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https://www.readbyqxmd.com/read/27892708/antitumoral-effects-of-d-fraction-from-grifola-frondosa-maitake-mushroom-in-breast-cancer
#1
Eliana Noelia Alonso, María Julia Ferronato, Norberto Ariel Gandini, María Eugenia Fermento, Diego Javier Obiol, Alejandro López Romero, Julián Arévalo, María Emilia Villegas, María Marta Facchinetti, Alejandro Carlos Curino
D-Fraction is protein-bound β-1,6 and β-1,3 glucans (proteoglucan) extracted from the edible and medicinal mushroom Grifola frondosa (Maitake). The antitumoral effect of D-Fraction has long been exclusively attributed to their immunostimulatory capacity. However, in recent years increasing evidence showed that D-Fraction directly affects the viability of canine and human tumor cells, independent of the immune system. Previously, we have reported that D-Fraction modulates the expression of genes associated with cell proliferation, cell death, migration, invasion, and metastasis in MCF7 human breast cancer cells...
November 28, 2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/27649730/high-level-production-of-exopolysaccharides-by-a-cosmic-radiation-induced-mutant-m270-of-the-maitake-medicinal-mushroom-grifola-frondosa-agaricomycetes
#2
Chen Zhao, Xue-Mei Tian, Guang-Yuan Wang, Ai-Rong Song, Wen-Xing Liang
A new Grifola frondosa mutant, M270, was successfully isolated for high production of exopolysaccharides (EPSs) using cosmic radiation-induced mutagenesis. We found that the mutant M270 had a clearer and thicker EPS layer (~10 µm) adhering to mycelia than those of its parent strain 265 after Congo red staining. In the 20-L batch fermentation for M270, 10.3 g/L of EPS and 17.9 g/L of dry mycelia biomass were obtained after 204 hours of fermentation. Furthermore, a main water-soluble fraction (EP1) in the EPS was purified from M270 and then confirmed to be heteroglycan-protein complex with 91% (w/w) total carbohydrates and 9% (w/w) total proteins...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27401257/maitake-pro4x-has-anti-cancer-activity-and-prevents-oncogenesis-in-balbc-mice
#3
Agustina Roldan-Deamicis, Eliana Alonso, Belén Brie, Diego Aguilera Braico, Gabriela Andrea Balogh
The understanding of the molecular mechanisms of the immune tolerance induced by the tumoral microenvironment is fundamental to prevent cancer development or to treat cancer patients using immunotherapy. Actually, there are investigations about "addressed-drugs" against cancer cells without affecting normal cells. It could be ideal to find selective and specific compounds that only recognize and destroy tumor cells without damaging the host normal cells. For thousands of years, mushrooms have been used for medicinal purposes because of their curative properties...
September 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27329257/the-prefrontal-dectin-1-ampa-receptor-signaling-pathway-mediates-the-robust-and-prolonged-antidepressant-effect-of-proteo-%C3%AE-glucan-from-maitake
#4
Hongkun Bao, Pengzhan Ran, Ming Zhu, Lijuan Sun, Bai Li, Yangyang Hou, Jun Nie, Liping Shan, Hongliang Li, Shangyong Zheng, Xiufeng Xu, Chunjie Xiao, Jing Du
Proteo-β-glucan from Maitake (PGM) is a strong immune regulator, and its receptor is called Dectin-1. Cumulative evidence suggests that AMPA receptors are important for the treatment of depression. Here, we report that PGM treatment leads to a significant antidepressant effect in the tail suspension test and forced swim test after sixty minutes of treatment in mice. After five consecutive days of PGM treatment, this antidepressant effect remained. PGM treatment did not show a hyperactive effect in the open field test...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27151580/synergistic-apoptotic-effect-of-d-fraction-from-grifola-frondosa-and-vitamin-c-on-hepatocellular-carcinoma-smmc-7721-cells
#5
Fei Zhao, Yong-Feng Wang, Lei Song, Jia-Xin Jin, Ya-Qing Zhang, Hong-Yun Gan, Ke-Hu Yang
The aim of this study was to investigate the anticancer effect of a combination of D-fraction polysaccharide from Grifola frondosa (DFP) and vitamin C (VC) on hepatocellular carcinoma in vitro. DFP is a bioactive extract from the maitake mushroom. Anticancer activity was demonstrated using various concentrations of DFP alone or in combination with VC against the human hepatocarcinoma SMMC-7721 cell line. To investigate the anticancer mechanism, studies designed to detect cell apoptosis were conducted. Results from the MTT assay indicated that a combination of DFP (0...
May 5, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/26776013/maldi-tof-to-compare-polysaccharide-profiles-from-commercial-health-supplements-of-different-mushroom-species
#6
Marta López-García, María Sonia Dopico García, José Manuel López Vilariño, María Victoria González Rodríguez
In this work MALDI-TOF mass spectroscopy was investigated to characterise the β-glucan profiles of several commercial health supplements, without any derivatisation or purification pre-treatment. The effect of two solvents (water and dimethyl sulfoxide) and two MALDI matrices (2,5-dihydroxybenzoic acid and 2',4',6'-trihydroxyacetophenone) was first evaluated on dextran standards. MALDI-TOF was found as a useful and quick technique to obtain structural information of diverse food supplements based on mushroom extracts...
May 15, 2016: Food Chemistry
https://www.readbyqxmd.com/read/26349512/submerged-culture-mycelia-and-broth-of-the-maitake-medicinal-mushroom-grifola-frondosa-higher-basidiomycetes-alleviate-type-2-diabetes-induced-alterations-in-immunocytic-function
#7
Ya-Hui Chen, Chien-Hsing Lee, Tai-Hao Hsu, Hui-Chen Lo
Type 2 Diabetes mellitus (T2DM), a disease with impaired glucose, protein and lipid metabolism, low-grade chronic inflammation, and immune dysfunction, is a global public health crisis. We previously demonstrated that Grifola frondosa has bioactivities in improving glycemic responses in diabetic rats. Herein, we investigated the immunomodulatory effects of the submerged-culture mycelia and broth of G. frondosa on the peripheral blood cells (PBL) and splenocytes. Male Wistar rats were administered with saline (normal rats) or streptozotocin plus nicotinamide (T2DM rats) and were intragastrically administered with placebo, fermented mycelia, broth, or mycelia plus broth (1 g kg-1 day-1) for two weeks...
2015: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/26311233/hypoglycemic-effects-of-grifola-frondosa-maitake-polysaccharides-f2-and-f3-through-improvement-of-insulin-resistance-in-diabetic-rats
#8
Chun Xiao, Qingping Wu, Yizhen Xie, Jumei Zhang, Jianbin Tan
Our laboratory has previously demonstrated that Grifola frondosa polysaccharides (GFPs) showed hypoglycemic effects. This study aimed to investigate which polysaccharide-enriched fractions of GFPs were the main active constituents, and to disclose their hypoglycemic mechanism. F2 and F3 were obtained from GFPs and their hypoglycemic effects were investigated. Fasting serum glucose (FSG) levels, fasting serum insulin (FSI) levels and a homeostasis model assessment of insulin resistance (HOMA-IR) were measured, and the hepatic mRNA levels of insulin receptor (IR), insulin receptor substrate-1 (IRS-1), protein tyrosine phosphatase-1B (PTP1B), phosphatidylinositol 3-kinase (PI3K) and Akt/protein kinase B (PKB) were determined by a quantitative polymerase chain reaction (qPCR)...
November 2015: Food & Function
https://www.readbyqxmd.com/read/26297795/soluble-%C3%AE-glucan-from-grifola-frondosa-induces-tumor-regression-in-synergy-with-tlr9-agonist-via-dendritic-cell-mediated-immunity
#9
Yuki Masuda, Daiki Nawa, Yoshiaki Nakayama, Morichika Konishi, Hiroaki Nanba
The maturation of dendritic cells into more-immunostimulatory dendritic cells by stimulation with different combinations of immunologic agents is expected to provide efficient, adoptive immunotherapy against cancer. Soluble β-glucan maitake D-fraction, extracted from the maitake mushroom Grifola frondosa, acts as a potent immunotherapeutic agent, eliciting innate and adoptive immune responses, thereby contributing to its antitumor activity. Here, we evaluated the efficacy of maitake D-fraction, in combination with a Toll-like receptor agonist, to treat tumors in a murine model...
December 2015: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/26094138/ph-recycling-aqueous-two-phase-systems-applied-in-extraction-of-maitake-%C3%AE-glucan-and-mechanism-analysis-using-low-field-nuclear-magnetic-resonance
#10
Huiyun Hou, Xuejun Cao
In this paper, a recycling aqueous two-phase systems (ATPS) based on two pH-response copolymers PADB and PMDM were used in purification of β-Glucan from Grifola frondosa. The main parameters, such as polymer concentration, type and concentration of salt, extraction temperature and pH, were investigated to optimize partition conditions. The results demonstrated that β-Glucan was extracted into PADB-rich phase, while impurities were extracted into PMDM-rich phase. In this 2.5% PADB/2.5% PMDM ATPS, 7.489 partition coefficient and 96...
July 31, 2015: Journal of Chromatography. A
https://www.readbyqxmd.com/read/25351719/maitake-mushroom-extract-in-myelodysplastic-syndromes-mds-a-phase-ii-study
#11
Kathleen M Wesa, Susanna Cunningham-Rundles, Virginia M Klimek, Emily Vertosick, Marci I Coleton, K Simon Yeung, Hong Lin, Stephen Nimer, Barrie R Cassileth
BACKGROUND: Myelodysplastic syndromes (MDS) are characterized by ineffective erythropoiesis with dysplastic bone marrow leading to peripheral cytopenia, risk of infection, and progression to acute myelogenous leukemia. Maitake mushroom beta-glucan, a dietary supplement, stimulates hematopoietic progenitor cell differentiation, granulocyte colony-stimulating factor production, and recovery of peripheral blood leukocytes after bone marrow injury. This phase II trial examined the effects of Maitake on innate immune function in MDS...
February 2015: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/25332990/immune-enhancing-effects-of-maitake-grifola-frondosa-and-shiitake-lentinula-edodes-extracts
#12
Vaclav Vetvicka, Jana Vetvickova
BACKGROUND: The role of glucan in stimulation of immune reactions has been studied for several decades. In this report, we focused on the effects of orally administered glucan Maitake and Shiitake on immune reactions. MATERIALS AND METHODS: We measured phagocytosis, NK cell activity, and secretion of IL-6, IL-12, IFN-γ as well as C-reactive protein (CRP) after 14 days of oral application of tested glucans. For comparison, active hexose correlated compound (AHCC) was used in all reactions...
February 2014: Annals of Translational Medicine
https://www.readbyqxmd.com/read/24750630/hypoglycemic-and-hypolipidemic-activities-of-mt-%C3%AE-glucan-and-its-effect-on-immune-function-of-diabetic-mice
#13
Hong Lei, Shuzhen Guo, Juncheng Han, Qin Wang, Xiaoxiang Zhang, Wutong Wu
The hypoglycemic and hypolipidemic effect of an α-glucan (designed here as MT-α-glucan) from fruit body of maitake (Grifola frondosa) on diabetic mouse model induced by streptozotocin and high-fat-diet were evaluated, and its effect on immune function of diabetic mice was investigated. Treatment with MT-α-glucan (300 or 100 mg kg(-1)) could decrease the levels of fasting plasma glucose, triglycerides, cholesterol, free fatty acid, the proliferative response of macrophages and IL-1, NO production by macrophages significantly...
June 5, 2012: Carbohydrate Polymers
https://www.readbyqxmd.com/read/24430059/the-medicinal-value-of-the-mushroomgrifola
#14
S C Jong, J M Birmingham
This review contains the most recent information on the various substances isolated and Identified in the maitake mushroomGrifola, their source and significance. The majority of the references concern the anti-tumour polysaccharides that have been extracted from fruiting bodies and mycelia, but certain species can also act as metabolic regulators and contain enzymes, essential amino acids, lipids and vitamins. The use of edible fungi in the development and application of beneficial biological activities ofters an advantage in that the active principle is safe and can be tolerated by humans...
September 1990: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/24299767/extraction-preliminary-characterization-and-antioxidant-activity-of-se-enriched-maitake-polysaccharide
#15
Guanghua Mao, Ye Zou, Weiwei Feng, Wei Wang, Ting Zhao, Changwen Ye, Yang Zhu, Xueshan Wu, Liuqing Yang, Xiangyang Wu
A Se-enriched Grifola frondosa polysaccharide (Se-GP) was obtained from G. frondosa enriched with Se by spraying an Na2SeO3 solution during fruit body growth using a Box-Behnken design and compared to G. frondosa polysaccharide (GP) for preliminary characterization and determination of the antioxidant activity. Under optimal conditions, polysaccharide yields and both the Se-GP and GP contents do not differ; however, the Se content of Se-GP (17.52 μg/g) was 48.7 times that of GP. Three homogenous Se-GPs (Se-GP11, Se-GP22 and Se-GP33) or GPs (GP11, GP22 and GP33) were obtained via DEAE-52 and Sephacryl S-400 purification...
January 30, 2014: Carbohydrate Polymers
https://www.readbyqxmd.com/read/24292357/effect-of-dietary-maitake-grifola-frondosa-mushrooms-on-plasma-cholesterol-and-hepatic-gene-expression-in-cholesterol-fed-mice
#16
Mayumi Sato, Yoshihiko Tokuji, Shozo Yoneyama, Kyoko Fujii-Akiyama, Mikio Kinoshita, Hideyuki Chiji, Masao Ohnishi
To investigate the effects of dietary Grifola frondosa on cholesterol, normal mice were fed a diet containing 1% cholesterol (HC group) or 1% cholesterol and 10% freeze-dried G. frondosa powder (HC+G group) for 4 weeks and hepatic and plasma lipid levels were compared with those of a cholesterol-free diet-fed mice (N group). Hepatic total cholesterol (TC), triacylglycerol contents were considerably increased and plasma TC / phospholipid (PL) was also increased significantly in the HC group compared with the N group...
2013: Journal of Oleo Science
https://www.readbyqxmd.com/read/24020458/characterization-of-a-novel-maitake-grifola-frondosa-protein-that-activates-natural-killer-and-dendritic-cells-and-enhances-antitumor-immunity-in-mice
#17
Yao-Wei Tsao, Yen-Chou Kuan, Jia-Lin Wang, Fuu Sheu
Grifola frondosa, also known as maitake, is a culinary mushroom with immune-enhancing and antitumor effects. Numerous studies have investigated the activity of maitake polysaccharide extracts, but studies of maitake proteins are scarce. In this study, we purified and characterized a new G. frondosa protein, GFP, from maitake fruiting bodies. GFP is a nonglucan heterodimeric 83 kDa protein that consists of two 41 kDa subunits. GFP induced interferon-γ secretion by murine splenocytes and natural killer cells and activated the maturation of bone marrow-derived dendritic cells (BMDCs) via a TLR4-dependent mechanism...
October 16, 2013: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/23875900/genes-related-to-suppression-of-malignant-phenotype-induced-by-maitake-d-fraction-in-breast-cancer-cells
#18
Eliana Noelia Alonso, Manuela Orozco, Alvaro Eloy Nieto, Gabriela Andrea Balogh
It is already known that the Maitake (D-Fraction) mushroom is involved in stimulating the immune system and activating certain cells that attack cancer, including macrophages, T-cells, and natural killer cells. According to the U.S. National Cancer Institute, polysaccharide complexes present in Maitake mushrooms appear to have significant anticancer activity. However, the exact molecular mechanism of the Maitake antitumoral effect is still unclear. Previously, we have reported that Maitake (D-Fraction) induces apoptosis in breast cancer cells by activation of BCL2-antagonist/killer 1 (BAK1) gene expression...
July 2013: Journal of Medicinal Food
https://www.readbyqxmd.com/read/23796219/mt-%C3%AE-glucan-from-the-fruit-body-of-the-maitake-medicinal-mushroom-grifola-frondosa-higher-basidiomyetes-shows-protective-effects-for-hypoglycemic-pancreatic-%C3%AE-cells
#19
Hong Lei, Minmin Zhang, Qin Wang, Shuzhen Guo, Juncheng Han, Hanju Sun, Wutong Wu
The hypoglycemic effect of an α-glucan (designated here as MT-α-glucan) from the fruit body of the Maitake medicinal mushroom, Grifola frondosa, on a murine type 2 diabetes mellitus (T2DM) model was evaluated. Body weight and levels of fasting plasma glucose, glycosylated hemoglobin, triglycerides, cholesterol, free fatty acid, nitric oxide (NO), NO synthase, inducible NO synthase, and hepatic malondialdehyde content decreased significantly when MT-α-glucan was administered to T2DM mice. The content of serum insulin, hepatic glycogen, and reduced glutathione and the activity of superoxide dismutase and glutathione peroxidase increased significantly when MT-α-glucan was administered to T2DM mice...
2013: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/23557366/purification-and-characterization-of-a-novel-small-molecule-polysaccharide-from-the-maitake-medicinal-mushroom-grifola-frondosa-higher-basidiomycetes
#20
Changyan Zhou, Yanru Qiao, Qingjiu Tang, Wei Jia, Yanfang Liu, Aizhong Wu
A novel small-molecule polysaccharide with a molecular mass of 2.6 kDa, was isolated from the culinary-medicinal Maitake mushroom Grifola frondosa. GFPS is composed of fucose, rhamnose, galactose, glucose, and mannose; galactose, glucose, and mannose were the dominant monosaccharides. Absorption peaks at 1077 cm-1, 1024 cm-1, and 873 cm-1, as revealed by infrared spectrum, suggesting that GFPS consists of pyranoside. GFPS significantly enhanced the production of nitric oxide and secretion of cytokines (tumor necrosis factor-α, interleukin-1β, and interleukin-δ) from macrophages in vitro...
2013: International Journal of Medicinal Mushrooms
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