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https://www.readbyqxmd.com/read/29050204/irreversible-growth-plate-fusions-in-children-with-medulloblastoma-treated-with-a-targeted-hedgehog-pathway-inhibitor
#1
Giles W Robinson, Sue C Kaste, Wassim Chemaitilly, Daniel C Bowers, Stephen Laughton, Amy Smith, Nicholas G Gottardo, Sonia Partap, Anne Bendel, Karen D Wright, Brent A Orr, William C Warner, Arzu Onar-Thomas, Amar Gajjar
The permanent defects in bone growth observed in preclinical studies of hedgehog (Hh) pathway inhibitors were not substantiated in early phase clinical studies of vismodegib in children. Consequently, vismodegib advanced into pediatric trials for malignancies suspected of being driven by aberrant activation of the Hh pathway. In one multicenter phase II trial, vismodegib was added to the therapy regimen for newly diagnosed Hh pathway activated medulloblastoma. Herein, we report on 3 children (2 on trial and one off trial) treated with vismodegib who developed widespread growth plate fusions that persist long after cessation of therapy...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049131/comparison-of-surgical-outcomes-narcotics-utilization-and-costs-after-an-anterior-cervical-discectomy-and-fusion-stand-alone-cage-versus-anterior-plating
#2
Ehsan Tabaraee, Junyoung Ahn, Daniel D Bohl, Michael J Collins, Dustin H Massel, Khaled Aboushaala, Kern Singh
STUDY DESIGN: Retrospective cohort analysis of a prospectively maintained registry. OBJECTIVE: To compare the surgical outcomes, narcotic utilization, and costs between a stand-alone (SA) cage and anterior plating (AP) with an interbody device for 1-level anterior cervical discectomy and fusion (ACDF). BACKGROUND DATA: ACDF with a SA cage has gained popularity as a potential alternative to anterior cervical plating. Few studies have compared the surgical outcomes, narcotic utilization, and costs of ACDF utilizing a SA cage versus AP with an interbody device...
November 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29016435/comparison-of-outcomes-for-anterior-cervical-discectomy-and-fusion-with-and-without-anterior-plate-fixation-a-systematic-review-and-meta-analysis
#3
Jeremie D Oliver, Sandy Goncalves, Panagiotis Kerezoudis, Mohammed Ali Alvi, Brett A Freedman, Ahmad Nassr, Mohamad Bydon
STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVE: To compare postoperative surgical, radiographic and patient-reported outcomes following ACDF with and without plate fixation. SUMMARY OF BACKGROUND DATA: Anterior cervical discectomy and fusion (ACDF) has evolved significantly over the years, including the placement of an anterior plate construct. Although promoting bony osseo-integration at the fusion site, there are a number of plate-related complications that can arise...
October 9, 2017: Spine
https://www.readbyqxmd.com/read/28989848/biomechanical-stability-of-a-stand-alone-interbody-spacer-in-two-level-and-hybrid-cervical-fusion-constructs
#4
Daniel G Kang, Scott C Wagner, Robert W Tracey, John P Cody, Rachel E Gaume, Ronald A Lehman
STUDY DESIGN: In vitro human cadaveric biomechanical analysis. OBJECTIVE: To evaluate the segmental stability of a stand-alone spacer (SAS) device compared with the traditional anterior cervical plate (ACP) construct in the setting of a 2-level cervical fusion construct or as a hybrid construct adjacent to a previous 1-level ACP construct. METHODS: Twelve human cadaveric cervical spines (C2-T1) were nondestructively tested with a custom 6-degree-of-freedom spine simulator under axial rotation (AR), flexion-extension (FE), and lateral bending (LB) at 1...
October 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28987856/comparison-of-chronic-dysphagia-in-standalone-versus-conventional-plate-and-cage-fusion
#5
Christian Fisahn, Cameron Schmidt, Tarush Rustagi, Marc Moisi, Joe Iwanaga, Daniel C Norvell, R Shane Tubbs, Thomas A Schildhauer, Jens R Chapman
INTRODUCTION: Standalone cages have gained popularity due to their ease of implantation, reduced operating time, and lower profile compared to traditional plate and cage systems. The aim of this study was to compare the risk of chronic dysphagia among those who undergo ACDF with traditional plating techniques versus standalone systems. MATERIAL AND METHODS: Between 2014 and 2015, we identified 377 consecutive patients meeting study criteria (standalone, n= 211; plate-cage, n= 166)...
October 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28986227/anterior-cervical-discectomy-with-instrumented-allograft-fusion-lordosis-restoration-and-comparison-of-functional-outcomes-among-patients-of-different-age-groups
#6
Dario Muzevic, Bruno Splavski, Frederick A Boop, Kenan I Arnautovic
OBJECTIVE: To investigate clinical parameters of anterior cervical discectomy and fusion (ACDF) treatment and outcomes using osseous allograft in different age groups, study postoperative results of restoring of lordosis, and evaluate the utility of bone allografts for ACDF, including graft subsidence. METHODS: We reviewed data from 154 patients having clinical symptoms and radiological signs of disc herniation and/or cervical spondylosis. Decompression was achieved through discectomy, osteophyte ablation, endplate drilling, and foraminotomy...
October 3, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28974337/iodoacetyl-functionalized-pullulan-a-supplemental-enhancer-for-single-domain-antibody-polyclonal-antibody-sandwich-enzyme-linked-immunosorbent-assay-for-detection-of-survivin
#7
Takahiko Matsushita, Hidenao Arai, Tetsuo Koyama, Ken Hatano, Naoto Nemoto, Koji Matsuoka
Survivin, an inhibitor of the apoptosis protein family, is a potent tumor marker for diagnosis and prognosis. The enzyme-linked immunosorbent assay (ELISA) is one of the methods that has been used for detection of survivin. However, ELISA has several disadvantages caused by the use of conventional antibodies, and we have therefore been trying to develop a novel ELISA system using camelid single-domain antibodies (VHHs) as advantageous replacements. Here we report a supplemental approach to improve the VHH-polyclonal antibody sandwich ELISA for survivin detection...
September 23, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28963160/accuracy-of-ct-navigated-pedicle-screw-positioning-in-the-cervical-and-upper-thoracic-region-with-and-without-prior-anterior-surgery-and-ventral-plating
#8
COMPARATIVE STUDY
A Rienmüller, N Buchmann, J S Kirschke, E L Meyer, J Gempt, J Lehmberg, B Meyer, Y M Ryang
AIMS: We aimed to retrospectively assess the accuracy and safety of CT navigated pedicle screws and to compare accuracy in the cervical and thoracic spine (C2-T8) with (COMB) and without (POST) prior anterior surgery (anterior cervical discectomy or corpectomy and fusion with ventral plating: ACDF/ACCF). PATIENTS AND METHODS: A total of 592 pedicle screws, which were used in 107 consecutively operated patients (210 COMB, 382 POST), were analysed. The accuracy of positioning was determined according to the classification of Gertzbein and Robbins on post-operative CT scans...
October 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28942019/failure-patterns-in-standalone-anterior-cervical-discectomy-and-fusion-implants
#9
Fernando Alonso, Tarush Rustagi, Cameron Schmidt, Daniel C Norvell, R Shane Tubbs, Rod J Oskouian, Jens R Chapman, Christian Fisahn
INTRODUCTION: Anterior cervical discectomy and fusion is commonly performed using an allograft or autograft implant and anterior screw-supported plate. There has been an increase in the use of standalone cage devices due to ease of use and studies suggesting a lower rate of acute post-operative dysphagia. We review our experience with standalone cage devices and identify risk factors, patterns of failure, and revision surgery approaches. MATERIALS AND METHODS: We performed a retrospective case-series of patients treated at a single tertiary care institution between March 2014 and March 2015...
September 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28937463/combined-anterior-posterior-fixation-and-fusion-for-completely-dislocated-hangman-s-fracture-a-retrospective-analysis-of-11-cases
#10
Jianxi Wang, Huajiang Chen, Peng Cao, Wen Yuan, Xiaodong Wu, Gang Liu, Renhu Li, Fazhi Zang, Liangyu Shi, An Wang
STUDY DESIGN: Retrospective clinical study. PURPOSE: To evaluate the effectiveness and feasibility of combined anterior-posterior fixation and fusion for the treatment of completely dislocated hangman's fracture. SUMMARY OF BACKGROUND DATA: A completely dislocated hangman's fracture describes the complete anterior displacement of the C2 vertebral body onto the C3 body. This type of fracture is exceptionally unstable, and for which the management is challenging...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28911616/production-of-a-monoclonal-antibody-against-aflatoxin-m1-and-its-application-for-detection-of-aflatoxin-m1-in-fortified-milk
#11
Umarphorn Chadseesuwan, Apinya Sangdokmai, Umaporn Pimpitak, Songchan Puthong, Tanapat Palaga, Kittinan Komolpis
Aflatoxin M1 (AFM1) is a toxic metabolite of the fungal product aflatoxin found in milk. For food safety concern, maximum residual limits of AFM1 in milk and dairy products have been differently enforced in many countries. A suitable detection method is required to screen a large number of product samples for the AFM1 contamination. In this study, monoclonal antibodies (MAbs) against AFM1 were generated using a conventional somatic cell fusion technique. After screening, five MAbs (AFM1-1, AFM1-3, AFM1-9, AFM1-11, and AFM1-17) were obtained that showed cross-reactivity with aflatoxin B1 (AFB1) and aflatoxin G1 (AFG1) but with no other tested compounds...
October 2016: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28900671/-wrist-arthrodesis-with-a%C3%A2-fixed-angle-low-profile-fusion-plate-without-carpometacarpal-joint-fixation
#12
REVIEW
S Köhler, K Koch, A Arsalan-Werner, I M Mehling, J Seegmüller, H Krimmer, Michael Sauerbier
OBJECTIVE: Total wrist arthrodesis to improve functional use of the hand by reducing pain and increasing grip strength. INDICATIONS: Painful destruction of the radio- and midcarpal joints. CONTRAINDICATIONS: Analgesia and satisfactory hand function after motion-preserving surgical or conservative treatment. Chronic joint infection. SURGICAL TECHNIQUE: Posterior approach to the wrist. Removal of articular surfaces destroyed all the way down to cancellous bone...
September 12, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28888365/functional-reconstitution-of-cell-free-synthesized-purified-kv-channels
#13
Stéphane Renauld, Sandra Cortes, Beate Bersch, Xavier Henry, Michel De Waard, Béatrice Schaack
The study of ion channel activity and the screening of possible inhibitor molecules require reliable methods for production of active channel proteins, their insertion into artificial membranes and for the measurement of their activity. Here we report on cell-free expression of soluble and active Kv1.1 and Kv1.3 channels and their efficient insertion into liposomes. Two complementary methods for the determination of the electrical activity of the proteoliposome-embedded channels were compared using Kv1.1 as a model system: (1) single channel recordings in droplet interface bilayers (DIB) and (2) measurement of the membrane voltage potential generated by a potassium ion diffusion potential using the voltage-sensitive fluorescent dye oxonol VI...
September 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28881654/fusion-between-m2-macrophages-and-cancer-cells-results-in-a-subpopulation-of-radioresistant-cells-with-enhanced-dna-repair-capacity
#14
Annelie Lindström, Kristine Midtbö, Lars-Gunnar Arnesson, Stina Garvin, Ivan Shabo
Cell fusion is a natural biological process in normal development and tissue regeneration. Fusion between cancer cells and macrophages results in hybrids that acquire genetic and phenotypic characteristics from both maternal cells. There is a growing body of in vitro and in vivo data indicating that this process also occurs in solid tumors and may play a significant role in tumor progression. However, investigations of the response of macrophage:cancer cell hybrids to radiotherapy have been lacking. In this study, macrophage:MCF-7 hybrids were generated by spontaneous in vitro cell fusion...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881118/the-effect-of-uncinate-process-resection-on-subsidence-following-anterior-cervical-discectomy-and-fusion
#15
Su Hun Lee, Jun Seok Lee, Soon Ki Sung, Dong Wuk Son, Sang Weon Lee, Geun Sung Song
OBJECTIVE: Subsidence is a frequent complication of anterior cervical discectomy and fusion. Postoperative segmental micro-motion, thought to be a causative factor of subsidence, has been speculated to increase with uncinate process resection area (UPR). To evaluate the effect of UPR on micro-motion, we designed a method to measure UPR area based on pre- and postoperative computed tomography images and analyzed the relationship between UPR and subsidence as a proxy of micro-motion. METHODS: We retrospectively collected clinical and radiological data from January 2011 to June 2016...
September 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28875132/open-wound-management-of-esophagocutaneous-fistula-in-unstable-cervical-spine-after-corpectomy-and-multilevel-laminectomy-a-case-report-and-review-of-the-literature
#16
Hossein Elgafy, Mustafa Khan, Jacob Azurdia, Nicholas Peters
A 67-year-old female patient developed an esophagocutaneous fistula 4 mo after C4 and C5 partial corpectomy. Plain radiograph and computed tomography (CT) scan of cervical spine showed inferior screws pullout with plate migration that caused the esophageal perforation. Management included removal of anterior hardware, revision C4-5 corpectomy, iliac crest strut autograft and halo orthosis immobilization. The fistula was treated using antibiotics and a 10-french gauge rubber tube for daily irrigation and Penrose drain...
August 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28869390/approach-to-interpret-images-produced-by-new-generations-of-multidetector-ct-scanners-in-post-operative-spine
#17
Rania Zeitoun, Manar Hussein
OBJECTIVE: To reach a practical approach to interpret MDCT findings in post-operative spine cases and to change the false belief of CT failure in the setting of instruments secondary to related artefacts. METHODS: We performed observational retrospective analysis of premier, early and late MDCT scans in 68 post-operative spine patients, with emphasis on instruments related complications and osseous fusion status. We used a grading system for assessment of osseous fusion in 35 patients and we further analysed the findings in failure of fusion, grade (D)...
November 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28863660/calibration-of-the-linear-response-range-of-x-ray-imaging-plates-and-their-reader-based-on-image-grayscale-values
#18
Kuan Ren, Tao Xu, Jianhua Zheng, Jianjun Dong, Minxi Wei, Chaoguang Li, Zhurong Cao, Huabing Du, Ji Yan, Guohong Yang, Rongqing Yi, Jiyan Zhang, Tianxuan Huang, Shenye Liu, Feng Wang, Zhiwen Yang, Jin Li, Yaohua Chen, Ke Lan, Guoli Ren, Jie Liu, Yongkun Ding, Shaoen Jiang
X-ray imaging plates are one of the most important X-ray imaging detectors and are widely used in inertial-confinement fusion experiments. However, their linear response range, which is the foundation of their quantitative data analysis, has not been sufficiently deeply investigated. In this work, we develop an X-ray fluorescer calibration system and carefully explore the linear response range of X-ray imaging plates. For the first time, nearly the entire grayscale range of the X-ray imaging plate linear response-7819-64 879 in the range of 0-65 535-has been observed...
August 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28857984/levator-aponeurosis-and-muller-muscle-plication-reinforced-with-levator-sheath-advancement-for-blepharoptosis-correction
#19
Jin Suk Byun, Kun Hwang, Sang Yun Lee, Hak Tae Kim, Kenneth Kim
The authors innovated the levator aponeurosis and Muller muscle plication reinforced with levator sheath advancement (AMPSA) for blepharoptosis correction. The orbital septum was opened 1 mm above its fusion with the levator aponeurosis. The preaponeurotic fat was retracted and the thickened part of the levator sheath was identified. Two plication sutures were made: medial suture at the medial border of the pupil and lateral between the lateral border of the pupil and the lateral limbus. A needle with 6-0 nylon thread first bit the tarsal plate approximately 1 mm below its upper border, then bit the levator aponeurosis and the Muller muscle together at 3 to 6 mm above the upper border of the tarsal plate...
October 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28851705/distinct-functions-for-netrin-1-in-chicken-and-murine-semicircular-canal-morphogenesis
#20
Allison M Nishitani, Sho Ohta, Andrea R Yung, Tony Del Rio, Michael I Gordon, Victoria E Abraira, Evelyn C Avilés, Gary C Schoenwolf, Donna M Fekete, Lisa V Goodrich
The vestibular system of the inner ear detects head position using three orthogonally oriented semicircular canals; even slight changes in their shape and orientation can cause debilitating behavioral defects. During development, the canals are sculpted from pouches that protrude from the otic vesicle, the embryonic anlage of the inner ear. In the center of each pouch, a fusion plate forms where cells lose their epithelial morphology and the basement membrane breaks down. Cells in the fusing epithelia intercalate and are removed, creating a canal...
September 15, 2017: Development
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