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https://www.readbyqxmd.com/read/27921992/the-hubble-trial-haemorrhoidal-artery-ligation-hal-versus-rubber-band-ligation-rbl-for-symptomatic-second-and-third-degree-haemorrhoids-a-multicentre-randomised-controlled-trial-and-health-economic-evaluation
#1
Steven Brown, Jim Tiernan, Katie Biggs, Daniel Hind, Neil Shephard, Mike Bradburn, Allan Wailoo, Abualbishr Alshreef, Lizzie Swaby, Angus Watson, Simon Radley, Oliver Jones, Paul Skaife, Anil Agarwal, Pasquale Giordano, Marc Lamah, Mark Cartmell, Justin Davies, Omar Faiz, Karen Nugent, Andrew Clarke, Angus MacDonald, Phillip Conaghan, Paul Ziprin, Rohit Makhija
BACKGROUND: Optimal surgical intervention for low-grade haemorrhoids is unknown. Rubber band ligation (RBL) is probably the most common intervention. Haemorrhoidal artery ligation (HAL) is a novel alternative that may be more efficacious. OBJECTIVE: The comparison of HAL with RBL for the treatment of grade II/III haemorrhoids. DESIGN: A multicentre, parallel-group randomised controlled trial. PERSPECTIVE: UK NHS and Personal Social Services...
November 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27918334/challenges-of-anesthesia-in-low-and-middle-income-countries-a-cross-sectional-survey-of-access-to-safe-obstetric-anesthesia-in-east-africa
#2
Isabella Epiu, Jossy Verel Bahe Tindimwebwa, Cephas Mijumbi, Thomas M Chokwe, Edwin Lugazia, Francois Ndarugirire, Theogene Twagirumugabe, Gerald Dubowitz
BACKGROUND: The United Nations 2015 Millennium Development Goals targeted a 75% reduction in maternal mortality. However, in spite of this goal, the number of maternal deaths per 100,000 live births remains unacceptably high across Sub-Saharan Africa. Because many of these deaths could likely be averted with access to safe surgery, including cesarean delivery, we set out to assess the capacity to provide safe anesthetic care for mothers in the main referral hospitals in East Africa. METHODS: A cross-sectional survey was conducted at 5 main referral hospitals in East Africa: Uganda, Kenya, Tanzania, Rwanda, and Burundi...
December 1, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27914088/murine-mycobacterium-marinum-infection-as-a-model-for-tuberculosis
#3
Julia Lienard, Fredric Carlsson
Mycobacteria are a major human health problem globally. Regarding tuberculosis the situation is worsened by the poor efficacy of current vaccine regimens and by emergence of drug-resistant strains (Manjelievskaia J et al, Trans R Soc Trop Med Hyg 110: 110, 2016; Pereira et al., Lancet Infect Dis 12:300-306, 2012; http://www.who.int/tb/publications/global_report/en/) undermining both disease-prevention and available treatments. Thus, increased basic understanding of mycobacterial-and particularly Mycobacterium tuberculosis-virulence strategies and pathogenesis is of great importance...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27905017/an-evaluation-of-preparedness-delivery-and-impact-of-surgical-and-anesthesia-care-in-madagascar-a-framework-for-a-national-surgical-plan
#4
Emily Bruno, Michelle C White, Linden S Baxter, Vaonandianina Agnès Ravelojaona, Hasiniaina Narindria Rakotoarison, Hery Harimanitra Andriamanjato, Kristin L Close, Alison Herbert, Nakul Raykar, Saurabh Saluja, Mark G Shrime
BACKGROUND: The Lancet Commission on Global Surgery (LCoGS) described the lack of access to safe, affordable, timely surgical, and anesthesia care. It proposed a series of 6 indicators to measure surgery, accompanied by time-bound targets and a template for national surgical planning. To date, no sub-Saharan African country has completed and published a nationwide evaluation of its surgical system within this framework. METHOD: Mercy Ships, in partnership with Harvard Medical School and the Madagascar Ministry of Health, collected data on the 6 indicators from 22 referral hospitals in 16 out of 22 regions of Madagascar...
November 30, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27899610/malacards-an-amalgamated-human-disease-compendium-with-diverse-clinical-and-genetic-annotation-and-structured-search
#5
Noa Rappaport, Michal Twik, Inbar Plaschkes, Ron Nudel, Tsippi Iny Stein, Jacob Levitt, Moran Gershoni, C Paul Morrey, Marilyn Safran, Doron Lancet
The MalaCards human disease database (http://www.malacards.org/) is an integrated compendium of annotated diseases mined from 68 data sources. MalaCards has a web card for each of ∼20 000 disease entries, in six global categories. It portrays a broad array of annotation topics in 15 sections, including Summaries, Symptoms, Anatomical Context, Drugs, Genetic Tests, Variations and Publications. The Aliases and Classifications section reflects an algorithm for disease name integration across often-conflicting sources, providing effective annotation consolidation...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27894649/the-unacceptable-reality-of-care-for-people-living-with-dementia
#6
EDITORIAL
The Lancet
No abstract text is available yet for this article.
November 26, 2016: Lancet
https://www.readbyqxmd.com/read/27894647/addressing-addiction-in-the-usa
#7
EDITORIAL
The Lancet
No abstract text is available yet for this article.
November 26, 2016: Lancet
https://www.readbyqxmd.com/read/27890495/critical-care-guidelines-more-science-less-art
#8
EDITORIAL
The Lancet Respiratory Medicine
No abstract text is available yet for this article.
December 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27890071/updates-on-blood-transfusion-guidelines
#9
EDITORIAL
The Lancet Haematology
No abstract text is available yet for this article.
December 2016: Lancet Haematology
https://www.readbyqxmd.com/read/27889001/treatment-choice-and-psychiatry
#10
EDITORIAL
The Lancet Psychiatry
No abstract text is available yet for this article.
December 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27886742/drugs-for-chronic-diseases-getting-the-price-right
#11
EDITORIAL
The Lancet Diabetes Endocrinology
No abstract text is available yet for this article.
December 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27884370/the-allure-of-a-simple-story
#12
EDITORIAL
The Lancet Hiv
No abstract text is available yet for this article.
December 2016: Lancet HIV
https://www.readbyqxmd.com/read/27871733/measles-vaccination-global-progress-local-challenges
#13
EDITORIAL
The Lancet
No abstract text is available yet for this article.
November 19, 2016: Lancet
https://www.readbyqxmd.com/read/27871732/crisis-point-for-radiology-and-oncology-workforces
#14
EDITORIAL
The Lancet
No abstract text is available yet for this article.
November 19, 2016: Lancet
https://www.readbyqxmd.com/read/27871731/president-trump
#15
EDITORIAL
The Lancet
No abstract text is available yet for this article.
November 19, 2016: Lancet
https://www.readbyqxmd.com/read/27871245/methicillin-resistant-staphylococcus-aureus-in-ethiopia-a-meta-analysis
#16
Setegn Eshetie, Fentahun Tarekegn, Feleke Moges, Anteneh Amsalu, Wubet Birhan, Kahsay Huruy
BACKGROUND: The burden of methicillin resistant Staphylococcus aureus is a major public health concern worldwide; however the overall epidemiology of multidrug resistant strains is neither coordinated nor harmonized, particularly in developing countries including Ethiopia. Therefore, the aim of this meta-analysis was to assess the burden of methicillin resistant Staphylococcos aureus and its antibiotic resistance pattern in Ethiopia at large. METHODS: PubMed, Google Scholar, and lancet databases were searched and a total of 20 studies have been selected for meta-analysis...
November 21, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27858205/statistical-inference-in-abstracts-of-major-medical-and-epidemiology-journals-1975-2014-a-systematic-review
#17
REVIEW
Andreas Stang, Markus Deckert, Charles Poole, Kenneth J Rothman
Since its introduction in the twentieth century, null hypothesis significance testing (NHST), a hybrid of significance testing (ST) advocated by Fisher and null hypothesis testing (NHT) developed by Neyman and Pearson, has become widely adopted but has also been a source of debate. The principal alternative to such testing is estimation with point estimates and confidence intervals (CI). Our aim was to estimate time trends in NHST, ST, NHT and CI reporting in abstracts of major medical and epidemiological journals...
November 17, 2016: European Journal of Epidemiology
https://www.readbyqxmd.com/read/27856085/the-lancet-countdown-tracking-progress-on-health-and-climate-change
#18
REVIEW
Nick Watts, W Neil Adger, Sonja Ayeb-Karlsson, Yuqi Bai, Peter Byass, Diarmid Campbell-Lendrum, Tim Colbourn, Peter Cox, Michael Davies, Michael Depledge, Anneliese Depoux, Paula Dominguez-Salas, Paul Drummond, Paul Ekins, Antoine Flahault, Delia Grace, Hilary Graham, Andy Haines, Ian Hamilton, Anne Johnson, Ilan Kelman, Sari Kovats, Lu Liang, Melissa Lott, Robert Lowe, Yong Luo, Georgina Mace, Mark Maslin, Karyn Morrissey, Kris Murray, Tara Neville, Maria Nilsson, Tadj Oreszczyn, Christine Parthemore, David Pencheon, Elizabeth Robinson, Stefanie Schütte, Joy Shumake-Guillemot, Paolo Vineis, Paul Wilkinson, Nicola Wheeler, Bing Xu, Jun Yang, Yongyuan Yin, Chaoqing Yu, Peng Gong, Hugh Montgomery, Anthony Costello
The Lancet Countdown: tracking progress on health and climate change is an international, multidisciplinary research collaboration between academic institutions and practitioners across the world. It follows on from the work of the 2015 Lancet Commission, which concluded that the response to climate change could be "the greatest global health opportunity of the 21st century". The Lancet Countdown aims to track the health impacts of climate hazards; health resilience and adaptation; health co-benefits of climate change mitigation; economics and finance; and political and broader engagement...
November 11, 2016: Lancet
https://www.readbyqxmd.com/read/27855855/the-un-in-haiti-an-adulterated-vision-of-accountability
#19
EDITORIAL
The Lancet Global Health
No abstract text is available yet for this article.
December 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27855102/non-inferiority-trials-are-they-inferior-a-systematic-review-of-reporting-in-major-medical-journals
#20
Sunita Rehal, Tim P Morris, Katherine Fielding, James R Carpenter, Patrick P J Phillips
OBJECTIVE: To assess the adequacy of reporting of non-inferiority trials alongside the consistency and utility of current recommended analyses and guidelines. DESIGN: Review of randomised clinical trials that used a non-inferiority design published between January 2010 and May 2015 in medical journals that had an impact factor >10 (JAMA Internal Medicine, Archives Internal Medicine, PLOS Medicine, Annals of Internal Medicine, BMJ, JAMA, Lancet and New England Journal of Medicine)...
October 7, 2016: BMJ Open
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