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https://www.readbyqxmd.com/read/29777925/epidemiology-of-respiratory-pathogen-carriage-in-the-homeless-population-within-2-shelters-in-marseille-france-2015-2017-cross-sectional-one-day-surveys
#1
Tran Duc Anh Ly, Sophie Edouard, Sekene Badiaga, Herve Tissot-Dupont, Van Thuan Hoang, Vincent Pommier de Santi, Philippe Brouqui, Didier Raoult, Philippe Gautret
OBJECTIVES: To assess risk factors for respiratory tract infection symptoms and signs in sheltered homeless people in Marseille during the winter season, including pathogen carriage. METHODS: Data on 479 male participants within 2 shelters who completed questionnaires and a total of 950 nasal and pharyngeal samples were collected during the winters of 2015-2017. Respiratory pathogen carriage including 7 viruses and 4 bacteria was assessed by quantitative polymerase chain reaction...
May 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29776416/rapid-urease-test-rut-for-evaluation-of-urease-activity-in-oral-bacteria-in-vitro-and-in-supragingival-dental-plaque-ex-vivo
#2
Gunnar Dahlén, Haidar Hassan, Susanne Blomqvist, Anette Carlén
BACKGROUND: Urease is an enzyme produced by plaque bacteria hydrolysing urea from saliva and gingival exudate into ammonia in order to regulate the pH in the dental biofilm. The aim of this study was to assess the urease activity among oral bacterial species by using the rapid urease test (RUT) in a micro-plate format and to examine whether this test could be used for measuring the urease activity in site-specific supragingival dental plaque samples ex vivo. METHODS: The RUT test is based on 2% urea in peptone broth solution and with phenol red at pH 6...
May 18, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29774014/oral-microbiota-community-dynamics-associated-with-oral-squamous-cell-carcinoma-staging
#3
Chia-Yu Yang, Yuan-Ming Yeh, Hai-Ying Yu, Chia-Yin Chin, Chia-Wei Hsu, Hsuan Liu, Po-Jung Huang, Song-Nian Hu, Chun-Ta Liao, Kai-Ping Chang, Yu-Liang Chang
Oral squamous cell carcinoma (OSCC) is a highly aggressive cancer and the fourth leading malignancy among males in Taiwan. Some pathogenic bacteria are associated with periodontitis and oral cancer. However, the comprehensive profile of the oral microbiome during the cancer's progression from the early stage to the late stage is still unclear. We profiled the oral microbiota and identified bacteria biomarkers associated with OSCC. The microbiota of an oral rinse from 51 healthy individuals and 197 OSCC patients at different stages were investigated using 16S rRNA V3V4 amplicon sequencing, followed by bioinformatics and statistical analyses...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29770580/q969r-polymorphism-in-nlrp3-is-associated-with-immune-responses-to-vaccination-against-bacterial-infections-in-pigs
#4
Hiroki Shinkai, Kei Terada, Daisuke Toki, Masanori Tohno, Hirohide Uenishi
Nucleotide-binding domain, leucine-rich-containing family, pyrin-domain containing-3 (NLRP3) is an important pattern recognition receptor involved in various inflammatory responses and adjuvant effects upon vaccination. We previously identified the Q969R (A2906G) gain-of-function polymorphism in porcine NLRP3, which increased production of interleukin-1β in in vitro gene transfection experiments. Here, we explored the associations between the A2906G polymorphism and antibody responses after vaccination against bacteria in Large White pigs maintained under specific pathogen-free conditions...
May 17, 2018: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/29762363/immunogenicity-and-safety-of-primary-and-booster-vaccinations-of-a-fully-liquid-dtap-ipv-hb-prp-t-hexavalent-vaccine-in-healthy-infants-and-toddlers-in-germany-and-the-czech-republic
#5
Roman Prymula, Dorothee Kieninger, Emmanuel Feroldi, Emilia Jordanov, Siham B'Chir, Xavier DaCosta
BACKGROUND: To support a fully liquid, diphtheria (D)-tetanus (T)-acellular pertussis (aP)-inactivated poliovirus (IPV)-hepatitis B (HB)-Haemophilus influenzae b (PRP-T) vaccine in Europe using a 2, 3, 4 month primary series and a booster at 11 to 15 months of age. METHODS: Phase III, randomized, observer-blind studies in Germany and the Czech Republic. Participants who had not received HB vaccine were randomized to a 2, 3, 4 month primary series of DTaP-IPV-HB-PRP-T (Group 1; N=266) or a reconstituted DTaPHB-IPV//PRP-T comparator (Group 2; N=263) and a booster of the same vaccine...
May 14, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29760213/changes-in-iga-protease-expression-are-conferred-by-changes-in-genomes-during-persistent-infection-by-nontypeable-haemophilus-influenzae-in-chronic-obstructive-pulmonary-disease
#6
Mary C Gallo, Charmaine Kirkham, Samantha Eng, Remon S Bebawee, Yong Kong, Melinda M Pettigrew, Hervé Tettelin, Timothy F Murphy
Nontypeable Haemophilus influenzae (NTHi) is an exclusively human pathobiont that plays a critical role in the course and pathogenesis of chronic obstructive pulmonary disease (COPD). NTHi causes acute exacerbations of COPD and also causes persistent infection of the lower airways. NTHi expresses four IgA protease variants (A1, A2, B1, and B2) that play different roles in virulence. Expression of IgA proteases varies among NTHi strains, but little is known about the frequency and mechanisms by which NTHi modulates IgA protease expression during infection in COPD...
May 14, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29756174/phenotypic-detection-of-clinical-isolates-of-haemophilus-influenzae-with-altered-penicillin-binding-protein-3
#7
A Aguirre-Quiñonero, I C Pérez Del Molino, C García de la Fuente, M C Sanjuán, J Agüero, L Martínez-Martínez
The aims of this study were to determine the correlation of mutations in the ftsI gene (coding for PBP3) of Haemophilus influenzae with aminopenicillin resistance and to evaluate the 2017 European Committee for Antibiotic Susceptibility Testing (EUCAST) guidelines for clinical categorization of ampicillin, amoxicillin, and amoxicillin-clavulanate for strains with mutated PBP3 conferring resistance (rPBP3). A panel of 91 H. influenzae isolates was genetically characterized by sequencing of the fstI gene. For all the studied isolates, a screening with benzylpenicillin 1U (BP1) was carried out and minimum inhibitory concentrations (MICs) of ampicillin, amoxicillin, and amoxicillin-clavulanate were tested and interpreted according to EUCAST recommendations...
May 13, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29754466/temporal-trends-in-paediatric-bacterial-meningitis-in-a-tropical-australian-region-1992-2014
#8
Stephanie White, Hala Katf, Rob Baird, Joshua Francis
AIM: The epidemiology of community-acquired bacterial meningitis has changed following the introduction of routine immunisation against common causative organisms. Indigenous children living in the Northern Territory, Australia, have high rates of bacterial infections. This study describes changes in the epidemiology of childhood bacterial meningitis and the distribution of the burden of disease in the Top End. METHODS: A retrospective review of cases derived from hospital medical records and laboratory data was performed...
May 13, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29752131/effectiveness-of-the-dtpa-hbv-ipv-hib-vaccine-against-invasive-haemophilus-influenzae-type-b-disease-in-the-netherlands-2003-16-a-case-control-study
#9
Susana Monge, Susan Jm Hahné, Hester E de Melker, Elisabeth Am Sanders, Arie van der Ende, Mirjam J Knol
BACKGROUND: In 2016, an increase in invasive Haemophilus influenzae serotype b (Hib) disease was reported in the Netherlands in children younger than 5 years, which coincided with the introduction of the hexavalent diphtheria, tetanus, and acellular pertussis-hepatitis B virus-inactivated polio virus/Hib vaccine (DTPa-HBV-IPV/Hib) from 2011 onwards. We aimed to estimate the effectiveness of the hexavalent vaccine to assess whether this increase could be explained by decreasing effectiveness...
May 8, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29749871/first-reported-case-of-chancroid-in-the-czech-republic
#10
Filip Rob, David Jilich, Šárka Lásiková, Veronika Křížková, Jana Hercogová
We describe the first case of chancroid seen in the Czech Republic, diagnosed in a 40-year-old heterosexual HIV-positive man. Despite genital localization of the ulcer, the transmission of Haemophilus ducreyi infection in our patient remains unclear, as he denied having sexual intercourse and he did not travel outside the Czech Republic for several months before the ulcer appeared. The correct diagnosis has been revealed by a multiplex nucleic acid amplification test. Physicians in countries in the eastern and central Europe region should be aware that chancroid can occur in their patients...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29746872/the-contribution-of-the-dna-microarray-technology-to-gene-expression-profiling-in-leishmania-spp-a-retrospective
#11
REVIEW
Ana Alonso, Vicente Larraga, Pedro J Alcolea
The first genome project of any living organism excluding viruses, the gammaproteobacteria Haemophilus influenzae, was completed in 1995. Until the last decade, genome sequencing was very tedious because genome survey sequences (GSS) and/or expressed sequence tags (ESTs) belonging to plasmid, cosmid and artificial chromosome genome libraries had to be sequenced and assembled in silico. Nowadays, no genome is completely assembled actually, because gaps and unassembled contigs are always remaining. However, most represent the whole genome of the organism of origin from a practical point of view...
May 7, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29746527/characterization-of-a-nontypeable-haemophilus-influenzae-thermonuclease
#12
Christine Cho, Aroon T Chande, Lokesh Gakhar, Jason Hunt, Margaret R Ketterer, Michael A Apicella
Nontypeable Haemophilus influenzae (NTHi) has been shown to form biofilms, comprised of extracellular DNA (eDNA), in the middle ear and bronchus during clinical infections. Studies in our laboratory have shown that NTHi possesses a homolog of Staphylococcus aureus thermonuclease (staphylococcal thermonuclease), NTHi nuclease (NTHi Nuc, HI_1296). This enzyme had similar size, heat stability, and divalent cation requirements to those of the staphylococcal homolog as determined by light scattering and circular dichroism spectroscopy...
2018: PloS One
https://www.readbyqxmd.com/read/29746496/pharyngeal-colonization-and-drug-resistance-profiles-of-morraxella-catarrrhalis-streptococcus-pneumoniae-staphylococcus-aureus-and-haemophilus-influenzae-among-hiv-infected-children-attending-art-clinic-of-felegehiwot-referral-hospital-ethiopia
#13
Wondemagegn Mulu, Endalew Yizengaw, Megbaru Alemu, Daniel Mekonnen, Derese Hailu, Kassaw Ketemaw, Bayeh Abera, Mulugeta Kibret
BACKGROUND: Asymptomatic pharyngeal colonization by potential bacteria is the primary reservoir for bacterial species within a population and is considered a prerequisite for development of major childhood diseases such as sinusitis, otitis media, pneumonia, bacteremia, and meningitis. However, there is dearth of data on the colonization and drug resistance pattern of the main bacterial pathogens in the pharynx of HIV infected children in Ethiopia. Therefore, this study determined the pharyngeal colonization and drug resistance profile of bacterial pathogens in HIV infected children attending ART clinic of Felegehiwot Referral Hospital (FHRH), Amhara Region, Ethiopia...
2018: PloS One
https://www.readbyqxmd.com/read/29743502/the-amino-acid-selected-for-generating-mutant-tbpb-antigens-defective-in-binding-transferrin-can-compromise-the-in-vivo-protective-capacity
#14
João Antônio Guizzo, Somshukla Chaudhuri, Simone Ramos Prigol, Rong-Hua Yu, Cláudia Cerutti Dazzi, Natalia Balbinott, Gabriela Paraboni Frandoloso, Luiz Carlos Kreutz, Rafael Frandoloso, Anthony Bernard Schryvers
Haemophilus parasuis is the causative agent of the Glässer's disease (GD), one of the most important bacterial diseases that affect young pigs worldwide. GD prevention based on vaccination is a major concern due to the limited cross-protection conferred by the inactivated whole cell vaccines used currently. In this study, vaccines based on two mutant recombinant proteins derived from transferrin binding protein B of H. parasuis (Y167A-TbpB and W176A-TbpB) were formulated and evaluated in terms of protection against lethal challenge using a serovar 7 (SV7) H...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29742648/comparison-of-bacterial-culture-results-obtained-from-nasopharyngeal-and-mid-turbinate-swabs-in-children-with-upper-respiratory-tract-infection-symptoms
#15
Judith M Martin, Anita Simonian, Gysella Muniz, Michael Green, Nader Shaikh
Paired NP and MT swabs were obtained from 96 children (mean age 2.45 years) with upper respiratory tract symptoms. Of these, 38.5% were colonized with Streptococcus pneumoniae only, 16.7% with Haemophilus influenzae only, 9.4% with both bacteria. Bacterial cultures from paired NP and MT swabs demonstrated agreement for S. pneumoniae (Kappa=0.75), H. influenzae (K=0.59) and for both pathogens (K=0.62).
May 4, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29727705/relation-between-lower-respiratory-tract-microbiota-and-type-of-immune-response-against-tuberculosis
#16
Maede Nakhaee, Abdolrahim Rezaee, Reza Basiri, Saman Soleimanpour, Kiarash Ghazvini
In this study, the interaction between the microbiota of the lower respiratory tract and the type of immune response against Mycobacterium tuberculosis were studied. Bronchoalveolar lavage (BAL) samples of 10 tuberculosis (TB) patients and 5 cases suspected of lung cancer as control were obtained. Clinical symptoms were recorded for the TB patients. Serial dilutions of samples were prepared and cultured on a selective medium in order to count Streptococcus spp., Neisseria spp., Haemophilus spp. and Veillonella in the lung...
May 1, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29725272/the-role-of-regulatory-t-cell-in-nontypeable-haemophilus-influenzae-induced-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#17
Xuewa Guan, Yanjiao Lu, Guoqiang Wang, Peter Gibson, Fang Chen, Keyong Fang, Ziyan Wang, Zhiqiang Pang, Yingqiao Guo, Junying Lu, Yuze Yuan, Nan Ran, Fang Wang
Chronic obstructive pulmonary disease (COPD) is associated with irreversible persistent airflow limitation and enhanced inflammation. The episodes of acute exacerbation (AECOPD) largely depend on the colonized pathogens such as nontypeable Haemophilus influenzae (NTHi), one of the most commonly isolated bacteria. Regulatory T cells (Tregs) are critical in controlling inflammatory immune responses and maintaining tolerance; however, their role in AECOPD is poorly understood. In this study, we hypothesized a regulatory role of Tregs, as NTHi participated in the progress of COPD...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29720703/modulation-of-haemophilus-influenzae-interaction-with-hydrophobic-molecules-by-the-vacj-mlaa-lipoprotein-impacts-strongly-on-its-interplay-with-the-airways
#18
Ariadna Fernández-Calvet, Irene Rodríguez-Arce, Goizeder Almagro, Javier Moleres, Begoña Euba, Lucía Caballero, Sara Martí, José Ramos-Vivas, Toby Leigh Bartholomew, Xabier Morales, Carlos Ortíz-de-Solórzano, José Enrique Yuste, José Antonio Bengoechea, Raquel Conde-Álvarez, Junkal Garmendia
Airway infection by nontypeable Haemophilus influenzae (NTHi) associates to chronic obstructive pulmonary disease (COPD) exacerbation and asthma neutrophilic airway inflammation. Lipids are key inflammatory mediators in these disease conditions and consequently, NTHi may encounter free fatty acids during airway persistence. However, molecular information on the interplay NTHi-free fatty acids is limited, and we lack evidence on the importance of such interaction to infection. Maintenance of the outer membrane lipid asymmetry may play an essential role in NTHi barrier function and interaction with hydrophobic molecules...
May 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29720429/clinical-and-bacteriologic-analysis-of-nontypeable-haemophilus-influenzae-strains-isolated-from-children-with-invasive-diseases-japan-2008-2015
#19
Sachiko Naito, Noriko Takeuchi, Misako Ohkusu, Azusa Takahashi-Nakaguchi, Hiroki Takahashi, Naoko Imuta, Junichiro Nishi, Keigo Shibayama, Mayumi Matsuoka, Yuko Sasaki, Naruhiko Ishiwada
Haemophilus influenzae type b (Hib) conjugate vaccines have led to a dramatic reduction in Hib disease in young children worldwide. Nontypeable H. influenzae (NTHi) is now the major cause of invasive H. influenzae infection. We investigated the clinical characteristics of invasive NTHi diseases among children in Japan to clarify the pathogenicity of isolated NTHi strains. The mortality rate was 10.7%, mainly among children with underlying comorbidities. Biotypes II and III were the most common and most (64...
May 2, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29717696/extension-of-french-vaccination-mandates-from-the-recommendation-of-the-steering-committee-of-the-citizen-consultation-on-vaccination-to-the-law
#20
Daniel Lévy-Bruhl, Jean-Claude Desenclos, Sylvie Quelet, François Bourdillon
On 4 December 2017, French parliamentarians passed a law extending the vaccination mandates for children up to 2 years of age from three vaccinations (against diphtheria, tetanus and poliomyelitis) to 11 by adding vaccinations against pertussis, Haemophilus influenza b (Hib), hepatitis B, pneumococcal diseases, meningococcal C diseases, measles, mumps and rubella. This vote follows a recommendation made by the Steering Committee of the Citizen Consultation on Vaccination that took place in 2016. The law applies to all children born after 1 January 2018...
April 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
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