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https://www.readbyqxmd.com/read/29017702/collaborative-study-on-saccharide-quantification-of-the-haemophilus-influenzae-type-b-component-in-liquid-vaccine-presentations
#1
U Rosskopf, A Daas, E Terao, C von Hunolstein
Before release onto the market, it must be demonstrated that the total and free polysaccharide (poly ribosyl-ribitol-phosphate, PRP) content of Haemophilus influenzae type b (Hib) vaccine complies with requirements. However, manufacturers use different methods to assay PRP content: a national control laboratory must establish and validate the relevant manufacturer methodology before using it to determine PRP content. An international study was organised by the World Health Organization (WHO), in collaboration with the Biological Standardisation Programme (BSP) of the Council of Europe/European Directorate for the Quality of Medicines & HealthCare (EDQM) and of the European Union Commission, to verify the suitability of a single method for determining PRP content in liquid pentavalent vaccines (DTwP-HepB-Hib) containing a whole-cell pertussis component...
2017: Pharmeuropa Bio & Scientific Notes
https://www.readbyqxmd.com/read/28988865/impact-of-haemophilus-influenzae-type-b-conjugate-vaccination-on-hospitalization-for-invasive-disease-in-children-fifteen-years-after-its-introduction-in-italy
#2
Domenico Martinelli, Chiara Azzari, Paolo Bonanni, Susanna Esposito, Elisabetta Franco, Giancarlo Icardi, Gianvincenzo Zuccotti, Rosa Prato
In Italy, Hib conjugate vaccine was introduced for infants in 1999 and included in the DTaP-HBV-IPV-Hib combination in 2001, with an uptake of 83.4% in 2002, >90% by 2005, and >95% by 2011. We estimated the impact of Hib vaccination on hospitalizations for H. influenzae invasive disease in children <5years. Age-specific hospitalization rates and hospitalization risk ratios (HRRs) with 95%CI during 2001-2013 were calculated performing time-series analysis. The number of cases reported to the national surveillance of invasive bacterial diseases was compared to the number of hospitalizations between 2007-2013...
October 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28987442/haemophilus-influenzae-type-b-carriage-and-burden-of-its-related-diseases-in-chinese-children-systematic-review-and-meta-analysis
#3
REVIEW
Ya Yang, Xiang Pan, Wanting Cheng, Yu Yang, Robert W Scherpbier, Xu Zhu, Yue Chen, Yibiao Zhou, Qingwu Jiang
BACKGROUND: Haemophilus influenzae type b (Hib) is an important cause of invasive bacterial disease in children worldwide. The limited awareness of disease burden is a major barrier to the introduction of Hib vaccine into China's National Immunization Program. Therefore, we conducted a systematic review and meta-analysis to estimate carriage of Hib and burden of its related diseases in Chinese children. METHODS: We systematically searched Pubmed, Web of Science, Ovid, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases for studies published up to December 31, 2016, reporting Hib carriage and burden of Hib diseases among children in Mainland China...
October 4, 2017: Vaccine
https://www.readbyqxmd.com/read/28983392/effects-of-polio-eradication-activities-on-routine-immunization-lessons-from-the-2013-outbreak-response-in-somali-region-of-ethiopia
#4
Belete Tafesse, Ephrem Tekle, Liya Wondwossen, Mengistu Bogale, Braka Fiona, Peter Nsubuga, Karengera Tomas, Aron Kassahun, Gallagher Kathleen, Aschalew Teka
INTRODUCTION: Ethiopia experienced several WPV importations with a total of 10 WPV1 cases confirmed during the 2013 outbreak alone before it is closed in 2015. We evaluated supplemental immunization activities (SIAs), including lessons learned for their effect on the routine immunization program during the 2013 polio outbreak in Somali regional state. METHODS: We used descriptive study to review documents and analyse routine health information system reports from the polio outbreak affected Somali regional state...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28983390/behavioral-determinants-of-immunization-service-utilization-in-ethiopia-a-cross-sectional-community-based-survey
#5
Yohannes Ababu, Fiona Braka, Aschalew Teka, Kinde Getachew, Tefera Tadesse, Yohannes Michael, Zewdie Birhanu, Peter Nsubuga, Tersit Assefa, Kathleen Gallagher
INTRODUCTION: According to the Ethiopian Health Sector Development Plan IV annual performance report (HSDP IV), Ethiopia targeted to reach 90% coverage with DPT-Hib-HepB 3 (Pentavalent3) vaccine and 86% coverage with measles vaccine in 2010- 2011. However, the actual performance fell-short of the intended targets due to several reasons. Therefore, a nationwide comprehensive study was conducted to examine the behavioral determinants of immunization practices in the Ethiopian context. The study employed the Modified Steps of Behavioral Change (SBC) Model as a theoretical lens...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28971707/a-review-of-haemophilus-influenzae-disease-in-europe-from-2000-2014-challenges-successes-and-the-contribution-of-hexavalent-combination-vaccines
#6
Shuchen Wang, Monica Tafalla, Linda Hanssens, Jan Dolhain
The development of diphtheria-tetanus-acellular pertussis-Haemophilus influenzae type b (Hib) conjugate vaccine combinations culminated with hexavalent vaccines, the largest, most complex vaccine combinations in the immunization calendar. Hexavalent vaccines are used widely in Europe and are co-administered with multiple other recommended vaccines. Hib immunogenicity may reduce when combined with acellular pertussis antigens, or in some co-administrations. We reviewed the epidemiology of H. influenzae disease in Europe aiming to evaluate the current level of Hib control and indirectly assess the effectiveness against Hib of GSK's hexavalent vaccine in 10 countries where it is/has been used almost exclusively...
October 3, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28967446/-production-of-infectious-units-of-isaria-fumosorosea-hypocreales-cordycipitaceae-from-different-indigenous-isolates-of-northeastern-mexico-using-3-propagation-strategies
#7
Fatima L Gandarilla-Pacheco, Lilia H Morales-Ramos, Benito Pereyra-Alférez, Myriam Elías-Santos, Isela Quintero-Zapata
The aim of this study was to evaluate the production of blastospores and conidia of different native isolates and a strain of Isaria fumosorosea using different propagation techniques. Two liquid culture media of casamino acids and peptone as nitrogen sources and glucose as carbon source for both media cultures were respectively used in the production of blastospores, while for the production of conidia, the fungi were grown in potato dextrose agar; from these cultures, solutions of conidia to a concentration of 1×10(6) per milliliter were prepared to inoculate flasks with Sabouraud dextrose broth for the liquid phase of the biphasic culture, also known as preculture...
September 26, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28959067/hepatitis-b-virus-surface-antigen-and-antibody-markers-in-children-at-a-major-paediatric-hospital-after-the-pentavalent-dtp-hbv-hib-vaccination
#8
Thomas Apiung, Thomas A Ndanu, Julius Aa Mingle, Kwamena Wc Sagoe
OBJECTIVES: The knowledge about outcomes of infant vaccination against HBV infections using the DPT-HepB-Hib vaccine in Ghana is limited. This study therefore investigated the levels of immunity to HBV among children who received the DPT-HepB-Hib vaccine and HBsAg carriage in non-responders. Correlates for non-response or poor response were also investigated. METHODS: Cross-sectional study. A major paediatric hospital in Accra. Four hundred and twenty four children between the ages of 5 to 32 months who had completed the full vaccination schedule for the DPT-HepB-Hib vaccine...
March 2017: Ghana Medical Journal
https://www.readbyqxmd.com/read/28958691/branched-chain-amino-acid-catabolism-rather-than-amino-acids-plasma-concentrations-is-associated-with-diet-induced-changes-in-insulin-resistance-in-overweight-to-obese-individuals
#9
S Haufe, S Engeli, J Kaminski, H Witt, D Rein, B Kamlage, W Utz, J C Fuhrmann, V Haas, A Mähler, J Schulz-Menger, F C Luft, M Boschmann, J Jordan
BACKGROUND & AIMS: 3-Hydroxyisobutyrate (3-HIB), a catabolic intermediate of the BCAA valine, which stimulates muscle fatty acid uptake, has been implicated in the pathogenesis of insulin resistance. We tested the hypothesis that circulating 3-HIB herald insulin resistance and that metabolic improvement with weight loss are related to changes in BCAAs and 3-HIB. METHODS AND RESULTS: We analyzed plasma and urine in 109 overweight to obese individuals before and after six months on hypocaloric diets reduced in either carbohydrates or fat...
October 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28951105/epidemiology-of-invasive-pneumococcal-and-haemophilus-influenzae-diseases-in-northwestern-ontario-canada-2010-2015
#10
Vic Eton, Annette Schroeter, Len Kelly, Michael Kirlew, Raymond S W Tsang, Marina Ulanova
INTRODUCTION: North American Indigenous populations experience a high burden of invasive bacterial infections. Because Streptococcus pneumoniae and Haemophilus influenzae (Hi) have multiple antigenic variants, the existing vaccines cannot prevent all cases. This study addresses current epidemiology of invasive Hi and pneumococcal disease (IPD) in a region of Northwestern Ontario, Canada with a relatively high (82%) Indigenous population. METHODS: Data were retrieved from retrospective chart review at a hospital servicing a population of 29,000 (82% Indigenous), during January 2010-July 2015...
September 22, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28910095/signature-of-metallic-behavior-in-the-metal-organic-frameworks-m3-hexaiminobenzene-2-m-ni-cu
#11
Jin-Hu Dou, Lei Sun, Yicong Ge, Wenbin Li, Christopher H Hendon, Ju Li, Sheraz Gul, Junko Yano, Eric A Stach, Mircea Dincă
The two-dimensionally connected metal-organic frameworks (MOFs) Ni3(HIB)2 and Cu3(HIB)2 (HIB = hexaiminobenzene) are bulk electrical conductors and exhibit ultraviolet-photoelectron spectroscopy (UPS) signatures expected of metallic solids. Electronic band structure calculations confirm that in both materials the Fermi energy lies in a partially filled delocalized band. Together with additional structural characterization and microscopy data, these results represent the first report of metallic behavior and permanent porosity coexisting within a metal-organic framework...
September 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28903749/modelling-the-effects-of-booster-dose-vaccination-schedules-and-recommendations-for-public-health-immunization-programs-the-case-of-haemophilus-influenzae-serotype-b
#12
Nadia A Charania, Seyed M Moghadas
BACKGROUND: Haemophilus influenzae serotype b (Hib) has yet to be eliminated despite the implementation of routine infant immunization programs. There is no consensus regarding the number of primary vaccine doses and an optimal schedule for the booster dose. We sought to evaluate the effect of a booster dose after receiving the primary series on the long-term disease incidence. METHODS: A stochastic model of Hib transmission dynamics was constructed to compare the long-term impact of a booster vaccination and different booster schedules after receiving the primary series on the incidence of carriage and symptomatic disease...
September 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28887318/ubcd1-regulates-hedgehog-signaling-by-directly-modulating-ci-ubiquitination-and-processing
#13
Chenyu Pan, Yue Xiong, Xiangdong Lv, Yuanxin Xia, Shuo Zhang, Hao Chen, Jialin Fan, Wenqing Wu, Feng Liu, Hailong Wu, Zhaocai Zhou, Lei Zhang, Yun Zhao
The Hh pathway controls many morphogenetic processes in metazoans and plays important roles in numerous pathologies and in cancer. Hh signaling is mediated by the activity of the Gli/Ci family of transcription factors. Several studies in Drosophila have shown that ubiquitination by the ubiquitin E3 ligases Slimb and Rdx(Hib) plays a crucial role in controlling Ci stability dependent on the levels of Hh signals. If Hh levels are low, Slimb adds K11- and K48-linked poly-ubiquitin chains on Ci resulting in partial degradation...
September 8, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28882440/determinants-of-under-immunization-and-cumulative-time-spent-under-immunized-in-a-quebec-cohort
#14
Shauna O'Donnell, Eve Dubé, Bruce Tapiero, Arnaud Gagneur, Margaret K Doll, Caroline Quach
BACKGROUND: Under-immunization refers to a state of sub-optimal protection against vaccine preventable diseases. Vaccine coverage for age may not capture intentional or non-intentional spacing of vaccines in the recommended provincial immunization guidelines. We aimed to identify factors associated with coverage and under-immunization and to determine the number of days during which children were under-immunized during their first 24months of life. METHODS: Secondary analysis of children ≤3years recruited through active surveillance for gastroenteritis from three Quebec pediatric emergency departments from 2012 to 2014...
September 4, 2017: Vaccine
https://www.readbyqxmd.com/read/28871608/paediatric-invasive-haemophilus-influenzae-in-queensland-australia-2002-2011-young-indigenous-children-remain-at-highest-risk
#15
Gavin Cleland, Clare Leung, Jenny Wan Sai Cheong, Joshua Francis, Claire Heney, Clare Nourse
AIM: Haemophilus influenzae continues to cause invasive disease in children despite widespread Hib immunisation. The significance of non-B serotypes continues to be investigated, with evidence of increased invasive non-typeable H. influenzae (NTHi) world-wide. The aim of this study was to examine the current epidemiological and clinical features of invasive H. influenzae disease in children in Queensland, Australia. METHODS: A retrospective review was performed of all cases of invasive H...
September 4, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28870657/use-of-biologic-therapy-by-pregnant-women-with-inflammatory-bowel-disease-does-not-affect-infant-response-to-vaccines
#16
Dawn B Beaulieu, Ashwin N Ananthakrishnan, Christopher Martin, Russell D Cohen, Sunanda V Kane, Uma Mahadevan
BACKGROUND & AIMS: In women with inflammatory bowel diseases (IBD), exposure to immunomodulator or biologic therapy has not been associated with adverse events during pregnancy or outcomes of newborns. We investigated whether exposure of patients to these agents during pregnancy affects serologic responses to vaccines in newborns. METHODS: We collected data from the Pregnancy in IBD and Neonatal Outcomes registry, which records outcomes of pregnant women with diagnosis of IBD receiving care at multiple centers in the United States, from 2007 - 2016...
September 1, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28858039/fulminant-haemophilus-influenzae-type-a-infection-in-a-4-year-old-with-previously-undiagnosed-asplenic-heterotaxy
#17
Andrew Headrick, Erinn O Schmit, David W Kimberlin
The post Hib-vaccine era has resulted in increased cases of invasive, non-Hib, Haemophilus influenzae infections. One of the encapsulated species, type a, displays the most similarity in virulence to type b. Our patient, a fully-vaccinated four-year-old female, with newly diagnosed asplenia in the setting of heterotaxy, had a prolonged hospital course with disseminated Haemophilus influenzae type a infection.
August 26, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28855159/non-specific-effects-of-measles-mumps-and-rubella-mmr-vaccination-in-high-income-setting-population-based-cohort-study-in-the-netherlands
#18
COMPARATIVE STUDY
Susanne M A J Tielemans, Hester E de Melker, Susan J M Hahné, Anna G C Boef, Fiona R M van der Klis, Elisabeth A M Sanders, Marianne A B van der Sande, Mirjam J Knol
Objectives To investigate whether measles, mumps, and rubella (MMR) vaccine has positive non-specific effects in a high income setting and to compare rates of hospital admissions for infections between children aged ≤2 years who received live MMR vaccine and those who received an inactivated vaccine against diphtheria, tetanus, pertussis, polio, and Haemophilus influenzae type b (DTaP-IPV-Hib) as their most recent vaccination.Design Nationwide population based cohort study.Setting In the Netherlands, DTaP-IPV-Hib+pneumococcal vaccination (PCV) is recommended at ages 2, 3, 4, and 11 months and MMR + meningococcal C (MenC) vaccination at age 14 months...
August 30, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28840658/experimental-design-and-metabolic-flux-analysis-tools-to-optimize-industrially-relevant-haemophilus-influenzae-type-b-growth-medium
#19
Mateus Ribeiro da Silva, Carla Andreia Freixo Portela, Silvia Maria Ferreira Albani, Paola Rizzo de Paiva, Martha Massako Tanizaki, Teresa Cristina Zangirolami
Haemophilus influenzae type b (Hib), a Gram-negative capsulated bacterium, is a causative agent of meningitis worldwide. The capsular polysaccharide, a high molecular mass polymer consisting of the repeated units of the polyribosyl-ribitol-phosphate, is considered the main virulence factor and it is used as an antigen to vaccines, conjugated to a carrier protein. The industrial production of the polysaccharide requires the cultivation of Hib in rich medium, which impacts process costs and product recovery. In this study, a central composite rotational experimental design strategy was used to access the influence of key components of culture medium (soy peptone, yeast extract and glucose) on biomass formation and polysaccharide production in shake-flasks...
August 25, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28837564/impact-of-meningitis-on-intelligence-and-development-a-systematic-review-and-meta-analysis
#20
Deborah Christie, Harunor Rashid, Haitham El-Bashir, Faye Sweeney, Tim Shore, Robert Booy, Russell M Viner
BACKGROUND: We undertook a systematic review and meta-analysis to address the question "what is the impact of meningitis on IQ and development." METHODS: Search: conducted using standardized search terms across Medline, PsychInfo and EMBASE to 06/2014. Eligibility: human studies of any infectious aetiology of meningitis reporting IQ or infant developmental age or stage outcomes. Quality: Centre for Evidence Based Medicine, Oxford, quality tools. Analysis: random effects meta-analysis by organism...
2017: PloS One
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