keyword
MENU ▼
Read by QxMD icon Read
search

Anti polysaccharide

keyword
https://www.readbyqxmd.com/read/29452699/hypolipidemic-components-from-medicine-food-homology-species-used-in-china-pharmacological-and-health-effects
#1
REVIEW
De-Xing Song, Jian-Guo Jiang
Hyperlipidemia is a systemic disease caused by abnormal human lipid metabolism. Dietary control and treatment on hyperlipidemia is now a popular therapy pathway. This paper focuses on the medicine food homology (MFH) species used in China with hypolipidemic function, and emphasizes on the active ingredients and their pharmacological effect. The single herbal and its hypolipidemic active ingredients are summarized through reviewing the relevant literatures published in the past twenty years. The ingredients are divided into polysaccharides, flavonoids, steroidal saponins, quinones, alkaloids and others, of which the related researches are described from the aspects of sources, model and method, result and mechanisms, respectively...
February 13, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29452183/purification-structural-elucidation-and-anti-inflammatory-activity-of-xylosyl-galactofucan-from-armillariella-mellea
#2
Chia-Chuan Chang, Jing-Jy Cheng, I-Jung Lee, Mei-Kuang Lu
A xylosyl galactofucan (AMPS-III) was isolated and identified as a novel anti-inflammatory agent from an edible fungus, Armillariella mellea. The characteristics chemical structure of AMPS-III including the linkages of compositional monosaccharides and structure of the repeat unit were depicted and elucidated by proton, carbon and two-dimensional nuclear magnetic resonance techniques. AMPS-III was chemically proposed to have a partial 4‑O‑xylosylated 1,3-linked α‑d‑galactosyl-interlaced α‑l‑fucan composed of a pentadecasaccharide repeat unit with a molecular mass approximately 13 kDa, as shown below...
February 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29448627/polysaccharide-functionalized-single-walled-carbon-nanotubes-as-nanocarriers-for-delivery-of-curcumin-in-lung-cancer-cells
#3
Neha Singh, Abhay Sachdev, P Gopinath
Nanoscale drug delivery systems have emerged as promising alternatives to overcome the problems associated with by conventional chemotherapy for cancer treatment such as poor drug stability and bio-distribution. Herein, we report a single walled carbon nanotubes (SWCNTs) based drug delivery system functionalized with polysaccharides such as alginate (ALG) and chitosan (CHI), which can be loaded with an anticancer drug curcumin (CUR). Modification of SWCNTs renders high drug loading efficiency and sustained drug release, imperative for drug activity...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29447962/low-molecular-weight-fucoidan-attenuates-liver-injury-via-sirt1-ampk-pgc1%C3%AE-axis-in-db-db-mice
#4
Yuanyuan Zheng, Tiantian Liu, Zhiqiang Wang, Yang Xu, Quanbin Zhang, Dali Luo
Non-alcoholic fatty-liver disease (NAFLD), caused by elevated hepatic lipids, inflammation and oxidative stress, is the most common liver disease globally. Low molecular weight fucoidan (LMWF), a sulfated polysaccharide extracted from brown seaweeds, has shown strong anti-inflammatory and antioxidant activities, which has not been explored in diabetes-induced NAFLD. Therefore, the present study sought to determine whether LMWF protects obese diabetic db/db mice against NAFLD. Results showed LMWF administration decreased plasma level of alanine aminotransferase, aspartate aminotransferase, total cholesterol, and triglyceride, as well as alleviated hepatic accumulation of triglyceride and total cholesterol in db/db mice...
February 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29442909/synthetic-polysaccharides-as-drug-carriers-synthesis-of-polyglucose-amphotericin-b-conjugates-and-in-vitro-evaluation-of-their-anti-fungal-and-anti-leishmanial-activities
#5
Vasanthan Ravichandran, Gayathri P Kothandaraman, Christian Bories, Philippe M Loiseau, A Jayakrishnan
While many naturally occurring polysaccharides have been widely used as drug carriers, there are two main drawbacks in their use: the first is their physical properties such as molecular weight, branching, type of glycosidic linkages and solubility depend on their source and the method of isolation and purification, the second is many of them are contaminated with proteins and protein removal is essential for preventing immune reactions. Synthetic polysaccharides on the other hand can be tailor made from their respective monomers with consistent physical properties and are, free from protein contamination, both being significant advantages in their use...
April 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442290/the-optimisation-of-the-expression-of-recombinant-surface-immunogenic-protein-of-group-b-streptococcus-in-escherichia-coli-by-response-surface-methodology-improves-humoral-immunity
#6
Diego A Díaz-Dinamarca, José I Jerias, Daniel A Soto, Jorge A Soto, Natalia V Díaz, Yessica Y Leyton, Rodrigo A Villegas, Alexis M Kalergis, Abel E Vásquez
Group B Streptococcus (GBS) is the leading cause of neonatal meningitis and a common pathogen in livestock and aquaculture industries around the world. Conjugate polysaccharide and protein-based vaccines are under development. The surface immunogenic protein (SIP) is a conserved protein in all GBS serotypes and has been shown to be a good target for vaccine development. The expression of recombinant proteins in Escherichia coli cells has been shown to be useful in the development of vaccines, and the protein purification is a factor affecting their immunogenicity...
February 13, 2018: Molecular Biotechnology
https://www.readbyqxmd.com/read/29434755/anti-tumour-effects-of-polysaccharide-extracted-from-acanthopanax-senticosus-and-cell-mediated-immunity
#7
Qinglong Meng, Jingzhi Pan, Yajing Liu, Li Chen, Yueying Ren
Acanthopanax senticosus, also known as Siberian ginseng, is widely distributed throughout northern Asia and used in traditional Chinese medicine; it has been reported to prevent a number of diseases. However, the association between the antitumour and immunostimulatory activities of polysaccharide extracted from A. senticosus (ASPS) remains to be elucidated. The aim of the present study was to investigate the anti-tumour and immunomodulatory effects of polysaccharide extracted from ASPS on Crocker sarcoma S180, hepatic carcinoma H22 and uterine cervical carcinoma U14 tumour cell lines implanted in mice...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29433787/fruits-and-vegetables-as-a-source-of-nutritional-compounds-and-phytochemicals-changes-in-bioactive-compounds-during-lactic-fermentation
#8
Axelle Septembre-Malaterre, Fabienne Remize, Patrick Poucheret
Nutritional recommendations emphasize fruit and vegetable consumption. This is related to health-benefits associated with bioactive nutritive molecules (nutrients, vitamins, minerals, fibers, …) as well as non-nutritive phytochemicals (phenolic compounds, flavonoids, bioactive peptides, …) content of these types of foods. Fermented fruit or vegetable products are part of various diets worldwide. Lactic acid bacteria (LAB) fermentation is common among the various fermentation processes used. It produces changes in both profile and types of bioactive compounds...
February 2018: Food Research International
https://www.readbyqxmd.com/read/29432833/structure-of-an-entangled-heteropolysaccharide-from-pholidota-chinensis-lindl-and-its-antioxidant-and-anti-cancer-properties
#9
Dianhui Luo, Zhaojing Wang, Zhiming Li, Xiao-Qiang Yu
A major polysaccharide PCP-I was isolated and purified from Pholidota chinensis Lindl. The physicochemical and structural properties of PCP-I were studied using high-performance size-exclusion chromatography (HPSEC), gas chromatography (GC), Fourier transform infrared spectroscopy (FTIR), periodate oxidation-smith degradation, methylation-GC-MS analysis, nuclear magnetic resonance (NMR) spectroscopy and transmission electron microscopy (TEM) analysis. PCP-I was homogeneous with molecular weight (Mw) of 249 kDa and composed of xylose and fucose at a molar ratio of 2...
February 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29432052/protective-effects-of-enteral-nutrition-supplemented-with-crassostrea-hongkongensis-polysaccharides-against-5-fluorouracil-induced-intestinal-mucosal-damage-in-rats
#10
Bingna Cai, Peng Wan, Huili Sun, Deke Chen, Hua Chen, Xin Chen, Jianyu Pan
Chemotherapeutics, including 5-fluorouracil (5-FU), often damage the intestinal mucosal barrier and cause intestinal mucositis (IM). Supplementation with immunoregulatory polysaccharides from Crassostrea hongkongensis has been shown to positively influence the effectiveness and toxicity of 5-FU. Therefore, we studied the effects of oyster polysaccharides on 5-FU-induced intestinal mucosal damage in rats. The C30-60% ethanol-precipitated fraction of polysaccharides promoted IEC-6 cell proliferation and exhibited a maximal effect at a 0...
February 12, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29432051/immunogenicity-and-persistence-of-a-prime-boost-re-vaccination-strategy-for-pneumococcal-vaccines-in-patients-with-rheumatoid-arthritis
#11
Mathilde Bahuaud, Constance Beaudouin-Bazire, Marine Husson, Anna Molto, Odile Launay, Frédéric Batteux, Maxime Dougados
OBJECTIVES: Patients with rheumatoid arthritis (RA) are at an increased risk of Pneumococcal infections. Immunogenicity and persistence of a prime-boost revaccination strategy using 13-valent/23-valent anti-pneumococcal vaccines was evaluated in patients with RA treated by Methotrexate (MTX) and anti-TNF. METHOD: Twenty-four patients with RA received one dose of PCV13 (Prevenar13ࣨ; Pfizer) followed two months later by one dose of PPV23 (Pneumovax®, Merck). Concentrations of IgG specific for 7 serotypes common to both vaccines and 3 uncommon serotypes, included only in the PPV23 were measured by ELISA and Opsonophagocytic Assay (OPA) at baseline and after 4, 12 and 24 months post-vaccine...
February 12, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29430962/effect-of-a-mouthrinse-containing-malva-sylvestris-on-the-viability-and-activity-of-microcosm-biofilm-and-on-enamel-demineralization-compared-to-known-antimicrobials-mouthrinses
#12
Aline Silva Braga, Juliana Gonçalves Pires, Ana Carolina Magalhães
The purpose of this study was to evaluate the antimicrobial (anti-biofilm) and anti-caries (enamel demineralization prevention) effects of Malva sylvestris (Malvatricin® Plus) compared with known antimicrobial mouthrinses. Microcosm biofilm was produced on enamel, using inoculum from pooled human saliva mixed with McBain saliva (0.2% sucrose) for 14 days. The biofilm was treated with mouthrinses for 1 min day-1. Oral-B® Complete, Listerine® Zero and Malvatricin® Plus had the greatest effect on the reduction of biofilm viability (p < 0...
February 11, 2018: Biofouling
https://www.readbyqxmd.com/read/29428385/cognitive-enhancing-effect-of-polysaccharides-from-flammulina-velutipes-on-alzheimer-s-disease-by-compatibilizing-with-ginsenosides
#13
Yan Zhang, Hui Li, Xiudong Yang, Gang Jin, Yang Zhang
This study was performed to evaluate the cognitive-enhancing effect Flammulina velutipes polysaccharides (FVP) by compatibilizing with ginsenosides on D-galactose-induced Alzheimer's disease (AD) rats. Results of the Morris water maze test suggested that the cognitive ability of AD rats was significantly elevated after combined treatment with FVP and ginsenosides. Moreover, the anti-oxidant effect was also elevated as reflected by the increased levels of superoxide dismutase, catalase, and glutathione peroxidase and decreased levels of malondialdehyde in the combination group...
February 8, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29425049/polysaccharide-sub-microcarrier-for-improved-pulmonary-delivery-of-poorly-soluble-anti-infective-ciprofloxacin-preparation-characterization-and-influence-of-size-on-cellular-uptake
#14
Duy-Khiet Ho, Ana Costa, Chiara De Rossi, Cristiane de Souza Carvalho-Wodarz, Brigitta Loretz, Claus-Michael Lehr
The majority of the currently used and developed anti-infectives are poorly water-soluble molecules. The poor solubility might lead to limited bioavailability and pharmacological action of the drug. Novel pharmaceutical materials have thus been designed to solve those problems and improve drug delivery. In this study, we propose a facile method to produce sub-microcarriers (sMCs) by electrostatic gelation of anionic ß-Cyclodextrin (aß-CD) and chitosan. The average hydrodynamic size ranged from 400-900 nm by carefully adjusting polymer concentrations and N/C ratio...
February 9, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29423317/design-and-production-of-conjugate-vaccines-against-s-paratyphi-a-using-an-o-linked-glycosylation-system-in-vivo
#15
Peng Sun, Chao Pan, Ming Zeng, Bo Liu, Haoyu Liang, Dongshu Wang, Xiankai Liu, Bin Wang, Yufei Lyu, Jun Wu, Li Zhu, Hengliang Wang
Enteric fever, mainly caused by Salmonella enterica serovar Paratyphi A, remains a common and serious infectious disease worldwide. As yet, there are no licensed vaccines against S. Paratyphi A. Biosynthesis of conjugate vaccines has become a promising approach against bacterial infection. However, the popular biosynthetic strategy using N-linked glycosylation systems does not recognize the specialized O-polysaccharide structure of S. Paratyphi A. Here, we describe an O-linked glycosylation approach, the only currently available glycosylation system suitable for an S...
2018: NPJ Vaccines
https://www.readbyqxmd.com/read/29422338/linear-%C3%AE-1%C3%A2-%C3%A2-%C3%A2-6-d-glucan-from-bifidobacterium-bifidum-bim-%C3%B0-733d-is-low-molecular-mass-biopolymer-with-unique-immunochemical-properties
#16
Elena P Kiseleva, Konstantin I Mikhailopulo, Evelina L Zdorovenko, Yuriy A Knirel, Galina I Novik
Role of microorganisms in induction of/protection from autoimmune diseases is proven though molecular mechanisms and bacterial/viral/yeast biopolymers responsible for these effects are in the research stage. Autoantobodies (AAbs) to thyroid peroxidase (anti-TPO) and thyroglobulin (anti-Tg) as well as AAbs to transglutaminase 2 (anti-TG2) and antibodies to gliadins (anti-gliadins) are serological markers of autoimmune thyroid disease and celiac disease, respectively, and players in pathogenesis of these autoimmune diseases...
December 20, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/29421063/targeted-delivery-of-snx-2112-by-polysaccharide-modified-graphene-oxide-nanocomposites-for-treatment-of-lung-cancer
#17
Xuan Liu, Xiaozhen Cheng, Fengzhe Wang, Longbao Feng, Yu Wang, Yanfang Zheng, Rui Guo
Graphene oxide (GO) is a promising material for biomedical applications, particularly in drug delivery, due to its exceptional chemical and physical properties. In this work, an innovative GO-based carrier was developed by modifying GO with chitosan (CHI) to improve the biocompatibility, and followed by the conjugation of hyaluronic acid (HA), the target ligand for CD44, to realize the specific recognition of tumor cells and improve the efficiency of anti-tumor drug delivery. The resulting product GO-CHI-HA was loaded with an anti-cancer drug SNX-2112, which is the Hsp90 inhibitor...
April 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29421058/structural-comparison-antioxidant-and-anti-inflammatory-properties-of-fucosylated-chondroitin-sulfate-of-three-edible-sea-cucumbers
#18
Jiaojiao Mou, Qiang Li, Xiaohui Qi, Jie Yang
Three fucosylated chondroitin sulfate (fCS) were obtained from edible sea cucumbers Apostichopus japonicus, Stichopus chloronotus and Acaudina molpadioidea collected from China. fCS from Stichopus chloronotus was firstly reported. The detailed structures of fCSs, particularly the fucose branches, were investigated and compared. 1H and 13C NMR of the polysaccharide identified three sulfation patterns of fucose branches: 4-O-, 2,4-di-O, and 3,4-di-O-sulfation variously existed in different fCSs. The backbone structure was confirmed by the monosaccharide composition and two-dimensional NMR...
April 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29421053/therapeutic-roles-of-polysaccharides-from-dendrobium-officinaleon-colitis-and-its-underlying-mechanisms
#19
Jian Liang, Shuxian Chen, Jianhui Chen, Jizong Lin, Qingping Xiong, Yiqi Yang, Jun Yuan, Lian Zhou, Lian He, Shaozhen Hou, Shijie Li, Song Huang, Xiaoping Lai
Polysaccharide, as a promising candidate to meet the medication requirement of ulcerative colitis (UC), is increasingly attracting extensive interest. Dendrobium officinale has been widely used to treat gastrointestinal sickness in the clinical treatment of Traditional Chinese Medicine. However, it remains largely unknown whether polysaccharides (DOPS) from Dendrobium officinale can treat UC. The purpose of this paper is to confirm therapeutic action of DOPS to UC and explored its underlying mechanisms. We noted that DOPS could dramatically improve clinical signs and symptoms, decrease mortality, alleviate colonic pathological damage, and reestablish the balance of pro- and anti-inflammatory cytokines in DSS-induced acute UC mice...
April 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29421049/optimized-extraction-of-pectin-like-polysaccharide-from-suaeda-fruticosa-leaves-characterization-antioxidant-anti-inflammatory-and-analgesic-activities
#20
Zeineb Mzoughi, Amal Abdelhamid, Christophe Rihouey, Didier Le Cerf, Abderrahman Bouraoui, Hatem Majdoub
Box-Behnken design (BBD) was performed via ultrasound-assisted system to optimize extraction yield and total antioxidant ability of polysaccharides from Suaeda fruticosa. Three independent variables were studied: temperature, time and pH with optimal settings 90 °C, 37 min and 2.9, respectively. Under these settings, isolation yield and total antioxidant activity were 34.0% and 31.8 mg ascorbic acid equivalent/g material, respectively. Furthermore, preliminary structure study was carried out using UV-vis analysis, Fourier transform infrared spectroscopy (FT-IR) and Nuclear magnetic resonance (1D (1H, 13C NMR) and 2D (1H, 1H COSY, 1H/13C HSQC)) methods Size exclusion chromatography (SEC) determination revealed that polysaccharide extracted had an average molecular weight of 240 kDa...
April 1, 2018: Carbohydrate Polymers
keyword
keyword
52137
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"