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https://www.readbyqxmd.com/read/29920121/hexavalent-vaccines-increasing-options-for-policy-makers-and-providers-a-review-of-the-data-supporting-interchangeability-substitution-with-vaccines-containing-fewer-antigens-and-mixed-schedules-from-the-same-manufacturer
#1
Jan Dolhain, Winnie Janssens, Narcisa Mesaros, Linda Hanssens, Frederik Fierens
Combination vaccines improve vaccine uptake and open the infant immunization space for additional vaccines. Hexavalent vaccines have been marketed since 2000. Infanrix hexa (combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type b conjugate vaccine, DTPa-HBV-IPV/Hib, GSK) is longest on the market, providing 16 years post-marketing experience. Each DTPa-HBV-IPV/Hib vaccine component is licensed alone and/or in smaller combination vaccines. Programmatic considerations sometimes require an interchange between vaccines due to unavailability, program change or mixed schedules (when the number of required antigens differs across scheduled primary vaccination visits)...
June 19, 2018: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29903376/burden-of-streptococcus-pneumoniae-and-haemophilus-influenzae-type-b-disease-in-children-in-the-era-of-conjugate-vaccines-global-regional-and-national-estimates-for-2000-15
#2
Brian Wahl, Katherine L O'Brien, Adena Greenbaum, Anwesha Majumder, Li Liu, Yue Chu, Ivana Lukšić, Harish Nair, David A McAllister, Harry Campbell, Igor Rudan, Robert Black, Maria Deloria Knoll
BACKGROUND: Pneumococcal conjugate vaccine (PCV) and Haemophilus influenzae type b (Hib) vaccine are now used in most countries. To monitor global and regional progress towards improving child health and to inform national policies for disease prevention and treatment, we prepared global, regional, and national disease burden estimates for these pathogens in children from 2000 to 2015. METHODS: Using WHO and Maternal and Child Epidemiology Estimation collaboration country-specific estimates of pneumonia and meningitis mortality and pneumonia morbidity from 2000 to 2015, we applied pneumococcal and Hib cause-specific proportions to estimate pathogen-specific deaths and cases...
July 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29804542/dtwp-hb-hib-antibody-persistence-after-a-primary-series-immune-response-and-safety-after-a-booster-dose-in-children-18-24-months-old
#3
Hartono Gunardi, Kusnandi Rusmil, Eddy Fadlyana, Soedjatmiko, Meita Dhamayanti, Rini Sekartini, Rodman Tarigan, Hindra Irawan Satari, Bernie Endyarni Medise, Rini Mulia Sari, Novilia Sjafri Bachtiar, Cissy B Kartasasmita, Sri Rezeki S Hadinegoro
BACKGROUND: The new combination of DTwP-HB-Hib vaccines has been developed in Indonesia following World Health Organization (WHO) recommendation and integrated into national immunization program. The aims of the study were to measure 1) antibody persistence 12-18 months after a primary series, 2) immune response and safety after a booster dose of DTwP-HB-Hib. METHODS: This was a multi-center, open-labeled, prospective, interventional study. Subjects who had received complete primary dose of DTwP-HB-Hib vaccine from the previous phase III trial were recruited in this trial...
May 28, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29795077/vaccination-coverage-among-children-aged-2-years-u-s-affiliated-pacific-islands-april-october-2016
#4
Ashley Tippins, Neil Murthy, Mehreen Meghani, Amy Solsman, Carter Apaisam, Merlyn Basilius, Maribeth Eckert, Peter Judicpa, Yolanda Masunu, Kelsey Pistotnik, Daisy Pedro, Jeremy Sasamoto, J Michael Underwood
Vaccine-preventable diseases (VPDs) cause substantial morbidity and mortality in the United States Affiliated Pacific Islands (USAPI).* CDC collaborates with USAPI immunization programs to monitor vaccination coverage. In 2016, † USAPI immunization programs and CDC piloted a method for estimating up-to-date status among children aged 2 years using medical record abstraction to ascertain regional vaccination coverage. This was the first concurrent assessment of childhood vaccination coverage across five USAPI jurisdictions (American Samoa; Chuuk State, Federated States of Micronesia [FSM]; Commonwealth of the Northern Mariana Islands [CNMI]; Republic of the Marshall Islands [RMI]; and Republic of Palau)...
May 25, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29794231/stk25-regulates-oxidative-capacity-and-metabolic-efficiency-in-adipose-tissue
#5
Silva Sütt, Emelie Cansby, Alexandra Paul, Manoj Amrutkar, Esther Nunez Duran, Nagaraj M Kulkarni, Marcus Ståhlman, Jan Borén, Jurga Laurencikiene, Brian W Howell, Sven Enerbäck, Margit Mahlapuu
Whole-body energy homoeostasis at over-nutrition critically depends on how well adipose tissue remodels in response to excess calories. We recently identified serine/threonine protein kinase (STK)25 as a critical regulator of ectopic lipid storage in non-adipose tissue and systemic insulin resistance in the context of nutritional stress. Here, we investigated the role of STK25 in regulation of adipose tissue dysfunction in mice challenged with a high-fat diet. We found that overexpression of STK25 in high-fat-fed mice resulted in impaired mitochondrial function and aggravated hypertrophy, inflammatory infiltration, and fibrosis in adipose depots...
May 24, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29793827/nontypeable-haemophilus-influenzae-nthi
#6
Lauren O Bakaletz, Laura A Novotny
In this infographic the diseases caused by nontypeable Haemophilus influenzae (NTHi), including otitis media, are discussed. Encapsulated type b Haemophilus influenzae (Hib) was responsible for most of the invasive disease (meningitis) prior to the use of Hib vaccines. As Hib vaccines have no effect on infections due to nontypeable H. influenzae (NTHi), in areas where Hib vaccines are used, nontypeable strains are now the most common cause of invasive disease. Moreover, NTHi contributes to the ∼21000 otitis media (OM)-associated deaths per year...
May 21, 2018: Trends in Microbiology
https://www.readbyqxmd.com/read/29787323/the-role-of-vaccines-in-fighting-antimicrobial-resistance-amr
#7
Kathrin U Jansen, Annaliesa S Anderson
The problem of antimicrobial resistance (AMR) and the associated morbidity and mortality due to antibiotic resistant bacterial pathogens is not new. However, AMR has been increasing at an alarming rate with appearances of diseases caused by bacteria exhibiting resistance to not just one but multiple classes of antibiotics. The World Health Organization (WHO) supported by governments, health ministries and health agencies has formulated global action plans to combat the rise in AMR, supporting a number of proven initiatives such as antimicrobial stewardship, investments in development of new classes of antibiotics, and educational programs designed to eliminate inappropriate antibiotic use...
May 22, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29784470/immunogenicity-and-safety-of-menacwy-tt-a-meningococcal-conjugate-vaccine-co-administered-with-routine-childhood-vaccine-in-healthy-infants-a-phase-iii-randomized-study
#8
Ghassan Dbaibo, Juan Carlos Tinoco Favila, Magali Traskine, Archana Jastorff, Marie Van der Wielen
BACKGROUND: Invasive meningococcal disease has a high burden in young children, particularly during infancy. We investigated the immunogenicity and safety of a quadrivalent meningococcal conjugated vaccine (MenACWY-TT) co-administered with routine vaccines in healthy infants. METHODS: In this phase IIIb study (NCT01340898) conducted in 2 centers in Lebanon and Mexico, 750 infants were randomized (2:1:1) to receive MenACWY-TT according to 3 schedules: 3+1 (at ages 2, 4, 6 and 15-18 months; group ACWY3+1); 1+1 (at 6 and 15-18 months; group ACWY1+1) or single-dose at 15-18 months (group ACWY1)...
May 18, 2018: Vaccine
https://www.readbyqxmd.com/read/29769493/immune-response-against-hepatitis-b-virus-after-pentavalent-vaccination-in-children
#9
R Karim, M S Rahman, M S Uddin
This study was done to know the real status of immune response to Hepatitis B vaccine among the pentavalent vaccinated children as per EPI schedule of Bangladesh. It was prospective observational study done in the EPI corner of Paediatric OPD of Dhaka National Medical College & Hospital (DNMCH), Dhaka from July 2015 to July 2016. Sixty (60) children ranging from 9 months to 2 years of age, who received pentavalent vaccination (Hepatitis B + DPT + Hib) according to EPI schedule, were included. The testing for anti-HBs titres were conducted in the Department of Virology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29769176/using-feeding-to-reduce-pain-during-vaccination-of-formula-fed-infants-a-randomised-controlled-trial
#10
Netty G P Bos-Veneman, Marrit Otter, Sijmen A Reijneveld
OBJECTIVES: To assess the effectiveness and potential side effects of formula feeding to reduce pain during vaccination among infants. STUDY DESIGN: In the setting of well-baby clinics we recruited a community-based sample of full-term born infants who were already formula fed by the choice of the parents (n=48, aged 4-10 weeks) and received their first DTaP-IPV-HepB-Hib and pneumococcal vaccinations and randomised them into two groups. To evaluate pain experienced during vaccination we compared infants who drank formula feeding before, during and after vaccination with infants who did not...
May 16, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29761850/unexpected-regulation-pattern-of-the-ikk%C3%AE-nf-%C3%AE%C2%BAb-murf1-pathway-with-remarkable-muscle-plasticity-in-the-daurian-ground-squirrel-spermophilus-dauricus
#11
Yanhong Wei, Lingchen Gong, Weiwei Fu, Shenhui Xu, Zhe Wang, Jie Zhang, Er Ning, Hui Chang, Huiping Wang, Yunfang Gao
As a typical hibernator, the Daurian ground squirrel (Spermophilus dauricus) spends considerable time in a state of reduced activity with prolonged fasting. Despite this, they experience little muscle atrophy and have thus become an interesting anti-disuse muscle atrophy model. The IKKβ/NF-κB signaling pathway is significant to muscle atrophy due to the protein degradation resulting from the upregulation of the E3 ubiquitin ligase MuRF1. The current study showed that the IKKβ/NF-κB signaling pathway and MuRF1 maintained relatively steady mRNA and protein expression levels, with little muscle atrophy observed in the soleus (slow-twitch, SOL) or extensor digitorum longus (fast-twitch, EDL) during hibernation (HIB); however, mRNA expression significantly increased in the SOL and EDL muscle during interbout arousal (IBA), as did the MuRF1 mRNA level in the SOL and MuRF1 protein level in the EDL...
May 15, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29752131/effectiveness-of-the-dtpa-hbv-ipv-hib-vaccine-against-invasive-haemophilus-influenzae-type-b-disease-in-the-netherlands-2003-16-a-case-control-study
#12
Susana Monge, Susan Jm Hahné, Hester E de Melker, Elisabeth Am Sanders, Arie van der Ende, Mirjam J Knol
BACKGROUND: In 2016, an increase in invasive Haemophilus influenzae serotype b (Hib) disease was reported in the Netherlands in children younger than 5 years, which coincided with the introduction of the hexavalent diphtheria, tetanus, and acellular pertussis-hepatitis B virus-inactivated polio virus/Hib vaccine (DTPa-HBV-IPV/Hib) from 2011 onwards. We aimed to estimate the effectiveness of the hexavalent vaccine to assess whether this increase could be explained by decreasing effectiveness...
May 8, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29752130/hib-combination-vaccines-efficient-and-effective
#13
Cheryl Cohen, Anne von Gottberg
No abstract text is available yet for this article.
May 8, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29720429/clinical-and-bacteriologic-analysis-of-nontypeable-haemophilus-influenzae-strains-isolated-from-children-with-invasive-diseases-japan-2008-2015
#14
Sachiko Naito, Noriko Takeuchi, Misako Ohkusu, Azusa Takahashi-Nakaguchi, Hiroki Takahashi, Naoko Imuta, Junichiro Nishi, Keigo Shibayama, Mayumi Matsuoka, Yuko Sasaki, Naruhiko Ishiwada
Haemophilus influenzae type b (Hib) conjugate vaccines have led to a dramatic reduction in Hib disease in young children worldwide. Nontypeable H. influenzae (NTHi) is now the major cause of invasive H. influenzae infection. We investigated the clinical characteristics of invasive NTHi diseases among children in Japan to clarify the pathogenicity of isolated NTHi strains. The mortality rate was 10.7%, mainly among children with underlying comorbidities. Biotypes II and III were the most common and most (64...
May 2, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29720075/surveillance-of-adverse-events-following-immunisation-in-australia-2015
#15
Aditi Dey, Han Wang, Helen Quinn, Jane Cook, Kristine Macartney
This report summarises Australian passive surveillance data for adverse events following immunisation (AEFI) for 2015 reported to the Therapeutic Goods Administration and compares them to long-term trends. There were 2,924 AEFI records for vaccines administered in 2015; an annual AEFI reporting rate of 12.3 per 100,000 population. There was a decline of 7% in the overall AEFI reporting rate in 2015 compared with 2014. This decline in reported adverse events in 2015 compared to the previous year was mainly attributable to fewer reports following the HPV vaccine and replacement of monovalent vaccines (Hib, MenCCV and varicella) with combination vaccines such as Hib-MenC, and MMRV...
September 1, 2017: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/29717696/extension-of-french-vaccination-mandates-from-the-recommendation-of-the-steering-committee-of-the-citizen-consultation-on-vaccination-to-the-law
#16
Daniel Lévy-Bruhl, Jean-Claude Desenclos, Sylvie Quelet, François Bourdillon
On 4 December 2017, French parliamentarians passed a law extending the vaccination mandates for children up to 2 years of age from three vaccinations (against diphtheria, tetanus and poliomyelitis) to 11 by adding vaccinations against pertussis, Haemophilus influenza b (Hib), hepatitis B, pneumococcal diseases, meningococcal C diseases, measles, mumps and rubella. This vote follows a recommendation made by the Steering Committee of the Citizen Consultation on Vaccination that took place in 2016. The law applies to all children born after 1 January 2018...
April 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29685594/safety-tolerability-and-immunogenicity-of-intramuscular-administration-of-prp-crm-197-hib-vaccine-to-healthy-japanese-children-an-open-label-trial
#17
Takehiro Togashi, Nodoka Mitsuya, Shuji Sumino, Yohei Takanami
BACKGROUND: Japan licensed the conjugate Haemophilus influenzae type b vaccine, Vaxem™ Hib, based on clinical studies using subcutaneous injection. The present study was performed to ensure this vaccine is suitable for intramuscular injection in Japanese children. METHODS: Thirty-one healthy 2-6-month-old infants received three doses of Vaxem™ Hib by intramuscular injection at 4-week intervals and a booster dose 1 year later, concomitant with routine infant (DTaP-IPV and pneumococcal) and toddler (measles-rubella) vaccines...
May 17, 2018: Vaccine
https://www.readbyqxmd.com/read/29675174/a-modular-synthetic-route-to-size-defined-immunogenic-haemophilus-influenzae-b-antigens-is-key-to-the-identification-of-an-octasaccharide-lead-vaccine-candidate
#18
J Y Baek, A Geissner, D C K Rathwell, D Meierhofer, C L Pereira, P H Seeberger
The first glycoconjugate vaccine using isolated glycans was licensed to protect children from Haemophilus influenzae serotype b (Hib) infections. Subsequently, the first semisynthetic glycoconjugate vaccine using a mixture of antigens derived by polymerization targeted the same pathogen. Still, a detailed understanding concerning the correlation between oligosaccharide chain length and the immune response towards the polyribosyl-ribitol-phosphate (PRP) capsular polysaccharide that surrounds Hib remains elusive...
February 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29668816/compliance-with-the-vaccination-schedule-in-children-hospitalized-with-pneumonia-and-associated-factors
#19
Amanda Tabosa Pereira da Silva, Eduardo Jorge da Fonseca Lima, Maria de Fátima Costa Caminha, Andresa Tabosa Pereira da Silva, Edil de Albuquerque Rodrigues Filho, Carmina Silva Dos Santos
OBJECTIVE: To verify the adequacy and factors associated with compliance with the immunization schedule (BCG, DTP-Hib, MMR, PCV-10) in children hospitalized with pneumonia at a pediatric referral hospital in Northeast Brazil. METHODS: This is a cross-sectional, descriptive study with an analytical component, with a sample of 452 children hospitalized with pneumonia at the Instituto de Medicina Integral Prof. Fernando Figueira, between 2010 and 2013. The inclusion criterion was children aged from one month to less than five years of age with proof in the immunization record...
2018: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29668078/adherence-and-immune-response-to-revaccination-following-hematopoietic-stem-cell-transplantation-at-a-pediatric-onco-hematology-reference-center
#20
Fernanda Gouveia-Alves, Roseane Gouveia, Valéria C Ginani, Adriana Seber, Danielle A Kuramoto, Gabriel F A Murad, Fernanda G Spina, Antonio S Petrilli, Victor G Zecchin, Celso Granato, Fabianne Carlesse, Maria Isabel de Moraes-Pinto
BACKGROUND: Revaccination after hematopoietic stem cell transplantation (HSCT) is necessary to compensate for the loss of immunological memory. The aims of this study were to evaluate the adherence to revaccination schedule and the humoral immune response to different vaccine antigens in HSCT pediatric and young adult patients. METHODS: Patients submitted to HSCT for over 3 years were recruited. After written informed consent, a questionnaire was filled in, the vaccination card was analyzed, a blood sample was collected and tested by ELISA for diphtheria, Haemophilus influenzae type b (Hib), hepatitis A, hepatitis B, tetanus, measles, rubella, and varicella antibodies...
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
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