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https://www.readbyqxmd.com/read/29770367/engaging-religious-leaders-to-support-hiv-prevention-and-care-for-gays-bisexual-men-and-other-men-who-have-sex-with-men-in-coastal-kenya
#1
Evans Gichuru, Bernadette Kombo, Noni Mumba, Salla Sariola, Eduard J Sanders, Elise M van der Elst
In Kenyan communities, religious leaders are important gatekeepers in matters of health and public morality. In a context that is generally homophobic, religious leaders may aggravate or reduce stigmatization of sexual minorities such as gay and bisexual men, and other men who have sex with men (GBMSM). Literature indicates mixed results in efforts to encourage religious leaders to work effectively and sensitively with issues regarding HIV and sexuality. This paper describes the implementation of an engagement intervention with religious leaders from different denominations, which took place following a homophobic hate attack that was led by local religious leaders, at an HIV research clinic for GBMSM on the Kenyan coast...
2018: Critical Public Health
https://www.readbyqxmd.com/read/29739780/research-priorities-in-health-communication-and-participation-international-survey-of-consumers-and-other-stakeholders
#2
Anneliese Synnot, Peter Bragge, Dianne Lowe, Jack S Nunn, Molly O'Sullivan, Lidia Horvat, Allison Tong, Debra Kay, Davina Ghersi, Steve McDonald, Naomi Poole, Noni Bourke, Natasha Lannin, Danny Vadasz, Sandy Oliver, Karen Carey, Sophie J Hill
OBJECTIVE: To identify research priorities of consumers and other stakeholders to inform Cochrane Reviews in 'health communication and participation' (including such concepts as patient experience, shared decision-making and health literacy). SETTING: International. PARTICIPANTS: We included anyone with an interest in health communication and participation. Up to 151 participants (18-80 years; 117 female) across 12 countries took part, including 48 consumers (patients, carers, consumer representatives) and 75 professionals (health professionals, policymakers, researchers) (plus 25 people who identified as both)...
May 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29736381/usage-biological-activity-and-safety-of-selected-botanical-dietary-supplements-consumed-in-the-united-states
#3
REVIEW
P Annécie Benatrehina, Li Pan, C Benjamin Naman, Jie Li, A Douglas Kinghorn
In view of the continuous growth of the botanical dietary supplement industry and the increased popularity of lesser known or exotic botanicals, recent findings are described on the phytochemical composition and biological activities of five selected fruits consumed in the United States, namely, açaí, noni, mangosteen, black chokeberry, and maqui berry. A review of the ethnomedicinal uses of these plants has revealed some similarities ranging from wound-healing to the treatment of fever and infectious diseases...
April 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29691190/noni-morinda-citrifolia-l-fruit-juice-delays-immunosenescence-in-the-lymphocytes-in-lymph-nodes-of-old-f344-rats
#4
Uday P Pratap, Hannah P Priyanka, Karthik R Ramanathan, Vishak Raman, Lalgi Hima, Srinivasan Thyagarajan
OBJECTIVE: Aging is associated with the development of diseases because of immunosuppression and altered functioning of the neuroendocrine system. The medicinal properties of Morinda citrifolia L. have been widely exploited for the treatment of age-associated diseases. This study aims to investigate the in vitro and in vivo effects of noni (M. citrifolia) fruit juice (NFJ) on neuro-immunomodulation in the lymph node lymphocytes of F344 rats. METHODS: Lymphocytes isolated from axillary and inguinal lymph nodes of young (3-4 months) and old (18-21 months) rats were treated in vitro with different concentrations (0...
April 12, 2018: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29625554/antiepileptic-drug-exposure-in-pregnancy-and-pregnancy-outcome-from-national-drug-usage-data
#5
Noni Richards, David Reith, Michael Stitely, Alesha Smith
BACKGROUND: Antiepileptic drugs (AEDs) are used by pregnant women to manage conditions such as epilepsy and bipolar disorder even though they pose a risk to the developing foetus. This study aimed to determine the overall use of AEDs by women during their childbearing years and women who are pregnant and the association between AED use and rates of pregnancy termination and spontaneous abortion. METHODS: Retrospective population based cohort study using administrative databases in New Zealand between 2008 and 2014...
April 6, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29615847/uncommon-egfr-mutations-in-cytological-specimens-of-1-874-newly-diagnosed-indonesian-lung-cancer-patients
#6
Elisna Syahruddin, Laksmi Wulandari, Nunuk Sri Muktiati, Ana Rima, Noni Soeroso, Sabrina Ermayanti, Michael Levi, Heriawaty Hidajat, Grace Widjajahakim, Ahmad Rusdan Handoyo Utomo
Purpose: We aimed to evaluate the distribution of individual epidermal growth factor receptor ( EGFR ) mutation subtypes found in routine cytological specimens. Patients and methods: A retrospective audit was performed on EGFR testing results of 1,874 consecutive cytological samples of newly diagnosed or treatment-naïve Indonesian lung cancer patients (years 2015-2016). Testing was performed by ISO15189 accredited central laboratory. Results: Overall test failure rate was 5...
2018: Lung Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29605516/vaccine-hesitancy-around-the-globe-analysis-of-three-years-of-who-unicef-joint-reporting-form-data-2015-2017
#7
Sarah Lane, Noni E MacDonald, Melanie Marti, Laure Dumolard
In order to gather a global picture of vaccine hesitancy and whether/how it is changing, an analysis was undertaken to review three years of data available as of June 2017 from the WHO/UNICEF Joint Report Form (JRF) to determine the reported rate of vaccine hesitancy across the globe, the cited reasons for hesitancy, if these varied by country income level and/or by WHO region and whether these reasons were based upon an assessment. The reported reasons were classified using the Strategic Advisory Group of Experts (SAGE) on Immunization matrix of hesitancy determinants (www...
March 28, 2018: Vaccine
https://www.readbyqxmd.com/read/29588992/are-doses-of-lamotrigine-or-levetiracetam-adjusted-during-pregnancy
#8
Noni Richards, David Reith, Michael Stitely, Alesha Smith
Subtherapeutic levels of lamotrigine and levetiracetam are more likely to occur during pregnancy owing to the effect of pregnancy on their pharmacokinetics. This can lead to suboptimal control of epilepsy, and guidelines recommend proactive dose adjustment in the second and third trimesters alongside therapeutic drug monitoring (TDM). This retrospective cohort study using administrative databases aimed to investigate whether prescribers adjust the dose of lamotrigine or levetiracetam during and after pregnancy and whether TDM is used to manage dose adjustment...
March 2018: Epilepsia Open
https://www.readbyqxmd.com/read/29580007/functional-characterization-of-lactobacillus-plantarum-item-17215-a-potential-biocontrol-agent-of-fungi-with-plant-growth-promoting-traits-able-to-enhance-the-nutritional-value-of-cereal-products
#9
Mattia Quattrini, Cristian Bernardi, Milda Stuknytė, Fabio Masotti, Alessandro Passera, Giovanni Ricci, Lisa Vallone, Ivano De Noni, Milena Brasca, Maria Grazia Fortina
In this work, we explored the potential of 25 Lactobacillus plantarum strains isolated from cereals and milk-based products, testing characteristics related to antifungal activity and to nutritional quality. The tested strains demonstrated interesting beneficial traits, such as the ability to utilize fructo-oligosaccharides, prebiotic substances that help probiotic microorganisms to grow in the human gut, and to reduce phytate, an antinutrient present in cereal sector. Regarding mould inhibition, we highlighted the ability of the strains to inhibit Penicillium roqueforti, Mucor circinelloides and mycotoxinogenic moulds associated with cereal grains as Aspergillus flavus, A...
April 2018: Food Research International
https://www.readbyqxmd.com/read/29577952/lipid-transfer-protein-isolated-from-noni-seeds-displays-antibacterial-activity-in-vitro-and-improves-survival-in-lethal-sepsis-induced-by-clp-in-mice
#10
Adson A Souza, Andrea S Costa, Dyély C O Campos, Andressa H M Batista, Gleilton W P Sales, Nádia A P Nogueira, Keila M M Alves, Andrelina Noronha Coelho-de-Souza, Hermógenes D Oliveira
In the present study, we aimed to evaluate the antibacterial activity of a lipid transfer protein isolated from Morinda citrifolia L. seeds, named McLTP1 , and to investigate its effect in the cecal ligation and puncture (CLP) mouse sepsis model. Antimicrobial assays revealed that McLTP1 (12.5-800 μg/mL) significantly reduced Staphylococcus aureus (ATCC 6538P and ATCC 14458) and Staphylococcus epidermidis (ATCC 12228) planktonic growth, reaching maximal inhibition of approximately 50% and 98%, respectively...
March 22, 2018: Biochimie
https://www.readbyqxmd.com/read/29576704/quantitative-determination-of-bioactive-constituents-in-noni-juice-by-high-performance-liquid-chromatography-with-electrospray-ionization-triple-quadrupole-mass-spectrometry
#11
Yongqiu Yan, Yu Lu, Shiping Jiang, Yu Jiang, Yingpeng Tong, Limin Zuo, Jun Yang, Feng Gong, Ling Zhang, Ping Wang
Background: Noni juice has been extensively used as folk medicine for the treatment of arthritis, infections, analgesic, colds, cancers, and diabetes by Polynesians for many years. Due to the lack of standard scientific evaluation methods, various kinds of commercial Noni juice with different quality and price were available on the market. Objective: To establish a sensitive, reliable, and accurate high-performance liquid chromatography with electrospray ionization triple quadrupole mass spectrometry (HPLC-ESI-MS/MS) method for separation, identification, and simultaneous quantitative analysis of bioactive constituents in Noni juice...
January 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29574980/blockade-of-the-renin-angiotensin-aldosterone-system-in-patients-with-arrhythmogenic-right-ventricular-dysplasia-a-double-blind-multicenter-prospective-randomized-genotype-driven-study-brave-study
#12
Elodie Morel, Ab Waheed Manati, Patrice Nony, Delphine Maucort-Boulch, Francis Bessière, Xu Cai, Timothee Besseyre des Horts, Alexandre Janin, Adrien Moreau, Phillippe Chevalier
Arrhythmogenic right ventricular dysplasia (ARVD) is a rare cardiomyopathy characterized by the progressive replacement of cardiomyocytes by fatty and fibrous tissue in the right ventricle (RV). These infiltrations lead to cardiac electrical instability and ventricular arrhythmia. Current treatment for ARVD is empirical and essentially based on treatment of arrhythmia. Thus, there is no validated treatment that will prevent the deterioration of RV function in patients with ARVD. The aim of the BRAVE study is to evaluate the effect of ramipril, an angiotensin-converting enzyme inhibitor, on ventricular myocardial remodeling and arrhythmia burden in patients with ARVD...
March 25, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29572815/single-short-in-del-and-copy-number-variations-detection-in-monogenic-dyslipidemia-using-an-ngs-strategy
#13
O Marmontel, S Charrière, T Simonet, V Bonnet, S Dumont, M Mahl, C Jacobs, S Nony, K Chabane, D Bozon, A Janin, N Peretti, A Lachaux, C Bardel, G Millat, P Moulin, C Marçais, M Di Filippo
Optimal molecular diagnosis of primary dyslipidemia is challenging to confirm the diagnosis, test and identify at risk relatives. The aim of this study was to test the application of a single targeted next-generation sequencing (NGS) panel for hypercholesterolemia, hypocholesterolemia, and hypertriglyceridemia molecular diagnosis. NGS workflow based on a custom AmpliSeq panel was designed for sequencing the most prevalent dyslipidemia causing genes (ANGPTL3, APOA5, APOC2, APOB, GPIHBP1, LDLR, LMF1, LPL, PCSK9) on the Ion PGM™ Sequencer...
March 23, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29507505/canada-s-eight-component-vaccine-safety-system-a-primer-for-health-care-workers
#14
Noni E MacDonald, Barbara J Law
Concerns about vaccine safety make some parents hesitant about immunization. Health care providers are pivotal in helping parents understand that Canada is a leader in vaccine safety. The present practice point provides an update on the eight components of Canada's vaccine safety system: (1) an evidence-based pre-license review and approval process; (2) strong regulations for manufacturers; (3) independent evidence-based vaccine use recommendations; (4) immunization competency training and standards for health care providers; (5) pharmacovigilance programs to detect and (6) determine causality of adverse events following immunization (AEFIs); (7) a program for vaccine safety and efficacy signal detection; and (8) the Canadian Immunization Research Network's special immunization clinics for children who have experienced serious AEFIs...
July 2017: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29487998/hyperthyrotropinemia-in-newly-diagnosed-cystic-fibrosis-patients-with-pancreatic-insufficiency-reversed-by-enzyme-therapy
#15
Aris Giannakopoulos, Anni Katelaris, Maria Noni, Theodore Karakonstantakis, Christina Kanaka-Gantenbein, Stavros Doudounakis
Patients with cystic fibrosis (CF) commonly present with an elevated TSH concentration, suggesting subclinical hypothyroidism. Its relation to concomitant pancreatic insufficiency and its natural course upon initiation of enzyme replacement have not been adequately studied. Herein, we investigated the thyroid function in newly diagnosed infants with CF and monitored the course of thyroid function response to pancreatic enzyme substitution treatment. Fourteen, newly diagnosed infants with CF and pancreatic insufficiency, were followed every 6-8 weeks for 6 months ensuing onset of pancreatic enzyme substitution therapy...
May 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29479287/les-infestations-par-les-poux-de-t%C3%A3%C2%AAte-une-mise-%C3%A3-jour-clinique
#16
Carl Cummings, Jane C Finlay, Noni E MacDonald
Les infestations par les poux de tête ( Pediculus humanus capitis ) ne constituent ni un risque sanitaire primaire ni un vecteur de maladie, mais représentent plutôt un problème de société au coût impor- tant. Pour diagnostiquer une infestation, il faut déceler un pou vivant. Même si les pyréthines et la perméthrine demeurent les traitements de première intention au Canada, la solution de myristate d'isopropyle et de ST-cyclométhicone et la diméticone peuvent être envisagées en deuxième intention après un échec thérapeutique démontré...
February 2018: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29479286/head-lice-infestations-a-clinical-update
#17
Carl Cummings, Jane C Finlay, Noni E MacDonald
Head lice ( Pediculus humanus capitis ) infestations are not a primary health hazard or a vector for disease, but they are a societal problem with substantial costs. Diagnosis of head lice infestation requires the detection of a living louse. Although pyrethrins and permethrin remain first-line treatments in Canada, isopropyl myristate/ST-cyclomethicone solution and dimeticone can be considered as second-line therapies when there is evidence of treatment failure.
February 2018: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29479236/the-next-vaccine-autism-question-are-school-aged-youth-with-autism-spectrum-disorder-undervaccinated-and-if-so-why
#18
Jillian H Filliter, Linda Dodds, Noni MacDonald, Sarah Shea, Eve Dubé, Isabel M Smith, Leslie Anne Campbell
Over the past two decades, the words 'autism' and 'vaccination' have often been linked and mired in controversy. In this commentary, we raise a different question about autism spectrum disorder (ASD) and vaccines: Are school-aged youth with ASD undervaccinated and, if so, why? There are several reasons why youth with ASD might be undervaccinated, including: belief in a vaccine-ASD link, challenges faced by youth with ASD when seeking health care and vaccine hesitancy factors that affect the general population...
August 2017: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29479223/le-syst%C3%A3-me-d-innocuit%C3%A3-vaccinale-canadien-en-huit-%C3%A3-tapes-des-notions-pour-les-travailleurs-de-la-sant%C3%A3
#19
Noni E MacDonald, Barbara J Law
Parce qu'ils s'inquiètent de l'innocuité vaccinale, certains parents hésitent à faire vacciner leurs enfants. Les professionnels de la santé jouent un rôle déterminant auprès des parents pour leur faire comprendre que le Canada est un chef de file en matière d'innocuité vaccinale. Le présent point de pratique fournit une mise à jour des huit étapes du système d'innocuité vaccinale canadien : 1) une analyse pré-homologation et un processus d'approbation fondés sur des données probantes; 2) une réglementation rigoureuse pour les fabricants; 3) des recommandations indépendantes et fondées sur des données probantes à l'égard de l'utilisation des vaccins; 4) la formation et les normes sur les compétences en matière d'immunisation pour les travailleurs de la santé; 5) des programmes de pharmacovigilance pour déceler et 6) déterminer la causalité des effets secondaires suivant l'immunisation (ESSI); 7) un programme pour la détection des signaux relatifs à l'innocuité et à l'efficacité vaccinales; et 8) les cliniques de vaccination spéciales du Réseau de recherche canadien sur l'immunisation pour les enfants qui ont été victimes de graves ESSI...
July 2017: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29479221/le-syst%C3%A3-me-d-innocuit%C3%A3-vaccinale-canadien-en-huit-%C3%A3-tapes-des-notions-pour-les-travailleurs-de-la-sant%C3%A3
#20
Noni E MacDonald, Barbara J Law
Parce qu'ils s'inquiètent de l'innocuité vaccinale, certains parents hésitent à faire vacciner leurs enfants. Les professionnels de la santé jouent un rôle déterminant auprès des parents pour leur faire comprendre que le Canada est un chef de file en matière d'innocuité vaccinale. Le présent point de pratique fournit une mise à jour des huit étapes du système d'innocuité vaccinale canadien : 1) une analyse pré-homologation et un processus d'approbation fondés sur des données probantes; 2) une réglementation rigoureuse pour les fabricants; 3) des recommandations indépendantes et fondées sur des données probantes à l'égard de l'utilisation des vaccins; 4) la formation et les normes sur les compétences en matière d'immunisation pour les travailleurs de la santé; 5) des programmes de pharmacovigilance pour déceler et 6) déterminer la causalité des effets secondaires suivant l'immunisation (ESSI); 7) un programme pour la détection des signaux relatifs à l'innocuité et à l'efficacité vaccinales; et 8) les cliniques de vaccination spéciales du Réseau de recherche canadien sur l'immunisation pour les enfants qui ont été victimes de graves ESSI...
July 2017: Paediatrics & Child Health
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