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https://www.readbyqxmd.com/read/29678547/pamam-dendrimers-as-a-carbamazepine-delivery-system-for-neurodegenerative-diseases-a-biophysical-and-nanotoxicological-characterization
#1
Daniela E Igartúa, Carolina S Martinez, C Facundo Temprana, Silvia Del V Alonso, M Jimena Prieto
Carbamazepine (CBZ) is an antiepileptic drug, which also could be used in the treatment of neurodegenerative diseases, such as the Alzheimer's disease. However, its use has been limited due to its low solubility, inefficient pharmacokinetic profiles, and multiple side effects. PAMAM dendrimers, ethylenediamine core, generation 4.0 (amine terminal groups) and 4.5 (carboxylate terminal groups) (DG4.0 and DG4.5 respectively) are polymers that can increase drug solubility through complexation. Thus, the aim of this work was to obtain and characterize complexes between CBZ and dendrimers...
April 17, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29678228/analyzing-complement-activity-in-the-serum-and-body-homogenates-of-different-fish-species-using-rabbit-and-sheep-red-blood-cells
#2
Sagar Nayak, Isabel Portugal, Dina Zilberg
Alternative complement activity was determined in whole body homogenates (WBHs) and serum samples of different fish species, by measuring the amount of sample that induces 50% hemolysis of red blood cells using the ACH50 assay (Alternative Complement pathway Hemolytic activity). Values of ACH50 obtained for serum samples were about two-fold higher when using rabbit red blood cells (RRBC), as compared to sheep red blood cells (SRBC). The increase in ACH50 when using RRBCs for WBH samples was 28, 7 and 4 folds for guppy, molly and zebrafish, respectively...
May 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29674195/thrombotic-microangiopathies-of-pregnancy-differential-diagnosis
#3
REVIEW
M Gupta, B B Feinberg, R M Burwick
Thrombotic microangiopathy (TMA) disorders are characterized by microangiopathic hemolytic anemia, thrombocytopenia and end-organ injury. In pregnancy and postpartum, TMA is most commonly encountered with HELLP (hemolysis, elevated liver enzymes, low platelet count syndrome) or preeclampsia with severe features, but rarely TMA is due to thrombotic thrombocytopenic purpura (TTP) or atypical hemolytic uremic syndrome (aHUS). Due to overlapping clinical and laboratory features, TTP and aHUS are often mistaken for preeclampsia or HELLP...
February 16, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29674122/4-fluorobenzaldehyde-limonene-based-thiosemicarbazone-induces-apoptosis-in-pc-3-human-prostate-cancer-cells
#4
Bruna Dos Santos Rodrigues, Renato Ivan de Ávila, Polyana Lopes Benfica, Ludmila Pires Bringel, Cecília Maria Alves de Oliveira, Fábio Vandresen, Cleuza Conceição da Silva, Marize Campos Valadares
AIMS: This study evaluated parameters of toxicity and antiproliferative effects of (+)-N(1)-4-fluorobenzaldehyde-N(4)-{1-methyl-1-[(1R)-4-methylcyclohexene-3-il]-ethyl}-thiossemicarbazone (4-FTSC) in PC-3 adenocarcinoma prostate cells. MAIN METHODS: Cytotoxicity of 4-FTSC in PC-3 cells was evaluated using MTT assay. Morphology examination of PC-3 cells treated with 4-FTSC was also performed as well as the cell death mechanisms induced were investigated using flow cytometry...
April 16, 2018: Life Sciences
https://www.readbyqxmd.com/read/29672023/chitosan-based-peptidopolysaccharides-as-cationic-antimicrobial-agents-and-antibacterial-coatings
#5
Dicky Pranantyo, Li Qun Xu, En-Tang Kang, Mary B Chan-Park
The rapid spread of multidrug resistant bacteria has called for effective antimicrobial agents which work on a more direct mechanism of killing. Cationic peptidopolysaccharides are developed in the present work to mimic the peptidoglycan structure of bacteria and to enhance the membrane-compromising bactericidal efficacy. Antimicrobial CysHHC10 peptide was grafted to the C-2 (amino) or C-6 (hydroxyl) position of chitosan backbone via thiol-maleimide 'click' conjugation, utilizing the maleimidohexanoic linkers...
April 19, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29671499/poststreptococcal-illness-recognition-and-management
#6
David L Maness, Michael Martin, Gregg Mitchell
Group A beta-hemolytic streptococcus can cause several postinfectious, nonsuppurative immune- mediated diseases including acute rheumatic fever, poststreptococcal reactive arthritis, pediatric autoimmune neuropsychiatric disorders, and poststreptococcal glomerulonephritis. Except for sporadic outbreaks, poststreptococcal autoimmune syndromes occur most commonly in sub-Saharan Africa, India, Australia, and New Zealand. Children younger than three years are rarely affected by group A streptococcus pharyngitis or rheumatic fever, and usually do not require testing...
April 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29670616/overactivity-of-alternative-pathway-convertases-in-patients-with-complement-mediated-renal-diseases
#7
Marloes A H M Michels, Nicole C A J van de Kar, Marcin Okrój, Anna M Blom, Sanne A W van Kraaij, Elena B Volokhina, Lambertus P W J van den Heuvel
Overactivation of the alternative pathway of the complement system is associated with the renal diseases atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G). C3 nephritic factors (C3NeF) play an important role in C3G pathogenesis by stabilizing the key enzymatic complex of complement, the C3 convertase. However, the reliability of assays detecting these autoantibodies is limited. Therefore, in this study, we validated and optimized a prototype hemolytic method for robust detection and characterization of factors causing convertase overactivity in large patient cohorts...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29670183/anticoagulant-mechanism-pharmacological-activity-and-assessment-of-preclinical-safety-of-a-novel-fibrin-ogen-olytic-serine-protease-from-leaves-of-leucas-indica
#8
Debananda Gogoi, Neha Arora, Bhargab Kalita, Rahul Sarma, Taufikul Islam, Sidhhartha S Ghosh, Rajlakshmi Devi, Ashis K Mukherjee
The harnessing of medicinal plants containing a plethora of bioactive molecules may lead to the discovery of novel, potent and safe therapeutic agents to treat thrombosis-associated cardiovascular diseases. A 35 kDa (m/z 34747.5230) serine protease (lunathrombase) showing fibrin(ogen)olytic activity and devoid of N- and O- linked oligosaccharides was purified from an extract of aqueous leaves from L. indica. The LC-MS/MS analysis, de novo sequencing, secondary structure, and amino acid composition determination suggested the enzyme's novel characteristic...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29670004/analogs-of-the-scorpion-venom-peptide-stigmurin-structural-assessment-toxicity-and-increased-antimicrobial-activity
#9
Adriana M S Parente, Alessandra Daniele-Silva, Allanny A Furtado, Menilla A Melo, Ariane F Lacerda, Moacir Queiroz, Cláudia Moreno, Elizabeth Santos, Hugo A O Rocha, Euzébio G Barbosa, Eneas Carvalho, Arnobio A Silva-Júnior, Marcelo S Silva, Matheus de F Fernandes-Pedrosa
Scorpion venom is a rich source of biologically active components and various peptides with high-potential therapeutic use that have been characterized for their antimicrobial and antiproliferative activities. Stigmurin is a peptide identified from the Tityus stigmurus venom gland with high antibacterial and antiproliferative activities and low toxicity. Amino acid substitutions in peptides without a disulfide bridge sequence have been made with the aim of reducing their toxicity and increasing their biological activities...
April 18, 2018: Toxins
https://www.readbyqxmd.com/read/29669399/the-impact-of-systemic-lupus-erythematosus-on-the-clinical-phenotype-of-antiphospholipid-antibody-positive-patients-results-from-antiphospholipid-syndrome-alliance-for-clinical-trials-and-international-networking-aps-action-clinical-database-and-repository
#10
Ozan Unlu, Doruk Erkan, Medha Barbhaiya, Danieli Andrade, Iana Nascimento, Renata Rosa, Alessandra Banzato, Vittorio Pengo, Amaia Ugarte, Maria Gerosa, Lanlan Ji, Maria Efthymiou, D Ware Branch, Guilherme Raires de Jesus, Angela Tincani, H Michael Belmont, Paul R Fortin, Michelle Petri, Esther Rodriguez, Guillermo J Pons-Estel, Jason S Knight, Tatsuya Atsumi, Rohan Willis, Stephane Zuily, Maria G Tektonidou
OBJECTIVE: Although systemic lupus erythematosus (SLE) is the most common autoimmune disease associated with antiphospholipid antibodies (aPL), limited data exist on the impact of SLE on the clinical phenotype of aPL-positive patients. The primary objective was to compare the clinical, laboratory, and treatment characteristics of aPL-positive patients with or without SLE. METHODS: A secure web-based data capture system stores patient demographics, and aPL-related clinical and laboratory characteristics...
April 18, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29668553/glucose-homeostasis-markers-in-beta-thalassemia
#11
Sunil Gomber, Anjali Bagaria, Sri V Madhu, Pooja Dewan
BACKGROUND: Glycosylated hemoglobin (HbA1c) has been a well-recognized marker of glucose homeostasis among thalassemics. Recently some studies have proposed the role of fructosamine as a better marker as compared with HbA1c. Hence, the study was carried out to find out which marker holds promise among Indian beta-thalassemic children. METHODS: In this case-control study, 60 diagnosed cases of beta-thalassemia major and equal number of normal controls who were ≥8 years of age were enrolled...
April 17, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29668551/fetal-onset-congenital-dyserythropoietic-anemia-type-1-due-to-a-novel-mutation-with-severe-iron-overload-and-severe-cholestatic-liver-disease
#12
Hui-Lin Chin, Le Ye Lee, Pei Lin Koh
We report a rare case of severe congenital dyserythropoietic anemia type 1 with fetal onset. Our patient presented with fetal hydrops from 19 weeks of gestation, requiring multiple intrauterine transfusions. At birth, she had severe hemolytic anemia with severe jaundice, and was subsequently transfusion dependent. She eventually developed severe iron overload and fulminant liver failure before her demise at 5 months of age. Genetic testing revealed a novel mutation in CDAN1.
April 17, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29668537/cerebral-sinus-venous-thrombosis-and-prothrombotic-risk-factors-in-children-a-single-center-experience-from-turkey
#13
Alper Ozcan, Mehmet Canpolat, Selim Doganay, Ekrem Unal, Musa Karakukcu, Mehmet A Ozdemir, Turkan Patiroglu
BACKGROUND: Cerebral sinus venous thrombosis (CSVT) is a rare cerebrovascular disease that may be life-threatening, especially in children. OBJECTIVE: The purpose of this study was to assess the clinical presentation, radiologic imaging, underlying conditions, treatment, and outcomes of children with CSVT. PATIENTS AND METHODS: In total, 23 consecutive children aged between 1 month to 18 years with CSVT, who were followed-up in Erciyes University Children's Hospital, were retrospectively enrolled in the study from January 2000 to December 2016...
April 17, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29668291/reducing-the-cytotoxicity-of-lipid-nanoparticles-associated-with-a-fusogenic-cationic-lipid-in-a-natural-killer-cell-line-by-introducing-a-polycation-based-sirna-core
#14
Takashi Nakamura, Koharu Yamada, Yuki Fujiwara, Yusuke Sato, Hideyoshi Harashima
Introducing siRNA into human immune cells by an artificial delivery system continues to be a challenging issue. We previously developed a multifunctional envelope-type nanodevice (MEND) containing YSK12-C4, a fusogenic-cationic lipid, (YSK12-MEND) and succeeded in the efficient delivery of siRNA into human immune cell lines. Significant cytotoxicity, however, was observed at siRNA doses needed for gene silencing in NK-92 cells. NK-92 cells, a unique natural killer (NK) cell line, would be applicable for use in clinical NK therapy...
April 18, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29665852/a-novel-method-for-demonstrating-cold-agglutinin-disease-a-case-report
#15
Thomas A Vo, Zack Oakey, Yasir A Khan, Donald S Minckler
BACKGROUND: Cold agglutinin disease is a rare disorder characterized by an autoimmune hemolytic anemia occurring at low temperatures. Physical examination findings, often limited to acrocyanosis, are combined with a thermal amplitude test to help establish the diagnosis. Thermal amplitude testing determines the highest temperature at which the cold agglutination will occur and is an important parameter in diagnosing cold agglutinin disease. CASE PRESENTATION: Here we describe a 57-year-old white man of German and Nicaraguan descent with known chronic cold agglutinin disease who presented to our ophthalmology clinic for evaluation of a cataract...
April 18, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29664112/efficacy-of-d-red-blood-cell-transfusion-and-rituximab-therapy-in-autoimmune-hemolytic-anemia-with-anti-d-and-panreactive-autoantibodies-arising-after-hematopoietic-stem-cell-transplant
#16
Keiji Minakawa, Hitoshi Ohto, Hiroyasu Yasuda, Shunichi Saito, Kinuyo Kawabata, Kazuei Ogawa, Kenneth E Nollet, Kazuhiko Ikeda
BACKGROUND: Autoimmune hemolytic anemia (AIHA) is caused by autoantibodies to red blood cells (RBCs), which can be panreactive and/or specific to Rh/other blood group antigens. We report a severe case of AIHA after bone marrow transplantation (BMT) due to autoanti-D triggered by reactivation of Epstein-Barr virus (EBV) infection. A combined strategy of D- RBC transfusion and administration of anti-CD20 monoclonal antibody (MoAb) resolved the hemolysis. CASE REPORT: A 33-year-old male underwent allogeneic BMT from an ABO-identical and HLA-matched unrelated male donor...
April 17, 2018: Transfusion
https://www.readbyqxmd.com/read/29663181/effects-of-dietary-organic-inorganic-and-nanoparticulate-selenium-sources-on-growth-hemato-immunological-and-serum-biochemical-parameters-of-common-carp-cyprinus-carpio
#17
Sadegh Saffari, Saeed Keyvanshokooh, Mohammad Zakeri, Seyed Ali Johari, Hossein Pasha-Zanoosi, Mansour Torfi Mozanzadeh
An 8-week feeding trial was conducted to compare the effects of supplementing (0.7 mg kg-1 ) different dietary selenium (Se) sources including organic [selenomethionine (SeMet)], inorganic [sodium selenite (Na2 SeO3 )], and nanoparticulate Se (nano-Se) on physiological responses of common carp, Cyprinus carpio juveniles (9.7 ± 0.1 g). Basal diet without Se supplementation used as control. Fish fed nano-Se supplemented diet had the highest weight gain (97.2 ± 10.8%) and feed efficiency ratio (42...
April 16, 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29662860/splenic-myeloid-metaplasia-in-warm-autoimmune-hemolytic-anemia-waiha-a-retrospective-study
#18
Víctor Manuel Anguiano-Álvarez, Alonso Hernández-Company, Nashla Hamdan-Pérez, Daniel Montante-M, Diego A Zúñiga-Tamayo, Sergio Rodríguez-Rodríguez, Alan Pomerantz, Elena J Tuna-Aguilar
Background: Splenic myeloid metaplasia (SMM) is a kind of extramedullary hematopoiesis, whereas its clinical significance in wAIHA remains unclear. The aim of this study is evaluating the frequency and clinical characteristics of SMM, compared with splenic-congestion (SC). Methods: We included patients with wAIHA treated in a Mexican tertiary hospital between January 1992 and December 2015. All patients received steroids as first-line treatment and splenectomy as second-line treatment...
March 2018: Blood Research
https://www.readbyqxmd.com/read/29662857/cryohemolysis-erythrocyte-osmotic-fragility-and-supplementary-hematimetric-indices-in-the-diagnosis-of-hereditary-spherocytosis
#19
Ledesma Achem Miryam Emilse, Haro Cecilia, Terán Magdalena María, Mónaco María Eugenia, Issé Blanca Alicia, Sandra Stella Lazarte
Background: Hereditary spherocytosis (HS) is a chronic hemolytic anemia characterized by microspherocytes in the peripheral blood and increased erythrocyte osmotic fragility (EOF). This study evaluated the cryohemolysis test (CHT); initial hemolysis (IH); immediate and incubated hemolysis percentage in 5.5 g/L NaCl (H5.5); mean corpuscular hemoglobin concentration (MCHC); red blood cell distribution width (RDW); and Hb/MCHC, Hb/RDW, and MCHC/RDW ratios for the diagnosis of HS. Methods: Data from 13 patients with HS were evaluated at the Instituto de Bioquímica Aplicada and compared with data from 14 unaffected individuals and 11 patients with anemia due to another etiology...
March 2018: Blood Research
https://www.readbyqxmd.com/read/29661593/-diagnostic-workup-in-front-of-an-atypical-non-hemolytic-anemia
#20
J Y Colin, G Vignon, P Mottaz, J Labrousse, F Carrere, P F Augereau, P Aucher, F Lellouche
The most potential causes of "non hemolytic" anemias are iron, folate or vitamin B12 deficiencies, severe renal impairment, endocrine diseases, inflammation and medullary disorders. In a non-exceptionnal way no cause is found, sometimes because of a wrong interpretation of analysis results and sometimes because of a little known etiology. The goal of this review is to point out analytical difficulties and to remember some rarer etiologies.
April 13, 2018: La Revue de Médecine Interne
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