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https://www.readbyqxmd.com/read/28333492/perceptual-and-memory-inhibition-deficits-in-clinically-healthy-older-adults-are-associated-with-region-specific-doubly-dissociable-patterns-of-cortical-thinning
#1
Teal S Eich, Qolamreza R Razlighi, Yaakov Stern
Converging evidence suggests that the cognitive control processes that enable the inhibition of irrelevant information on a perceptual versus a memorial basis are qualitatively different and are underlain by unique neural systems that may be affected differentially in aging. In the current study, we investigated whether individual differences in performance on these 2 types of inhibitory processes were attributable to region-specific patterns of cortical thinning. Clinically healthy older adults completed a pair of behavioral memory and perceptual inhibition tasks and then underwent structural brain imaging...
March 23, 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28323967/all-cause-mortality-in-patients-with-diabetes-under-treatment-with-dapagliflozin-a-population-based-open-cohort-study-in-thin-database
#2
Konstantinos A Toulis, Brian H Willis, Tom Marshall, Balachadran Kumarendran, Krishna Gokhale, Sandip Ghosh, G Neil Thomas, Kar Keung Cheng, Parth Narendran, Wasim Hanif, Krishnarajah Nirantharakumar
Context: Empagliflozin was found to decrease mortality in patients with type 2 diabetes (T2DM) and a prior cardiovascular (CVD) event. Objectives: To establish whether these benefits can be replicated in a real-world setting, should be expected with the use of dapagliflozin, and apply to T2DM patients at low risk of CVD. Design: General Practice, population-based, retrospective cohort study (January 2013-September 2015). Setting: The Health Improvement Network Database (THIN)...
February 20, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28296949/death-following-partner-bereavement-a-self-controlled-case-series-analysis
#3
Michael King, Rebecca Lodwick, Rebecca Jones, Heather Whitaker, Irene Petersen
BACKGROUND: There is mixed evidence that older people bereaved of a spouse or partner are at risk of adverse outcomes. The main difficulty is to take account of other explanatory factors. We tested for an association between a patient's death and the timing of any bereavement of a cohabitee. METHOD: Self-controlled case series study in which each case serves as his or her own control and which thereby accounts for all fixed measurable and unmeasurable confounders...
2017: PloS One
https://www.readbyqxmd.com/read/28289013/prescription-rates-of-adrenaline-auto-injectors-for-children-in-uk-general-practice-a-retrospective-cohort-study
#4
Lavanya Diwakar, Carole Cummins, Ronan Ryan, Tom Marshall, Tracy Roberts
BACKGROUND: Adrenaline auto-injectors (AAI) should be provided to individuals considered to be at high risk of anaphylaxis. There is some evidence that the rate of AAI prescription is increasing, but the true extent has not been previously quantified. AIM: To estimate the trends in annual GP-issued prescriptions for AAI among UK children between 2000 and 2012. DESIGN AND SETTING: Retrospective cohort study using data from primary care practices that contributed to The Health Improvement Network (THIN) database...
March 13, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28281244/effectiveness-of-liraglutide-and-lixisenatide-in-the-treatment-of-type-2-diabetes-real-world-evidence-from-the-health-improvement-network-thin-database-in-the-united-kingdom
#5
Michael Feher, Gabriela Vega-Hernandez, Emina Mocevic, Brian Buysse, Melissa Myland, Geraldine S Power, Lise L Nystrup Husemoen, Joseph Kim, Daniel R Witte
INTRODUCTION: The glucagon-like peptide-1 receptor agonists liraglutide and lixisenatide are effective at reducing glycated hemoglobin (HbA1c) levels in patients with type 2 diabetes mellitus (T2DM). Although liraglutide has demonstrated superior efficacy in head-to-head clinical trials, real-world evidence of comparative effectiveness is lacking. This observational study aimed to assess the effectiveness of liraglutide versus lixisenatide in UK clinical practice. METHODS: Electronic medical records from The Health Improvement Network (THIN) UK primary care database were analyzed...
March 9, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28279314/meta-analysis-of-randomized-clinical-trials-comparing-biodegradable-polymer-drug-eluting-stent-to-second-generation-durable-polymer-drug-eluting-stents
#6
Georges El-Hayek, Sripal Bangalore, Abel Casso Dominguez, Chandan Devireddy, Wissam Jaber, Gautam Kumar, Kreton Mavromatis, Jacqueline Tamis-Holland, Habib Samady
OBJECTIVES: The authors sought to perform a meta-analysis of randomized clinical trials (RCTs) comparing the safety and efficacy of biodegradable polymer drug-eluting stents (BP-DES) to second-generation durable polymer drug-eluting stents (DP-DES). BACKGROUND: Prior meta-analyses have established the superiority of BP-DES over bare-metal stents and first-generation DP-DES; however, their advantage compared with second-generation DP-DES remains controversial. METHODS: The authors searched PubMed and Scopus databases for RCTs comparing BP-DES to the second-generation DP-DES...
March 13, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28277713/relational-antecedents-and-social-implications-of-the-emotion-of-empathy-evidence-from-three-studies
#7
Sanghag Kim, Grazyna Kochanska
Despite emotion researchers' strong interest in empathy and its implications for prosocial functioning, surprisingly few studies have examined parent-child attachment as a context for early origins of empathy in young children. Consequently, empirical evidence on links among children's attachment, empathy, and prosociality is thin and inconsistent. We examined such links in 2 longitudinal studies of community families (Family Study, N = 101 mothers, fathers, and children, 14 to 80 months; Parent-Child Study, mothers and children, N = 108, 15 to 45 months) and a study of low-income, diverse mothers and toddlers (Play Study, N = 186, 30 months)...
March 9, 2017: Emotion
https://www.readbyqxmd.com/read/28243630/redefining-the-phenotype-of-alsp-and-aars2-mutation-related-leukodystrophy
#8
REVIEW
Rahul Lakshmanan, Matthew E Adams, David S Lynch, Justin A Kinsella, Rahul Phadke, Jonathan M Schott, Elaine Murphy, Jonathan D Rohrer, Jeremy Chataway, Henry Houlden, Nick C Fox, Indran Davagnanam
OBJECTIVE: To provide an overview of the phenotype of 2 clinically, radiologically, and pathologically similar leukodystrophies, adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and alanyl-transfer RNA synthetase 2 mutation-related leukodystrophy (AARS2-L), and highlight key differentiating features. METHODS: ALSP and AARS2-L cases were identified from the adult-onset leukodystrophy database at our institution. In addition, cases with imaging findings were identified from a literature review...
April 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28241970/automated-segmental-imt-measurement-in-thin-thick-plaque-with-bulb-presence-in-carotid-ultrasound-from-multiple-scanners-stroke-risk-assessment
#9
Nobutaka Ikeda, Nilanjan Dey, Aditya Sharma, Ajay Gupta, Soumyo Bose, Suvojit Acharjee, Shoaib Shafique, Elisa Cuadrado-Godia, Tadashi Araki, Luca Saba, John R Laird, Andrew Nicolaides, Jasjit S Suri
BACKGROUND AND OBJECTIVES: Standardization of the carotid IMT requires a reference marker in ultrasound scans. It has been shown previously that manual reference marker and manually created carotid segments are used for measuring IMT in these segments. Manual methods are tedious, time consuming, subjective, and prone to errors. Bulb edge can be considered as a reference marker for measurements of the cIMT. However, bulb edge can be difficult to locate in ultrasound scans due to: (a) low signal to noise ratio in the bulb region as compared to common carotid artery region; (b) uncertainty of bulb location in craniocaudal direction; and (c) variability in carotid bulb shape and size...
April 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28211977/1q21-3-deletion-involving-gatad2b-an-emerging-recurrent-microdeletion-syndrome
#10
Thipwimol Tim-Aroon, Natini Jinawath, Weerin Thammachote, Praweena Sinpitak, Anchalee Limrungsikul, Chaiyos Khongkhatithum, Duangrurdee Wattanasirichaigoon
GATAD2B gene is involved in chromatin modification and transcription activity. Loss-of-function mutations of GATAD2B have recently been defined to cause a recognizable syndrome with intellectual disability (ID). Human TPM3 gene encoding thin filament protein is associated with myopathies. Both genes are located on chromosome 1q21.3. We herein report an infant with feeding difficulty, developmental delay, hypotonia, and dysmorphic features including small palpebral fissures, telecanthus, sparse hair and eyebrow, cup-shaped ears, and clinodactyly...
March 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28170450/zirconia-implants-as-an-alternative-to-titanium-a-systematic-review-and-meta-analysis
#11
Basel Elnayef, Aida Lázaro, Fernando Suárez-López Del Amo, Pablo Galindo-Moreno, Hom-Lay Wang, Jordi Gargallo-Albiol, Federico Hernández-Alfaro
PURPOSE: The aim of the present study was to systematically evaluate the marginal bone loss (MBL), success, and survival of zirconia (Zi) implants and compare them with the widely studied titanium (Ti) implants. MATERIALS AND METHODS: An electronic and manual literature search of several databases was performed by two independent reviewers for articles up to July 2015 that reported the use of Zi implants and survival, success, and MBL with at least 12 months' follow-up...
February 7, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28160348/phoma-crystallifera-with-phytotoxic-effects-and-pathogenic-potential-against-field-bindweed-convolvulus-arvensis-l-in-iran
#12
Parisa Razaghi, Doustmorad Zafari
AIMS: To identify a potential pathogenic isolate of fungus on Convolvulus arvensis and to determine its phytotoxic activity, which revealed the presence of toxic metabolites responsible for the toxicity against the target weed. METHODS AND RESULTS: A high virulent isolate of the fungus, Phoma crystallifera was isolated from symptomatic field bindweed in the west of Iran and was screened for the production of phytotoxins, which promoted necrosis on the detached leaves and seedlings of field bindweed in the bioassays...
February 4, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28133890/characterization-of-new-users-of-cilostazol-in-the-uk-spain-sweden-and-germany
#13
Jordi Castellsague, Susana Perez-Gutthann, Brian Calingaert, Christine Bui, Cristina Varas-Lorenzo, Alejandro Arana, Alexandra Prados-Torres, Beatriz Poblador-Plou, Francisca Gonzalez-Rubio, Maria Giner-Soriano, Albert Roso-Llorach, Marie Linder, Anna Citarella, Oliver Scholle, Tilo Blenk, Edeltraut Garbe
PURPOSE: To describe the characteristics of new users of cilostazol in Europe with the aim to support the evaluation of its benefit/risk as used in regular clinical practice before the implementation of labeling changes recommended by the European Medicines Agency. METHODS: New users of cilostazol were identified in populations enrolled in five European health automated databases in the UK (The Health Improvement Network [THIN]), Spain (EpiChron cohort and Information System for the Improvement of Research in Primary Care [SIDIAP]), Sweden (National Registers), and Germany (German Pharmacoepidemiological Research Database [GePaRD]) between 2002 and 2012...
January 30, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28132159/analysis-of-sentinel-node-positivity-in-primary-cutaneous-melanoma-an-8-year-single-institution-experience
#14
K M Joyce, N M McInerney, R P Piggott, F Martin, D M Jones, A J Hussey, M J Kerin, J L Kelly, P J Regan
BACKGROUND: Sentinel lymph node biopsy (SLNB) is a standard method for determining the pathologic status of the regional lymph nodes. AIMS: The aim of our study was to determine the incidence and clinicopathologic factors predictive of SLN positivity, and to evaluate the prognostic importance of SLNB in patients with cutaneous melanoma. METHODS: We performed a retrospective analysis of a prospectively maintained database of all patients who underwent SLNB for primary melanoma at our institution from 2005 to 2012...
January 28, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28121641/suboptimal-compliance-with-national-comprehensive-cancer-network-melanoma-guidelines-who-is-at-risk
#15
Andrew M Blakely, Danielle S Comissiong, Michael P Vezeridis, Thomas J Miner
BACKGROUND: National Comprehensive Cancer Network (NCCN) melanoma treatment guidelines are based on best available literature. We evaluated NCCN excision margin and sentinel lymph node biopsy (SLNB) guideline adherence to identify patient populations at risk for suboptimal care. METHODS: Retrospective review of prospectively maintained database of all patients who underwent operation for invasive melanoma from January 2005 to 2015. RESULTS: In total, 865 patients underwent operation for 522 thin (60...
January 24, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28119386/survival-prospects-after-acute-myocardial-infarction-in-the-uk-a-matched-cohort-study-1987-2011
#16
Lisanne A Gitsels, Elena Kulinskaya, Nicholas Steel
OBJECTIVES: Estimate survival after acute myocardial infarction (AMI) in the general population aged 60 and over and the effect of recommended treatments. DESIGN: Cohort study in the UK with routinely collected data between January 1987 and March 2011. SETTING: 310 general practices that contributed to The Health Improvement Network (THIN) database. PARTICIPANTS: 4 cohorts who reached the age of 60, 65, 70, or 75 years between 1987 and 2011 included 16 744, 43 528, 73 728, and 76 392 participants, respectively...
January 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28108171/patellar-cut-and-composite-thickness-the-influence-on-postoperative-motion-and-complications-in-total-knee-arthroplasty
#17
William G Hamilton, Deborah J Ammeen, Nancy L Parks, Nitin Goyal, Gerard A Engh, C Anderson Engh
BACKGROUND: Little data exist on the influence of patellar thickness on postoperative motion or complications after total knee arthroplasty (TKA). This study addresses the following questions: Is postoperative motion influenced by change in composite patellar thickness? Is change in patellar thickness associated with more complications? And do more complications occur in the knees with a patellar bone remnant (<12 mm) and a native patellar thickness <18 mm? METHODS: In total, 3655 TKAs were performed by 3 surgeons over a 28-year interval...
December 27, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28077570/ktcnlncdb-a-first-platform-to-investigate-lncrnas-expressed-in-human-keratoconus-and-non-keratoconus-corneas
#18
Michał W Szcześniak, Michal Kabza, Justyna A Karolak, Malgorzata Rydzanicz, Dorota M Nowak, Barbara Ginter-Matuszewska, Piotr Polakowski, Rafal Ploski, Jacek P Szaflik, Marzena Gajecka
Keratoconus (KTCN, OMIM 148300) is a degenerative eye disorder characterized by progressive stromal thinning that leads to a conical shape of the cornea, resulting in optical aberrations and even loss of visual function. The biochemical background of the disease is poorly understood, which motivated us to perform RNA-Seq experiment, aimed at better characterizing the KTCN transcriptome and identification of long non-coding RNAs (lncRNAs) that might be involved in KTCN etiology. The in silico functional studies based on predicted lncRNA:RNA base-pairings led us to recognition of a number of lncRNAs possibly regulating genes with known or plausible links to KTCN...
2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/28056391/proton-pump-inhibitors-on-pancreatic-cancer-risk-and-survival
#19
Malcolm D Kearns, Ben Boursi, Yu-Xiao Yang
BACKGROUND: Hypergastrinemia may promote the development and progression of pancreatic cancer. Proton pump inhibitor (PPI) therapy is known to cause hypergastrinemia. We sought to determine the association between PPI therapy and the risk of developing pancreatic cancer as well as survival following pancreatic cancer diagnosis. METHODS: We conducted a nested case-control study and a retrospective cohort study in The Health Improvement Network (THIN), a medical records database representative of the UK population...
February 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28050865/creation-and-characterization-of-normal-myocardial-perfusion-imaging-databases-using-the-iq%C3%A2-spect-system
#20
Koichi Okuda, Kenichi Nakajima, Shinro Matsuo, Chisato Kondo, Masayoshi Sarai, Yoriko Horiguchi, Takahiro Konishi, Masahisa Onoguchi, Takeshi Shimizu, Seigo Kinuya
BACKGROUND: Image acquisition by short-time single-photon emission-computed tomography (SPECT) has been made feasible by IQ·SPECT. The aim of this study was to generate normal databases (NDBs) of thallium-201 ((201)Tl) myocardial perfusion imaging for IQ·SPECT, and characterize myocardial perfusion distribution. METHODS AND RESULTS: We retrospectively enrolled 159 patients with a low likelihood of cardiac diseases from four hospitals in Japan. All patients underwent short-time (201)Tl myocardial perfusion IQ·SPECT with or without attenuation and scatter correction (ACSC) in either supine or prone position...
January 3, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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