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Ryan E Wiegand, Gretchen Cooley, Brook Goodhew, Natalie Banniettis, Stephan Kohlhoff, Sarah Gwyn, Diana L Martin
Latent class modeling can be used to combine the results of multiple tests to compare the sensitivity and specificity of those tests in the absence of a gold standard. Seroepidemiology for chlamydia infection may be useful for determining the cumulative risk of infection within a population. Initial studies using the Chlamydia trachomatis immunodominant antigen Pgp3 have shown utility for seroepidemiology of sexually transmitted chlamydia and the eye disease trachoma. We present our latent class modeling results for comparison of antibody data obtained from three different Pgp3-based platforms - multiplex bead array, ELISA, and lateral flow assay...
March 9, 2018: Scientific Reports
Cosme Alvarado-Esquivel, Maria Del Carmen Terrones-Saldivar, Jesus Hernandez-Tinoco, Maria Daniela Enriqueta Munoz-Terrones, Roberto Oswaldo Gallegos-Gonzalez, Luis Francisco Sanchez-Anguiano, Martha Elena Reyes-Robles, Elizabeth Irasema Antuna-Salcido
Background: Infection with cytomegalovirus (CMV) during pregnancy may lead to congenital disease. Very little is known about the seroepidemiology of CMV infection in pregnant women in Mexico. We sought to determine the seroprevalence and correlates of CMV infection in pregnant women in Aguascalientes City, Mexico. Methods: Through a cross-sectional study design, 289 pregnant women were examined for anti-CMV IgG and IgM antibodies in Aguascalientes City, Mexico. A standardized questionnaire was used to obtain the socio-demographic, clinical and behavioral characteristics of the pregnant women...
April 2018: Journal of Clinical Medicine Research
Akira Endo, Keisuke Ejima, Hiroshi Nishiura
PURPOSE: To explore the heterogeneous transmission dynamics for influenza and identify the optimal serum antibody titer cutoff values for estimating its cumulative incidence. METHODS: We constructed a mathematical model describing serologically dependent disease transmission. The diagnostic performances of two serum antibody titer tests (single serum test and paired sera test) were evaluated, and cumulative disease incidence estimators were formulated. The model simulated the 2009 Japanese influenza A/H1N1 epidemic and investigated the optimal cutoff values and cumulative incidence estimates for this epidemic...
February 21, 2018: Annals of Epidemiology
A P Pipia, A Varcasia, G Dessì, R Panzalis, C Gai, F Nonnis, F Veronesi, C Tamponi, A Scala
Pigs are an important reservoir of Toxoplasma gondii, and pork meat is considered one of the main sources of human infection. The present survey assesses the prevalence of T. gondii in organically reared pigs in Sardinia found on the island using various diagnostic methods. Firstly, a seroepidemiological survey was carried out on 63 farms, examining individual blood samples from 414 adult pigs. Secondly, a biomolecular investigation carried out on another 62 farms, examining the brain samples from 107 adult pigs...
March 2, 2018: Parasitology Research
Rahşan Erturk, Ömer Poyraz, Turabi Güneş
Background & objectives: Q fever caused by Coxiella burnetii is a zoonotic infection that spreads to human beings from animals. This study was aimed to demographically examine the C. burnetii seroprevalence in the people living in villages where Crimean-Congo haemorrhagic fever virus (CCHFV) is endemic, in terms of various risk factors such as tick bites, tick contact, and occupational groups. Methods: A total of 440 serum samples from those living in rural areas of Sivas and Tokat regions in Turkey were included in the study as a risk group; 387of them were serologically CCHFV positive (as confirmed in our previous research)...
October 2017: Journal of Vector Borne Diseases
Nataša Beader, Branko Kolarić, Domagoj Slačanac, Irena Tabain, Tatjana Vilibić-Čavlek
BACKGROUND: The Epstein-Barr virus (EBV) is one of the most common viruses found in humans, causing lifelong infection in up to 95% of the world population. OBJECTIVES: To analyze the seroprevalence of EBV infection in different population groups in Croatia. METHODS: During a 2 year period (2015-2016), a total of 2022 consecutive serum samples collected from Croatian residents were tested for the presence of EBV-specific viral capsid antigen (VCA) immunoglobulin M (IgM) and IgG antibodies using an enzyme-linked immunoassay...
February 2018: Israel Medical Association Journal: IMAJ
Cosme Alvarado-Esquivel, Maria Alba Guadalupe Corella-Madueno, Jesus Hernandez-Tinoco, Antonio Rascon-Careaga, Luis Francisco Sanchez-Anguiano, Karla Guadalupe Martinez-Robinson, Maria Lourdes Aldana-Madrid, Trinidad Quizan-Plata, Maria Guadalupe Canez-Carrasco, Cinthia Jhovanna Perez-Martinez
Background: Through a cross-sectional survey, we determined the seroprevalence and correlates of Toxoplasma gondii (T. gondii) infection in women of reproductive age in Hermosillo City, Mexico. Methods: We studied 445 women of reproductive age in Hermosillo City in the northwestern Mexican state of Sonora. Women were enrolled in the University of Sonora. Sera of women were examined for IgG and IgM antibodies to T. gondii by commercially available enzyme immunoassays...
March 2018: Journal of Clinical Medicine Research
Qi Zhu, Xiaoping Shao, Shaoli Chen, Dingliang Li, Xiaohong Chen, Wenjin Liu, Xianghua Wu, Zengyong Jian, Rutherford Shannon, Huizhen Zheng
OBJECTIVE: A cross sectional community prevalence survey was conducted to investigate the seroepidemiological features of Hepatitis B virus (HBV) infection among children aged 1-14 years in Guangdong Province, and to provide baseline data for the evaluation of HBV disease burden and the impacts of HBV control. METHODS: 2765 children aged 1-14 years old from 16 villages/streets of 8 cities in Guangdong province were recruited as subjects. A blood sample was obtained from each subject...
February 2, 2018: International Journal of Infectious Diseases: IJID
N Yao, Q Zeng, Q Wang
OBJECTIVES: In order to gain further insight into the seroepidemiology of Bordetella pertussis infection and immunity against diphtheria in Chongqing, China, the concentrations of antibodies to pertussis toxin (PT) and diphtheria toxin (DT) were investigated in a healthy population. STUDY DESIGN: Cross-sectional study. METHODS: In total, 1080 healthy people were recruited into this study. Sera antibodies to DT and PT were measured quantitatively using commercial enzyme-linked immunosorbent assay kits...
February 1, 2018: Public Health
Dora Romero-Salas, Cosme Alvarado-Esquivel, Gladys Domínguez-Aguilar, Anabel Cruz-Romero, Nelly Ibarra-Priego, Carolina Barrientos-Salcedo, Mariel Aguilar-Domínguez, Rodolfo Canseco-Sedano, Luz Teresa Espín-Iturbe, Luis Francisco Sánchez-Anguiano, Jesús Hernández-Tinoco, Adalberto A Pérez de León
We aimed to determine the seroprevalence of infection with Neospora caninum, Leptospira , and bovine herpesvirus type 1 and risk factors associated with these infections in water buffaloes in Veracruz State, Mexico. Through a cross-sectional study, 144 water buffaloes (Bubalus bubalis) raised in 5 ranches of Veracruz were examined for anti-N. caninum and anti-bovine herpesvirus type 1 antibodies by enzyme immunoassays, and anti-Leptospira interrogans antibodies by microscopic agglutination test. Of the 144 buffaloes studied, 35 (24...
December 18, 2017: European Journal of Microbiology & Immunology
Gytis Dudas, Luiz Max Carvalho, Andrew Rambaut, Trevor Bedford
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus from camels causing significant mortality and morbidity in humans in the Arabian Peninsula. The epidemiology of the virus remains poorly understood, and while case-based and seroepidemiological studies have been employed extensively throughout the epidemic, viral sequence data have not been utilised to their full potential. Here we use existing MERS-CoV sequence data to explore its phylodynamics in two of its known major hosts, humans and camels...
January 16, 2018: ELife
J Daniel Kelly, Mohamed Bailor Barrie, Annelies W Mesman, Sahr Karku, Komba Quiwa, Michael Drasher, Gabriel Warren Slough, Kerry Dierberg, Songor Koedoyoma, Christina P Lindan, James Holland Jones, Gabriel Chamie, Lee Worden, Bryan Greenhouse, Sheri D Weiser, Travis C Porco, George W Rutherford, Eugene T Richardson
Studies have yet to include minimally symptomatic Ebola virus (EBOV) infections and unrecognized Ebola virus disease (EVD) in Ebola-related transmission chains and epidemiologic risk estimates. We conducted a cross-sectional, sero-epidemiological survey from October 2015 to January 2016 among 221 individuals living in quarantined households from November 2014 to February 2015 during the Ebola outbreak in the village of Sukudu, Sierra Leone. Of 48 EBOV infected-persons, 25% (95%CI, 14-40%) had minimally symptomatic EBOV infections and 4% (95%CI, 1-14%) were unrecognized EVD cases...
January 9, 2018: Journal of Infectious Diseases
Rui Zhu, Tong Cheng, Zhichao Yin, Dongxiao Liu, Longfa Xu, Yongchao Li, Wei Wang, Jian Liu, Yuqiong Que, Xiangzhong Ye, Qiyi Tang, Qinjian Zhao, Shengxiang Ge, Shuizhen He, Ningshao Xia
Human enteroviruses (EVs) are the most common causative agents infecting human, causing many harmful diseases, such as hand, foot, and mouth disease (HFMD), herpangina (HA), myocarditis, encephalitis, and aseptic meningitis. EV-related diseases pose a serious worldwide threat to public health. To gain comprehensive insight into the seroepidemiology of major prevalent EVs in humans, we firstly performed a serological survey for neutralizing antibodies (nAbs) against Enterovirus A71 (EV-A71), Coxsackie virus A16 (CV-A16), Coxsackie virus A6 (CV-A6), Coxsackie virus A10 (CV-A10), Coxsackie virus B3 (CV-B3), Coxsackie virus B5 (CV-B5), Echovirus 25 (ECHO25), and Echovirus 30 (ECHO30) among the healthy population in Xiamen City in 2016, using micro-neutralization assay...
January 10, 2018: Emerging Microbes & Infections
Mohsen Moghoofei, Seyed Hamidreza Monavari, Shayan Mostafaei, Shima Hadifar, Amir Ghasemi, Farhad Babaei, Hoda Kavosi, Ahmad Tavakoli, Davod Javanmard, Maryam Esghaei, Nilofar Khodabandehlou
OBJECTIVE: This systematic review and meta-analysis was performed to determine the prevalence rate of influenza virus from different parts of Middle East region, and present an overall relative frequency (RF) for this region. METHODS: The authors performed a systematic literature review from several reliable databases such as PubMed, ISI Web of Science and Scopus during 2000-2016. Furthermore, the keywords of this research were "Influenza", "Subtype", "Seroprevalence", "Incidence", "Seroepidemiology", "H1N1", "H3N2", "H5N1", "H9N2", "Middle-East", and "Meta-analysis"...
January 8, 2018: Clinical Respiratory Journal
Arthur Löve, Thora B Björnsdottir, Sigurdur Olafsson, Einar S Björnsson
OBJECTIVE: Hepatitis E virus (HEV) infection has been reported to be more prevalent in the developed countries than previously thought. HEV infection is an important differential diagnosis in patients with drug-induced liver injury (DILI). The prevalence of hepatitis E was investigated in the general population of Iceland, among pig farmers and patients with DILI. MATERIALS AND METHODS: Serum samples were tested for hepatitis E IgG, with two commercial ELISA tests: Diagnostic Bioprobes Srl...
January 8, 2018: Scandinavian Journal of Gastroenterology
Sergio Kamminga, Els van der Meijden, Herman F Wunderink, Antoine Touzé, Hans L Zaaijer, Mariet C W Feltkamp
Introduction The family of polyomaviruses, which cause severe disease in immunocompromised hosts, has expanded substantially in recent years. To accommodate measurement of IgG seroresponses against all currently known human polyomavirus (HPyV), including the Lyon IARC polyomavirus (LIPyV), we extended our custom multiplex bead-based HPyV immunoassay and evaluated the performance of this pan-HPyV immunoassay.Methods VP1 protein of fifteen HPyVs belonging to 13 polyomavirus species were expressed as recombinant glutathione S-transferase (GST) fusion proteins and coupled to fluorescent Luminex beads...
January 5, 2018: Journal of Clinical Microbiology
Majid Mohsenizadeh, Hamid Reza Mollaei, Motahareh Ghaziizadeh
Background: Infections transmitted through blood transfusions are the most important issue associated with blood donation. We aimed to provide an assessment of the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) among blood donors in Kerman province of Iran. Methods: Between 2014-2016, 99,187 samples were examined in a retrospective study in five blood transfusion centers in Kerman province. Serologic screening for HBsAg, anti-HCV and anti-HIV1/2 was conducted for all samples and positive cases were confirmed...
December 29, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Helien Bebek-Ivanković, Svjetlana Grgić, Ivo Curić, Jadranka Nikolić
The prospective study, which was made from Jan 1st 2009. till Dec 31st 2010. in the Clinic for Infectious Diseases within Clinical Hospital Mostar has been implemented in the areas of three southwestern cantons of the Federation of Bosnia and Herzegovina. We wanted to define the seroprevalence of the researched area using seroepidemiological testing of different groups of the population, based on the distribution by sex, age, education, residence and watersupply. The aim of this research was to prove the hypothesis that the decrease of seroprevalency of Hepatitis A has been directly related to the improvement of socio-economic conditions of life that at the end brought the decrease of the total prevalence in patients in younger age groups...
December 2017: Psychiatria Danubina
Giulio Grandi, Eva Osterman Lind, Roland Schaper, Erik Ågren, Manuela Schnyder
BACKGROUND: For the first time in Sweden, Angiostrongylus vasorum was detected on the island of Sydkoster in foxes and dogs in 2003. After sporadic detection of the parasite in foxes in southern Sweden, the first positive canine faecal sample on the mainland was found in 2011. Since then a total of 2882 faecal samples have been analysed with the Baermann test at the National Veterinary Institute (SVA) during the years 2011-2015; 20 of them being positive. Contemporaneously, of over 525 fox necropsies, only three were found to be infected...
December 19, 2017: Acta Veterinaria Scandinavica
Mohammad Hassan Kayedi, Hamid Mokhayeri, Mehdi Birjandi, Ali Chegeni-Sharafi, Saber Esmaeili, Ehsan Mostafavi
Background and Objectives: Q fever is a zoonotic disease and farm animals serve as the main reservoir of the disease. The aim of this study was to evaluate the seroprevalence of Q fever in sheep, in Lorestan province in western Iran. Materials and Methods: In this cross-sectional study, 330 blood samples were collected from sheep, from each county in Lorestan province. The samples were tested by ELISA for the presence of immunoglobulin (IgG) against Coxiella burnetii...
August 2017: Iranian Journal of Microbiology
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