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https://www.readbyqxmd.com/read/28167416/the-relationship-between-ethnicity-social-deprivation-and-late-presentation-of-colorectal-cancer
#1
Alan Askari, Subramanian Nachiappan, Andrew Currie, Andrew Latchford, Justin Stebbing, Alex Bottle, Thanos Athanasiou, Omar Faiz
INTRODUCTION: Tumour staging at time of presentation is an important factor in determining survival in colorectal cancer. The aim of this paper is to investigate the relationship between ethnicity and deprivation in late (Stage IV) presentation of colorectal cancer. METHODS: Data from the Thames Cancer Registry comprising 77,057 colorectal cancer patients between the years 2000 and 2012 were analysed. RESULTS: A total of 17,348 patients were identified with complete data, of which 53...
February 3, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28153016/lack-of-association-between-polymorphism-rs540782-and-primary-open-angle-glaucoma-in-saudi-patients
#2
Altaf A Kondkar, Nikhil B Edward, Hatem Kalantan, Abdullah S Al-Kharashi, Saleh Altuwaijri, Gamal Mohamed, Tahira Sultan, Taif A Azad, Khaled K Abu-Amero
BACKGROUND: To investigate whether polymorphism rs540782 on chromsome 1, in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene, is a risk factor for primary open angle glaucoma (POAG). METHOD: The study genotyped 92 unrelated POAG cases and 95 control subjects from Saudi Arabia using Taq-Man® assay. RESULTS: The genotype frequency distribution did not deviate significantly from the Hardy-Weinberg equilibrium (p > 0.05)...
February 2, 2017: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/28149384/effects-of-ethnicity-on-the-relationship-between-vertical-jump-and-maximal-power-on-a-cycle-ergometer
#3
Majdi Rouis, Laure Coudrat, Hamdi Jaafar, Elvis Attiogbé, Henry Vandewalle, Tarak Driss
The aim of this study was to verify the impact of ethnicity on the maximal power-vertical jump relationship. Thirty-one healthy males, sixteen Caucasian (age: 26.3 ± 3.5 years; body height: 179.1 ± 5.5 cm; body mass: 78.1 ± 9.8 kg) and fifteen Afro-Caribbean (age: 24.4 ±2.6 years; body height: 178.9 ± 5.5 cm; body mass: 77.1 ± 10.3 kg) completed three sessions during which vertical jump height and maximal power of lower limbs were measured. The results showed that the values of vertical jump height and maximal power were higher for Afro-Caribbean participants (62...
June 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28134031/factors-that-influence-clinicians-decisions-to-offer-intravenous-alteplase-in-acute-ischemic-stroke-patients-with-uncertain-treatment-indication-results-of-a-discrete-choice-experiment
#4
Aoife De Brún, Darren Flynn, Laura Ternent, Christopher I Price, Helen Rodgers, Gary A Ford, Matthew Rudd, Emily Lancsar, Stephen Simpson, John Teah, Richard G Thomson
Background Treatment with intravenous alteplase for eligible patients with acute ischemic stroke is underused, with variation in treatment rates across the UK. This study sought to elucidate factors influencing variation in clinicians' decision-making about this thrombolytic treatment. Methods A discrete choice experiment using hypothetical patient vignettes framed around areas of clinical uncertainty was conducted with UK-based clinicians. Mixed logit regression analyses were conducted on the data. Results A total of 138 clinicians completed the discrete choice experiment...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28118527/from-childhood-to-adulthood-the-trajectory-of-damage-in-patients-with-childhood-onset-systemic-lupus-erythematosus
#5
Lily Sh Lim, Eleanor Pullenayegum, Lillian Lim, Dafna Gladman, Brian Feldman, Earl Silverman
Objectives 1) To determine the longitudinal damage trajectory of patients with childhood-onset SLE (cSLE). 2) To identify baseline and disease course predictors of damage trajectory. Methods This is a retrospective inception cohort. Longitudinal pediatric-age data was obtained from a cSLE research database while adult-age data was obtained from either a research database or patients' charts. Baseline factors were tested as predictors. Time-varying factors were lagged 6 to 24 months before a visit for testing their predictive effects...
January 24, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/27966789/the-black-dentist-workforce-in-the-united-states
#6
Elizabeth Mertz, Jean Calvo, Cynthia Wides, Paul Gates
OBJECTIVES: The purpose of this paper is to describe the Black dentist workforce, the practice patterns of providers, and their contributions to oral health care for minority and underserved patients. METHODS: A national sample survey of underrepresented minority dentists was conducted in 2012 and received a 32.6 percent response rate for self-reported Black dentists. Data were weighted for selection and response bias to be nationally representative. Descriptive and multivariable statistics were computed to provide a workforce profile of Black dentists...
December 14, 2016: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/27940591/granulomatosis-with-polyangiitis-according-to-geographic-origin-and-ethnicity-clinical-biological-presentation-and-outcome-in-a-french-population
#7
Benjamin Terrier, Agnès Dechartres, Christophe Deligny, Pascal Godmer, Pierre Charles, Gilles Hayem, Bertrand Dunogué, Michel de Bandt, Pascal Cohen, Xavier Puéchal, Claire Le Jeunne, Serge Arfi, Luc Mouthon, Loïc Guillevin
OBJECTIVES: Granulomatosis with polyangiitis (GPA) mainly affects white Europeans, but rarely GPA may also affect non-Europeans. This study aimed to describe GPA clinical-biological presentation and outcome in black sub-Saharan Africans and Afro-Caribbeans and in North Africans. METHODS: Among 914 GPA patients included in the French Vasculitis Study Group database, geographic origin and ethnicity were known for 760. Clinical-biological presentations and outcomes of white Europeans vs black sub-Saharans and Afro-Caribbeans and vs North Africans were analysed...
December 10, 2016: Rheumatology
https://www.readbyqxmd.com/read/27930355/premature-cardiac-aging-in-south-asian-compared-to-afro-caribbean-subjects-in-a-community-based-screening-study
#8
Eduard Shantsila, Alena Shantsila, Paramjit S Gill, Gregory Y H Lip
BACKGROUND: People of South Asian (SAs) and African Caribbean (AC) origin have increased cardiovascular morbidity, but underlying mechanisms are poorly understood. Aging is the key predictor of deterioration in diastolic function, which can be assessed by echocardiography using E/e' ratio as a surrogate of left ventricular (LV) filling pressure. The study aimed to assess a possibility of premature cardiac aging in SA and AC subjects. METHODS AND RESULTS: We studied 4540 subjects: 2880 SA and 1660 AC subjects...
November 10, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27864990/the-clinical-relevance-of-antifibrillarin-anti-u3-rnp-autoantibodies-in-systemic-sclerosis
#9
F Tall, M Dechomet, S Riviere, V Cottin, E Ballot, K P Tiev, R Montin, C Morin, Y Chantran, C Grange, D Jullien, J Ninet, P Chretien, J Cabane, N Fabien, C Johanet
Systemic sclerosis (SSc) is a heterogeneous autoimmune disease associated with several antinuclear autoantibodies useful to diagnosis and prognosis. The aim of the present multicentric study was to determine the clinical relevance of antifibrillarin autoantibodies (AFA) in patients with SSc. The clinical features of 37 patients with SSc positive for AFA (AFA+) and 139 SSc patients without AFA (AFA-) were collected retrospectively from medical records to enable a comparison between AFA- and AFA+ patients. Antifibrillarin autoantibodies were screened by an indirect immunofluorescence technique using HEp2 cells and identified by an in-house Western blot technique and/or an EliA test...
January 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27837412/skin-bleaching-and-dermatologic-health-of-african-and-afro-caribbean-populations-in-the-us-new-directions-for-methodologically-rigorous-multidisciplinary-and-culturally-sensitive-research
#10
Emma K T Benn, Andrew Alexis, Nihal Mohamed, Yan-Hong Wang, Ikhlas A Khan, Bian Liu
Skin-bleaching practices, such as using skin creams and soaps to achieve a lighter skin tone, are common throughout the world and are triggered by cosmetic reasons that oftentimes have deep historical, economic, sociocultural, and psychosocial roots. Exposure to chemicals in the bleaching products, notably, mercury (Hg), hydroquinone, and steroids, has been associated with a variety of adverse health effects, such as Hg poisoning and exogenous ochronosis. In New York City (NYC), skin care product use has been identified as an important route of Hg exposure, especially among Caribbean-born blacks and Dominicans...
December 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/27836651/magnetic-resonance-imaging-characteristics-of-ischemic-stroke-in-an-afro-caribbean-population-a-1-year-prospective-mri-study-on-534%C3%A2-consecutive-patients
#11
M Mejdoubi, A Signate, S Colombani, A Arrigo, S Olindo
PURPOSES: Few population-based MRI studies on stroke, particularly in African-descent populations, are available. Based on a 1-year Afro-Caribbean population-based study MRI, ischemic stroke characteristics were extensively analyzed. METHODS: All strokes occurring in Martinique (390,371 inhabitants) were prospectively included. Ascertainment was based, whenever possible, on MRI. All patients were categorized as single- (subclassified as cortical, cortical-subcortical, subcortical, lacunar) or multiple-lesion pattern, and vascular (single, multiple or junctional) territory...
November 8, 2016: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/27825567/prevalence-of-rheumatoid-arthritis-in-the-french-west-indies-results-of-the-epppra-study-in-martinique
#12
Lauren Brunier, Marie Bleterry, Sylvie Merle, Christian Derancourt, Katlyn Polomat, Véronique Dehlinger, Christophe Deligny, Georges Jean-Baptiste, Serge Arfi, Rishika Banydeen, Michel De Bandt
OBJECTIVES: Studies suggest that rheumatoid arthritis (RA) is less frequent in African populations. However, no recent precise data exists for Afro-Caribbeans. The EPPPRA project is a prospective epidemiological survey to describe prevalence and clinical aspects of RA in the French West Indies (Martinique, Guadeloupe, French Guiana). METHODS: EPPPRA involved all rheumatologists from the French West Indies who included all patients with a known clinical diagnosis of RA, during a one-year period...
November 4, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27806729/hematological-reference-intervals-determination-in-adults-at-gondar-university-hospital-northwest-ethiopia
#13
Aregawi Yalew, Betelihem Terefe, Meseret Alem, Bamlaku Enawgaw
BACKGROUND: Hematological reference values are important for the clinical decisions in laboratory diagnosis and monitoring of patients. The correct interpretation of laboratory results depends entirely on the reference intervals that have been established for the locality. But, in sub-Saharan African countries particularly in Ethiopia, locally derived reference intervals were not established and they are forced to use intervals established from western population. Thus this study aimed to establish locally derived hematological reference values that could be used in Northwest Ethiopia...
November 2, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27791248/ethnic-variation-in-vitreoretinal-surgery-differences-in-clinical-presentation-and-outcome
#14
Bhaskar Gupta, James E Neffendorf, Roger Wong, David A H Laidlaw, Tom H Williamson
PURPOSE: The true prevalence of retinal detachment and other vitreoretinal disorders in different ethnic groups is not well-established. Understanding differences in vitreoretinal disease prevalence is important to appropriately allocate resources to meet demand where ethnic variation in the community exists. The aim of this study is to provide hospital-based data on the proportion of people with vitreoretinal disorders in the 3 main ethnic groups in the United Kingdom: Caucasian, Afro-Caribbean, and South Asian...
October 22, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/27764826/normal-range-of-fetal-nasal-bone-length-during-the-second-trimester-in-an-afro-caribbean-population-and-likelihood-ratio-for-trisomy-21-of-absent-or-hypoplastic-nasal-bone
#15
Manuella Gautier, Michèle Gueneret, Corinne Plavonil, Eugénie Jolivet, Bruno Schaub
OBJECTIVE: To establish the normal reference range of fetal nasal bone length (NBL) during the second trimester in an Afro-Caribbean population and the likelihood ratio (LR) for fetal trisomy 21. METHODS: Prenatal records of euploid, non-malformed singleton fetuses who underwent second-trimester ultrasonographic scans at 20-24 weeks of gestation were retrospectively analyzed for NBL and gestational age (GA). Only Afro-Caribbean couples were selected. The relationship between fetal NBL and GA was determined...
October 21, 2016: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/27684940/gene-polymorphisms-of-fabp2-adipoq-and-anp-and-risk-of-hypertriglyceridemia-and-metabolic-syndrome-in-afro-caribbeans
#16
Laurent Larifla, Christine Rambhojan, Marie-Odile Joannes, Suliya Maimaitiming-Madani, Jean-Paul Donnet, Thérèse Marianne-Pépin, Roger Chout, Ronan Roussel, Lydia Foucan
OBJECTIVES: The metabolic syndrome (MetS) is a cluster of metabolic abnormalities and cardiovascular risk factors that are highly heritable and polygenic. We investigated the association of allelic variants of three candidate genes, rs1799883-FABP2, rs1501299-ADIPOQ and rs5065-ANP with MetS and its components, individually and in combination, using a genetic risk score. METHODS: A cross-sectional study was conducted in 462 Afro-Caribbeans subjects without cardiovascular complications or lipid-lowering medications...
2016: PloS One
https://www.readbyqxmd.com/read/27679836/comparison-of-hypertrophic-cardiomyopathy-in-afro-caribbean-versus-white-patients-in-the-uk
#17
Nabeel Sheikh, Michael Papadakis, Vasileios F Panoulas, Keerthi Prakash, Lynne Millar, Paolo Adami, Abbas Zaidi, Sabiha Gati, Mathew Wilson, Gerald Carr-White, Maria Teresa Esteban Tomé, Elijah R Behr, Sanjay Sharma
BACKGROUND: This study investigated the influence of African/Afro-Caribbean (black) ethnicity on the clinical profile and outcomes in hypertrophic cardiomyopathy (HCM). METHODS: 425 consecutive patients with HCM (163 black and 262 Caucasians (white); mean age 52.5±16.6 years) were assessed at three cardiomyopathy centres. Repeat assessments were performed every 6-12 months and mean follow-up was 4.3±3.0 years. The primary outcome was a composite of cardiovascular death, cardiac arrest or appropriate device therapy...
September 27, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27679750/personalized-medicine-in-ocular-fibrosis-myth-or-future-biomarkers
#18
REVIEW
Cynthia Yu-Wai-Man, Peng Tee Khaw
Significance: Fibrosis-related events play a part in the pathogenesis or failure of treatment of virtually all the blinding diseases around the world, and also account for over 40% of all deaths. It is well established that the eye and other tissues of some group of patients, for example Afro-Caribbean people, scar worse than others. However, there is a current lack of reliable biomarkers to stratify the risk of scarring and postsurgical fibrosis in the eye. Recent Advances: Recent studies using genomics, proteomics, metabolomics, clinical phenotyping, and high-resolution in vivo imaging techniques have revealed potential novel biomarkers to identify and stratify patients at risk of scarring in different fibrotic eye diseases...
September 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27666405/asthma-in-children-of-caribbean-descent-living-in-the-inner-city-comparing-puerto-rican-and-afro-caribbean-children
#19
Dara M Steinberg, Denise Serebrisky, Jonathan M Feldman
Ethnic minority children bear a disproportionate amount of the US asthma burden. We compared asthma morbidity and pulmonary function (%FEV1) in two Caribbean groups living in the Bronx, NY: Puerto Rican and Afro-Caribbean children. Caregiver-child dyads (Puerto Rican: n = 113, M age = 9.89 ± 2.05; Afro-Caribbean: n = 47, Mage = 10.35 ± 2.08) responded to sociodemographic and asthma-related questions, and children's %FEV1 was measured. Puerto Rican children had significantly greater (past year) asthma morbidity, yet there were no significant differences in %FEV1...
September 25, 2016: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/27625379/association-between-carotid-bulb-diaphragm-and-ischemic-stroke-in-young-afro-caribbean-patients-a-population-based-case-control-study
#20
Julien Joux, Marion Boulanger, Severine Jeannin, Nicolas Chausson, Jean-Luc Hennequin, Vincent Molinié, Didier Smadja, Emmanuel Touzé, Stephane Olindo
BACKGROUND AND PURPOSE: Carotid bulb diaphragm (CBD) has been described in young carotid ischemic stroke (CIS) patients, especially in blacks. However, the prevalence of CBD in CIS patients is unknown, and whether CBD is a risk factor for CIS remains unclear. We assessed the association between CBD and incident CIS in a population-based study. METHODS: We selected all young (<55 years) CIS patients from a 1-year population-based cohort study in the Afro-Caribbean population of Martinique in 2012...
October 2016: Stroke; a Journal of Cerebral Circulation
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