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https://www.readbyqxmd.com/read/28214430/development-of-evidence-based-practice-in-academic-service-partnerships-experiences-of-working-life-representatives-from-social-and-health-care-sectors
#1
Hanna-Leena Melender
Learning about how to develop and lead the implementation of evidence based practice (EBP) in services is an important part of the education of developers and managers for the social and health care sectors. In order to develop this teaching and to support the development of EBP in services, a Teaching Development Effort (TDE) was conducted by establishing academic service partnerships (ASPs) and connecting Master's students' assignments with them. The TDE was conducted as a part of a larger project whose main aims were to strengthen, develop and renew transfers of knowledge and competence between higher education institutions and workplaces, and to strive for a more multidisciplinary quality in workplace innovations...
February 9, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/28214381/the-value-of-reflectance-confocal-microscopy-in-diagnosis-of-flat-pigmented-facial-lesions-a-prospective-study
#2
E Wurm, G Pellacani, C Longo, H P Soyer, S Gonzalez, R Hofmann-Wellenhof, V Ahlgrimm-Siess, P Guitera, C Sinz, H Kittler
BACKGROUND: Flat pigmented facial lesions are difficult to diagnose even with dermatoscopy. It is controversial how additional information obtained by in vivo reflectance confocal microscopy (RCM) impacts the diagnosis and management. OBJECTIVE: To examine what in vivo reflectance confocal microscopy of flat pigmented facial lesions adds to clinical examination using dermatoscopy including digital dermatoscopic monitoring. METHODS: We prospectively collected 70 cases of flat pigmented facial lesions and recorded diagnoses and management decisions by experts based on direct clinical examination aided by dermatoscopy including digital dermatoscopic monitoring and by remote experts who reviewed the corresponding confocal images...
February 18, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28214372/canonical-and-cellular-pathways-timing-gamete-release-in-acropora-digitifera-okinawa-japan
#3
Y Rosenberg, T Doniger, S Harii, F Sinniger, O Levy
Natural light cycles are important for synchronizing behavioral and physiological rhythms over varying time-periods in both plants and animals. An endogenous clock, regulated by positive and negative elements, interacting in feedback loops, control these rhythms. Many corals exhibit diel cycles of polyp expansion and contraction entrained by solar light patterns and monthly cycles of spawning or planulation that correspond to nocturnal lunar light cycles. However, despite considerable interest in studies of coral reproduction, there is currently not enough molecular information about the cellular pathways involved with synchronizing spawning/planulation in broadcast spawners and brooders...
February 18, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28214371/the-risk-of-depression-suicidal-ideation-and-suicide-attempt-in-patients-with-psoriasis-psoriatic-arthritis-or-ankylosing-spondylitis
#4
J J Wu, R B Penfold, P Primatesta, T K Fox, C Stewart, S P Reddy, A Egeberg, J Liu, G Simon
BACKGROUND: Sparse information is available concerning mental health issues in psoriasis, psoriatic arthritis (PsA), and ankylosing spondylitis (AS) patients. OBJECTIVE: To estimate risk of depression, suicidal ideation, and suicide attempt in patients with psoriasis, PsA, and AS, respectively, compared with the general population. METHODS: This population-based cohort study analyzed 36,214 psoriasis patients, 5,138 PsA patients, and 1,878 AS patients who were frequency-matched with a general population cohort...
February 18, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28214361/identification-of-arabidopsis-genic-and-non-genic-promoters-by-paired-end-sequencing-of-tss-tags
#5
Mutsutomo Tokizawa, Kazutaka Kusunoki, Hiroyuki Koyama, Atsushi Kurotani, Tetsuya Sakurai, Yutaka Suzuki, Tomoaki Sakamoto, Tetsuya Kurata, Yoshiharu Y Yamamoto
Information about transcription start sites (TSSs) provides foundational data for analyses of promoter architecture. In this report, we used paired- and single-end deep sequencing to analyze Arabidopsis TSS tags from several libraries prepared from roots, shoots, flowers, and etiolated seedlings. The clustering of approximately 33 million mapped TSS tags led to the identification of 324,461 promoters that covered 79.7% (21,672/27,206) of protein-coding genes in the Arabidopsis genome. In addition, we identified intragenic, antisense, and Orphan promoters that were not associated with any gene models...
February 18, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28214351/evidence-based-and-precision-medicine-two-of-a-kind
#6
W J Fokkens
In the last two decades, an enormous expansion of evidence has been produced in upper airway research. When writing the first EPOS document in 2005 only 5 RCT per year were performed in the area of CRS, in 2007 this changed to 25 per year and it became even higher in the recent years. Randomized Controlled Trials (RCTs) are the "gold standard" for evaluating treatment outcomes providing information on treatments "efficacy". To make life easier for clinicians, systematic reviews and meta-analysis further condense the available evidence...
February 18, 2017: Rhinology
https://www.readbyqxmd.com/read/28214304/efficacy-and-safety-of-fumaric-acid-esters-in-combination-with-phototherapy-in-patients-with-moderate-to-severe-plaque-psoriasis-fast
#7
Peter Weisenseel, Kristian Reich, Wiebke Griemberg, Katharina Merten, Christine Gröschel, Natalie Nunez Gomez, Kirsi Taipale, Beate Bräu, Ina Zschocke
BACKGROUND: While treatment of patients with moderate-to-severe psoriasis using a combination of fumaric acid esters (FAE, Fumaderm(®) ) and phototherapy (UV) is common practice, there have been hardly any studies investigating this regimen. Available information is limited to data from a small pilot study. The objective of the present study was to evaluate FAE/UV combination therapy in a larger patient cohort with moderate-to-severe psoriasis. PATIENTS AND METHODS: In this prospective noninterventional multicenter study, data from patients treated with FAE/UV combination therapy was assessed with regard to efficacy (PGA' PASI, DLQI, EQ-5D), safety, and dosage over a twelve-month period...
February 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28214293/ultra-high-frequency-ultrasound-of-fascicles-in-the-median-nerve-at-the-wrist
#8
Michael S Cartwright, Vanessa Baute, James B Caress, Francis O Walker
INTRODUCTION: An ultra high-frequency (70 MHz) ultrasound device has recently been approved for human use. This study was conducted to determine if this device facilitates counting of fascicles within the median nerve at the wrist. METHODS: Twenty healthy volunteers underwent imaging of the median nerve at the wrist bilaterally. The number of fascicles in each nerve was counted by two independent raters. RESULTS: The mean fascicle number was 22...
February 18, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28214290/evaluate-the-efficacy-and-safety-of-anti-epileptic-medications-for-partial-seizures-of-epilepsy-a-network-meta-analysis
#9
Teng Zhao, Xuemin Feng, Jingyao Liu, Jiguo Gao, Chunkui Zhou
Epilepsy is a brain and neurological disorder with high prevalence. It was reported that more than 70% of epileptic seizures were controlled by anti-epileptic medications, whereas the lack of evidence with respect to head-to-head comparisons motivated researchers to seek alternative approaches that are able to provide deep insights into the profile of anti-epileptic medications. In this study, we performed a network meta-analysis (NMA) to evaluate the efficacy and safety of anti-epileptic medications for partial seizures of epilepsy...
February 18, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28214288/an-accelerator-mass-spectrometry-enabled-microtracer-study-to-evaluate-the-first-pass-effect-on-the-absorption-of-yh4808
#10
Anhye Kim, Byung-Yong Yu, Stephen R Dueker, Kwang-Hee Shin, Hwa Suk Kim, Hyungmi Ahn, Joo-Youn Cho, Kyung-Sang Yu, In-Jin Jang, Howard Lee
(14) C-labeled YH4808, a novel potassium-competitive acid blocker, was intravenously administered as a microtracer at 80 μg (11.8 kBq or 320 nCi) concomitantly with the non-radiolabeled oral drug at 200 mg to determine the absolute bioavailability and to assess the effect of pharmacogenomics on the oral absorption of YH4808. The absolute bioavailability was low and highly variable (mean, 10.1%; range, 2.3-19.3%), and M3 and M8, active metabolites of YH4808, were formed 22.6- and 38.5-fold higher after oral administration than intravenous administration, respectively...
February 18, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28214278/patient-parent-expectations-of-orthodontic-treatment
#11
Omolara Abiodun Obilade, Oluranti Olatokunbo da Costa, Oluwatosin Oluyemi Sanu
BACKGROUND: Expectations of orthodontic treatment may differ between the patient and their parents, as the parents' expectations may not reflect those of the child. OBJECTIVES: The aim of this study, therefore, was to determine the expectations of patients and their parents. MATERIALS AND METHODS: This was a clinic-based, comparative, cross-sectional study involving 110 patients aged between 10 and 19 years, as well as their accompanying parents or guardians...
February 14, 2017: International Orthodontics
https://www.readbyqxmd.com/read/28214272/fungal-monitoring-of-the-indoor-air-of-the-museo-de-la-plata-herbarium-argentina
#12
Andrea C Mallo, Lorena A Elíades, Daniela S Nitiu, Mario C N Saparrat
BACKGROUND: Biological agents, such as fungal spores in the air in places where scientific collections are stored, can attack and deteriorate them. AIMS: The aim of this study was to gather information on the indoor air quality of the Herbarium of Vascular Plants of the Museo de Ciencias Naturales de La Plata, Argentina, in relation to fungal propagules and inert particles. METHODS: This study was made using a volumetric system and two complementary sampling methods: (1) a non-viable method for direct evaluation, and (2) a viable method by culture for viable fungal propagules...
February 14, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28214257/a-comparison-of-two-dosing-regimens-of-asa-following-total-hip-and-knee-arthroplasties
#13
Michael J Feldstein, Sara L Low, Antonia F Chen, Laura A Woodward, William J Hozack
BACKGROUND: The purpose of this study was to compare short-term side effects of aspirin (ASA) 325 mg vs ASA 81 mg orally twice daily (PO BID) when used as thromboembolic prophylaxis following primary total joint arthroplasty. METHODS: A 1-year prospective cohort study was performed on 643 primary unilateral total joint arthroplasty patients operated on by a single surgeon. Two hundred eighty-two patients were administered ASA 325 mg PO BID and 361 patients were administered ASA 81 mg PO BID for 1 month...
January 24, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28214249/perceived-neighborhood-social-cohesion-and-preventive-healthcare-use
#14
Eric S Kim, Ichiro Kawachi
INTRODUCTION: Neighborhood social cohesion has been linked with better health and health behaviors, but its association with patterns of preventive healthcare use remains understudied. The hypothesis was that people with higher perceived neighborhood social cohesion would display increased use of preventive healthcare services. METHODS: Participants (N=7,168) were drawn from the 2006 wave of the Health and Retirement Study-a prospective and nationally representative panel study of American adults aged >50 years-and tracked for one wave (2 years)...
February 14, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28214241/improvement-of-operational-stability-of-ogataea-minuta-carbonyl-reductase-for-chiral-alcohol-production
#15
Kohsuke Honda, Mizuha Inoue, Tomohiro Ono, Kenji Okano, Yasumasa Dekishima, Hiroshi Kawabata
Directed evolution of enantio-selective carbonyl reductase from Ogataea minuta was conducted to improve the operational stability of the enzyme. A mutant library was constructed by an error-prone PCR and screened using a newly developed colorimetric assay. The stability of a mutant with two amino acid substitutions was significantly higher than that of the wild type at 50°C in the presence of dimethyl sulfoxide. Site-directed mutagenesis analysis showed that the improved stability of the enzyme can be attributed to the amino acid substitution of V166A...
February 14, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28214237/knowledge-attitudes-and-preferences-of-advance-decisions-end-of-life-care-and-place-of-care-and-death-in-hong-kong-a%C3%A2-population-based-telephone-survey-of-1067-adults
#16
Roger Yat-Nork Chung, Eliza Lai-Yi Wong, Nicole Kiang, Patsy Yuen-Kwan Chau, Janice Y C Lau, Samuel Yeung-Shan Wong, Eng-Kiong Yeoh, Jean W Woo
OBJECTIVES: According to the 2015 Quality of Death Index published by the Intelligence Unit of the Economist, Hong Kong is ranked 22nd in terms of quality of palliative care in the world, behind many other major developed countries in Asia, including Taiwan, Singapore, Japan, and South Korea. The objectives of the present study were to describe the knowledge, attitude, and preferences of the general Hong Kong adult population across different age groups regarding end-of-life (EOL) care decisions, place of care and death, as well as advance directive (AD)...
February 14, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28214235/effects-of-postacute-settings-on-readmission-rates-and-reasons-for%C3%A2-readmission-following-total-knee-arthroplasty
#17
Rodney Laine Welsh, James E Graham, Amol M Karmarkar, Natalie E Leland, Jacques G Baillargeon, Dana L Wild, Kenneth J Ottenbacher
OBJECTIVES: Examine the effects of postacute discharge setting on unplanned hospital readmissions following total knee arthroplasty (TKA) in older adults. DESIGN: Secondary analyses of 100% Medicare (inpatient) claims files. SETTING: Acute hospitals across the United States. PARTICIPANTS: Medicare fee-for-service beneficiaries ≥66 years of age who were discharged from an acute hospital following TKA in 2009-2011 (n = 608,031)...
February 14, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28214234/reablement-reactivation-rehabilitation-and-restorative-interventions-with-older-adults-in-receipt-of-home-care-a-systematic-review
#18
REVIEW
Joanie Sims-Gould, Catherine E Tong, Lutetia Wallis-Mayer, Maureen C Ashe
OBJECTIVE: To systematically review the impact of reablement, reactivation, rehabilitation, and restorative (4R) programs for older adults in receipt of home care services. DESIGN: Systematic review. DATA SOURCES: We searched the following electronic bibliographic databases: MEDLINE, EMBASE, PsycINFO, CINAHL (Cumulative Index to Nursing and Allied Health), SPORTDiscus and The Cochrane Library and reference lists. STUDY SELECTION: Randomized controlled trials that describe original data on the impact of home-based rehabilitative care and were written in English...
February 14, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28214199/primary-acinic-cell-carcinoma-of-the-lung-with-psammoma-bodies-a-case-report-and-review-of-literature
#19
Xiu-Peng Zhang, Gui-Yang Jiang, Qing-Fu Zhang, Hong-Tao Xu, Qing-Chang Li, En-Hua Wang
Salivary gland-type tumors are rare in the lung. Primary acinic cell carcinoma of the lung is extremely rare. Here, we report a case of primary acinic cell carcinoma of the lung with prominent psammoma bodies. A 31-year-old man came to our hospital with a tumor in the basal segment of the lower lobe of the right lung. The tumor tissue displayed solid, acinar, or microcystic structures at different regions. A large amount of psammoma bodies were scattered in more than half of the tumor. The majority of the tumor cells were round or polygonal in shape, with abundant acidophilic granular or vacuolated cytoplasm...
January 19, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28214193/quantification-of-the-overall-measurement-uncertainty-associated-with-the-passive-moss-biomonitoring-technique-sample-collection-and-processing
#20
J R Aboal, M T Boquete, A Carballeira, A Casanova, S Debén, J A Fernández
In this study we examined 6080 data gathered by our research group during more than 20 years of research on the moss biomonitoring technique, in order to quantify the variability generated by different aspects of the protocol and to calculate the overall measurement uncertainty associated with the technique. The median variance of the concentrations of different pollutants measured in moss tissues attributed to the different methodological aspects was high, reaching values of 2851 (ng·g(-1))(2) for Cd (sample treatment), 35...
February 14, 2017: Environmental Pollution
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