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https://www.readbyqxmd.com/read/28073140/-clinical-and-radiological-results-after-anterior-cervical-corpectomy-with-cage-fusion-a-retrospective-comparison-of-peek-vs-titanium-cages
#1
Chris Schulz, Uwe Max Mauer, René Mathieu
Background Anterior cervical corpectomy and fusion (ACCF) has become a standard procedure for patients with spondylotic myelopathy due to multisegmental stenosis of the cervical canal. Beside the fusion technique using autogenous bone grafts, synthetic cages have been increasingly used in recent years. Published information on the clinical and radiological results of different cage materials for ACCF is still limited. The study presented here is the largest series to date reporting clinical and radiological outcomes and complication rates after one- to three-level ACCF using structural polyetheretherketone (PEEK) or titanium cages augmented by anterior plate-screw osteosynthesis...
January 10, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28038691/strain-in-posterior-instrumentation-resulted-by-different-combinations-of-posterior-and-anterior-devices-for-long-spine-fusion-constructs
#2
Christopher J Kleck, Damian Illing, Emily M Lindley, Andriy Noshchenko, Vikas V Patel, Cameron Barton, Todd Baldini, Christopher M J Cain, Evalina L Burger
STUDY DESIGN: Clinically related experimental study. OBJECTIVE: Evaluation of strain in posterior low lumbar and spinopelvic instrumentation for multilevel fusion resulting from the impact of such mechanical factors as physiologic motion, different combinations of posterior and anterior instrumentation, and different techniques of interbody device implantation. SUMMARY OF BACKGROUND DATA: Currently different combinations of posterior and anterior instrumentation as well as surgical techniques are used for multilevel lumbar fusion...
January 2017: Spine Deformity
https://www.readbyqxmd.com/read/28034625/patient-specific-biodegradable-implant-in-pediatric-craniofacial-surgery
#3
H Essig, D Lindhorst, T Gander, P Schumann, D Könü, S Altermatt, M Rücker
Surgical correction of premature fusion of calvarial sutures involving the fronto-orbital region can be challenging due to the demanding three-dimensional (3D) anatomy. If fronto-orbital advancement (FOA) is necessary, surgery is typically performed using resorbable plates and screws that are bent manually intraoperatively. A new approach using individually manufactured resorbable implants (KLS Martin Group, Tuttlingen, Germany) is presented in the current paper. Preoperative CT scan data were processed in iPlan (ver...
November 30, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28031502/four-level-anterior-cervical-discectomy-and-fusion-for-cervical-spondylotic-myelopathy
#4
Shan-Jin Wang, Bin Ma, Yu-Feng Huang, Fu-Min Pan, Wei-Dong Zhao, De-Sheng Wu
PURPOSE: To review the outcome of 32 consecutive patients who underwent 4-level anterior cervical discectomy and fusion (ACDF) with cages and plates and were followed up for at least 5 years. METHODS: Records of 19 men and 13 women aged 48 to 69 years who underwent 4-level ACDF with cages and plates for myelopathy (n=11) or myeloradiculopathy (n=21) at C3 to C7 by a single surgeon and were followed up for a minimum of 5 years were reviewed. Clinical outcome was assessed using the visual analogue scale (VAS), Neck Disability Index (NDI), and modified Japanese Orthopaedic Association (JOA) score for pain or myelopathic symptoms...
December 2016: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28017756/a-clinical-comparison-of-anterior-cervical-plates-versus-stand-alone-intervertebral-fusion-devices-for-single-level-anterior-cervical-discectomy-and-fusion-procedures
#5
Ripul R Panchal, Kee D Kim, Robert Eastlack, John Lopez, Andrew Clavenna, Daina M Brooks, Gita Joshua
OBJECTIVE: To compare radiologic and clinical outcomes, including rates of dysphagia and dysphonia, using a no-profile stand-alone intervertebral spacer with integrated screw fixation versus an anterior cervical plate and spacer construct for single-level anterior cervical discectomy and fusion (ACDF) procedures. METHODS: This multicenter, randomized, prospective study included 54 patients with degenerative disc disease (DDD) requiring ACDF at a single level at C3-C7...
December 22, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28013520/protocols-for-screening-antimicrobial-peptides-that-influence-virulence-gene-expression-in-staphylococcus-aureus
#6
Martin Saxtorph Bojer, Mara Baldry, Hanne Ingmer
Compounds that inhibit virulence gene expression in bacterial pathogens have received increasing interest as possible alternatives to the traditional antibiotic treatment of infections. For the human pathogen Staphylococcus aureus, we have developed two simple assays based on reporter gene fusions to central virulence genes that are easily applicable for screening various sources of natural and synthetic peptides for anti-virulence effects. The plate assay is qualitative but simultaneously assesses the effect of gradient concentrations of the investigated compound, whereas the liquid assay is quantitative and can be employed to address whether a compound is acting on the central quorum sensing regulatory system, agr, that controls a large number of virulence genes in S...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28004243/zero-profile-anchored-cage-reduces-risk-of-postoperative-dysphagia-compared-with-cage-with-plate-fixation-after-anterior-cervical-discectomy-and-fusion
#7
REVIEW
ShanWen Xiao, ZhuDe Liang, Wu Wei, JinPei Ning
PURPOSE: To compare the rate of postoperative dysphagia between zero-profile anchored cage fixation (ZPC group) and cage with plate fixation (CP group) after anterior cervical discectomy and fusion (ACDF). METHODS: A meta-analysis of cohort studies between zero-profile anchored cage and conventional cage with plate fixation after ACDF for the treatment of cervical diseases from 2008 to May 2016. An extensive search of studies was performed in PubMed, Medline, Embase, Cochrane library and Google Scholar...
December 21, 2016: European Spine Journal
https://www.readbyqxmd.com/read/28000413/bacteriostatic-behavior-of-surface-modulated-silicon-nitride-in-comparison-to-polyetheretherketone-and-titanium
#8
Ryan M Bock, Erin N Jones, Darin A Ray, B Sonny Bal, Giuseppe Pezzotti, Bryan J McEntire
Perioperative and latent infections are leading causes of revision surgery for orthopaedic devices resulting in significant increased patient care, comorbidities, and attendant costs. Identifying biomaterial surfaces that inherently resist biofilm adhesion and bacterial expression is an important emerging strategy in addressing implant-related infections. This in vitro study was designed to compare biofilm formation on three biomaterials commonly employed in spinal fusion surgery - silicon nitride (Si3 N4 ), polyetheretherketone (PEEK), and a titanium alloy (Ti6Al4V-ELI) - using one gram-positive and one gram-negative bacterial species...
December 21, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27989650/phenotypic-characterization-of-grm1-crv4-mice-reveals-a-functional-role-for-the-type-1-metabotropic-glutamate-receptor-in-bone-mineralization
#9
Ilaria Musante, Deborah Mattinzoli, Lavinia Alexandra Otescu, Simone Bossi, Masami Ikehata, Chiara Gentili, Giuliana Cangemi, Cinzia Gatti, Laura Emionite, Piergiorgio Messa, Roberto Ravazzolo, Maria Pia Rastaldi, Daniela Riccardi, Aldamaria Puliti
Recent increasing evidence supports a role for neuronal type signaling in bone. Specifically glutamate receptors have been found in cells responsible for bone remodeling, namely the osteoblasts and the osteoclasts. While most studies have focused on ionotropic glutamate receptors, the relevance of the metabotropic glutamate signaling in bone is poorly understood. Specifically type 1 metabotropic glutamate (mGlu1) receptors are expressed in bone, but the effect of its ablation on skeletal development has never been investigated...
October 27, 2016: Bone
https://www.readbyqxmd.com/read/27965978/rebamipide-an-amino-acid-analog-of-2-1h-quinolinone-inhibits-the-formation-of-human-osteoclasts
#10
Yuki Nanke, Tsuyoshi Kobashigawa, Toru Yago, Manabu Kawamoto, Hisashi Yamanaka, Shigeru Kotake
Objectives. Drug repositioning or drug reprofiling (DR) has recently been growing in importance. DR has a significant advantage over traditional drug development because the repositioned drug has already passed toxicity tests; its safety is known, and the risk of adverse toxicology is reduced. In the current study, we investigated the role of rebamipide, a mucosa-protecting agent, with recently reported anti-inflammatory function, in human osteoclastogenesis. Methods. Peripheral blood mononuclear cells (PBMCs) were cultured in the presence of M-CSF and sRANKL...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27965512/in-depth-analysis-on-influencing-factors-of-adjacent-segment-degeneration-after-cervical-fusion
#11
Chaojie Yu, Xiaoping Mu, Jianxun Wei, Ye Chu, Bin Liang
BACKGROUND To explore the related influencing factors of adjacent segment degeneration (ASD) after cervical discectomy and fusion (ACDF). MATERIAL AND METHODS A retrospective analysis of 263 patients who underwent ACDF was carried out. Cervical x-ray and magnetic resonance imaging (MRI) were required before operation, after operation, and at the last follow-up. General information and some radiographic parameters of all patients were measured and recorded. According to the imaging data, patients were put into one of two groups: non-ASD group and ASD group...
December 14, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27920332/comparison-of-ankle-fusion-rates-with-and-without-anterior-plate-augmentation
#12
Phillip M Mitchell, Diana G Douleh, A Brian Thomson
BACKGROUND: The optimal fixation construct for tibiotalar arthrodesis continues to be debated. While biomechanical data and clinical series support anterior plate augmentation, comparative studies assessing its use are sparse. The purpose of this study was to compare the rates of successful tibiotalar arthrodesis with and without anterior plate augmentation of a compression screw construct. METHODS: We studied 64 patients (65 ankles) undergoing tibiotalar arthrodesis done by a single surgeon over a 10-year period (2006-2016) with anterior plate augmentation beginning in 2010...
December 5, 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/27910598/analogue-saturation-limit-of-single-and-double-10-mm-microchannel-plate-photomultiplier-tubes
#13
J S Milnes, T M Conneely, C J Horsfield
Photek are a well-established supplier of microchannel plate (MCP) photomultiplier tubes (PMTs) to the inertial confinement fusion community. The analogue signals produced at the major inertial confinement fusion facilities cover many orders of magnitude, therefore understanding the upper saturation limit of MCP-PMTs to large low rate signals takes on a high importance. Here we present a study of a single and a double MCP-PMT with 10 mm diameter active area. The saturation was studied for a range of optical pulse widths from 4 ns to 100 ns and at a range of electron gain values: 10(3) to 10(4) for the single and 10(4) to 10(6) for the double...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910531/a-micro-scale-plasma-spectrometer-for-space-and-plasma-edge-applications-invited
#14
E E Scime, A M Keesee, M Dugas, S Ellison, J Tersteeg, G Wagner, A Barrie, A Rager, D Elliott
A plasma spectrometer design based on advances in lithography and microchip stacking technologies is described. A series of curved plate energy analyzers, with an integrated collimator, is etched into a silicon wafer. Tests of spectrometer elements, the energy analyzer and collimator, were performed with a 5 keV electron beam. The measured collimator transmission and energy selectivity were in good agreement with design targets. A single wafer element could be used as a plasma processing or fusion first wall diagnostic...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910454/development-of-fast-neutron-pinhole-camera-using-nuclear-emulsion-for-neutron-emission-profile-measurement-in-kstar
#15
Y Izumi, H Tomita, Y Nakayama, S Hayashi, K Morishima, M Isobe, M S Cheon, K Ogawa, T Nishitani, T Naka, T Nakano, M Nakamura, T Iguchi
We have developed a compact fast neutron camera based on a stack of nuclear emulsion plates and a pinhole collimator. The camera was installed at J-port of Korea superconducting tokamak advanced research at National Fusion Research Institute, Republic of Korea. Fast neutron images agreed better with calculated ones based on Monte Carlo neutron simulation using the uniform distribution of Deuterium-Deuterium (DD) neutron source in a torus of 40 cm radius.
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910429/automated-analysis-of-hot-spot-x-ray-images-at-the-national-ignition-facility
#16
S F Khan, N Izumi, S Glenn, R Tommasini, L R Benedetti, T Ma, A Pak, G A Kyrala, P Springer, D K Bradley, R P J Town
At the National Ignition Facility, the symmetry of the hot spot of imploding capsules is diagnosed by imaging the emitted x-rays using gated cameras and image plates. The symmetry of an implosion is an important factor in the yield generated from the resulting fusion process. The x-ray images are analyzed by decomposing the image intensity contours into Fourier and Legendre modes. This paper focuses on the additional protocols for the time-integrated shape analysis from image plates. For implosions with temperatures above ∼4 keV, the hard x-ray background can be utilized to infer the temperature of the hot spot...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910419/design-and-fabrication-of-a-window-for-the-gas-cherenkov-detector-3
#17
V E Fatherley, D A Bingham, M D Cartelli, R A DiDomizio, J R Griego, H W Herrmann, F E Lopez, J A Oertel, M J Pollack
The gas Cherenkov detector 3 was designed at Los Alamos National Laboratory for use in inertial confinement fusion experiments at both the Omega Laser Facility and the National Ignition Facility. This instrument uses a low-Z gamma-to-electron convertor plate and high pressure gas to convert MeV gammas into UV/visible Cherenkov photons for fast optical detection. This is a follow-on diagnostic from previous versions, with two notable differences: the pressure of the gas is four times higher, and it allows the use of fluorinated gas, requiring metal seals...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910309/spatial-resolution-measurements-of-the-advanced-radiographic-capability-x-ray-imaging-system-at-energies-relevant-to-compton-radiography
#18
G N Hall, N Izumi, O L Landen, R Tommasini, J P Holder, D Hargrove, D K Bradley, A Lumbard, J G Cruz, K Piston, J J Lee, E Romano, P M Bell, A C Carpenter, N E Palmer, B Felker, V Rekow, F V Allen
Compton radiography provides a means to measure the integrity, ρR and symmetry of the DT fuel in an inertial confinement fusion implosion near peak compression. Upcoming experiments at the National Ignition Facility will use the ARC (Advanced Radiography Capability) laser to drive backlighter sources for Compton radiography experiments and will use the newly commissioned AXIS (ARC X-ray Imaging System) instrument as the detector. AXIS uses a dual-MCP (micro-channel plate) to provide gating and high DQE at the 40-200 keV x-ray range required for Compton radiography, but introduces many effects that contribute to the spatial resolution...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27899848/a-radiographic-analysis-of-cage-positioning-in-lateral-transpsoas-lumbar-interbody-fusion
#19
Timothy L T Siu, Elmira Najafi, Kainu Lin
Direct Lumbar Interbody Fusion (DLIF) and eXtreme Lateral Interbody Fusion (XLIF) are the most common surgical platforms available for performing transpsoas spinal fusion but no study has been carried out to compare them. We evaluated 21 DLIF and 22 XLIF cage positions by measuring the distance between the posterior vertebral border and the centre of the cage normalised to the midsagittal length of the inferior end plate. We found that DLIF cages were significantly more anteriorly located than XLIF (0.65 vs 0...
March 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/27898451/the-effect-of-dynamic-versus-static-plating-systems-on-fusion-rates-and-complications-in-1-level-and-or-2-level-anterior-cervical-discectomy-and-fusion-a-systematic-review
#20
Gregory D Schroeder, Christopher K Kepler, Douglas A Hollern, Ricardo Rodrigues-Pinto, Mark F Kurd, Jefferson R Wilson, Mitchell G Maltenfort, Jonathan T Paul, Andrew N Fleischman, Kathryn Dwight, Paul W Millhouse, Alexander R Vaccaro
STUDY DESIGN: A systematic review. OBJECTIVE: To determine the effect of plate design on fusion rates in patients undergoing a 1- and 2-level anterior cervical discectomy and fusion (ACDF). METHODS: Articles published between January 1, 2002 and January 1, 2015 were systematically reviewed to determine the fusion rate of 1- and 2-level ACDFs using either a fully constrained or semiconstrained locking plate. Additional variables that were collected included the number of levels, the type of graft/cage used, the study design, the method for determining fusion, and complications...
November 28, 2016: Clinical Spine Surgery
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