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https://www.readbyqxmd.com/read/28737468/economic-evaluations-of-haemophilus-influenzae-type-b-hib-vaccine-a-systematic-review
#1
Bunchai Chongmelaxme, Maythika Hammanee, Wariya Phooaphirak, Surachai Kotirum, Raymond Hutubessy, Nathorn Chaiyakunapruk
AIMS: World Health Organization (WHO) recommends the use of Haemophilus influenzae type b (Hib) conjugate vaccines but only China and Thailand have not used Hib vaccination in their national immunization programs. This systematic review aimed to update published economic evaluations of Hib vaccinations and to determine factors that potentially affected their cost-effectiveness. METHODS: Searching was performed from the inception until December 2015 using 13 databases: CAB direct; CEA registry; EconLit; EMBASE; E-library; NHSEED; PAHO; POPLINE; PubMed; Redalyc project; RePEc; SciELO and WHOLIS...
July 24, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28729019/safety-reactogenicity-and-immunogenicity-of-two-investigational-pneumococcal-protein-based-vaccines-results-from-a-randomized-phase-ii-study-in-infants
#2
Roman Prymula, Leszek Szenborn, Sven-Arne Silfverdal, Jacek Wysocki, Piotr Albrecht, Magali Traskine, Asparuh Gardev, Yue Song, Dorota Borys
INTRODUCTION: Vaccination with formulations containing pneumococcal protein antigens such as pneumolysin toxoid (dPly) and histidine-triad protein D (PhtD) may extend serotype-related protection of pneumococcal conjugate vaccines (PCVs) against Streptococcus pneumoniae. METHODS: This phase II, multi-center, observer-blind trial conducted in Europe (NCT01204658) assessed 2 investigational vaccines containing 10 serotype-specific polysaccharide conjugates of PHiD-CV and either 10 or 30µg of dPly and PhtD each...
July 17, 2017: Vaccine
https://www.readbyqxmd.com/read/28702311/the-evidence-for-non-typeable-haemophilus-influenzae-as-a-causative-agent-of-childhood-pneumonia
#3
EDITORIAL
Mary P E Slack
Haemophilus influenzae type b (Hib) was a major cause of bacterial pneumonia in children prior to the introduction of Hib-conjugate vaccines. The widespread use of Hib-conjugate vaccines has resulted in a significant decline in the number of cases of invasive Hib disease, including bacteraemic pneumonia, in areas where the vaccine has been implemented. In many countries, non-typeable H. influenzae (NTHI) is now the most common cause of invasive haemophilus infection in all ages. NTHI are a recognized cause of bacteraemic and non-bacteraemic pneumonia in children and in adults...
2017: Pneumonia
https://www.readbyqxmd.com/read/28702307/childhood-pneumonia-and-meningitis-in-the-eastern-highlands-province-papua-new-guinea-in-the-era-of-conjugate-vaccines-study-methods-and-challenges
#4
Christopher C Blyth, Rebecca Ford, Joycelyn Sapura, Tonny Kumani, Geraldine Masiria, John Kave, Lapule Yuasi, Andrew Greenhill, Ilomo Hwaihwanje, Amanda Lang, Deborah Lehmann, William Pomat
BACKGROUND: Pneumonia and meningitis are common causes of severe childhood illness in Papua New Guinea (PNG). The etiology of both clinical conditions in PNG has not been recently assessed. Changes in lifestyle, provision and access to healthcare, antimicrobial utilization and resistance, and the national childhood vaccination schedule necessitate reassessment. METHODS: A prospective case-control study was undertaken, enrolling children <5 years of age to determine the contemporary etiology of clinically defined moderate or severe pneumonia or suspected meningitis...
2017: Pneumonia
https://www.readbyqxmd.com/read/28700282/a-randomized-open-label-clinical-trial-to-evaluate-immunogenicity-and-safety-of-an-indigenously-developed-dtwp-hib-tetravalent-combination-vaccine-easyfour%C3%A2-tt-with-quadrovax%C3%A2-in-indian-infants
#5
Lalitendu Mohanty, Sunil Sharma, Beauty Behera, Sachin Panwar, Charu Paliwal, Anit Singh, Anu Gupta, Deepak Chandra Chilkoti
An open-label, randomized, multi-center trial was conducted to compare the immunogenicity and safety of an indigenously developed tetravalent DTwP-Hib vaccine, Easyfour®-TT with a commercially available vaccine, Quadrovax®. A total of 244 infants in good health, aged 6-10 weeks, were randomized in a 1:1 allocation to receive three doses of the test or comparator vaccine. Immunogenicity of the vaccines was determined by measuring the baseline and post-vaccination antibody response against the vaccine antigens; safety was evaluated in terms of local and systemic reactions (solicited and unsolicited) reported during the trial...
July 12, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28696824/age-appropriate-versus-up-to-date-coverage-of-routine-childhood-vaccinations-among-young-children-in-israel
#6
Chen Stein-Zamir, Avi Israeli
BACKGROUND AND AIMS: Routine childhood vaccinations schedules recommend that children receive the vaccine doses at specific ages. Vaccination coverage data are conventionally reported by the up-to-date method. We aimed to assess vaccination timeliness by the age-appropriate method and compare with the up-to-date vaccination coverage. METHODS: Assessment of age-appropriate and up-to-date vaccination coverage among children born in Israel in 2009 and followed to age 48 months (national representative sample, n = 3892)...
July 11, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28676382/new-perspectives-for-hexavalent-vaccines
#7
Pablo Obando-Pacheco, Irene Rivero-Calle, José Gómez-Rial, Carmen Rodríguez-Tenreiro Sánchez, Federico Martinón-Torres
With the increase in the number of routine vaccinations the development of pentavalent and hexavalent combination vaccines fitting the routine vaccination schedules became a necessity. In this respect, Europe has taken the lead in comparison with other world regions, and routine vaccination with pentavalent and hexavalent combinations including DTPa, Hib, HepB and IPV has been on European vaccination programs for >15years. Since the marketing authorization of Hexavac® and Infanrix Hexa® in 2000, immunization schedules in most European countries have included hexavalent vaccines...
July 1, 2017: Vaccine
https://www.readbyqxmd.com/read/28666758/the-changing-epidemiology-of-invasive-haemophilus-influenzae-disease-emergence-and-global-presence-of-serotype-a-strains-that-may-require-a-new-vaccine-for-control
#8
Raymond S W Tsang, Marina Ulanova
BACKGROUND: More than two decades after the implementation of the Hib conjugate vaccine in North America, Haemophilus influenzae serotype a (Hia) has emerged as a significant cause of invasive disease in Indigenous communities. However, little is known about the global presence of this pathogen. METHODS: We interrogated the H. influenzae Multi-Locus Sequence Typing (MLST) website (https://pubmlst.org/hinfluenzae/) by selecting for serotype a records. We also updated our previous literature review on this subject matter...
June 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28628438/haemophilus-influenzae-type-a-meningitis-in-immunocompetent-child-oman-2015
#9
Kiran P Sawardekar
Meningitis caused by Haemophilus influenzae type b (Hib) was eliminated in Oman after the introduction of Hib vaccine in 2001. However, a case of H. influenzae type a meningitis was diagnosed in a child from Oman in 2015, which highlights the need to monitor the incidence of invasive non-Hib H. influenzae disease.
July 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28624983/how-to-increase-vaccination-acceptance-among-apostolic-communities-quantitative-results-from-an-assessment-in-three-provinces-in-zimbabwe
#10
Regina Gerede, Zorodzai Machekanyanga, Serigne Ndiaye, Kenneth Chindedza, Colline Chigodo, Messeret E Shibeshi, James Goodson, Fussum Daniel, Reinhard Kaiser
A worldwide increasing trend toward vaccine hesitancy has been reported. Measles outbreaks in southern Africa in 2009-2010 were linked to objections originating from Apostolic gatherings. Founded in Zimbabwe in the 1950s, the Apostolic church has built up a large number of followers with an estimated 3.5 million in Zimbabwe in 2014. To inform planning of interventions for the 2015 measles-rubella vaccination campaign, we assessed vaccination status and knowledge, attitudes and practices among purposive samples of Apostolic caregivers in three districts each in Harare City, Manicaland and Matabeleland South in Zimbabwe...
June 17, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28617678/single-variant-bottleneck-in-the-early-dynamics-of-h-influenzae-bacteremia-in-neonatal-rats-questions-the-theory-of-independent-action
#11
Xinxian Shao, Bruce Levin, Ilya Nemenman
There is an abundance of information about the genetic basis, physiological and molecular mechanisms of bacterial pathogenesis. In contrast, relatively little is known about population dynamic processes, by which bacteria colonize hosts and invade tissues and cells and thereby cause disease. In an article published in 1978, Moxon and Murphy presented evidence that, when inoculated intranasally with a mixture streptomycin sensitive and resistant (Sm (S) and Sm (R) ) and otherwise isogenic strains of Haemophilus influenzae type b (Hib), neonatal rats develop a bacteremic infection that often is dominated by only one strain, Sm (S) or Sm (R) ...
June 15, 2017: Physical Biology
https://www.readbyqxmd.com/read/28606216/comparable-reductions-in-hyperpnoea-induced-bronchoconstriction-and-markers-of-airway-inflammation-after-supplementation-with-6%C3%A2-2-and-3%C3%A2-1-g-d-of-long-chain-n-3-pufa-in-adults-with-asthma
#12
Neil C Williams, Kirsty A Hunter, Dominick E Shaw, Kim G Jackson, Graham R Sharpe, Michael A Johnson
Although high dose n-3 PUFA supplementation reduces exercise- and hyperpnoea-induced bronchoconstriction (EIB/HIB), there are concurrent issues with cost, compliance and gastrointestinal discomfort. It is thus pertinent to establish the efficacy of lower n-3 PUFA doses. Eight male adults with asthma and HIB and eight controls without asthma were randomly supplemented with two n-3 PUFA doses (6·2 g/d (3·7 g EPA and 2·5 g DHA) and 3·1 g/d (1·8 g EPA and 1·3 g DHA)) and a placebo, each for 21 d followed by 14 d washout...
May 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28583305/immunogenicity-and-safety-of-a-new-hexavalent-vaccine-dtap5-ipv-hb-hib-administered-in-a-mixed-primary-series-schedule-with-a-pentavalent-vaccine-dtap5-ipv-hib
#13
Federico Martinón-Torres, Florence Boisnard, Stéphane Thomas, Christine Sadorge, Ray Borrow
DTaP5-IPV-HB-Hib vaccine is a fully-liquid, combination hexavalent vaccine. This phase III, open-label, multicentre study conducted in Spain, evaluated the immune response to all DTaP5-IPV-HB-Hib antigens when the vaccine was used in a mixed hexa/penta/hexa primary series. Infants (who had received one dose of hepatitis B vaccine at birth) received a mixed schedule including DTaP5-IPV-HB-Hib (PRP-OMP conjugate) at 2 and 6months of age, DTaP5-IPV-Hib at 4months, meningococcal serogroup C conjugate (MCC) vaccine at 2 and 4months, and routine rotavirus and pneumococcal vaccination...
June 2, 2017: Vaccine
https://www.readbyqxmd.com/read/28536030/lot-to-lot-consistency-safety-and-immunogenicity-of-3-lots-of-haemophilus-influenzae-type-b-conjugate-vaccine-results-from-a-phase-iii-randomized-multicenter-study-in-infants
#14
Nicola P Klein, Remon Abu-Elyazeed, Matthew Cornish, Michael L Leonardi, Leonard B Weiner, Peter E Silas, Stanley E Grogg, Meera Varman, Robert W Frenck, Brigitte Cheuvart, Yaela Baine, Jacqueline M Miller, Maarten Leyssen, Narcisa Mesaros, Sumita Roy-Ghanta
BACKGROUND: Vaccination against Haemophilus influenzae type b (Hib) is included in routine pediatric immunization schedule in the United States. Previous vaccine shortages have created the need for additional options for Hib vaccination. METHODS: This phase III, randomized, multi-centered study (NCT01000974) evaluated the safety and immunogenicity of a monovalent tetanus toxoid-conjugate Hib vaccine (Hib-TT) compared to a monovalent (Hib-TT control) and a combination Hib-TT vaccine...
May 20, 2017: Vaccine
https://www.readbyqxmd.com/read/28536027/live-attenuated-tetravalent-g1-g4-bovine-human-reassortant-rotavirus-vaccine-brv-tv-randomized-controlled-phase-iii-study-in-indian-infants
#15
Tarun Saluja, Sonali Palkar, Puneet Misra, Madhu Gupta, Potula Venugopal, Ashwani Kumar Sood, Ravi Mandyam Dhati, Avinash Shetty, Sangappa Malappa Dhaded, Sharad Agarkhedkar, Amlan Choudhury, Ramesh Kumar, Sundaram Balasubramanian, Sudhir Babji, Lopa Adhikary, Martin Dupuy, Sangeet Mohan Chadha, Forum Desai, Darshna Kukian, Badri Narayan Patnaik, Mandeep Singh Dhingra
BACKGROUND: Rotavirus remains the leading cause of diarrhoea among children <5years. We assessed immunogenic non-inferiority of a tetravalent bovine-human reassortant rotavirus vaccine (BRV-TV) over the licensed human-bovine pentavalent rotavirus vaccine RV5. METHODS: Phase III single-blind study (parents blinded) in healthy infants randomized (1:1) to receive three doses of BRV-TV or RV5 at 6-8, 10-12, and 14-16weeks of age. All concomitantly received a licensed diphtheria, tetanus, pertussis, hepatitis B, Haemophilus influenzae type b conjugate vaccine (DTwP-HepB-Hib) and oral polio vaccine (OPV)...
May 20, 2017: Vaccine
https://www.readbyqxmd.com/read/28526365/calibration-and-validation-of-the-youth-activity-profile-the-flashe-study
#16
Pedro F Saint-Maurice, Youngwon Kim, Paul Hibbing, April Y Oh, Frank M Perna, Gregory J Welk
INTRODUCTION: This study describes the calibration and validity of the Youth Activity Profile (YAP) for use in the National Cancer Institute's Family Life, Activity, Sun, Health, and Eating (FLASHE) study. The calibrated YAP was designed to estimate minutes of moderate to vigorous physical activity (MVPA) and sedentary behavior (SB). METHODS: The YAP was calibrated/validated in adolescents (aged 12-17 years) using cross-sectional data from the FLASHE study. Participants wore a GT3X+ ActiGraph on the dominant wrist for 7 days and then completed the YAP...
June 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28526364/surveillance-of-youth-physical-activity-and-sedentary-behavior-with-wrist-accelerometry
#17
Youngwon Kim, Paul Hibbing, Pedro F Saint-Maurice, Laura D Ellingson, Erin Hennessy, Dana L Wolff-Hughes, Frank M Perna, Gregory J Welk
INTRODUCTION: Accurate tracking of physical activity (PA) and sedentary behavior (SB) is important to advance public health, but little is known about how to interpret wrist-worn accelerometer data. This study compares youth estimates of SB and moderate to vigorous PA (MVPA) obtained using raw and count-based processing methods. METHODS: Data were collected between April and October 2014 for the National Cancer Institute's Family Life, Activity, Sun, Health, and Eating Study: a cross-sectional Internet-based study of youth/family cancer prevention behaviors...
June 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28526359/understanding-and-interpreting-error-in-physical-activity-data-insights-from-the-flashe-study
#18
EDITORIAL
Gregory J Welk, Pedro F Saint-Maurice, Youngwon Kim, Laura D Ellingson, Paul Hibbing, Dana L Wolff-Hughes, Frank M Perna
No abstract text is available yet for this article.
June 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28504487/haemophilus-influenzae-type-b-meningitis-is-there-a-re-emergence-24-years-of-experience-in-a-children-s-hospital
#19
Angela Gentile, Ana C Martínez, María Del V Juarez, María F Lución, Candela Burgo, María P Della Latta, Solana Rapapor, Viviana Romanin, Marisa Turco
INTRODUCTION: Haemophilus influenzae type B (Hib) used to be the main cause of bacterial meningitis in children younger than 5 years old. Following the introduction of the Hib vaccine in the immunization schedule (1998), its incidence reduced significantly but it has increased over the last years. The objectives of this study included describing the characteristics and analyzing the epidemic curve of Haemophilus influenzae type B (Hib) meningitis by comparing the pre- and postimmunization periods...
June 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28501920/a-dramatic-blood-plasticity-in-hibernating-and-14-day-hindlimb-unloading-daurian-ground-squirrels-spermophilus-dauricus
#20
Huan-Xin Hu, Fang-Ying Du, Wei-Wei Fu, Shan-Feng Jiang, Jin Cao, Shen-Hui Xu, Hui-Ping Wang, Hui Chang, Nandu Goswami, Yun-Fang Gao
We compared the effects of hibernation inactivity and 14-day hindlimb unloading in non-hibernating period on biochemical, rheological, and hematological parameters of blood in Daurian ground squirrels (Spermophilus dauricus). Twenty-four squirrels were randomly divided into four groups: control (CON), hibernation (HIB), post-hibernation (POST), and 14-day hindlimb unloading (HU). The results showed that serum enzymes (L-lactate dehydrogenase, alanine aminotransferase, and aspartate aminotransferase) activities decreased in HIB, POST, and HU squirrels compared with CON...
May 13, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
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