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https://www.readbyqxmd.com/read/28103054/interface-related-attributes-of-the-maillard-reaction-born-glycoproteins
#1
Mehri Karbasi, Ashkan Madadlou
Interfacial behavior of proteins which is a chief parameter to their emulsifying and foaming properties can be tailored through the Maillard reaction. The reaction can increase protein solubility at isoelectric point and ought to be controlled for example by high pressure processing to suppress melanoidins formation. Branched and long saccharides bring considerable steric hindrance which is associated with their site of conjugation to proteins. Conjugation with high molecular weight polysaccharides (such as 440 kDa dextran) may indeed increase the thickness of globular proteins interfacial film up to approximately 25 nm...
January 19, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28102669/intervention-of-isomaltodextrin-mitigates-intestinal-inflammation-in-a-dextran-sodium-sulfate-induced-mouse-model-of-colitis-via-inhibition-of-toll-like-receptor-4
#2
Kaustav Majumder, Toshihiko Fukuda, Hua Zhang, Takeo Sakurai, Yoshifumi Taniguchi, Hikaru Watanabe, Hitoshi Mitsuzumi, Toshiro Matsui, Yoshinori Mine
Isomaltodextrin (IMD), a highly branched α-glucan, is a type of resistant starch. Earlier studies have indicated that polysaccharides could prevent inflammation and can be effective in reducing the complications of chronic gastrointestinal diseases such as inflammatory bowel disease (IBD). Therefore, the aim of the present study was to evaluate the anti-inflammatory effect of IMD in dextran sodium sulfate (DSS)-induced colitis in a mouse model. IMD (0.5, 1.0, 2.5, and 5.0% (w/v)) was given orally for 23 days to female Balb/c mice, and then 5% DSS was administered to induce colitis (from day 15 onward to the end of the trial)...
January 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28098144/oligo-fucoidan-prevents-renal-tubulointerstitial-fibrosis-by-inhibiting-the-cd44-signal-pathway
#3
Cheng-Hsien Chen, Yuh-Mou Sue, Chung-Yi Cheng, Yen-Cheng Chen, Chung-Te Liu, Yung-Ho Hsu, Pai-An Hwang, Nai-Jen Huang, Tso-Hsiao Chen
Tubulointerstitial fibrosis is recognized as a key determinant of progressive chronic kidney disease (CKD). Fucoidan, a sulphated polysaccharide extracted from brown seaweed, exerts beneficial effects in some nephropathy models. The present study evaluated the inhibitory effect of oligo-fucoidan (800 Da) on renal tubulointerstitial fibrosis. We established a mouse CKD model by right nephrectomy with transient ischemic injury to the left kidney. Six weeks after the surgery, we fed the CKD mice oligo-fucoidan at 10, 20, and 100 mg/kg/d for 6 weeks and found that the oligo-fucoidan doses less than 100 mg/kg/d improved renal function and reduced renal tubulointerstitial fibrosis in CKD mice...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28094275/sulfated-cyclocarya-paliurus-polysaccharides-markedly-attenuates-inflammation-and-oxidative-damage-in-lipopolysaccharide-treated-macrophage-cells-and-mice
#4
Zhijun Wang, Jianhua Xie, Yujiao Yang, Fan Zhang, Shengnan Wang, Ting Wu, Mingyue Shen, Mingyong Xie
Natural polysaccharides and their modified derivatives are crucial supplements to the prevention of inflammation. This study aimed to evaluate the effect of sulfated modification on the anti-inflammatory and anti-oxidative activities of Cyclocarya paliurus polysaccharides (CP). A sulfated CP, S-CP1-4 was obtained using chlorosulfonic acid-pyridine method. The chemical components and FT-IR spectrum confirmed that sulfated group was synthesized to the polysaccharide chains successfully. S-CP1-4 was found to inhibit nitric oxide production, phagocytic activity and the release of interleukin (IL)-6 and IL-1β in lipopolysaccharide-treated macrophage cells, RAW 264...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28087447/structures-biological-activities-and-industrial-applications-of-the-polysaccharides-from-hericium-erinaceus-lion-s-mane-mushroom-a-review
#5
REVIEW
Xirui He, Xiaoxiao Wang, Jiacheng Fang, Yu Chang, Ning Ning, Hao Guo, Linhong Huang, Xiaoqiang Huang, Zefeng Zhao
Hericium erinaceus (Bull.) Pers., also known as Yamabushitake, Houtou and Lion's Mane, is capable of fortifying the spleen and nourishing the stomach, tranquilizing the mind, and fighting cancer. Over the past decade, it has been demonstrated that H. erinaceus polysaccharides possess various promising bioactivities, including antitumor and immunomodulation, anti-gastric ulcer, neuroprotection and neuroregeneration, anti-oxidation and hepatoprotection, anti-hyperlipidemia, anti-hyperglycemia, anti-fatigue and anti-aging...
January 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28087233/anti-diabetic-effects-of-inonotus-obliquus-polysaccharides-chromium-iii-complex-in-type-2-diabetic-mice-and-its-sub-acute-toxicity-evaluation-in-normal-mice
#6
Cong Wang, Zhongqin Chen, Yuxiang Pan, Xudong Gao, Haixia Chen
Polysaccharides are important bioactive ingredients from Inonotus obliquus. This study aimed to synthesize and characterize a novel I. obliquus polysaccharides-chromium (III) complex (UIOPC) and investigate the anti-diabetic effects in streptozotocin (STZ) induced type 2 diabetes mellitus (T2DM) mice and sub-acute toxicity in normal mice. The molecular weight of UIOPC was about 11.5 × 10 (4) Da with the chromium content was 13.01% and the chromium was linked with polysaccharides through coordination bond...
January 10, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28069358/pneumococcal-polysaccharide-vaccination-administered-early-after-neurotrauma-or-neurosurgery
#7
Anna Ljunghill Hedberg, Karlis Pauksens, Per Enblad, Jessika Söderberg, Björn Johansson, Helena Käyhty, Jan Sjölin
OBJECTIVES: Pneumococcal vaccination is recommended to lower the risk of posttraumatic meningitis, and early vaccination may be of importance. After both trauma and central nervous system injury, immune-suppression may occur, which could affect T-cell function and the response to T-cell dependent vaccines. We therefore aimed to investigate the response to early vaccination with a T-cell independent pneumococcal polysaccharide vaccine (PPSV). METHODS: Thirty-three patients with basilar skull fracture and 23 patients undergoing transsphenoidal pituitary gland surgery were vaccinated with PPSV within 10days after neurotrauma or neurosurgery...
January 6, 2017: Vaccine
https://www.readbyqxmd.com/read/28064049/anti-diarrhoeal-therapeutic-potential-and-safety-assessment-of-sulphated-polysaccharide-fraction-from-gracilaria-intermedia-seaweed-in-mice
#8
Ana Carolina M Leódido, Luis E C Costa, Thiago S L Araújo, Douglas S Costa, Nayara A Sousa, Luan K M Souza, Francisca B M Sousa, Manoel D S Filho, Daniel F P Vasconcelos, Felipe R P Silva, Kerolayne M Nogueira, Alyne R Araújo, Francisco Clark N Barros, Ana Lúcia P Freitas, Jand Venes R Medeiros
Sulphated polysaccharides extracted from algae have been extensively studied for their diverse biological activities. Thus, the purpose of this study was to evaluate the chemical composition, the anti-diarrhoeal effect and acute toxicity of a sulphated polysaccharide fraction obtained from Gracilaria intermedia (SP-Gi). Initially, the FT-IR of SP-Gi revealed to be an agaran with sulphation at C-6 of the l-galactosyl residues. The anti-diarrhoeal activity of SP-Gi was evaluated in a castor oil-induced diarrhoea model...
January 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28062237/physico-chemical-characterization-and-pharmacological-activities-of-sulfated-polysaccharide-from-sea-urchin-paracentrotus-lividus
#9
Yosra Ben Salem, Safa Amri, Khaoula Mkadmini Hammi, Amal Abdelhamid, Didier Le Cerf, Abderrahman Bouraoui, Hatem Majdoub
Sulfated polysaccharide (SP) from the eggs of sea urchin Paracentrotus lividus, extracted by papain digestion, was characterized by size exclusion chromatography coupling on-line with light scattering and viscosity detectors (SEC/MALS/VD/DRI), gas chromatography coupled to mass spectrometer (GC-MS), and Fourier transform infrared spectroscopy (FTIR) analysis. The native molecular mass of the extracted polysaccharide is high (≥22 000 KDa) and it is composed mainly of arabinose, accompanied by other monosaccharides (mostly galactose, glucose and fucose), significant amounts of uronic acids (18...
January 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28052202/selenylation-of-polysaccharide-from-the-sweet-potato-and-evaluation-of-antioxidant-antitumor-and-antidiabetic-activities
#10
Bo Yuan, Xu-Qin Yang, Meng Kou, Chang-Yan Lu, Yuan-Yuan Wang, Jun Peng, Ping Chen, Ji-Hong Jiang
Interest in sweet potato as a functional food is growing. A polysaccharide (SWP) was isolated from the sweet potato tuber and elucidation of its structure as composed of rhamnose, glucose, and galactose undertaken. To improve its activity, selenylation of this novel polysaccharide (Se-SWP) was undertaken by using microwave synthesis. In vitro evaluation showed that the Se-SWP has excellent antioxidant activity on scavenging free radicals and reducing capacity. In vivo antitumor evaluation showed selenylation polysaccharide could effectively inhibit tumor growth (>50%) and adjust immune factor levels in the mice (IL-2, TNF-α, and VEGF)...
January 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28049392/chondroitin-sulfate-cs-lyases-structure-function-and-application-in-therapeutics
#11
Aruna Rani, Seema Patel, Arun Goyal
Glycosaminoglycans (GAGs) such as chondroitin sulfate (CS) are the chief natural polysaccharides which reside in biological tissues mainly in extracellular matrix. These CS along with adhesion molecules and growth factors are involved in central nervous system (CNS) development, cell progression and pathogenesis. The chondroitin lyases are the enzyme that degrade and alter the CS chains and hence modify various signalling pathways involving CS chains. These CS lyases are substrate specific, can precisely manipulate the CS polysaccharides and have various biotechnological, medical and therapeutic applications...
January 2, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28049369/immunocytochemical-detection-of-rhamnogalacturonan-ii-on-forming-cell-plates-in-cultured-tobacco-cells
#12
Ye Zhou, Tatsuya Awano, Masaru Kobayashi, Toru Matoh, Keiji Takabe
Rhamnogalacturonan II (RG-II) is a region of pectin macromolecules that is present in plant primary cell walls. The RG-II region serves as the site of borate cross-linking within pectin, via which pectin macromolecules link together to form a gel. In this study, we examined whether RG-II is present in the cell plate, the precursor of primary cell walls that forms during cytokinesis. A structure inside dividing cells was labeled with a rabbit polyclonal anti-RG-II antibody and detected by immunofluorescence microscopy...
January 4, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28043326/advances-and-prospects-in-biogenic-substances-against-plant-virus-a-review
#13
REVIEW
Lei Zhao, Chaohong Feng, Kuan Wu, Wenbao Chen, Yujia Chen, Xingan Hao, Yunfeng Wu
Plant virus diseases, known as 'plant cancer', are the second largest plant diseases after plant fungal diseases, which have caused great damage to agricultural industry. Since now, the most direct and effective method for controlling viruses is chemotherapeutics, except for screening of anti-disease species. As the occurrence and harm of plant diseases intensify, production and consumption of pesticides have increased year by year, and greatly contributed to the fertility of agriculture, but also brought a series of problems, such as the increase of drug resistance of plant pathogens and the excessive pesticide residues...
January 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28043052/remote-controlled-drug-release-from-multi-functional-fe3o4-go-chitosan-microspheres-fabricated-by-an-electrospray-method
#14
Sheng Li, Ling Xiao, Hongbing Deng, Xiaowen Shi, Qihua Cao
The construction of multifunctional microspheres for remote controlled drug release requires the exquisite selection of composite materials and preparation approaches. In this study, chitosan, an amino polysaccharide, was blended with inorganic nanocomponents, Fe3O4 and graphene oxide (GO) and electrosprayed to fabricate uniform microspheres with the diameters ranging from 100μm to 1100μm. An anti-cancer drug, doxorubicin (DOX), was loaded to the microspheres by an adsorption or embedding method. The microsphere is responsive to magnetic fields due to the presence of Fe3O4, and the incorporation of GO enhanced the drug loading capacity...
December 23, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28042854/in-vitro-anti-thrombotic-activity-of-extracts-from-blacklip-abalone-haliotis-rubra-processing-waste
#15
Hafiz Ansar Rasul Suleria, Barney M Hines, Rama Addepalli, Wei Chen, Paul Masci, Glenda Gobe, Simone A Osborne
Waste generated from the processing of marine organisms for food represents an underutilized resource that has the potential to provide bioactive molecules with pharmaceutical applications. Some of these molecules have known anti-thrombotic and anti-coagulant activities and are being investigated as alternatives to common anti-thrombotic drugs, like heparin and warfarin that have serious side effects. In the current study, extracts prepared from blacklip abalone (Haliotis rubra) processing waste, using food grade enzymes papain and bromelain, were found to contain sulphated polysaccharide with anti-thrombotic activity...
December 31, 2016: Marine Drugs
https://www.readbyqxmd.com/read/28041916/preparation-and-characterization-of-oxidized-starch-poly-n-n-dimethylaminoethyl-methacrylate-semi-ipn-cryogels-and-in-vitro-controlled-release-evaluation-of-indomethacin
#16
Diana Felicia Apopei Loghin, Gabriela Biliuta, Sergiu Coseri, Ecaterina Stela Dragan
Fabrication of novel semi-interpenetrating polymer network (semi-IPN) cryogels by cross-linking polymerization of N,N-dimethylaminoethyl methacrylate (DMAEM) in the presence of either oxidized potato starch (OPS) or oxidized wheat starch (OWS) and their characterization are presented in the paper. The influence of the nature of entrapped polymer on the properties of the composite cryogels was evaluated by the swelling kinetics, FT-IR spectroscopy, scanning electron microscopy, and response at external stimuli such as temperature, pH, and ionic strength...
December 29, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28035976/meadowsweet-teas-as-new-functional-beverages-comparative-analysis-of-nutrients-phytochemicals-and-biological-effects-of-four-filipendula-species
#17
Daniil N Olennikov, Nina I Kashchenko, Nadezhda K Chirikova
In recent years, the increased popularity of functional beverages such as herbal teas and decoctions has led to the search for new sources of raw materials that provide appropriate taste and functionality to consumers. The objective of this study was to investigate the nutritional, phytochemical profiles and bioactivities of possible functional beverages produced from F. ulmaria and its alternative substitutes (F. camtschatica, F. denudata, F. stepposa). The investigated decoctions were analyzed regarding their macronutrient, carbohydrate, organic acid, amino acid and mineral composition...
December 26, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28031178/otitis-prone-children-produce-functional-antibodies-to-pneumolysin-and-pneumococcal-polysaccharides
#18
Lea-Ann S Kirkham, Selma P Wiertsema, Karli J Corscadden, Tulia Mateus, Gemma L Mullaney, Guicheng Zhang, Peter C Richmond, Ruth B Thornton
BACKGROUND: The pneumococcus is a major otitis media (OM) pathogen but data are conflicting on whether otitis-prone children have impaired humoral immunity to pneumococcal antigens. We and others have shown that otitis-prone and healthy children have similar antibody titres to pneumococcal proteins and polysaccharides (vaccine and non-vaccine type), however the quality of antibodies from otitis-prone children has not been investigated. Antibody function, rather than titre, is considered to better correlate with protection from pneumococcal disease...
December 28, 2016: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28024547/metrics-of-rhamnogalacturonan-i-with-%C3%AE-1%C3%A2-4-linked-galactan-side-chains-and-structural-basis-for-its-self-aggregation
#19
Olga N Makshakova, Tatyana A Gorshkova, Polina V Mikshina, Yuriy F Zuev, Serge Perez
Within the family of plant cell wall polysaccharides rhamnogalacturonans I are the most diverse and structurally complex members. In present study we characterize the 3-dimensional structures and dynamic features of the constituents of RG-I along MD trajectories. It is demonstrated that extended threefold helical structure of the rhamnogalacturonan linear backbone is the most energetically favorable motif. Branching helps to stabilize a conformer of the backbone twisted along 1→2 glycosidic linkage triggering the orientation of long side chains without altering the extended overall backbone chain conformation...
February 20, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28011954/new-cationically-modified-pullulan-attenuates-atherogenesis-and-influences-lipid-metabolism-in-apoe-knockout-mice
#20
J Stefan, K Kus, A Wisniewska, K Kaminski, K Szczubialka, J Jawien, M Nowakowska, R Korbut
Pullulan is a biocompatible polysaccharide obtained from black, yeast-like fungus Aureobasidium pullulans. This polymer is used to deliver various substances to the liver because of its specificity for this organ. Pullulan is internalized into hepatocytes in the process of asialoglycoprotein receptor mediated endocytosis. Recently, by reaction with glycidyltrimethylammonium chloride (GTMAC) we have successfully synthesized a cationically-modified pullulan (Pull-GTMAC). Pull-GTMAC exhibits some unique beneficial effects not found for its native counterpart...
October 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
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