Michaela Orlitová, Tom Verbelen, Anna E Frick, Arno Vanstapel, Dieter Van Beersel, Sofie Ordies, Jan Van Slambrouck, Janne Kaes, Jin Xin, Walter Coudyzer, Stijn E Verleden, Geert M Verleden, Bart M Vanaudenaerde, Dirk E Van Raemdonck, Robin Vos, Laurens J Ceulemans, Piet Claus, Arne P Neyrinck
Lung transplantation is a challenging procedure. Following the process of ischemia-reperfusion injury, the transplanted pulmonary graft might become severely damaged, resulting in primary graft dysfunction. Additionally, during the intra-operative window, the right ventricle is at risk of acute failure. The interaction of right ventricular function with lung injury, is however, poorly understood. We aimed to address this interaction in a translational porcine model of pulmonary ischemia-reperfusion injury. Advanced pulmonary and hemodynamic assessment was used, including right ventricular pressure-volume loop analysis...
September 19, 2023: American Journal of Physiology. Lung Cellular and Molecular Physiology