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https://www.readbyqxmd.com/read/28542501/a-rho-associated-coiled-coil-containing-kinases-rock-inhibitor-y-27632-enhances-adhesion-viability-and-differentiation-of-human-term-placenta-derived-trophoblasts-in-vitro
#1
Kenichiro Motomura, Naoko Okada, Hideaki Morita, Mariko Hara, Masato Tamari, Keisuke Orimo, Go Matsuda, Ken-Ichi Imadome, Akio Matsuda, Takeshi Nagamatsu, Mikiya Fujieda, Haruhiko Sago, Hirohisa Saito, Kenji Matsumoto
Although human term placenta-derived primary cytotrophoblasts (pCTBs) represent a good human syncytiotrophoblast (STB) model, in vitro culture of pCTBs is not always easily accomplished. Y-27632, a specific inhibitor of Rho-associated coiled-coil containing kinases (ROCK), reportedly prevented apoptosis and improved cell-to-substrate adhesion and culture stability of dissociated cultured human embryonic stem cells and human corneal endothelial cells. The Rho kinase pathway regulates various kinds of cell behavior, some of which are involved in pCTB adhesion and differentiation...
2017: PloS One
https://www.readbyqxmd.com/read/28535008/how-much-medium-do-you-use-for-cell-culture-medium-volume-influences-mineralization-and-osteoclastogenesis-in%C3%A2-vitro
#2
Yoshitaka Yoshimura, Takashi Kikuiri, Tomokazu Hasegawa, Mino Matsuno, Hajime Minamikawa, Yoshiaki Deyama, Kuniaki Suzuki
Bone is maintained by a balance between bone formation and resorption. This remodeling is controlled by a wide variety of systemic and local factors including hormones, cytokines and mechanical stresses. The present in vitro study examined the impact of medium volume, using 0.4, 0.6, 0.8, 1.0, 1.5 and 2.0 ml/well in a 24‑well plate, on the differentiation of osteoblasts and osteoclasts. There were no differences in the alkaline phosphatase activity of osteoblasts amongst the groups; however, the area of mineral deposition was decreased in a media volume‑dependent manner...
May 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28526640/zero-profile-spacer-versus-cage-plate-construct-in-anterior-cervical-discectomy-and-fusion-for-multilevel-cervical-spondylotic-myelopathy-a-systematic-review-and-meta-analysis
#3
Min-Ji Tong, Guang-Heng Xiang, Zi-Li He, De-Heng Chen, Qian Tang, Hua-Zi Xu, Nai-Feng Tian
BACKGROUD: Anterior cervical discectomy and fusion (ACDF) with plate-screw construct has been gradually applied for multilevel cervical spondylotic myelopathy (CSM) in recent years. However, long cervical plate was associated with complications including breakage or loosening of plate and screws, trachea-esophageal injury, neurovascular injury, and postoperative dysphagia. To reduce these complications, the zero-profile spacer has been introduced. This meta-analysis was performed to compared the clinical and radiological outcomes of zero-profile spacer versus cage-plate construct for the treatment of multilevel cervical spondylotic myelopathy...
May 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28525489/minimum-5-year-follow-up-results-for-occipitocervical-fusion-using-the-screw-rod-system-in-craniocervical-instability
#4
Kei Ando, Shiro Imagama, Zenya Ito, Kazuyoshi Kobayashi, Hideki Yagi, Ryuichi Shinjo, Tetsuro Hida, Kenyu Ito, Yoshimoto Ishikawa, Naoki Ishiguro
STUDY DESIGN: Retrospective clinical study. OBJECTIVE: To evaluate the clinical outcome of patients who had undergone occipitocervical (OC) fusion using pedicle screws and rods over a minimum 5-year follow-up. SUMMARY OF BACKGROUND DATA: Few studies have evaluated occipitocervical (OC) fusion using pedicle screws and rods for long-term follow-up. METHODS: Twenty-seven consecutive patients treated underwent posterior OC fusion using pedicle screws and rods over a minimum 5-year follow-up...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28511973/anterior-decompression-and-hybrid-reconstruction-with-titanium-mesh-cage-plus-plate-and-self-locking-stand-alone-cage-for-the-treatment-of-three-level-cervical-spondylotic-myelopathy
#5
Jian Zhou, Xilei Li, Xiaogang Zhou, Hong Lin, Jian Dong
It has been reported that anterior cervical decompression has good clinical outcomes for the treatment of adjacent three-level cervical spondylotic myelopathy (CSM). However, the application of a long plate in the anterior cervical spine poses substantial risks of soft tissue damage. In this retrospective study, we aimed to analyze the clinical and radiological results of the hybrid construction with titanium mesh cage (TMC) plus plate and self-locking stand-alone cage for treatment of adjacent three-level CSM...
May 13, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28507879/traumatic-cervical-unilateral-and-bilateral-facet-dislocations-treated-with-anterior-cervical-discectomy-and-fusion-has-a-low-failure-rate
#6
Alireza K Anissipour, Julie Agel, Matthew Baron, Erik Magnusson, Carlo Bellabarba, Richard J Bransford
STUDY DESIGN: Retrospective radiographic and chart review. OBJECTIVE: To define the rate and associated risk factors of treatment failure of anterior cervical fusion for treatment of cervical facet dislocations. METHODS: Between 2004 and 2014, a retrospective review at a single level 1 trauma center identified 38 patients with unilateral or bilateral dislocated facet(s) treated with anterior cervical discectomy and fusion (ACDF). Two patients were eliminated due to less than 30-day follow-up...
April 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28502688/evaluating-outcomes-of-stand-alone-anterior-lumbar-interbody-fusion-a-systematic-review
#7
Gloria Giang, Ralph Mobbs, Steven Phan, Tommy Manh Tran, Kevin Phan
BACKGROUND: Stand-alone anterior lumbar interbody fusion (ALIF) is an effective surgical approach for selected spinal pathologies. It avoids the morbidity and complications associated with instrumented ALIF such as plate fixation and the traditionally used posterior approach. Despite improved disc space visualisation and clearance, the associated posterior instability and increased risk of non-fusion present major challenges to this approach. The integral cage design aims to address these challenges by providing the necessary stabilisation through intracorporeal screws...
May 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28496111/indirect-meta-analysis-comparing-clinical-outcomes-of-total-cervical-disc-replacements-with-fusions-for-cervical-degenerative-disc-disease
#8
Bin Xu, Jian-Xiong Ma, Jin-Hui Tian, Long Ge, Xin-Long Ma
Anterior cervical discectomy and fusion (ACDF) and total cervical disc replacement (TDR) are considered effective treatments for patients with cervical degenerative disc disease (CDDD). An indirect meta-analysis including 19 randomized controlled trials (5343 patients) was conducted to compare the clinical outcomes of ACDF with TDR. Primary outcomes including functional indicators (NDI [neck disability index] score, neurological success and patient satisfaction), secondary outcomes including surgical outcomes (operation time, blood loss and length of stay) and secondary surgical procedures (secondary surgery at an adjacent level, secondary surgery at the index level, secondary surgery at both levels, removal, reoperation, revision and supplemental fixation) were included in the study...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28471987/pulled-out-locking-screw-re-screwed-spontaneously-in-anterior-cervical-decompression-and-fusion-with-the-zero-profile-implant-system-a-case-report
#9
Yi Yang, Lingli Li, Litai Ma, Junfeng Zeng, Tingkui Wu, Hao Liu
RATIONALE: The zero-profile, standalone device (Zero-P, Synthes GmbH, Switzerland) has been reported to be an effective and safe treatment method with similar clinical outcomes compared with plate. Instrumental complications concerning Zero-P have been little reported. Considering the rarity, we present this amazing case to share with our spinal surgeons and instrument specialists. PATIENT CONCERNS: A 46-year-old man patient presented to our hospital with neck and shoulders pain for 23 years, numbness and weak-ness of right hand for 6 months...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28466094/periosteal-turndown-flap-for-posterior-occipitocervical-fusion-a-technique-review
#10
Siamak Yasmeh, Adrienne Quinn, Liam Harris, Austin E Sanders, Ted Sousa, David L Skaggs, Lindsay M Andras
PURPOSE: Recently, several authors have proposed techniques for improving the fusion rate in pediatric posterior occipitocervical fusion including a variety of implants and the use of bone morphogenetic protein. A technique by Koop et al. using a periosteal flap for occipitocervical arthrodesis was described in 1984. METHODS: A straight incision is made about the posterior neck to expose the occipitocervical region from the inion superiorly to the lowest cervical vertebrae to be fused inferiorly...
May 2, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28465197/effect-of-four-corner-fusion-with-locking-plate-without-bone-graft-on-functional-recovery-of-the-wrist-new-treatment-guidelines
#11
A Tielemans, F Van Innis, S Troussel, C Detrembleur, X Libouton, T Lequint
We assessed the effect of four-corner intercarpal fusion with locking plate without bone graft on daily activities and pain in patients with stage II and III scapholunate advanced collapse and scaphoid nonunion. Twenty-one patients who underwent four-corner fusion with scaphoidectomy without bone graft were evaluated with the Disabilities of the Arm, Shoulder and Hand (QuickDASH) and Visual Analog Scale (VAS) pain scores before and 16 months after surgery. We also compared postoperative grip strength between the operated and the healthy side...
April 5, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28459780/preoperative-radiographic-parameters-to-predict-a-higher-pseudarthrosis-rate-following-anterior-cervical-discectomy-and-fusion
#12
Sung Hoon Choi, Jae Hwan Cho, Chang Ju Hwang, Choon Sung Lee, Hyun Wook Gwak, Dong-Ho Lee
STUDY DESIGN: Retrospective study. OBJECTIVE: To determine whether postoperative pseudarthrosis can be predicted from specific preoperative radiograph measurements. SUMMARY OF BACKGROUND DATA: Various factors reportedly influence the occurrence of pseudarthrosis after anterior cervical discectomy and fusion (ACDF). However, to our knowledge, there are no reports on the relationships between preoperative radiographic parameters and pseudarthrosis...
April 28, 2017: Spine
https://www.readbyqxmd.com/read/28458586/the-roi-c-zero-profile-anchored-spacer-for-anterior-cervical-discectomy-and-fusion-biomechanical-profile-and-clinical-outcomes
#13
Michael N Bucci, Dennis Oh, R Scott Cowan, Reginald J Davis, Robert J Jackson, Dwight S Tyndall, Daniel Nehls
INTRODUCTION: Anterior cervical discectomy and fusion (ACDF) has been the gold standard for treating cervical degenerative disc disease (cDDD). The use of anterior plates in ACDF poses an increased risk of complications such as screw or plate dislodgement, soft tissue injury, esophagus perforation, and dysphagia. The ROI-C™ implant system consists of a zero-profile interbody fusion cage with self-locking plates designed for stand-alone fusion without external plates or screws. OBJECTIVE: The purpose of this report is to describe the ROI-C™ implant system with VerteBRIDGE™ anchor plates, including indications for use, surgical technique, preclinical testing, and clinical study results...
2017: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/28457924/surgical-intervention-for-unstable-craniovertebral-junction-anomalies-with-a-narrow-c2-pedicle
#14
Rami Darwazeh, Qiang Liu, Lei Deng, Jiajie Xia, Mohammed A Elzain, Mazhar Darwazeh, Piyush Sharma, Bo Zhang, Yi Yan
OBJECTIVE: To investigate and report a novel surgical technique of screws insertion and posterior surgical reduction as well as explore its clinical results. METHODS: From September 2008 to September 2012, 41 cases of unstable craniovertebral junction anomalies with a narrow C2 pedicle were treated at our department. All patients underwent "posterior reduction and internal fixation of the occipital bone with superior or inferior articular process of C2 and lateral mass of C3 on the narrowed C2 pedicle side -for non-narrowed C2 pedicle side, the screw was only inserted into C2 pedicle without extending the fixation to C3 vertebrae- using a titanium screw-rod (plate) fixation system"...
April 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28451514/dysphagia-rates-after-anterior-cervical-diskectomy-and-fusion-a-systematic-review-and-meta-analysis
#15
REVIEW
Michael F Shriver, Daniel J Lewis, Varun R Kshettry, Benjamin P Rosenbaum, Edward C Benzel, Thomas E Mroz
STUDY DESIGN:  Systematic review and meta-analysis. OBJECTIVE: Anterior cervical diskectomy and fusion (ACDF) is an effective surgical option for patients with cervical radiculopathy, myelopathy, or deformity. Although ACDF is generally safe, dysphagia is a common complication. Despite its high incidence, prolonged postoperative dysphagia is poorly understood; its etiology remains relatively unknown, and its risk factors are widely debated. METHODS: We searched MEDLINE, Scopus, Web of Science, and Embase for studies reporting complications for cervical diskectomy with plating...
February 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28424853/long-term-results-of-ankle-arthrodesis-in-children-and-adolescents-with-haemophilia
#16
Nicolas de l'Escalopier, Alina Badina, Jean Paul Padovani, Annie Harroche, Laurent Frenzel, Philippe Wicart, Christophe Glorion, Chantal Rothschild
INTRODUCTION: Ankle arthrodesis in patients with haemophilia is a joint-non-preserving treatment option often resulting in substantial pain relief and termination of haemarthrosis by osseous consolidating of the joint. However, limited data are available regarding ankle arthrodesis in young patients. AIM: The aim of this study was to evaluate the long-term clinical and radiographic results with a minimum follow-up of ten years in children with haemophilia who underwent ankle arthrodesis...
April 20, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28414374/practical-dual-band-terahertz-imaging-system
#17
Deliang Zhou, Liwei Hou, Wei Xie, Yuanzhang Zang, Bin Lu, Jian Chen, Peiheng Wu
This paper introduces a dual-band terahertz imaging system as a potential product for nondestructive testing using heterodyne detectors and continuous-wave sources. The operating frequencies of the system are 110.4 and 220.8 GHz. Multiband fusion technology combines the advantages of the greater spatial resolution of the high-frequency band and the enhanced sensitivity of the low-frequency band to improve the detection ability of the system. Additionally, the interference cancellation technology is used to obtain a superior image quality...
April 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/28403693/anterior-retropharyngeal-plate-screw-fixation-with-bilateral-anterior-transarticular-screws-for-odontoid-fractures-a-new-comprehensive-technique
#18
Sushil Patkar
INTRODUCTION: A certain group of odontoid fractures (Anderson and D' Alonzo Type-2) are usually offered surgical treatment. Common surgical option is an anterior odontoid screw. Some of the fractures are not suitable for anterior odontoid screw (anterior oblique, displaced distal fragments and those with atlantoaxial instability) and these are usually offered posterior transarticular screws (Magerl's) or posterior atlantoaxial screw rod/plate fixation (Goel-Harms technique). Posterior surgery involves atlantoaxial fixation with an indirect attempt to reduce and fuse the fracture ...
April 13, 2017: Neurological Research
https://www.readbyqxmd.com/read/28396901/-%C3%A2-biomechanics-of-new-implants-for-hto
#19
D Pape, A Diffo Kaze, A Hoffmann, S Maas
Biomechanical characteristics of 5 tibial osteotomy plates for the treatment of medial knee joint osteoarthritis were examined. Fourth-generation tibial bone composites underwent a medial open-wedge high tibial osteotomy, using TomoFix™ standard, PEEKPower®, ContourLock®, TomoFix™ small stature plates, and iBalance® implants. Static compression load to failure and load-controlled cyclic fatigue failure tests were performed. All plates had sufficient stability up to 2400 N in the static compression load to failure tests...
April 10, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28379913/misaligned-versus-straight-placement-of-anterior-cervical-plates-a-clinical-and-radiologic-outcomes-study
#20
Kingsley R Chin, Fabio J R Pencle, Shannon D Francis, Chloe A Francis, Jason A Seale, Elijah A Hothem
BACKGROUND: In anterior cervical diskectomy and fusion (ACDF), misaligned plates are concerning because of the risk of screw-and-plate failure; however, these plates also hypothetically have the potential for asymmetric micromotion on the facet and uncovertebral joint. The aim of this study was to determine whether misaligned plate placement during ACDF had clinical benefits compared with straight plate placement. METHODS: Postoperative AP radiographs of 128 consecutive patients who underwent ACDF with anterior cervical plate (ACP) fixation were reviewed, and plate alignment was assessed...
May 2017: Journal of the American Academy of Orthopaedic Surgeons
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