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https://www.readbyqxmd.com/read/28918559/prostate-cancer-screening-by-prostate-specific-antigen-psa-a-relevant-approach-for-the-small-population-of-the-cayman-islands
#1
Shravana Kumar Jyoti, Camille Blacke, Pallavi Patil, Vibha P Amblihalli, Amanda Nicholson
INTRODUCTION: The common tool for diagnosing prostate cancer is prostate-specific antigen (PSA), but the high sensitivity and low specificity of PSA testing are the problems in clinical practice. There are no proper guidelines to investigate the suspected prostate cancer in the Cayman Islands. We correlated PSA levels with the incidence of prostate cancers by tissue diagnosis and proposed logical protocol for prostate screening by using PSA test in this small population. MATERIALS AND METHODS: A total of 165 Afro Caribbean individuals who had prostate biopsy done after the investigations for PSA levels from year 2005 to 2015 were studied retrospectively...
September 16, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28916954/discrimination-and-mental-health-in-a-representative-sample-of-african-american-and-afro-caribbean-youth
#2
Lee M Pachter, Cleopatra H Caldwell, James S Jackson, Bruce A Bernstein
BACKGROUND: Racism and discrimination are psychosocial stressors that affect the health of minority populations. While discrimination has been associated with poor mental health, little is known about the relationship between discrimination and mental health outcomes in youth nationally. Furthermore, mental and behavioral health consequences of discrimination may differ in different minority groups. OBJECTIVE: The goal of this study is to determine (1) how common perceptions of discrimination are in a nationally representative sample of African-American (AA) and Afro-Caribbean (AC) teens, (2) the relationship between discrimination and mental health conditions, and (3) whether discrimination has different associations with mental health in AA and AC youth...
September 15, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28888591/aspre-trial-influence-of-compliance-on-beneficial-effect-of-aspirin-in-prevention-of-preterm-preeclampsia
#3
David Wright, Liona C Poon, Daniel L Rolnik, Argyro Syngelaki, Juan Luis Delgado, Denisa Vojtassakova, Mercedes de Alvarado, Evgenia Kapeti, Anoop Rehal, Andrea Pazos, Ilma Floriana Carbone, Vivien Dutemeyer, Walter Plasencia, Nikos Papantoniou, Kypros H Nicolaides
OBJECTIVE: To examine the influence of compliance on the beneficial effect of aspirin in prevention of preterm preeclampsia in the Combined Multimarker Screening and Randomized Patient Treatment with Aspirin for Evidence-Based Preeclampsia Prevention (ASPRE) trial. STUDY DESIGN: This was a secondary analysis of data from the ASPRE trial. In this multicenter-study women with singleton pregnancies had screening by means of an algorithm that combines maternal factors and biomarkers (mean arterial pressure, uterine-artery pulsatility index, and maternal serum pregnancy-associated plasma protein A and placental growth factor) at 11-13 weeks' gestation...
September 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28864878/self-rated-health-as-a-predictor-of-mid-term-and-long-term-mortality-in-older-afro-caribbeans-hospitalised-via-the-emergency-department
#4
Lidvine Godaert, C Godard-Sebillotte, L Allard Saint-Albin, L Bousquet, I Bourdel-Marchasson, J-L Fanon, M Dramé
PURPOSE: To determine whether self-rated health (SRH) is an independent predictor for mortality in older Afro-Caribbean patients hospitalised for an acute condition. METHODS: Prospective cohort of patients recruited from the University Hospitals of Martinique Acute Care for Elders unit. Patients aged 75 or older and hospitalised for an acute condition were eligible. The outcome was time to death within the 36-week follow-up. SRH was the explanatory variable of interest...
September 1, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28864839/outcomes-of-treatment-in-men-with-prostate-cancer-at-the-cancer-centre-bahamas
#5
Glenn Wayne Jones, Osama Kellini, Robin Roberts, Nevein Girgis, Chelsea Brown, Krista Nottage, Thomas McGowan, Corrine Sin Quee-Brown, Conville Brown
PURPOSE: This is a first report from The Bahamas of management and long-term outcomes in men with non-metastatic prostate cancer treated with radiotherapy, with or without androgen deprivation therapy, from 2004 to 2016. METHODS: Patients were characterized by baseline factors, stratified by risk groups using tumor stage (clinical T-stage), prostate-specific antigen (PSA) test result and Gleason grade, and sorted by treatment combinations (by radiation volume and use of androgen deprivation)...
September 1, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28853391/trends-in-the-burden-of-varicella-in-uk-general-practice
#6
J L Walker, N J Andrews, R Mathur, L Smeeth, S L Thomas
Childhood varicella vaccination has not yet been introduced in the UK. To inform decision-making about future vaccine programmes, data on the burden of varicella in general practice over a 10-year period (01/01/2005-31/12/2014) was calculated by age and ethnicity, using anonymised data from >8 million individuals in the Clinical Practice Research Datalink. Varicella consultations peaked at 20 603 in 2007, then decreased annually in all age groups to 11 243 in 2014. Each year, consultation rates were common among infants, were highest among 1-3 year olds (61·2 consultations/1000 person-years in 2007, 39·7/1000 person-years in 2014) and then fell with increasing age to <1·0/1000 person-years at ages ⩾20 years...
August 30, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28775045/prevalence-and-incidence-of-interstitial-lung-diseases-in-a-multi-ethnic-county-of-greater-paris
#7
Boris Duchemann, Isabella Annesi-Maesano, Camille Jacobe de Naurois, Shreosi Sanyal, Pierre-Yves Brillet, Michel Brauner, Marianne Kambouchner, Sophie Huynh, Jean Marc Naccache, Raphael Borie, Jacques Piquet, Arsène Mekinian, Jerôme Virally, Yurdagul Uzunhan, Jacques Cadranel, Bruno Crestani, Olivier Fain, Francois Lhote, Robin Dhote, Nathalie Saidenberg-Kermanac'h, Paul-André Rosental, Dominique Valeyre, Hilario Nunes
The objective of the study was to estimate the prevalence and incidence of interstitial lung diseases (ILDs) in Seine-Saint-Denis, a multi-ethnic county of Greater Paris, France.Patients with ILDs were identified between January and December 2012 by using several sources; all potentially involved medical specialists from public and private hospitals, community-based pulmonologists and general practitioners, and the Social Security system. Diagnoses were validated centrally by an expert multidisciplinary discussion...
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28774809/towards-diversity-in-genomics-the-emergence-of-neurogenomics-in-africa
#8
Emmanuel Quansah, Nathaniel W McGregor
There is a high burden of mental and neurological disorders in Africa. Nevertheless, there appears to be an under-representation of African ancestry populations in large-scale genomic studies. Here, we evaluated the extent of under-representation of Africans in neurogenomic studies in the GWAS Catalog. We found 569 neurogenomic studies, of which 88.9% were exclusively focused on people with European ancestry and the remaining 11.1% having African ancestry cases included. In terms of population, only 1.2% of the total populations involved in these 569 GWAS studies were of African descent...
August 1, 2017: Genomics
https://www.readbyqxmd.com/read/28730749/impact-of-the-dynamic-and-static-component-of-the-sport-practiced-for-electrocardiogram-analysis-in-screening-athletes
#9
Nicolas Maillot, Charles Guenancia, Nobila V Yameogo, Aurélie Gudjoncik, Fabien Garnier, Luc Lorgis, Frédéric Chagué, Yves Cottin
BACKGROUND: To interpret the electrocardiogram (ECG) of athletes, the recommendations of the ESC and the Seattle criteria define type-1 peculiarities, those induced by training, and type-2, those not induced by training, to rule out cardiomyopathy. The specificity of the screening was improved by Sheikh who definied "Refined Criteria", which includes a group of intermediate peculiarities. The aim of our study was to investigate the influence of static and dynamic components on the prevalence of different types of abnormalities...
July 21, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28727855/association-of-apoe-gene-polymorphism-with-lipid-profile-and-coronary-artery-disease-in-afro-caribbeans
#10
Laurent Larifla, Christophe Armand, Jacqueline Bangou, Anne Blanchet-Deverly, Patrick Numeric, Christiane Fonteau, Carl-Thony Michel, Séverine Ferdinand, Véronique Bourrhis, Fritz-Line Vélayoudom-Céphise
OBJECTIVES: Apolipoprotein E gene (APOE) polymorphism is associated with the lipid profile and cardio-vascular disease. However, these relationships vary between ethnic groups. We evaluated, for the first time in an Afro-Caribbean population, the distribution of APOE polymorphisms and their associations with coronary artery disease (CAD), the lipid profile and other cardio-metabolic risk factors. METHODS: We studied 712 Afro-Caribbean subjects including 220 with documented CAD and 492 healthy subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28704120/association-of-physical-activity-with-alcohol-abuse-and-dependence-in-a-nationally-representative-u-s-sample
#11
April Joy Damian, Tamar Mendelson
BACKGROUND: Alcohol use is a pervasive and costly public health problem in the United States. Relapse rates from alcohol use disorders are high. Although exercise has been proposed as a strategy to prevent relapse, lifestyle modification is the least studied aspect of relapse prevention programs, especially among racial/ethnic minority populations. OBJECTIVE: The current study assessed whether being physically active was associated with remission from alcohol abuse or dependence among Black (African American and Afro Caribbean) adults in the U...
July 13, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28674508/-it-s-just-more-acceptable-to-be-white-or-mixed-race-and-gay-than-black-and-gay-the-perceptions-and-experiences-of-homophobia-in-st-lucia
#12
Jimmy Couzens, Berenice Mahoney, Dean Wilkinson
Lesbian, gay, and bisexual (LGB) individuals come from diverse cultural groups with differing ethnic and racial identities. However, most research on LGB people uses white western samples and studies of Afro-Caribbean diaspora often use Jamaican samples. Thus, the complexity of Afro-Caribbean LGB peoples' experiences of homophobia is largely unknown. The authors' analyses explore experiences of homophobia among LGB people in St. Lucia. Findings indicate issues of skin-shade orientated tolerance, regionalized disparities in levels of tolerance toward LGB people and regionalized passing (regionalized sexual identity shifting)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28648733/-is-transplantation-an-alternative-to-the-transfusional-impasse-in-sickle-cell-disease
#13
F Bernaudin, M Kuentz
Sickle cell disease is the most frequent genetic disease in France, concerning 400 newborns each year. The management of these Afro-Caribbean patients requires frequent transfusions from Caucasian donors. Due to important erythroid antigenic differences between Caucasian and African, the prevalence of allo-immunization is high in this population with a risk of transfusional impasse. Allogeneic stem cell transplantation is the only curative treatment for this disease and the replacement of red cells and lymphocytes of the sickle cell patient by those of the donor can also resolve the transfusional impasse...
June 22, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28638605/effect-of-ethnicity-and-socioeconomic-status-on-vascular-access-provision-and-performance-in-an-urban-nhs-hospital
#14
Teun Wilmink, Anika Wijewardane, Kathryn Lee, Alexander Murley, Lee Hollingworth, Sarah Powers, Jyoti Baharani
BACKGROUND: The aim of this study was to examine the effect of ethnicity, socioeconomic group (SEG) and comorbidities on provision of vascular access for haemodialysis (HD). METHODS: This was a retrospective review of two databases of HD sessions and access operations from 2003-11. Access modality of first HD session and details of transplanted patients were derived from the renal database. Follow-up was until 1 January 2015. Primary failure (PF) was defined as an arteriovenous fistula (AVF) used for fewer than six consecutive dialysis sessions...
February 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28637889/targeted-metabolomics-demonstrates-distinct-and-overlapping-maternal-metabolites-associated-with-bmi-glucose-and-insulin-sensitivity-during-pregnancy-across-four-ancestry-groups
#15
Saya Jacob, Michael Nodzenski, Anna C Reisetter, James R Bain, Michael J Muehlbauer, Robert D Stevens, Olga R Ilkayeva, Lynn P Lowe, Boyd E Metzger, Christopher B Newgard, Denise M Scholtens, William L Lowe
OBJECTIVE: We used targeted metabolomics in pregnant mothers to compare maternal metabolite associations with maternal BMI, glycemia, and insulin sensitivity. RESEARCH DESIGN AND METHODS: Targeted metabolomic assays of clinical metabolites, amino acids, and acylcarnitines were performed on fasting and 1-h postglucose serum samples from European ancestry, Afro-Caribbean, Thai, and Mexican American mothers (400 from each ancestry group) who participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and underwent an oral glucose tolerance test at ∼28 weeks gestation...
July 2017: Diabetes Care
https://www.readbyqxmd.com/read/28637888/maternal-bmi-and-glycemia-impact-the-fetal-metabolome
#16
William L Lowe, James R Bain, Michael Nodzenski, Anna C Reisetter, Michael J Muehlbauer, Robert D Stevens, Olga R Ilkayeva, Lynn P Lowe, Boyd E Metzger, Christopher B Newgard, Denise M Scholtens
OBJECTIVE: We used targeted metabolomics to determine associations of maternal BMI and glucose levels with cord blood metabolites and associations of cord blood metabolites with newborn birth weight and adiposity in mother-offspring dyads. RESEARCH DESIGN AND METHODS: Targeted metabolomic assays were performed on cord blood serum samples from European ancestry, Afro-Caribbean, Thai, and Mexican American newborns (400 from each ancestry group) whose mothers participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and who had anthropometric measurements at birth...
July 2017: Diabetes Care
https://www.readbyqxmd.com/read/28629668/underestimating-the-size-of-the-problem-uk-anaesthesia-for-patients-with-obesity
#17
James Palmer, Mike Sury, Claire Nightingale, Jaideep Pandit, Tim Cook
We analysed data from 14,000 patients in the 2013 United Kingdom Anaesthesia Activity Survey of the Fifth National Audit Project of the Royal College of Anaesthetists and Association of Anaesthetists of Great Britain and Ireland to examine anaesthetic, organisational and clinical practice for patients with obesity. We compared practice then with current guidance on management of this patient group. Obesity was reported in 22%, mainly Black, Afro-Caribbean and White Caucasian patients. There was minimal variation in surgical timing, anaesthetic seniority, induction location or day-case procedure rates...
June 16, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28576421/-impact-of-gleason-score-on-biochemical-recurrence-free-survival-after-radical-prostatectomy-with-positive-surgical-margins
#18
V Roux, R Eyraud, L Brureau, G Gourtaud, C Senechal, M Fofana, P Blanchet
PURPOSE: Research of predictive factors of biochemical recurrence to guide the establishment of an adjuvant treatment after radical prostatectomy for cancer with positive surgical margins. METHODOLOGY: A retrospective cohort of 1577 afro-caribbean patients undergoing radical prostatectomy operated between 1st January 2000 and 1st July 2013 was analyzed. In this cohort, 406 patients had positive surgical margin, we excluded 11 patients who received adjuvant therapy (radiotherapy, hormonotherapy, radio-hormonotherapy) and 2 patients for whom histological analysis of the surgical specimen was for a pT4 pathological stage...
June 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28555188/educational-health-disparities-in-cardiovascular-disease-risk-factors-findings-from-jamaica-health-and-lifestyle-survey-2007-2008
#19
Trevor S Ferguson, Novie O M Younger-Coleman, Marshall K Tulloch-Reid, Ian R Hambleton, Damian K Francis, Nadia R Bennett, Shelly R McFarlane, Aurelian Bidulescu, Marlene Y MacLeish, Anselm J M Hennis, Rainford J Wilks, E Nigel Harris, Louis W Sullivan
OBJECTIVES: Socioeconomic disparities in health have emerged as an important area in public health, but studies from Afro-Caribbean populations are uncommon. In this study, we report on educational health disparities in cardiovascular disease (CVD) risk factors (hypertension, diabetes mellitus, hypercholesterolemia, and obesity), among Jamaican adults. METHODS: We analyzed data from the Jamaica Health and Lifestyle Survey 2007-2008. Trained research staff administered questionnaires and obtained measurements of blood pressure, anthropometrics, glucose and cholesterol...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28543620/squamous-cell-carcinoma-in-the-afro-caribbean-community-an-11-year-retrospective-study
#20
N Cordel, L Bonnecarrère, B Tressières
BACKGROUND: Squamous cell carcinoma (SCC) is considered the most frequent skin cancer in Black people. Its incidence is not known in the Afro-Caribbean population. OBJECTIVE: To assess the incidence of SCC in Guadeloupe, the largest island of the Lesser Antilles (405 000 inhabitants, mostly Black people of African and European descent). The second objective was to characterize clinical and histological patterns of SCC occurring in the Afro-Caribbean community. METHODS: This retrospective study was conducted over an 11-year period (2000-2010)...
May 22, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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