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S Kaul, J Zimmer, O Dehus, A Constanzo, A DaasConstanzo, K-H Buchheit, J Asturias, M C Arilla, D Barber, A Bertocchi, B Brunetto, J A Carnes, M Chapman, G Chaudemanche, J Dayan-Kenigsberg, S Döring, F Führer, M T Gallego, P Iacovacci, K M Hanschmann, T Holzhauser, M Hrabina, A Ledesma, P Moingeon, E Nony, C Pini, G Plunkett, M Raulf, G Reese, E Sandberg, I Sander, B Smith, D Strecker, C Valerio, R van Ree, B Weber, S Vieths
To date, the potency of allergen products in Europe is expressed in manufacturer-specific units relative to a product-specific in-house reference. Consequently, cross-product comparability of allergen products from different manufacturers with respect to strength and efficacy is impossible. The Biological Standardisation Programme (BSP) project BSP090 addresses this issue via the establishment of reference standards in conjunction with ELISA methods for the quantification of major allergens in allergen products...
2017: Pharmeuropa Bio & Scientific Notes
David Bell, Noni Gachuhi, Nassim Assefi
Most health care in low-income countries is delivered at a primary care level by health workers who lack quality training and supervision, often distant from more experienced support. Lack of knowledge and poor communication result in a poor quality of care and inefficient delivery of health services. Although bringing great benefits in sectors such as finance and telecommunication in recent years, the Digital Revolution has lightly and inconsistently affected the health sector. These advances offer an opportunity to dramatically transform health care by increasing the availability and timeliness of information to augment clinical decision-making, based on improved access to patient histories, current information on disease epidemiology, and improved incorporation of data from point-of-care and centralized diagnostic testing...
November 6, 2017: American Journal of Tropical Medicine and Hygiene
Noni E MacDonald, Philippe Duclos, Ole Wichmann, Louise Henaff, Anthony Harnden, Aisha Alshammary, Roberto Arroba Tijerino, Madeline Hall, Jahit Sacarlal, Rupa Rajbhandari Singh
National Immunization Technical Advisory Groups (NITAGs) provide independent, evidence-informed advice to assist their governments in immunization policy formation. This is complex work and many NITAGs face challenges in fulfilling their roles. Inter-country NITAG collaboration opportunities have the potential to enhance NITAG function and grow the quality of recommendations. Hence the many requests for formation of a network linking NITAGs together so they can learn from each other. The first Global NITAG Network (GNN) meeting, held in 2016, led to a push to launch the GNN and grow the network...
November 2, 2017: Vaccine
Noni Chan, Maria-Elisabeth Smet, Rhiannon Sandow, Fabricio da Silva Costa, Andrew McLennan
OBJECTIVE: To investigate the pregnancy outcomes in a cohort of women who failed to obtain a result in non-invasive prenatal testing (NIPT). DESIGN: Historical cohort study. SETTING: A multicenter private practice in Sydney, Australia. POPULATION: Women who failed to obtain a result from NIPT (n=131). METHODS: The maternal characteristics, antenatal investigations and pregnancy outcomes for these women were compared to those who obtained a result at the same practice and to the general Australian obstetric population...
November 1, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
Noni E MacDonald, Robb Butler, Eve Dubé
Addressing the drivers of vaccine hesitancy and the barriers to vaccine acceptance is a complex but important task. While the percentage of hesitant does vary from country to country and in time few, if any, countries are ever free from this problem. Overcoming hesitancy requires detection, diagnosis and tailored intervention as there is no simple strategy that can address all of the barriers to vaccine acceptance. Immunization program managers and health care workers need to become adept at recognizing and tackling hesitancy in all of its incarnations if high levels of vaccine acceptance are to be achieved but must also actively support immunization acceptors in order to build and support vaccine acceptance resiliency...
October 19, 2017: Human Vaccines & Immunotherapeutics
Noni K Gaylord-Harden, Grace J Bai, Dusan Simic
The purpose of the current study was to examine a dual-process model of reactivity to community violence exposure in African American male adolescents from urban communities. The model focused on desensitization and hypersensitization effects as well as desensitization and hypersensitization as predictors of aggressive behavior. Participants were 133 African American male high school students, mean age = 15.17 years, SD = 0.96. Participants completed measures of exposure to community violence, depressive symptoms, hyperarousal symptoms, aggressive beliefs, and aggressive behaviors at two time points...
October 2017: Journal of Traumatic Stress
Ivan M Taremwa, Scholastic Ashaba, Harriet O Adrama, Carlrona Ayebazibwe, Daniel Omoding, Imelda Kemeza, Jane Yatuha, Thadeus Turuho, Noni E MacDonald, Robert Hilliard
BACKGROUND: The burden of malaria in Uganda remains unacceptably high, especially among children and pregnant women. To prevent malaria related complications, household possession and use of Insecticide Treated mosquito Nets (ITNs) has become a common practice in the country. Despite the availability of ITNs, malaria remains a foremost public health concern in Uganda. We sought to explore knowledge, attitude, and behaviour towards the use of ITNs as a nightly malaria prevention strategy among pregnant women and children under five years of age in Isingiro district, Southwestern Uganda...
October 10, 2017: BMC Public Health
Catherine Cornu, Catherine Mercier, Tiphanie Ginhoux, Sandrine Masson, Julie Mouchet, Patrice Nony, Behrouz Kassai, Valérie Laudy, Patrick Berquin, Nathalie Franc, Marie-France Le Heuzey, Hugues Desombre, Olivier Revol
OBJECTIVE: Clinical trials and inconclusive meta-analyses have investigated the effects of omega-3 supplements in children with Attention-Deficit Hyperactivity Disorder (ADHD). We performed a randomised placebo-controlled trial to evaluate the efficacy of omega-3 fatty acids. METHODS: Children aged 6-15 years with established diagnosis of ADHD were randomised 1:1 to receive either supplements containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) or a placebo for 3 months...
October 5, 2017: European Child & Adolescent Psychiatry
Matteo Pernigo, Giovanni Benfari, Giulia Geremia, Manjola Noni, Gianluca Borio, Gloria Mazzali, Mauro Zamboni, Francesco Onorati, Giuseppe Faggian, Corrado Vassanelli, Andrea Rossi
BACKGROUND: Postoperative atrial fibrillation (POAF) is a common, clinically relevant, but hardly predictable complication after surgical aortic valve replacement. The aim of this study was to test the role of preoperative left atrial longitudinal strain as a predictor of POAF in clinical practice. METHODS: Sixty patients scheduled for aortic valve replacement for severe isolated aortic stenosis, in stable sinus rhythm, were prospectively enrolled and underwent full clinical, biochemical, and transthoracic echocardiographic assessment on the day before surgery...
October 2017: Journal of the American Society of Echocardiography
Véronique Bordas-Le Floch, Maxime Le Mignon, Laetitia Bussières, Karine Jain, Armelle Martelet, Véronique Baron-Bodo, Emmanuel Nony, Laurent Mascarell, Philippe Moingeon
BACKGROUND: House dust mites (HDMs) such as Dermatophagoides farinae and D. pteronyssinus represent major causes of perennial allergy. HDM proteomes are currently poorly characterized, with information mostly restricted to allergens. As of today, 33 distinct allergen groups have been identified for these 2 mite species, with groups 1 and 2 established as major allergens. Given the multiplicity of IgE-reactive mite proteins, potential additional allergens have likely been overlooked. OBJECTIVE: To perform a comprehensive characterization of the transcriptomes, proteomes and allergomes of D...
2017: PloS One
Hanna Gu, Kanitsak Boonanantanasarn, Moonkyu Kang, Ikhwi Kim, Kyung Mi Woo, Hyun-Mo Ryoo, Jeong-Hwa Baek
Morinda citrifolia (Noni) leaf is an herbal medicine with application in the domestic treatment of a broad range of conditions, including bone fracture and luxation. However, the basic mechanism underlying the stimulation of osteogenic differentiation by Noni leaf extract remains poorly understood. This study aimed to examine the effect of this extract on osteogenic differentiation and the mechanism by which Noni leaf extract enhances osteogenic differentiation. Aqueous extract of Noni leaves was prepared, and rutin and kaempferol-3-O-rutinoside were identified to be two of its major components...
October 5, 2017: Journal of Medicinal Food
Anees B Chagpar
Dedicated to the memory of Dr. William Hunter Harridge and Nonie Lowry, this manuscript discusses the ups and downs associated with novel therapies in breast cancer, and applies the lessons of persistence learned from baseball to our quest for more optimal treatments, particularly in triple negative breast cancer.
September 20, 2017: American Journal of Surgery
David Morakinyo Sanni, Toluwase Hezekiah Fatoki, Ayodele Oluseyi Kolawole, Afolabi Clement Akinmoladun
Morinda citrifolia (Noni) fruit has a long history of dietary use in tropical regions of the world. Pharmacological properties that have been attributed to the fruit include anti-inflammatory, anti-cancer, and antioxidant properties. Xeronine, a small alkaloid which has been patented (US4543212) is one of the bioactive compounds of Noni fruit, which is believed to be capable of modifying the molecular structure of specific inactive proteins thereby regulating proper folding to active enzymes. Despite reports of the potential of Xeronine as therapeutic agent, its presence is controversial and its structure has not been explored...
2017: In Silico Pharmacology
Alyssa Hidalgo, Anita Ferraretto, Ivano De Noni, Michela Bottani, Stefano Cattaneo, Simone Galli, Andrea Brandolini
Carotenoids, tocols, phenolic acids and antioxidant capacity were studied during in vitro digestion of water biscuits (WB) from bread wheat, einkorn and einkorn-pseudocereals. Antioxidant and cytotoxic activities of digestates were also measured using a 70% Caco2/30% HT-29 human intestinal co-culture layer. Antioxidant profiles differed among WB formulations. Only hydrophilic molecules were solubilised by gastric digestion. After intestinal digestion, 77% carotenoids and 67% tocols were released. Soluble-conjugated phenolic acids increased (30%) and insoluble-bound forms decreased (17%), suggesting partial conversion from bound to conjugated form...
February 1, 2018: Food Chemistry
Janaina Costa E Silva, Dalmarcia de Sousa Carlos Mourão, Fabia Silva de Oliveira Lima, Renato de Almeida Sarmento, Mateus Sunti Dalcin, Raimundo Wagner de Souza Aguiar, Gil Rodrigues Dos Santos
The objective of this work was to evaluate the efficiency of noni essential oil on the control of Exserohilum turcicum, a causative agent of Exserohilum spot in maize culture. In the sanitary test 400 seeds were incubated using the blotter test method. For the transmissibility test, the fragments of damaged leaves of seedlings were removed and put into a potato, dextrose and agar (PDA) culture environment. To verify the pathogenicity, Koch´s postulates were performed. In the phytotoxicity test different concentrations of noni oil were applied in maize seedlings...
August 14, 2017: Medicines (Basel, Switzerland)
Eugene Kouassi, Oluyele Akinkugbe, Noni Oratile Kutlo, J M Bosson Brou
This paper investigates the long run relationship between health care expenditure and economic growth, using panel data for 14 Southern African Development Community (SADC) member countries over the period 1995-2012. The non-stationarity and cointegration properties between health expenditure per capita and GDP per capita were examined, controlling for cross section dependence and heterogeneity between countries. Our results suggest that health expenditure and GDP per capita are non-stationary and cointegrated...
August 30, 2017: International Journal of Health Economics and Management
Oriane Marmontel, Mathilde Di Filippo, Christophe Marcais, Séverine Nony, Marjorie Dumoux, Marine Serveaux-Dancer, Cyrielle Caussy, Sybil Charrière, Philippe Moulin
BACKGROUND AND AIMS: The heterogeneity and mechanisms of multifactorial chylomicronemia (MCM) remain poorly understood. To gain new insights, post heparin lipolysis measured at 60 min (PHLA60), in addition to the more commonly used 10 min (PHLA10), was assessed in patients with history of MCM. METHODS: 62 consecutive MCM patients were studied. The evaluation included LPL, APOC2, APOA5, GPIHBP1, LMF1 and APOE gene sequencing, as well as pre- and post-heparin injection biochemical analysis, including lipid profiles, determination of apolipoprotein B, B-48, CII, CIII, lipoprotein lipase (LPL) concentrations (LPLC0, LPLC10 and LPLC60) and post-heparin LPL activity (PHLA10 and PHLA60)...
July 29, 2017: Atherosclerosis
Nurul Shamsinah Mohd Suhaimi, Share-Yuan Goh, Noni Ajam, Rofina Yasmin Othman, Kok-Gan Chan, Kwai Lin Thong
Banana is one of the most important fruits cultivated in Malaysia, and it provides many health benefits. However, bacterial wilt disease, which attacks bananas, inflicts major losses on the banana industry in Malaysia. To understand the complex interactions of the microbiota of bacterial wilt-diseased banana plants, we first determined the bacterial communities residing in the pseudostems of infected (symptomatic) and diseased-free (non-symptomatic) banana plants. We characterized the associated microorganisms using the targeted 16S rRNA metagenomics sequencing on the Illumina MiSeq platform...
August 21, 2017: World Journal of Microbiology & Biotechnology
Jeanie L Y Cheong, Peter J Anderson, Alice C Burnett, Gehan Roberts, Noni Davis, Leah Hickey, Elizabeth Carse, Lex W Doyle
BACKGROUND AND OBJECTIVE: Survival of extremely preterm (EP; <28 weeks' gestation) infants has increased over the last 2 decades. Equivalent reductions in developmental morbidity in early childhood have not been consistently reported. The aim of this study was to determine trends in neurodevelopmental outcomes at 8 years of age of children born EP (22-27 completed weeks' gestation) over the past 2 decades. METHODS: Population-based cohorts of all EP survivors born in the state of Victoria, Australia in 1991-1992, 1997, and 2005 were recruited at birth...
June 2017: Pediatrics
Nonie J Finlayson, Andriani Papageorgiou, D Samuel Schwarzkopf
How we perceive the environment is not stable and seamless. Recent studies found that how a person qualitatively experiences even simple visual stimuli varies dramatically across different locations in the visual field. Here we use a method we developed recently that we call multiple alternatives perceptual search (MAPS) for efficiently mapping such perceptual biases across several locations. This procedure reliably quantifies the spatial pattern of perceptual biases and also of uncertainty and choice. We show that these measurements are strongly correlated with those from traditional psychophysical methods and that exogenous attention can skew biases without affecting overall task performance...
August 1, 2017: Journal of Vision
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