keyword
https://read.qxmd.com/read/38164499/fibrin-targeted-phase-shift-microbubbles-for-the-treatment-of-microvascular-obstruction
#21
JOURNAL ARTICLE
Soheb Anwar Mohammed, Muhammad Wahab Amjad, Maria F Acosta, Xucai Chen, Linda Lavery, Dillon Hanrahan, Evan C Unger, Emmanuelle J Meuillet, John J Pacella
Rationale: Microvascular obstruction (MVO) following percutaneous coronary intervention (PCI) is a common problem associated with adverse clinical outcomes. We are developing a novel treatment, termed sonoreperfusion (SRP), to restore microvascular patency. This entails using ultrasound-targeted microbubble cavitation (UTMC) of intravenously administered gas-filled lipid microbubbles (MBs) to dissolve obstructive microthrombi in the microvasculature. In our prior work, we used standard-sized lipid MBs. In the present study, to improve upon the efficiency and efficacy of SRP, we sought to determine the therapeutic efficacy of fibrin-targeted phase shift microbubbles (FTPSMBs) in achieving successful reperfusion of MVO...
2024: Nanotheranostics
https://read.qxmd.com/read/38161653/simulated-obstructive-respiratory-disease-dataset-over-increasing-positive-end-expiratory-pressure
#22
JOURNAL ARTICLE
Jaimey A Clifton, Ella F S Guy, Trudy Caljé-van der Klei, Jennifer L Knopp, J Geoffrey Chase
The breathing dataset presented is collected from 20 healthy individuals at the University of Canterbury using a device to simulate the pressure and flow profiles of obstructive pulmonary disease. Specifically, the expiratory non-linear resistance, which generates the characteristic expiratory pressure-flow loop lobe seen in obstructive disease. Ethical consent for the trial was granted by the University of Canterbury Human Research Ethics Committee (Ref: HREC 2022/26/LR). Data was collected using an open-source data collection device connected to a Fisher and Paykel Healthcare SleepStyle SPSCAA CPAP...
February 2024: Data in Brief
https://read.qxmd.com/read/38155132/the-role-of-hereditary-predisposition-polymorphic-markers-of-glutathione-s-transferase-catalase-endothelial-nitrogen-oxide-synthase-genes-and-some-adverse-environmental-factors-in-the-development-of-broncho-obstructive-pathology-in-children-living-in-radioactively
#23
JOURNAL ARTICLE
I Ye Kolpakov, V Yu Vdovenko, V M Zyhalo, V G Kondrashova, H M Chobotko, L A Raichuk, O S Leonovych
OBJECTIVE: summarizing the results of many years of research by the authors on the influence of gene polymorphisms encoding xenobiotic biotransformation enzymes (GSTТ1, GSTM1, GSTР1), antioxidant protection (С^262Т of the catalase gene), endothelial nitric oxide synthase (4a/4b VNTR polymorphism of the eNOS gene), and some environmental factors on the occurrence of broncho-obstructive disorders and the development of bronchial asthma in children, residents of radioactively contaminated areas...
December 2023: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://read.qxmd.com/read/38114147/-advantage-analysis-of-flow-through-cell-method-in-quality-evaluation-of-chinese-patent-medicine-a-case-study-of-danshen-tablets
#24
JOURNAL ARTICLE
Zhe Wu, Hong Yi, Chun Li, Qi-Ping Cui, Hong-Yu Liu, Feng-Qian Guo, Ding-Hua Xiang, Xiao-Qian Liu, Xiao-Li Sun
To explore the quality consistency evaluation method for multi-component traditional Chinese medicine and establish a dissolution evaluation method suitable for the characteristics of multi-component Chinese patent medicine, this study discussed the characteristics and advantages of the flow-through cell method in the dissolution evaluation of Chinese patent medicine by comparing the impact of the small cup method and the flow-through cell method on the dissolution behavior of water-soluble and lipid-soluble major active components of Danshen Tablets...
October 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/38068529/intraoperative-blood-flow-analysis-of-free-flaps-with-arteriovenous-loops-for-autologous-microsurgical-reconstruction
#25
JOURNAL ARTICLE
Alexander Geierlehner, Raymund E Horch, Ingo Ludolph, Werner Lang, Ulrich Rother, Alexander Meyer, Andreas Arkudas
BACKGROUND: Arteriovenous (AV) loops help to overcome absent or poor-quality recipient vessels in highly complex microvascular free flap reconstruction cases. There are no studies on blood flow and perfusion patterns. The purpose of this study was to evaluate and compare intraoperative hemodynamic characteristics of AV loops followed by free tissue transfer for thoracic wall and lower extremity reconstruction. METHODS: this prospective clinical study combined Transit-Time Flowmetry and microvascular Indocyanine Green Angiography for the assessment of blood flow volume, arterial vascular resistance and intrinsic transit time at the time of AV loop construction and on the day of free flap transfer...
December 2, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38031090/presence-of-variable-extrathoracic-airflow-limitation-in-patients-with-a-negative%C3%A2-methacholine-challenge-test
#26
JOURNAL ARTICLE
Zane Z Elfessi, Sarah Zavala, Israel Rubinstein
PURPOSE: Determine whether variable extrathoracic airflow limitation (VEAL) is observed in patients with negative methacholine challenge tests (MCT). METHODS: Electronic medical records of patients undergoing MCT at Jesse Brown VA Medical Center between January 2017 and December 2019 were reviewed. Only patients with negative MCT were selected. Pertinent demographic, clinical, and pulmonary function tests (PFT) and MCT data were abstracted from each record. Spirometric flow-volume loops recorded during each test were inspected by one co-author to determine the first inhaled methacholine concentration at which FEF50 /FIF50 was either > 1 or further increased if baseline FEF50 /FIF50 after nebulized saline (vehicle) already exceeded 1...
November 29, 2023: Allergy, Asthma, and Clinical Immunology
https://read.qxmd.com/read/38017501/using-intra-breath-oscillometry-in-obesity-hypoventilation-syndrome-to-detect-tidal-expiratory-flow-limitation-a-potential-marker-to-optimize-cpap-therapy
#27
JOURNAL ARTICLE
Szabolcs Baglyas, Luca Valkó, Vivien Móró, Eszter Podmaniczky, Dorottya Czövek, Gergely Makan, Zoltán Gingl, János Gál, Zoltán Hantos, András Lorx
BACKGROUND: Continuous positive airway pressure (CPAP) therapy has profound effects in obesity hypoventilation syndrome (OHS). Current therapy initiation focuses on upper airway patency rather than the assessment of altered respiratory mechanics due to increased extrapulmonary mechanical load. METHODS: We aimed to examine the viability of intra-breath oscillometry in optimizing CPAP therapy for OHS. We performed intra-breath oscillometry at 10 Hz in the sitting and supine positions, followed by measurements at increasing CPAP levels (none-5-10-15-20 cmH2 O) in awake OHS patients...
November 28, 2023: BMC Pulmonary Medicine
https://read.qxmd.com/read/38005588/research-on-an-active-hydrogen-maser-digital-circuit-control-system-based-on-fpga
#28
JOURNAL ARTICLE
Wangwang Hu, Tao Shuai, Yonghui Xie, Pengfei Chen, Yuxian Pei, Yang Zhao, Rui Wang
A hydrogen maser is a high-precision time measurement instrument with high frequency stability and low frequency drift, which is widely used in satellite navigation, ground time keeping, frequency measurement, and other fields. An active hydrogen maser (AHM) is better than the current space passive hydrogen maser (PHM) in orbit in terms of its frequency stability and drift rate, but it has the disadvantages of large volume and weight. To further reduce the volume and weight of the circuit, this paper demonstrates a digital circuit control system based on a field-programmable gate array (FPGA)...
November 15, 2023: Sensors
https://read.qxmd.com/read/37975489/lung-function-in-preterm-infants-at-3-months-corrected-age-after-neonatal-lc-pufa-supplementation
#29
JOURNAL ARTICLE
Kristina Wendel, Madelaine Eloranta Rossholt, Gunnthorunn Gunnarsdottir, Marlen Fossan Aas, Åsbjørn Schumacher Westvik, Are Hugo Pripp, Karin C Lødrup Carlsen, Drude Fugelseth, Tom Stiris, Sissel Jennifer Moltu
OBJECTIVE: To test the hypothesis that long-chain polyunsaturated fatty acid (LC-PUFA) supplementation improves lung function at 3 months corrected age (CA) compared with standard treatment in very preterm infants. We also aimed to investigate the association between bronchopulmonary dysplasia (BPD), longitudinal growth, and lung function at 3 months CA. METHODS: A secondary analysis from the ImNuT trial, in which 121 infants with gestational age <29 weeks were randomized to a daily supplement with arachidonic acid (ARA) and docosahexaenoic acid (DHA) (ARA:DHA group) or MCT-oil (control group) from birth up to 36 weeks postmenstrual age (PMA)...
November 17, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/37961972/is-flow-volume-loop-helpful-in-differentiating-between-unilateral-and-bilateral-vocal-cord-palsy
#30
JOURNAL ARTICLE
K C Shikha, Ragitha B Krishnan, Arjun Padmanabhan
No abstract text is available yet for this article.
2023: Lung India: Official Organ of Indian Chest Society
https://read.qxmd.com/read/37947885/functionalized-carbon-nanotube-polyaniline-composite-coating-for-on-line-microextraction-on-a-screw-coupled-with-high-performance-liquid-chromatography-to-determine-opium-alkaloids
#31
JOURNAL ARTICLE
Payam Osooli, Yadollah Yamini, Mahmoud Tabibpour, Negar Sabahi Moosavi
A novel and efficient on-line microextraction on a screw coupled with high-performance liquid chromatography with an ultraviolet-visible detector was developed to extract and determine trace quantities of five opium alkaloids. All detections of the analytes were achieved at 210 nm. The surface of the screw grooves was electrochemically coated with the carbon nanotubes-COOH/polyaniline composite. The surface characterization was assessed by Fourier transform infrared spectroscopy and field emission scanning electron microscopy...
November 10, 2023: Mikrochimica Acta
https://read.qxmd.com/read/37933990/development-of-simple-rapid-and-sensitive-methods-for-detection-of-hepatitis-c-virus-rna-from-whole-blood-using-reverse-transcription-loop-mediated-isothermal-amplification
#32
JOURNAL ARTICLE
Matthew D Pauly, Sabrina Weis-Torres, Tonya M Hayden, Lilia M Ganova-Raeva, Saleem Kamili
Hepatitis C virus (HCV) infection is an underdiagnosed global health problem. Diagnosis of current HCV infections typically requires testing for HCV RNA using high-complexity laboratory tests. Methods for the detection of HCV RNA that are simple, inexpensive, rapid, and compatible with use outside of a laboratory setting are very important in order to improve access to hepatitis C diagnostic testing and facilitate accelerated linkage to care. We developed and evaluated three simple workflows for extracting HCV RNA from small volumes of whole blood for use in a sensitive, pan-genotypic RT-LAMP assay...
November 7, 2023: Journal of Clinical Microbiology
https://read.qxmd.com/read/37923315/validation-of-a-multiscale-computational-model-using-a-mock-circulatory-loop-to-simulate-cardiogenic-shock
#33
JOURNAL ARTICLE
Christian Contarino, Francesco Chifari, Gavin A D'Souza, Luke H Herbertson
The objectives of this study are to characterize the hemodynamics of cardiogenic shock (CS) through a computational model validated using a mock circulatory loop (MCL) and to perform sensitivity analysis and uncertainty propagation studies after the American Society of Mechanical Engineers (ASME) Validation and Verification (V&V) guidelines. The uncertainties in cardiac cycle time (T0), total resistance (), and total volume (Vs) were quantified in the MCL and propagated in the computational model. Both models were used to quantify the pressure in the left atrium, aorta (Ao), and left ventricle (LV), along with the flow through the aortic valve, reaching a good agreement...
November 2, 2023: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/37916135/spirometry-reference-equations-including-existing-and-novel-parameters
#34
JOURNAL ARTICLE
Douglas Clark Johnson, Bradford Gardner Johnson
INTRODUCTION: Spirometry is an essential component of pulmonary function testing, with interpretation dependent upon comparing results to normal. Reference equations for mean and lower limit of normal (LLN) are available for usual parameters, including forced vital capacity (FVC), forced expiratory volume in the first second of an FVC maneuver (FEV1), and FEV1/FVC. However, standard parameters do not fully characterize the flow-volume loop and equations are unavailable for the upper limit of normal (ULN)...
2023: Open Respiratory Medicine Journal
https://read.qxmd.com/read/37881847/static-respiratory-mechanics-are-unaltered-in-males-and-females-with-obesity
#35
JOURNAL ARTICLE
Jonathon L Stickford, Dharini M Bhammar, Bryce N Balmain, Tony G Babb
We tested the hypothesis that independent of the obesity-related shift in lung volume subdivisions, obesity would not reduce the interrelationships of expiratory flow, lung volume, and static lung elastic recoil pressure in males and females. Simultaneous measurements of expiratory flow, volume, and transpulmonary pressure were continuously recorded while flow-volume loops of varying expiratory efforts were performed in a pressure-corrected, volume-displacement body plethysmograph in males and females with obesity...
October 26, 2023: Journal of Applied Physiology
https://read.qxmd.com/read/37844674/longitudinal-analysis-left-ventricular-chamber-responses-under-durable-lvad-support
#36
JOURNAL ARTICLE
Aaron Gunawan, Desiree Robson, Rohan J Krishnaswamy, Anju Ramanayake, Katherine Kearney, Kavitha Muthiah, Pankaj Jain, Audrey Adji, Christopher S Hayward
BACKGROUND: Left ventricular assist device (LVAD) support offers remodeling potential in some patients. Our goal was to use noninvasively derived pressure-volume (PV) loops to understand the effect of demographic and device variables on serial changes in cardiac function under pump support. METHODS: Thirty-two consecutive Medtronic HeartWare Ventricular Assist Device (HVAD) patients (mean 55.9 ± 12.3 years, 81.3% male) were prospectively recruited...
October 14, 2023: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/37821579/artificial-neural-network-identification-of-exercise-expiratory-flow-limitation-in-adults
#37
JOURNAL ARTICLE
Hans Christian Haverkamp, Peter Luu, Thomas W DeCato, Gregory Petrics
Identification of ventilatory constraint is a key objective of clinical exercise testing. Expiratory flow-limitation (EFL) is a well-known type of ventilatory constraint. However, EFL is difficult to measure, and commercial metabolic carts do not readily identify or quantify EFL. Deep machine learning might provide a new approach for identifying EFL. The objective of this study was to determine if a convolutional neural network (CNN) could accurately identify EFL during exercise in adults in whom baseline airway function varied from normal to mildly obstructed...
October 11, 2023: Scientific Reports
https://read.qxmd.com/read/37808064/computational-fluid-dynamics-simulate-optimal-design-of-segmental-arteries-reattachment-influence-of-blood-flow-stagnation
#38
JOURNAL ARTICLE
Yuki Ikeno, Yoshishige Takayama, Michael L Williams, Yujiro Kawaniashi, Paul Jansz
OBJECTIVES: This study aimed to simulate blood flow stagnation using computational fluid dynamics and to clarify the optimal design of segmental artery reattachment for thoracoabdominal aortic repair. METHODS: Blood flow stagnation, defined by low-velocity volume or area of the segmental artery, was simulated by a 3-dimensional model emulating the systolic phase. Four groups were evaluated: direct anastomosis, graft interposition, loop-graft, and end graft. Based on contemporary clinical studies, direct anastomosis can provide a superior patency rate than other reattachment methods...
September 2023: JTCVS open
https://read.qxmd.com/read/37803309/bronchial-oncocytic-carcinoma-in-an-adult-a-case-report-and-literature-review
#39
JOURNAL ARTICLE
Yi-Fan Shen, Cheng-Long Wang, Zhi-Gang Chu, You-De Cao, Yan Luo, Yang-Li Zhang, Yi-Jia Cao
BACKGROUND: Lung salivary-type tumors originating from bronchial submucosal glands are rare, only four types of salivary gland-type tumors are listed in 2015 WHO classification of lung tumors. Here, we report a rare case of oncocytic carcinoma (OC) in the right main bronchus. CASE PRESENTATION: A 34-year-old man presented to our hospital with a two-month history of recurrent hemoptysis and with one month of inspiratory dyspnea. Pulmonary function tests showed mild restrictive ventilatory dysfunction and severe diffusion dysfunction...
October 6, 2023: BMC Pulmonary Medicine
https://read.qxmd.com/read/37724349/the-hemodynamic-interplay-between-pulmonary-ischemia-reperfusion-injury-and-right-ventricular-function-in-lung-transplantation-a-translational-porcine-model
#40
JOURNAL ARTICLE
Michaela Orlitová, Tom Verbelen, Anna E Frick, Arno Vanstapel, Dieter Van Beersel, Sofie Ordies, Jan Van Slambrouck, Janne Kaes, Jin Xin, Walter Coudyzer, Stijn E Verleden, Geert M Verleden, Bart M Vanaudenaerde, Dirk E Van Raemdonck, Robin Vos, Laurens J Ceulemans, Piet Claus, Arne P Neyrinck
Lung transplantation is a challenging procedure. Following the process of ischemia-reperfusion injury, the transplanted pulmonary graft might become severely damaged, resulting in primary graft dysfunction. Additionally, during the intra-operative window, the right ventricle is at risk of acute failure. The interaction of right ventricular function with lung injury, is however, poorly understood. We aimed to address this interaction in a translational porcine model of pulmonary ischemia-reperfusion injury. Advanced pulmonary and hemodynamic assessment was used, including right ventricular pressure-volume loop analysis...
September 19, 2023: American Journal of Physiology. Lung Cellular and Molecular Physiology
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