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https://www.readbyqxmd.com/read/29134723/the-ct-defined-hyperdense-arterial-sign-as-a-marker-for-acute-intracerebral-large-vessel-occlusion
#1
Jaims Lim, Jordan A Magarik, Michael T Froehler
BACKGROUND AND PURPOSE: To determine the sensitivity and specificity of the hyperdense artery sign (HAS) on thin-slice non-contrast computed tomography (NCCT), combined with brief clinical history, as an indicator for large vessel occlusion (LVO) in the setting of acute ischemic stroke. METHODS: Ninety-nine LVO and 102 non-LVO acute ischemic stroke patients were retrospectively identified from a prospective database at a single institution. After reviewing each patient's neurologic presentation based on his or her initial National Institute of Health Stroke Scale (NIHSS) and neurologic evaluation, all thin (1 mm) and thick (5 mm) NCCT scans were reviewed for the HAS...
November 14, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29121851/outputs-and-growth-of-primary-care-databases-in-the-united-kingdom-bibliometric-analysis
#2
Zain Chaudhry, Fahmida Mannan, Angela Gibson-White, Usama Syed, Shirin Ahmed, Antonis Kousoulis, Azeem Majeed
BACKGROUND: Electronic health database (EHD) data is increasingly used by researchers. The major United Kingdom EHDs are the 'Clinical Practice Research Datalink' (CPRD), 'The Health Improvement Network' (THIN) and 'QResearch'. Over time, outputs from these databases have increased, but have not been evaluated. OBJECTIVE: This study compares research outputs from CPRD, THIN and QResearch assessing growth and publication outputs over a 10-year period (2004-2013)...
October 17, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/29112483/clinicopathologic-factors-predictive-of-occult-lymph-node-involvement-in-cutaneous-head-and-neck-melanoma
#3
Pratyusha Yalamanchi, Jason A Brant, Jinbo Chen, Jason G Newman
Objectives Evaluate clinicopathologic factors contributing to regional lymph node (LN) metastases in cutaneous head and neck melanoma (HNM). Study Design Retrospective review of a national cancer database. Setting National Cancer Database (2004-2012). Methods National Cancer Database (NCDB) cases diagnosed between 2004 and 2012 were reviewed. Inclusion criteria were head and neck cutaneous site codes, melanoma histology codes, and clinically node-negative status. Independent, clinicopathologic factors associated with pathologic positive LN status were identified by multivariable logistic regression...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29082560/e12-sheet-plastination-techniques-and-applications
#4
REVIEW
Nicolas Ernesto Ottone, Carlos Baptista, Rafael Latorre, Homero Felipe Bianchi, Mariano Del Sol, Ramon Fuentes
INTRODUCTION: Plastination is an anatomical technique that consists of replacing the liquids and fat of specimens by reactive polymers through forced impregnation in a vacuum. These are then polymerized to achieve the final result. E12 sheet plastination involves epoxy resin impregnation of thin (2-4 mm) and ultra-thin (less than 2 mm) tissue sheets, producing dry, transparent, odorless, non-toxic and long-lasting sheets. MATERIALS AND METHODS: E12 sheet plastination techniques were reviewed using MEDLINE, EMBASE and SciELO databases, and manual searches...
October 30, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/29061715/statin-initiations-and-qrisk2-scoring-in-uk-general-practice-a-thin-database-study
#5
Samuel Finnikin, Ronan Ryan, Tom Marshall
BACKGROUND: Statin prescribing should be based on cardiovascular disease (CVD) risk, but evidence suggests overtreatment of low-risk groups and undertreatment of high-risk groups. AIM: To investigate the relationship between CVD risk scoring in primary care and initiation of statins for the primary prevention of CVD, and the effect of changes to the National Institute for Health and Care Excellence (NICE) guidance in 2014. DESIGN AND SETTING: Historical cohort study using UK electronic primary care records...
October 23, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29048561/a-ca2-dependent-remodelled-actin-network-directs-vesicle-trafficking-to-build-wall-ingrowth-papillae-in-transfer-cells
#6
Hui-Ming Zhang, Kim Colyvas, John W Patrick, Christina E Offler, Simon Turner
The transport function of transfer cells is conferred by an enlarged plasma membrane area, enriched in nutrient transporters, that is supported on a scaffold of wall ingrowth (WI) papillae. Polarized plumes of elevated cytosolic Ca2+ define loci at which WI papillae form in developing adaxial epidermal transfer cells of Vicia faba cotyledons that are induced to trans-differentiate when the cotyledons are placed on culture medium. We evaluated the hypothesis that vesicle trafficking along a Ca2+-regulated remodelled actin network is the mechanism that underpins this outcome...
October 13, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29044586/males-with-prolactinoma-are-at-increased-risk-of-incident-cardiovascular-disease
#7
Konstantinos A Toulis, Tim Robbins, Narendra Reddy, Balachandran Kumarendran, Krishna Gokhale, Haren Wijesinghe, Kar Keung Cheng, Niki Karavitaki, John Wass, Krishnarajah Nirantharakumar
OBJECTIVE: To investigate whether the risk of incident cardiovascular disease (CVD) is increased in patients with prolactinoma. DESIGN: Population-based, retrospective, open-cohort study using The Health Improvement Network (THIN) database. PATIENTS: 2,233 patients with prolactinoma and 10,355 matched controls (1:5 ratio) from UK General Practices contributing to THIN were included. Sex, age, body mass index, and smoking status were used as matching parametres...
October 16, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29021576/the-recording-and-characteristics-of-pulmonary-rehabilitation-in-patients-with-copd-using-the-health-information-network-thin-primary-care-database
#8
Ali Hakamy, Tricia M McKeever, Jack E Gibson, Charlotte E Bolton
Pulmonary rehabilitation is recommended for patients with COPD to improve physical function, breathlessness and quality of life. Using The Health Information Network (THIN) primary care database in UK, we compared the demographic and clinical parameters of patients with COPD in relation to coding of pulmonary rehabilitation, and to investigate whether there is a survival benefit from pulmonary rehabilitation. We identified patients with COPD, diagnosed from 2004 and extracted information on demographics, pulmonary rehabilitation and clinical parameters using the relevant Read codes...
October 11, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/29017624/sociodemographic-inequalities-in-the-management-of-depression-in-adults-aged-55-and-over-an-analysis-of-english-primary-care-data
#9
K Walters, M Falcaro, N Freemantle, M King, Y Ben-Shlomo
BACKGROUND: We do not know how primary care treatment of depression varies by age across both psychotropic medication and psychological therapies. METHODS: Cohort study including 19 710 people aged 55+ with GP recorded depression diagnoses and 26 276 people with recorded depression symptoms during the period 2009-2013, from 373 General Practices in The Health Improvement Network (THIN) database in England. Main outcomes were initiation of treatment with anti-depressants, anxiolytics, hypnotics, anti-psychotic drugs, referrals to psychological therapies within 6 months of onset...
October 11, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28992917/the-use-of-large-databases-to-inform-the-development-of-an-intestinal-scoring-system-for-the-poultry-industry
#10
H Kasab-Bachi, A G Arruda, T E Roberts, J B Wilson
There is increasing interest among the poultry industry to develop a comprehensive index that can be used to evaluate overall intestinal health and impact on production performance. The Intestinal Integrity (I(2)) index is a quantitative measurement tool used to assess the intestinal health of flocks that use the Health Tracking System (HTSi), a global surveillance system developed by Elanco Animal Health that captures flock-level information on health and performance. To generate an I(2) index score for a flock, the presence of 23 intestinal health conditions is assessed and recorded, then entered into a mathematical equation...
October 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28977382/exploring-novel-diabetes-surveillance-methods-a-comparison-of-administrative-laboratory-and-pharmacy-data-case-definitions-using-thin
#11
Bushra Khokhar, Hude Quan, Gilaad G Kaplan, Sonia Butalia, Doreen Rabi
Background: The objective of this study was to identify patients with diabetes in a comprehensive primary care electronic medical records database using a number of different case definitions (clinical, pharmacy, laboratory definitions and a combination thereof) and understand the differences in patient populations being captured by each definition. Methods: Data for this population-based retrospective cohort study was obtained from The Health Information Network (THIN)...
July 28, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28964594/deconvolution-of-238-239-240-pu-conversion-electron-spectra-measured-with-a-silicon-drift-detector
#12
S Pommé, M Marouli, J Paepen, N Marković, R Pöllänen
Internal conversion electron (ICE) spectra of thin (238,239,240)Pu sources, measured with a windowless Peltier-cooled silicon drift detector (SDD), were deconvoluted and relative ICE intensities were derived from the fitted peak areas. Corrections were made for energy dependence of the full-energy-peak counting efficiency, based on Monte Carlo simulations. A good agreement was found with the theoretically expected internal conversion coefficient (ICC) values calculated from the BrIcc database.
September 13, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28963728/diagnostic-accuracy-of-ultrasound-in-detecting-the-severity-of-abnormally-invasive-placentation-a-systematic-review-and-meta-analysis
#13
REVIEW
Giorgio Pagani, Giuseppe Cali, Ganesh Acharya, Ilan Timor Trisch, Jose Palacios-Jaraquemada, Alessandra Familiari, Danilo Buca, Lamberto Manzoli, Maria Elena Flacco, Francesco Fanfani, Marco Liberati, Giovanni Scambia, Francesco D'Antonio
INTRODUCTION: Our objective was to elucidate the overall diagnostic accuracy of ultrasound in detecting the severity of abnormally invasive placentation (AIP). MATERIAL AND METHODS: Medline, Embase, CINAHL and The Cochrane databases were searched. The ultrasound signs explored were: loss of hypoechoic (clear) zone in the placental-uterine interface, placental lacunae, bladder wall interruption, myometrial thinning, focal exophitic mass, placental lacunar flow, sub-placental vascularity, and uterovescical hypervascularity...
September 30, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28958277/tumor-mitotic-rate-and-association-with-recurrence-in-sentinel-lymph-node-negative-stage-ii-melanoma-patients
#14
Shachar Laks, Michael O Meyers, Allison M Deal, Jill S Frank, Karyn B Stitzenberg, Jen Jen Yeh, Nancy E Thomas, David W Ollila
Tumor mitotic rate (TMR) is a known prognostic variable in thin melanoma patients. Its significance in stage II melanoma patients is yet to be demonstrated. Retrospective analysis of a prospective melanoma database from 9/1997 to 7/2015 was performed. All stage II melanoma, with documented TMR, and six months of follow-up were included. We evaluated the association of clinicopathologic variables, TMR, as a continuous and categorical variable with recurrence-free survival (RFS) and overall survival (OS) using Cox proportional hazards modeling...
September 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28954555/incidence-treatment-and-recurrence-of-endometriosis-in-a-uk-based-population-analysis-using-data-from-the-health-improvement-network-and-the-hospital-episode-statistics-database
#15
Lucia Cea Soriano, Esther López-Garcia, Renate Schulze-Rath, Luis A Garcia Rodríguez
PURPOSE: This retrospective study used medical records from The Health Improvement Network (THIN) and Hospital Episode Statistics (HES) database to evaluate endometriosis (incidence, treatment and need for recurrent invasive procedures) in the general UK population. MATERIALS AND METHODS: Women aged 12-54 years between January 2000 and December 2010, with a Read code for endometriosis, were identified in THIN. Cases were validated by manual review of free-text comments in medical records and responses to physician questionnaires...
September 28, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28951976/comparison-of-spatial-interpolation-methods-for-soil-moisture-and-its-application-for-monitoring-drought
#16
Hui Chen, Li Fan, Wei Wu, Hong-Bin Liu
Soil moisture data can reflect valuable information on soil properties, terrain features, and drought condition. The current study compared and assessed the performance of different interpolation methods for estimating soil moisture in an area with complex topography in southwest China. The approaches were inverse distance weighting, multifarious forms of kriging, regularized spline with tension, and thin plate spline. The 5-day soil moisture observed at 167 stations and daily temperature recorded at 33 stations during the period of 2010-2014 were used in the current work...
September 26, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28946908/factors-influencing-the-development-of-primary-care-data-collection-projects-from-electronic-health-records-a-systematic-review-of-the-literature
#17
Marie-Line Gentil, Marc Cuggia, Laure Fiquet, Camille Hagenbourger, Thomas Le Berre, Agnès Banâtre, Eric Renault, Guillaume Bouzille, Anthony Chapron
BACKGROUND: Primary care data gathered from Electronic Health Records are of the utmost interest considering the essential role of general practitioners (GPs) as coordinators of patient care. These data represent the synthesis of the patient history and also give a comprehensive picture of the population health status. Nevertheless, discrepancies between countries exist concerning routine data collection projects. Therefore, we wanted to identify elements that influence the development and durability of such projects...
September 25, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28945811/retinal-thinning-in-amyotrophic-lateral-sclerosis-patients-without-ophthalmic-disease
#18
Nisha Mukherjee, Shan McBurney-Lin, Anthony Kuo, Richard Bedlack, Henry Tseng
IMPORTANCE: Amyotrophic lateral sclerosis (ALS) is a fatal, rapidly progressive neurodegenerative disease that primarily affects motor neurons. Recently, three causative genes have been implicated in both ALS and glaucoma. However, it is still uncertain whether patients with ALS have neurodegeneration in their retinas. If so, retinal thickness measurements might be a useful biomarker for ALS progression. Previous work in this area has been inconclusive, as it has not taken into account the effect of ophthalmic diseases on retinal thinning...
2017: PloS One
https://www.readbyqxmd.com/read/28933880/media-exposure-in-very-young-girls-prospective-and-cross-sectional-relationships-with-bmiz-self-esteem-and-body-size-stereotypes
#19
Rachel F Rodgers, Stephanie R Damiano, Eleanor H Wertheim, Susan J Paxton
Media exposure among young children has been suggested to influence self-concept and the adoption of social stereotypes regarding body weight, as well as being associated with increased weight. The aim of this study was to examine the role of TV/DVD viewing in the development of positive stereotypes toward thinness, self-esteem and body mass index standardized for child age and gender (BMIz) in very young girls. A sample of 143 girls completed interviews at ages 3, 4, and 5 years old. The interviews assessed positive stereotypes about thinness among girls, as well as age 5 dietary restraint...
September 21, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28926469/a-survey-of-glucocorticoid-adverse-effects-and-benefits-in-rheumatic-diseases-the-patient-perspective
#20
Rachel J Black, Susan M Goodman, Carlee Ruediger, Susan Lester, Sarah L Mackie, Catherine L Hill
OBJECTIVE: The aim of this study was to explore, from the patient's perspective, the beneficial and adverse effects (AEs) of glucocorticoids (GCs) in patients with rheumatic diseases, to be used in the development of a patient-reported outcome measure. METHODS: A cross-sectional survey, capturing benefits and AEs of GC use, was administered to 2 groups of patients: (1) those attending a tertiary rheumatology clinic with various rheumatic diseases who had used GCs within the past year and (2) patients from the Hospital for Special Surgery rheumatoid arthritis database...
September 19, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
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