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https://www.readbyqxmd.com/read/28737468/economic-evaluations-of-haemophilus-influenzae-type-b-hib-vaccine-a-systematic-review
#1
Bunchai Chongmelaxme, Maythika Hammanee, Wariya Phooaphirak, Surachai Kotirum, Raymond Hutubessy, Nathorn Chaiyakunapruk
AIMS: World Health Organization (WHO) recommends the use of Haemophilus influenzae type b (Hib) conjugate vaccines but only China and Thailand have not used Hib vaccination in their national immunization programs. This systematic review aimed to update published economic evaluations of Hib vaccinations and to determine factors that potentially affected their cost-effectiveness. METHODS: Searching was performed from the inception until December 2015 using 13 databases: CAB direct; CEA registry; EconLit; EMBASE; E-library; NHSEED; PAHO; POPLINE; PubMed; Redalyc project; RePEc; SciELO and WHOLIS...
July 24, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28729019/safety-reactogenicity-and-immunogenicity-of-two-investigational-pneumococcal-protein-based-vaccines-results-from-a-randomized-phase-ii-study-in-infants
#2
Roman Prymula, Leszek Szenborn, Sven-Arne Silfverdal, Jacek Wysocki, Piotr Albrecht, Magali Traskine, Asparuh Gardev, Yue Song, Dorota Borys
INTRODUCTION: Vaccination with formulations containing pneumococcal protein antigens such as pneumolysin toxoid (dPly) and histidine-triad protein D (PhtD) may extend serotype-related protection of pneumococcal conjugate vaccines (PCVs) against Streptococcus pneumoniae. METHODS: This phase II, multi-center, observer-blind trial conducted in Europe (NCT01204658) assessed 2 investigational vaccines containing 10 serotype-specific polysaccharide conjugates of PHiD-CV and either 10 or 30µg of dPly and PhtD each...
July 17, 2017: Vaccine
https://www.readbyqxmd.com/read/28702311/the-evidence-for-non-typeable-haemophilus-influenzae-as-a-causative-agent-of-childhood-pneumonia
#3
EDITORIAL
Mary P E Slack
Haemophilus influenzae type b (Hib) was a major cause of bacterial pneumonia in children prior to the introduction of Hib-conjugate vaccines. The widespread use of Hib-conjugate vaccines has resulted in a significant decline in the number of cases of invasive Hib disease, including bacteraemic pneumonia, in areas where the vaccine has been implemented. In many countries, non-typeable H. influenzae (NTHI) is now the most common cause of invasive haemophilus infection in all ages. NTHI are a recognized cause of bacteraemic and non-bacteraemic pneumonia in children and in adults...
2017: Pneumonia
https://www.readbyqxmd.com/read/28702307/childhood-pneumonia-and-meningitis-in-the-eastern-highlands-province-papua-new-guinea-in-the-era-of-conjugate-vaccines-study-methods-and-challenges
#4
Christopher C Blyth, Rebecca Ford, Joycelyn Sapura, Tonny Kumani, Geraldine Masiria, John Kave, Lapule Yuasi, Andrew Greenhill, Ilomo Hwaihwanje, Amanda Lang, Deborah Lehmann, William Pomat
BACKGROUND: Pneumonia and meningitis are common causes of severe childhood illness in Papua New Guinea (PNG). The etiology of both clinical conditions in PNG has not been recently assessed. Changes in lifestyle, provision and access to healthcare, antimicrobial utilization and resistance, and the national childhood vaccination schedule necessitate reassessment. METHODS: A prospective case-control study was undertaken, enrolling children <5 years of age to determine the contemporary etiology of clinically defined moderate or severe pneumonia or suspected meningitis...
2017: Pneumonia
https://www.readbyqxmd.com/read/28700282/a-randomized-open-label-clinical-trial-to-evaluate-immunogenicity-and-safety-of-an-indigenously-developed-dtwp-hib-tetravalent-combination-vaccine-easyfour%C3%A2-tt-with-quadrovax%C3%A2-in-indian-infants
#5
Lalitendu Mohanty, Sunil Sharma, Beauty Behera, Sachin Panwar, Charu Paliwal, Anit Singh, Anu Gupta, Deepak Chandra Chilkoti
An open-label, randomized, multi-centre trial was conducted to compare the immunogenicity and safety of an indigenously developed tetravalent DTwP-Hib vaccine, Easyfour®-TT with a commercially available vaccine, Quadrovax®. A total of 244 infants in good health, aged 6-10 weeks, were randomised in a 1:1 allocation to receive three doses of the test or comparator vaccine. Immunogenicity of the vaccines was determined by measuring the baseline and post-vaccination antibody response against the vaccine antigens; safety was evaluated in terms of local and systemic reactions (solicited and unsolicited) reported during the trial...
July 12, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28696824/age-appropriate-versus-up-to-date-coverage-of-routine-childhood-vaccinations-among-young-children-in-israel
#6
Chen Stein-Zamir, Avi Israeli
BACKGROUND AND AIMS: Routine childhood vaccinations schedules recommend that children receive the vaccine doses at specific ages. Vaccination coverage data are conventionally reported by the up-to-date method. We aimed to assess vaccination timeliness by the age-appropriate method and compare to the up-to-date vaccination coverage. METHODS: Assessment of age-appropriate and up-to-date vaccination coverage among children born in Israel in 2009 and followed to age 48 months (national representative sample, n = 3892)...
July 11, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28676382/new-perspectives-for-hexavalent-vaccines
#7
Pablo Obando-Pacheco, Irene Rivero-Calle, José Gómez-Rial, Carmen Rodríguez-Tenreiro Sánchez, Federico Martinón-Torres
With the increase in the number of routine vaccinations the development of pentavalent and hexavalent combination vaccines fitting the routine vaccination schedules became a necessity. In this respect, Europe has taken the lead in comparison with other world regions, and routine vaccination with pentavalent and hexavalent combinations including DTPa, Hib, HepB and IPV has been on European vaccination programs for >15years. Since the marketing authorization of Hexavac® and Infanrix Hexa® in 2000, immunization schedules in most European countries have included hexavalent vaccines...
July 1, 2017: Vaccine
https://www.readbyqxmd.com/read/28666758/the-changing-epidemiology-of-invasive-haemophilus-influenzae-disease-emergence-and-global-presence-of-serotype-a-strains-that-may-require-a-new-vaccine-for-control
#8
Raymond S W Tsang, Marina Ulanova
BACKGROUND: More than two decades after the implementation of the Hib conjugate vaccine in North America, Haemophilus influenzae serotype a (Hia) has emerged as a significant cause of invasive disease in Indigenous communities. However, little is known about the global presence of this pathogen. METHODS: We interrogated the H. influenzae Multi-Locus Sequence Typing (MLST) website (https://pubmlst.org/hinfluenzae/) by selecting for serotype a records. We also updated our previous literature review on this subject matter...
June 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28628438/haemophilus-influenzae-type-a-meningitis-in-immunocompetent-child-oman-2015
#9
Kiran P Sawardekar
Meningitis caused by Haemophilus influenzae type b (Hib) was eliminated in Oman after the introduction of Hib vaccine in 2001. However, a case of H. influenzae type a meningitis was diagnosed in a child from Oman in 2015, which highlights the need to monitor the incidence of invasive non-Hib H. influenzae disease.
July 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28624983/how-to-increase-vaccination-acceptance-among-apostolic-communities-quantitative-results-from-an-assessment-in-three-provinces-in-zimbabwe
#10
Regina Gerede, Zorodzai Machekanyanga, Serigne Ndiaye, Kenneth Chindedza, Colline Chigodo, Messeret E Shibeshi, James Goodson, Fussum Daniel, Reinhard Kaiser
A worldwide increasing trend toward vaccine hesitancy has been reported. Measles outbreaks in southern Africa in 2009-2010 were linked to objections originating from Apostolic gatherings. Founded in Zimbabwe in the 1950s, the Apostolic church has built up a large number of followers with an estimated 3.5 million in Zimbabwe in 2014. To inform planning of interventions for the 2015 measles-rubella vaccination campaign, we assessed vaccination status and knowledge, attitudes and practices among purposive samples of Apostolic caregivers in three districts each in Harare City, Manicaland and Matabeleland South in Zimbabwe...
June 17, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28583305/immunogenicity-and-safety-of-a-new-hexavalent-vaccine-dtap5-ipv-hb-hib-administered-in-a-mixed-primary-series-schedule-with-a-pentavalent-vaccine-dtap5-ipv-hib
#11
Federico Martinón-Torres, Florence Boisnard, Stéphane Thomas, Christine Sadorge, Ray Borrow
DTaP5-IPV-HB-Hib vaccine is a fully-liquid, combination hexavalent vaccine. This phase III, open-label, multicentre study conducted in Spain, evaluated the immune response to all DTaP5-IPV-HB-Hib antigens when the vaccine was used in a mixed hexa/penta/hexa primary series. Infants (who had received one dose of hepatitis B vaccine at birth) received a mixed schedule including DTaP5-IPV-HB-Hib (PRP-OMP conjugate) at 2 and 6months of age, DTaP5-IPV-Hib at 4months, meningococcal serogroup C conjugate (MCC) vaccine at 2 and 4months, and routine rotavirus and pneumococcal vaccination...
June 2, 2017: Vaccine
https://www.readbyqxmd.com/read/28536030/lot-to-lot-consistency-safety-and-immunogenicity-of-3-lots-of-haemophilus-influenzae-type-b-conjugate-vaccine-results-from-a-phase-iii-randomized-multicenter-study-in-infants
#12
Nicola P Klein, Remon Abu-Elyazeed, Matthew Cornish, Michael L Leonardi, Leonard B Weiner, Peter E Silas, Stanley E Grogg, Meera Varman, Robert W Frenck, Brigitte Cheuvart, Yaela Baine, Jacqueline M Miller, Maarten Leyssen, Narcisa Mesaros, Sumita Roy-Ghanta
BACKGROUND: Vaccination against Haemophilus influenzae type b (Hib) is included in routine pediatric immunization schedule in the United States. Previous vaccine shortages have created the need for additional options for Hib vaccination. METHODS: This phase III, randomized, multi-centered study (NCT01000974) evaluated the safety and immunogenicity of a monovalent tetanus toxoid-conjugate Hib vaccine (Hib-TT) compared to a monovalent (Hib-TT control) and a combination Hib-TT vaccine...
May 20, 2017: Vaccine
https://www.readbyqxmd.com/read/28536027/live-attenuated-tetravalent-g1-g4-bovine-human-reassortant-rotavirus-vaccine-brv-tv-randomized-controlled-phase-iii-study-in-indian-infants
#13
Tarun Saluja, Sonali Palkar, Puneet Misra, Madhu Gupta, Potula Venugopal, Ashwani Kumar Sood, Ravi Mandyam Dhati, Avinash Shetty, Sangappa Malappa Dhaded, Sharad Agarkhedkar, Amlan Choudhury, Ramesh Kumar, Sundaram Balasubramanian, Sudhir Babji, Lopa Adhikary, Martin Dupuy, Sangeet Mohan Chadha, Forum Desai, Darshna Kukian, Badri Narayan Patnaik, Mandeep Singh Dhingra
BACKGROUND: Rotavirus remains the leading cause of diarrhoea among children <5years. We assessed immunogenic non-inferiority of a tetravalent bovine-human reassortant rotavirus vaccine (BRV-TV) over the licensed human-bovine pentavalent rotavirus vaccine RV5. METHODS: Phase III single-blind study (parents blinded) in healthy infants randomized (1:1) to receive three doses of BRV-TV or RV5 at 6-8, 10-12, and 14-16weeks of age. All concomitantly received a licensed diphtheria, tetanus, pertussis, hepatitis B, Haemophilus influenzae type b conjugate vaccine (DTwP-HepB-Hib) and oral polio vaccine (OPV)...
May 20, 2017: Vaccine
https://www.readbyqxmd.com/read/28504487/haemophilus-influenzae-type-b-meningitis-is-there-a-re-emergence-24-years-of-experience-in-a-children-s-hospital
#14
Angela Gentile, Ana C Martínez, María Del V Juarez, María F Lución, Candela Burgo, María P Della Latta, Solana Rapapor, Viviana Romanin, Marisa Turco
INTRODUCTION: Haemophilus influenzae type B (Hib) used to be the main cause of bacterial meningitis in children younger than 5 years old. Following the introduction of the Hib vaccine in the immunization schedule (1998), its incidence reduced significantly but it has increased over the last years. The objectives of this study included describing the characteristics and analyzing the epidemic curve of Haemophilus influenzae type B (Hib) meningitis by comparing the pre- and postimmunization periods...
June 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28498097/the-asplenic-patient-post-insult-immunocompetence-infection-and-vaccination
#15
Brandon Dionne, Walter Dehority, Meghan Brett, Thomas R Howdieshell
BACKGROUND: Splenic injury can occur through multiple mechanisms and may result in various degrees of residual immunocompetence. Functionally or anatomically asplenic patients are at higher risk for infection, particularly with encapsulated bacteria. Vaccination is recommended to prevent infection with these organisms; however, the recommendations are routinely updated, and vaccine selection and timing are complex. METHODS: Review of the pertinent English-language literature, including the recommendations of the U...
July 2017: Surgical Infections
https://www.readbyqxmd.com/read/28464987/utilizing-pharmacy-intervention-in-asplenic-patients-to-improve-vaccination-rates
#16
Lindsey Rihtarchik, Claire V Murphy, Kyle Porter, Lisa Mostafavifar
PURPOSE: Asplenic patients are at increased risk for post-splenectomy infection caused by Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae type B (Hib), and vaccination rates against these organisms remain low. The purpose of this study was to evaluate vaccination rates before and after implementation of a pharmacist-driven electronic vaccination tracking system. METHODS: This retrospective cohort analysis compared adult splenectomy patients before and after implementation of a pharmacist-driven tracking system with a primary outcome of complete initial vaccination...
April 24, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28463499/advancing-homogeneous-antimicrobial-glycoconjugate-vaccines
#17
Roberto Adamo
Since 2004, when the first synthetic glycoconjugate vaccine against the pneumonia and meningitis causing bacterium Haemophilus influenza type b (Hib) approved for human use in Cuba was reported, 34 million doses of the synthetic vaccine have been already distributed in several countries under the commercial name of Quimi-Hib. However, despite the success of this product, no other synthetic glycoconjugate vaccine has been licensed in the following 13 years. As well as avoiding the need to handle pathogens, synthetic glycoconjugates offer clear advantages in terms of product characterization and the possibility to understand the parameters influencing immunogenicity...
May 16, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28456490/pediatric-bacterial-meningitis-in-japan-2013-2015-3-5-years-after-the-wide-use-of-haemophilus-influenzae-type-b-and-streptococcus-pneumoniae-conjugated-vaccines
#18
Masayoshi Shinjoh, Yoshio Yamaguchi, Satoshi Iwata
BACKGROUND: Haemophilus influenzae type b (Hib) vaccine and pneumococcal conjugated vaccine (PCV) have been widely used since 2010 in Japan when both vaccines were supported by the regional governments, and they were covered as routine recommended vaccines in 2013. The incidence of bacterial meningitis due to these organisms decreased in 2011 and 2012, but meningitis due to Streptococcus agalactiae and Escherichia coli remained unchanged. OBJECTIVES: We planned to confirm whether the incidence also decreased in subsequent years...
April 26, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28450511/complete-genome-sequence-of-bordetella-pertussis-pelita-iii-the-production-strain-for-an-indonesian-whole-cell-pertussis-vaccine
#19
Yusuf Sofyan Efendi, Dwi Susanti, Erman Tritama, Michelle Lueders Pasier, Gilang Nadia Niwan Putri, Sugeng Raharso, Iskandar, Pingkan Aditiawati, Ernawati Arifin Giri-Rachman, Biswarup Mukhopadhyay, Endang Purwantini
PT Bio Farma, the sole World Health Organization-approved Indonesian vaccine producer, manufactures a whole-cell whooping cough vaccine (wP) that, as part of a pentavalent diphtheria-tetanus-pertussis/hepatitis B/Haemophilus influenzae b (DTP/HB/Hib) vaccine, is used in Indonesia and many other countries. We report here the whole-genome sequence for Bordetella pertussis Pelita III, PT Bio Farma's wP production strain.
April 27, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28449972/effect-of-prophylactic-or-therapeutic-administration-of-paracetamol-on-immune-response-to-dtwp-hepb-hib-combination-vaccine-in-indian-infants
#20
Arijit Sil, Mandyam D Ravi, Badri N Patnaik, Mandeep S Dhingra, Martin Dupuy, Dulari J Gandhi, Sangappa M Dhaded, Anand P Dubey, Ritabrata Kundu, Sanjay K Lalwani, Jugesh Chhatwal, Leni G Mathew, Madhu Gupta, Shiv D Sharma, Sandeep B Bavdekar, Soumya P Rout, Midde V Jayanth, Naveena A D'Cor, Somnath A Mangarule, Suresh Ravinuthala, Jagadeesh Reddy E
BACKGROUND: Vaccination is considered as the most cost effective method for preventing infectious diseases. Low grade fever is a known adverse effect of vaccination. In India, it is a common clinical practice to prescribe paracetamol either prophylactically or therapeutically to manage fever. Some studies have shown that paracetamol interferes with antibody responses following immunization. This manuscript reports the outcome of a post hoc analysis of data from a clinical trial of a pentavalent vaccine in Indian infants where paracetamol was not used or was used either as prophylaxis or for treatment of fever...
May 19, 2017: Vaccine
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