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https://www.readbyqxmd.com/read/28402103/patient-derived-airway-secretion-dissociation-technique-to-isolate-and-concentrate-immune-cells-using-closed-loop-inertial-microfluidics
#1
Hyunryul Ryu, Kyungyong Choi, Yanyan Qu, Taehong Kwon, Janet S Lee, Jongyoon Han
Assessment of airway secretion cells, both for research and clinical purposes, is a highly desired goal in patients with acute and chronic pulmonary diseases. However, lack of proper cell isolation and enrichment techniques hinder downstream evaluation and characterization of cells found in airway secretions. Here, we demonstrate a novel enrichment method to capture immune-related cells from clinical airway secretions using closed-loop separation of spiral inertial microfluidics (C-sep). By recirculating the output focusing stream back to the input reservoir and running continuously with a high flow processing rate, one can achieve optimal concentration, recovery and purity of airway immune cells from a large volume of diluent, which was not readily possible in the single-pass operation...
April 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28390491/ferric-reducing-antioxidant-potential-frap-of-antioxidants-using-reaction-flow-chromatography
#2
A Jones, S Pravadali-Cekic, G R Dennis, R Bashir, P J Mahon, R A Shalliker
High performance liquid chromatography coupled with post column derivatisation (HPLC-PCD) may be used to profile the antioxidant content of a sample. There are, however, drawbacks in the use of HPLC-PCD setups; namely the high volume reaction coils that are typically used lowering the observed separation efficiency. Reaction flow chromatography has the ability to overcome these inefficiencies by using a more efficient mixing technique inside the outlet fitting itself, post column reaction loops can be removed with resulting improvement in signal to noise response, plus the separation efficiency is maintained...
May 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28372840/restriction-capillaries-as-an-innovative-mixing-unit-for-intermediate-mobile-phase-exchange-in-multidimensional-analysis
#3
Glenn Loos, Konstantin Shoykhet, Monika Dittmann, Deirdre Cabooter
A novel mixing unit is proposed for the serial coupling of orthogonal columns to analyze polar and non-polar compounds in a single run. The principle relies on the isolation of unretained peaks eluting from a first dimension column in a sample loop, before directing them to a second column for separation. Since the mobile phases employed in highly orthogonal separations are not directly compatible, a mixing unit is required to alter the mobile phase composition before executing the second dimension separation...
March 19, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28368344/the-combination-of-micro-diaphragm-pumps-and-flow-sensors-for-single-stroke-based-liquid-flow-control
#4
Christoph Jenke, Jaume Pallejà Rubio, Sebastian Kibler, Johannes Häfner, Martin Richter, Christoph Kutter
With the combination of micropumps and flow sensors, highly accurate and secure closed-loop controlled micro dosing systems for liquids are possible. Implementing a single stroke based control mode with piezoelectrically driven micro diaphragm pumps can provide a solution for dosing of volumes down to nanoliters or variable average flow rates in the range of nL/min to μL/min. However, sensor technologies feature a yet undetermined accuracy for measuring highly pulsatile micropump flow. Two miniaturizable in-line sensor types providing electrical readout-differential pressure based flow sensors and thermal calorimetric flow sensors-are evaluated for their suitability of combining them with mircopumps...
April 3, 2017: Sensors
https://www.readbyqxmd.com/read/28298663/lean-flow-optimizing-cardiopulmonary-bypass-equipment-and-flow-for-obese-patients-a-technique-article
#5
Joshua M Blessing, Jeffrey B Riley
The goal of this chart review was to investigate the use of down-sized cardiopulmonary bypass (CPB) circuits for obese patients. The effects of transitioning from larger to smaller oxygenators, reservoirs, and arteriovenous tubing loops were evaluated through a retrospective review of 2,816 adult non-congenital procedure perfusion records. This technique report and case series is a continuation of our original prescriptive CPB circuit quality improvement project. An algorithm was derived to adjust body surface area (BSA) to lower body mass index (BMI) to provide down-sized extracorporeal circuit components capable of meeting the metabolic needs of the patient...
March 2017: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/28272309/determination-of-the-clean-air-delivery-rate-cadr-of-photocatalytic-oxidation-pco-purifiers-for-indoor-air-pollutants-using-a-closed-loop-reactor-part-ii-experimental-results
#6
Valérie Héquet, Frédéric Batault, Cécile Raillard, Frédéric Thévenet, Laurence Le Coq, Éric Dumont
The performances of a laboratory PhotoCatalytic Oxidation (PCO) device were determined using a recirculation closed-loop pilot reactor. The closed-loop system was modeled by associating equations related to two ideal reactors: a perfectly mixed reservoir with a volume of VR = 0.42 m³ and a plug flow system corresponding to the PCO device with a volume of VP = 5.6 × 10(-3) m³. The PCO device was composed of a pleated photocatalytic filter (1100 cm²) and two 18-W UVA fluorescent tubes. The Clean Air Delivery Rate (CADR) of the apparatus was measured under different operating conditions...
March 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28228405/inhibition-of-romk-blocks-macula-densa-tubuloglomerular-feedback-yet-causes-renal-vasoconstriction-in-anesthetized-rats
#7
Magali Araujo, William J Welch, Xiaoyan Zhou, Kathleen Sullivan, Shawn Walsh, Alexander Pasternak, Christopher S Wilcox
The Na+/K+/2Cl- cotransporter (NKCC2) on the loop of Henle is the site of action of furosemide. Since outer medullary potassium channel (ROMK) inhibitors prevent reabsorption by NKCC2, we tested the hypothesis that ROMK inhibition with a novel, selective ROMK inhibitor (Compound C) blocks tubuloglomerular feedback (TGF) and reduces vascular resistance. Loop perfusion of either ROMK inhibitor or furosemide caused dose-dependent blunting of TGF, but the response to furosemide was 10-fold more sensitive (IC50= 10-6M for furosemide and IC50=10-5M for Compound C)...
February 22, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28214133/dynamic-hyperinflation-in-patients-with-asthma-and-exercise-induced-bronchoconstriction
#8
Olga Mediano, Raquel Casitas, Carlos Villasante, Elisabet Martínez-Cerón, Raúl Galera, Ester Zamarrón, Francisco García-Río
BACKGROUND: Little is known about the behavior of operative lung volumes during exercise in patients with asthma and exercise-induced bronchoconstriction (EIB). OBJECTIVE: To compare the presence of dynamic hyperinflation (DH) in patients with mild asthma with and without EIB and in healthy individuals and to relate the changes in end-expiratory lung volume (EELV) with postexercise airflow reduction. METHODS: A total of 122 consecutive stable patients (>12 years of age) with mild asthma and 38 controls were studied...
April 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28202552/airway-dynamics-in-copd-patients-by-within-breath-impedance-tracking-effects-of-continuous-positive-airway-pressure
#9
András Lorx, Dorottya Czövek, Zoltán Gingl, Gergely Makan, Bence Radics, Dóra Bartusek, Szabolcs Szigeti, János Gál, György Losonczy, Peter D Sly, Zoltán Hantos
Tracking of the within-breath changes of respiratory mechanics using the forced oscillation technique may provide outcomes that characterise the dynamic behaviour of the airways during normal breathing.We measured respiratory resistance (Rrs) and reactance (Xrs) at 8 Hz in 55 chronic obstructive pulmonary disease (COPD) patients and 20 healthy controls, and evaluated Rrs and Xrs as functions of gas flow (V') and volume (V) during normal breathing cycles. In 12 COPD patients, additional measurements were made at continuous positive airway pressure (CPAP) levels of 4, 8, 14 and 20 hPa...
February 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28149069/impact-of-yoga-in-a-case-of-vocal-cord-dysfunction-with-dysautonomia
#10
Rozina Wadhwania
A 23-year-old female with a past medical history of gastroesophageal reflux disease presented with shortness of breath induced by exercise and certain odors. She reported the symptoms of autonomic dysfunction including fatigue, chest pain, lightheadedness, headaches, numbness/tingling in the arms and legs, and exercise intolerance. Vital signs were significant for orthostatic intolerance. Volume flow loop in the pulmonary function tests showed a flattening of the inspiratory portion characteristic of vocal cord dysfunction...
January 2017: International Journal of Yoga
https://www.readbyqxmd.com/read/28144465/incidence-rate-of-post-intubation-tracheal-stenosis-in-patients-admitted-to-five-intensive-care-units-in-iran
#11
Roya Farzanegan, Behrooz Farzanegan, Mahdi Zangi, Majid Golestani Eraghi, Shahram Noorbakhsh, Neda Doozandeh Tabarestani, Mohammad Behgam Shadmehr
BACKGROUND: Tracheal stenosis is one of the worst complications associated with endotracheal intubation and it is the most common reason for reconstructive airway surgeries. Due to various local risk factors, the incidence rate of tracheal stenosis may vary in different countries. In order to estimate the incidence rate of post-intubation tracheal stenosis (PITS) in patients admitted to an intensive care unit (ICU), a follow-up study was planned. As there was no similar methodological model in the literature, a feasibility step was also designed to examine the whole project and to enhance the follow-up rate...
September 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28105847/compact-ultrahigh-pressure-nanoflow-capillary-liquid-chromatograph
#12
Xiaofeng Zhao, Xiaofeng Xie, Sonika Sharma, Luke T Tolley, Alex Plistil, Hal E Barnett, Martin P Brisbin, Adam C Swensen, John C Price, Paul B Farnsworth, H Dennis Tolley, Stanley D Stearns, Milton L Lee
A compact ultrahigh-pressure nanoflow liquid chromatograph (LC) was developed with the purpose in mind of creating a portable system that could be easily moved to various testing locations or placed in close proximity to other instruments for optimal coupling, such as with mass spectrometry (MS). The system utilized innovative nanoflow pumps integrated with a very low volume stop-flow injector and mixing tee. The system weighed only 5.9 kg (13 lbs) or 4.5 kg (10 lbs) without a controller and could hold up to 1100 bar (16000 psi) of pressure...
January 3, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28047932/tu-h-campus-iep3-02-neurovascular-4d-parametric-imaging-using-co-registration-of-biplane-dsa-sequences-with-3d-vascular-geometry-obtained-from-cone-beam-ct
#13
A Balasubramoniam, D Bednarek, S Rudin, C Ionita
PURPOSE: To create 4D parametric images using biplane Digital Subtraction Angiography (DSA) sequences co-registered with the 3D vascular geometry obtained from Cone Beam-CT (CBCT). METHODS: We investigated a method to derive multiple 4D Parametric Imaging (PI) maps using only one CBCT acquisition. During this procedure a 3D-DSA geometry is stored and used subsequently for all 4D images. Each time a biplane DSA is acquired, we calculate 2D parametric maps of Bolus Arrival Time (BAT), Mean Transit Time (MTT) and Time to Peak (TTP)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043677/pressure-volume-loop-derived-cardiac-indices-during-dobutamine-stress-a-step-towards-understanding-limitations-in-cardiac-output-in-children-with-hypoplastic-left-heart-syndrome
#14
James Wong, Kuberan Pushparajah, Adelaide de Vecchi, Bram Ruijsink, Gerald F Greil, Tarique Hussain, Reza Razavi
BACKGROUND: Children with a single systemic right ventricle, such as in hypoplastic left heart syndrome (HLHS), frequently experience reduced exercise capacity. Elucidating the causes could help with optimising treatment strategies. METHODS: Prospective data from 10 consecutive symptomatic patients with HLHS undergoing clinical cardiac magnetic resonance with catheterisation (XMR) were analysed. Mean age 8.6years (range 3.5-11.6years), mean time since Fontan completion 5...
March 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28040707/stridor-secondary-to-a-subglottic-neuroendocrine-tumour
#15
D W Scholfield, J S Virk, P Stimpson
No abstract text is available yet for this article.
March 1, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28029367/on-the-feasibility-to-conduct-gradient-liquid-chromatography-separations-in-narrow-bore-columns-at-pressures-up-to-2000bar
#16
Ruben De Pauw, Tim Swier, Bart Degreef, Gert Desmet, Ken Broeckhoven
The limits in operating pressures are extended for narrow-bore columns in gradient elution up to 2000bar. As the required pumps for these pressures are incompatible with common chromatographic solvents and are not suitable to apply a mobile phase composition gradient, a mobile phase delivery and injection system is described and experimentally validated which allows to use any possible chromatographic solvent in isocratic and gradient elution. The mobile phase delivery and injection system also allows to perform multiple separations without the need to depressurize the column...
October 6, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28026740/comparative-hemodynamic-effects-of-contemporary-percutaneous-mechanical-circulatory-support-devices-in-a-porcine-model-of-acute-myocardial-infarction
#17
Brian R Weil, Filip Konecny, Gen Suzuki, Vijay Iyer, John M Canty
OBJECTIVES: The aim of this study was to directly compare the hemodynamic effects of 2 contemporary percutaneous mechanical circulatory support devices in a porcine model of acute myocardial infarction. BACKGROUND: Percutaneous support devices offer the ability to unload the ischemic left ventricle, but the comparative hemodynamic effects of contemporary platforms are unclear. METHODS: Yorkshire swine (mean weight 76 ± 2 kg; n = 7) were instrumented with a left ventricular (LV) pressure-volume (PV) catheter and subjected to a 2-h coronary occlusion...
November 28, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27987598/role-of-vessel-to-prosthesis-size-mismatch-in-venous-valve-performance
#18
Wei-Hsin Tien, Xuefeng Zhao, Henry Y Chen, Zachary C Berwick, Joshua F Krieger, Sean Chambers, Dana Dabiri, Ghassan S Kassab
BACKGROUND: Efforts to treat chronic venous insufficiency have focused on the development of prosthetic venous valves. The role of prosthetic valve-to-vessel size matching has not been determined. The purpose of this investigation was to assess the effect of size mismatching on venous valve function and to establish a mismatch limit that affects valve hemodynamic performance and venous wall stress to improve future valve designs and implants. METHODS: Flow dynamics of prosthetic venous valves were studied in vitro using a pulse duplicator flow loop...
January 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/27982272/cardiopulmonary-exercise-test-background-applicability-and-interpretation
#19
Artur Haddad Herdy, Luiz Eduardo Fonteles Ritt, Ricardo Stein, Claudio Gil Soares de Araújo, Mauricio Milani, Romeu Sérgio Meneghelo, Almir Sérgio Ferraz, Carlos Hossri, Antonio Eduardo Monteiro de Almeida, Miguel Morita Fernandes-Silva, Salvador Manoel Serra
Cardiopulmonary exercise test (CPET) has been gaining importance as a method of functional assessment in Brazil and worldwide. In its most frequent applications, CPET consists in applying a gradually increasing intensity exercise until exhaustion or until the appearance of limiting symptoms and/or signs. The following parameters are measured: ventilation; oxygen consumption (VO2); carbon dioxide production (VCO2); and the other variables of conventional exercise testing. In addition, in specific situations, pulse oximetry and flow-volume loops during and after exertion are measured...
November 2016: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/27929571/an-unusual-mediastinal-mass
#20
J Hardy, A R Jeyabalan, N Bhatt, A R Medford
We report a case of a mediastinal mass indenting the left lateral tracheal wall of a 35-year-old male who presented with weight loss, cough and breathlessness. Flow volume loop and thyroid function tests were normal and thyroid peroxidase antibodies were negative. Technetium scintigraphy and positron emission tomography both showed no uptake. Endobronchial ultrasound-guided fine needle aspiration confirmed ectopic mediastinal thyroid tissue. Mediastinal ectopic thyroid tissue is very rare. Most patients are asymptomatic and euthyroid with positive signals on scintigraphy...
June 2016: Journal of the Royal College of Physicians of Edinburgh
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