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https://www.readbyqxmd.com/read/29769493/immune-response-against-hepatitis-b-virus-after-pentavalent-vaccination-in-children
#1
R Karim, M S Rahman, M S Uddin
This study was done to know the real status of immune response to Hepatitis B vaccine among the pentavalent vaccinated children as per EPI schedule of Bangladesh. It was prospective observational study done in the EPI corner of Paediatric OPD of Dhaka National Medical College & Hospital (DNMCH), Dhaka from July 2015 to July 2016. Sixty (60) children ranging from 9 months to 2 years of age, who received pentavalent vaccination (Hepatitis B + DPT + Hib) according to EPI schedule, were included. The testing for anti-HBs titres were conducted in the Department of Virology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29761850/unexpected-regulation-pattern-of-the-ikk%C3%AE-nf-%C3%AE%C2%BAb-murf1-pathway-with-remarkable-muscle-plasticity-in-the-daurian-ground-squirrel-spermophilus-dauricus
#2
Yanhong Wei, Lingchen Gong, Weiwei Fu, Shenhui Xu, Zhe Wang, Jie Zhang, Er Ning, Hui Chang, Huiping Wang, Yunfang Gao
As a typical hibernator, the Daurian ground squirrel (Spermophilus dauricus) spends considerable time in a state of reduced activity with prolonged fasting. Despite this, they experience little muscle atrophy and have thus become an interesting anti-disuse muscle atrophy model. The IKKβ/NF-κB signaling pathway is significant to muscle atrophy due to the protein degradation resulting from the upregulation of the E3 ubiquitin ligase MuRF1. The current study showed that the IKKβ/NF-κB signaling pathway and MuRF1 maintained relatively steady mRNA and protein expression levels, with little muscle atrophy observed in the soleus (slow-twitch, SOL) or extensor digitorum longus (fast-twitch, EDL) during hibernation (HIB); however, mRNA expression significantly increased in the SOL and EDL muscle during interbout arousal (IBA), as did the MuRF1 mRNA level in the SOL and MuRF1 protein level in the EDL...
May 15, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29685594/safety-tolerability-and-immunogenicity-of-intramuscular-administration-of-prp-crm-197-hib-vaccine-to-healthy-japanese-children-an-open-label-trial
#3
Takehiro Togashi, Nodoka Mitsuya, Shuji Sumino, Yohei Takanami
BACKGROUND: Japan licensed the conjugate Haemophilus influenzae type b vaccine, Vaxem™ Hib, based on clinical studies using subcutaneous injection. The present study was performed to ensure this vaccine is suitable for intramuscular injection in Japanese children. METHODS: Thirty-one healthy 2-6-month-old infants received three doses of Vaxem™ Hib by intramuscular injection at 4-week intervals and a booster dose 1 year later, concomitant with routine infant (DTaP-IPV and pneumococcal) and toddler (measles-rubella) vaccines...
May 17, 2018: Vaccine
https://www.readbyqxmd.com/read/29675174/a-modular-synthetic-route-to-size-defined-immunogenic-haemophilus-influenzae-b-antigens-is-key-to-the-identification-of-an-octasaccharide-lead-vaccine-candidate
#4
J Y Baek, A Geissner, D C K Rathwell, D Meierhofer, C L Pereira, P H Seeberger
The first glycoconjugate vaccine using isolated glycans was licensed to protect children from Haemophilus influenzae serotype b (Hib) infections. Subsequently, the first semisynthetic glycoconjugate vaccine using a mixture of antigens derived by polymerization targeted the same pathogen. Still, a detailed understanding concerning the correlation between oligosaccharide chain length and the immune response towards the polyribosyl-ribitol-phosphate (PRP) capsular polysaccharide that surrounds Hib remains elusive...
February 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29459064/comparison-of-serum-bactericidal-and-antibody-titers-induced-by-two-haemophilus-influenzae-type-b-conjugate-vaccines-a-phase-iii-randomized-double-blind-study
#5
Yukihiro Akeda, Yuka Koizumi, Yohei Takanami, Shuji Sumino, Yumi Hattori, Kayoko Sugizaki, Nodoka Mitsuya, Kazunori Oishi
Haemophilus influenzae type b (Hib) conjugate vaccines have drastically reduced disease incidence worldwide. Protection against Hib infection has relied on the serum bactericidal activity (SBA) of antibodies to the Hib capsular polysaccharide (polyribosylribitol phosphate). However, licensure usually relies on measuring induction of antibodies to PRP as a surrogate for SBA. In a phase III clinical trial we compared a PRP-conjugate vaccine using the nontoxic diphtheria toxin mutant, CRM197 , as carrier protein with the licensed tetanus toxoid conjugate when administered subcutaneously as a three dose primary series in Japanese infants...
March 14, 2018: Vaccine
https://www.readbyqxmd.com/read/29432383/safety-and-immunogenicity-of-seven-dosing-regimens-of-the-candidate-rts-s-as01e-malaria-vaccine-integrated-within-an-expanded-program-on-immunization-regimen-a-phase-ii-single-center-open-controlled-trial-in-infants-in-malawi
#6
Desiree Witte, Nigel A Cunliffe, Ann M Turner, Edward Ngulube, Opokua Ofori-Anyinam, Johan Vekemans, Philips Chimpeni, Marc Lievens, Trevor P Wilson, Jenala Njiram'madzi, Yolanda Guerra Mendoza, Amanda Leach
BACKGROUND: In a phase III trial, the RTS,S/AS01 malaria vaccine produced lower anti-circumsporozoite (CS) antibody titers when co-administered with Expanded Programme on Immunization vaccines (0-, 1- and 2-month schedule) at 6 to 12 weeks compared with 5 to 17 months at first vaccination. Alternative infant immunization schedules within the Expanded Programme on Immunization were investigated. METHODS: This phase II, open, single-site (Blantyre, Malawi) trial was conducted in infants 1 to 7 days of age...
May 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29428913/anti-hbs-titers-following-pentavalent-immunization-dtwp-hbv-hib-in-term-normal-weight-vs-low-birth-weight-infants
#7
Chandrika Verma, M M A Faridi, Manish Narang, Iqbal R Kaur
OBJECTIVE: To compare anti HBs titers between term low birth weight (1800-2499 g) infants and normal birth weight infants, 6 weeks after last dose of primary immunization with pentavalent vaccine, and to study adverse events following immunization (AEFI) with pentavalent vaccine. DESIGN: Cohort study. SETTING: Tertiary-care hospital predominantly catering to urban poor population of East Delhi. PARTICIPANTS: 265 low birth weight (1800-2499 g) and 265 normal birth weight (2500-4000 g) infants Monovalent Hepatitis B vaccine was administered within 24 hours of birth followed by three primary doses of pentavalent vaccine at 6, 10 and 14 weeks...
February 9, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29390149/cord-blood-antiparasite-interleukin-10-as-a-risk-marker-for-compromised-vaccine-immunogenicity-in-early-childhood
#8
Indu Malhotra, A Desiree LaBeaud, Nathan Morris, Maxim McKibben, Peter Mungai, Eric Muchiri, Christopher L King, Charles H King
Background: Antenatal exposure to parasites can affect infants' subsequent responses to vaccination. The present study investigated how maternal prenatal infections and newborns' antiparasite cytokine profiles relate to immunoglobulin G (IgG) responses to standard vaccination during infancy. Methods: A total of 450 Kenyan women were tested for parasitic infections during pregnancy. Their newborns' responses to Plasmodium falciparum, schistosome, and filaria antigens were assessed in cord blood lymphocytes...
April 11, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29289561/haemophilus-influenzae-type-b-hib-seroprevalence-and-current-epidemiology-in-england-and-wales
#9
Sarah Collins, David Litt, Rachael Almond, Jamie Findlow, Ezra Linley, Mary Ramsay, Ray Borrow, Shamez Ladhani
INTRODUCTION: The implementation of the Hib conjugate vaccine in the United Kingdom in 1992 resulted in a rapid decline in invasive Hib disease across all age groups. However, a resurgence in 2000-2002 prompted the introduction of additional control measures, including a routine 12-month booster in 2006. Here we describe results from a national serosurvey in children eligible for the 12-month booster and recent Haemophilus influenzae epidemiology in England and Wales. METHODS: A national serosurvey was performed to determine the prevalence of anti-polyribosyl-phosphate (anti-PRP) IgG antibodies in 1000 residual samples from children up to 8 years of age in 2013-2014...
April 2018: Journal of Infection
https://www.readbyqxmd.com/read/29277353/immunologic-non-inferiority-and-safety-of-the-investigational-pneumococcal-non-typeable-haemophilus-influenzae-protein-d-conjugate-vaccine-phid-cv-4-dose-vial-presentation-compared-to-the-licensed-phid-cv-1-dose-vial-presentation-in-infants-a-phase-iii-randomized
#10
Khalequ Zaman, Sheikh Farzana Zaman, Farzana Zaman, Asma Aziz, Sayeed-Bin Faisal, Magali Traskine, Md Ahsan Habib, Javier Ruiz-Guiñazú, Dorota Borys
BACKGROUND: To support vaccination programs in developing countries, a 4-dose vial presentation of pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) was developed. This study assessed immunologic non-inferiority and safety of the investigational PHiD-CV 4-dose versus licensed 1-dose vial presentation in infants. METHODS: In this phase III, mono-center, observer-blind study in Bangladesh, 6-10-week-old infants were randomized 1:1 to receive PHiD-CV primary vaccination (at ages 6, 10, 18 weeks) and a booster dose (at age 9 months) with a 4-dose vial (with preservative, 4DV group) or 1-dose vial (preservative-free, 1DV group)...
January 29, 2018: Vaccine
https://www.readbyqxmd.com/read/29054729/hib-antibody-responses-in-infants-following-diphtheria-tetanus-acellular-pertussis-and-conjugated-haemophilus-influenzae-type-b-hib-combination-vaccines-with-decreasing-amounts-of-tetanus-toxoid
#11
Henry H Bernstein, Elisabeth R Seyferth
BACKGROUND: While combination vaccines have contributed to improved vaccine uptake rates in children, studies have documented varied immunogenicity to specific vaccine components. We studied whether varying the amount of tetanus toxoid (TT) in a DTaP and Hib combination vaccine would result in immunogenicity comparable with separate, concurrent administration. METHODS: We evaluated the immunogenicity of Massachusetts Biologic Laboratories (MBL) diphtheria, tetanus, and acellular pertussis (mDTaP) vaccine combined with tetanus-conjugated MBL Haemophilus influenzae type b vaccine (mHib) in a single injection (DTaPH)...
December 4, 2017: Vaccine
https://www.readbyqxmd.com/read/28959067/hepatitis-b-virus-surface-antigen-and-antibody-markers-in-children-at-a-major-paediatric-hospital-after-the-pentavalent-dtp-hbv-hib-vaccination
#12
Thomas Apiung, Thomas A Ndanu, Julius Aa Mingle, Kwamena Wc Sagoe
OBJECTIVES: The knowledge about outcomes of infant vaccination against HBV infections using the DPT-HepB-Hib vaccine in Ghana is limited. This study therefore investigated the levels of immunity to HBV among children who received the DPT-HepB-Hib vaccine and HBsAg carriage in non-responders. Correlates for non-response or poor response were also investigated. METHODS: Cross-sectional study. A major paediatric hospital in Accra. Four hundred and twenty four children between the ages of 5 to 32 months who had completed the full vaccination schedule for the DPT-HepB-Hib vaccine...
March 2017: Ghana Medical Journal
https://www.readbyqxmd.com/read/28729019/safety-reactogenicity-and-immunogenicity-of-two-investigational-pneumococcal-protein-based-vaccines-results-from-a-randomized-phase-ii-study-in-infants
#13
RANDOMIZED CONTROLLED TRIAL
Roman Prymula, Leszek Szenborn, Sven-Arne Silfverdal, Jacek Wysocki, Piotr Albrecht, Magali Traskine, Asparuh Gardev, Yue Song, Dorota Borys
INTRODUCTION: Vaccination with formulations containing pneumococcal protein antigens such as pneumolysin toxoid (dPly) and histidine-triad protein D (PhtD) may extend serotype-related protection of pneumococcal conjugate vaccines (PCVs) against Streptococcus pneumoniae. METHODS: This phase II, multi-center, observer-blind trial conducted in Europe (NCT01204658) assessed 2 investigational vaccines containing 10 serotype-specific polysaccharide conjugates of PHiD-CV and either 10 or 30µg of dPly and PhtD each...
August 16, 2017: Vaccine
https://www.readbyqxmd.com/read/28536030/lot-to-lot-consistency-safety-and-immunogenicity-of-3-lots-of-haemophilus-influenzae-type-b-conjugate-vaccine-results-from-a-phase-iii-randomized-multicenter-study-in-infants
#14
RANDOMIZED CONTROLLED TRIAL
Nicola P Klein, Remon Abu-Elyazeed, Matthew Cornish, Michael L Leonardi, Leonard B Weiner, Peter E Silas, Stanley E Grogg, Meera Varman, Robert W Frenck, Brigitte Cheuvart, Yaela Baine, Jacqueline M Miller, Maarten Leyssen, Narcisa Mesaros, Sumita Roy-Ghanta
BACKGROUND: Vaccination against Haemophilus influenzae type b (Hib) is included in routine pediatric immunization schedule in the United States. Previous vaccine shortages have created the need for additional options for Hib vaccination. METHODS: This phase III, randomized, multi-centered study (NCT01000974) evaluated the safety and immunogenicity of a monovalent tetanus toxoid-conjugate Hib vaccine (Hib-TT) compared to a monovalent (Hib-TT control) and a combination Hib-TT vaccine...
June 16, 2017: Vaccine
https://www.readbyqxmd.com/read/28536027/live-attenuated-tetravalent-g1-g4-bovine-human-reassortant-rotavirus-vaccine-brv-tv-randomized-controlled-phase-iii-study-in-indian-infants
#15
RANDOMIZED CONTROLLED TRIAL
Tarun Saluja, Sonali Palkar, Puneet Misra, Madhu Gupta, Potula Venugopal, Ashwani Kumar Sood, Ravi Mandyam Dhati, Avinash Shetty, Sangappa Malappa Dhaded, Sharad Agarkhedkar, Amlan Choudhury, Ramesh Kumar, Sundaram Balasubramanian, Sudhir Babji, Lopa Adhikary, Martin Dupuy, Sangeet Mohan Chadha, Forum Desai, Darshna Kukian, Badri Narayan Patnaik, Mandeep Singh Dhingra
BACKGROUND: Rotavirus remains the leading cause of diarrhoea among children <5years. We assessed immunogenic non-inferiority of a tetravalent bovine-human reassortant rotavirus vaccine (BRV-TV) over the licensed human-bovine pentavalent rotavirus vaccine RV5. METHODS: Phase III single-blind study (parents blinded) in healthy infants randomized (1:1) to receive three doses of BRV-TV or RV5 at 6-8, 10-12, and 14-16weeks of age. All concomitantly received a licensed diphtheria, tetanus, pertussis, hepatitis B, Haemophilus influenzae type b conjugate vaccine (DTwP-HepB-Hib) and oral polio vaccine (OPV)...
June 16, 2017: Vaccine
https://www.readbyqxmd.com/read/28449972/effect-of-prophylactic-or-therapeutic-administration-of-paracetamol-on-immune-response-to-dtwp-hepb-hib-combination-vaccine-in-indian-infants
#16
Arijit Sil, Mandyam D Ravi, Badri N Patnaik, Mandeep S Dhingra, Martin Dupuy, Dulari J Gandhi, Sangappa M Dhaded, Anand P Dubey, Ritabrata Kundu, Sanjay K Lalwani, Jugesh Chhatwal, Leni G Mathew, Madhu Gupta, Shiv D Sharma, Sandeep B Bavdekar, Soumya P Rout, Midde V Jayanth, Naveena A D'Cor, Somnath A Mangarule, Suresh Ravinuthala, Jagadeesh Reddy E
BACKGROUND: Vaccination is considered as the most cost effective method for preventing infectious diseases. Low grade fever is a known adverse effect of vaccination. In India, it is a common clinical practice to prescribe paracetamol either prophylactically or therapeutically to manage fever. Some studies have shown that paracetamol interferes with antibody responses following immunization. This manuscript reports the outcome of a post hoc analysis of data from a clinical trial of a pentavalent vaccine in Indian infants where paracetamol was not used or was used either as prophylaxis or for treatment of fever...
May 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28340322/immunogenicity-and-safety-of-primary-and-booster-vaccination-with-2-investigational-formulations-of-diphtheria-tetanus-and-haemophilus-influenzae-type-b-antigens-in-a-hexavalent-dtpa-hbv-ipv-hib-combination-vaccine-in-comparison-with-the-licensed-infanrix-hexa
#17
RANDOMIZED CONTROLLED TRIAL
Timo Vesikari, Luis Rivera, Tiina Korhonen, Anitta Ahonen, Brigitte Cheuvart, Marjan Hezareh, Winnie Janssens, Narcisa Mesaros
Safety and immunogenicity of 2 investigational formulations of diphtheria, tetanus and Haemophilus influenzae type b antigens of the combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliomyelitis-Hib vaccine (DTPa-HBV-IPV/Hib) were evaluated in a Primary (NCT01248884) and a Booster vaccination (NCT01453998) study. In the Primary study, 721 healthy infants (randomized 1:1:1) received 3 doses of DTPa-HBV-IPV/Hib formulation A (DA TA Pa-HBV-IPV/Hib), or B (DB TB Pa-HBV-IPV/Hib) or the licensed DTPa-HBV-IPV/Hib vaccine (Infanrix hexa, GSK; control group) at 2, 3, 4 months of age...
July 3, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28277801/the-immunogenicity-and-safety-of-a-hib-menac-vaccine-a-non-inferiority-randomized-observer-blind-trial-in-infants-aged-3-5-months
#18
RANDOMIZED CONTROLLED TRIAL
Yu-Xiao Wang, Hong Tao, Jian-Li Hu, Jing-Xin Li, Wei-Ming Dai, Jin-Fang Sun, Pei Liu, Jie Tang, Wen-Yu Liu, Feng-Cai Zhu
BACKGROUND: The objective of this study was to evaluate the immunogenicity and safety of the novel combined Haemophilus influenzae type b-Neisseria meningitidis serogroup A and C-tetanus toxoid conjugate vaccine (Hib-MenAC). METHODS: We conducted a non-inferiority, randomized, observer-blind, positive control clinical trial in 900 healthy infants aged between 3-5 months in Funing County, Jiangsu Province, China. Participants were randomly allocated, in a ratio of 2:1 (block = 6), to receive experimental combined Hib-MenAC vaccines co-administrated with placebo or the co-administration of licensed Hib vaccine and MenAC vaccine, according to a three-dose immunization schedule...
May 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27939054/concomitant-administration-of-a-fully-liquid-ready-to-use-dtap-ipv-hb-prp-t-hexavalent-vaccine-with-a-meningococcal-serogroup-c-conjugate-vaccine-in-infants
#19
RANDOMIZED CONTROLLED TRIAL
Timo Vesikari, Ray Borrow, Xavier Da Costa, Patrick Richard, Cécile Eymin, Florence Boisnard, Stephen Lockhart
DTaP-IPV-HB-PRP-T or hexavalent vaccines are indicated for primary and booster vaccination of infants and toddlers against diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis and invasive diseases caused by Haemophilus influenzae type b (Hib). The present study evaluates the safety and immunogenicity of a ready-to-use hexavalent vaccine when co-administered with a meningococcal serogroup C conjugate (MenC) vaccine in infants. This was a phase III, open-label, randomised, multicentre study conducted in Finland...
January 11, 2017: Vaccine
https://www.readbyqxmd.com/read/27833050/eicosapentaenoic-acid-regulates-brown-adipose-tissue-metabolism-in-high-fat-fed-mice-and-in-clonal-brown-adipocytes
#20
Mandana Pahlavani, Fitia Razafimanjato, Latha Ramalingam, Nishan S Kalupahana, Hanna Moussa, Shane Scoggin, Naima Moustaid-Moussa
Brown adipose tissue (BAT) plays a key role in energy expenditure through its specialized thermogenic function. Therefore, BAT activation may help prevent and/or treat obesity. Interestingly, subcutaneous white adipose tissue (WAT) also has the ability to differentiate into brown-like adipocytes and may potentially contribute to increased thermogenesis. We have previously reported that eicosapentaenoic acid (EPA) reduces high-fat (HF)-diet-induced obesity and insulin resistance in mice. Whether BAT mediates some of these beneficial effects of EPA has not been determined...
January 2017: Journal of Nutritional Biochemistry
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