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https://www.readbyqxmd.com/read/29731694/the-role-of-some-adam-proteins-and-activation-of-the-insulin-growth-factor-related-pathway-in-colorectal-cancer
#1
REVIEW
Katarzyna Walkiewicz, Ewa Nowakowska-Zajdel, Paweł Kozieł, Małgorzata Muc-Wierzgoń
Colorectal cancer (CRC) is the third most common malignant neoplasm worldwide. In Poland, colorectal cancer ranks second in tumor incidence regardless of sex; moreover, there has been a steady increase in the incidence of CRC. CRC results from complex interactions between inherited susceptibility, clinical conditions and environmental/lifestyle-related risk factors such as physical inactivity, smoking, alcohol consumption, high-fat/low-fiber diet, and obesity/overweight. The activation of pathways associated with insulin resistance and insulin-like growth factors (IGF) appears to be the epidemiological link between the metabolic syndrome and the development of CRC, which is of particular importance...
2018: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29699897/development-of-regional-extracorporeal-life-support-system-the-importance-of-innovative-simulation-training
#2
Mateusz Puślecki, Marcin Ligowski, Marek Dąbrowski, Sebastian Stefaniak, Małgorzata Ładzińska, Aleksander Pawlak, Marcin Zieliński, Łukasz Szarpak, Bartłomiej Perek, Marek Jemielity
BACKGROUND: Despite advances in mechanical ventilation, severe acute respiratory distress syndrome (ARDS) is associated with high morbidity and mortality rates ranging from 30% to 60%. Extracorporeal Membrane Oxygenation (ECMO) can be used as a "bridge to recovery". ECMO is a complex network that provides oxygenation and ventilation and allows the lungs to rest and recover from respiratory failure, while minimizing iatrogenic ventilator-induced lung injury. In the critical care settings, ECMO is shown to improve survival rates and outcomes in patients with severe ARDS...
April 18, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29692221/temporal-trends-in-secondary-prevention-in-myocardial-infarction-patients-discharged-with-left-ventricular-systolic-dysfunction-in-poland
#3
Mariusz Gasior, Marek Gierlotka, Łukasz Pyka, Tomasz Zdrojewski, Bogdan Wojtyniak, Krzysztof Chlebus, Piotr Rozentryt, Jacek Niedziela, Piotr Jankowski, Jadwiga Nessler, Grzegorz Opolski, Piotr Hoffman, Ewa Jankowska, Lech Polonski, Piotr Ponikowski
Background The proportion of patients discharged after myocardial infarction with left ventricular systolic dysfunction remains high and the prognosis is unfavourable. The aim of this study was to analyse the temporal trends in the treatment and outcomes of a nationwide cohort of patients. Methods and results Data from the Polish Registry of Acute Coronary Syndromes and Acute Myocardial Infarction in Poland Registry were combined to achieve complete information on inhospital course, treatment and outcomes. An all-comer population of patients discharged with left ventricular ejection fraction of 40% or less formed the sample population ( n = 28,080)...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29628510/adaptive-and-maladaptive-perfectionism-and-professional-burnout-among-medical-laboratory-scientists
#4
Marlena Robakowska, Anna Tyrańska-Fobke, Maciej Walkiewicz, Małgorzata Tartas
BACKGROUND: The goal of this paper is to verify the correlations between adaptive and maladaptive perfectionism and the selected demographic and job characteristics vs. professional burnout among medical laboratory scientists in Poland. MATERIAL AND METHODS: The study group consisted of 166 laboratory scientists. The Polish Adaptive and Maladaptive Perfectionism Questionnaire (Szczucka) was used for testing perfectionism. The Oldenburg Burnout Inventory was used for examining burnout syndrome...
April 9, 2018: Medycyna Pracy
https://www.readbyqxmd.com/read/29513249/comparison-of-objective-and-subjective-evaluation-of-breast-symmetrization-results-in-patients-with-poland-syndrome
#5
Anna Kasielska-Trojan, Tomasz Zieliński, Paweł Pisera, Bogusław Antoszewski
INTRODUCTION: There are many methods of analyzing the appearance of the breasts, but most of them are based on the patient's subjective assessment or on the opinion of a specialist panel. Anthropometric measurements enable objective breast evaluation. The aim of the study was to compare the objective and subjective evaluation of aesthetic results of breast symmetrization in patients with Poland syndrome. MATERIAL AND METHODS: The analysis of the results of the treatment was performed in 7 patients treated surgically due to unilateral breast underdevelopment in Poland syndrome...
February 28, 2018: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/29512628/analysis-of-chronic-illnesses-and-disability-in-a-community-based-sample-of-elderly-people-in-south-eastern-poland
#6
Agnieszka Ćwirlej-Sozańska, Anna Wilmowska-Pietruszyńska, Bernard Sozański, Agnieszka Wiśniowska-Szurlej
BACKGROUND The proportion of elderly people living in Poland has risen in recent years. With rising life expectancy, there is likely to be a concurrent increase in the incidence of chronic diseases and disabilities. Therefore, this study aimed to analyze the prevalence of chronic diseases and disability of the elderly in order to help guide strategies of prevention and public health control. MATERIAL AND METHODS This was a cross-sectional study of 1,000 randomly-selected residents living in the Podkarpackie region of Poland...
March 7, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29499372/frailty-and-health-status-of-older-individuals-in-three-european-countries-the-courage-cross-sectional-study
#7
Stefanos Tyrovolas, Noe Garin Escriva, Jose Luis Ayuso-Mateos, Somnath Chatterji, Ai Koyanagi, Marta Miret, Maria Victoria Moneta, Beatriz Olaya, Beata Tobiasz-Adamczyk, Seppo Koskinen, Matilde Leonardi, Josep Maria Haro
BACKGROUND AND AIM: Frailty is characterized by several deficits in multiple health related domains. Although cognition is among the important components of frailty, there is lack of evidence on the role of specific neuro-cognitive dimensions. The primary aim of the present work was to evaluate the multidimensional definition of frailty, and to assess whether neuro-cognitive function is a constituent of the frailty syndrome among adults aged ≥50 years living in three European countries...
June 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29470449/determinants-of-quality-of-life-and-satisfaction-with-life-in-women-with-polycystic-ovary-syndrome
#8
Ewa Rzońca, Agnieszka Bień, Artur Wdowiak, Ryszard Szymański, Grażyna Iwanowicz-Palus
The purpose of the study was to assess the quality of life (QoL) and satisfaction with life (SwL) of women with polycystic ovary syndrome (PCOS) in comparison with those of healthy controls, and to identify and analyze factors determining QoL and SwL in women with PCOS. The cross-sectional study was performed between January and November 2016 in 504 women using health care services in Poland. The study group comprised women with PCOS, the control group women without PCOS. The study used a diagnostic survey with questionnaires...
February 22, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29463957/adenomas-genetic-factors-in-colorectal-cancer-prevention
#9
REVIEW
Kycler Witold, Kubiak Anna, Trojanowski Maciej, Janowski Jakub
Colorectal cancer is the second most common type of cancer both in Europe and Poland. During the last 30 years more than a 3-fold increase has been observed in Poland due to environmental and genetic factors. Almost all colorectal malignancies are related to the formation and malignant transformation of colorectal dysplasia and adenoma. Efforts aiming to decrease the number of colorectal cancer deaths are focused on the disease early detection. Genetic diagnosis for hereditary syndromes predisposing to colorectal cancer has been developed and is a part of the routine treatment...
March 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29457624/-coordinated-heart-failure-care-in-poland-towards-optimal-organisation-of-the-health-care-system
#10
Jadwiga Nessler, Adam Kozierkiewicz, Andrzej Gackowski, Piotr Ponikowski, Ewa Straburzynska-Migaj, Izabella Uchmanowicz, Piotr Hoffman, Krzysztof Chlebus, Grzegorz Gielerak, Mariusz Gąsior, Tomasz Grodzicki, Jakub Gierczyński, Piotr Jankowski, Jarosław Kaźmierczak, Jacek Legutko, Przemysław Leszek, Maciej Miłkowski, Grzegorz Opolski, Piotr Rozentryt, Adam Windak, Adam Witkowski, Mirosław J Wysocki, Andrzej Zapaśnik, Tomasz Zdrojewski
Heart failure has becoming an increasing medical, economic, and social problem globally. The prevalence of this syndrome is rising, and despite unequivocal positive effects of modern therapy, reduction of mortality has been achieved at the cost of more frequent hospitalisations. Unlike in many European countries, in Poland heart failure is usually recognised later, at a more advanced stage of the disease, leaving less time for ambulatory treatment and resulting in a high number of hospitalisations. The current paper presents the most important data regarding morbidity and mortality due to heart failure in Poland...
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29453822/full-genome-sequencing-of-porcine-circovirus-3-field-strains-from-denmark-italy-and-spain-demonstrates-a-high-within-europe-genetic-heterogeneity
#11
G Franzo, M Legnardi, C K Hjulsager, F Klaumann, L E Larsen, J Segales, M Drigo
Porcine circovirus 3 (PCV3) is a new species of the Circovirus genus, which has recently been associated with different clinical syndromes. Its presence has been reported in different countries of North and South America, Asia and recently also Europe (Poland). However, different from the other continents, no European PCV3 sequence is currently available in public databases. There is a strong need of epidemiological data and full-genome sequences from Europe because of its relevance in the understanding of PCV3 molecular epidemiology and control...
June 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29407882/the-cost-effectiveness-of-screening-strategies-for-familial-hypercholesterolaemia-in-poland
#12
Aleksandra Pelczarska, Michał Jakubczyk, Joanna Jakubiak-Lasocka, Maciej Banach, Małgorzata Myśliwiec, Marcin Gruchała, Maciej Niewada
BACKGROUND AND AIMS: Familial hypercholesterolaemia (FH) elevates the cholesterol level and increases the risk of coronary events and death. Early detection and treatment reduce this risk. We aimed to determine the cost-effectiveness of FH screening in Poland in children, first job takers, and after an acute coronary syndrome (ACS) event, each followed by a cascade screening in the relatives of the positively-diagnosed subjects. METHODS: A decision tree was constructed to model the diagnosis process...
March 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29399772/expert-consensus-on-the-usefulness-of-natriuretic-peptides-in-heart-failure
#13
Jadwiga Nessler, Ewa Straburzyńska-Migaj, Adam Windak, Bogdan Solnica, Maciej Szmitkowski, Marek Paradowski, Jarosław Kaźmierczak, Elżbieta Puacz, Piotr Rozentryt
Heart failure (HF) has becoming an increasing clinical and social problem worldwide and despite modern therapy the syndrome still imposes high burden on healthcare systems. In contrast to western countries, the diagnosis of HF in Poland is established later, at more advanced stage of the disease, thus leaving less time for modern therapy and more frequently requiring hospitalisation. As a result, the alarmingly high proportion of patients with HF is treated in hospitals in Poland. According to current guidelines clinical suspicion of HF should be verified based on early assessment of plasma levels of natriuretic peptides...
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29396004/development-of-vaccines-against-zika-virus
#14
REVIEW
Gregory A Poland, Richard B Kennedy, Inna G Ovsyannikova, Ricardo Palacios, Paulo Lee Ho, Jorge Kalil
Zika virus is an emerging pathogen of substantial public health concern to human beings. Although most infections are asymptomatic or present with benign, self-limited symptoms, a small percentage of patients have complications, such as congenital anomalies in the developing fetus of pregnant women infected with the virus and neurological complications (eg, Guillain-Barré syndrome). To date, there is no vaccine, antiviral drug, or other modality available to prevent or treat Zika virus infection. In this Review, we examine vaccine development efforts for Zika virus to date and research gaps in the development of candidate vaccines against Zika virus...
January 25, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29395273/cannabidiol-in-patients-with-seizures-associated-with-lennox-gastaut-syndrome-gwpcare4-a-randomised-double-blind-placebo-controlled-phase-3-trial
#15
Elizabeth A Thiele, Eric D Marsh, Jacqueline A French, Maria Mazurkiewicz-Beldzinska, Selim R Benbadis, Charuta Joshi, Paul D Lyons, Adam Taylor, Claire Roberts, Kenneth Sommerville
BACKGROUND: Patients with Lennox-Gastaut syndrome, a rare, severe form of epileptic encephalopathy, are frequently treatment resistant to available medications. No controlled studies have investigated the use of cannabidiol for patients with seizures associated with Lennox-Gastaut syndrome. We therefore assessed the efficacy and safety of cannabidiol as an add-on anticonvulsant therapy in this population of patients. METHODS: In this randomised, double-blind, placebo-controlled trial done at 24 clinical sites in the USA, the Netherlands, and Poland, we investigated the efficacy of cannabidiol as add-on therapy for drop seizures in patients with treatment-resistant Lennox-Gastaut syndrome...
March 17, 2018: Lancet
https://www.readbyqxmd.com/read/29350395/early-results-of-aortic-arch-reconstruction-and-bilateral-pulmonary-artery-banding-modification-of-the-norwood-operation-for-treatment-of-hypoplastic-left-heart-syndrome
#16
Jacek W Pająk, Michał Buczyński, Piotr Stanek, Grzegorz Zalewski, Marek Wites, Lesław Szydłowski, Lidia Tomkiewicz-Pająk
BACKGROUND: In the period from 2003 to the end of 2015, 96 Norwood I procedures were performed in the Paediatric Heart Surgery Department in Katowice, Poland, in children with hypoplastic left heart syndrome (HLHS). AIM: This paper presents a retrospective analysis of early surgical results. METHODS: The patients consisted of two groups: group I included 59 children operated on in the years 2003-2012, in whom the stage I Norwood procedure with the Sano modification was performed with the aortic arch reconstructed by use of a ho-mogenous pulmonary artery patch or a bovine pericardial patch...
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29350382/risk-factors-for-adverse-outcomes-of-acute-coronary-syndrome-patients-single-center-experience-in-long-term-follow-up-of-treated-patients
#17
Marcin Grabowski, Krzysztof J Filipiak, Grzegorz Opolski, Renata Główczyńska, Monika Gawałko, Paweł Balsam, Andrzej Cacko, Zenon Huczek, Grzegorz Karpiński, Robert Kowalik, Franciszek Majstrak, Janusz Kochman
BACKGROUND: For patients experiencing an acute coronary syndrome (ACS), a crucial time to assess their prognosis and future management is at discharge from hospital. AIM: To identify patients' risk factors of mortality during post-discharge period following an ACS hospitalization. METHODS: We studied 672 consecutive ACS patients hospitalized and discharged alive between 2002 and 2004. The analysis was done in respect of the type of ACS, i...
January 19, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29350379/metabolic-syndrome-in-hiv-infected-adults-in-poland
#18
Magdalena Rogalska-Płońska, Anna Grzeszczuk, Paweł Rogalski, Mariusz Łucejko, Robert Flisiak
BACKGROUND: Metabolic syndrome (MS) is usually diagnosed based on the presence of abdominal obesity, elevated blood pres-sure (BP), elevated fasting plasma glucose, high serum triglycerides (TG), and low high-density lipoprotein (HDL) cholesterol levels. Whether HIV is associated with a higher prevalence of MS than in the general population remains unclear. AIM: The aim of the study was to determine the incidence of MS in the population of HIV-infected adults and its association with clinical, virological, and biochemical features...
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29331967/understanding-frailty-a-qualitative-study-of-european-healthcare-policy-makers-approaches-to-frailty-screening-and-management
#19
Holly Gwyther, Rachel Shaw, Eva-Amparo Jaime Dauden, Barbara D'Avanzo, Donata Kurpas, Maria Bujnowska-Fedak, Tomasz Kujawa, Maura Marcucci, Antonio Cano, Carol Holland
OBJECTIVE: To elicit European healthcare policy-makers' views, understanding and attitudes about the implementation of frailty screening and management strategies and responses to stakeholders' views. DESIGN: Thematic analysis of semistructured qualitative interviews. SETTING: European healthcare policy departments. PARTICIPANTS: Seven European healthcare policy-makers representing the European Union (n=2), UK (n=2), Italy (n=1), Spain (n=1) and Poland (n=1)...
January 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29313559/the-long-term-prognosis-following-acute-coronary-syndromes-a-prospective-observational-study-of-unselected-group-treated-in-the-24-7-cardiac-catheterization-laboratory-at-university-hospital
#20
Marcin Grabowski, Krzysztof J Filipiak, Grzegorz Opolski, Renata Główczyńska, Monika Gawałko, Paweł Balsam, Andrzej Cacko, Zenon Huczek, Grzegorz Karpiński, Robert Kowalik, Franciszek Majstrak, Janusz Kochman
BACKGROUND: The risk stratification in acute coronary syndrome (ACS) is usually based on the clinical data obtained during hospitalization. To date, there is a limited number of prospective observational studies assessing long-term prognosis of patients discharged from the hospital after ACS. AIM: This study is to investigate long-term follow-up of unselected ACS patients treated at the 24 hours/7 days (24/7) cardiac catheterization laboratory and discharged from referral, university hospital...
January 9, 2018: Kardiologia Polska
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