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https://www.readbyqxmd.com/read/29675174/a-modular-synthetic-route-to-size-defined-immunogenic-haemophilus-influenzae-b-antigens-is-key-to-the-identification-of-an-octasaccharide-lead-vaccine-candidate
#1
J Y Baek, A Geissner, D C K Rathwell, D Meierhofer, C L Pereira, P H Seeberger
The first glycoconjugate vaccine using isolated glycans was licensed to protect children from Haemophilus influenzae serotype b (Hib) infections. Subsequently, the first semisynthetic glycoconjugate vaccine using a mixture of antigens derived by polymerization targeted the same pathogen. Still, a detailed understanding concerning the correlation between oligosaccharide chain length and the immune response towards the polyribosyl-ribitol-phosphate (PRP) capsular polysaccharide that surrounds Hib remains elusive...
February 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29668816/compliance-with-the-vaccination-schedule-in-children-hospitalized-with-pneumonia-and-associated-factors
#2
Amanda Tabosa Pereira da Silva, Eduardo Jorge da Fonseca Lima, Maria de Fátima Costa Caminha, Andresa Tabosa Pereira da Silva, Edil de Albuquerque Rodrigues Filho, Carmina Silva Dos Santos
OBJECTIVE: To verify the adequacy and factors associated with compliance with the immunization schedule (BCG, DTP-Hib, MMR, PCV-10) in children hospitalized with pneumonia at a pediatric referral hospital in Northeast Brazil. METHODS: This is a cross-sectional, descriptive study with an analytical component, with a sample of 452 children hospitalized with pneumonia at the Instituto de Medicina Integral Prof. Fernando Figueira, between 2010 and 2013. The inclusion criterion was children aged from one month to less than five years of age with proof in the immunization record...
2018: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29668078/adherence-and-immune-response-to-revaccination-following-hematopoietic-stem-cell-transplantation-at-a-pediatric-onco-hematology-reference-center
#3
Fernanda Gouveia-Alves, Roseane Gouveia, Valéria C Ginani, Adriana Seber, Danielle A Kuramoto, Gabriel F A Murad, Fernanda G Spina, Antonio S Petrilli, Victor G Zecchin, Celso Granato, Fabianne Carlesse, M Isabel de Moraes-Pinto
BACKGROUND: Revaccination after hematopoietic stem cell transplantation (HSCT) is necessary to compensate for the loss of immunological memory. The aims of this study were to evaluate the adherence to revaccination schedule and the humoral immune response to different vaccine antigens in HSCT pediatric and young adult patients. METHODS: Patients submitted to HSCT for over 3 years were recruited. After written informed consent, a questionnaire was filled in, the vaccination card was analyzed, a blood sample was collected and tested by ELISA for diphtheria, Haemophilus influenzae type b (Hib), hepatitis A, hepatitis B, tetanus, measles, rubella and varicella antibodies...
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29663096/plasmids-carrying-dha-1-%C3%AE-lactamases
#4
REVIEW
Claire Hennequin, Viviane Ravet, Frédéric Robin
The aim of this review is to provide an update on the plasmids mediating DHA-1 cephalosporinase in Klebsiella pneumoniae. These plasmids have been mainly found in this bacterium but not only. The first was isolated from Salmonella sp. in France in the early 1990s. They are currently reported worldwide. BlaDHA-1 beta-lactamase gene is usually co-expressed with many other antibiotic resistance genes such as extended-spectrum β-lactamases (blaCTX-M -, bla SHV -types), oxacillinases (blaOXA-1, blaOXA-30 ), penicillinases (bla TEM -type), carbapenemases (bla OXA48 , blaKPC-2 ), aminoglycosides (aacA, aadA, armA), fluoroquinolones (qnrB4, aac6'-1b-cr), and sulfonamide (sul1) resistance genes...
April 17, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29655624/post-immunization-leucocytosis-and-its-implications-for-the-management-of-febrile-infants
#5
Sarah Prentice, Zephyrian Kamushaaga, Stephen B Nash, Alison M Elliott, Hazel M Dockrell, Stephen Cose
AIMS: Clinical guidelines for management of infants with fever but no evident focus of infection recommend that those aged 1-3 months with a white cell count >15 × 109 /l have a full septic screen and be admitted for parenteral antibiotics. However, there is limited information about leucocyte changes following routine immunization, a common cause of fever. We investigated white cell counts shortly after routine immunization in Ugandan infants under 3 months of age. METHODS: White cell counts were measured in 212 healthy infants following routine immunizations (DTwP-HepB-Hib, oral polio and pneumococcal conjugate 7 vaccines) received prior to 3 months of age...
April 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29620722/immunogenicity-and-reactogenicity-of-dtpa-hbv-ipv-hib-and-phid-cv-when-co-administered-with-menacwy-tt-in-infants-results-of-an-open-randomized-trial
#6
Jose Manuel Merino Arribas, Alfonso Carmona Martínez, Michael Horn, Xavier Maria Perez Porcuna, Maria Del Carmen Otero Reigada, Josep Marès Bermúdez, Fernando Centeno Malfaz, Mariano Miranda, Maria Mendez, Miguel Angel Garcia Cabezas, Wittermann Christoph, Gerhard Bleckmann, Thomas Fischbach, Devayani Kolhe, Marie Van der Wielen, Yaela Baine
BACKGROUND: This study evaluated the immunogenicity and reactogenicity of a combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus virus-Haemophilus influenzae type b vaccine (DTPa-HBV-IPV/Hib) and a 10-valent pneumococcal conjugate vaccine (PHiD-CV) co-administered with a quadrivalent meningococcal conjugate vaccine (MenACWY-TT) in infants/toddlers. METHODS: In this open, controlled, phase III study (NCT01144663), 2095 healthy infants were randomised (1:1:1:1) into 4 groups to receive MenACWY-TT at 2, 3, 4 and 12 months of age, or MenACWY-TT, MenC-CRM197 or MenC-TT at 2, 4 and 12 months of age...
March 31, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29606518/factors-associated-with-routine-immunization-coverage-of-children-under-one-year-old-in-lao-people-s-democratic-republic
#7
Bounfeng Phoummalaysith, Eiko Yamamoto, Anonh Xeuatvongsa, Viengsakhone Louangpradith, Bounxou Keohavong, Yu Mon Saw, Nobuyuki Hamajima
BACKGROUND: Routine vaccination is administered free of charge to all children under one year old in Lao People's Democratic Republic (Lao PDR) and the national goal is to achieve at least 95% coverage with all vaccines included in the national immunization program by 2025. In this study, factors related to the immunization system and characteristics of provinces and districts in Lao PDR were examined to evaluate the association with routine immunization coverage. METHODS: Coverage rates for Bacillus Calmette-Guerin (BCG), Diphtheria-Tetanus-Pertussis-Hepatitis B (DTP-HepB), DTP-HepB-Hib (Haemophilus influenzae type B), polio (OPV), and measles (MCV1) vaccines from 2002 to 2014 collected through regular reporting system, were used to identify the immunization coverage trends in Lao PDR...
March 29, 2018: Vaccine
https://www.readbyqxmd.com/read/29595417/genotypic-characterization-of-haemophilus-influenzae-isolates-from-paediatric-patients-in-japan
#8
Yoko Adachi, Mariko Ando, Miyuki Morozumi, Kimiko Ubukata, Satoshi Iwata
PURPOSE: β-lactamase-negative ampicillin-resistant (BLNAR) Haemophilus influenzae is frequently isolated from respiratory samples and is particularly problematic in Japan. The aim of this study was to characterize circulating isolates of H. influenzae genotypically by BLNAR-PCR and multilocus sequence typing (MLST), and to determine any associations between them. METHODS: H. influenzae isolates (n=191) were collected from paediatric patients (1 month to 12 years old) between 2000 and 2011 for three types of infections: pneumonia (n=61), acute otitis media (AOM) (n=68) and meningitis (n=62)...
March 29, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29580640/a-randomized-open-label-trial-to-evaluate-and-compare-the-immunogenicity-and-safety-of-a-novel-liquid-hexavalent-dtwp-hib-hep-b-ipv-easysix%C3%A2-to-licensed-combination-vaccines-in-healthy-infants
#9
Lalitendu Mohanty, Sunil Sharma, Beauty Behera, Sachin Panwar, Charu Paliwal, Anu Gupta, Deepak Chandra Chilkoti, Anit Singh
Immunogenicity and safety of a newly developed liquid DTwP-Hib/HepB-IPV hexavalent vaccine (EasySix™) was evaluated and compared with administration of commercially licensed Pentavac SD® (DTwP-HepB/Hib) and Imovax Polio® vaccine in an open-label, randomized multi-centric trial. 284 participants, aged 6-10weeks, randomized in a 1:1 allocation, received three doses of test or comparator vaccines, administered 4weeks apart. Immunogenicity of the vaccines was determined by measuring the baseline and post-vaccination antibody responses and comparing the proportions of subjects achieving seroprotection against the vaccine antigens; safety was evaluated in terms of solicited (local and systemic) and unsolicited incidences in the follow up phase...
April 19, 2018: Vaccine
https://www.readbyqxmd.com/read/29573974/the-risk-of-neurodevelopmental-disorders-following-thimerosal-containing-hib-vaccine-in-comparison-to-thimerosal-free-hib-vaccine-administered-from-1995-to-1999-in-the-united-states
#10
David A Geier, Janet K Kern, Kristin G Homme, Mark R Geier
Investigators postulated that early-life exposure to organic mercury (Hg) significantly increases the risk of childhood neurodevelopmental disorders (NDs). The Vaccine Adverse Event Reporting System database was utilized to conduct a hypothesis testing case-control study by evaluating 3486 total adverse event reports reported following Haemophilus influenza type b (Hib) vaccination. Exposed subjects received a Thimerosal-containing formulation (HIBTITER™, Wyeth-Lederle), while unexposed subjects received a Thimerosal-free formulation (PEDVAXHIB™, Merck)...
March 14, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29546927/-hypotonic-hyporesponsive-episode-after-immunization-with-whole-cell-pertussis-combination-vaccine-clinical-case-report
#11
Juliana Velasco, David A Montero, Miguel Guzmán
INTRODUCTION: Hypotonic-Hyporesponsive Episode (HHE) is an adverse event after vaccination, mainly associated with whole-cell pertussis vaccines. It is characterized by a sudden onset of muscle flaccidity, reduced response to stimuli and pallor or cyanosis. Although the HHE is infrequent, it is considered a severe adverse event. OBJECTIVE: To report a case of HHE following the administration of the whole-cell pertussis combination vaccine (DTwP-HB-Hib), which is included in National Im munization Program (PNI) of Chile, and to contributing to the knowledge of this adverse event in the country...
December 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29540644/the-incidence-of-pediatric-invasive-bacterial-diseases-in-nippon-medical-school-chiba-hokusoh-hospital-before-and-after-the-introduction-of-conjugate-vaccines
#12
Toumi Sano, Tamaho Suzuki, Ayako Nishigori, Chiharu Miyatake, Shinya Koizumi, Kiyohiko Kaizu, Atsushi Fujita, Mitsuhiro Kamisago, Bin Chang, Naruhiko Ishiwada, Takeshi Asano
The introduction of the Haemophilus influenzae type b (Hib) vaccine and the 7-valent pneumococcal conjugate vaccine (PCV7) has led to dramatic reductions in cases of invasive H. influenzae disease and invasive pneumococcal disease (IPD). After the introduction of the PCV7 and the 13-valent pneumococcal conjugate vaccine (PCV13), the number of children with IPD markedly decreased in our hospital. However, since 2015, three children with IPD have been admitted to our hospital. We analyzed the serotype, multilocus sequence type, and antimicrobial susceptibility of Streptococcus pneumoniae strains isolated in these newly diagnosed cases...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29523052/influence-of-music-style-and-rate-on-repetitive-finger-tapping
#13
Elizabeth L Stegemöller, Joshua R Tatz, Alison Warnecke, Paul Hibbing, Brandon Bates, Andrew Zaman
Auditory cues, including music, are commonly used in the treatment of persons with Parkinson's disease. Yet, how music style and movement rate modulate movement performance in persons with Parkinson's disease have been neglected and remain limited in healthy young populations. The purpose of this study was to determine how music style and movement rate influence movement performance in healthy young adults. Healthy participants were asked to perform repetitive finger movements at two pacing rates (70 and 140 beats per minute) for the following conditions: (a) a tone only, (b) activating music, and (c) relaxing music...
March 9, 2018: Motor Control
https://www.readbyqxmd.com/read/29514773/effect-of-mobile-phone-text-message-reminders-on-routine-immunization-uptake-in-pakistan-randomized-controlled-trial
#14
Abdul Momin Kazi, Murtaza Ali, Khurram Zubair, Hussain Kalimuddin, Abdul Nafey Kazi, Saleem Perwaiz Iqbal, Jean-Paul Collet, Syed Asad Ali
BACKGROUND: Improved routine immunization (RI) coverage is recommended as the priority public health strategy to decrease vaccine-preventable diseases and eradicate polio in Pakistan and worldwide. OBJECTIVE: The objective of this study was to ascertain whether customized, automated, one-way text messaging (short message service, SMS) reminders delivered to caregivers via mobile phones when a child is due for an RI visit can improve vaccination uptake and timelines in Pakistan...
March 7, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29511602/infectious-disease-risk-and-vaccination-in-northern-syria-after-5-years-of-civil-war-the-msf-experience
#15
Alan de Lima Pereira, Rosamund Southgate, Hikmet Ahmed, Penelope O'Connor, Vanessa Cramond, Annick Lenglet
Introduction: In 2015, following an influx of population into Kobanê in northern Syria, Médecins Sans Frontières (MSF) in collaboration with the Kobanê Health Administration (KHA) initiated primary healthcare activities. A vaccination coverage survey and vaccine-preventable disease (VPD) risk analysis were undertaken to clarify the VPD risk and vaccination needs. This was followed by a measles Supplementary Immunization Activity (SIA). We describe the methods and results used for this prioritisation activity around vaccination in Kobanê in 2015...
February 2, 2018: PLoS Currents
https://www.readbyqxmd.com/read/29509834/current-epidemiology-and-trends-in-invasive-haemophilus-influenzae-disease-united-states-2009-2015
#16
Heidi M Soeters, Amy Blain, Tracy Pondo, Brooke Doman, Monica M Farley, Lee H Harrison, Ruth Lynfield, Lisa Miller, Susan Petit, Arthur Reingold, William Schaffner, Ann Thomas, Shelley M Zansky, Xin Wang, Elizabeth C Briere
Background: Following Haemophilus influenzae serotype b (Hib) conjugate vaccine introduction in the 1980s, Hib disease in young children dramatically decreased and epidemiology of invasive H. influenzae changed. Methods: Active surveillance for invasive H. influenzae disease was conducted through Active Bacterial Core surveillance sites. Incidence rates were directly standardized to the age and race distribution of the US population. Results: During 2009-2015, the estimated mean annual incidence of invasive H...
March 2, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29507247/structure-based-discovery-of-glycomimetic-fmlh-ligands-as-inhibitors-of-bacterial-adhesion-during-urinary-tract-infection
#17
Vasilios Kalas, Michael E Hibbing, Amarendar Reddy Maddirala, Ryan Chugani, Jerome S Pinkner, Laurel K Mydock-McGrane, Matt S Conover, James W Janetka, Scott J Hultgren
Treatment of bacterial infections is becoming a serious clinical challenge due to the global dissemination of multidrug antibiotic resistance, necessitating the search for alternative treatments to disarm the virulence mechanisms underlying these infections. Uropathogenic Escherichia coli (UPEC) employs multiple chaperone-usher pathway pili tipped with adhesins with diverse receptor specificities to colonize various host tissues and habitats. For example, UPEC F9 pili specifically bind galactose or N -acetylgalactosamine epitopes on the kidney and inflamed bladder...
March 5, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29471470/a-registry-for-patients-with-asplenia-hyposplenism-reduces-the-risk-of-infections-with-encapsulated-organisms
#18
Alicia Arnott, Penelope Jones, Lucinda J Franklin, Denis Spelman, Karin Leder, Allen C Cheng
Background: Overwhelming post-splenectomy infection (OPSI) is a serious complication of asplenia. Clinical guidelines recommend a number of measures to reduce the risk of OPSI, but awareness and adherence to preventative measures is generally poor. We aimed to determine whether a registry for asplenic/hyposplenic patients was associated with a reduction in the incidence of infection with encapsulated bacteria. Methods: We performed a retrospective cohort study of asplenic/hyposplenic patients in the state of Victoria, Australia who registered with Spleen Australia from 2003 - 2014...
February 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29459064/comparison-of-serum-bactericidal-and-antibody-titers-induced-by-two-haemophilus-influenzae-type-b-conjugate-vaccines-a-phase-iii-randomized-double-blind-study
#19
Yukihiro Akeda, Yuka Koizumi, Yohei Takanami, Shuji Sumino, Yumi Hattori, Kayoko Sugizaki, Nodoka Mitsuya, Kazunori Oishi
Haemophilus influenzae type b (Hib) conjugate vaccines have drastically reduced disease incidence worldwide. Protection against Hib infection has relied on the serum bactericidal activity (SBA) of antibodies to the Hib capsular polysaccharide (polyribosylribitol phosphate). However, licensure usually relies on measuring induction of antibodies to PRP as a surrogate for SBA. In a phase III clinical trial we compared a PRP-conjugate vaccine using the nontoxic diphtheria toxin mutant, CRM197 , as carrier protein with the licensed tetanus toxoid conjugate when administered subcutaneously as a three dose primary series in Japanese infants...
February 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29459062/cost-effectiveness-of-a-potential-vaccine-candidate-for-haemophilus-influenzae-serotype-a
#20
Affan Shoukat, Robert Van Exan, Seyed M Moghadas
The preceding decade has witnessed the emergence of severe community-acquired acute infections caused by Haemophilus influenzae serotype a (Hia), with alarming incidence rates in North America, particularly among indigenous populations. The remarkable success of Hib conjugate vaccine over the past 20 years signify the development of an Hia vaccine candidate as a prevention measure to reduce the incidence of invasive Hia disease. However, quantifications of the long-term epidemiologic and economic impacts of vaccination are needed to inform decision on investment in Hia vaccine development and immunization programs...
February 16, 2018: Vaccine
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