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John H-O Pettersson, Vegard Eldholm, Stephen J Seligman, Åke Lundkvist, Andrew K Falconar, Michael W Gaunt, Didier Musso, Antoine Nougairède, Remi Charrel, Ernest A Gould, Xavier de Lamballerie
The unexpected emergence of Zika virus (ZIKV) in the Pacific Islands and Latin America and its association with congenital Zika virus syndrome (CZVS) (which includes microcephaly) and Guillain-Barré syndrome (GBS) have stimulated wide-ranging research. High densities of susceptible Aedes spp., immunologically naive human populations, global population growth with increased urbanization, and escalation of global transportation of humans and commercial goods carrying vectors and ZIKV undoubtedly enhanced the emergence of ZIKV...
October 11, 2016: MBio
Frederick Palm, Pirkko J Pussinen, Annette Aigner, Heiko Becher, Florian Buggle, Matthias F Bauer, Caspar Grond-Ginsbach, Anton Safer, Christian Urbanek, Armin J Grau
BACKGROUND AND AIMS: Infectious diseases contribute to stroke risk, and are associated with socioeconomic status (SES). We tested the hypotheses that the aggregate burden of infections increases the risk of ischemic stroke (IS) and partly explains the association between low SES and ischemic stroke. METHODS: In a case-control study with 470 ischemic stroke patients and 809 age- and sex-matched controls, randomly selected from the population, antibodies against the periodontal microbial agents Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, against Chlamydia pneumonia, Mycoplasma pneumoniae (IgA and IgG), and CagA-positive Helicobacter pylori (IgG) were assessed...
October 5, 2016: Atherosclerosis
Laetitia Lempereur, Ludovic Martinelle, Françoise Marechal, Calixte Bayrou, Anne Catherine Dalemans, Manuela Schnyder, Bertrand Losson
BACKGROUND: Canine angiostrongylosis, a gastropod-borne helminthic infection, is increasingly being described in North America and is now reported in many European countries. In dogs, Angiostrongylus vasorum may cause a wide spectrum of clinical signs. Respiratory distress such as coughing and dyspnoea are the most frequently described manifestations. The aim of the present study was to gain additional information on the distribution, prevalence and risk factors associated with A. vasorum infection in dog from southern Belgium through the combined used of a commercially available in-clinic assay for detection of circulating antigen (Angio Detect™, IDEXX, Westbrook, USA) and coprology in two different canine populations: dogs with clinical signs compatible with angiostrongylosis and asymptomatic dogs or dogs presented for unrelated conditions (control)...
October 6, 2016: Parasites & Vectors
Matthias Claus, Renate Kimbel, Klaus Schöne, Stephan Letzel, Dirk-Matthias Rose
This study aims to assess serostatus and vaccination status of hepatitis A and B among staff at schools for the handicapped. We also wanted to investigate factors associated with serostatus, number of infections with hepatitis A/hepatitis B at work, and factors influencing being vaccinated or not. The cross-sectional study was carried out between August 2010 and August 2012 at 13 German schools for severely handicapped. Data were analyzed using blood samples, vaccination documents, and questionnaires. A total of 395 persons participated in our study (response: 59...
October 3, 2016: Journal of Medical Virology
Wei Jiang, Yan Wang, Yingchun Liu, Tao Li, Yongjun Chen, Shaohui Wang, Xiangan Han, Quan Wang
The aim of this study was to determine the seroprevalence of Leishmania infantum and Toxoplasma gondii among household dogs in Shanghai (the most important industrial and commercial city in China), and to assess the possible risk factors associated with the infection. During 2014-2015, a total of 408 sera were collected from healthy household dogs and tested for L. infantum and T. gondii infection using commercial ELISA kits. The endemic characteristics according to gender, age group and breed were revealed by statistical descriptions and inference...
September 2016: Annals of Agricultural and Environmental Medicine: AAEM
Yingying Ding, Zhihong Wang, Xi Zhang, Zheng Teng, Caixia Gao, Baohua Qian, Lili Wang, Jiaojiao Feng, Jinhong Wang, Chunyan Zhao, Cunjiu Guo, Wei Pan
Coxsackievirus A16 (CA16) is one of the major causative agents of hand, foot, and mouth disease worldwide. The non-neutralizing antibody response that targets CA16 VP1 remains poorly elucidated. In the present study, antibody responses against CA16 VP1 in Shanghai blood donors and Shanxi individuals were analyzed by ELISA and inhibitory ELISA using five CA16 VP1 antigens: VP11-297, VP141-297, VP11-60, VP145-58 and VP161-297. The correlation coefficients for most of the reactions against each of the five antigens and the inhibition of the anti-CA16 VP1 antibody response produced by the various antigens were higher in Shanghai blood donors compared to those in Shanxi individuals...
2016: PloS One
Siraj Ahmed Khan, Trishna Bora, Suchismita Chattopadhyay, Ju Jiang, Allen L Richards, Prafulla Dutta
BACKGROUND: Resurgence of scrub typhus was reported in Northeast India in 2010 after a gap of 67 years since World War II. However, the presence of other rickettsial infections remained unknown from this region. A seroepidemiological investigation was undertaken in the scrub typhus affected areas from 2013-2015 in Assam, Arunachal Pradesh and Nagaland to assess the exposure to other rickettsial diseases besides scrub typhus. METHODS: Samples were collected from people residing in scrub typhus reporting areas...
August 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
Tatjana Vilibic-Cavlek, Branko Kolaric, Natasa Beader, Izabela Vrtar, Irena Tabain, Gordana Mlinaric-Galinovic
BACKGROUND: Cytomegalovirus (CMV) is endemic worldwide, with marked differences in the seroprevalence rates between countries. The aim of this study was to analyze the seroprevalence of CMV infections in Croatia. METHODS: During a 3-year period (2013-2015) 2438 consecutive serum samples collected from Croatian residents were tested for the presence of CMV IgM and IgG antibodies using enzyme-linked immunoassay. The IgM/IgG positive samples were further tested for IgG avidity...
September 6, 2016: Wiener Klinische Wochenschrift
Ayşe Düzbeyaz, Nermin Şakru, Seray Töz
OBJECTIVE: In this study, we aimed to investigate the seroprevalence of canine leishmaniosis among dogs that live in the town center due to a lack of data on the prevalence of canine leishmaniasis (CanL) in Edirne. METHODS: In the present study, 37 dogs living in a municipal dog and cat shelter in Edirne were screened for leishmaniosis by the ındirect fluorescent antibody test. RESULTS: All samples were found to be seronegative. CONCLUSION: Our study is a preliminary study for Edirne...
June 2016: Türkiye Parazitolojii Dergisi
Cosme Alvarado-Esquivel, Jesus Hernandez-Tinoco, Luis Francisco Sanchez-Anguiano, Agar Ramos-Nevarez, Sandra Margarita Cerrillo-Soto, Jose Manuel Salas-Pacheco, Ada Agustina Sandoval-Carrillo, Lucio Martinez-Ramirez, Elizabeth Irasema Antuna-Salcido, Carlos Alberto Guido-Arreola
BACKGROUND: The seroepidemiology of rubella virus infection in pregnant women in northern Mexico is largely unknown. We sought to determine the seroprevalence of rubella virus infection in pregnant women in the northern Mexican city of Durango, Mexico. Seroprevalence association with the socio-demographic, clinical and behavioral characteristics of the pregnant women was also investigated. METHODS: Through a cross-sectional study, we determined the seroprevalence of IgG and IgM anti-rubella virus in 279 pregnant women (mean age 29...
September 2016: Journal of Clinical Medicine Research
Margaretha A Vink, Johannes Berkhof, Jan van de Kassteele, Michiel van Boven, Johannes A Bogaards
Post-vaccine monitoring programs for human papillomavirus (HPV) have been introduced in many countries, but HPV serology is still an underutilized tool, partly owing to the weak antibody response to HPV infection. Changes in antibody levels among non-vaccinated individuals could be employed to monitor herd effects of immunization against HPV vaccine types 16 and 18, but inference requires an appropriate statistical model. The authors developed a four-component bivariate mixture model for jointly estimating vaccine-type seroprevalence from correlated antibody responses against HPV16 and -18 infections...
2016: PloS One
Amitis Ramezani, Elham Saboori, Kayhan Azadmanesh, Minoo Mohraz, Monireh Kazemimanesh, Afsaneh Karami, Mohammad Banifazl, Hanieh Golchehregan, Arezoo Aghakhani
BACKGROUND: Kaposi's sarcoma is a vascular malignancy, which frequently occurs among immunocompromised individuals such as transplant recipients and patients with acquired immunodeficiency syndrome. Human herpesvirus 8 (HHV-8) is considered the etiological agent of all forms of Kaposi's sarcoma. Though some seroepidemiological studies conducted on the prevalence of HHV-8 in Iran, there are insufficient data on the prevalence of HHV-8 viremia in HIV infected patients. We therefore, aimed to determine the prevalence of HHV-8 viremia in general population and HIV infected patients without Kaposi's sarcoma in Tehran, Iran...
July 2016: Iranian Journal of Public Health
Vrushali Patwardhan, Preena Bhalla
INTRODUCTION: Type-specific serology (TSS) test for herpes simplex virus (HSV) have been used as a research tool in seroepidemiological studies for some years. However, TSS as a diagnostic modality for diagnosis of current episode of genital herpes is not well documented. AIMS AND OBJECTIVES: To measure the seroprevalence of type-specific HSV Type 1 (HSV-1) and Type 2 (HSV-2) IgG antibodies in cases provisionally diagnosed as primary and recurrent genital herpes and to evaluate the role of TSS as a diagnostic modality for diagnosis of genital herpes versus polymerase chain reaction (PCR)...
July 2016: Indian Journal of Pathology & Microbiology
Cosme Alvarado-Esquivel, Luis Francisco Sánchez-Anguiano, Jesús Hernández-Tinoco, Agar Ramos-Nevárez, Sandra Margarita Cerrillo-Soto, Carlos Alberto Guido-Arreola
The seroepidemiology of Leptospira infection in patients suffering from liver disease has been poorly studied. Information about risk factors associated with infection in liver disease patients may help in the optimal planning of preventive measures. We sought to determine the association of Leptospira IgG seroprevalence and patients with liver diseases, and to determine the characteristics of the patients with Leptospira exposure. We performed a case-control study of 75 patients suffering from liver diseases and 150 age- and gender-matched control subjects...
June 2016: International Journal of Biomedical Science: IJBS
Petra J Woestenberg, Jeroen H T Tjhie, Hester E de Melker, Fiona R M van der Klis, Jan E A M van Bergen, Marianne A B van der Sande, Birgit H B van Benthem
BACKGROUND: Genital herpes results in considerable morbidity, including risk of neonatal herpes, and is increasingly being caused by Herpes Simplex Virus (HSV) type 1. Possibly children are less often HSV-1 infected, leaving them susceptible until sexual debut. We assessed changes in the Dutch HSV-1 and HSV-2 seroprevalence over time and determinants associated with HSV seropositivity. METHODS: We used data from two population-based seroepidemiological studies conducted in 1995-6 and 2006-7 with a similar study design...
2016: BMC Infectious Diseases
Daisuke Hayasaka, Yu Fuxun, Akira Yoshikawa, Guillermo Posadas-Herrera, Satoshi Shimada, Mya Myat Ngwe Tun, Masanobu Agoh, Kouichi Morita
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease in East Asia. It is thought that the SFTS virus (SFTSV) circulates between ticks and animals in nature and that the virus is transmitted to humans by tick bites. SFTS is endemic to Nagasaki in western Japan; however, epidemiological information regarding SFTSV in Nagasaki is not known. In this study, we performed SFTSV IgG ELISAs and neutralization antibody assays for a seroepidemiological survey using samples from wild boars captured in six areas of Nagasaki...
2016: Tropical Medicine and Health
Suvi Lappalainen, Vesna Blazevic, Maria Malm, Timo Vesikari
Rotavirus (RV) is the leading cause of severe gastroenteritis (GE) in young children, but RVGE has drastically been reduced with the introduction of live oral RV vaccines into childhood immunization program in many countries. Serum IgA antibody is a marker of clinical protection against severe RVGE after RV infection and vaccination. This study investigated VP6-specificity of anti-RV IgA antibody levels in Finnish children aged 6-23 months before and after introduction of RotaTeq® into national immunization program...
July 19, 2016: Journal of Medical Virology
Cosme Alvarado-Esquivel, Luis Francisco Sánchez-Anguiano, Jesús Hernández-Tinoco, Rosa Angélica Pulido-Montoya, Guadalupe Acosta-Rojas, Sergio Estrada-Martínez, Alma Rosa Pérez-Álamos, Raquel Vaquera-Enriquez, Arturo Díaz-Herrera, Raúl Segura-Moreno, María de Lourdes Guerrero-Carbajal, Oliver Liesenfeld, Isabel Beristain García, María Guadalupe Rentería-López
Medical certificates are documents that state the health status of a person. This study aimed to determine the seroprevalence and risk factors for Toxoplasma gondii infection in applicants of medical certificates and to investigate seroprevalence association with characteristics of these individuals. We examined 404 applicants in a public health center in Durango City, Mexico for the presence of anti-Toxoplasma IgG and IgM antibodies using enzyme-linked immunoassays. Of the 404 subjects (mean age of 35.94 ± 13...
June 24, 2016: European Journal of Microbiology & Immunology
Peter W Horby, Karen L Laurie, Benjamin J Cowling, Othmar G Engelhardt, Katharine Sturm-Ramirez, Jose L Sanchez, Jacqueline M Katz, Timothy M Uyeki, John Wood, Maria D Van Kerkhove
BACKGROUND: Population-based serologic studies are a vital tool for understanding the epidemiology of influenza and other respiratory viruses, including the early assessment of the transmissibility and severity of the 2009 influenza pandemic, and Middle East respiratory syndrome coronavirus. However, interpretation of the results of serologic studies has been hampered by the diversity of approaches and the lack of standardized methods and reporting. OBJECTIVE: The objective of the CONSISE ROSES-I statement was to improve the quality and transparency of reporting of influenza seroepidemiologic studies and facilitate the assessment of the validity and generalizability of published results...
July 15, 2016: Influenza and Other Respiratory Viruses
Jung Wook Park, Jae Keun Chung, Sun Hee Kim, Sun Ju Cho, Yi Deun Ha, So Hyang Jung, Hye Jung Park, Hyun Jae Song, Jung Yoon Lee, Dong Min Kim, Jah Pyus, Dong Ryong Ha, Eun Sun Kim, Jae Il Lee
Serosurveillance for zoonotic diseases in small mammals and detection of chiggers, the vector of Orientia tsutsugamushi, were conducted from September 2014 to August 2015 in Gwangju Metropolitan Area. Apodemus agrarius was the most commonly collected small mammals (158; 91.8%), followed by Myodes regulus (8; 4.6%), and Crocidura lasiura (6; 3.5%). The highest seroprevalence of small mammals for O. tsutsugamushi (41; 26.3%) was followed by hantaviruses (24; 15.4%), Rickettsia spp. (22; 14.1%), and Leptospira (2; 1...
June 2016: Korean Journal of Parasitology
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