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IL22

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https://www.readbyqxmd.com/read/28296821/protease-activated-receptor-1-plays-a-proinflammatory-role-in-colitis-by-promoting-th17-related-immunity
#1
Muhammad A Saeed, Garrett Z Ng, Jan Däbritz, Josef Wagner, Louise Judd, Jia-Xi Han, Poshmaal Dhar, Carl D Kirkwood, Philip Sutton
BACKGROUND: Proteolytic cleavage of protease-activated receptor 1 (PAR1) can result in potent downstream regulatory effects on inflammation. Although PAR1 is expressed throughout the gastrointestinal tract and activating proteases are increased in inflammatory bowel disease, the effect of PAR1 activation on colitis remains poorly understood, and has not previously been studied in pediatric disease. METHODS: Expression of PAR1 and inflammatory cytokines in colonic biopsies from pediatric patients with Crohn's disease exhibiting active moderate to severe colitis was measured by quantitative PCR...
April 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28286877/il-22-controls-iron-dependent-nutritional-immunity-against-systemic-bacterial-infections
#2
Kei Sakamoto, Yun-Gi Kim, Hideki Hara, Nobuhiko Kamada, Gustavo Caballero-Flores, Emanuela Tolosano, Miguel P Soares, José L Puente, Naohiro Inohara, Gabriel Núñez
Host immunity limits iron availability to pathogenic bacteria, but whether immunity limits pathogenic bacteria from accessing host heme, the major source of iron in the body, remains unclear. Using Citrobacter rodentium, a mouse enteric pathogen and Escherichia coli, a major cause of sepsis in humans as models, we find that interleukin-22, a cytokine best known for its ability to promote epithelial barrier function, also suppresses the systemic growth of bacteria by limiting iron availability to the pathogen...
February 2017: Science Immunology
https://www.readbyqxmd.com/read/28177259/radiation-induced-dermatitis-is-mediated-by-il17-expressing-%C3%AE-%C3%AE-t-cells
#3
Wupeng Liao, Tom K Hei, Simon K Cheng
Radiation dermatitis is a serious cutaneous injury caused by radiation therapy or upon accidental nuclear exposure. However, the pathogenic immune mechanisms underlying this injury are still poorly understood. We seek to discover how the dysregulated immune response after irradiation orchestrates skin inflammation. The skin on the left flank of C57BL/6J wild-type and C57BL/6J Tcrd(-/-) mice, which are deficit in γδ T cells, was exposed to a single X-ray dose of 25 Gy, and the right-flank skin was used as a sham-irradiated control...
February 8, 2017: Radiation Research
https://www.readbyqxmd.com/read/28172748/p356-treatment-with-anakinra-induces-t-cell-production-of-il22-and-gi-mucosal-healing-in-an-il-10ra-mutation-patient
#4
J Li, D Shouval, A Doty, S Snapper, S Glover
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28139719/a-functional-il22-polymorphism-rs2227473-is-associated-with-predisposition-to-childhood-cerebral-malaria
#5
Sandrine Marquet, Ianina Conte, Belco Poudiougou, Laurent Argiro, Hélia Dessein, Charlène Couturier, Florence Burté, Aboubacar A Oumar, Biobele J Brown, Abdoualye Traore, Nathaniel K Afolabi, Abdoulaye Barry, Samuel Omokhodion, Wuraola A Shokunbi, Olugbemiro Sodeinde, Ogobara Doumbo, Delmiro Fernandez-Reyes, Alain J Dessein
Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection. This encephalopathy is characterized by coma and is thought to result from mechanical microvessel obstruction and an excessive activation of immune cells leading to pathological inflammation and blood-brain barrier alterations. IL-22 contributes to both chronic inflammatory and infectious diseases, and may have protective or pathogenic effects, depending on the tissue and disease state. We evaluated whether polymorphisms (n = 46) of IL22 and IL22RA2 were associated with CM in children from Nigeria and Mali...
January 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28115058/ccr6-is-dispensable-for-the-development-of-skin-lesions-induced-by-imiquimod-despite-its-effect-on-epidermal-homing-of-il-22-producing-cells
#6
Perrine M Cochez, Camille Michiels, Emilie Hendrickx, Nicolas Dauguet, Guy Warnier, Jean-Christophe Renauld, Laure Dumoutier
Expression of the chemokine receptor Ccr6 is shared by most IL-22 producing cells and Ccr6-deficient mice showed decreased IL-22 production and skin inflammation upon IL-23 intradermal injections. To determine whether this observation might be extended to another psoriasis model, we applied imiquimod on Ccr6-deficient mice. Whereas epidermal IL-22 production was decreased because of a deficient recruitment of γδ T cells in these mice, they were not protected against psoriatic lesions. When primary epidermis or dermis tissue culture cells from non-treated mice were stimulated ex vivo with IL-1α/IL-2/IL-23, we observed that Ccr6 is crucial for Il22 expression from epidermal but not dermal cultures...
January 20, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27876571/fusobacterium-nucleatum-increases-proliferation-of-colorectal-cancer-cells-and-tumor-development-in-mice-by-activating-toll-like-receptor-4-signaling-to-nuclear-factor-%C3%AE%C2%BA-up-regulating-expression-of-microrna-21
#7
Yongzhi Yang, Wenhao Weng, Junjie Peng, Leiming Hong, Lei Yang, Yuji Toiyama, Renyuan Gao, Minfeng Liu, Mingming Yin, Cheng Pan, Hao Li, Bomin Guo, Qingchao Zhu, Qing Wei, Mary-Pat Moyer, Ping Wang, Sanjun Cai, Ajay Goel, Huanlong Qin, Yanlei Ma
BACKGROUND & AIMS: Nearly 20% of the global cancer burden can be linked to infectious agents. Fusobacterium nucleatum promotes tumor formation by epithelial cells via unclear mechanisms. We aimed to identify microRNAs (miRNAs) induced by F nucleatum and evaluate their ability to promote colorectal carcinogenesis in mice. METHODS: Colorectal cancer (CRC) cell lines were incubated with F nucleatum or control reagents and analyzed in proliferation and would healing assays...
November 19, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27774581/a-preliminary-study-of-new-single-polymorphisms-in-the-t-helper-type-17-pathway-for-psoriasis-in-the-korean-population
#8
S Y Kim, M S Hur, B G Choi, M J Kim, Y W Lee, Y B Choe, K J Ahn
Psoriasis is a polygenic and multi-factorial disease showing ethnic differences in terms of its severity and frequency. Therapies targeting interleukin (IL)-17A, IL-17 receptor (IL-17R) and Janus kinases (JAKs) are in clinical development for the treatment of psoriasis, and their success suggests the essential role of these molecules in psoriasis. To investigate the genetic susceptibility in T helper type 17 (Th17) cell signal transduction pathways for promoting psoriasis, we performed candidate gene and linkage disequilibrium analysis...
February 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27769811/aryl-hydrocarbon-receptor-ligands-in-cigarette-smoke-induce-production-of-interleukin-22-to-promote-pancreatic-fibrosis-in-models-of-chronic-pancreatitis
#9
Jing Xue, Qinglan Zhao, Vishal Sharma, Linh P Nguyen, Yvonne N Lee, Kim L Pham, Mouad Edderkaoui, Stephen J Pandol, Walter Park, Aida Habtezion
BACKGROUND & AIMS: Cigarette smoke has been identified as an independent risk factor for chronic pancreatitis (CP). Little is known about the mechanisms by which smoking promotes development of CP. We assessed the effects of aryl hydrocarbon receptor (AhR) ligands found in cigarette smoke on immune cell activation in humans and pancreatic fibrosis in animal models of CP. METHODS: We obtained serum samples from patients with CP treated at Stanford University hospital and healthy individuals (controls) and isolated CD4(+) T cells...
December 2016: Gastroenterology
https://www.readbyqxmd.com/read/27543072/il-22-derived-from-%C3%AE-%C3%AE-t-cells-restricts-staphylococcus-aureus-infection-of-mechanically-injured-skin
#10
Nidhi Malhotra, Juhan Yoon, Juan Manuel Leyva-Castillo, Claire Galand, Nathan Archer, Lloyd S Miller, Raif S Geha
BACKGROUND: Staphylococcus aureus is an opportunistic pathogen that colonizes the skin of patients with atopic dermatitis (AD) and aggravates their disease. Neutrophils and the cytokines IL-17A and IL-17F, which drive the expression of the neutrophil-attracting chemokines, are important for the clearance of S aureus infection. The cytokine IL-22 is often coproduced by IL-17-secreting cells. The levels of IL-22 are elevated in AD skin lesions. OBJECTIVE: We sought to determine the role of IL-22 in the clearance of S aureus infection of mouse skin subjected to tape stripping, a surrogate for scratching, a cardinal feature of AD...
October 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27534553/transcription-factor-hif-1%C3%AE-controls-expression-of-the-cytokine-il-22-in-cd4-t-cells
#11
Scott A Budda, Alanson Girton, Jacob G Henderson, Lauren A Zenewicz
IL-22 is expressed by activated lymphocytes and is important in modulation of tissue responses during inflammation. The cytokine induces proliferative and antiapoptotic pathways in epithelial cells allowing enhanced cell survival. This can have positive effects, such as in the maintenance of epithelial barriers in the gastrointestinal tract, but also negative effects, such as contributing to colorectal tumorigenesis. Because IL-22 can be dual-natured, we hypothesized that its biological activity should be tightly regulated to limit IL-22 expression to the sites of inflammation...
October 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27514477/acetylcholine-producing-t-cells-in-the-intestine-affect-antimicrobial-peptide-expression-and-microbial-diversity
#12
Shobhit Dhawan, Giada De Palma, Rose A Willemze, Francisca Hilbers, Caroline Verseijden, Misha Luyer, Sabine Nuding, Jan Wehkamp, Yuri Souwer, Esther C de Jong, Jurgen Seppen, Rene Mjgj van den Wijngaard, Sven Wehner, Elena F Verdu, Premysl Bercik, Wouter J de Jonge
The cholinergic anti-inflammatory pathway reduces systemic TNF via acetylcholine producing memory T-cells in the spleen. These choline acetyltransferase (ChAT) expressing T-cells are also found in the intestine, where their function is unclear. We aimed to characterize these cells in mouse and human intestine and delineate their function. We made use of the ChAT-eGFP reporter mice. CD4Cre mice were crossed to ChATfl/fl mice to achieve specific deletion of ChAT in CD4+ T-cells. We observed that the majority of ChAT expressing T-cells in the human and mouse intestine have characteristics of Th17 cells, and co-express IL17A, IL22 and RORC...
August 11, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27456484/critical-role-of-il-22-il22-ra1-signaling-in-pneumococcal-pneumonia
#13
Giraldina Trevejo-Nunez, Waleed Elsegeiny, Parker Conboy, Kong Chen, Jay K Kolls
IL-22-IL-22R signaling plays a crucial role in regulating host defenses against extracellular pathogens, particularly in the intestine, through the induction of antimicrobial peptides and chemotactic genes. However, the role of IL-22-IL-22R is understudied in Streptococcus pneumoniae lung infection, a prevalent pathogen of pneumonia. This paper presents the findings of IL-22 signaling during a murine model of pneumococcal pneumonia and improvement of bacterial burden upon IL-22 administration. IL-22 was rapidly induced in the lung during pneumococcal infection in wild-type mice, and Il22(-/-) mice had higher pneumococcal burdens compared with controls...
September 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27409807/glial-cell-derived-neuroregulators-control-type-3-innate-lymphoid-cells-and-gut-defence
#14
Sales Ibiza, Bethania García-Cassani, Hélder Ribeiro, Tânia Carvalho, Luís Almeida, Rute Marques, Ana M Misic, Casey Bartow-McKenney, Denise M Larson, William J Pavan, Gérard Eberl, Elizabeth A Grice, Henrique Veiga-Fernandes
Group 3 innate lymphoid cells (ILC3) are major regulators of inflammation and infection at mucosal barriers. ILC3 development is thought to be programmed, but how ILC3 perceive, integrate and respond to local environmental signals remains unclear. Here we show that ILC3 in mice sense their environment and control gut defence as part of a glial–ILC3–epithelial cell unit orchestrated by neurotrophic factors. We found that enteric ILC3 express the neuroregulatory receptor RET. ILC3-autonomous Ret ablation led to decreased innate interleukin-22 (IL-22), impaired epithelial reactivity, dysbiosis and increased susceptibility to bowel inflammation and infection...
July 21, 2016: Nature
https://www.readbyqxmd.com/read/27381887/staphylococcus-aureus-exploits-epidermal-barrier-defects-in-atopic-dermatitis-to-trigger-cytokine-expression
#15
Teruaki Nakatsuji, Tiffany H Chen, Aimee M Two, Kimberly A Chun, Saisindhu Narala, Raif S Geha, Tissa R Hata, Richard L Gallo
Patients with atopic dermatitis (AD) have an abnormal skin barrier and are frequently colonized by S. aureus. In this study we investigated if S. aureus penetrates the epidermal barrier of subjects with AD and sought to understand the mechanism and functional significance of this entry. S. aureus was observed to be more abundant in the dermis of lesional skin from AD patients. Bacterial entry past the epidermis was observed in cultured human skin equivalents and in mice but was found to be increased in the skin of cathelicidin knockout and ovalbumin-sensitized filaggrin mutant mice...
November 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27342734/early-activation-of-th2-th22-inflammatory-and-pruritogenic-pathways-in-acute-canine-atopic-dermatitis-skin-lesions
#16
Thierry Olivry, David Mayhew, Judy S Paps, Keith E Linder, Carlos Peredo, Deepak Rajpal, Hans Hofland, Javier Cote-Sierra
Determining inflammation and itch pathway activation in patients with atopic dermatitis (AD) is fraught with the inability to precisely assess the age of skin lesions, thus affecting the analysis of time-dependent mediators. To characterize inflammatory events occurring during early experimental acute AD lesions, biopsy samples were collected 6, 24, and 48 hours after epicutaneous application of Dermatophagoides farinae house dust mites to sensitized atopic dogs. The skin transcriptome was assessed using a dog-specific microarray and quantitative PCR...
October 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27311945/il-22-dampens-the-t-cell-response-in-experimental-malaria
#17
Julie Sellau, Catherine Fuentes Alvarado, Stefan Hoenow, Maria Sophie Mackroth, Dörte Kleinschmidt, Samuel Huber, Thomas Jacobs
A tight regulation between the pro- and anti-inflammatory immune responses during plasmodial infection is of crucial importance, since a disruption leads to severe malaria pathology. IL-22 is a member of the IL-10 cytokine family, which is known to be highly important in immune regulation. We could detect high plasma levels of IL-22 in Plasmodium falciparum malaria as well as in Plasmodium berghei ANKA (PbA)-infected C57BL/6J mice. The deficiency of IL-22 in mice during PbA infection led to an earlier occurrence of cerebral malaria but is associated with a lower parasitemia compared to wt mice...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27267361/kinetics-of-the-west-nile-virus-induced-transcripts-of-selected-cytokines-and-toll-like-receptors-in-equine-peripheral-blood-mononuclear-cells
#18
Muhammad Jasim Uddin, Willy W Suen, Angela Bosco-Lauth, Airn-Elizabeth Hartwig, Roy A Hall, Richard A Bowen, Helle Bielefeldt-Ohmann
West Nile virus (WNV) is one of the most common causes of epidemic viral encephalitis in horses worldwide. Peripheral blood mononuclear cells (PBMCs) are amongst the first to encounter the virus following a mosquito bite. This study aimed to elucidate the transcription kinetics of cytokine, Toll-like receptor (TLRs) and TLRs-associated genes following WNV challenge of equine PBMCs. PBMCs were challenged with an Australian strain of WNV (WNVNSW2011) and transcriptomes were quantified at 2, 6, 12 and 24 h post-infection (pi) using qRT-PCR...
2016: Veterinary Research
https://www.readbyqxmd.com/read/27245408/helicobacter-saguini-a-novel-helicobacter-isolated-from-cotton-top-tamarins-with-ulcerative-colitis-has-proinflammatory-properties-and-induces-typhlocolitis-and-dysplasia-in-gnotobiotic-il-10-mice
#19
Z Shen, A Mannion, M T Whary, S Muthupalani, A Sheh, Y Feng, G Gong, P Vandamme, H R Holcombe, B J Paster, J G Fox
A urease-negative, fusiform, novel bacterium named Helicobacter saguini was isolated from the intestines and feces of cotton-top tamarins (CTTs) with chronic colitis. Helicobacter sp. was detected in 69% of feces or intestinal samples from 116 CTTs. The draft genome sequence, obtained by Illumina MiSeq sequencing, for H. saguini isolate MIT 97-6194-5, consisting of ∼2.9 Mb with a G+C content of 35% and 2,704 genes, was annotated using the NCBI Prokaryotic Genomes Automatic Annotation Pipeline. H. saguini contains homologous genes of known virulence factors found in other enterohepatic helicobacter species (EHS) and H...
August 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27217583/pulmonary-th17-antifungal-immunity-is-regulated-by-the-gut-microbiome
#20
Jeremy P McAleer, Nikki L H Nguyen, Kong Chen, Pawan Kumar, David M Ricks, Matthew Binnie, Rachel A Armentrout, Derek A Pociask, Aaron Hein, Amy Yu, Amit Vikram, Kyle Bibby, Yoshinori Umesaki, Amariliz Rivera, Dean Sheppard, Wenjun Ouyang, Lora V Hooper, Jay K Kolls
Commensal microbiota are critical for the development of local immune responses. In this article, we show that gut microbiota can regulate CD4 T cell polarization during pulmonary fungal infections. Vancomycin drinking water significantly decreased lung Th17 cell numbers during acute infection, demonstrating that Gram-positive commensals contribute to systemic inflammation. We next tested a role for RegIIIγ, an IL-22-inducible antimicrobial protein with specificity for Gram-positive bacteria. Following infection, increased accumulation of Th17 cells in the lungs of RegIIIγ(-/-) and Il22(-/-) mice was associated with intestinal segmented filamentous bacteria (SFB) colonization...
July 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
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