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https://www.readbyqxmd.com/read/27908549/noni-leaf-and-black-tea-enhance-bone-regeneration-in-estrogen-deficient-rats
#1
Nor Aijratul Asikin Mohd Shalan, Noordin M Mustapha, Suhaila Mohamed
OBJECTIVE: Black tea and Nonileaf are among the dietary compounds that can benefit patients with bone resorption disorders. Their bone regeneration effects and their mechanisms were studied in estrogen-deficient rats. METHODS: Noni leaves (three doses) and black tea water extracts were fed to ovariectomized rats for 4 mo, and their effects (analyzed via mechanical measurements, micro-computed tomography scan, and reverse transcriptase polymerase chain reaction mRNA) were compared with Remifemin (a commercial phytoestrogen product from black cohosh)...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27871867/chronic-toxicity-evaluation-of-morinda-citrifolia-fruit-and-leaf-in-mice
#2
Nor Aijratul Asikin Mohamad Shalan, Noordin M Mustapha, Suhaila Mohamed
Noni (Morinda citrifolia) leaf and fruit are used as food and medicine. This report compares the chronic toxicity of Noni fruit and edible leaf water extracts (two doses each) in female mice. The 6 months study showed the fruit extract produced chronic toxicity effects at the high dose of 2 mg/ml drinking water, evidenced through deteriorated liver histology (hepatocyte necrosis), reduced liver length, increased liver injury marker AST (aspartate aminotransferase) and albumin reduction, injury symptoms (hypoactivity, excessive grooming, sunken eyes and hunched posture) and 40% mortality within 3 months...
November 18, 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27868087/diabetic-wound-healing-and-activation-of-nrf2-by-herbal-medicine
#3
Donald R Senger, Shugeng Cao
Nrf2 defense is a very important cellular mechanism to control oxidative stress, which is implicated in wound healing. Nrf2 can induce many cytoprotective genes, including HO-1, NQO1 and G6PD. Among many natural products that have been reported as Nrf2 activators, sulforaphane and curcumin have been studied more widely than any others, and both are in clinical trials for non-cancerous disorders. Recently, we reported 4-ethyl catechol and 4-vinyl catechol as Nrf2 co-factors that can induce Nrf2 as potently as sulforaphane and curcumin...
2016: Journal of Nature and Science
https://www.readbyqxmd.com/read/27863131/conditions-of-microvessel-occlusion-for-blood-coagulation-in-flow
#4
A Bouchnita, T Galochkina, P Kurbatova, P Nony, V Volpert
Vessel occlusion is a perturbation of blood flow inside a blood vessel because of the fibrin clot formation. As a result, blood circulation in the vessel can be slowed down or even stopped. This can provoke the risk of cardiovascular events. In order to explore this phenomenon, we used a previously developed mathematical model of blood clotting to describe the concentrations of blood factors with a reaction-diffusion system of equations. The Navier-Stokes equations were used to model blood flow and we treated the clot as a porous medium...
November 10, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27816491/the-noni-anthraquinone-damnacanthal-is-a-multi-kinase-inhibitor-with-potent-anti-angiogenic-effects
#5
Javier A García-Vilas, Almudena Pino-Ángeles, Beatriz Martínez-Poveda, Ana R Quesada, Miguel Ángel Medina
The natural bioactive compound damnacanthal inhibits several tyrosine kinases. Herein, we show that -in fact- damancanthal is a multi kinase inhibitor. A docking and molecular dynamics simulation approach allows getting further insight on the inhibitory effect of damnacanthal on three different kinases: vascular endothelial growth factor receptor-2, c-Met and focal adhesion kinase. Several of the kinases targeted and inhibited by damnacanthal are involved in angiogenesis. Ex vivo and in vivo experiments clearly demonstrate that, indeed, damnacanthal is a very potent inhibitor of angiogenesis...
November 2, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27799291/niacin-mediated-tace-activation-ameliorates-cmt-neuropathies-with-focal-hypermyelination
#6
Alessandra Bolino, Françoise Piguet, Valeria Alberizzi, Marta Pellegatta, Cristina Rivellini, Marta Guerrero-Valero, Roberta Noseda, Chiara Brombin, Alessandro Nonis, Patrizia D'Adamo, Carla Taveggia, Stefano Carlo Previtali
Charcot-Marie-Tooth (CMT) neuropathies are highly heterogeneous disorders caused by mutations in more than 70 genes, with no available treatment. Thus, it is difficult to envisage a single suitable treatment for all pathogenetic mechanisms. Axonal Neuregulin 1 (Nrg1) type III drives Schwann cell myelination and determines myelin thickness by ErbB2/B3-PI3K-Akt signaling pathway activation. Nrg1 type III is inhibited by the α-secretase Tace, which negatively regulates PNS myelination. We hypothesized that modulation of Nrg1 levels and/or secretase activity may constitute a unifying treatment strategy for CMT neuropathies with focal hypermyelination as it could restore normal levels of myelination...
December 1, 2016: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/27784657/maternal-influenza-immunization-and-adverse-birth-outcomes-using-data-and-practice-to-inform-theory-and-research-design
#7
REVIEW
Varun K Phadke, Mark C Steinhoff, Saad B Omer, Noni E MacDonald
Maternal influenza immunization can reduce influenza-attributable morbidity and mortality among pregnant women and infants who are too young to be vaccinated. Data from empirical studies also support the hypothesis that immunization can protect the fetus against adverse outcomes if the mother is exposed to influenza. In their theoretical analysis in the Journal, Hutcheon et al. (Am J Epidemiol 2016;184(3):227-232) critiqued the existing evidence of the fetal benefits of maternal influenza immunization by calculating the sample sizes needed to demonstrate hypothetical reductions in risk and concluded that the benefits observed in empirical studies are likely implausible...
December 1, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27765646/relationship-of-childhood-adversity-and-neighborhood-violence-to-a-proinflammatory-phenotype-in-emerging-adult-african-american-men-an-epigenetic-link
#8
Linda Witek Janusek, Dina Tell, Noni Gaylord-Harden, Herbert L Mathews
African American men (AAM) who are exposed to trauma and adversity during their early life are at greater risk for poor health over their lifespan. Exposure to adversity during critical developmental windows may embed an epigenetic signature that alters expression of genes that regulate stress response systems, including those genes that regulate the inflammatory response to stress. Such an epigenetic signature may increase risk for diseases exacerbated by inflammation, and may contribute to health disparity...
October 17, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27760029/antioxidant-and-anti-inflammatory-activities-of-a-commercial-noni-juice-revealed-by-carrageenan-induced-paw-edema
#9
N Yilmazer, C Coskun, E Gurel-Gurevin, I Yaylim, E H Eraltan, E I Ikitimur-Armutak
This study aimed to investigate antioxidant and anti-inflammatory activities of a commercial product of noni (Morinda citrifolia) juice. Carrageenan-induced rat paw edema was employed as inflammatory model. One control and three experimental groups were formed. Experimental groups were administered noni juice alone, noni juice+carrageenan, and carrageenan alone. Oxidant and antioxidant capacity were determined by d-ROMs test and BAP test, respectively. Plasma concentrations of endothelin-1 and leptin were measured by ELISA...
September 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/27745953/commentary-to-how-to-respond-to-vocal-vaccine-deniers-in-public
#10
Philipp Schmid, Noni E MacDonald, Katrine Habersaat, Robb Butler
No abstract text is available yet for this article.
October 13, 2016: Vaccine
https://www.readbyqxmd.com/read/27729866/methanolic-extract-of-morinda-citrifolia-l-noni-unripe-fruit-attenuates-ethanol-induced-conditioned-place-preferences-in-mice
#11
Yasmin Khan, Vijayapandi Pandy
Phytotherapy is an emerging field successfully utilized to treat various chronic diseases including alcohol dependence. In the present study, we examined the effect of the standardized methanolic extract of Morinda citrifolia Linn. unripe fruit (MMC), on compulsive ethanol-seeking behavior using the mouse conditioned place preference (CPP) test. CPP was established by injections of ethanol (2 g/kg, i.p.) in a 12-day conditioning schedule in mice. The effect of MMC and the reference drug, acamprosate (ACAM), on the reinforcing properties of ethanol in mice was studied by the oral administration of MMC (1, 3, and 5 g/kg) and ACAM (300 mg/kg) 60 min prior to the final CPP test postconditioning...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27664661/protein-breakdown-and-release-of-%C3%AE-casomorphins-during-in-vitro-gastro-intestinal-digestion-of-sterilised-model-systems-of-liquid-infant-formula
#12
Stefano Cattaneo, Milda Stuknytė, Fabio Masotti, Ivano De Noni
Protein modifications occurring during sterilisation of infant formulas can affect protein digestibility and release of bioactive peptides. The effect of glycation and cross-linking on protein breakdown and release of β-casomorphins was evaluated during in vitro gastro-intestinal digestion (GID) of six sterilised model systems of infant formula. Protein degradation during in vitro GID was evaluated by SDS-PAGE and by measuring the nitrogen content of ultrafiltration (3kDa) permeates before and after in vitro GID of model IFs...
February 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27601432/increasing-airway-obstruction-from-8-to-18%C3%A2-years-in-extremely-preterm-low-birthweight-survivors-born-in-the-surfactant-era
#13
Lex W Doyle, Anne-Marie Adams, Colin Robertson, Sarath Ranganathan, Noni M Davis, Katherine J Lee, Jeanie L Cheong
BACKGROUND: The evolution of airway obstruction into late adolescence of extremely preterm (gestational age <28 weeks) or extremely low-birthweight (birth weight <1000 g) survivors in the era after surfactant was introduced is unclear. OBJECTIVE: To compare changes in spirometry from 8 to 18 years of age of a geographical cohort of preterm survivors with normal birth weight controls, and to determine higher risk groups within the preterm cohort. METHODS: Of 297 extremely preterm/low-birthweight survivors born in 1991-1992 in the state of Victoria, Australia, 81% and 70% had spirometry at 8 and 18 years of age, respectively...
September 6, 2016: Thorax
https://www.readbyqxmd.com/read/27587353/risk-and-protective-factors-in-early-child-development-results-from-the-all-our-babies-aob-pregnancy-cohort
#14
Sheila McDonald, Heather Kehler, Hamideh Bayrampour, Nonie Fraser-Lee, Suzanne Tough
BACKGROUND: Understanding factors that protect against early developmental delay among children who are experiencing adversity can inform prevention and early intervention strategies. AIMS: To identify risk factors for development delay at one year and protective factors for developmental delay in 'at risk' environments (poor maternal mental health and socio-demographic risk). METHODS AND PROCEDURES: Data was analyzed from 3360 mother-child dyads who participated in the All Our Babies (AOB) pregnancy cohort...
November 2016: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/27585435/nutritional-supplements-modulate-fluorescent-protein-bound-advanced-glycation-endproducts-and-digestive-enzymes-related-to-type-2-diabetes-mellitus
#15
Emily R Koch, Permal Deo
BACKGROUND: Chronic hyperglycemia enhances the formation of advanced glycation endproducts (AGEs) and reactive oxygen species (ROS), contributing to diabetic complications. Thus, controlling blood glucose levels, inhibiting the formation of AGEs and reducing ROS are key therapeutic targets in early stage type 2 diabetes. METHODS: The inhibitory effects of seven commercial liquid nutritional supplements against carbohydrate hydrolysing enzymes, α-amylase and α-glucosidase, was determined by dinitrosalicylic (DNS) reagent and p-nitrophenyl-α-D-glucopyranoside solution, respectively...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27579922/morinda-citrifolia-linn-reduces-parasite-load-and-modulates-cytokines-and-extracellular-matrix-proteins-in-c57bl-6-mice-infected-with-leishmania-leishmania-amazonensis
#16
Fernando Almeida-Souza, Flávia de Oliveira Cardoso, Bruno Vinicius da Conceição Souza, Tânia Zaverucha do Valle, Joicy Cortez de Sá, Iara Dos Santos da Silva Oliveira, Celeste da Silva Freitas de Souza, Carla Junqueira Moragas Tellis, Maria do Socorro Dos Santos Chagas, Maria Dutra Behrens, Ana Lúcia Abreu-Silva, Kátia da Silva Calabrese
The absence of an effective vaccine and the debilitating chemotherapy for Leishmaniasis demonstrate the need for developing alternative treatments. Several studies conducted with Morinda citrifolia have shown various biological activities, including antileishmanial activity, however its mechanisms of action are unknown. This study aimed to analyze the in vivo activity of M. citrifolia fruit juice (Noni) against Leishmania (Leishmania) amazonensis in C57BL/6 mice. M. citrifolia fruit juice from the Brazilian Amazon has shown the same constitution of other juices produced around the world and liquid chromatography-mass spectrometry analysis identified five compounds: deacetylasperulosidic acid, asperulosidic acid, rutin, nonioside B and nonioside C...
August 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27572713/assessment-of-the-role-of-noni-morinda-citrifolia-juice-for-inducing-osteoblast-differentiation-in-isolated-rat-bone-marrow-derived-mesenchymal-stem-cells
#17
Sharmila Hussain, Ramasamy Tamizhselvi, Leema George, Venkatraman Manickam
Background and Objectives: Morinda citrifolia (Noni), an important traditional medicinal plant still used in patients with bone fractures or dislocation to promote connective tissue repair and to reduce inflammation. However, the effects of Noni on bone metabolism and whether it influences the osteogenic differentiation is yet to be clarified. In this study, we investigated the effect of Morinda citrifolia (Noni) juice on the proliferation rate of rat bone marrow derived mesenchymal stem cells (BMSC) and the osteoblastic differentiation as shown by alkaline phosphatase (ALP), Runt-related transcription factor 2 (Runx2) and osteocalcin (OCN) mRNA expression in vitro...
November 30, 2016: International Journal of Stem Cells
https://www.readbyqxmd.com/read/27560369/drosophila-yakuba-mayottensis-a-new-model-for-the-study-of-incipient-ecological-speciation
#18
Amir Yassin
A full understanding of how ecological factors drive the fixation of genetic changes during speciation is obscured by the lack of appropriate models with clear natural history and powerful genetic toolkits. In a recent study, we described an early stage of ecological speciation in a population of the generalist species Drosophila yakuba (melanogaster subgroup) on the island of Mayotte (Indian Ocean). On this island, flies are strongly associated with the toxic fruits of noni (Morinda citrifolia) and show a partial degree of pre-zygotic reproductive isolation...
August 11, 2016: Fly
https://www.readbyqxmd.com/read/27552359/bio-inspired-design-and-oriented-synthesis-of-immunogenic-site-specifically-penicilloylated-peptides
#19
Noémie Scornet, Sandrine Delarue-Cochin, Marie-Eliane Azoury, Maxime Le Mignon, Julie-Anne Chemelle, Emmanuel Nony, Bernard Maillere, Raphael Terreux, Marc Pallardy, Delphine Joseph
β-Lactam antibiotics allergy is recognized as a public health concern. By covalently binding to serum proteins, penicillins are known to form immunogenic complexes. The latter are recognized and digested by antigen-presenting cells into drug-hapten peptides leading to the immunization of treated persons and IgE-mediated hypersensitivity reactions encompassing anaphylaxis. If type I allergic reactions to drugs are often unpredictable, they are known to be dependent on CD4+ T-cells. This fundamental study revisits the chemical basis of the benzylpenicillin (BP) allergy with the aim of identifying immunologically relevant biomimetic benzylpenicilloylated peptides through the analysis of BP-conjugated human serum albumin (BP-HSA) profile and the evaluation of the naïve CD4+ T-cell responses to candidate BP-HSA-derived peptides...
August 23, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27534655/proteomics-for-allergy-from-proteins-to-the-patients
#20
REVIEW
Emmanuel Nony, Maxime Le Mignon, Sébastien Brier, Armelle Martelet, Philippe Moingeon
Proteomics encompasses a variety of approaches unraveling both the structural features, post-translational modifications, and abundance of proteins. As of today, proteomic studies have shed light on the primary structure of about 850 allergens, enabling the design of microarrays for improved molecular diagnosis. Proteomic methods including mass spectrometry allow as well to investigate protein-protein interactions, thus yielding precise information on critical epitopes on the surface of allergens. Mass spectrometry is now being applied to the unambiguous identification, characterization, and comprehensive quantification of allergens in a variety of matrices, as diverse as food samples and allergen immunotherapy drug products...
September 2016: Current Allergy and Asthma Reports
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