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https://www.readbyqxmd.com/read/29128757/lethal-murine-infection-model-for-human-respiratory-disease-associated-pteropine-orthoreovirus
#1
Yuta Kanai, Takahiro Kawagishi, Minoru Okamoto, Yusuke Sakai, Yoshiharu Matsuura, Takeshi Kobayashi
Pteropine orthoreovirus (PRV) is an emerging bat-borne human pathogen causing severe respiratory illness. To date, however, the evaluation of PRV virulence has largely depended on the limited numbers of clinical cases owing to the lack of animal models. To develop an in vivo model of PRV infection, an inbred C3H mouse strain was infected intranasally with pathogenic PRV strain Miyazaki-Bali/2007. C3H mice suffered severe lung infection with significant body weight reduction and died within 7 days after intranasal infection...
November 9, 2017: Virology
https://www.readbyqxmd.com/read/29050950/modeling-and-comparative-study-of-the-spread-of-zoonotic-visceral-leishmaniasis-from-northern-to-central-tunisia
#2
Belhassen Kaabi, Elyes Zhioua
During the last twenty years, zoonotic visceral leishmaniasis (ZVL) spread from the north characterized by humid, sub-humid, and semi-arid bio-climates to the arid areas located in Central Tunisia. In order to understand the eco-epidemiological factors involved in the distribution of ZVL, both a sero-epidemiological and an entomological investigation were performed in two governorates situated in two different bio-geographical areas: Bizerte in the north and Kairouan in the center. A mathematical model for transmission of ZVL was built, describing the disease dynamic in these areas...
October 16, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28982579/sero-epidemiology-and-hemato-biochemical-study-of-bovine-leptospirosis-in-flood-affected-zone-of-pakistan
#3
Muhammad Ijaz, Syed Nazar Abbas, Shahid Hussain Farooqi, Amjad Islam Aqib, Ghulam Ali Anwar, Abdul Rehman, Muhammad Muddassir Ali, Khalid Mehmood, Amjad Khan
The bovine leptospirosis is an economically important zoonotic disease of flood affected areas worldwide, but scarce information is available about its epidemiology in Pakistan. This is a first study on sero-epidemiology of bovine leptospirosis in Pakistan. The objectives of this study were to investigate the sero-prevalence and associated risk factors of bovine leptospirosis in flood affected zone of Punjab, Pakistan. A total of 385 serum samples were randomly collected from four tehsils of district Muzaffargarh, Pakistan...
October 2, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28945755/estimating-the-burden-of-scrub-typhus-a-systematic-review
#4
REVIEW
Ana Bonell, Yoel Lubell, Paul N Newton, John A Crump, Daniel H Paris
BACKGROUND: Scrub typhus is a vector-borne zoonotic disease that can be life-threatening. There are no licensed vaccines, or vector control efforts in place. Despite increasing awareness in endemic regions, the public health burden and global distribution of scrub typhus remains poorly known. METHODS: We systematically reviewed all literature from public health records, fever studies and reports available on the Ovid MEDLINE, Embase Classic + Embase and EconLit databases, to estimate the burden of scrub typhus since the year 2000...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28940523/epidemiology-of-helicobacter-pylori-infection-in-asymptomatic-schoolchildren-in-bhutan
#5
Sonam Wangda, James M Richter, Pema Kuenzang, Kinley Wangchuk, Tashi Choden, Karma Tenzin, Hoda M Malaty
AIM: Bhutan is a small mountainous country between Tibet and India with relatively homogenous population. According to the World Health Organization, gastric cancer is the most frequent cause of cancer death in Bhutan. This study examined the prevalence of Helicobacter pylori among children in Bhutan with emphasis on water source and living conditions. METHODS: A cross-sectional sero-epidemiologic study was conducted among schoolchildren who attended public schools in Thimphu, Bhutan...
September 22, 2017: Helicobacter
https://www.readbyqxmd.com/read/28923024/sero-epidemiology-study-of-leptospirosis-in-febrile-patients-from-terai-region-of-nepal
#6
Lalmani Regmi, Kishor Pandey, Meena Malla, Santosh Khanal, Basu Dev Pandey
BACKGROUND: Leptospirosis is a re-emerging zoonotic disease caused by pathogenic strains of bacteria belonging to genus Leptospira whose symptoms can range from mild clinical manifestations to a severe life threatening illness. This disease may be under-recognized in resource poor settings like Nepal where many clinical laboratories lack appropriate equipment, technology and personnel for proper diagnosis. METHODS: We used IgM ELISA to estimate the sero-prevalence of leptospirosis in a group of febrile patients in a western region of Nepal...
September 18, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28886050/establishing-contemporary-trends-in-hepatitis-b-sero-epidemiology-in-an-indigenous-population
#7
Jane Davies, Shu Qin Li, Steven Y Tong, Rob W Baird, Miles Beaman, Geoff Higgins, Benjamin C Cowie, John R Condon, Joshua S Davis
BACKGROUND: Indigenous populations globally are disproportionately affected by chronic hepatitis B virus (HBV) infection however contemporary sero-prevalence data are often absent. In the Indigenous population of the Northern Territory (NT) of Australia the unique C4 sub-genotype of HBV universally circulates. There are no studies of the sero-prevalence, nor the impact of the vaccination program (which has a serotype mismatch compared to C4), at a population-wide level. METHODS: We examined all available HBV serology results obtained from the three main laboratories serving NT residents between 1991 and 2011...
2017: PloS One
https://www.readbyqxmd.com/read/28835490/asymptomatic-primary-infection-with-epstein-barr-virus-observations-on-young-adult-cases
#8
Rachel J Abbott, Annette Pachnio, Isabela Pedroza-Pacheco, Alison M Leese, Jusnara Begum, Heather M Long, Debbie Croom-Carter, Andrea Stacey, Paul A H Moss, Andrew D Hislop, Persephone Borrow, Alan B Rickinson, Andrew I Bell
Epstein-Barr virus (EBV) is typically acquired asymptomatically in childhood. In contrast, infection later in life often leads to infectious mononucleosis (IM), a febrile illness characterized by anti-EBV IgM antibody positivity, high loads of circulating latently infected B cells, and a marked lymphocytosis caused by hyperexpansion of EBV-specific CD8(+) T cells plus a milder expansion of CD56(dim) NKG2A(+) KIR(-) natural killer (NK) cells. How the two situations compare is unclear due to the paucity of studies on clinically silent infection...
November 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28831122/naturally-acquired-antibody-response-to-plasmodium-falciparum-describes-heterogeneity-in-transmission-on-islands-in-lake-victoria
#9
Zulkarnain Md Idris, Chim W Chan, James Kongere, Tom Hall, John Logedi, Jesse Gitaka, Chris Drakeley, Akira Kaneko
As markers of exposure anti-malaria antibody responses can help characterise heterogeneity in malaria transmission. In the present study antibody responses to Plasmodium falciparum AMA-1, MSP-119 and CSP were measured with the aim to describe transmission patterns in meso-endemic settings in Lake Victoria. Two cross-sectional surveys were conducted in Lake Victoria in January and August 2012. The study area comprised of three settings: mainland (Ungoye), large island (Mfangano) and small islands (Takawiri, Kibuogi, Ngodhe)...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28783594/antigenic-characterization-of-52-55kda-protein-isolated-from-trypanosoma-evansi-and-its-application-in-detection-of-equine-trypanosomosis
#10
S C Yadav, Ritesh Kumar, Jaideep Kumar, Meetali Singh, B C Bera, Rajender Kumar, U Tatu, Kanika Tehri
Trypanosoma evansi is a haemo-protozoan parasite responsible for the disease surra, an economically important disease of wide range of domestic and wild animals. The present diagnostic methods using soluble antigens have inherent problems like lack of standardized and reproducible antigens, as well as ethical issues. This entails further efforts for search of defined antigenic molecules with satisfying sensitivity and specificity for sero-epidemiology of trypanosomosis. In present investigation, we have identified and purified 52-55kDa immuno-dominant protein cluster in molecular mass ranges by preparatory SDS-PAGE methods from T...
August 1, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28764717/a-longitudinal-cohort-study-of-malaria-exposure-and-changing-serostatus-in-a-malaria-endemic-area-of-rural-tanzania
#11
Ryan A Simmons, Leonard Mboera, Marie Lynn Miranda, Alison Morris, Gillian Stresman, Elizabeth L Turner, Randall Kramer, Chris Drakeley, Wendy P O'Meara
BACKGROUND: Measurements of anti-malarial antibodies are increasingly used as a proxy of transmission intensity. Most serological surveys are based on the use of cross-sectional data that, when age-stratified, approximates historical patterns of transmission within a population. Comparatively few studies leverage longitudinal data to explicitly relate individual infection events with subsequent antibody responses. METHODS: The occurrence of seroconversion and seroreversion events for two Plasmodium falciparum asexual stage antigens (MSP-1 and AMA-1) was examined using three annual measurements of 691 individuals from a cohort of individuals in a malaria-endemic area of rural east-central Tanzania...
August 2, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28753243/a-sero-epidemiological-survey-of-the-effect-of-hepatitis-b-vaccine-and-hepatitis-b-and-c-virus-infections-among-elementary-school-students-in-siem-reap-province-cambodia
#12
Mayumi Fujimoto, Channarena Chuon, Shintaro Nagashima, Chikako Yamamoto, Ko Ko, Sonama Svay, Sirany Hok, Olline Lim, Masayuki Ohisa, Tomoyuki Akita, Keiko Katayama, Junko Matsuo, Kazuaki Takahashi, Junko Tanaka
AIM: This study aimed to survey the prevalence and incidence of hepatitis B (HBV) and hepatitis C virus (HCV) infection among elementary school students in Siem Reap province, Cambodia and to evaluate the effects of a national infant HBV vaccination program introduced in 2001. METHODS: The 3(rd) grade students during 2011, 2012 and 2013 Academic years were enrolled in this study and they became 5(th) or 6(th) grade students in 2014-2015 Academic year at their second time examination...
July 28, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28727726/a-cross-sectional-seroepidemiological-survey-of-typhoid-fever-in-fiji
#13
Conall H Watson, Stephen Baker, Colleen L Lau, Kitione Rawalai, Mere Taufa, Jerimaia Coriakula, Nga Tran Vu Thieu, Tan Trinh Van, Dung Tran Thi Ngoc, Niel Hens, John H Lowry, Ruklanthi de Alwis, Jorge Cano, Kylie Jenkins, E Kim Mulholland, Eric J Nilles, Mike Kama, W John Edmunds
Fiji, an upper-middle income state in the Pacific Ocean, has experienced an increase in confirmed case notifications of enteric fever caused by Salmonella enterica serovar Typhi (S. Typhi). To characterize the epidemiology of typhoid exposure, we conducted a cross-sectional sero-epidemiological survey measuring IgG against the Vi antigen of S. Typhi to estimate the effect of age, ethnicity, and other variables on seroprevalence. Epidemiologically relevant cut-off titres were established using a mixed model analysis of data from recovering culture-confirmed typhoid cases...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28693608/temporal-analysis-of-igg-antibody-responses-to-plasmodium-falciparum-antigens-in-relation-to-changing-malaria-epidemiology-in-a-west-african-setting
#14
Makhtar Niang, Oumy Niass, Nafissatou Diagne, Fatoumata Diene Sarr, Michel Matar Faye, Fode Diop, Babacar Diouf, Joseph Faye, Abdoulaye Badiane, Ronald Perraut, Cheikh Sokhna, Jean-François Trape, Adama Tall, Aissatou Toure-Balde
BACKGROUND: Coordinated scaled-up malaria control interventions have substantially contributed to the dramatic decrease of malaria-related morbidity and mortality in several endemic countries, including Senegal. However, the impacts of a given malaria control intervention on vector and parasite populations, acquired immunity, and disease burden remain very poorly documented largely due to the lack of continuous surveys. This study took advantage of the sera bank established as part of the Dielmo longitudinal project to investigate the dynamics of IgG antibody responses that accompanied the epidemiological changes resulting from malaria control interventions...
July 11, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28693081/-a-sero-epidemiological-study-of-hepatitis-e-among-general-population-in-shandong-province-of-china-in-2014
#15
B Y Yan, L Zhang, J J Lyu, Y Feng, J Y Liu, W L Wu, L Z Song, A Q Xu
Objective: To analyze the sero-epidemiological characteristics of hepatitis E virus (HEV) in Shandong province, and thereby to provide evidence for the policy-making of hepatitis E prevention and control. Methods: The inhabitants aged between 1-59 years old were randomly selected to participate in the study by two-stage stratified random sampling method from 12 counties in Shandong province in October, 2014. Firstly two townships were selected from each county by probability proportional to size sampling (PPS) method...
July 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28686589/the-sero-epidemiology-of-rift-valley-fever-in-people-in-the-lake-victoria-basin-of-western-kenya
#16
Elizabeth Anne Jessie Cook, Elysse Noel Grossi-Soyster, William Anson de Glanville, Lian Francesca Thomas, Samuel Kariuki, Barend Mark de Clare Bronsvoort, Claire Njeri Wamae, Angelle Desiree LaBeaud, Eric Maurice Fèvre
Rift Valley fever virus (RVFV) is a zoonotic arbovirus affecting livestock and people. This study was conducted in western Kenya where RVFV outbreaks have not previously been reported. The aims were to document the seroprevalence and risk factors for RVFV antibodies in a community-based sample from western Kenya and compare this with slaughterhouse workers in the same region who are considered a high-risk group for RVFV exposure. The study was conducted in western Kenya between July 2010 and November 2012. Individuals were recruited from randomly selected homesteads and a census of slaughterhouses...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28669054/trichomonas-vaginalis-infection-and-risk-of-prostate-cancer-associations-by-disease-aggressiveness-and-race-ethnicity-in-the-plco-trial
#17
Miguelle Marous, Wen-Yi Huang, Charles S Rabkin, Richard B Hayes, John F Alderete, Bernard Rosner, Robert L Grubb, Anke C Winter, Siobhan Sutcliffe
PURPOSE: Results from previous sero-epidemiologic studies of Trichomonas vaginalis infection and prostate cancer (PCa) support a positive association between this sexually transmitted infection and aggressive PCa. However, findings from previous studies are not entirely consistent, and only one has investigated the possible relation between T. vaginalis seropositivity and PCa in African-American men who are at highest risk of both infection and PCa. Therefore, we examined this possible relation in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, including separate analyses for aggressive PCa and African-American men...
August 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28646697/seroepidemiology-of-whooping-cough-in-the-czech-republic-estimates-of-incidence-of-infection-in-adults
#18
MULTICENTER STUDY
R Chlibek, J Smetana, R Sosovickova, K Fabianova, J Zavadilova, P Dite, P Gal, P Naplava, D Lzicarova
OBJECTIVES: Despite widespread vaccination programmes, pertussis remains a significant health burden in many countries. Low awareness of the disease, the high rate of asymptomatic cases in adults and difficulties with diagnosis could explain the under-reporting of pertussis. The lack of data on actual incidence constitutes an obstacle for public health authorities for the implementation of a vaccination strategy against pertussis in adults. The aim of this study was to evaluate the seroprevalence of antibodies against Bordetella pertussis infection in adults and to estimate the actual incidence of the disease compared with the reported incidence...
September 2017: Public Health
https://www.readbyqxmd.com/read/28611853/an-unsettled-debate-about-the-potential-role-of-infection-in-pathogenesis-of-atherosclerosis
#19
REVIEW
Udip Dahal, Dikshya Sharma, Kumud Dahal
Association of infection with atherosclerosis is by no means new. Several sero-epidemiological and pathologic studies as well as animal models have shown a link between infection and atherosclerosis. Exciting discoveries in recent times related to role of inter-individual genetic variation in modulating inflammatory response to infection have reignited the enthusiasm in proving a causal link between infection and atherosclerosis. The purpose of this article was to review and analyze the available evidence linking infection with atherosclerosis...
July 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28599792/a-cross-sectional-survey-measuring-sero-incidence-of-pertussis-infection-among-japanese-junior-and-senior-high-school-students-in-2013-and-2014
#20
Hideyuki Ikematsu, Naoki Kawai, Shigehiro Yajima
Pertussis in adolescents has been increasingly documented in recent years, but diagnosis from the clinical symptoms is difficult. Serological diagnosis with IgG antibody to pertussis toxin (IgG PT) is useful for detecting pertussis cases in this population. However, no serological criterion for recent infection has been fully validated and large-scale, longitudinal serological data among Japanese junior and senior high school students are lacking. Paired serum samples of 3243 junior and senior high school students, collected in 2013 and 2014, were analyzed for IgG PT and its relationship to possible risk factors...
July 5, 2017: Vaccine
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