keyword
https://read.qxmd.com/read/38471695/assessing-silver-nanoparticle-and-antimicrobial-combinations-for-antibacterial-activity-and-biofilm-prevention-on-surgical-sutures
#21
JOURNAL ARTICLE
Diana K Al-Sawarees, Rula M Darwish, Rund Abu-Zurayk, Mahmoud Al Masri
AIMS: To evaluate the effect of silver nanoparticles alone and in combination with Triclosan, and trans-cinnamaldehyde against S.aureus and E.coli biofilms on sutures to improve patients' outcomes. METHODS AND RESULTS: Silver nanoparticles were prepared by chemical method and characterized by UV-visible spectrophotometer and dynamic light scattering. The minimum inhibitory concentration was assessed by the Microdilution assay. The antibiofilm activity was determined using crystal violet assay...
March 12, 2024: Journal of Applied Microbiology
https://read.qxmd.com/read/38470435/add-on-erythropoietin-in-autoimmune-hemolytic-anemia
#22
EDITORIAL
Miriam M Moser, Bernd Jilma
No abstract text is available yet for this article.
March 12, 2024: Blood Advances
https://read.qxmd.com/read/38469805/appropriateness-of-use-of-streptococcal-pharyngitis-testing-and-associated-antibiotic-prescribing-in-the-urgent-care-setting
#23
JOURNAL ARTICLE
Michael A Haynes, M'hamed Temkit, Igor Kushner, Diane E Hindman
The primary objective was to evaluate Group A streptococcal (GAS) tests performed with a Modified Centor Criteria (MCC) Score < 3 at Urgent Care Clinics (UCC). Secondary objectives included evaluating the MCC sensitivity and specificity, antibiotics prescribed with an MCC score < 3, and association between palatal petechiae and GAS pharyngitis infections. This was a retrospective review from July 1, 2018, to June 30, 2019, of Rapid Antigen Detection Tests (RADTs) on patients with ICD codes associated with pharyngitis...
March 12, 2024: Clinical Pediatrics
https://read.qxmd.com/read/38469770/establishment-and-validation-of-a-mouse-bacterial-vaginosis-model
#24
JOURNAL ARTICLE
Qiaoni Zhang, Qili Chen, Huixia Lu
BACKGROUND: Bacterial vaginosis (BV) is a common vaginal infection without a reliable animal model. To establish a novel mouse BV model, we evaluated multiple parameters of various identified bacteria-infected mice, including Staphylococcus aureus (SA), Escherichia coli (EC), Streptococcus agalactiae, β-Hemolytic streptococcus, and Gardnerella vaginalis (GV). METHODS: Mature female KM mice were randomly allocated to a vehicle group (group A, without any treatment) and experimental groups...
March 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38468962/3d-printed-polycaprolactone-%C3%AE-tricalcium-phosphate-carbon-nanotube-composite-physical-properties-and-biocompatibility
#25
JOURNAL ARTICLE
Yuelei Wang, Chenjing Liu, Tao Song, Zhenlu Cao, Ting Wang
Three-dimensional (3D) printing is a bio-fabrication technique used to process tissue-engineered scaffolds for bone repair and remodeling. Polycaprolactone (PCL)/β-tricalcium phosphate (TCP) has been used as a base and osteoconductive biomaterial for bone tissue engineering in the past decades. The current study reveals the fabrication of a polycaprolactone (PCL)/β-tricalcium phosphate (TCP) scaffold by incorporating carbon nanotubes (CNT) via 3D printing. The physical properties and cytocompatibility of a new type of tissue engineering composite from polycaprolactone/β-tri-calcium phosphate/carbon nanotubes were investigated, and it was an absorbable scaffold prepared via furnace deposition 3D printing technology...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38468700/the-interactions-between-ineffective-erythropoiesis-and-ferroptosis-in-%C3%AE-thalassemia
#26
REVIEW
Siyang Lin, Yanping Zheng, Meihuan Chen, Liangpu Xu, Hailong Huang
In Guangxi, Hainan, and Fujian Province in southern China, β-thalassemia is a frequent monogenic hereditary disorder that is primarily defined by hemolytic anemia brought on by inefficient erythropoiesis. It has been found that ineffective erythropoiesis in β-thalassemia is closely associated with a high accumulation of Reactive oxygen species, a product of oxidative stress, in erythroid cells. During recent years, ferroptosis is an iron-dependent lipid peroxidation that involves abnormalities in lipid and iron metabolism as well as reactive oxygen species homeostasis...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38467553/synthesis-and-biological-properties-of-polyphenol-containing-linear-and-dendrimeric-cationic-peptides
#27
JOURNAL ARTICLE
Artem A Shatilov, Sergey M Andreev, Anastasiya V Shatilova, Evgeny A Turetskiy, Renata A Kurmasheva, Marina O Babikhina, Larisa V Saprygina, Nadezhda N Shershakova, Dar'ya K Bolyakina, Valeriy V Smirnov, Igor P Shilovsky, Musa R Khaitov
Natural polyphenols are promising compounds for the pharmacological control of oxidative stress in various diseases. However, low bioavailability and rapid metabolism of polyphenols in a form of glycosides or aglycones have stimulated the search for the vehicles that would provide their efficient delivery to the systemic circulation. Conjugation of polyphenols with cationic amphiphilic peptides yields compounds with a strong antioxidant activity and ability to pass through biological barriers. Due to a broad range of biological activities characteristic of polyphenols and peptides, their conjugates can be used in the antioxidant therapy, including the treatment of viral, oncological, and neurodegenerative diseases...
January 2024: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38467020/structure-function-analysis-of-the-a1-subunit-of-shiga-toxin-2-with-peptides-that-target-the-p-stalk-binding-site-and-inhibit-activity
#28
JOURNAL ARTICLE
Xiao-Ping Li, Michael J Rudolph, Yang Chen, Nilgun E Tumer
Shiga toxin 2a (Stx2a) is the virulence factor of Escherichia coli (STEC), which is associated with hemolytic uremic syndrome, the leading cause of pediatric kidney failure. The A1 subunit of Stx2a (Stx2A1) binds to the conserved C-terminal domain (CTD) of the ribosomal P-stalk proteins to remove an adenine from the sarcin-ricin loop (SRL) in the 28S rRNA, inhibiting protein synthesis. There are no antidotes against Stx2a or any other ribosome-inactivating protein (RIP). The structural and functional details of the binding of Stx2A1 to the P-stalk CTD are not known...
March 11, 2024: Biochemistry
https://read.qxmd.com/read/38466192/what-came-first-atypical-hemolytic-uremic-syndrome-or-malignant-hypertension-a-clinical-dilemma
#29
JOURNAL ARTICLE
Sidharth Kumar Sethi, Savita S, Aishwarya Nair, Kritika Soni, Shyam Bihari Bansal, Abhyuday S Rana, Rupesh Raina
No abstract text is available yet for this article.
December 2024: Renal Failure
https://read.qxmd.com/read/38466160/development-and-characterization-of-plant-derived-aristatoside-c-and-davisianoside-b-saponin-loaded-phytosomes-with-suppressed-hemolytic-activity
#30
JOURNAL ARTICLE
Sebnem Ercelen, Bunyamin Bulkurcuoglu, Mustafa Oksuz, Ayse Nalbantsoy, Nazli Boke Sarikahya
Saponins are glycosides widely distributed in the plant kingdom and have many pharmacological activities. However, their tendency to bind to cell membranes can cause cell rupture, limiting their clinical use. In the previous study, aristatoside C and davisianoside B were isolated from Cephalaria species. Cytotoxicity assays showed that they are more active on A-549 cell lines than doxorubicin but caused hemolysis. In the current research, aristatoside C and davisianoside B were loaded to phytosomes called ALPs and DLPs respectively, and characterized for particle size, zeta potential, encapsulation efficiency, release kinetic, hemolytic activity, and cytotoxicity on A-549 cell line...
March 11, 2024: ChemistryOpen
https://read.qxmd.com/read/38463905/public-health-risks-of-raw-milk-consumption-lessons-from-a-case-of-paediatric-hemolytic-uremic-syndrome
#31
JOURNAL ARTICLE
Angela Silveira, Julia Pinheiro Carvalho, Lawrence Loh, Michael Benusic
Pasteurization of raw milk is mandatory before sale in Canada and has been demonstrated to reduce the risk of food-borne illness associated with milk consumption. Consumption of raw milk sparks urgent concern from a public health perspective since it has been linked to numerous outbreaks by enteric organisms, particularly Escherichia coli- related illnesses and complications in pediatric populations. The sale and distribution of raw milk is illegal in Canada, based on these significant health risks, but growing popular interest and trends in consuming raw dairy products reflect changes in consumer preferences...
September 1, 2023: Canada Communicable Disease Report
https://read.qxmd.com/read/38462030/study-of-the-antigenic-characteristics-of-red-blood-cells-units-and-their-sickle-cell-disease-recipients-and-the-g6pd-activity-of-transfused-red-blood-cells-units
#32
JOURNAL ARTICLE
Morgane Le Gallo, Stéphane Moutereau, Mélanie Gentil, France Pirenne
INTRODUCTION: Transfusion has a central place in the treatment of patients with sickle cell disease (SCD). Matching blood groups of red blood cell (RBC) units with the blood groups of the patient is essential to prevent alloimmunization and delayed hemolytic transfusion reaction. African ancestry donors have the best phenocompatibility with patients of the same origin, however their RBCs may present characteristic that can alter quality of the unit such as glucose-6-phosphate dehydrogenase (G6PD) deficiency...
March 8, 2024: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://read.qxmd.com/read/38461065/the-complement-system-in-the-pathogenesis-and-progression-of-kidney-diseases-what-doesn-t-kill-you-makes-you-older
#33
REVIEW
Emma Diletta Stea, Giuseppina D'Ettorre, Adele Mitrotti, Loreto Gesualdo
The Complement System is an evolutionarily conserved component of immunity that plays a key role in host defense against infections and tissue homeostasis. However, the dysfunction of the Complement System can result in tissue damage and inflammation, thereby contributing to the development and progression of various renal diseases, ranging from atypical Hemolytic Uremic Syndrome to glomerulonephritis. Therapeutic interventions targeting the complement system have demonstrated promising results in both preclinical and clinical studies...
March 8, 2024: European Journal of Internal Medicine
https://read.qxmd.com/read/38460770/polydispersity-mediated-high-efficacy-of-an-in-situ-aqueous-nanosuspension-of-ppef-3hcl-in-methicillin-resistant-staphylococcus-aureus-sepsis-model
#34
JOURNAL ARTICLE
Amit S Lokhande, Vikas Maurya, Komal Rani, Palak Parashar, Rajni Gaind, Vibha Tandon, Padma V Devarajan
Recently, World Health Organization declared antimicrobial resistance as the third greatest threat to human health. Absence of known cross-resistance, new class, new target, and a new mode of action are few major strategies being undertaken by researches to combat multidrug resistant pathogen. PPEF.3HCl, a bisbenzimidazole was developed as highly potent antibacterial agent against ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens, targeting topoisomerase IA...
March 7, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38460482/polypyridyl-ruthenium-complexes-with-benzothiazole-moiety-as-membrane-disruptors-and-anti-resistance-agents-for-staphylococcus-aureus
#35
JOURNAL ARTICLE
Wei Deng, Chun-Yan Zhang, Li-Xin Dou, Li-Ting Huang, Jin-Tiao Wang, Xiang-Wen Liao, Li-Ping Wang, Ru-Jian Yu, Yan-Shi Xiong
Developing new antimicrobials to combat drug-resistant bacterial infections is necessary due to the increasing problem of bacterial resistance. In this study, four metallic ruthenium complexes modified with benzothiazoles were designed, synthesized and subjected to bio-evaluated. Among them, Ru-2 displayed remarkable inhibitory activity against Staphylococcus aureus (S. aureus) with a minimum inhibitory concentration (MIC) of 1.56 μg/mL. Additionally, it showcased low hemolytic toxicity (HC50  > 200 μg/mL) and the ability to effectively eradicate S...
March 5, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38459502/unveiling-biological-activities-of-biosynthesized-starch-silver-selenium-nanocomposite-using-cladosporium-cladosporioides-cbs-174-62
#36
JOURNAL ARTICLE
Fathy M Elkady, Amr H Hashem, Salem S Salem, Gharieb S El-Sayyad, Ahmed Abdel Tawab, Mohammad M Alkherkhisy, Mohammed S Abdulrahman
BACKGROUND AND OBJECTIVES: Microbial cells capability to tolerate the effect of various antimicrobial classes represent a major worldwide health concern. The flexible and multi-components nanocomposites have enhanced physicochemical characters with several improved properties. Thus, different biological activities of biosynthesized starch/silver-selenium nanocomposite (St/Ag-Se NC) were assessed. METHODOLOGY: The St/Ag-Se NC was biosynthesized using Cladosporium cladosporioides CBS 174...
March 8, 2024: BMC Microbiology
https://read.qxmd.com/read/38456915/assessment-of-south-asian-pediatric-acute-kidney-injury-epidemiology-and-risk-factors-aspire-a-prospective-study-on-severe-dialysis-dependent-pediatric-aki
#37
JOURNAL ARTICLE
Sidharth Kumar Sethi, Rupesh Raina, Ahmad Sawan, Sadaf Asim, Aye Kyawt Khant, Manoj Matnani, Kalaivani Ganesan, Shraddha Lohia, Rajiv Sinha, Jubaida Rumana, Syed Saimul Haque, Suprita Kalra, Rabia Safdar, Gopal Prasad, Iftikhar Ijaz, Omer S Ashruf, Aishwarya Nair, Savita S, Kritika Soni, Devendra Shrestha, Shankar Yadav, Asiri Abeyagunawardena, Valerie A Luyckx, Khalid A Alhasan, Azmeri Sultana
BACKGROUND: Pediatric acute kidney injury (AKI) is a global health concern with an associated mortality risk disproportionately pronounced in resource-limited settings. There is a pertinent need to understand the epidemiology of pediatric AKI in vulnerable populations. Here, we proposed a prospective study to investigate the epidemiology and associated risk factors of "severe dialysis dependent AKI" in children among South Asian nations which would be the first and largest of its kind...
March 8, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38455876/developing-international-classification-of-disease-code-definitions-for-the-study-of-enteric-infection-sequelae-in-canada
#38
JOURNAL ARTICLE
Eleni Galanis, Azita Goshtasebi, Yuen Wai Hung, Jonathan Chan, Douglas Matsell, Kristine Chapman, Gilaad Kaplan, David Patrick, Bei Yuan Zhang, Marsha Taylor, Dimitra Panagiotoglou, Shannon Majowicz
BACKGROUND: Enteric infections and their chronic sequelae are a major cause of disability and death. Despite the increasing use of administrative health data in measuring the burden of chronic diseases in the population, there is a lack of validated International Classification of Disease (ICD) code-based case definitions, particularly in the Canadian context. Our objective was to validate ICD code definitions for sequelae of enteric infections in Canada: acute kidney injury (AKI); hemolytic uremic syndrome (HUS); thrombotic thrombocytopenic purpura (TTP); Guillain-Barré syndrome/Miller-Fisher syndrome (GBS/MFS); chronic inflammatory demyelinating polyneuropathy (CIDP); ankylosing spondylitis (AS); reactive arthritis; anterior uveitis; Crohn's disease, ulcerative colitis, celiac disease, erythema nodosum (EN); neonatal listeriosis (NL); and Graves' disease (GD)...
August 1, 2023: Canada Communicable Disease Report
https://read.qxmd.com/read/38452726/structure-modification-of-anoplin-for-fighting-resistant-bacteria
#39
REVIEW
Chao Zhong, Jing Zou, Wenbo Mao, Ping Yang, Jingying Zhang, Sanhu Gou, Yun Zhang, Hui Liu, Jingman Ni
The emergence of bacterial resistance has posed a significant challenge to clinical antimicrobial treatment, rendering commonly used antibiotics ineffective. The development of novel antimicrobial agents and strategies is imperative for the treatment of resistant bacterial infections. Antimicrobial peptides (AMPs) are considered a promising class of antimicrobial agents due to their low propensity for resistance and broad-spectrum activity. Anoplin is a small linear α-helical natural antimicrobial peptide that was isolated from the venom of the solitary wasp Anplius samariensis...
February 24, 2024: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38452173/shiga-toxin-producing-escherichia-coli-testing-in-new-york-2011-2022-reveals-increase-in-non-o157-identifications
#40
JOURNAL ARTICLE
Ashley E Cukrovany, Danielle Wroblewski, Samantha E Wirth, Lisa M Thompson, Amy L Saylors, Julia A Connors, Deborah J Baker, Michelle C Dickinson, Charles E MacGowan, Cyndel Vollmer, Daniel T Woods, Kimberlee A Musser, Lisa A Mingle
Shiga toxin-producing Escherichia coli (STEC) are an important cause of bacterial enteric infection. STEC strains cause serious human gastrointestinal disease, which may result in life-threatening complications such as hemolytic uremic syndrome. They have the potential to impact public health due to diagnostic challenges of identifying non-O157 strains in the clinical laboratory. The Wadsworth Center (WC), the public health laboratory of the New York State Department of Health, has isolated and identified non-O157 STEC for decades...
March 7, 2024: Foodborne Pathogens and Disease
keyword
keyword
52127
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.