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https://www.readbyqxmd.com/read/28724122/association-between-patient-age-and-lymph-node-positivity-in-thin-melanoma
#1
Andrew J Sinnamon, Madalyn G Neuwirth, Pratyusha Yalamanchi, Phyllis Gimotty, David E Elder, Xiaowei Xu, Rachel R Kelz, Robert E Roses, Emily Y Chu, Michael E Ming, Douglas L Fraker, Giorgos C Karakousis
Importance: More than half of all new melanoma diagnoses present as clinically localized T1 melanoma, yet sentinel lymph node biopsy (SLNB) is controversial in this population given the overall low yield. Guidelines for SLNB have focused on pathologic factors, but patient factors, such as age, are not routinely considered. Objectives: To identify indicators of lymph node (LN) metastasis in thin melanoma in a large, generalizable data set and to evaluate the association between patient age and LN positivity...
July 19, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28717562/development-of-thin-skin-mimicking-bilayer-solid-tissue-phantoms-for-optical-spectroscopic-studies
#2
K Bala Nivetha, N Sujatha
In vivo spectroscopic measurements have the proven potential to provide important insight about the changes in tissue during the development of malignancies and thus help to diagnose tissue pathologies. Extraction of intrinsic data in the presence of varying amounts of scatterers and absorbers offers great challenges in the development of such techniques to the clinical level. Fabrication of optical phantoms, tailored to the biochemical as well as morphological features of the target tissue, can help to generate a spectral database for a given optical spectral measurement system...
July 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28691840/eating-disorder-specific-risk-factors-moderate-the-relationship-between-negative-urgency-and-binge-eating-a-behavioral-genetic-investigation
#3
Sarah E Racine, Jessica L VanHuysse, Pamela K Keel, S Alexandra Burt, Michael C Neale, Steven Boker, Kelly L Klump
Theoretical models of binge eating and eating disorders include both transdiagnostic and eating disorder-specific risk factors. Negative urgency (i.e., the tendency to act impulsively when distressed) is a critical transdiagnostic risk factor for binge eating, but limited research has examined interactions between negative urgency and disorder-specific variables. Investigating these interactions can help identify the circumstances under which negative urgency is most strongly associated with binge eating. We examined whether prominent risk factors (i...
July 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28654548/histopathologic-review-of-negative-sentinel-lymph-node-biopsies-in-thin-melanomas-an-argument-for-the-routine-use-of-immunohistochemistry
#4
Anne M Stowman, Alexandra W Hickman, Alejandro A Gru, Craig L Slingluff
Sentinel lymph node biopsy (SLNB) is performed for some thin melanomas in the presence of concerning histopathological features. There are no defined standards for how sentinel nodes should be processed to detect microscopic metastases. We compared our method of serially sectioning nodes at 2-3 mm intervals and performing one hematoxylin and eosin (H&E) slide versus multiple H&E levels and utilizing immunohistochemistry (IHC). This was a retrospective review of a prospectively collected database identified patients with thin melanomas treated with wide local excision and SLNB between 1995 and 2010...
August 2017: Melanoma Research
https://www.readbyqxmd.com/read/28651424/estimated-glomerular-filtration-rate-renal-scan-and-volumetric-assessment-of-the-kidney-before-and-after-partial-nephrectomy-a-review-of-the-current-literature
#5
Riccardo G Bertolo, Homayoun Zargar, Riccardo Autorino, Cristian Fiori, Jihad H Kaouk, Paul Russo, Robert H Thompson, Francesco Porpiglia
INTRODUCTION: The best method for assessing renal function after partial nephrectomy (PN) continues to be a matter of debate. Early studies evaluated kidney function by measuring serum creatinine (sCr) and/or the estimated glomerular filtration rate (eGFR), potentially underestimating the contribution of the contralateral kidney in masking alterations in renal function. Since then, researchers have studied the operated renal unit with the aid of nuclear renal scans (RS). However, taking into consideration the importance of the amount of renal parenchyma spared or sacrificed during PN, many novel methods have been proposed for determining kidney volume before and after PN...
June 23, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28640657/retinal-findings-on-oct-in-systemic-conditions
#6
Preeti Patil Chhablani, Vikas Ambiya, Akshay G Nair, Sailaja Bondalapati, Jay Chhablani
PURPOSE: Imaging technology has advanced by leaps and bounds in the recent past and has resulted in a much greater understanding of ocular diseases. The aim of this review article is to summarize optical coherence tomography (OCT) findings of various systemic conditions. METHOD: A systematic literature search of the Medline/PubMed database was performed. English articles up to April 2015 were included. Terms used for search included: Alzheimer's Disease; Multiple Sclerosis; Parkinson's Disease; Behçet's Disease; Schizophrenia; Migraine; Obstructive Sleep Apnea Syndrome; Neurofibromatosis; Sickle Cell Disease; Renal diseases; Lupus Retinopathy; Valsalva Retinopathy; Whiplash Retinopathy; Shaken-Baby Syndrome; Choroidal metastases; Intracranial Hypertension; Drug toxicity; Deferoxamine; Sildenafil; Tamoxifen; Hydroxychloroquine; Chloroquine; Ethambutol; Lead; Sickle Cell Disease; and Thalassemia along with OCT...
June 22, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28632452/the-effect-of-g-csf-on-infertile-women-undergoing-ivf-treatment-a-meta-analysis
#7
Jie Li, Sien Mo, Yang Chen
Evidence for the effect of granulocyte colony stimulating factor (G-CSF) on infertile women undergoing in vitro fertilization (IVF) remains inconsistent. This study aimed to evaluate the effectiveness of G-CSF on infertile women undergoing IVF. PubMed and EMBASE databases were searched before August 2016. Comparing the transvaginal perfusion of G-CSF and placebo or no treatment, the available studies were considered. The pooled risk ratio (RR) with 95% confidence intervals (CIs) was used in the analysis and six studies were included...
August 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28632041/automated-volumetry-of-hippocampus-is-useful-to-confirm-unilateral-mesial-temporal-sclerosis-in-patients-with-radiologically-positive-findings
#8
Guilherme Silva, Cristina Martins, Nádia Moreira da Silva, Duarte Vieira, Dias Costa, Ricardo Rego, José Fonseca, João Paulo Silva Cunha
Background and purpose We evaluated two methods to identify mesial temporal sclerosis (MTS): visual inspection by experienced epilepsy neuroradiologists based on structural magnetic resonance imaging sequences and automated hippocampal volumetry provided by a processing pipeline based on the FMRIB Software Library. Methods This retrospective study included patients from the epilepsy monitoring unit database of our institution. All patients underwent brain magnetic resonance imaging in 1.5T and 3T scanners with protocols that included thin coronal T2, T1 and fluid-attenuated inversion recovery and isometric T1 acquisitions...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28622550/effect-of-gels-containing-chlorhexidine-or-epigallocatechin-3-gallate-on-the-protein-composition-of-the-acquired-enamel-pellicle
#9
Cíntia Maria de Souza-E-Silva, Talita Mendes da Silva Ventura, Luiza de Pau, la Silva Cassiano, Aline de Lima Leite, Marília Afonso Rabelo Buzalaf
OBJECTIVE: This study evaluated changes in protein profile of the acquired enamel pellicle (AEP) formed in vivo, after application of gels containing chlorhexidine or EGCG and further challenge with citric acid. DESIGN: AEP was formed in 9 volunteers for 2h and then treated with one of the following gels: placebo, 400μM EGCG or 0.012% chlorhexidine. A thin layer of gel was applied and after 1min the excess was removed. One hour after gel application, the AEP was collected from the buccal surface (upper and lower jaw) of one of the sides with filter paper dipped in 3% citric acid...
June 3, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28612381/body-mass-index-as-a-predictor-of-outcomes-among-pediatric-kidney-transplant-recipient
#10
André A S Dick, Ryan N Hansen, Martin I Montenovo, Patrick J Healey, Jodi M Smith
Controversies exist regarding the impact of obesity on patients undergoing kidney transplantation. We sought to estimate the association between BMI and patient outcomes (survival and graft function) among pediatric kidney transplant patients in the USA. We conducted a retrospective analysis of the United Network for Organ Sharing database (1987-2013), which revealed 13 014 pediatric patients (<18 years old) who underwent primary kidney transplantation. Patients were stratified into five BMI categories established by the World Health Organizations according to their Z score, which is based on age, gender and BMI...
June 13, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28605551/abc-2-method-does-not-accurately-predict-cerebral-arteriovenous-malformation-volume
#11
Christopher Roark, Venu Vadlamudi, Neeraj Chaudhary, Joseph J Gemmete, Joshua Seinfeld, B Gregory Thompson, Aditya S Pandey
BACKGROUND: Stereotactic radiosurgery (SRS) is a treatment option for cerebral arteriovenous malformations (AVMs) to prevent intracranial hemorrhage. The decision to proceed with SRS is usually based on calculated nidal volume. Physicians commonly use the ABC/2 formula, based on digital subtraction angiography (DSA), when counseling patients for SRS. OBJECTIVE: To determine whether AVM volume calculated using the ABC/2 method on DSA is accurate when compared to the exact volume calculated from thin-cut axial sections used for SRS planning...
June 10, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28598761/the-health-economic-burden-that-acute-and-chronic-wounds-impose-on-an-average-clinical-commissioning-group-health-board-in-the-uk
#12
J F Guest, K Vowden, P Vowden
OBJECTIVE: To estimate the patterns of care and related resource use attributable to managing acute and chronic wounds among a catchment population of a typical clinical commissioning group (CCG)/health board and corresponding National Health Service (NHS) costs in the UK. METHOD: This was a sub-analysis of a retrospective cohort analysis of the records of 2000 patients in The Health Improvement Network (THIN) database. Patients' characteristics, wound-related health outcomes and health-care resource use were quantified for an average CCG/health board with a catchment population of 250,000 adults ≥18 years of age, and the corresponding NHS cost of patient management was estimated at 2013/2014 prices...
June 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28597282/the-general-surgeon-s-perspective-of-rectus-diastasis-a-systematic-review-of-treatment-options
#13
Elwin H H Mommers, Jeroen E H Ponten, Aminah K Al Omar, Tammo S de Vries Reilingh, Nicole D Bouvy, Simon W Nienhuijs
BACKGROUND: Diastasis of the rectus abdominis muscles (DRAM) is characterised by thinning and widening of the linea alba, combined with laxity of the ventral abdominal musculature. This causes the midline to "bulge" when intra-abdominal pressure is increased. Plastic surgery treatment for DRAM has been thoroughly evaluated, though general surgical treatments and the efficacy of physiotherapy remain elusive. The aim of this systematic literature review is to evaluate both general surgical and physiotherapeutic treatment options for restoring DRAM in terms of postoperative complications, patient satisfaction, and recurrence rates...
June 8, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28596752/the-retina-in-multiple-system-atrophy-systematic-review-and-meta-analysis
#14
REVIEW
Carlos E Mendoza-Santiesteban, Iñigo Gabilondo, Jose Alberto Palma, Lucy Norcliffe-Kaufmann, Horacio Kaufmann
BACKGROUND: Multiple system atrophy (MSA) is a rare, adult-onset, rapidly progressive fatal synucleinopathy that primarily affects oligodendroglial cells in the brain. Patients with MSA only rarely have visual complaints, but recent studies of the retina using optical coherence tomography (OCT) showed atrophy of the peripapillary retinal nerve fiber layer (RNFL) and to a lesser extent the macular ganglion cell layer (GCL) complex. METHODS: We performed a literature review and meta-analysis according to the preferred reporting items for systematic reviews and meta-analyses guidelines for studies published before January 2017, identified through PubMed and Google Scholar databases, which reported OCT-related outcomes in patients with MSA and controls...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28562108/characteristics-of-children-and-adolescents-first-prescribed-proton-pump-inhibitors-or-histamine-2-receptor-antagonists-an-observational-cohort-study
#15
Ana Ruigómez, Leanne M A Kool-Houweling, Luis A García Rodríguez, Fernie J A Penning-van Beest, Ron M C Herings
OBJECTIVE: To describe the characteristics of pediatric patients prescribed proton pump inhibitors (PPIs) vs those of pediatric patients prescribed histamine-2-receptor antagonists (H2RAs). METHODS: Observational studies were conducted using The Health Improvement Network (THIN) and the PHARMO Database Network. Patients aged 0-18 years who were first prescribed a PPI or H2RA between October 1, 2009 and September 30, 2012 (THIN) or between September 1, 2008 and August 31, 2011 (PHARMO) were included...
June 9, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28541069/reading-between-the-menu-lines-are-restaurants-descriptions-of-healthy-foods-unappealing
#16
Bradley P Turnwald, Dan Jurafsky, Alana Conner, Alia J Crum
OBJECTIVE: As obesity rates continue to climb in America, much of the blame has fallen on the high-calorie meals at popular chain restaurants. Many restaurants have responded by offering "healthy" menu options. Yet menus' descriptions of healthy options may be less attractive than their descriptions of less healthy, standard options. This study examined the hypothesis that the words describing items in healthy menu sections are less appealing than the words describing items in standard menu sections...
May 25, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28540544/five-year-volume-growth-of-european-beech-does-not-respond-to-ozone-pollution-in-italy
#17
Elena Paoletti, Alessandra De Marco, Alessandro Anav, Patrizia Gasparini, Enrico Pompei
A unique database of stand volume growth, estimated as periodic annual volume increment (in m(3) ha(-1) per year over the period 2001-2005) from 728 European beech (Fagus sylvatica L.) sites distributed across Italy, was used to assess the effects of ambient ozone (O3), expressed as annual average (M24), accumulated exposure above a 40 ppb hourly threshold (AOT40), and total stomatal ozone flux (POD0). Growth data were from the National forest inventory of Italy, while climate data and ozone concentrations were computed by the WRF and CHIMERE models, respectively...
May 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28517971/soft-tissue-changes-around-immediately-placed-implants-a-systematic-review-and-meta-analyses-with-at-least-12-months-follow-up-after-functional-loading
#18
Bassam M Kinaia, Filip Ambrosio, Periodontal Resident, Monica Lamble, Periodontal Resident, Kristyn Hope, Periodontal Resident, Maanas Shah, Anthony L Neely
BACKGROUND: Immediate implant placement (IIP) is predictable but can lead to esthetic challenges including mid-facial recession (MFR) and papillary height (PH) loss. The focused question of this systematic review was: What is the effect of IIP on MFR and PH after at least 12-months of functional loading? METHODS: Literature review of the COCHRANE and MEDLINE electronic databases and hand search up to January 2016 identified eligible studies. Four reviewers independently assessed data quality and methodology...
May 18, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28497881/efficacy-of-intrauterine-perfusion-of-granulocyte-colony-stimulating-factor-g-csf-for-infertile-women-with-thin-endometrium-a-systematic-review-and-meta-analysis
#19
Yiran Xie, Tao Zhang, Zhengping Tian, Jiamiao Zhang, Wanxue Wang, Hong Zhang, Yong Zeng, Jianping Ou, Yihua Yang
This meta-analysis aimed to explore the efficiency of intrauterine perfusion of granulocyte colony-stimulating factor (G-CSF) on infertile women with thin endometrium. Following PRISMA protocol, we conducted a comprehensive search of academic literatures on various databases including PubMed, EMbase, and Cochrane Library. Studies published in English before July 1, 2016 were included for primary screening. Data on the thickness of endometrium, cycle cancelation rate,clinical pregnancy rate, and embryo implantation rate were extracted and analyzed, respectively...
May 12, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28495341/estimation-of-the-prevalence-of-adverse-drug-reactions-from-social-media
#20
Thin Nguyen, Mark E Larsen, Bridianne O'Dea, Dinh Phung, Svetha Venkatesh, Helen Christensen
This work aims to estimate the degree of adverse drug reactions (ADR) for psychiatric medications from social media, including Twitter, Reddit, and LiveJournal. Advances in lightning-fast cluster computing was employed to process large scale data, consisting of 6.4 terabytes of data containing 3.8 billion records from all the media. Rates of ADR were quantified using the SIDER database of drugs and side-effects, and an estimated ADR rate was based on the prevalence of discussion in the social media corpora...
June 2017: International Journal of Medical Informatics
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