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Manuella Gautier, Michèle Gueneret, Corinne Plavonil, Eugénie Jolivet, Bruno Schaub
OBJECTIVE: To establish the normal reference range of fetal nasal bone length (NBL) during the second trimester in an Afro-Caribbean population and the likelihood ratio (LR) for fetal trisomy 21. METHODS: Prenatal records of euploid, non-malformed singleton fetuses who underwent second-trimester ultrasonographic scans at 20-24 weeks of gestation were retrospectively analyzed for NBL and gestational age (GA). Only Afro-Caribbean couples were selected. The relationship between fetal NBL and GA was determined...
October 21, 2016: Fetal Diagnosis and Therapy
Laurent Larifla, Christine Rambhojan, Marie-Odile Joannes, Suliya Maimaitiming-Madani, Jean-Paul Donnet, Thérèse Marianne-Pépin, Roger Chout, Ronan Roussel, Lydia Foucan
OBJECTIVES: The metabolic syndrome (MetS) is a cluster of metabolic abnormalities and cardiovascular risk factors that are highly heritable and polygenic. We investigated the association of allelic variants of three candidate genes, rs1799883-FABP2, rs1501299-ADIPOQ and rs5065-ANP with MetS and its components, individually and in combination, using a genetic risk score. METHODS: A cross-sectional study was conducted in 462 Afro-Caribbeans subjects without cardiovascular complications or lipid-lowering medications...
2016: PloS One
Nabeel Sheikh, Michael Papadakis, Vasileios F Panoulas, Keerthi Prakash, Lynne Millar, Paolo Adami, Abbas Zaidi, Sabiha Gati, Mathew Wilson, Gerald Carr-White, Maria Teresa Esteban Tomé, Elijah R Behr, Sanjay Sharma
BACKGROUND: This study investigated the influence of African/Afro-Caribbean (black) ethnicity on the clinical profile and outcomes in hypertrophic cardiomyopathy (HCM). METHODS: 425 consecutive patients with HCM (163 black and 262 Caucasians (white); mean age 52.5±16.6 years) were assessed at three cardiomyopathy centres. Repeat assessments were performed every 6-12 months and mean follow-up was 4.3±3.0 years. The primary outcome was a composite of cardiovascular death, cardiac arrest or appropriate device therapy...
September 27, 2016: Heart: Official Journal of the British Cardiac Society
Cynthia Yu-Wai-Man, Peng Tee Khaw
Significance: Fibrosis-related events play a part in the pathogenesis or failure of treatment of virtually all the blinding diseases around the world, and also account for over 40% of all deaths. It is well established that the eye and other tissues of some group of patients, for example Afro-Caribbean people, scar worse than others. However, there is a current lack of reliable biomarkers to stratify the risk of scarring and postsurgical fibrosis in the eye. Recent Advances: Recent studies using genomics, proteomics, metabolomics, clinical phenotyping, and high-resolution in vivo imaging techniques have revealed potential novel biomarkers to identify and stratify patients at risk of scarring in different fibrotic eye diseases...
September 1, 2016: Advances in Wound Care
Dara M Steinberg, Denise Serebrisky, Jonathan M Feldman
Ethnic minority children bear a disproportionate amount of the US asthma burden. We compared asthma morbidity and pulmonary function (%FEV1) in two Caribbean groups living in the Bronx, NY: Puerto Rican and Afro-Caribbean children. Caregiver-child dyads (Puerto Rican: n = 113, M age = 9.89 ± 2.05; Afro-Caribbean: n = 47, Mage = 10.35 ± 2.08) responded to sociodemographic and asthma-related questions, and children's %FEV1 was measured. Puerto Rican children had significantly greater (past year) asthma morbidity, yet there were no significant differences in %FEV1...
September 25, 2016: Psychology, Health & Medicine
Julien Joux, Marion Boulanger, Severine Jeannin, Nicolas Chausson, Jean-Luc Hennequin, Vincent Molinié, Didier Smadja, Emmanuel Touzé, Stephane Olindo
BACKGROUND AND PURPOSE: Carotid bulb diaphragm (CBD) has been described in young carotid ischemic stroke (CIS) patients, especially in blacks. However, the prevalence of CBD in CIS patients is unknown, and whether CBD is a risk factor for CIS remains unclear. We assessed the association between CBD and incident CIS in a population-based study. METHODS: We selected all young (<55 years) CIS patients from a 1-year population-based cohort study in the Afro-Caribbean population of Martinique in 2012...
October 2016: Stroke; a Journal of Cerebral Circulation
Cécile Faure, Keyne Charlot, Stéphane Henri, Marie-Dominique Hardy-Dessources, Olivier Hue, Sophie Antoine-Jonville
OBJECTIVE: The effect of physical activity on food intake regulation may be moderated by environmental temperature. The aim of the study was to determine the single and combined effects of metabolic activity and temperature on energy intake and its hormonal regulation. METHODS: A randomized crossover study was conducted in the laboratory. Ten healthy and physically active young Afro-Caribbean men participated in four experimental sessions (rest at 22°C and 31°C and cycling at 60% of their maximal oxygen uptake at 22°C and 31°C, all for 40 min)...
October 2016: Metabolism: Clinical and Experimental
Jason N Dungu, Sofia A Papadopoulou, Katharine Wykes, Ihtisham Mahmood, Joseph Marshall, Oswaldo Valencia, Marianna Fontana, Carol J Whelan, Julian D Gillmore, Philip N Hawkins, Lisa J Anderson
BACKGROUND: It has been reported that subjects of African descent present with heart failure at a younger age and because of different causes than whites. We present contemporary data from UK Afro-Caribbean patients in London. METHODS AND RESULTS: All patients with heart failure presenting to St George's Hospital Heart Failure clinic between 2005 and 2012 were included (n=1392). Patients were predominantly white (71%) and male (67%), and median age at presentation was 73 years (range, 18-100 years)...
September 2016: Circulation. Heart Failure
K Zhaorong-Wang, D Cohall, T Scantlebury-Manning
Objective: To evaluate undergraduate students' sodium and potassium intake, and perceptions toward these parameters and their cardiovascular health at The University of the West Indies, Cave Hill Campus. Methods: The study is a cross-sectional study with a self-administered on-line questionnaire which included a three-day semi-quantitative food frequency questionnaire. Variables measured were sodium and potassium intake, body mass index (BMI) and perceptions of health and dietary intake...
March 8, 2016: West Indian Medical Journal
M Lyman, J O Mills, A R Shipman
BACKGROUND: Malignant melanoma presents a significant health burden in the UK in terms of mortality and financial cost. This aggressive and often fatal disease is under-diagnosed among patients with darker skin tones (type 5 and 6) such as Afro-Caribbean patients. A lack of both patient and practitioner awareness leads to a later diagnosis in patients with black compared to white skin. There is currently a paucity of literature looking at the diagnosis rates of melanoma between patients of different ethnicities in the UK and the reasons behind these differences...
August 31, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
G Yerlikaya, R Akolekar, K McPherson, A Syngelaki, K H Nicolaides
OBJECTIVES: To develop a model for prediction of stillbirth based on maternal characteristics and components of medical history and to evaluate the performance of screening with this model for all stillbirths and those due to impaired placentation and to unexplained causes. METHODS: This was a prospective screening study of 113 415 singleton pregnancies at 11 + 0 to 13 + 6 weeks' gestation and at 19 + 0 to 24 + 6 weeks. The study population included 113 019 live births and 396 (0...
August 26, 2016: Ultrasound in Obstetrics & Gynecology
Joyce L Browne, Kerstin Klipstein-Grobusch, Maria P H Koster, Dhivya Ramamoorthy, Edward Antwi, Idder Belmouden, Arie Franx, Diederick E Grobbee, Peter C J I Schielen
BACKGROUND: Baseline distributions of pregnancy disorders' biomarkers PlGF and PAPP-A levels are primarily based on Western European populations of Caucasian ethnicity. Differences in PAPP-A and PlGF concentrations by ethnicity have been observed, with increased levels in Afro-Caribbean, East Asian, and South Asian women. Baseline concentrations of sub-Saharan African women have not been evaluated. OBJECTIVES: To investigate PlGF and PAPP-A in a sub-Saharan African population and assess the performance of existing reference values of PAPP-A and PlGF...
2016: PloS One
I J Rodney, C Kindred, K Angra, O N Qutub, A R Villanueva, R M Halder
IMPORTANCE: Hypopigmented mycosis fungoides is a rare variant of mycosis fungoides with limited published clinicohistopathologic data available. OBJECTIVE: To characterize our patient group, to provide additional information and insight into this malignancy. DESIGN: A 16-year retrospective medical records review (from 1992 to 2009) was conducted of patients with a diagnosis of hypopigmented mycosis fungoides. SETTING: All patients were seen in the department of dermatology at Howard University Hospital, an outpatient clinic in an urban academic institution...
August 12, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Shamir O Cawich, Michael T Gardner, Ramnanand Shetty, Neil W Pearce, Vijay Naraynsingh
INTRODUCTION: There have been no previous reports on the anatomic variations that exist on inferior surface of the liver in Caribbean populations. This information is important to optimize radiology and hepatobiliary surgical services in the region. METHODS: Two investigators independently observed 69 cadaveric dissections over five years and described the variations in surface anatomy. RESULTS: In this population 88% of cadaveric livers had conventional hepatic surface anatomy...
June 2016: International Journal of Biomedical Science: IJBS
N J Crabtree, N J Shaw, N J Bishop, J E Adams, M Z Mughal, P Arundel, M S Fewtrell, S F Ahmed, L A Treadgold, W Högler, N A Bebbington, K A Ward
The increasing use of dual energy X-ray absorptiometry (DXA) in children has led to the need for robust reference data for interpretation of scans in daily clinical practice. Such data need to be representative of the population being studied and be 'future-proofed' to software and hardware upgrades. The aim was to combine all available paediatric DXA reference data from seven UK centres to create reference curves adjusted for age, sex, ethnicity and body size to enable clinical application, using in-vivo cross calibration and making data back- and forward- compatible...
August 4, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Maria Angela Gosein, Dylan Narinesingh, Cemonne Ann-Alicia Celeste Nixon, Sanjeeva Reddy Goli, Paramanand Maharaj, Alexander Sinanan
BACKGROUND: Cowden syndrome is an autosomal dominant disorder with a predisposition to multiple benign and malignant tumors. In our patient, in addition to breast and endometrial malignancies as well as facial trichilemmomas, she was noted to have multiple meningiomas, pancreatic lipomas and lung cysts. These latter lesions have been noted in previous Cowden syndrome case reports, but are not included in the diagnostic criteria at this time. To our knowledge, this is the first case of multiple meningiomas in this syndrome...
2016: BMC Research Notes
A Zengin, S R Pye, M J Cook, J E Adams, F C W Wu, T W O'Neill, K A Ward
Relatively little is known about the bone health of ethnic groups within the UK and data are largely restricted to women. The aim of this study was to investigate ethnic differences in areal bone mineral density (aBMD), volumetric bone mineral density (vBMD), bone geometry and strength in UK men. White European, Black Afro-Caribbean and South Asian men aged over 40years were recruited from Greater Manchester, UK. aBMD at the spine, hip, femoral neck and whole body were measured by DXA. Bone geometry, strength and vBMD were measured at the radius and tibia using pQCT at the metaphysis (4%) and diaphysis (50% radius; 38% tibia) sites...
October 2016: Bone
Etienne Ghrenassia, Arsene Mekinian, Catherine Chapelon-Albric, Pierre Levy, Jacques Cosnes, Pascal Sève, Guillaume Lefèvre, Robin Dhôte, David Launay, Virginie Prendki, Sandrine Morell-Dubois, Danielle Sadoun, Anas Mehdaoui, Michael Soussan, Anne Bourrier, Laure Ricard, Robert Benamouzig, Dominique Valeyre, Olivier Fain
Digestive tract sarcoidosis (DTS) is rare and case-series are lacking. In this retrospective case-control study, we aimed to compare the characteristics, outcome, and treatment of patients with DTS, nondigestive tract sarcoidosis (NDTS), and Crohn disease.We included cases of confirmed sarcoidosis, symptomatic digestive tract involvement, and noncaseating granuloma in any digestive tract. Each case was compared with 2 controls with sarcoidoisis without digestive tract involvement and 4 with Crohn disease.We compared 25 cases of DTS to 50 controls with NDTS and 100 controls with Crohn disease...
July 2016: Medicine (Baltimore)
Ethan H Mereish, Hammad S N'cho, Carlton E Green, Maryam M Jernigan, Janet E Helms
Discrimination is related to depression and poor self-esteem among Black men. Poorer self-esteem is also associated with depression. However, there is limited research identifying how self-esteem may mediate the associations between discrimination and depressive symptoms for disparate ethnic groups of Black men. The purpose of this study was to examine ethnic groups as a moderator of the mediating effects of self-esteem on the relationship between discrimination and depressive symptoms among a nationally representative sample of African American (n = 1201) and Afro-Caribbean American men (n = 545) in the National Survey of American Life...
July 2016: Behavioral Medicine
George Tackley, Fanny O'Brien, João Rocha, Mark Woodhall, Patrick Waters, Saleel Chandratre, Christopher Halfpenny, Cheryl Hemingway, Evangeline Wassmer, Warren Wasiewski, Maria Isabel Leite, Jacqueline Palace
OBJECTIVE: Neuromyelitis optica (NMO) is a rare antibody-mediated CNS disease characterised by disabling relapses leading to high morbidity and mortality. Understanding relapse activity and severity is important for treatment decisions and clinical trial design. We assessed (1) whether clinical and demographic factors associate with different relapse rates and (2) the relative impact of immunosuppressive treatments on relapse rates and on attack-related residual disability. METHODS: Clinical, demographic and treatment data were prospectively collected from 79 consecutive aquaporin 4 antibody positive patients seen in the nationally commissioned Oxford NMO service...
May 2016: Multiple Sclerosis and related Disorders
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