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https://www.readbyqxmd.com/read/28222170/biomechanical-investigation-of-two-plating-systems-for-medial-column-fusion-in-foot
#1
Paul Simons, Theresia Sommerer, Ivan Zderic, Dieter Wahl, Mark Lenz, Hristo Skulev, Matthias Knobe, Boyko Gueorguiev, R Geoff Richards, Kajetan Klos
BACKGROUND: Arthrodesis of the medial column (navicular, cuneiform I and metatarsal I) is performed for reasons such as Charcot arthropathy, arthritis, posttraumatic reconstruction or severe pes planus. However, the complication rate is still high and mainly resulting from inadequate fixation. Special plates, designed for medial column arthrodesis, seem to offer potential to reduce the complication rate. The aim of this study was to investigate biomechanically plantar and dorsomedial fusion of the medial column using two new plating systems...
2017: PloS One
https://www.readbyqxmd.com/read/28217804/-changes-of-perimysial-junctional-plates-induced-by-excessive-eccentric%C3%A2-training-and-the-effects-of-acupuncture-intervention
#2
Mei Kong, Xiang Zhang, Mei-Ling Ye, Xue-Lin Zhang
This study aimed to investigate the effects of acupuncture intervention on excessive eccentric training-induced changes of perimysial junctional plates (PJPs) domain. Thirty healthy male Wistar rats were randomly assigned to 5 groups: control group, four-week training group, four-week training + 1-week recovery group and four-week training + 1-week acupuncture group. Rats were subjected to continuous excessive eccentric training for 4 weeks (incline -16°, speed 16-20 m/min, 60-90 min/d, 5 day per week), and then were subjected to one-week spontaneous recovery or one-week recovery with acupuncture intervention (a piece of filiform needle for 4 min every day)...
February 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28216304/ankle-arthrodesis-a-retrospective-analysis-comparing-single-column-locked-anterior-plating-to-crossed-lag-screw-technique
#3
Mark A Prissel, G Alex Simpson, Sean A Sutphen, Christopher F Hyer, Gregory C Berlet
Ankle arthrodesis is performed to eliminate pain due to end-stage osteoarthritis, regardless of etiology. This procedure remains the reference standard treatment for end-stage ankle arthritis, despite recent advancements in total ankle replacement. The objective of the present study was to retrospectively evaluate the radiographic and clinical fusion rates and time to bony fusion for patients who underwent ankle arthrodesis using an anterior approach with a single column locked plate construct versus crossed lag screws...
February 16, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28193216/a-high-throughput-expression-screening-platform-to-optimize-the-production-of-antimicrobial-peptides
#4
Christine Schreiber, Hagen Müller, Oliver Birrenbach, Moritz Klein, Doreen Heerd, Tobias Weidner, Denise Salzig, Peter Czermak
BACKGROUND: Antimicrobial peptides (AMPs) are promising candidates for the development of novel antibiotics, but it is difficult to produce sufficient quantities for preclinical and clinical studies due to their toxicity towards microbial expression hosts. To avoid laborious trial-and-error testing for the identification of suitable expression constructs, we have developed a small-scale expression screening platform based on a combinatorial plasmid library. RESULTS: The combinatorial library is based on the Golden Gate cloning system...
February 13, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28185064/smith-robinson-procedure-with-and-without-caspar-plating-as-a-treatment-for-cervical-spondylotic-myelopathy-a-26-year-follow-up-of-23-patients
#5
Benedikt W Burkhardt, Moritz Brielmaier, Karsten Schwerdtfeger, Salam Sharif, Joachim M Oertel
PURPOSE: The purpose of this study was to assess long-term follow-up data after anterior cervical decompression and fusion (ACDF) with and without Caspar plating (ACDF + PS) for the treatment of cervical spondylotic myelopathy (CSM) with special focus on functional outcome, pain, and repeat surgery for adjacent segment disease (ASD). METHOD: Hospital records of 45 patients who were affected by CSM and underwent ACDF or ACDF + PS at least 17 years ago were reviewed...
February 9, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28167061/chopart-injuries-when-to-fix-and-when-to-fuse
#6
REVIEW
Stefan Rammelt, Tim Schepers
Chopart joint injuries have a profound effect on global foot function. Surgical treatment aims at joint reconstruction and axial alignment with restoration of the normal relationship of the lateral and medial foot columns. Internal fixation is tailored to the individual fracture pattern and achieved with resorbable pins, Kirschner wires, screws, and/or anatomically shaped minifragment plates. If instability persists, temporary joint transfixation may be achieved with Kirschner wires or bridge plating. Primary fusion sacrifices essential joints and should be reserved for severe initial cartilage damage...
March 2017: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/28166805/weight-bearing-recommendations-after-first-metatarsophalangeal-joint-arthrodesis-fixation-a-biomechanical-comparison
#7
Bradley Campbell, Patrick Schimoler, Sudhir Belagaje, M C Miller, S F Conti
BACKGROUND: This study sought to determine whether several metatarsophalangeal (MTP) fusion techniques require complete immobilization or if some level of weight-bearing could be recommended after surgery. A comparison of synthetic composite to actual bone was included in order to examine the validity of the testing conditions. METHODS: Four MTP fusion modalities were tested in synthetic composite bone models: unlocked plating, locked plating, crossed lag screws, and an unlocked plate with a single lag screw...
February 6, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28161640/gastrodin-inhibits-osteoclastogenesis-via-down-regulating-the-nfatc1-signaling-pathway-and-stimulates-osseointegration-in%C3%A2-vitro
#8
Feng Zhou, Yi Shen, Bo Liu, Xia Chen, Lu Wan, Dan Peng
Bone is a rigid yet dynamic organ, and this dynamism is mediated by the delicate balance between osteoclastic bone resorption and osteoblastic bone formation. However, excessive activation of osteoclasts is responsible for many bone diseases such as osteoporosis, Paget disease, and tumor bone metastasis. Agents that could inhibit osteoclast formation or function are regarded as promising alternatives to treat osteoclast-related diseases. Recently, traditional Chinese medicine has attracted attention because of its multiple activities in bone metabolism...
February 2, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28153290/immobilized-fusion-protein-affinity-chromatography-combined-with-hplc-esi-q-tof-ms-ms-for-rapid-screening-of-ppar%C3%AE-ligands-from-natural-products
#9
Junfeng Zhu, Xiaojiao Yi, Wenhui Liu, Yingchun Xu, Shuqing Chen, Yongjiang Wu
Screening agonists of peroxisome proliferator-activated receptor-γ (PPARγ) from natural products is particularly motivated by the need for effective anti-diabetic agents. However, method for direct identification of PPARγ ligands from a complex sample is rarely reported. Here we propose a novel immobilized fusion protein affinity chromatography (IFPAC) to achieve rapid multicomponent screening. First, functional human PPARγ ligand binding domain (hPPARγLBD) was bacterially produced by fusion to glutathione S-transferase (GST)...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28153036/biomechanical-comparison-of-multilevel-lateral-interbody-fusion-with-and-without-supplementary-instrumentation-a-three-dimensional-finite-element-study
#10
Xilin Liu, Jun Ma, Paul Park, Xiaodong Huang, Ning Xie, Xiaojian Ye
BACKGROUND: Lateral lumbar interbody fusion (LLIF) is a popular, minimally invasive technique that is used to address challenging multilevel degenerative spinal diseases. It remains controversial whether supplemental instrumentation should be added for multilevel LLIF. In this study, we compared the kinematic stability afforded by stand-alone lateral cages with those supplemented by bilateral pedicle screws and rods (PSR), unilateral PSR, or lateral plate (LP) fixation using a finite-element (FE) model of a multi-level LLIF construct with simulated osteoporosis...
February 2, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28146025/what-is-the-fate-of-pseudarthrosis-detected-1-year-after-anterior-cervical-discectomy-and-fusion
#11
Dong-Ho Lee, Jae Hwan Cho, Chang Ju Hwang, Choon Sung Lee, Samuel K Cho, Chunghwan Kim, Jung-Ki Ha
STUDY DESIGN: Retrospective comparative study. OBJECTIVE: To investigate the consequences and appropriate management of pseudarthrosis after anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA: Pseudarthrosis is a frequent complication of ACDF and causes unsatisfactory results. Little is known about long-term prognosis of detecting pseudarthrosis 1 year after ACDF. METHODS: Eighty-nine patients with a minimum 2-year follow-up were included...
January 31, 2017: Spine
https://www.readbyqxmd.com/read/28138771/l5-corpectomy-the-lumbosacral-segmental-geometry-and-clinical-outcome-a-consecutive-series-of-14-patients-and-review-of-the-literature
#12
Martin Vazan, Yu-Mi Ryang, Julia Gerhardt, Felix Zibold, Insa Janssen, Florian Ringel, Jens Gempt, Bernhard Meyer
PURPOSE: We analyzed the lumbosacral segmental geometry and clinical outcome in patients undergoing L5 corpectomy. METHODS: Fourteen consecutive patients who underwent L5 (n = 12) or L4 + 5 (n = 2) corpectomy at our department between January 2010 and April 2015 were included. All patients underwent a baseline physical and neurologic examination on admission. The diagnostic routine included MRI and CT scans and, if possible, an upright X-ray of the lumbar spine before and after surgery...
January 31, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28132815/shortening-of-microtubule-overlap-regions-defines-membrane-delivery-sites-during-plant-cytokinesis
#13
Jeroen de Keijzer, Henk Kieft, Tijs Ketelaar, Gohta Goshima, Marcel E Janson
Different from animal cells that divide by constriction of the cortex inward, cells of land plants divide by initiating a new cell-wall segment from their center. For this, a disk-shaped, membrane-enclosed precursor termed the cell plate is formed that radially expands toward the parental cell wall [1-3]. The synthesis of the plate starts with the fusion of vesicles into a tubulo-vesicular network [4-6]. Vesicles are putatively delivered to the division plane by transport along microtubules of the bipolar phragmoplast network that guides plate assembly [7-9]...
February 20, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28125523/machine-learning-based-classification-of-38-years-of-spine-related-literature-into-100-research-topics
#14
David C Sing, Lionel N Metz, Stefan Dudli
STUDY DESIGN: Retrospective review. OBJECTIVE: To identify the top 100 spine research topics. SUMMARY OF BACKGROUND DATA: Recent advances in "machine learning," or computers learning without explicit instructions, have yielded broad technological advances. Topic modeling algorithms can be applied to large volumes of text to discover quantifiable themes and trends. METHODS: Abstracts were extracted from the National Library of Medicine PubMed database from five prominent peer-reviewed spine journals (European Spine Journal [ESJ], The Spine Journal [SpineJ], Spine, Journal of Spinal Disorders and Techniques [JSDT], Journal of Neurosurgery: Spine [JNS])...
January 25, 2017: Spine
https://www.readbyqxmd.com/read/28124188/clinical-outcome-and-safety-study-of-a-newly-developed-instrumented-french-door-cervical-laminoplasty-technique
#15
Luigi Aurelio Nasto, Samiul Muquit, Ana Belen Perez-Romera, Hossein Mehdian
BACKGROUND: Standard laminectomy for treatment of cervical myelopathy is associated with secondary instability and kyphosis, while laminectomy combined with fusion puts adjacent segments at risk of degeneration. Single- and double-door laminoplasty techniques have been developed to overcome these limitations. More recently, complications related to bone graft dislodgment have fostered development of hardware-augmented laminoplasty techniques. The aim of this study is to review the clinical safety and effectiveness of a newly developed technique of instrumented French-door laminoplasty for treatment of cervical myelopathy...
January 25, 2017: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/28120067/anterior-cervical-discectomy-and-fusion-with-a-compressive-c-jaws-staple
#16
Lei Xia, Ming-Xing Liu, Jun Zhong, Ning-Ning Dou, Massimiliano Visocchi
BACKGROUND: Anterior cervical discectomy and fusion is currently the most commonly used technique in cervical surgery. But the implantation of a traditional plate is time-consuming and exposes the patient to additional adverse events. In this study, we analyzed results in patients who underwent anterior cervical discectomy and fusion with C-JAWS fixation. The C-JAWS device is a new cervical compressive staple developed to stabilize the spacer. METHODS: At our department, between January 2012 and December 2013, nine consecutive patients with cervical spondylopathy underwent an anterior cervical discectomy and fusion process in which we used a polyether ether ketone cervical spacer prefilled with bone substitute and secured with a cervical compressive staple...
2017: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/28117257/ankle-arthrodesis-using-an-anterior-titanium-dual-locked-plating-construct
#17
Wesley W Flint, Christopher B Hirose, Michael J Coughlin
Ankle arthrodesis is currently the reference standard treatment for end-stage tibiotalar arthrosis. The fusion rates have varied in the published data from 59% to 100%. We reviewed 60 cases of consecutive anterior ankle arthrodesis using an anterior dual locked plating construct with respect to the fusion rate, time to fusion, pain relief, and complications. The patients were followed up for a mean of 1.1 years (range 16 weeks to 4 years). We found that our fusion rate was 97% for ankles not requiring structural allograft...
January 20, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28117195/vomero-premaxillary-joint-a-marker-of-evolution-of-the-species
#18
S Botti, C Rumeau, P Gallet, R Jankowski
OBJECTIVE: According to evolutionary developmental (evo-devo) theory, the vomers are bones derived from the secondary palate. Growth of the palatine processes of the maxillae, including the precursors of vomer bones, results in midline fusion posteriorly to the primary palate, which forces the ascension of the vomer bones towards the primary nasal septum, formed by septal cartilage and the perpendicular plate of the ethmoid. According to this hypothesis, the anterior border of the vomer articulates with the posterior surface of the premaxilla in the incisive canal (IC)...
January 20, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28117081/post-traumatic-forearm-nonunion-in-healthy-skeletally-immature-children-a-report-on-15-cases
#19
Giovanni Luigi Di Gennaro, Stefano Stilli, Giovanni Trisolino
BACKGROUND: Nonunion is a rare but severe complication following forearm fracture in skeletally immature patients. The purpose of this study is to describe a case series of pediatric forearm nonunions treated at our Institute. MATERIALS AND METHOD: We retrospectively reviewed medical charts and radiographs of healthy children affected by post-traumatic nonunion of the forearm, from April 1992 to July 2015. An overall series of 15 cases was included in the study...
January 9, 2017: Injury
https://www.readbyqxmd.com/read/28073140/-clinical-and-radiological-results-after-anterior-cervical-corpectomy-with-cage-fusion-a-retrospective-comparison-of-peek-vs-titanium-cages
#20
Chris Schulz, Uwe Max Mauer, René Mathieu
Background Anterior cervical corpectomy and fusion (ACCF) has become a standard procedure for patients with spondylotic myelopathy due to multisegmental stenosis of the cervical canal. Beside the fusion technique using autogenous bone grafts, synthetic cages have been increasingly used in recent years. Published information on the clinical and radiological results of different cage materials for ACCF is still limited. The study presented here is the largest series to date reporting clinical and radiological outcomes and complication rates after one- to three-level ACCF using structural polyetheretherketone (PEEK) or titanium cages augmented by anterior plate-screw osteosynthesis...
January 10, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
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