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https://www.readbyqxmd.com/read/28304237/cervical-disc-arthroplasty-with-the-prestige-lp-disc-versus-anterior-cervical-discectomy-and-fusion-at-2-levels-results-of-a-prospective-multicenter-randomized-controlled-clinical-trial-at-24-months
#1
Matthew F Gornet, Todd H Lanman, J Kenneth Burkus, Scott D Hodges, Jeffrey R McConnell, Randall F Dryer, Anne G Copay, Hui Nian, Frank E Harrell
OBJECTIVE The authors compared the efficacy and safety of arthroplasty using the Prestige LP cervical disc with those of anterior cervical discectomy and fusion (ACDF) for the treatment of degenerative disc disease (DDD) at 2 adjacent levels. METHODS Patients from 30 investigational sites were randomized to 1 of 2 groups: investigational patients (209) underwent arthroplasty using a Prestige LP artificial disc, and control patients (188) underwent ACDF with a cortical ring allograft and anterior cervical plate...
March 17, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28283840/locking-stand-alone-cages-versus-anterior-plate-constructs-in-single-level-fusion-for-degenerative-cervical-disease-a-systematic-review-and-meta-analysis
#2
REVIEW
Mithun Nambiar, Kevin Phan, John Edward Cunningham, Yi Yang, Peter Lawrence Turner, Ralph Mobbs
PURPOSE: To conduct a meta-analysis to compare the clinical and radiological outcomes in single-level anterior cervical discectomy and fusion (ACDF) surgery for degenerative cervical disease performed by either single-level locking stand-alone cage (LSC) or anterior plate construct (APC). METHODS: We performed a comprehensive database search of Medline, PubMed, EMBASE and Cochrane Database of Systematic Reviews according to PRISMA guidelines and identified six articles that satisfied our inclusion criteria...
March 10, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28278042/a-cell-attracting-composite-of-lumbar-fusion-cage
#3
Busra Gunay, Nesrin Hasirci, Vasif Hasirci
Lumbar fusion cages are devices used in spinal fusion procedures for disorders such as spondylosis and degenerative disc diseases that may occur due to age, trauma or genetic reasons. These devices are most frequently made of metals and polymers. The mechanical properties of such devices should be comparable to the bone to avoid stress shielding. Besides, cages should interact with the cells to prevent extrusion and achieve satisfactory fusion. In this study, poly(methylmethacrylate) (PMMA) and hydroxyapatite (HAp) were compounded to create products with HAp contents up to 40% (w/w), processed by hot melt extrusion and injection molded to produce composites with maximum polymer-mineral interaction...
March 13, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28272237/risk-factors-for-dysphagia-after-anterior-cervical-spine-surgery-a-meta-analysis
#4
Feng-Yu Liu, Da-Long Yang, Wen-Zheng Huang, Li-Shuang Huo, Lei Ma, Hui Wang, Si-Dong Yang, Wen-Yuan Ding
BACKGROUND: Dysphagia is a well-known complication following anterior cervical spine surgery. Although risk factors for dysphagia have been reported in the literature, they still remain controversial. This study aims to investigate the risk factors associated with dysphagia following anterior cervical spinal surgery. METHODS: PubMed, EMBASE, and The Cochrane Library were searched up to June 2016 for studies examining dysphagia following anterior cervical spinal surgery...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28264242/polyetheretherketone-cage-with-demineralized-bone-matrix-can-replace-iliac-crest-autografts-for-anterior-cervical-discectomy-and-fusion-in-subaxial-cervical-spine-injuries
#5
Soo-Han Kim, Jung-Kil Lee, Jae-Won Jang, Hyun-Woong Park, Hyuk Hur
OBJECTIVE: This study aimed to compare the clinical and radiologic outcomes of patients with subaxial cervical injury who underwent anterior cervical discectomy and fusion (ACDF) with autologous iliac bone graft or polyetheretherketone (PEEK) cages using demineralized bone matrix (DBM). METHODS: From January 2005 to December 2010, 70 patients who underwent one-level ACDF with plate fixation for post-traumatic subaxial cervical spinal injury in a single institution were retrospectively investigated...
March 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28263119/surgical-management-of-pivot-shift-phenomenon-in-a-dog
#6
Rebekah C Knight, David G Thomson, Alan Danielski
CASE DESCRIPTION A 6.8-year-old neutered male Labrador Retriever-Poodle mix was evaluated because of continued left pelvic limb lameness unresponsive to conservative management 1 year after undergoing tibial plateau leveling osteotomy (TPLO). CLINICAL FINDINGS A jerking lateral movement of the left stifle joint was detected during walking. Orthopedic examination revealed a pivot-shift phenomenon (PSP). Palpation elicited no signs of discomfort over the TPLO plate or caudomedial aspect of the stifle joint. Radiography revealed complete bone fusion at the osteotomy site and only mild joint effusion...
March 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28245975/evaluation-of-fixation-techniques-for-metatarsocuneiform-arthrodesis
#7
Eric A Barp, John G Erickson, Hayden L Smith, Katrina Almeida, Kelsey Millonig
First metatarsocuneiform joint arthrodesis has been used in foot and ankle surgery for the treatment of hallux abductovalgus deformity, among other pedal pathologic entities. The goal of the present retrospective study was to compare the fusion rates and complications of an intraplate compression screw fixation, crossing solid core screw fixation, and a single interfragmentary screw with a simple locking plate. All procedures were performed by a single surgeon, and all patients received an identical postoperative protocol...
February 25, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28235698/the-effect-of-anterior-longitudinal-ligament-resection-on-lordosis-correction-during-minimally-invasive-lateral-lumbar-interbody-fusion-biomechanical-and-radiographic-feasibility-of-an-integrated-spacer-plate-interbody-reconstruction-device
#8
Choll Kim, Jonathan A Harris, Aditya Muzumdar, Saif Khalil, Joseph A Sclafani, Kamshad Raiszadeh, Brandon S Bucklen
BACKGROUND: Lateral lumbar interbody fusion is powerful for correcting degenerative conditions, yet sagittal correction remains limited by anterior longitudinal ligament tethering. Although lordosis has been restored via ligament release, biomechanical consequences remain unknown. Investigators examined radiographic and biomechanical of ligament release for restoration of lumbar lordosis. METHODS: Six fresh-frozen human cadaveric spines (L3-S1) were tested: (Miller et al...
February 14, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28222170/biomechanical-investigation-of-two-plating-systems-for-medial-column-fusion-in-foot
#9
Paul Simons, Theresia Sommerer, Ivan Zderic, Dieter Wahl, Mark Lenz, Hristo Skulev, Matthias Knobe, Boyko Gueorguiev, R Geoff Richards, Kajetan Klos
BACKGROUND: Arthrodesis of the medial column (navicular, cuneiform I and metatarsal I) is performed for reasons such as Charcot arthropathy, arthritis, posttraumatic reconstruction or severe pes planus. However, the complication rate is still high and mainly resulting from inadequate fixation. Special plates, designed for medial column arthrodesis, seem to offer potential to reduce the complication rate. The aim of this study was to investigate biomechanically plantar and dorsomedial fusion of the medial column using two new plating systems...
2017: PloS One
https://www.readbyqxmd.com/read/28217804/-changes-of-perimysial-junctional-plates-induced-by-excessive-eccentric%C3%A2-training-and-the-effects-of-acupuncture-intervention
#10
Mei Kong, Xiang Zhang, Mei-Ling Ye, Xue-Lin Zhang
This study aimed to investigate the effects of acupuncture intervention on excessive eccentric training-induced changes of perimysial junctional plates (PJPs) domain. Thirty healthy male Wistar rats were randomly assigned to 5 groups: control group, four-week training group, four-week training + 1-week recovery group and four-week training + 1-week acupuncture group. Rats were subjected to continuous excessive eccentric training for 4 weeks (incline -16°, speed 16-20 m/min, 60-90 min/d, 5 day per week), and then were subjected to one-week spontaneous recovery or one-week recovery with acupuncture intervention (a piece of filiform needle for 4 min every day)...
February 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28216304/ankle-arthrodesis-a-retrospective-analysis-comparing-single-column-locked-anterior-plating-to-crossed-lag-screw-technique
#11
Mark A Prissel, G Alex Simpson, Sean A Sutphen, Christopher F Hyer, Gregory C Berlet
Ankle arthrodesis is performed to eliminate pain due to end-stage osteoarthritis, regardless of etiology. This procedure remains the reference standard treatment for end-stage ankle arthritis, despite recent advancements in total ankle replacement. The objective of the present study was to retrospectively evaluate the radiographic and clinical fusion rates and time to bony fusion for patients who underwent ankle arthrodesis using an anterior approach with a single column locked plate construct versus crossed lag screws...
February 16, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28193216/a-high-throughput-expression-screening-platform-to-optimize-the-production-of-antimicrobial-peptides
#12
Christine Schreiber, Hagen Müller, Oliver Birrenbach, Moritz Klein, Doreen Heerd, Tobias Weidner, Denise Salzig, Peter Czermak
BACKGROUND: Antimicrobial peptides (AMPs) are promising candidates for the development of novel antibiotics, but it is difficult to produce sufficient quantities for preclinical and clinical studies due to their toxicity towards microbial expression hosts. To avoid laborious trial-and-error testing for the identification of suitable expression constructs, we have developed a small-scale expression screening platform based on a combinatorial plasmid library. RESULTS: The combinatorial library is based on the Golden Gate cloning system...
February 13, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28185064/smith-robinson-procedure-with-and-without-caspar-plating-as-a-treatment-for-cervical-spondylotic-myelopathy-a-26-year-follow-up-of-23-patients
#13
Benedikt W Burkhardt, Moritz Brielmaier, Karsten Schwerdtfeger, Salam Sharif, Joachim M Oertel
PURPOSE: The purpose of this study was to assess long-term follow-up data after anterior cervical decompression and fusion (ACDF) with and without Caspar plating (ACDF + PS) for the treatment of cervical spondylotic myelopathy (CSM) with special focus on functional outcome, pain, and repeat surgery for adjacent segment disease (ASD). METHOD: Hospital records of 45 patients who were affected by CSM and underwent ACDF or ACDF + PS at least 17 years ago were reviewed...
February 9, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28167061/chopart-injuries-when-to-fix-and-when-to-fuse
#14
REVIEW
Stefan Rammelt, Tim Schepers
Chopart joint injuries have a profound effect on global foot function. Surgical treatment aims at joint reconstruction and axial alignment with restoration of the normal relationship of the lateral and medial foot columns. Internal fixation is tailored to the individual fracture pattern and achieved with resorbable pins, Kirschner wires, screws, and/or anatomically shaped minifragment plates. If instability persists, temporary joint transfixation may be achieved with Kirschner wires or bridge plating. Primary fusion sacrifices essential joints and should be reserved for severe initial cartilage damage...
March 2017: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/28166805/weight-bearing-recommendations-after-first-metatarsophalangeal-joint-arthrodesis-fixation-a-biomechanical-comparison
#15
Bradley Campbell, Patrick Schimoler, Sudhir Belagaje, M C Miller, S F Conti
BACKGROUND: This study sought to determine whether several metatarsophalangeal (MTP) fusion techniques require complete immobilization or if some level of weight-bearing could be recommended after surgery. A comparison of synthetic composite to actual bone was included in order to examine the validity of the testing conditions. METHODS: Four MTP fusion modalities were tested in synthetic composite bone models: unlocked plating, locked plating, crossed lag screws, and an unlocked plate with a single lag screw...
February 6, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28161640/gastrodin-inhibits-osteoclastogenesis-via-down-regulating-the-nfatc1-signaling-pathway-and-stimulates-osseointegration-in%C3%A2-vitro
#16
Feng Zhou, Yi Shen, Bo Liu, Xia Chen, Lu Wan, Dan Peng
Bone is a rigid yet dynamic organ, and this dynamism is mediated by the delicate balance between osteoclastic bone resorption and osteoblastic bone formation. However, excessive activation of osteoclasts is responsible for many bone diseases such as osteoporosis, Paget disease, and tumor bone metastasis. Agents that could inhibit osteoclast formation or function are regarded as promising alternatives to treat osteoclast-related diseases. Recently, traditional Chinese medicine has attracted attention because of its multiple activities in bone metabolism...
February 2, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28153290/immobilized-fusion-protein-affinity-chromatography-combined-with-hplc-esi-q-tof-ms-ms-for-rapid-screening-of-ppar%C3%AE-ligands-from-natural-products
#17
Junfeng Zhu, Xiaojiao Yi, Wenhui Liu, Yingchun Xu, Shuqing Chen, Yongjiang Wu
Screening agonists of peroxisome proliferator-activated receptor-γ (PPARγ) from natural products is particularly motivated by the need for effective anti-diabetic agents. However, method for direct identification of PPARγ ligands from a complex sample is rarely reported. Here we propose a novel immobilized fusion protein affinity chromatography (IFPAC) to achieve rapid multicomponent screening. First, functional human PPARγ ligand binding domain (hPPARγLBD) was bacterially produced by fusion to glutathione S-transferase (GST)...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28153036/biomechanical-comparison-of-multilevel-lateral-interbody-fusion-with-and-without-supplementary-instrumentation-a-three-dimensional-finite-element-study
#18
Xilin Liu, Jun Ma, Paul Park, Xiaodong Huang, Ning Xie, Xiaojian Ye
BACKGROUND: Lateral lumbar interbody fusion (LLIF) is a popular, minimally invasive technique that is used to address challenging multilevel degenerative spinal diseases. It remains controversial whether supplemental instrumentation should be added for multilevel LLIF. In this study, we compared the kinematic stability afforded by stand-alone lateral cages with those supplemented by bilateral pedicle screws and rods (PSR), unilateral PSR, or lateral plate (LP) fixation using a finite-element (FE) model of a multi-level LLIF construct with simulated osteoporosis...
February 2, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28146025/what-is-the-fate-of-pseudarthrosis-detected-1-year-after-anterior-cervical-discectomy-and-fusion
#19
Dong-Ho Lee, Jae Hwan Cho, Chang Ju Hwang, Choon Sung Lee, Samuel K Cho, Chunghwan Kim, Jung-Ki Ha
STUDY DESIGN: Retrospective comparative study. OBJECTIVE: To investigate the consequences and appropriate management of pseudarthrosis after anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA: Pseudarthrosis is a frequent complication of ACDF and causes unsatisfactory results. Little is known about long-term prognosis of detecting pseudarthrosis 1 year after ACDF. METHODS: Eighty-nine patients with a minimum 2-year follow-up were included...
January 31, 2017: Spine
https://www.readbyqxmd.com/read/28138771/l5-corpectomy-the-lumbosacral-segmental-geometry-and-clinical-outcome-a-consecutive-series-of-14-patients-and-review-of-the-literature
#20
Martin Vazan, Yu-Mi Ryang, Julia Gerhardt, Felix Zibold, Insa Janssen, Florian Ringel, Jens Gempt, Bernhard Meyer
PURPOSE: We analyzed the lumbosacral segmental geometry and clinical outcome in patients undergoing L5 corpectomy. METHODS: Fourteen consecutive patients who underwent L5 (n = 12) or L4 + 5 (n = 2) corpectomy at our department between January 2010 and April 2015 were included. All patients underwent a baseline physical and neurologic examination on admission. The diagnostic routine included MRI and CT scans and, if possible, an upright X-ray of the lumbar spine before and after surgery...
January 31, 2017: Acta Neurochirurgica
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