocatechin, genistein, daizein, naringenin, hesperidin, quercetin, kaempferol, resveratrol, vanillic acid, piceatannol and pterostilbene for 8 days. At 25 μM lipid accumulation was reduced by all the compounds, with the exception of catechin, epicatechin and epigallocatechin...
September 8, 2017: Food & Function
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