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https://www.readbyqxmd.com/read/28075182/dispersing-the-mists-an-experimental-history-of-medicine-study-into-the-quality-of-volatile-inhalations
#1
Barry Murnane, Cathal T Gallagher, Noel Snell, Mark Sanders, Ramin Moshksar, Darragh Murnane
BACKGROUND: Dr. Nelson's Improved Inhaler was first marketed with an advertisement in The Lancet in 1865. Revolutionary at the time for its ease of use and patient-friendliness, the inhaler is still in use for self-treatment by many all over the world. On the occasion of its 150th anniversary, this study reports an experimental historical medicine approach to identify evidence for the quality of vapor inhalers. METHODS: Through accessing reviews of the device's use by the contemporary medical establishment, it was established that Dr...
January 11, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28066825/a-blinded-randomised-placebo-controlled-trial-investigating-the-efficacy-of-morphine-analgesia-for-procedural-pain-in-infants-trial-protocol
#2
Rebeccah Slater, Caroline Hartley, Fiona Moultrie, Eleri Adams, Ed Juszczak, Richard Rogers, Jane E Norman, Chetan Patel, Kayleigh Stanbury, Amy Hoskin, Gabrielle Green
Infant pain has both immediate and long-term negative consequences, yet in clinical practice it is often undertreated. To date, few pain-relieving drugs have been tested in infants. Morphine is a potent analgesic that provides effective pain relief in adults, but there is inconclusive evidence for its effectiveness in infants. The purpose of this study is to establish whether oral morphine provides effective analgesia for procedural pain in infants. A blinded, placebo-controlled, parallel-group randomized, phase II, clinical trial will be undertaken to determine whether morphine sulphate administered orally prior to clinically-required retinopathy of prematurity (ROP) screening and heel lancing provides effective analgesia...
November 15, 2016: Wellcome Open Res
https://www.readbyqxmd.com/read/28064463/global-research-trends-in-lithium-toxicity-from-1913-to-2015-a-bibliometric-analysis
#3
Sa'ed H Zyoud, W Stephen Waring, Waleed M Sweileh, Samah W Al-Jabi
Lithium salts have been used to treat psychiatric disorders since the 1940s and are currently used in prophylaxis and treatment of depression and bipolar disorder. Therefore, we conducted this study to assess lithium toxicity-related publications using bibliometric approaches from a health point of view to assess global research trends in the lithium toxicity field to offer guidance to future research in this field. The data were retrieved from the online version of Scopus database on 6 August 2016. All records with the term "lithium" in the title were retrieved, and those related to lithium toxicity were evaluated...
January 8, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28060886/point-of-care-p24-infant-testing-for-hiv-may-increase-patient-identification-despite-low-sensitivity
#4
Bindiya Meggi, Timothy Bollinger, Nédio Mabunda, Adolfo Vubil, Ocean Tobaiwa, Jorge I Quevedo, Osvaldo Loquiha, Lara Vojnov, Trevor F Peter, Ilesh V Jani
The long delay in returning test results during early infant diagnosis of HIV (EID) often causes loss-to-follow-up prior to antiretroviral treatment (ART) initiation in resource-limited settings. A point-of-care (POC) test may help overcome these challenges. We evaluated the performance of the LYNX p24 Antigen POC test in Mozambique. 879 HIV-exposed infants under 18 months of age were enrolled consecutively at three primary healthcare clinics (PHC). Lancet heel-drawn blood was tested on-site by nurses using a prototype POC test for HIV Gag p24 antigen detection...
2017: PloS One
https://www.readbyqxmd.com/read/28050393/metronomic-chemotherapy-seems-prowess-to-battle-against-cancer-in-current-scenario
#5
Prema Muthusamy, Krishnan Vengadaragava Chary, G K Nalini
INTRODUCTION: Metronomic chemotherapy is an emerging method of chemotherapy. Metronomic 'lowdose' chemotherapy regimen induces tumour dormancy and reduces cancer resistance against anticancer drugs. It tends to improve overall success rate of cancer chemotherapy than conventional cyclical regimen. AIM: The aim of this systemic review was to provide comprehensive data of metronomic chemotherapy trials, regimens used and it's outcome in cancer therapeutics. MATERIALS AND METHODS: Fifty chemotherapy trial data were searched sequentially from web...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28049567/cannabis-high-time-for-evidence-based-policies
#6
EDITORIAL
The Lancet Oncology
No abstract text is available yet for this article.
January 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28048284/su-f-p-08-medical-physics-perspective-on-radiation-therapy-quality-and-safety-considerations-in-low-income-settings
#7
J Van Dyk, A Meghzifene
PURPOSE: The last few years have seen a significant growth of interest in the global radiation therapy crisis. Various organizations are quantifying the need and providing aid in support of addressing the shortfall existing in many low-to-middle income countries (LMICs). The Lancet Oncology Commission report (Lancet Oncol. Sep;16(10):1153-86, 2015) projects a need of 22,000 new medical physicists in LMICs by 2035 if there is to be equal access globally. With the tremendous demand for new facilities, equipment and personnel, it is very important to recognize quality and safety considerations and to address them directly...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28041581/clinical-trial-reporting-an-evolving-process
#8
EDITORIAL
The Lancet Haematology
No abstract text is available yet for this article.
January 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28040092/global-access-to-radiotherapy-in-low-and-middle-income-countries
#9
M Abdel-Wahab, E Fidarova, A Polo
Over the last 60 years, the International Atomic Energy Agency (IAEA) has been working to introduce, expand and improve radiotherapy services, working with partners such as the World Health Organization (WHO) to improve cancer diagnosis, treatment, care and control through collective action in low- and middle-income countries (LMICs). The Lancet Oncology Commission on radiotherapy published a report that defined five calls for action to expand global access to radiotherapy, drawing on the previous work of the Global Taskforce on Radiotherapy for Cancer Control...
February 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28032479/the-role-of-nutrition-in-integrated-early-child-development-in-the-21st-century-contribution-from-the-maternal-and-child-nutrition-journal
#10
EDITORIAL
Rafael Pérez-Escamilla, Victoria Hall Moran
Even though it is widely recognized that early childhood development (ECD) is one of the most important predictors of future social capital and national productivity, the recently published ECD Lancet Series reports that about 250 million children under 5 years are at risk of not reaching their developmental potential, mainly as a result of poverty and social injustice. So why is this and what will it take to reverse this situation? The purpose of this special issue is to highlight important contributions from previously published articles in Maternal & Child Nutrition to the field of nutrition and ECD...
January 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28031041/building-health-research-systems-who-is-generating-global-perspectives-and-who-s-celebrating-national-successes
#11
EDITORIAL
Stephen R Hanney, Miguel A González-Block
In 2016, England's National Institute for Health Research (NIHR) celebrated its tenth anniversary as an innovative national health research system with a focus on meeting patients' needs. This provides a good opportunity to reflect on how the creation of the NIHR has greatly enhanced important work, started in 1991, to develop a health research system in England that is embedded in the National Health Service.In 2004, WHO identified a range of functions that a national health research system should undertake to improve the health of populations...
December 28, 2016: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28030373/what-are-the-most-promising-new-agents-in-acute-myeloid-leukemia
#12
David A Sallman, Jeffrey E Lancet
PURPOSE OF REVIEW: Although the treatment paradigm for acute myeloid leukemia (AML) had been largely unchanged for many years, in-depth molecular characterization has revolutionized our understanding of mutations that drive the disease, subsequently serving to guide current clinical investigation. Furthermore, recent advances in the field have highlighted the importance of optimizing known efficacious agents by improving drug delivery or bypassing resistance mechanisms. The current status of novel agents which are shaping the clinical management of AML patients are summarized in this review...
December 26, 2016: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28027060/methodological-quality-of-surgical-mortality-studies-using-large-hospital-databases-a-systematic-review
#13
Cécile Payet, Jean-Christophe Lifante, Matthew J Carty, Muriel Rabilloud, Antoine Duclos
OBJECTIVE: To review the methodology employed in surgical mortality studies to control for potential confounders. SUMMARY BACKGROUND DATA: Nationwide hospital data are increasingly used to investigate surgical outcomes. However, poor data granularity and coding inaccuracies may lead to flawed findings. METHODS: We conducted a systematic review in accordance with the PRISMA statement in 6 major journals (NEJM, Lancet, BMJ, JAMA, Medical Care, Annals of Surgery) using PubMed from its inception until December 31, 2014...
December 23, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/28017400/the-lancet-planetary-health-a-new-journal-for-a-new-discipline-a-call-for-papers
#14
Raffaella Bosurgi, Richard Horton
No abstract text is available yet for this article.
December 22, 2016: Lancet
https://www.readbyqxmd.com/read/28012780/achieving-a-grand-convergence-in-global-health-by-2035
#15
Adel Mahmoud
Historical evidence demonstrates the validity of the concept "Grand Convergence". The Lancet commission identified the major challenges facing low and lower middle income countries including the unfinished agenda, non-communicable diseases and injuries and an approach to funding and achieving these objectives along with progress towards universal health care. The role of vaccines is summarized as a major approach to accomplish a Grand Convergence in a generation.
December 22, 2016: Vaccine
https://www.readbyqxmd.com/read/28012466/like-a-prayer
#16
EDITORIAL
The Lancet Psychiatry
No abstract text is available yet for this article.
January 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28007342/will-president-trump-protect-his-party-s-pepfar-legacy
#17
EDITORIAL
The Lancet Hiv
No abstract text is available yet for this article.
January 2017: Lancet HIV
https://www.readbyqxmd.com/read/28007341/better-late-than-never-prep-in-england
#18
EDITORIAL
The Lancet Hiv
No abstract text is available yet for this article.
January 2017: Lancet HIV
https://www.readbyqxmd.com/read/28007026/gemcitabine-improves-survival-in-patients-with-recurrent-or-metastatic-nasopharyngeal-carcinoma
#19
Shaodong Hong, Li Zhang
For decades, the selection of chemotherapeutic regimens for the treatment of recurrent or metastatic nasopharyngeal carcinoma has been mainly empirical. To our knowledge, there is no phase 3 trial that has been conducted to determine the optimal treatment for these patients before our publication. Recently, we published an article in The Lancet entitled "Gemcitabine plus cisplatin versus fluorouracil plus cisplatin in recurrent or metastatic nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial...
December 22, 2016: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28006850/bone-marrow-cellularity-at-day-14-is-the-most-important-predictive-factor-for-response-in-patients-with-aml-who-require-double-induction-chemotherapy-analysis-from-a-large-single-institution-experience
#20
Patrick T Griffin, Rami S Komrokji, Kendra Sweet, Najla H Al Ali, Eric Padron, Timothy E Kubal, Alan F List, Jeffrey E Lancet
In patients with acute myeloid leukemia (AML), the presence of residual disease at day 14 after primary induction therapy warrants consideration of a second induction cycle. However, data to guide retreatment decisions in such patients are presently limited. Here, we retrospectively reviewed data from 176 patients with AML treated at our institution with a second induction chemotherapy regimen because of day 14 residual disease. Clinical variables and nadir bone marrow features were assessed for correlations with complete remission (CR) and overall survival (OS)...
December 22, 2016: American Journal of Hematology
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