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https://www.readbyqxmd.com/read/29688705/modularisation-and-response-curve-engineering-of-a-naringenin-responsive-transcriptional-biosensor
#1
Brecht De Paepe, Jo Maertens, Bartel Vanholme, Marjan De Mey
To monitor the intra- and extracellular environment of micro-organisms and to adapt their metabolic processes accordingly, scientists are reprogramming nature's myriad of transcriptional regulatory systems into transcriptional biosensors which are able to detect small molecules and, in response, express specific output signals of choice. However, the naturally occurring response curve, the key characteristic of biosensor circuits, is typically not in line with the requirements for real-life biosensor applications...
April 24, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29684853/naringenin-improve-hepatitis-c-virus-infection-induced-insulin-resistance-by-increase-pten-expression-via-p53-dependent-manner
#2
Benli Jia, Dongsheng Yu, Gang Yu, Yunsheng Cheng, Yang Wang, Xiaoqiang Yi, Xiaoping Li, Yong Wang
Hepatitis C virus (HCV) infection may finally lead to hepatocellular carcinoma (HCC), and also associated with insulin resistance (IR). Naringenin (NGEN), a flavonoid found in grapefruit, has anti-virus, anti-inflammation and insulin sensitization effects. In the present study we examined the effects of NGEN on HCV core protein (HCVCP) infection induced IR and investigated the mechanism involved. We found that NGEN ameliorated IR and glucose tolerance in HCVCP infected mice by increase the phosphorylation of Akt at both Ser473 and Thr308 site, and also inhibited the inflammation cytokine production and T-cell immune response...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29679633/influence-of-naringenin-on-the-biofilm-formation-of-streptococcus-mutans
#3
Jiaxi Yue, Hongye Yang, Siying Liu, Fangfang Song, Jingmei Guo, Cui Huang
OBJECTIVES: To evaluate the effect of naringenin on the biofilm formation of Streptococcus mutans (S. mutans), and to investigate its mechanisms of action and biological toxicity. METHODS: Minimum inhibitory concentrations, growth curves, and biofilm inhibition rates of naringenin were determined to assess its antimicrobial effect on S. mutans. The morphology of S. mutans and the structure of biofilm were observed by FESEM and CLSM. Bacterial aggregation, bacterial surface hydrophobicity, and real-time PCR for gtfB, gtfC, comD, comE, and luxS mRNA expression were assessed to preliminarily investigate the mechanisms of action...
April 18, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29676094/-two-new-compounds-from-smilax-glaucochina
#4
Ji-Cheng Shu, Min Liu, Gen-Hua Zhu, Rong-Hua Liu, Feng Shao, Hui-Lian Huang
A new sesquiterpenes named glaucochinarol A (1) and a new phenylpropane glycoside named glcacochinaside A (2), together with six known ones, including trichothecolone (3), β-D-(6-O-trans-feruloyl)fructofuranosyl-α-D-O-glucopyranoisde (4), 3,4,5-trimethoxyphenyl-β-D-glucopyranoside (5), (4R)-p-menth-1-ene-7,8-diol-7-O-β-D-glucopyranoside (6), naringenin (7), and emodin-8-O-β-glucoside (8) were isolated from smilax glaucochina warb. Their structures were elucidated on the basis of NMR, MS and published data...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29668849/qualitative-and-quantitative-analyses-of-active-constituents-in-trollius-ledebourii
#5
Man Liao, Xiaoye Cheng, Xia Zhang, Xinpeng Diao, Caijuan Liang, Lantong Zhang
Trollius ledebourii has been more involved in Mongolian medicine and is often used as a type of tea for heat-clearing and detoxifying in the populus. In this study, a rapid and sensitive method was established for the qualitative and quantitative analyses of the major constituents in T. ledebourii. Ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry was developed for the identification of the multi-constituents in T. ledebourii. A total of 37 chemical constituents in T...
April 13, 2018: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29667505/a-comprehensive-screening-shows-that-ergothioneine-is-the-most-abundant-antioxidant-in-the-wild-macrofungus-phylloporia-ribis-ryvarden
#6
Hengqiang Zhao, Minmin Zhang, Qian Liu, Xiaoli Wang, Ruixuan Zhao, Yanling Geng, Tityee Wong, Shengbo Li, Xiao Wang
The polar and non-polar extracts from the authenticated wild mushroom Phylloporia ribis were separated by hydrophilic interaction liquid chromatography (HILIC) and by reverse phase (RP)-HPLC, respectively. A split valve separated the eluents into two fractions for free-radical scavenging analysis and for structural identification. Forty-six compounds showed scavenging activity of the stable-free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). The structures of 8 antioxidants (inosine, caffeic acid, ergothioneine, p-hydroxybenzoic acid, adenosine, 3,4-dihydroxybenzaldehyde, apigenin, and naringenin) are characterized by Mass Spectrometer...
April 3, 2018: Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
https://www.readbyqxmd.com/read/29662846/antioxidant-activities-of-selected-berries-and-their-free-esterified-and-insoluble-bound-phenolic-acid-contents
#7
Ji-Sang Kim
To explore the potential of berries as natural sources of bioactive compounds, the quantities of free, esterified, and insoluble-bound phenolic acids in a number of berries were determined. In addition, the antioxidant activities of the berries were determined using 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity, ferric reducing antioxidant power, and Trolox equivalent antioxidant capacity assays, in addition to determination of their metal ion chelating activities. Furthermore, several phenolic compounds were detected using high-performance liquid chromatography...
March 2018: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29655693/molecular-modeling-and-in-vitro-approaches-towards-cholinesterase-inhibitory-effect-of-some-natural-xanthohumol-naringenin-and-acyl-phloroglucinol-derivatives
#8
Ilkay Erdogan Orhan, Dariusz Jedrejek, F Sezer Senol, Ramin Ekhteiari Salmas, Serdar Durdagi, Iwona Kowalska, Lukasz Pecio, Wieslaw Oleszek
BACKGROUND: Many natural products, particularly phenolic compounds, have been reported to have a strong inhibition against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), the key enzymes in the pathology of Alzheimer's disease (AD). HYPOTHESIS: Therefore, we hypothesized that some xanthahumol, naringenin, and acyl phloroglucinol derivatives (1-14) isolated from Humulus lupulus L. (hops) may have an inhibitory potential against AChE and BChE. METHODS: Inhibitory potential of compounds 1-14 were tested against AChE and BChE using ELISA microtiter assay...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29649170/uflc-q-tof-ms-ms-based-screening-and-identification-of-flavonoids-and-derived-metabolites-in-human-urine-after-oral-administration-of-exocarpium-citri-grandis-extract
#9
Xuan Zeng, Weiwei Su, Yuying Zheng, Hong Liu, Panlin Li, Weijian Zhang, Yuting Liang, Yang Bai, Wei Peng, Hongliang Yao
Exocarpium Citri grandis (ECG) is an important Traditional Chinese Medicine (TCM) for the treatment of cough and phlegm, and the flavonoids contained were considered the main effective components. To date, the systematic chemical profiling of these flavonoids and derived in vivo metabolites in human have not been well investigated. ECG was extracted using boiling water and then provided to volunteers for oral administration. Following the ingestion, urine samples were collected from volunteers over 48 h. The extract and urine samples were analyzed using ultra-fast liquid chromatography/quadrupole-time-of-flight tandem mass spectrometry (UFLC-Q-TOF-MS/MS) system to screen and identify flavonoids and derived in vivo metabolites...
April 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29626522/the-acute-effects-of-citrus-flavanones-on-the-metabolism-of-glycogen-and-monosaccharides-in-the-isolated-perfused-rat-liver
#10
Gilson Soares do Nascimento, Renato Polimeni Constantin, Eduardo Hideo Gilglioni, Cristiane Vizioli de Castro Ghizoni, Adelar Bracht, Karina Sayuri Utsunomiya, Nair Seiko Yamamoto, Emy Luiza Ishii-Iwamoto, Jorgete Constantin, Rodrigo Polimeni Constantin
Citrus flavanones are often linked to their antihyperglycemic properties. This effect may be in part due to the inhibition of hepatic gluconeogenesis through different mechanisms. One of the possible mechanisms appears to be impairment of oxidative phosphorylation, which may also interfere with glycogen metabolism. Based on these facts, the purpose of the present study was to investigate the effects of three citrus flavanones on glycogenolysis in the isolated perfused rat liver. Hesperidin, hesperetin, and naringenin stimulated glycogenolysis and glycolysis from glycogen with concomitant changes in oxygen uptake...
April 4, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29617563/protein-surface-structural-recognition-in-inactive-areas-a-new-immobilization-strategy-for-acetylcholinesterase
#11
Jianxiong Diao, Xiaolu Yu, Lin Ma, Yuanqing Li, Ying Sun
This work reported a new method of design for the immobilization of acetylcholinesterase (AChE) based on its molecular structure to improve its sensitivity and stability. The immobilization binding site on the surface of AChE was determined using MOLCAD's multi-channel functionality. Then, 11 molecules ((+)-catechin, (-)-epicatechin, (-)-gallocatechin, hesperetin, naringenin, quercetin, taxifolin, (-)-epicatechin gallate, flupirtine, atropine, and hyoscyamine) were selected from the ZINC database (about 50000 molecules) as candidate affinity ligands for AChE...
April 4, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29580480/chemical-characterization-complemented-with-chemometrics-for-the-botanical-origin-identification-of-unifloral-and-multifloral-honeys-from-india
#12
Apramita Devi, Jitender Jangir, Anu-Appaiah K A
Chemical fingerprints based on FTIR spectra, phenolics and volatiles were studied for a total of 30 honey types of eight different botanical origin i.e. litchi, neem, ginger, eucalyptus, lemon (unifloral) and Kashmiri white, BR Hills & Pan India honey (Multifloral). Chemometrics based on principal component analysis (PCA) was used as a complementary tool for chemical fingerprint of honey. ATR-FTIR had a good predictive capability to discriminate among honey when conjugated with chemometric tools, providing the rapid first-line of classification for honey...
May 2018: Food Research International
https://www.readbyqxmd.com/read/29576857/-citrus-aurantium-naringenin-prevents-osteosarcoma-progression-and-recurrence-in-the-patients-who-underwent-osteosarcoma-surgery-by-improving-antioxidant-capability
#13
Lirong Zhang, Xiaohua Xu, Tiechao Jiang, Kunzhe Wu, Chuanbo Ding, Zhen Liu, Xuanhe Zhang, Tianhua Yu, Changlong Song
Citrus aurantium is rich in flavonoids, which may prevent osteosarcoma progression, but its related molecular mechanism remains unclear. Flavonoids were extracted from C. aurantium and purified by reparative HPLC. Each fraction was identified by using electrospray ionisation mass spectrometry (ESI-MS). Three main components (naringin, naringenin, and hesperetin) were isolated from C. aurantium . Naringenin inhibited the growth of MG-63 cells, whereas naringin and hesperetin had no inhibitory function on cell growth...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29570361/optimizing-the-flavanone-core-toward-new-selective-nitrogen-containing-modulators-of-abc-transporters
#14
Ricardo J Ferreira, Rafael Baptista, Alexis Moreno, Patricia G Madeira, Ruttiros Khonkarn, Hélène Baubichon-Cortay, Daniel Jva Dos Santos, Pierre Falson, Maria-José U Ferreira
AIM: Naringenin (1), isolated in large amount from the aerial parts of Euphorbia pedroi, was chemically derivatized to yield 18 imine derivatives (2-19) and three alkylated derivatives through a Mannich-type reaction (20-22) that were tested as multidrug resistance (MDR) reversers in cancer cells. Results/methodology: While hydrazone (2-4) and azine (5-13) derivatives showed an improvement in their MDR reversal activities against the breast cancer resistance protein, carbohydrazides 14-19 revealed an enhancement in MDR reversal activity toward the multidrug resistance protein 1...
March 23, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29556193/pharmacokinetic-study-of-7-compounds-following-oral-administration-of-fructus-aurantii-to-depressive-rats
#15
Xianhua Zhang, Linran Han, Jin Liu, Qiuyue Xu, Yuxin Guo, Wan Zheng, Jian Wang, Xi Huang, Ping Ren
In the present study, the pharmacokinetics of multi-components (naringenin, nobiletin, meranzin hydrate, narirutin, naringin, hesperidin, and neohesperidin) were investigated in acute depressive rats following oral administration of Fructus Aurantii (Zhi-Qiao, ZQ) extract (20 g/kg). A rapid and reliable liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was established to quantitatively or qualitatively analyze the 7 absorbed ingredients in the plasma, hippocampus and cortex of acute depressive rats...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29549386/ion-channels-induced-by-antimicrobial-agents-in-model-lipid-membranes-are-modulated-by-plant-polyphenols-through-surrounding-lipid-media
#16
Svetlana S Efimova, Anastasiia A Zakharova, Roman Ya Medvedev, Olga S Ostroumova
The potential therapeutic applications of plant polyphenols in various neurological, cardiovascular, metabolic and malignant disorders determine the relevance of studying the molecular mechanisms of their action on the cell membranes. Here, the quantitative changes in the physical parameters of model bilayer lipid membranes upon the adsorption of plant polyphenols were evaluated. It was shown that butein and naringenin significantly decreased the intrinsic dipole potential of cholesterol-free and cholesterol-enriched membranes...
March 16, 2018: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29534519/hyaluronic-acid-decorated-naringenin-nanoparticles-appraisal-of-chemopreventive-and-curative-potential-for-lung-cancer
#17
Poonam Parashar, Meena Rathor, Monika Dwivedi, Shubhini A Saraf
Lung carcinoma is the most common cancer in men and second in women (preceded by breast cancer) worldwide. Around 1 in 10 of all cancers diagnosed in men, lung cancer contributed to a total fraction of 20% cancer deaths. Naringenin (NAR) is well known for its chemopreventive properties since ancient times but lacks an appropriate delivery carrier. The objective of present study was to expand the functionality of naringenin loaded poly caprolactone (PCL) nanoparticles in terms of release, chemoprevention and therapeutics...
March 12, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29533635/homoisoflavonoids-are-potent-glucose-transporter-2-glut2-inhibitors-a-potential-mechanism-for-the-glucose-lowering-properties-of-polygonatum-odoratum
#18
Huijun Wang, Mark I Fowler, David J Messenger, Leon A Terry, Xuelan Gu, Luxian Zhou, Ruimin Liu, Juan Su, Songshan Shi, Jose Juan Ordaz-Ortiz, Guoping Lian, Mark J Berry, Shunchun Wang
Foods of high carbohydrate content such as sucrose or starch increase postprandial blood glucose concentrations. The glucose absorption system in the intestine comprises two components: sodium-dependent glucose transporter-1 (SGLT1) and glucose transporter 2 (GLUT2). Here five sappanin-type (SAP) homoisoflavonoids were identified as novel potent GLUT2 inhibitors, with three of them isolated from the fibrous roots of Polygonatum odoratum (Mill.) Druce. SAP homoisolflavonoids had a stronger inhibitory effect on 25 mM glucose transport (41...
March 19, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29531477/do-bioflavonoids-in-juniperus-virginiana-heartwood-stimulate-oviposition-in-the-ladybird-coleomegilla-maculata
#19
Eric W Riddick, Zhixin Wu, Fred J Eller, Mark A Berhow
Maximizing the reproductive potential of ladybird beetles fed factitious foods or artificial diets, in lieu of natural prey, is a major challenge to cost-effective mass rearing for augmentative biological control. In this study, we tested the hypothesis that compounds in redcedar, Juniperus virginiana , stimulate oviposition in the ladybird Coleomegilla maculata . We also tested the prediction that several bioflavonoids, identified in heartwood fractions, elicited this behavioral response. Phenolic compounds were extracted from J...
2018: International Journal of Insect Science
https://www.readbyqxmd.com/read/29529676/evaluation-of-the-neurobehavioral-properties-of-naringin-in-swiss-mice
#20
Benneth Ben-Azu, Ekene Enekabokom Nwoke, Solomon Umukoro, Adegbuyi Oladele Aderibigbe, Abayomi Mayowa Ajayi, Ezekiel O Iwalewa
OBJECTIVES: This study was carried out to investigate the neurobehavioral properties of naringin, a flavonoid compound formed from naringenin on behavioral models in mice. METHOD: The neurobehavioral property of naringin (2.5, 5 and 10 mg/kg) administered intraperitoneally (i.p.) was assessed on novelty-induced rearing, locomotor behavior using open field test; anxiolytic effect was evaluated using hole-board, light and dark box, and elevated-plus maze paradigms...
March 12, 2018: Drug Research
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