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REVIEW
Ming-Hui Zhu, Yan-Jun Liu, Chang-Yun Li, Fan Tao, Guan-Jun Yang, Jiong Chen
Leukocyte cell-derived chemotaxin-2 (LECT2, also named ChM-II), initially identified as a chemokine mediating neutrophil migration, is a multifunctional secreted factor involved in diverse physiological and pathological processes. The high sequence similarity of LECT2 among different vertebrates makes it possible to explore its functions by using comparative biology. LECT2 is associated with many immune processes and immune-related diseases via its binding to cell surface receptors such as CD209a, Tie1, and Met in various cell types...
2023: Frontiers in Immunology
#22
JOURNAL ARTICLE
Mateusz Nowicki, Agnieszka Wierzbowska, Bożena Szymańska, Grzegorz Nowicki, Anna Szmigielska-Kapło
Mobilization of CD34+ cells is a key element in the therapy of patients with multiple myeloma undergoing autologous stem cell transplantation. The use of chemotherapy and the granulocyte colony-stimulating factor can significantly affect the expression of inflammation-related proteins and the migration of hematopoietic stem cells. We assessed the mRNA expression of selected proteins involved in the inflammatory landscape in MM patients (n=71). The aim of the study was to evaluate C-C motif chemokine ligand 3, 4, 5 (CCL3, CCL4, CCL5), leukocyte cell-derived chemotaxin 2 (LECT2), tumor necrosis factor (TNF), and formyl peptide receptor 2 (FPR2) levels in the course of mobilization and their role in the CD34+ collection efficacy...
March 9, 2023: Experimental Hematology
#23
JOURNAL ARTICLE
Sundus Malaikah, Scott A Willis, Joseph Henson, Jack A Sargeant, Thomas Yates, Alice E Thackray, Fernanda R Goltz, Matthew Roberts, Danielle Bernard-Deshong, Guruprasad P Aithal, David J Stensel, James A King
Leukocyte cell-derived chemotaxin-2 (LECT2) and fibroblast growth factor 21 (FGF21) are hepatokines which are regulated by energy balance and mediate insulin sensitivity and glycaemic control. This cross-sectional study examined the independent associations of cardiorespiratory fitness (CRF), moderate-to-vigorous intensity physical activity (MVPA), and sedentary time, with circulating LECT2 and FGF21. Data were combined from two previous experimental studies in healthy volunteers (n=141, male=60%, mean ± SD age=37 ± 19 years, body mass index (BMI)=26...
March 3, 2023: Applied Physiology Nutrition and Metabolism
#24
Logan S Richards, Maria D Flores, Samantha Zink, Natalie A Schibrowsky, Michael R Sawaya, Jose A Rodriguez
ALECT2 is a type of systemic amyloidosis caused by deposition of the leukocyte cell-derived chemotaxin-2 (LECT2) protein in the form of fibrils. In ALECT2, LECT2 fibril deposits can be found in the glomerulus, resulting in renal failure. Affected patients lack effective treatment options outside of renal transplant or dialysis. While the structure of LECT2 in its globular form has been determined by X-ray crystallography, structures of LECT2 amyloid fibrils remain unknown. Using single particle cryo-EM, we now find that human LECT2 forms robust twisting fibrils with canonical amyloid features...
February 11, 2023: bioRxiv
#25
JOURNAL ARTICLE
Xiaofen Zhang, Kefang Sun, Chenxi Tang, Li Cen, Sha Li, Wei Zhu, Peihao Liu, Yishu Chen, Chaohui Yu, Lan Li
BACKGROUND: Helicobacter pylori (H. pylori), a gram-negative bacterium persisting on the gastric mucosa, is involved in the pathogenesis of a variety of gastric diseases. Leukocyte cell-derived chemotaxin 2 (LECT2) treatment increased the phagocytic capacity of lymphocytes and improved immune function in bacterial infection. Whether the immune cells infected with Helicobacter pylori (H. pylori) are affected by LECT2 is unclear. METHODS: Bone marrow-derived dendritic cells (BMDCs) from wild-type C57BL/6 mice, CD209a knockout mice or LECT2 knockout mice were exposed to H...
February 5, 2023: Journal of Gastroenterology and Hepatology
#26
JOURNAL ARTICLE
Yue Gao, Shicheng Fan, Pengfei Zhao, Huilin Li, Chenghui Cai, Xuan Li, Yanying Zhou, Min Huang, Huichang Bi
Liver fibrosis can be characterized by the over-deposition of extracellular matrix (ECM). It has been reported that β-catenin/TCF4 interaction was enhanced in bile duct ligation (BDL) model, which implicated the critical role of β-catenin/TCF4 interaction during the progression of fibrosis. However, whether inhibiting β-catenin/TCF4 signaling attenuates liver fibrosis remains unknown. In the current study, we used ICG-001, an inhibitor that disrupts the interaction between CREB binding protein (CBP) and β-catenin, to inhibit β-catenin/TCF4 transcriptional activity...
January 10, 2023: Chemico-biological Interactions
#27
JOURNAL ARTICLE
Yuan Xie, Ke-Bo Zhong, Yang Hu, Yong-Lun Xi, Shi-Xing Guan, Meng Xu, Yuan Lin, Feng-Yong Liu, Wei-Jie Zhou, Yi Gao
BACKGROUND: Immune cells, including neutrophils, natural killer (NK) cells, T cells, NKT cells and macrophages, participate in the progression of acute liver injury and hepatic recovery. To date, there has been no systematic study on the quantitative changes in these different immune cells from initial injury to subsequent recovery. AIM: To investigate the infiltration changes of various immune cells in acute liver injury models over time, and to study the relationship between the changes in leukocyte cell-derived chemotaxin 2 (LECT2) and the infiltration of several immune cells...
December 14, 2022: World Journal of Gastroenterology: WJG
#28
JOURNAL ARTICLE
Kristin L Young, Virginia Fisher, Xuan Deng, Jennifer A Brody, Misa Graff, Elise Lim, Bridget M Lin, Hanfei Xu, Najaf Amin, Ping An, Stella Aslibekyan, Alison E Fohner, Bertha Hidalgo, Petra Lenzini, Robert Kraaij, Carolina Medina-Gomez, Ivana Prokić, Fernando Rivadeneira, Colleen Sitlani, Ran Tao, Jeroen van Rooij, Di Zhang, Jai G Broome, Erin J Buth, Benjamin D Heavner, Deepti Jain, Albert V Smith, Kathleen Barnes, Meher Preethi Boorgula, Sameer Chavan, Dawood Darbar, Mariza De Andrade, Xiuqing Guo, Jeffrey Haessler, Marguerite R Irvin, Rita R Kalyani, Sharon L R Kardia, Charles Kooperberg, Wonji Kim, Rasika A Mathias, Merry-Lynn McDonald, Braxton D Mitchell, Patricia A Peyser, Elizabeth A Regan, Susan Redline, Alexander P Reiner, Stephen S Rich, Jerome I Rotter, Jennifer A Smith, Scott Weiss, Kerri L Wiggins, Lisa R Yanek, Donna Arnett, Nancy L Heard-Costa, Suzanne Leal, Danyu Lin, Barbara McKnight, Michael Province, Cornelia M van Duijn, Kari E North, L Adrienne Cupples, Ching-Ti Liu
Anthropometric traits, measuring body size and shape, are highly heritable and significant clinical risk factors for cardiometabolic disorders. These traits have been extensively studied in genome-wide association studies (GWASs), with hundreds of genome-wide significant loci identified. We performed a whole-exome sequence analysis of the genetics of height, body mass index (BMI) and waist/hip ratio (WHR). We meta-analyzed single-variant and gene-based associations of whole-exome sequence variation with height, BMI, and WHR in up to 22,004 individuals, and we assessed replication of our findings in up to 16,418 individuals from 10 independent cohorts from Trans-Omics for Precision Medicine (TOPMed)...
January 12, 2023: HGG advances
#29
JOURNAL ARTICLE
Mercedes A de la Cruz Jasso, Juan M Mejía-Vilet, Noemí Del Toro-Cisneros, Diana E Aguilar-León, Luis E Morales-Buenrostro, Guillermo Herrera, Norma O Uribe-Uribe
OBJECTIVES: To assess the prevalence of leukocyte cell-derived chemotactic 2 (LECT2), its organ involvement, and its clinical association in autopsies from an ethnically biased population. METHODS: The tissues from all autopsies of individuals diagnosed with amyloidosis were reassessed and typed for amyloid light chain (AL) amyloidosis, amyloid A (AA) amyloidosis, transthyretin amyloidosis (ATTR), and leukocyte chemotactic factor 2 amyloidosis (ALECT2) by immunohistochemistry...
November 12, 2022: American Journal of Clinical Pathology
#30
JOURNAL ARTICLE
Jiangfeng Qin, Weijie Sun, Hui Zhang, Zihao Wu, Jiapei Shen, Wenhai Wang, Yuanyuan Wei, Yanyan Liu, Yufeng Gao, Honghai Xu
Background: Previous studies have shown that Leukocyte cell-derived chemotaxin2 (LECT2) is associated with the development of HCC. However, there are still no studies with a comprehensive analysis of the role of LECT2 in hepatocellular carcinoma (HCC). Methods: TCGA data sets were used to analyze the expression of LECT2 in HCC. In addition, the prognostic value of LECT2 in HCC was also investigated. DriverDBv3 was used to analyze the Mutation, CNV, and methylation profiles of LECT2. And, validated by immunohistochemistry in 72 HCC samples...
2022: Frontiers in Genetics
#31
Shuang Wang, Xiao-Juan Yu, Dan-Yang Li, Jin Xu, Su-Xia Wang
Leukocyte chemotactic factor 2-associated (ALECT2) amyloidosis is one of the recently reported types of amyloidosis, which is caused by the extracellular deposition of leukocyte chemotactic factor 2 (LECT2). There have not been any reports involving the concurrence of ALECT2 amyloidosis with Sjögren's syndrome (SS) or systemic lupus erythematosus (SLE)s. Herein, we report a case of a 68-year-old Chinese woman presenting with long duration of sicca symptoms. The clinical evaluation and laboratory findings showed that she had SS overlapped with SLE...
2022: Frontiers in Immunology
#32
JOURNAL ARTICLE
Tian-Huei Chu, Chou-Yuan Ko, Po-Han Tai, Yi-Chen Chang, Chao-Cheng Huang, Tung-Yang Wu, Hoi-Hung Chan, Ping-Hsuan Wu, Chien-Hui Weng, Yu-Wei Lin, Mei-Lang Kung, Cheng-Chieh Fang, Jian-Ching Wu, Zhi-Hong Wen, Yung-Kuo Lee, Tsung-Hui Hu, Ming-Hong Tai
Leukocyte cell-derived chemotaxin 2 (LECT2) acts as a tumor suppressor in hepatocellular carcinoma (HCC). However, the anti-neoplastic mechanism of LECT2, especially its influence on hepatic cancer stem cells (CSCs), remains largely unknown. In The Cancer Genome Atlas (TCGA) cohort, LECT2 mRNA expression was shown to be associated with stage, grade, recurrence, and overall survival in human HCC patients, and LECT2 expression was downregulated in hepatoma tissues compared with the adjacent non-tumoral liver...
August 30, 2022: Journal of Biological Chemistry
#33
JOURNAL ARTICLE
A J Gallan, B Bhasin-Chhabra, D Kilari, S Johnson, A D'Souza
Pathologic evaluation of the non-neoplastic renal parenchyma in tumor nephrectomy specimens is critical and can detect both renal-limited and systemic pathologies. We report the case of a 69-year-old Punjabi male who underwent cytoreductive nephrectomy for advanced renal cell carcinoma after immunotherapy. We detected clinically unexpected leukocyte chemotactic factor 2 (LECT2) amyloidosis during pathologic analysis of the surrounding non-neoplastic renal parenchyma, which was confirmed by mass spectrometry...
August 20, 2022: CEN Case Reports
#34
JOURNAL ARTICLE
Qiang Wang, Feng Xu, Jiong Chen, Yan-Qing Xie, Su-Ling Xu, Wen-Ming He
OBJECTIVE: The aim of this study was to examine serum leukocyte cell-derived chemotaxin 2 (LECT2) levels in osteoporosis subjects to confirm its association with osteoporosis. METHODS: A total of 204 adult subjects were recruited. Bone mineral densities (BMD) were assessed and blood samples were collected for measurements of biomedical parameters and the bone turnover markers. Serum LECT2 levels were measured by enzyme-linked immunosorbent assay. The relationships between serum LECT2 levels and other parameters were analyzed using the Spearman correlation coefficient...
August 17, 2022: Laboratory Medicine
#35
JOURNAL ARTICLE
Jinfeng Zhao, Xiaodan Xu, Qingyun Gou, Qipeng Zheng, Liang Ge, Lingzhi Chen, Cong Zhang, Hui Ma, Shuxiang Lin, Xiaoli Hu, Jianghua Zhan
Objective: Biliary atresia (BA) presents as a severe infantile cholangiopathy disease, characterized by progressive liver fibrosis and the resulting poor prognosis. Leukocyte cell-derived chemotaxin 2 (LECT2) was proposed as the key gene associated with hepatic fibrosis in BA, but the molecular mechanism is unclear. This study aims to investigate the function of LECT2 in BA. Methods: A total of 53 patients were enrolled in this study; 36 patients with BA, and 17 control patients with cholestasis, including congenital biliary dilations, biliary hypoplasia, and inspissated bile syndrome...
2022: Frontiers in Pediatrics
#36
JOURNAL ARTICLE
Hongzhao Xu, Ye Jia, Xueyao Wang, Hui Wang, Jinyu Yu, Wu Hao
RATIONALE: Amyloidogenic leukocyte chemotactic factor 2 (ALECT2) was recently considered as a new clinicopathologic type of amyloid, which frequently affects kidney in adults and results in different degrees of renal insufficiency and failure with or without proteinuria. Here, we present a case of combining LECT2-associated renal amyloidosis with immunoglobulin (Ig)A nephropathy. PATIENT CONCERNS: A 71-year-old Chinese man presented with edema of both lower extremities...
July 22, 2022: Medicine (Baltimore)
#37
JOURNAL ARTICLE
Jimin Kim, Seul Ki Lee, Donguk Kim, Eunyoung Lee, Chan Yoon Park, Han Choe, Min-Ji Kang, Hwa Jung Kim, Jong-Hyeok Kim, Joon Pio Hong, Yeon Ji Lee, Hye Soon Park, Yoonseok Heo, Yeon Jin Jang
OBJECTIVE: Leukocyte cell-derived chemotaxin 2 (LECT2) is an obesity-upregulated hepatokine inducing skeletal muscle insulin resistance. The study's aim was to explore whether LECT2 is expressed in human adipose tissue and whether the expression is dysregulated during obesity and associated with obesity-related metabolic disorders. METHODS: This study measured metabolic parameters, serum LECT2, and expression of LECT2 and CD209, a gene encoding a putative receptor for LECT2, in abdominal subcutaneous and visceral adipose tissues in women with obesity (with or without type 2 diabetes) and women with normal weight...
June 20, 2022: Obesity
#38
JOURNAL ARTICLE
Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET.
Takayoshi Shirasaki, Satoshi Yamagoe, Tetsuro Shimakami, Kazuhisa Murai, Ryu Imamura, Kiyo-Aki Ishii, Hiroaki Takayama, Yukako Matsumoto, Natsumi Tajima-Shirasaki, Naoto Nagata, Ryogo Shimizu, Souma Yamanaka, Atsushi Abe, Hitoshi Omura, Kazunori Kawaguchi, Hikari Okada, Taro Yamashita, Tomoki Yoshikawa, Kazuhiro Takimoto, Motoko Taharaguchi, Shogo Takatsuka, Yoshitsugu Miyazaki, Toshikatsu Tamai, Yamato Tanabe, Makoto Kurachi, Yasuhiko Yamamoto, Shuichi Kaneko, Kunio Matsumoto, Toshinari Takamura, Masao Honda
Retinoic acid-inducible gene (RIG)-I is an essential innate immune sensor that recognises pathogen RNAs and induces interferon (IFN) production. However, little is known about how host proteins regulate RIG-I activation. Here, we show that leukocyte cell-derived chemotaxin 2 (LECT2), a hepatokine and ligand of the MET receptor tyrosine kinase is an antiviral regulator that promotes the RIG-I-mediated innate immune response. Upon binding to MET, LECT2 induces the recruitment of the phosphatase PTP4A1 to MET and facilitates the dissociation and dephosphorylation of phosphorylated SHP2 from MET, thereby protecting RIG-I from SHP2/c-Cbl-mediated degradation...
June 8, 2022: Nature Communications
#39
REVIEW
Yuan Xie, Kai-Wei Fan, Shi-Xing Guan, Yang Hu, Yi Gao, Wei-Jie Zhou
LECT2 (leucocyte cell-derived chemotaxin 2) is a 16-kDa protein mainly produced by hepatocytes. It was first isolated in PHA-activated human T-cell leukaemia SKW-3 cells and originally identified as a novel neutrophil chemotactic factor. However, many lines of studies suggested that LECT2 was a pleiotropic protein, it not only functioned as a cytokine to exhibit chemotactic property, but also played multifunctional roles in some physiological conditions and pathological abnormalities, involving liver regeneration, neuronal development, HSC(haematopoietic stem cells) homeostasis, liver injury, liver fibrosis, hepatocellular carcinoma, metabolic disorders, inflammatory arthritides, systemic sepsis and systemic amyloidosis...
June 3, 2022: Journal of Cellular and Molecular Medicine
#40
Zhen-Yu Li, Shuang Wang, Dan-Yang Li, Dan Liu, Su-Xia Wang, Xiao-Juan Yu, Gang Liu, Fu-De Zhou, Ming-Hui Zhao
Objectives: Fibrinogen A alpha-chain amyloidosis (AFib amyloidosis) is the most common form of hereditary renal amyloidosis in the United Kingdom and Europe, but has rarely been reported in Asia. In this study, we reported two AFib amyloidosis patients in China, reviewing the literature and summarizing main characteristics of AFib amyloidosis in Asia. Methods: Two unrelated Chinese patients were diagnosed with AFib amyloidosis by clinical presentation, renal biopsy, mass spectrometry and DNA sequencing in Peking University First Hospital of China from 2014 to 2016...
2022: Frontiers in Medicine
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