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https://www.readbyqxmd.com/read/28194046/morinda-citrifolia-noni-fruit-juice-reduces-inflammatory-cytokines-expression-and-contributes-to-the-maintenance-of-intestinal-mucosal-integrity-in-dss-experimental-colitis
#1
Beatriz Coutinho de Sousa, Juliana Reis Machado, Marcos Vinicius da Silva, Thiago Alvares da Costa, Javier Emilio Lazo-Chica, Thatiane do Prado Degasperi, Virmondes Rodrigues Junior, Helioswilton Sales-Campos, Elizabeth Uber Bucek, Carlo José Freire Oliveira
Morinda citrifolia L. (noni) has been shown to treat different disorders. However, data concerning its role in the treatment of intestinal inflammation still require clarification. In the current study, we investigated the effects of noni fruit juice (NFJ) in the treatment of C57BL/6 mice, which were continuously exposed to dextran sulfate sodium (DSS) for 9 consecutive days. NFJ consumption had no impact on the reduction of the clinical signs of the disease or on weight loss. Nonetheless, when a dilution of 1 : 10 was used, the intestinal architecture of the mice was preserved, accompanied by a reduction in the inflammatory infiltrate...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28111215/noni-morinda-citrifolia-l-fruit-juice-reverses-age-related-decline-in-neural-immune-interactions-in-the-spleens-of-old-f344-rats
#2
Uday P Pratap, Lalgi Hima, Hannah P Priyanka, Srinivasan ThyagaRajan
ETHNOPHARMACOLOGICAL RELEVANCE: Various parts of the tropical plant, Morinda citrifolia L. (Noni), have been widely used in traditional medicine in South and Southeast Asia for several centuries. The therapeutic effects of the noni are believed to be mediated through several phytochemicals such as anthraquinones, iridoid, fatty acid glycosides, alcohols, etc. AIM OF THE STUDY: The aim of the study is to investigate the effects of Morinda citrifolia fruit juice (noni fruit juice; NFJ) on neural-immune interactions through the involvement of intracellular signaling pathways both in vitro and in vivo in the splenic lymphocytes of young and old male F344 rats...
January 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28041724/composition-proteolysis-and-volatile-profile-of-strachitunt-cheese
#3
F Masotti, S Cattaneo, M Stuknytė, G Battelli, L Vallone, I De Noni
Strachitunt, a blue-veined Italian cheese, received the Protected Designation of Origin (PDO) label in 2014. Its unique technological feature is represented by the dual-curd method of production. Strachitunt is produced from raw bovine milk with or without the inoculation of natural starter cultures of lactic acid bacteria, and the addition of secondary cultures of mold spores is not permitted by the product specification. Physico-chemical properties, proteolysis, and volatile profile of Strachitunt were investigated in 10 cheese samples (ripened for 75 d) made throughout spring 2015 and provided by the main cheese maker...
December 29, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/28039760/differential-patterns-of-2d-location-versus-depth-decoding-along-the-visual-hierarchy
#4
Nonie J Finlayson, Xiaoli Zhang, Julie D Golomb
Visual information is initially represented as 2D images on the retina, but our brains are able to transform this input to perceive our rich 3D environment. While many studies have explored 2D spatial representations or depth perception in isolation, it remains unknown if or how these processes interact in human visual cortex. Here we used functional MRI and multi-voxel pattern analysis to investigate the relationship between 2D location and position-in-depth information. We stimulated different 3D locations in a blocked design: each location was defined by horizontal, vertical, and depth position...
February 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/28026720/knowledge-and-practices-of-village-health-team-members-in-early-detection-and-care-for-children-with-severe-acute-malnutrition-at-the-community-level-a-case-study-in-rural-uganda
#5
Elizabeth Kemigisha, Daniel Atwine, Patrick Orikiriza, Naome Natukunda, Noni E MacDonald
No abstract available.
December 27, 2016: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/27977283/examining-the-effects-of-emotional-and-cognitive-desensitization-to-community-violence-exposure-in-male-adolescents-of-color
#6
Noni K Gaylord-Harden, Suzanna So, Grace J Bai, Patrick H Tolan
The current study examined pathways in a model of desensitization, the Pathologic Adaptation Model, in adolescent males of color. Specifically, the current study examined depressive symptoms and deviant beliefs as mediators of the association between community violence exposure and subsequent violent behavior. The current study included 250 African-American (67%) and Latino (33%) male adolescents (T1 mean age = 15.32) from the Chicago Youth Development Study. Consistent with the Pathologic Adaptation Model, results demonstrated that depressive symptoms mediated the association between the quadratic violence exposure term in middle adolescence and violent behaviors in late adolescence, but the direction of the mediation effect was dependent upon the levels of violence exposure in middle adolescence...
December 15, 2016: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/27965111/sialylated-fetuin-a-as-a-candidate-predictive-biomarker-for-successful-grass-pollen-allergen-immunotherapy
#7
Noémie Caillot, Julien Bouley, Karine Jain, Sandrine Mariano, Sonia Luce, Stéphane Horiot, Sabi Airouche, Chloé Beuraud, Christian Beauvallet, Philippe Devillier, Sylvie Chollet-Martin, Christine Kellenberger, Laurent Mascarell, Henri Chabre, Thierry Batard, Emmanuel Nony, Vincent Lombardi, Véronique Baron-Bodo, Philippe Moingeon
BACKGROUND: Eligibility to immunotherapy is based on the determination of IgE reactivity to a specific allergen by skin prick or in vitro testing. Biomarkers predicting the likelihood of clinical improvement during immunotherapy would significantly improve patient selection. METHODS: Proteins were differentially assessed by 2D-DiGE and label-free mass spectrometry in pre-treatment sera obtained from clinical responders and non-responders within a cohort of 82 grass pollen allergic patients receiving sublingual immunotherapy or placebo...
December 10, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27908549/noni-leaf-and-black-tea-enhance-bone-regeneration-in-estrogen-deficient-rats
#8
Nor Aijratul Asikin Mohd Shalan, Noordin M Mustapha, Suhaila Mohamed
OBJECTIVE: Black tea and Nonileaf are among the dietary compounds that can benefit patients with bone resorption disorders. Their bone regeneration effects and their mechanisms were studied in estrogen-deficient rats. METHODS: Noni leaves (three doses) and black tea water extracts were fed to ovariectomized rats for 4 mo, and their effects (analyzed via mechanical measurements, micro-computed tomography scan, and reverse transcriptase polymerase chain reaction mRNA) were compared with Remifemin (a commercial phytoestrogen product from black cohosh)...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27871867/chronic-toxicity-evaluation-of-morinda-citrifolia-fruit-and-leaf-in-mice
#9
Nor Aijratul Asikin Mohamad Shalan, Noordin M Mustapha, Suhaila Mohamed
Noni (Morinda citrifolia) leaf and fruit are used as food and medicine. This report compares the chronic toxicity of Noni fruit and edible leaf water extracts (two doses each) in female mice. The 6 months study showed the fruit extract produced chronic toxicity effects at the high dose of 2 mg/ml drinking water, evidenced through deteriorated liver histology (hepatocyte necrosis), reduced liver length, increased liver injury marker AST (aspartate aminotransferase) and albumin reduction, injury symptoms (hypoactivity, excessive grooming, sunken eyes and hunched posture) and 40% mortality within 3 months...
February 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27868087/diabetic-wound-healing-and-activation-of-nrf2-by-herbal-medicine
#10
Donald R Senger, Shugeng Cao
Nrf2 defense is a very important cellular mechanism to control oxidative stress, which is implicated in wound healing. Nrf2 can induce many cytoprotective genes, including HO-1, NQO1 and G6PD. Among many natural products that have been reported as Nrf2 activators, sulforaphane and curcumin have been studied more widely than any others, and both are in clinical trials for non-cancerous disorders. Recently, we reported 4-ethyl catechol and 4-vinyl catechol as Nrf2 co-factors that can induce Nrf2 as potently as sulforaphane and curcumin...
2016: Journal of Nature and Science
https://www.readbyqxmd.com/read/27863131/conditions-of-microvessel-occlusion-for-blood-coagulation-in-flow
#11
A Bouchnita, T Galochkina, P Kurbatova, P Nony, V Volpert
Vessel occlusion is a perturbation of blood flow inside a blood vessel because of the fibrin clot formation. As a result, blood circulation in the vessel can be slowed down or even stopped. This can provoke the risk of cardiovascular events. In order to explore this phenomenon, we used a previously developed mathematical model of blood clotting to describe the concentrations of blood factors with a reaction-diffusion system of equations. The Navier-Stokes equations were used to model blood flow and we treated the clot as a porous medium...
November 10, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27816491/the-noni-anthraquinone-damnacanthal-is-a-multi-kinase-inhibitor-with-potent-anti-angiogenic-effects
#12
Javier A García-Vilas, Almudena Pino-Ángeles, Beatriz Martínez-Poveda, Ana R Quesada, Miguel Ángel Medina
The natural bioactive compound damnacanthal inhibits several tyrosine kinases. Herein, we show that -in fact- damancanthal is a multi kinase inhibitor. A docking and molecular dynamics simulation approach allows getting further insight on the inhibitory effect of damnacanthal on three different kinases: vascular endothelial growth factor receptor-2, c-Met and focal adhesion kinase. Several of the kinases targeted and inhibited by damnacanthal are involved in angiogenesis. Ex vivo and in vivo experiments clearly demonstrate that, indeed, damnacanthal is a very potent inhibitor of angiogenesis...
January 28, 2017: Cancer Letters
https://www.readbyqxmd.com/read/27799291/niacin-mediated-tace-activation-ameliorates-cmt-neuropathies-with-focal-hypermyelination
#13
Alessandra Bolino, Françoise Piguet, Valeria Alberizzi, Marta Pellegatta, Cristina Rivellini, Marta Guerrero-Valero, Roberta Noseda, Chiara Brombin, Alessandro Nonis, Patrizia D'Adamo, Carla Taveggia, Stefano Carlo Previtali
Charcot-Marie-Tooth (CMT) neuropathies are highly heterogeneous disorders caused by mutations in more than 70 genes, with no available treatment. Thus, it is difficult to envisage a single suitable treatment for all pathogenetic mechanisms. Axonal Neuregulin 1 (Nrg1) type III drives Schwann cell myelination and determines myelin thickness by ErbB2/B3-PI3K-Akt signaling pathway activation. Nrg1 type III is inhibited by the α-secretase Tace, which negatively regulates PNS myelination. We hypothesized that modulation of Nrg1 levels and/or secretase activity may constitute a unifying treatment strategy for CMT neuropathies with focal hypermyelination as it could restore normal levels of myelination...
December 1, 2016: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/27784657/maternal-influenza-immunization-and-adverse-birth-outcomes-using-data-and-practice-to-inform-theory-and-research-design
#14
REVIEW
Varun K Phadke, Mark C Steinhoff, Saad B Omer, Noni E MacDonald
Maternal influenza immunization can reduce influenza-attributable morbidity and mortality among pregnant women and infants who are too young to be vaccinated. Data from empirical studies also support the hypothesis that immunization can protect the fetus against adverse outcomes if the mother is exposed to influenza. In their theoretical analysis in the Journal, Hutcheon et al. (Am J Epidemiol 2016;184(3):227-232) critiqued the existing evidence of the fetal benefits of maternal influenza immunization by calculating the sample sizes needed to demonstrate hypothetical reductions in risk and concluded that the benefits observed in empirical studies are likely implausible...
December 1, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27765646/relationship-of-childhood-adversity-and-neighborhood-violence-to-a-proinflammatory-phenotype-in-emerging-adult-african-american-men-an-epigenetic-link
#15
Linda Witek Janusek, Dina Tell, Noni Gaylord-Harden, Herbert L Mathews
African American men (AAM) who are exposed to trauma and adversity during their early life are at greater risk for poor health over their lifespan. Exposure to adversity during critical developmental windows may embed an epigenetic signature that alters expression of genes that regulate stress response systems, including those genes that regulate the inflammatory response to stress. Such an epigenetic signature may increase risk for diseases exacerbated by inflammation, and may contribute to health disparity...
February 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27760029/antioxidant-and-anti-inflammatory-activities-of-a-commercial-noni-juice-revealed-by-carrageenan-induced-paw-edema
#16
N Yilmazer, C Coskun, E Gurel-Gurevin, I Yaylim, E H Eraltan, E I Ikitimur-Armutak
This study aimed to investigate antioxidant and anti-inflammatory activities of a commercial product of noni (Morinda citrifolia) juice. Carrageenan-induced rat paw edema was employed as inflammatory model. One control and three experimental groups were formed. Experimental groups were administered noni juice alone, noni juice+carrageenan, and carrageenan alone. Oxidant and antioxidant capacity were determined by d-ROMs test and BAP test, respectively. Plasma concentrations of endothelin-1 and leptin were measured by ELISA...
September 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/27745953/commentary-to-how-to-respond-to-vocal-vaccine-deniers-in-public
#17
Philipp Schmid, Noni E MacDonald, Katrine Habersaat, Robb Butler
No abstract text is available yet for this article.
October 13, 2016: Vaccine
https://www.readbyqxmd.com/read/27729866/methanolic-extract-of-morinda-citrifolia-l-noni-unripe-fruit-attenuates-ethanol-induced-conditioned-place-preferences-in-mice
#18
Yasmin Khan, Vijayapandi Pandy
Phytotherapy is an emerging field successfully utilized to treat various chronic diseases including alcohol dependence. In the present study, we examined the effect of the standardized methanolic extract of Morinda citrifolia Linn. unripe fruit (MMC), on compulsive ethanol-seeking behavior using the mouse conditioned place preference (CPP) test. CPP was established by injections of ethanol (2 g/kg, i.p.) in a 12-day conditioning schedule in mice. The effect of MMC and the reference drug, acamprosate (ACAM), on the reinforcing properties of ethanol in mice was studied by the oral administration of MMC (1, 3, and 5 g/kg) and ACAM (300 mg/kg) 60 min prior to the final CPP test postconditioning...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27664661/protein-breakdown-and-release-of-%C3%AE-casomorphins-during-in-vitro-gastro-intestinal-digestion-of-sterilised-model-systems-of-liquid-infant-formula
#19
Stefano Cattaneo, Milda Stuknytė, Fabio Masotti, Ivano De Noni
Protein modifications occurring during sterilisation of infant formulas can affect protein digestibility and release of bioactive peptides. The effect of glycation and cross-linking on protein breakdown and release of β-casomorphins was evaluated during in vitro gastro-intestinal digestion (GID) of six sterilised model systems of infant formula. Protein degradation during in vitro GID was evaluated by SDS-PAGE and by measuring the nitrogen content of ultrafiltration (3kDa) permeates before and after in vitro GID of model IFs...
February 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27601432/increasing-airway-obstruction-from-8-to-18%C3%A2-years-in-extremely-preterm-low-birthweight-survivors-born-in-the-surfactant-era
#20
Lex W Doyle, Anne-Marie Adams, Colin Robertson, Sarath Ranganathan, Noni M Davis, Katherine J Lee, Jeanie L Cheong
BACKGROUND: The evolution of airway obstruction into late adolescence of extremely preterm (gestational age <28 weeks) or extremely low-birthweight (birth weight <1000 g) survivors in the era after surfactant was introduced is unclear. OBJECTIVE: To compare changes in spirometry from 8 to 18 years of age of a geographical cohort of preterm survivors with normal birth weight controls, and to determine higher risk groups within the preterm cohort. METHODS: Of 297 extremely preterm/low-birthweight survivors born in 1991-1992 in the state of Victoria, Australia, 81% and 70% had spirometry at 8 and 18 years of age, respectively...
September 6, 2016: Thorax
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