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https://www.readbyqxmd.com/read/28214133/dynamic-hyperinflation-in-patients-with-asthma-and-exercise-induced-bronchoconstriction
#1
Olga Mediano, Raquel Casitas, Carlos Villasante, Elisabet Martínez-Cerón, Raúl Galera, Ester Zamarrón, Francisco García-Río
BACKGROUND: Little is known about the behavior of operative lung volumes during exercise in patients with asthma and exercise-induced bronchoconstriction (EIB). OBJECTIVES: To compare the presence of dynamic hyperinflation (DH) in patients with mild asthma with and without EIB and in healthy individuals and to relate the changes in end-expiratory lung volume (EELV) with postexercise airflow reduction. METHODS: A total of 122 consecutive stable patients (>12 years of age) with mild asthma and 38 controls were studied...
February 14, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28212451/relationship-between-pre-anesthetic-and-intra-anesthetic-airway-resistance-in-patients-undergoing-general-anesthesia-a-prospective-observational-study
#2
Takamitsu Ikeda, Kanji Uchida, Yasuhiro Yamauchi, Takahide Nagase, Koji Oba, Yoshitsugu Yamada
Surgery patients in Japan undergo routine spirometry testing prior to general anesthesia. The use of a flow sensor during general anesthesia has recently become common. However, it is not certain whether the information derived from flow-volume curves is being adequately used for mechanical ventilation management during general anesthesia. So far, there have been no attempts to calculate airway resistance using flow-volume curves. Therefore, we performed a prospective, observational study to investigate the relationship between pre-anesthetic and intra-anesthetic airway resistance in patients scheduled for surgery under general anesthesia...
2017: PloS One
https://www.readbyqxmd.com/read/28210495/reproducibility-of-pulmonary-blood-flow-measurements-by-phase-contrast-mri-using-different-1-5-t-mr-scanners-at-two-institutions
#3
Rin Iraha, Nanae Tsuchiya, Tsuneo Yamashiro, Tae Iwasawa, Sadayuki Murayama
BACKGROUND: Magnetic resonance imaging (MRI) can be beneficial for diagnosis of disease by offering quantitative information. However, reproducibility can be a major problem when there is a numerical threshold in multi-institution, multi-vendor situations. PURPOSE: To measure pulmonary blood flow with phase-contrast (PC) imaging using two different MR scanners (1.5 T) at different institutions in the same participants and to examine the reproducibility of the measurements...
January 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28209433/surface-runoff-and-subsurface-tile-drain-losses-of-neonicotinoids-and-companion-herbicides-at-edge-of-field
#4
François Chrétien, Isabelle Giroux, Georges Thériault, Patrick Gagnon, Julie Corriveau
With their application as seed coatings, the use of neonicotinoid insecticides increased dramatically during the last decade. They are now frequently detected in aquatic ecosystems at concentrations susceptible to harm aquatic invertebrates at individual and population levels. This study intent was to document surface runoff and subsurface tile drain losses of two common neonicotinoids (thiamethoxam and clothianidin) compared to those of companion herbicides (atrazine, glyphosate, S-metolachlor and mesotrione) at the edge of a 22...
February 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28190974/avoiding-misdiagnosis-in-patients-with-dyspnea-and-wheezing-a-case-report-illustrating-the-clinical-implications-of-fixation-error
#5
Fabiano Di Marco, Giuseppe Francesco Sferrazza Papa, Dejan Radovanovic, Pierachille Santus
BACKGROUND: Bronchial asthma is a heterogeneous respiratory condition which can be mimicked by a wide range of pathologies including upper airways stenosis. The accurate diagnosis of asthma, as with other conditions, may be influenced by fixation errors, which are common in medicine and occur when a physician concentrates on only one element of a clinical case without considering other relevant aspects. Here we report a challenging case characterized by the contemporaneous presence of a common disease, asthma, together with a rare respiratory disease, idiopathic tracheal stenosis...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/28188705/design-construction-and-optimization-of-a-novel-modular-and-scalable-incubation-chamber-for-continuous-viral-inactivation
#6
Raquel Orozco, Linus Amarikwa, Stephanie Parker, Scott Godfrey, Lindsay Hernandez, Chinenye Wachuku, Ben Mai, Brian Song, Shashidhar Hoskatti, Jinkeng Asong, Marcus Fiadeiro, Parviz Shamlou, Cameron Bardliving, Jon Coffman
We designed, built or 3D printed, and screened tubular reactors that minimize axial dispersion to serve as incubation chambers for continuous virus inactivation of biological products. Empirical residence time distribution data were used to derive each tubular design's volume equivalent to a theoretical plate (VETP) values at a various process flow rates. One design, the Jig In a Box (JIB), yielded the lowest VETP, indicating optimal radial mixing and minimal axial dispersion. A minimum residence time (MRT) approach was employed, where the MRT is the minimum time the product spends in the tubular reactor...
February 11, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28182566/measurement-of-tidal-breathing-flows-in-infants-using-impedance-pneumography
#7
Leo Pekka Malmberg, Ville-Pekka Seppä, Anne Kotaniemi-Syrjänen, Kristiina Malmström, Merja Kajosaari, Anna S Pelkonen, Jari Viik, Mika J Mäkelä
Tidal breathing flow volume (TBFV) profiles have been used to characterise altered lung function. Impedance pneumography (IP) is a novel option for assessing TBFV curves noninvasively. The aim of this study was to extend the application of IP for infants and to estimate the agreement between IP and direct pneumotachograph (PNT) measurements in assessing tidal airflow and flow-derived indices.Tidal flow profiles were recorded for 1 min simultaneously with PNT and uncalibrated IP at baseline in 44 symptomatic infants, and after methacholine-induced bronchoconstriction in a subgroup (n=20)...
December 19, 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28159689/investigation-of-the-confounding-effects-of-vasculature-and-metabolism-on-computational-anatomy-studies
#8
C L Tardif, C J Steele, L Lampe, P-L Bazin, P Ragert, A Villringer, C J Gauthier
Computational anatomy studies typically use T1-weighted magnetic resonance imaging contrast to look at local differences in cortical thickness or grey matter volume across time or subjects. This type of analysis is a powerful and non-invasive tool to probe anatomical changes associated with neurodevelopment, aging, disease or experience-induced plasticity. However, these comparisons could suffer from biases arising from vascular and metabolic subject- or time-dependent differences. Differences in blood flow and volume could be caused by vasodilation or differences in vascular density, and result in a larger signal contribution of the blood compartment within grey matter voxels...
February 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/28144465/incidence-rate-of-post-intubation-tracheal-stenosis-in-patients-admitted-to-five-intensive-care-units-in-iran
#9
Roya Farzanegan, Behrooz Farzanegan, Mahdi Zangi, Majid Golestani Eraghi, Shahram Noorbakhsh, Neda Doozandeh Tabarestani, Mohammad Behgam Shadmehr
BACKGROUND: Tracheal stenosis is one of the worst complications associated with endotracheal intubation and it is the most common reason for reconstructive airway surgeries. Due to various local risk factors, the incidence rate of tracheal stenosis may vary in different countries. In order to estimate the incidence rate of post-intubation tracheal stenosis (PITS) in patients admitted to an intensive care unit (ICU), a follow-up study was planned. As there was no similar methodological model in the literature, a feasibility step was also designed to examine the whole project and to enhance the follow-up rate...
September 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28123969/real-time-magnetic-resonance-imaging-of-deep-venous-flow-during-muscular-exercise-preliminary-experience
#10
Arun Antony Joseph, Klaus-Dietmar Merboldt, Dirk Voit, Johannes Dahm, Jens Frahm
BACKGROUND: The accurate assessment of peripheral venous flow is important for the early diagnosis and treatment of disorders such as deep-vein thrombosis (DVT) which is a major cause of post-thrombotic syndrome or even death due to pulmonary embolism. The aim of this work is to quantitatively determine blood flow in deep veins during rest and muscular exercise using a novel real-time magnetic resonance imaging (MRI) method for velocity-encoded phase-contrast (PC) MRI at high spatiotemporal resolution...
December 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28116606/concentrations-of-select-dissolved-trace-elements-and-anthropogenic-organic-compounds-in-the-mississippi-river-and-major-tributaries-during-the-summer-of-2012-and-2013
#11
Derek D Bussan, Clifford A Ochs, Colin R Jackson, Tarun Anumol, Shane A Snyder, James V Cizdziel
The Mississippi River drainage basin includes the Illinois, Missouri, Ohio, Tennessee, and Arkansas rivers. These rivers drain areas with different physiography, population centers, and land use, with each contributing a different suites of metals and wastewater contaminants that can affect water quality. In July 2012, we determined 18 elements (Be, Rb, Sr, Cd, Cs, Ba, Tl, Pb, Mg, Al, V, Cr, Mn, Fe, Co, Ni, Cu, Zn) and chlorophyll-a (Chl-a) in the five major tributaries and in the Upper Mississippi River. The following summer, we determined both trace elements and 25 trace organic compounds at 10 sites in a longitudinal study of the main stem of the Mississippi River from Grafton, Illinois to Natchez, Mississippi...
February 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28109009/using-flow-characteristics-in-three-dimensional-power-doppler-ultrasound-imaging-to-predict-complete-responses-in-patients-undergoing-neoadjuvant-chemotherapy
#12
Wei-Chung Shia, Yu-Len Huang, Hwa-Koon Wu, Dar-Ren Chen
OBJECTIVES: Strategies are needed for the identification of a poor response to treatment and determination of appropriate chemotherapy strategies for patients in the early stages of neoadjuvant chemotherapy for breast cancer. We hypothesize that power Doppler ultrasound imaging can provide useful information on predicting response to neoadjuvant chemotherapy. METHODS: The solid directional flow of vessels in breast tumors was used as a marker of pathologic complete responses (pCR) in patients undergoing neoadjuvant chemotherapy...
January 21, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28087074/quantifying-loading-toxic-concentrations-and-systemic-persistence-of-chloride-in-a-contemporary-mixed-land-use-watershed-using-an-experimental-watershed-approach
#13
J A Hubbart, E Kellner, L W Hooper, S Zeiger
A nested-scale experimental watershed study was implemented to quantify loading and persistence of chloride in an urbanizing, mixed-land-use watershed. A Midwest USA (Missouri) watershed was partitioned into five sub-basins with contrasting dominant land use. Streamwater was tested for chloride concentration four days per week from October 2009 through May 2014 at each site. Monitoring sites included co-located gauging and climate stations recording variables at 30-minute intervals. Results indicate significant (p<0...
January 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28060545/safety-and-immunogenicity-of-adenovirus-35-tb-vaccine-candidate-in-adults-with-active-or-previous-tb-a-randomized-trial
#14
Richard N van Zyl-Smit, Aliasgar Esmail, Mary E Bateman, Rodney Dawson, Jonathan Goldin, Eva van Rikxoort, Macaya Douoguih, Maria Grazia Pau, Jerald C Sadoff, J Bruce McClain, Margaret Ann Snowden, Jacqueline Benko, David A Hokey, Kathryn Tucker Rutkowski, Andrew Graves, Barbara Shepherd, Sadritdin Ishmukhamedov, Benjamin M N Kagina, Brian Abel, Willem A Hanekom, Thomas J Scriba, Eric D Bateman
RATIONALE: Administration of tuberculosis vaccines in participants with previous or current pulmonary tuberculosis may have the potential for causing harmful post-vaccination immunological (Koch-type) reactions. OBJECTIVES: To assess the safety and immunogenicity of three dose levels of the AERAS-402 live, replication-deficient adenovirus 35-vectored tuberculosis candidate vaccine, containing three mycobacterial antigens, in individuals with current or previous pulmonary tuberculosis...
January 6, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28047708/th-cd-207a-05-lung-surface-deformation-vector-fields-prediction-by-monitoring-respiratory-surrogate-signals
#15
J Nasehi Tehrani, A McEwan, J Wang
PURPOSE: In this study, we developed and evaluated a method for predicting lung surface deformation vector fields (SDVFs) based on surrogate signals such as chest and abdomen motion at selected locations and spirometry measurements. METHODS: A Patient-specific 3D triangular surface mesh of the lung region at end-expiration (EE) phase was obtained by threshold-based segmentation method. For each patient, a spirometer recorded the flow volume changes of the lungs; and 192 selected points at a regular spacing of 2cm X 2cm matrix points over a total area of 34cm X 24cm on the surface of chest and abdomen was used to detect chest wall motions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28040707/stridor-secondary-to-a-subglottic-neuroendocrine-tumour
#16
Daniel W Scholfield, S Virk Jagdeep, Paul Stimpson
Large cell neuroendocrine carcinoma is a rare high-grade neuroendocrine neoplasm of the larynx, that exhibits particularly aggressive behaviour. We present a case of a 42-year-old patient with progressive dyspnoea and biphasic stridor, initially treated as asthma and resulting in delayed definitive management. Flow volume loops demonstrated narrowed inspiratory and expiratory flow volume loops. Subsequent CT neck and thorax indicated a mass arising from the subglottis and the patient proceeded to microlaryngoscopy and trans-oral CO2 laser debulking...
December 30, 2016: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28035226/temperament-and-stress-coping-styles-in-bronchial-asthma-patients
#17
Michał Panek, Piotr Kuna, Andrzej Witusik, Radosław Wujcik, Adam Antczak, Tadeusz Pietras
INTRODUCTION: Temperament, defined as the formal characteristics of behavior, is a personality trait which can influence the clinical presentation and course of bronchial asthma. It determines susceptibility to stress as well as stress coping styles. AIM: The aim of the study was to assess whether healthy subjects differ from bronchial asthma patients with regard to temperamental variables and stress coping styles, and whether these factors may also differentiate patients with severe asthma from those with the milder form...
December 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28026888/measurement-of-blood-flow-in-an-intracranial-artery-bypass-from-the-internal-maxillary-artery-by-intraoperative-duplex-sonography
#18
Zaitao Yu, Xiang'en Shi, Shams Raza Brohi, Hai Qian, Fangjun Liu, Yang Yang
This study explored the hemodynamic characteristics of a subcranial-intracranial bypass from the internal maxillary artery by measuring blood flow on intraoperative duplex sonography. The hemodynamic parameters of the internal maxillary artery (n = 20), radial artery (n = 20), internal maxillary artery-middle cerebral artery bypass (n = 42), and internal maxillary artery-posterior cerebral artery bypass (n = 9) were measured by intraoperative duplex sonography. There was no significant difference in the internal diameters of the internal maxillary and radial arteries (mean ± SD, 2...
December 27, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27999150/the-concave-shape-of-the-forced-expiratory-flow-volume-curve-in-3-seconds-is-a-practical-surrogate-of-fev1-fvc-for-the-diagnosis-of-airway-limitation-in-inadequate-spirometry
#19
Hao Li, Chunhong Liu, Yi Zhang, Wei Xiao
BACKGROUND: Spirometry is important for the differential diagnosis of dyspnea. However, some patients cannot exhale for ≥6 s to achieve the American Thoracic Society/European Respiratory Society criteria. The aim of this study was to demonstrate the reliability of a new parameter that quantifies the degree of concavity in the first 3 s to define airway limitation as a surrogate for the FEV1/FVC. METHODS: Four hundred spirometry test results were selected through complete random sampling...
December 20, 2016: Respiratory Care
https://www.readbyqxmd.com/read/27982272/cardiopulmonary-exercise-test-background-applicability-and-interpretation
#20
Artur Haddad Herdy, Luiz Eduardo Fonteles Ritt, Ricardo Stein, Claudio Gil Soares de Araújo, Mauricio Milani, Romeu Sérgio Meneghelo, Almir Sérgio Ferraz, Carlos Hossri, Antonio Eduardo Monteiro de Almeida, Miguel Morita Fernandes-Silva, Salvador Manoel Serra
Cardiopulmonary exercise test (CPET) has been gaining importance as a method of functional assessment in Brazil and worldwide. In its most frequent applications, CPET consists in applying a gradually increasing intensity exercise until exhaustion or until the appearance of limiting symptoms and/or signs. The following parameters are measured: ventilation; oxygen consumption (VO2); carbon dioxide production (VCO2); and the other variables of conventional exercise testing. In addition, in specific situations, pulse oximetry and flow-volume loops during and after exertion are measured...
November 2016: Arquivos Brasileiros de Cardiologia
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