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plates for fusion

M Savolainen, A Ritvanen, J Hukki, P Vuola, J Telkkä, J Leikola
Correction of calvarial defects after calvarial vault reconstruction (CVR) is challenging in craniosynostosis patients of advanced age and typically employs autologous bone. Demineralized bone matrix (DBM) is a potential alternative material for autologous bone, but its use has not been extended to correct calvarial defects. CVR patients operated at the Department of Plastic Surgery, Helsinki University Hospital, during 2008-2010 were retrospectively reviewed. Inclusion criteria of the study were CVR patients who received DBM plate, with or without bone dust, on calvarial defects and who had suitable uncovered defect on the contralateral side as control...
September 20, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Peter C Gerszten, Erin Paschel, Hazem Mashaly, Hatem Sabry, Hasan Jalalod'din, Khaled Saoud
BACKGROUND: Anterior cervical discectomy and fusion (ACDF) is a well-accepted treatment option for patients with cervical spine disease. Three- and four-level discectomies are known to be associated with a higher complication rate and lower fusion rate than single-level surgery. This study was performed to evaluate and compare zero-profile fixation and stand-alone PEEK cages for three- and four-level ACDF. METHODS: Two cohorts of patients who underwent ACDF for the treatment of three- and four-level disease were compared...
September 10, 2016: Curēus
Hitoshi Nakayama, Hidetake Kurihara, Yasu S Morita, Taroh Kinoshita, Laura Mauri, Alessandro Prinetti, Sandro Sonnino, Noriko Yokoyama, Hideoki Ogawa, Kenji Takamori, Kazuhisa Iwabuchi
Pathogenic mycobacteria use virulence factors, including mannose-capped lipoarabinomannan (ManLAM), to survive in host phagocytic cells, such as neutrophils. We assessed the roles of lactosylceramide (LacCer, CDw17)-enriched lipid rafts in the phagocytosis of mycobacteria by human neutrophils and in the intracellular fate of phagocytosed mycobacteria. We showed that the association of the Src family kinase (SFK) Lyn with C24 fatty acid chain-containing LacCer was essential for the phagocytosis of mycobacteria by neutrophils...
October 11, 2016: Science Signaling
Wen Huang, Qinbo Qin, Huirong Yang, Shuisheng Li, Chaoqun Hu, Yude Wang, Yong Zhang, Shaojun Liu, Haoran Lin
BACKGROUND: Interspecies hybridization is widely used to achieve heterosis or hybrid vigor, which has been observed and harnessed by breeders for centuries. Natural allopolyploid hybrids generally exhibit more superior heterosis than both the diploid progenies and their parental species. However, polyploid formation processes have been long ignored, the genetic basis of heterosis in polyploids remains elusive. RESULTS: In the present study, triploid hybrids had been demonstrated to contain two sets of chromosomes from mother species and one set from father species...
October 7, 2016: BMC Genetics
Raj D Rao, Donald R Gore, Shu-Jie Tang, Brandon J Rebholz, Narayan Yoganandan, Mei Wang
BACKGROUND: Adjacent segment degeneration frequently develops following anterior cervical discectomy and fusion. The objectives of the present study were to characterize the long-term evolution of degenerative radiographic changes at segments adjacent to anterior cervical fusion and to identify factors associated with the development of these changes, including the preoperative condition of the cervical spine and parameters related to arthrodeses. METHODS: One hundred and sixty-six patients who underwent anterior cervical discectomy and fusion for symptomatic cervical spondylosis or disc herniation were followed radiographically for a mean time of 12...
October 5, 2016: Journal of Bone and Joint Surgery. American Volume
Dong-Ju Yun, Sang-Jin Lee, Sang-Joon Park, Hyeong Seok Oh, Young Jae Lee, Hyun Min Oh, Sang-Ho Lee
BACKGROUND: A new zero-profile, standalone device (Zero P) was recently developed and has shown a lower incidence rate of complications and competitive clinical outcomes compared to CP in single and multi-level ACDF. However, there is still concern whether Zero P is appropriate for multi-level ACDF. In addition, there have been few reports of contiguous two-level ACDF used in conjunction with Zero P. METHODS: We reviewed contiguous two-level ACDF performed from December 2006 to February 2015...
September 23, 2016: World Neurosurgery
Adam H Biedrzycki, Barrie G Grant, Brett Nemke, Samantha L Morello, Mark D Markel
OBJECTIVE To evaluate the biomechanical properties of 4 methods for fusion of the centrodistal and tarsometatarsal joints in horses and compare them among each other and with control tarsi. SAMPLE 24 sets of paired tarsi without substantial signs of osteoarthritis harvested from equine cadavers. PROCEDURES Test constructs (n = 6/type) were prepared from 1 tarsus from each pair to represent surgical drilling; 2 medially to laterally placed kerf-cut cylinders (MLKCs); a single large, dorsally applied kerf-cut cylinder (DKC); and a dorsomedially applied locking compression plate (DMLCP)...
October 2016: American Journal of Veterinary Research
Yuanyuan Chen, Yang Liu, Huajiang Chen, Peng Cao, Wen Yuan
STUDY DESIGN: A retrospective study. OBJECTIVE: To compare clinical and radiologic outcomes of 3-level anterior cervical discectomy and fusion between a zero-profile (Zero-P) spacer and a traditional plate in cases of symptomatic cervical spine spondylosis. SUMMARY OF BACKGROUND DATA: Anterior cervical decompression and fusion is indicated for patients with anterior compression or stenosis of the spinal cord. The Zero-P spacers have been used for anterior cervical interbody fusion of 1 or 2 segments...
September 16, 2016: Clinical Spine Surgery
Amol Saxena, Rajan Patel
Locking plate fixation is becoming more popular for fixation of lower extremity osteotomies. The present study evaluated locking plate fixation compared with screw fixation in the medial displacement calcaneal osteotomy procedure, measuring the outcomes and rate of hardware removal. The procedure was performed on 30 patients, 31 times, with 17 undergoing single screw fixation and 14 undergoing locking plate fixation. The return to activity was 6.87 ± 1.43 months, including some patients for whom running was their main activity...
September 15, 2016: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Kingsley O Abode-Iyamah, Brian J Dlouhy, Alejandro J Lopez, Arnold H Menezes, Patrick W Hitchon, Nader S Dahdaleh
INTRODUCTION: A rigid construct that employs an occipital plate and upper cervical screws and rods is the current standard treatment for craniovertebral junction (CVJ) instability. A rod is contoured to accommodate the occipitocervical angle. Fatigue failure has been associated these acute bends. Hinged rod systems have been developed to obviate intraoperative rod contouring. OBJECT: The aim of this study is to determine the safety and efficacy of the hinged rod system in occipitocervical fusion...
July 2016: Journal of Craniovertebral Junction and Spine
Fan Zhang, Hao-Cheng Xu, Bo Yin, Xin-Lei Xia, Xiao-Sheng Ma, Hong-Li Wang, Jun Yin, Ming-Hao Shao, Fei-Zhou Lyu, Jian-Yuan Jiang
OBJECTIVES: To evaluate the biomechanical characteristics of endplate-conformed cervical cages by finite element method (FEM) analysis and cadaver study. METHODS: Twelve specimens (C2 -C7 ) and a finite element model (C3 -C7 ) were subjected to biomechanical evaluations. In the cadaver study, specimens were randomly assigned to intact (I), endplate-conformed (C) and non-conformed (N) groups with C4-5 discs as the treated segments. The morphologies of the endplate-conformed cages were individualized according to CT images of group C and the cages fabricated with a 3-D printer...
August 2016: Orthopaedic Surgery
David A Tumbarello, Melissa R Andrews, James D Brenton
TGFBI has been shown to sensitize ovarian cancer cells to the cytotoxic effects of paclitaxel via an integrin receptor-mediated mechanism that modulates microtubule stability. Herein, we determine that TGFBI localizes within organized fibrillar structures in mesothelial-derived ECM. We determined that suppression of SPARC expression by shRNA decreased the deposition of TGFBI in mesothelial-derived ECM, without affecting its overall protein expression or secretion. Conversely, overexpression of SPARC increased TGFBI deposition...
2016: PloS One
Tahseen Chaudhry, Michelle Spiteri, Dominic Power, Mark Brewster
AIM: To review the results of our experience with the Medartis Aptus plating system for four corner arthrodesis of the wrist, which uses a combination of compression screws and variable angle locking screws. METHODS: We reviewed the results of 17 procedures in 16 patients that underwent scaphoid excision and four corner fusion using the Medartis Aptus system between May 2010 and June 2014. The primary outcome measure was radiographic and clinical union. RESULTS: The mean clinical follow up time was 20...
August 18, 2016: World Journal of Orthopedics
Ottorino Perrone, Valentina Tassi, Benedetta Mattioli, Niccolò Daddi, Mariella Uneddu, Ignazio Borghesi, Sandro Mattioli
OBJECTIVES: Pharyngo-oesophageal perforation is a rare, life-threatening complication of anterior cervical discectomy and fusion surgery; its management remains poorly defined. We reviewed our experience to understand the treatment of this dreadful complication. METHODS: Data regarding the demographics, clinical course, diagnosis, management and outcomes of 15 cases of pharyngo-oesophageal perforations in 14 patients were collected during the period from 2003 to 2016...
September 11, 2016: European Journal of Cardio-thoracic Surgery
Leonard I Voronov, Krzysztof B Siemionow, Robert M Havey, Gerard Carandang, Avinash G Patwardhan
INTRODUCTION: Lateral mass screw (LMS) fixation with plates or rods is the current standard procedure for posterior cervical fusion. Recently, implants placed between the facet joints have become available as an alternative to LMS or transfacet screws for patients with cervical spondylotic radiculopathy. The purpose of this study was to evaluate the biomechanical stability of the DTRAX(®) cervical cage for single- and two-level fusion and compare this to the stability achieved with LMS fixation with rods in a two-level construct...
2016: Medical Devices: Evidence and Research
Chunyue Duan, Jianzhong Hu, Xiyang Wang, Jianhuang Wu
OBJECTIVE: To explore the clinical value of early and one-stage posterior laminectomy decompression, fracture reconstruction and lateral mess screw fixation combined with anterior cervical corpectomy or discectomy for the treatment of fresh and severe lower cervical spine fracture and dislocation.
 METHODS: A total of 156 consecutive cases of severe fracture and dislocation of lower cervical spine were reviewed from January 2008 to January 2015. Skull traction was installed when the patients were enrolled in the hospital, so the operation was performed as early as possible...
August 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Emily J Morrison, Alan S Litsky, Matthew J Allen, Geoffrey T Fosgate, Bianca F Hettlich
OBJECTIVE: To assess technical feasibility and mechanical properties of 3 locking plate designs (Zero-P, Zero-P VA, and Uniplate 2) for use in the canine cervical spine. STUDY DESIGN: Prospective ex vivo study. ANIMALS: Cadaver cervical spines from skeletally mature large breed dogs (n = 18). METHODS: Specimens were screened using radiography and allocated into balanced groups based on bone density. Stiffness of intact C4-C5 vertebral motion units was measured in extension, flexion, and lateral bending using nondestructive 4-point bend testing...
October 2016: Veterinary Surgery: VS
Jan-Falco Wilbrand, Hans-Peter Howaldt, Marcus Reinges, Petros Christophis
OBJECTIVE: Premature craniosynostosis of the lambdoid suture is rare. The use of differential diagnosis to rule out positional occipital plagiocephaly is crucial. Nevertheless, once diagnosed, lambdoid craniosynostosis requires corrective surgery to prevent intracranial harm and aesthetic stigma by significant dyscrania. Operative correction of the lambdoid fusion is often performed by suturectomy and helmet therapy, total occipital remodeling interventions, transposition of occipital bone flaps, or occipital advancement procedures either with or without distraction osteogenesis...
August 6, 2016: Journal of Cranio-maxillo-facial Surgery
Calisir Bunyamin, Ulutas Murat, Boyaci Suat, Aksoy Kaya
AIM: Fusion development is the primary objective in spinal surgeries that are conducted for the treatment of vertebra corpus related pathologies such as trauma, tumor and infection. Stabilization using metal plate screws together either with autograft, allograft or xenografts methods are used. Fusion development in stabilizations that are carried out with xenograft (XG) with XG plate-screw (XPS) and XG with metal plate-screw (MPS) systems in dogs' lumbar vertebra (L5-7 segment) was examined in terms of radiology, biomechanics and histopathologic aspects...
June 24, 2016: Turkish Neurosurgery
Tao Zhang, Ying Guo, Naiwu Hu, Limin Chen, Yin Wu, Yang Wang, Libing Liu, Chengbin Zhao
This retrospective study assessed the outcomes of segmental subtotal corpectomy with titanium cage reconstruction and anterior plate fixation for multilevel ossification of the posterior longitudinal ligament. The study included 34 patients with multilevel ossification of the posterior longitudinal ligament who underwent segmental subtotal corpectomy with titanium cage reconstruction and anterior plate fixation from June 2005 to May 2011. Clinical and radiologic data were obtained. Neurologic function was evaluated by Japanese Orthopedic Association scores before and after surgery...
August 30, 2016: Orthopedics
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