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https://www.readbyqxmd.com/read/28447620/dna-replication-licensing-factor-cdc6-and-plk4-kinase-antagonistically-regulate-centrosome-duplication-via-sas-6
#1
Xiaowei Xu, Shijiao Huang, Boyan Zhang, Fan Huang, Wangfei Chi, Jingyan Fu, Gang Wang, Si Li, Qing Jiang, Chuanmao Zhang
Centrosome number is tightly controlled during the cell cycle to ensure proper spindle assembly and cell division. However, the underlying mechanism that controls centrosome number remains largely unclear. We show herein that the DNA replication licensing factor Cdc6 is recruited to the proximal side of the centrioles via cyclin A to negatively regulate centrosome duplication by binding and inhibiting the cartwheel protein Sas-6 from forming a stable complex with another centriole duplication core protein, STIL...
April 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28447366/effects-of-dietary-lysine-levels-on-the-concentrations-of-selected-nutrient-metabolites-in-blood-plasma-of-late-stage-finishing-pigs
#2
N Regmi, T Wang, M A Crenshaw, B J Rude, S F Liao
Lysine is the first-limiting amino acid (AA) in typical swine diets and plays very important roles in promoting growth performance of pigs. This research was conducted to study the effects of dietary lysine on blood plasma concentrations of protein, carbohydrate, and lipid metabolites of pigs. Eighteen crossbred finishing pigs (nine barrows and nine gilts; initial BW 92.3 ± 6.9 kg) were individually penned in an environment controlled barn. Pigs were assigned to three dietary treatments according to a randomized complete block design with gender as block and pig as experimental unit (6 pigs/treatment)...
April 26, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28447032/risk-of-sleepiness-related-accidents-in-switzerland-results-of-an-online-sleep-apnea-risk-questionnaire-and-awareness-campaigns
#3
Mona Lichtblau, Daniel Bratton, Philippe Giroud, Thomas Weiler, Konrad E Bloch, Thomas Brack
OBJECTIVES: Obstructive sleep apnea syndrome (OSAS) is associated with major morbidity and mortality but OSAS is frequently under recognized. To promote awareness of OSAS, the Swiss Lung League launched an online questionnaire combined with annual advertisements in mass media. Characteristics of participants, prevalence of sleep apnea, OSAS-related symptoms, and their association with accidents were investigated. METHODS: A questionnaire was created incorporating anthropometrics, the Epworth sleepiness scale (ESS), the OSAS domain of the sleep disorders questionnaire (SDQ), and a question on accidents related to sleepiness...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28446193/liver-morphometrics-and-metabolic-blood-profile-across-divergent-phenotypes-for-feed-efficiency-in-the-bovine
#4
Yuri Regis Montanholi, Livia Sadocco Haas, Kendall Carl Swanson, Brenda Lee Coomber, Shigeto Yamashiro, Stephen Paul Miller
BACKGROUND: Feed costs are a major expense in the production of beef cattle. Individual variation in the efficiency of feed utilization may be evident through feed efficiency-related phenotypes such as those related to major energetic sinks. Our objectives were to assess the relationships between feed efficiency with liver morphometry and metabolic blood profile in feedlot beef cattle. METHODS: Two populations (A = 112 and B = 45) of steers were tested for feed efficiency...
April 26, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28445548/assessing-the-severity-of-sleep-apnea-syndrome-based-on-ballistocardiogram
#5
Zhu Wang, Xingshe Zhou, Weichao Zhao, Fan Liu, Hongbo Ni, Zhiwen Yu
BACKGROUND: Sleep Apnea Syndrome (SAS) is a common sleep-related breathing disorder, which affects about 4-7% males and 2-4% females all around the world. Different approaches have been adopted to diagnose SAS and measure its severity, including the gold standard Polysomnography (PSG) in sleep study field as well as several alternative techniques such as single-channel ECG, pulse oximeter and so on. However, many shortcomings still limit their generalization in home environment. In this study, we aim to propose an efficient approach to automatically assess the severity of sleep apnea syndrome based on the ballistocardiogram (BCG) signal, which is non-intrusive and suitable for in home environment...
2017: PloS One
https://www.readbyqxmd.com/read/28441459/cannabis-use-is-associated-with-reduced-prevalence-of-non-alcoholic-fatty-liver-disease-a-cross-sectional-study
#6
Adeyinka Charles Adejumo, Samson Alliu, Tokunbo Opeyemi Ajayi, Kelechi Lauretta Adejumo, Oluwole Muyiwa Adegbala, Nnaemeka Egbuna Onyeakusi, Akintunde Micheal Akinjero, Modupeoluwa Durojaiye, Terence Ndonyi Bukong
Cannabis use is associated with reduced prevalence of obesity and diabetes mellitus (DM) in humans and mouse disease models. Obesity and DM are a well-established independent risk factor for non-alcoholic fatty liver disease (NAFLD), the most prevalent liver disease globally. The effects of cannabis use on NAFLD prevalence in humans remains ill-defined. Our objective is to determine the relationship between cannabis use and the prevalence of NAFLD in humans. We conducted a population-based case-control study of 5,950,391 patients using the 2014 Healthcare Cost and Utilization Project (HCUP), Nationwide Inpatient Survey (NIS) discharge records of patients 18 years and older...
2017: PloS One
https://www.readbyqxmd.com/read/28440510/migration-of-oral-squamous-cell-carcinoma-cells-are-induced-by-hgf-c-met-signalling-via-lamellipodia-and-filopodia-formation
#7
Hiroki Yasui, Yuichi Ohnishi, Masahiro Nakajima, Masami Nozaki
The activation of receptor tyrosine kinases (RTKs) results in cellular effects including cell proliferation, survival, migration and invasion; RTKs also play an important role in tumourigenesis. It has been reported that EGFR signalling controls the migration of oral squamous cell carcinoma (OSCC) SAS and HSC3 cells but not of HSC4 cells, although the proliferation of HSC4 cells is regulated by EGF/EGFR. In the present study, we investigated the roles of EGFR and the c-Met signalling pathway in cell migration via filopodia and lamellipodia formation, which may be prerequisites for migration...
April 19, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28438434/connective-tissue-growth-factor-decreases-mitochondrial-metabolism-through-ubiquitin-mediated-degradation-of-mitochondrial-transcription-factor-a-in-oral-squamous-cell-carcinoma
#8
Wei-Ting Lai, Yue-Ju Li, Shi-Bei Wu, Cheng-Ning Yang, Tai-Sheng Wu, Yau-Huei Wei, Yi-Ting Deng
BACKGROUND/PURPOSE: Deregulation of metabolic pathways is one of the hallmarks of cancer progression. Connective tissue growth factor (CTGF/CCN2) acts as a tumor suppressor in oral squamous cell carcinoma (OSCC). However, the role of CTGF in modulating cancer metabolism is still unclear. METHODS: OSCC cells stably overexpressing CTGF (SAS/CTGF) and shRNA against CTGF (TW2.6/shCTGF) were established. Oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) were examined by the Seahorse XF24 analyzer...
April 21, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28435615/effect-of-zirconia-surface-treatment-using-nitric-acid-hydrofluoric-acid-on-the-shear-bond-strengths-of-resin-cements
#9
Jin Hyung Cho, Sun Jai Kim, June Sung Shim, Keun-Woo Lee
PURPOSE: The aim of this study was to compare the surface roughness of zirconia when using Zircos E etching system (ZSAT), applying a nitric acid-hydrofluoric acid compound as a pretreatment agent, and also to compare the shear bonding strength according to different resin cements. MATERIALS AND METHODS: ZSAT, air abrasion, and tribochemical silicacoating were applied on prepared 120 zirconia specimens (10 mm in diameter, 7 mm in height) using CAD/CAM. Each 12 specimens with 4 different resin cements (Panavia F 2...
April 2017: Journal of Advanced Prosthodontics
https://www.readbyqxmd.com/read/28435492/applying-systems-engineering-reduces-radiology-transport-cycle-times-in-the-emergency-department
#10
Benjamin A White, Brian J Yun, Michael H Lev, Ali S Raja
INTRODUCTION: Emergency department (ED) crowding is widespread, and can result in care delays, medical errors, increased costs, and decreased patient satisfaction. Simultaneously, while capacity constraints on EDs are worsening, contributing factors such as patient volume and inpatient bed capacity are often outside the influence of ED administrators. Therefore, systems engineering approaches that improve throughput and reduce waste may hold the most readily available gains. Decreasing radiology turnaround times improves ED patient throughput and decreases patient waiting time...
April 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28434725/effects-of-breed-feeding-system-and-lactation-stage-on-milk-fat-characteristics-and-spontaneous-lipolysis-in-dairy-cows
#11
E Vanbergue, L Delaby, J L Peyraud, S Colette, Y Gallard, C Hurtaud
Spontaneous lipolysis (SL) is an enzymatic reaction which leads to a release of free fatty acids that can modify technological and sensory properties of milk and milk products. However, few studies have been done to assess the effect of feeding systems (FS) and breed on SL. Most of them were conducted in the 1980s and are not fully representative of cattle today. No previous study investigated the effect of cow breed at the whole-lactation scale. Thus, a trial was carried out to study the effects of 2 FS (high- and low-input FS) with 2 breeds [Holstein (HO) and Normande (NO)] during 1 entire lactation...
April 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28434636/contralateral-metachronous-undescended-testis-is-it-predictable
#12
Madeline Cancian, Pamela Ellsworth, Anthony Caldamone
INTRODUCTION: Metachronous undescended testis (mcUDT), an acquired UDT after contralateral orchiopexy, can occur in some boys. If one were able to predict its occurrence, one might consider a proactive approach or at least one would be able to counsel the parents accordingly. Our hypothesis was there may be characteristics evident at the time of initial orchiopexy which could predict the development of contralateral mcUDT. OBJECTIVE: The aim was to Identify factors present at initial orchiopexy that predict development of subsequent mcUDT...
March 28, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28431532/residents-satisfaction-with-primary-medical-and-health-services-in-western-china
#13
Weinan Dong, Qingyu Zhang, Chunsheng Yan, Wanling Fu, Linlin Xu
BACKGROUND: Currently, China is in the process of medical and health care reform, and the establishment of primary medical and health services covering urban and rural residents is an important aspect of this process. Studying the satisfaction of residents of underdeveloped areas with their primary medical and health services and identifying the factors that can increase the satisfaction of different groups may improve patient compliance and ultimately improve health. Moreover, such research may provide a reference for the development of medical and health undertakings in similarly underdeveloped areas...
April 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28427334/the-impact-of-the-mode-of-survey-administration-on-estimates-of-daily-smoking-for-mobile-phone-only-users
#14
Joseph Hanna, Damien V Cordery, David G Steel, Walter Davis, Timothy C Harrold
BACKGROUND: Over the past decade, there have been substantial changes in landline and mobile phone ownership, with a substantial increase in the proportion of mobile-only households. Estimates of daily smoking rates for the mobile phone only (MPO) population have been found to be substantially higher than the rest of the population and telephone surveys that use a dual sampling frame (landline and mobile phones) are now considered best practice. Smoking is seen as an undesirable behaviour; measuring such behaviours using an interviewer may lead to lower estimates when using telephone based surveys compared to self-administered approaches...
April 20, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28425583/sleep-apnea-syndrome-inflammation-and-oxidative-stress-in-hemodialysis-patients
#15
Olga Nikitidou, Euphemia Daskalopoulou, Aikaterini Papagianni, Vassilios Liakopoulos, Aikaterini Michalaki, Foteini Christidou, Paraskevi Argyropoulou, Dimitrios Kirmizis, Georgios Efstratiadis, Pavlos Nikolaidis, Michail Daniilidis, Nicholas Dombros
INTRODUCTION: Sleep apnea syndrome (SAS) is an established cardiovascular risk factor in the general population related to inflammation and oxidative stress and is very common among hemodialysis patients. Cardiovascular disease and its complications is the main cause of death among hemodialysis patients. The aim of the present study was to investigate the role of SAS in the promotion of inflammation and oxidative stress and thus in the augmentation of cardiovascular risk in hemodialysis patients...
April 20, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28420368/outcomes-following-percutaneous-coronary-revascularization-among-south-asian-and-chinese-canadians
#16
Martha H Mackay, Robinder Singh, Robert H Boone, Julie E Park, Karin H Humphries
BACKGROUND: Previous data suggest significant ethnic differences in outcomes following percutaneous coronary revascularization (PCI), though previous studies have focused on subgroups of PCI patients or used administrative data only. We sought to compare outcomes in a population-based cohort of men and women of South Asian (SA), Chinese and "Other" ethnicity. METHODS: Using a population-based registry, we identified 41,792 patients who underwent first revascularization via PCI in British Columbia, Canada, between 2001 and 2010...
April 19, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28416323/review-of-coronary-subclavian-steal-syndrome
#17
REVIEW
Bennett Cua, Natasha Mamdani, David Halpin, Sunny Jhamnani, Sasanka Jayasuriya, Carlos Mena-Hurtado
The clinical benefits of using the left internal mammary artery (LIMA) to bypass the left anterior descending artery are well established making it the most frequently used conduit for coronary artery bypass surgery (CABG). Coronary subclavian steal syndrome (CSSS) occurs during left arm exertion when (1) the LIMA is used during bypass surgery and (2) there is a high grade (≥75%) left subclavian artery stenosis or occlusion proximal to the ostia of the LIMA resulting in "stealing" of the myocardial blood supply via retrograde flow up the LIMA graft to maintain left upper extremity perfusion...
April 14, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28411816/a-novel-metal-organic-framework-composite-mil-101-cr-go-as-an-efficient-sorbent-in-dispersive-micro-solid-phase-extraction-coupling-with-uhplc-ms-ms-for-the-determination-of-sulfonamides-in-milk-samples
#18
Xiuna Jia, Pan Zhao, Xiu Ye, Lianjun Zhang, Ting Wang, Qinyu Chen, Xiaohong Hou
As a novel material, metal-organic framework/graphite oxide (MIL-101(Cr)@GO) has great potential for the pretreatment of trace analytes. In the present study, MIL-101(Cr)@GO was synthesized using a solvothermal synthesis method at the nanoscale and was applied as sorbent in the dispersive micro-solid phase extraction (DMSPE) for the enrichment of the trace sulfonamides (SAs) from milk samples for the first time. Several experimental parameters including kinds of sorbents, the effect of pH, the amount of MIL-101(Cr)@GO, ionic strength, adsorption time, desorption solvent and desorption time were investigated...
July 1, 2017: Talanta
https://www.readbyqxmd.com/read/28410665/impact-of-dietary-precursor-ala-versus-preformed-dha-on-fatty-acid-profiles-of-eggs-liver-and-adipose-tissue-and-expression-of-genes-associated-with-hepatic-lipid-metabolism-in-laying-hens
#19
M Neijat, P Eck, J D House
Dietary omega-3 polyunsaturated fatty acids (n-3 PUFA), including alpha-linolenic acid (ALA) and preformed longer chain PUFA (LCPUFA, particularly docosahexaenoic acid, DHA) differ in their egg LCPUFA enrichment efficiency. However, mechanisms leading to these differences are unclear. To this end, omega-3 PUFA contents in different lipid classes, including triacylglycerol (TAG) and total phospholipid (PL) in yolk, liver and adipose, as well as the expression of key hepatic enzymes in lipid metabolism were evaluated in laying hens in response to changes in dietary supply...
April 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28408042/towards-the-determination-of-sulfonamides-in-meat-samples-a-magnetic-and-mesoporous-metal-organic-framework-as-an-efficient-sorbent-for-magnetic-solid-phase-extraction-combined-with-high-performance-liquid-chromatography
#20
Lian Xia, Lijie Liu, Xiaoxia Lv, Fei Qu, Guoliang Li, Jinmao You
A magnetic, mesoporous core/shell structured Fe3O4@JUC-48 nanocomposite was synthesized and employed as a magnetic solid phase extraction (MSPE) sorbent for the determination of trace sulfonamides (SAs) in meat samples. The synthesized nanocomposite was characterized by X-ray diffraction, Fourier transform infrared spectra, transmission electron microscopy, scanning electron microscopy, Brunner-Emmet-Teller, and vibrating sample magnetometry; the Fe3O4@JUC-48 nanocomposite exhibited a distinctive morphology, large surface area, high magnetism, open adsorption sites, and high chemical stability...
April 4, 2017: Journal of Chromatography. A
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