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https://www.readbyqxmd.com/read/29778207/evolution-in-europe-of-african-swine-fever-genotype-ii-viruses-from-highly-to-moderately-virulent
#1
Gallardo C, Nurmoja I, Soler A, Delicado V, Simón A, Martin E, Perez C, Nieto R, Arias M
Since its arrival in the Caucasus and Russia in 2007, African swine fever virus (ASFV) has spread widely and has now affected the EU countries of Estonia, Latvia, Lithuania, Poland and, more recently, the Czech Republic and Romania. The ever-increasing evidence of seropositive wild boar in certain areas suggests that some animals may be surviving for some time or could even be recovering from the disease. This could be due to acquired immunity after the primary infection and/or the presence of related viruses of reduced virulence...
June 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29773946/utility-of-the-care-dependency-scale-in-predicting-care-needs-and-health-risks-of-elderly-patients-admitted-to-a-geriatric-unit-a-cross-sectional-study-of-200-consecutive-patients
#2
Halina Doroszkiewicz, Matylda Sierakowska, Marta Muszalik
Objective: The aim of the study was to evaluate the usefulness of the Polish version of the Care Dependency Scale (CDS) in predicting care needs and health risks of elderly patients admitted to a geriatric unit. Methods: This was a cross-sectional study of 200 geriatric patients aged ≥60 years, chronologically admitted to a geriatrics unit in Poland. The study was carried out using the Polish version of the CDS questionnaire to evaluate biopsychosocial needs and the level of care dependency...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29771638/the-first-report-evaluating-the-post-exposure-rabies-prophylaxis-in-children-exposed-to-animals-in-the-lublin-province-eastern-poland-in-2010-2016-a-retrospective-study
#3
Joanna Krzowska-Firych, Ewelina Mazurek, Barbara Hasiec, Krzysztof Tomasiewicz
INTRODUCTION: Rabies continues to be one of the most important viral diseases and remains a significant threat to public health across the globe. The World Health Organization (WHO) has determined that most rabies cases occur in children. Dog bites on humans are a major public-health problem. Poland has not achieved rabies free status yet. Post-exposure prophylaxis (PEP) in humans can effectively prevent death after exposure to a potentially infected animal. THE AIM: The main objective of this study was to estimate the frequency of PEP among children exposed to animals, who had attended consultations at the Department of Infectious Diseases for Children in the Jan Boży Hospital in Lublin...
May 17, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29766700/health-policy-programs-realised-in-poland-in-2016-2017
#4
Patrycja Kurowska, Anna Królak, Wojciech Giermaziak
Background: Health Policy Program (Program Polityki Zdrowotnej – PPZ) is a state policy tool for engaging local government units into the mechanism of granting provision of health services. Authors show areas in which self-governments most often took preventive health care actions and describe legislative changes in the Act on provision of health services. Objective: The aim of the article is to quantitative and qualitative statement of PPZ prepared in Poland in 2016 and 2017, as well as presenting changing legal situation in the scope of evaluation of these projects...
2018: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/29765444/sequentiality-of-treatment-in-the-rheumatoid-arthritis-drug-programme-in-the-years-2009-2014
#5
Małgorzata Tłustochowicz, Andrzej M Śliwczyński, Melania Brzozowska, Zbigniew Teter, Michał Marczak
Approximately 1% of the population suffers from rheumatoid arthritis (RA) worldwide (0.45% in Poland). The therapy consists of the use of disease-modifying antirheumatic drugs (DMARDs). Biologics are used in the form of the drug programme. Analysis of the NHF database demonstrated the sequence of conversion between drugs and time spent in a single treatment. In 2009, the patients would start the following treatments: adalimumab 5.8%; etanercept 14.4%; infliximab 23.1%; leflunomide 53.6%; rituximab 3%. After the first year 16% of patients changed therapy or abstained, and in the second year this situation affected 65% of patients...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29763671/searching-for-signals-of-recent-natural-selection-in-genes-of-the-innate-immune-response-ancient-dna-study
#6
Magda Lewandowska, Krystyna Jędrychowska-Dańska, Tomasz Płoszaj, Piotr Witas, Alicja Zamerska, Hanna Mańkowska-Pliszka, Henryk W Witas
The last decade has seen sharp progress in the field of human evolutionary genetics and a great amount of genetic evidence of natural selection has been provided so far. Since host-pathogen co-evolution is difficult to trace due to the polygenic nature of human susceptibility to microbial diseases, of particular interest is any signal of natural selection in response to the strong selective pressure exerted by pathogens. Analysis of ancient DNA allows for the direct insight into changes of a gene pool content over time and enables monitoring allele frequency fluctuations...
May 12, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29753319/biotransformation-of-steroids-by-entomopathogenic-strains-of-isaria-farinosa
#7
Ewa Kozłowska, Natalia Hoc, Jordan Sycz, Monika Urbaniak, Monika Dymarska, Jakub Grzeszczuk, Edyta Kostrzewa-Susłow, Łukasz Stępień, Elżbieta Pląskowska, Tomasz Janeczko
BACKGROUND: Steroid compounds are very interesting substrates for biotransformation due to their high biological activity and a high number of inactivated carbons which make chemical modification difficult. Microbial transformation can involve reactions which are complicated and uneconomical in chemical synthesis, and searching for a new effective biocatalyst is necessary. The best known entomopathogenic species used in steroid modification is Beauveria bassiana. In this study we tested the ability of Isaria farinosa, another entomopathogenic species, to transform several steroids...
May 12, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29752708/coexistence-of-chronic-bronchitis-in-chronic-obstructive-lung-disease
#8
Filip Mejza, Paweł Nastałek, Agnieszka Mastalerz-Migas, Zbigniew Doniec, Wojciech Skucha
The incidence of chronic obstructive pulmonary disease (COPD) is on the rise worldwide. Chronic bronchitis is a frequent accompaniment of COPD, which increases the burden of COPD in affected individuals. The aim of this study was to characterize the phenotype of chronic bronchitis in COPD patients. The study was based on the survey data retrospectively retrieved from the Action Health-Lung Cancer Prophylaxis and Health Care Improvement screening program that concerned all the inhabitants, aged over 40, of the Proszowice administrative region situated in the Lesser Poland Voivodeship in southern Poland...
May 12, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29728122/trends-in-mortality-from-pneumonia-in-the-europe-union-a-temporal-analysis-of-the-european-detailed-mortality-database-between-2001-and-2014
#9
Dominic C Marshall, Ross J Goodson, Yiwang Xu, Matthieu Komorowski, Joseph Shalhoub, Mahiben Maruthappu, Justin D Salciccioli
BACKGROUND: Pneumonia is responsible for approximately 230,000 deaths in Europe, annually. Comprehensive and comparable reports on pneumonia mortality trends across the European Union (EU) are lacking. METHODS: A temporal analysis of national mortality statistics to compare trends in pneumonia age-standardised death rates (ASDR) of EU countries between 2001 and 2014 was performed. International Classification of Diseases version 10 (ICD-10) codes were used to extract data from the World Health Organisation European Detailed Mortality Database and trends were analysed using Joinpoint regression...
May 4, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29718911/mental-distress-and-perceived-wealth-justice-and-freedom-across-eight-countries-the-invisible-power-of-the-macrosystem
#10
Saskia Scholten, Julia Velten, Jürgen Margraf
Health and well-being have been related to macro-level factors such as income, income inequality or socioeconomic status. With regard to the increasing burden of disease due to mental disorders worldwide, the association between the macrosystem and mental distress should be further explored, too. In this context, the subjective evaluation of the macrosystem might play an important role. In the present exploratory study, we assessed symptoms of depression, anxiety and stress as well as perceived wealth, justice and freedom in population-based surveys in Spain, France, Germany, Poland, Russia, Sweden, the United Kingdom and the United States of America (n ≈ 1000 per country)...
2018: PloS One
https://www.readbyqxmd.com/read/29704416/kleptomania-or-common-theft-diagnostic-and-judicial-difficulties
#11
REVIEW
Justyna Sipowicz, Ryszard Kujawski
First descriptions of kleptomania as a mental disorder date back to the nineteenth century. For the first time, kleptomania as an accompanying symptom rather than a formal diagnosis was included in the classification of psychiatric disorders of the American Psychiatric Association DSM-I in 1952. It was included in the International Classification of Diseases ICD-10 and classified under "habit and impulse disorders". Kleptomania is a serious disorder, as numerous thefts are impulsively carried out, carrying the risk of detection and consequently criminal liability...
February 28, 2018: Psychiatria Polska
https://www.readbyqxmd.com/read/29686740/world-digestive-health-day-wdhd-poland-2017-inflammatory-bowel-diseases-challenges-and-hopes
#12
Wojciech Marlicz
No abstract text is available yet for this article.
2018: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29686436/methotrexate-treatment-for-rheumatoid-arthritis-in-poland-retrospective-analysis-of-patients-in-routine-clinical-practice
#13
Jerzy Świerkot, Bogdan Batko, Piotr Wiland, Mariusz Jędrzejewski, Marcin Stajszczyk
Objectives: The aim of this study was to evaluate methotrexate (MTX) treatment administered by Polish rheumatologists in everyday practice. Material and methods: The study was based on a retrospective analysis of a cohort of 1957 patients with rheumatoid arthritis (RA). It was conducted among 100 rheumatologists, each of whom received 20 questionnaires and completed them based on the data from their rheumatoid arthritis patients. Results: Methotrexate was taken by 91% of patients, and 80% of them continued the treatment either as a monotherapy (65%) or concomitantly with other disease-modifying anti-rheumatic drugs...
2018: Reumatologia
https://www.readbyqxmd.com/read/29684297/is-medical-marijuana-legalisation-possible-in-poland
#14
Dorota Rogowska-Szadkowska, Julia Strumiło, Sławomir Chlabicz
OBJECTIVES: In some countries of the world it is legal to use plant-based marijuana for therapeutic purposes. When we had learned that 7,000 petitioners (including doctors) signed the petition to enable access to marijuana for patients in the Czech Republic, we decided to examine the knowledge about marijuana's medical properties among Polish medical students. METHODS: Anonymous questionnaire study was conducted on a group of 181 of students of the last (sixth) year of medical school...
March 2018: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29682098/testing-for-nras-mutations-in-serous-borderline-ovarian-tumors-and-low-grade-serous-ovarian-carcinomas
#15
Pawel Sadlecki, Dariusz Grzanka, Marek Grabiec
The Idylla NRAS Mutation Test , performed on the Biocartis Idylla system, is an in vitro diagnostic tool for the qualitative assessment of 18 NRAS mutations in codons 12, 13, 59, 61, 117, and 146. Low-grade serous ovarian cancer (LGSC) represents less than 10% of all serous ovarian carcinomas. LGSCs are believed to arise from preexisting cystadenomas or serous borderline tumors (SBOTs) that eventually progress to an invasive carcinoma. The molecular analysis of cancer-causing mutations and the development of targeted biological therapies constitute a milestone in the diagnosis and therapy of ovarian malignancies...
2018: Disease Markers
https://www.readbyqxmd.com/read/29673989/persisting-inequalities-in-survival-patterns-of-childhood-neuroblastoma-in-southern-and-eastern-europe-and-the-effect-of-socio-economic-development-compared-with-those-of-the-us
#16
Paraskevi Panagopoulou, Marios K Georgakis, Margarita Baka, Maria Moschovi, Vassilios Papadakis, Sophia Polychronopoulou, Maria Kourti, Emmanuel Hatzipantelis, Eftichia Stiakaki, Helen Dana, Athanasios Tragiannidis, Evdoxia Bouka, Luis Antunes, Joana Bastos, Daniela Coza, Anna Demetriou, Domenic Agius, Sultan Eser, Raluca Gheorghiu, Mario Šekerija, Maciej Trojanowski, Tina Žagar, Anna Zborovskaya, Anton Ryzhov, Nick Dessypris, Daniel Morgenstern, Eleni Th Petridou
AIM: Neuroblastoma outcomes vary with disease characteristics, healthcare delivery and socio-economic indicators. We assessed survival patterns and prognostic factors for patients with neuroblastoma in 11 Southern and Eastern European (SEE) countries versus those in the US, including-for the first time-the Nationwide Registry for Childhood Hematological Malignancies and Solid Tumours (NARECHEM-ST)/Greece. METHODS: Overall survival (OS) was calculated in 13 collaborating SEE childhood cancer registries (1829 cases, ∼1990-2016) and Surveillance, Epidemiology, and End Results (SEER), US (3072 cases, 1990-2012); Kaplan-Meier curves were used along with multivariable Cox regression models assessing the effect of age, gender, primary tumour site, histology, Human Development Index (HDI) and place of residence (urban/rural) on survival...
April 16, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29669701/crizotinib-in-patients-with-advanced-inoperable-inflammatory-myofibroblastic-tumours-with-and-without-anaplastic-lymphoma-kinase-gene-alterations-european-organisation-for-research-and-treatment-of-cancer-90101-create-a-multicentre-single-drug-prospective-non
#17
Patrick Schöffski, Jozef Sufliarsky, Hans Gelderblom, Jean-Yves Blay, Sandra J Strauss, Silvia Stacchiotti, Piotr Rutkowski, Lars H Lindner, Michael G Leahy, Antoine Italiano, Nicolas Isambert, Maria Debiec-Rychter, Raf Sciot, Thomas Van Cann, Sandrine Marréaud, Axelle Nzokirantevye, Sandra Collette, Agnieszka Wozniak
BACKGROUND: An inflammatory myofibroblastic tumour (IMFT) is a rare mesenchymal neoplasm characterised by anaplastic lymphoma kinase (ALK) gene rearrangements. We assessed the activity and safety of crizotinib, a tyrosine kinase inhibitor, targeting ALK in patients with advanced IMFT either with or without ALK alterations. METHODS: We did a multicentre, biomarker-driven, single-drug, non-randomised, open-label, two-stage phase 2 trial (European Organisation for Research and Treatment of Cancer 90101 CREATE) at 13 study sites (five university hospitals and eight specialty clinics) in eight European countries (Belgium, France, Germany, Italy, Netherlands, Poland, Slovakia, and the UK)...
April 12, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29667378/alarming-results-of-nosocomial-infections-in-a-multicenter-program-of-surveillance-in-polish-intensive-care-units
#18
Michał Wałaszek, Anna Różańska, Małgorzata Bulanda, Jadwiga Wojkowska-Mach, Polish Society of Hospital Infections Team
INTRODUCTION: Nosocomial bloodstream infections (BSI) among patients in intensive care units (ICU) are the most common form of nosocomial infections and they are serious complications of the treatment process. The etiological factors of these infections and the proper antibiotic therapy can influence the effects of patient treatment. The aim of the study was to analyze the epidemiology, microbiology and antibiotic therapy of nosocomial BSI in Polish ICU patients. MATERIALS AND METHODS: The retrospective study covered patients hospitalized in seven ICUs for adults with a general profile, located in southern Poland...
2018: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/29667376/tick-paralysis
#19
Karol Borawski, Sławomir Pancewicz, Piotr Czupryna, Joanna Zajkowska, Anna Moniuszko-Malinowska
Tick paralysis is caused by neurotoxins secreted by adult female ticks, primarily in North America and on the east coast of Australia. Sporadic illness is also recorded in Europe and Africa. In the European countries, including Poland, there are 6 species of ticks capable of causing tick paralysis. The disease occurs in people of all ages, but is most commonly diagnosed in children under 8 years of age. Paralysis can take different forms - from rare isolated cranial nerve infections to quadriplegia and respiratory muscles paralysis...
2018: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/29667146/cost-effectiveness-analysis-of-crohn-s-disease-treatment-with-vedolizumab-and-ustekinumab-after-failure-of-tumor-necrosis-factor-%C3%AE-antagonist
#20
Przemysław Holko, Paweł Kawalec, Andrzej Pilc
OBJECTIVE: The aim was to evaluate the cost-effectiveness of Crohn's disease (CD) treatment with vedolizumab and ustekinumab after failure of therapy with tumor necrosis factor-α antagonists (anti-TNFs). METHODS: The Markov model incorporated the lifetime horizon, synthesis-based estimates of biologics' efficacy in relation to anti-TNF exposure, and administration of biologics reflecting clinical practice (e.g., sequence of biologics, retreatment, 12-month treatment)...
April 17, 2018: PharmacoEconomics
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