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https://www.readbyqxmd.com/read/28643464/adiponectin-isoform-patterns-in-ethnic-specific-adipoq-mutation-carriers-the-iras-family-study
#1
Keri L Tabb, Chuan Gao, Pamela J Hicks, Gregory A Hawkins, Jerome I Rotter, Yii-Der Ida Chen, Xiuqing Guo, Jill M Norris, Carlos Lorenzo, Barry I Freedman, Donald W Bowden, Nicholette D Palmer
OBJECTIVE: Adiponectin is found in human serum in three groups of multimers (high molecular weight [HMW], medium molecular weight [MMW], and low molecular weight [LMW]). Two ethnic-specific variants in ADIPOQ, G45R (Hispanic-Americans) and R55C (African-Americans), were previously reported. Although carriers of both variants had mean adiponectin levels ≤ 20% of those of noncarriers, they were not clinically different from noncarriers. To compare carriers of both variants and noncarriers, relative quantification of adiponectin isoforms to total adiponectin was performed on serum samples...
June 23, 2017: Obesity
https://www.readbyqxmd.com/read/28642064/the-genetic-basis-of-deafness-in-populations-of-african-descent
#2
REVIEW
Jason R Rudman, Rosemary I Kabahuma, Sara E Bressler, Yong Feng, Susan H Blanton, Denise Yan, Xue-Zhong Liu
Hearing loss is the most common sensorineural disorder worldwide and is associated with more than 1000 mutations in more than 90 genes. While mutations in genes such as GJB2 (gap-junction protein β 2) and GJB6 (gap-junction protein β 6) are highly prevalent in Caucasian, Asian, and Middle Eastern populations, they are rare in both native African populations and those of African descent. The objective of this paper is to review the current knowledge regarding the epidemiology and genetics of hearing loss in African populations with a focus on native sub-Saharan African populations...
May 6, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28639281/resolving-relationships-between-several-neolithic-and-mesolithic-populations-in-northern-eurasia-using-geometric-morphometrics
#3
Ekaterina Stansfield Bulygina, Anna Rasskasova, Natalia Berezina, Andrei D Soficaru
OBJECTIVES: Remains from several Eastern European and Siberian Mesolithic and Neolithic sites are analysed to clarify their biological relationships. We assume that groups' geographical distances correlate with genetic and, therefore, morphological distances between them. MATERIALS AND METHODS: Material includes complete male crania from several Mesolithic and Neolithic burial sites across Northern Eurasia and from several modern populations. Geometric morphometrics and multivariate statistical techniques are applied to explore morphological trends, group distances, and correlations with their geographical position, climate, and the time of origin...
June 22, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28639238/multiple-sclerosis-in-latin-americans-genetic-aspects
#4
REVIEW
Victor M Rivera
Latin Americans (LA) are a heterogeneous, multiethnic group of individuals who inhabit the continental countries in Latin America (LATAM), Caribbean islands and constitute the largest ethnic minority in the USA. Commonly used terminology and ethno racial classifications to define these groups may not be accurate. Risk for multiple sclerosis (MS) among LA is generally low to medium but frequencies are increasing in the American hemisphere. Genome-Wide Association Studies (GWAS) in LA show diverse variants and genetic proportions among Mestizos, the most representative ethnic population, who themselves are the product of centuries of interracial mixing between Native Americans (or Amerindians), White Caucasian Europeans, and Black Africans...
August 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28638342/warfarin-anticoagulation-therapy-in-caribbean-hispanics-of-puerto-rico-a-candidate-gene-association-study
#5
Karla Claudio-Campos, Aurora Labastida, Alga Ramos, Andrea Gaedigk, Jessicca Renta-Torres, Dariana Padilla, Giselle Rivera-Miranda, Stuart A Scott, Gualberto Ruaño, Carmen L Cadilla, Jorge Duconge-Soler
Existing algorithms account for ~50% of observed variance in warfarin dose requirements after including common polymorphisms. However, they do not perform as well in populations other than Caucasians, in part because some ethno-specific genetic variants are overlooked. The objective of the present study was to identify genetic polymorphisms that can explain variability in warfarin dose requirements among Caribbean Hispanics of Puerto Rico. Next-Generation Sequencing of candidate genes CYP2C9 and VKORC1 and genotyping by DMET® Plus Assay of cardiovascular patients were performed...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28636089/geographic-substructure-in-craniometric-estimates-of-admixture-for-contemporary-american-populations
#6
Bridget F B Algee-Hewitt
OBJECTIVES: This study investigates heterogeneity in craniometrically-derived estimates of admixture in order to reveal population substructure in a sample of Black, White, Hispanic, and Native American individuals from the FDB. It reports evidence of spatial trends in population-specific patterns of admixture and contextualizes its results in terms of demographic diversity in the United States. MATERIALS AND METHODS: The FDB was sampled to capture the population variation within forensic casework, skeletal collections, and the U...
June 21, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28624126/racial-and-ethnic-disparities-in-the-u-s-breastfeeding-and-implications-for-maternal-and-child-health-outcomes
#7
Adetola Louis-Jacques, Tara F Deubel, Melina Taylor, Alison M Stuebe
Marked racial and ethnic disparities exist in infant feeding in the United States. Based on a review of recent literature, this article examines current discrepancies between the 2020 Healthy People breastfeeding goals and current breastfeeding rates among women from different ethnic groups in the United States. We discuss maternal and child health outcomes associated with breastfeeding, and we review potential causes of racial and ethnic disparities in breastfeeding outcomes in the United States, especially among non-Hispanic Black, American Indian/Alaska Native, and Hispanic/Latina populations...
June 14, 2017: Seminars in Perinatology
https://www.readbyqxmd.com/read/28624027/racial-disparities-in-treatment-and-survival-of-hepatocellular-carcinoma-in-native-americans-and-hispanics
#8
Eyas Alkhalili, Alissa Greenbaum, Li Luo, Rodrigo Rodriguez, Oscar Estrada Munoz, Jacqueline O'Neill, Itzhak Nir, Katherine T Morris
BACKGROUND: We investigated if there were any differences in disease presentation and survival between the 3 major ethnicities in New Mexico; non-Hispanic whites (NHW), native Americans (NA), and Hispanics (H). METHODS: A retrospective analysis of patients with hepatocellular carcinoma treated at our institution between 2000 and 2014 was performed. Overall survival was analyzed using the Kaplan-Meier and Cox regression models. RESULTS: We identified 326 patients; 106 (32...
July 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28620950/the-risk-typology-of-healthcare-access-and-its-association-with-unmet-healthcare-needs-in-asian-americans
#9
Yuri Jang, Nan Sook Park, Hyunwoo Yoon, Ya-Ching Huang, Min-Kyoung Rhee, David A Chiriboga, Miyong T Kim
Using data from the 2015 Asian American Quality of Life Survey (N = 2,609), latent profile analysis was conducted on general (health insurance, usual place for care and income) and immigrant-specific (nativity, length of stay in the U.S., English proficiency and acculturation) risk factors of healthcare access. Latent profile analysis identified a three-cluster model (low-risk, moderate-risk and high-risk groups). Compared with the low-risk group, the odds of having an unmet healthcare need was 1.52 times greater in the moderate-risk group and 2...
June 15, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28618394/clinicopathological-characteristics-and-survival-outcomes-of-male-breast-cancer-according-to-race-a-seer-population-based-study
#10
He-Fen Sun, Yang Zhao, Shui-Ping Gao, Liang-Dong Li, Wen-Yan Fu, Hong-Lin Jiang, Meng-Ting Chen, Li-Peng Yang, Wei Jin
To investigate the clinicopathological characteristics and survival outcomes of breast cancer in the male population, 8,607 cases of patients were identified in the Surveillance, Epidemiology, and End Results (SEER) database, including white males (n = 7122), black males (n = 1111), and other males (American Indian/AK Native, Asian/Pacific Islander) (n = 374). Black male breast cancer patients were more likely to be in stages II-IV and have more advanced tumors. The rate of lymph node (LN) involvement at diagnosis was higher in black men than in whites and others...
May 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28618322/multiple-inflammatory-markers-and-15-year-incident-adl-disability-in-admixed-older-adults-the-bambui-epigen-study
#11
Maria Fernanda Lima-Costa, Juliana V M Mambrini, Karen C L Torres, Sérgio V Peixoto, Fabíola B Andrade, Cesar De Oliveira, Eduardo Tarazona-Santos, Andrea Teixeira-Carvalho, Olindo A Martins-Filho
BACKGROUND: The ability of inflammatory markers to predict disability in later life has received growing attention. However, the current evidence came predominantly from Caucasians and the role of genomic ancestry has not been investigated. OBJECTIVE: We investigated the prognostic value of multiple citokynes and chemokines for incident disability in admixed older Brazilians and whether genomic African and Native American ancestry affects the association. DESIGN: Population-based longitudinal study...
June 7, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28617079/particle-exposure-and-the-historical-loss-of-native-american-lives-to-infections
#12
Andrew J Ghio
No abstract text is available yet for this article.
June 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28616198/seed-dispersal-of-diospyros-virginiana-in-the-past-and-the-present-evidence-for-a-generalist-evolutionary-strategy
#13
Mimi Rebein, Charli N Davis, Helena Abad, Taylor Stone, Jillian Del Sol, Natalie Skinner, Matthew D Moran
Several North American trees are hypothesized to have lost their co-evolved seed disperser during the late-Pleistocene extinction and are therefore considered anachronistic. We tested this hypothesis for the American persimmon (Diospyros virginiana) by studying the effects of gut passage of proposed seed dispersers on seedling survival and growth, natural fruiting characteristics, and modern animal consumption patterns. We tested gut passage effects on persimmon seeds using three native living species, the raccoon (Procyon lotor), Virginia opossum (Didelphis virginiana), and coyote (Canis latrans), and two Pleistocene analogs; the Asian elephant (Elephas maximus) and alpaca (Vicugna pacos)...
June 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28608574/the-attitude-of-latin-american-immigrants-in-florida-usa-towards-deceased-organ-donation
#14
Antonio Ríos, Ana Isabel López-Navas, José Antonio García, Gregorio Garrido, Marco Antonio Ayala-García, María José Sebastián, Antonio Miguel Hernandez, Pablo Ramírez, Pascual Parrilla
INTRODUCTION: The Latin American (LA) population resident in the USA is a growing subgroup of the population. OBJECTIVE: To find out the structure of attitude towards organ donation in the LA population resident in Florida (USA). METHODS: A sample was taken of LA residents in Florida, randomised and stratified by nationality, age and sex (n=1524). Attitude was assessed using a validated questionnaire (PCID-DTO Rios), that was self-completed anonymously...
June 13, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28607453/specific-skeletal-muscle-sphingolipid-compounds-in-energy-expenditure-regulation-and-weight-gain-in-native-americans-of-southwestern-heritage
#15
S Heinitz, P Piaggi, K L Vinales, A Basolo, J Spranger, D Piomelli, J Krakoff, S R Jumpertz von
BACKGROUND/OBJECTIVES: In animal models, a role in the regulation of energy expenditure (EE) has been ascribed to sphingolipids, active components of cell membranes participating in cellular signaling. In humans, it is unknown whether sphingolipids play a role in the modulation of EE and, consequently, influence weight gain. The present study investigated the putative association of EE and weight gain with sphingolipid levels in human skeletal muscle, a component of fat-free mass (the strongest determinant of EE) in adipose tissue and in plasma...
June 13, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28605396/traffic-related-pollutants-exposure-and-health-effects-in-hispanic-children
#16
Garrett M Weaver, W James Gauderman
We examined traffic-related pollution (TRP) exposure and respiratory health effects in Hispanic white (HW) children, both compared to non-Hispanic white (NHW) children and by genetically-determined Native American (NA) ancestry. The sample included over 5,000 children from the Children's Health Study, followed from 1993 to 2014. HW children were 1.47 (95% CI: 1.24, 1.73) times more likely to live close ( < 500m) to a freeway and 1.54 (95% CI: 1.26, 1.87) times more likely to live close ( < 75m) to a major non-freeway road compared to NHW children...
June 9, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28599541/prosodic-exaggeration-within-infant-directed-speech-consequences-for-vowel-learnability
#17
Frans Adriaans, Daniel Swingley
Perceptual experiments with infants show that they adapt their perception of speech sounds toward the categories of the native language. How do infants learn these categories? For the most part, acoustic analyses of natural infant-directed speech have suggested that phonetic categories are not presented to learners as separable clusters of sounds in acoustic space. As a step toward explaining how infants begin to solve this problem, the current study proposes that the exaggerated prosody characteristic of infant-directed speech may highlight for infants certain speech-sound tokens that collectively form more readily identifiable categories...
May 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28598016/race-ethnicity-and-cardiovascular-events-among-patients-with-systemic-lupus-erythematosus
#18
Medha Barbhaiya, Candace H Feldman, Hongshu Guan, Jose A Gómez-Puerta, Michael A Fischer, Daniel H Solomon, Brendan Everett, Karen H Costenbader
OBJECTIVE: Systemic Lupus Erythematosus (SLE) is more prevalent with more severe outcomes among Blacks, Asians, and Hispanics than Whites. Cardiovascular disease (CVD) is the leading cause of death among SLE patients. We examined racial/ethnic variation in risk of CVD events among SLE patients. METHODS: Within Medicaid Analytic eXtract (2000-2010), we identified patients aged 18-65 with SLE (≥ 3 ICD-9 710.0 codes, ≥30 days apart) and ≥12 months of continuous enrollment...
June 9, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28590168/experimental-life-cycle-of-varestrongylus-eleguneniensis-nematoda-protostrongylidae-in-a-captive-reindeer-rangifer-tarandus-tarandus-and-a-muskox-ovibos-moschatus-moschatus
#19
Pratap Kafle, Josh Sullivan, Guilherme G Verocai, Susan J Kutz
The life-cycle of a recently described protostrongylid lungworm, Varestrongylus eleguneniensis, which infects caribou, muskoxen, and moose from Arctic and boreal regions of North America, was completed experimentally for the first time. A pilot study produced no patent infections when the muskox and reindeer were exposed to 51 and 30 infective third-stave larvae (L3) respectively, derived from a non-native intermediate host, Deroceras reticulatum. In the present study, a native North American native slug species, Deroceras leave was infected with the first-stage larvae (L1), isolated from the feces of wild muskoxen, to generate L3 which were administered to a captive reindeer calf ( 250 L3) and an adult captive muskox (380 L3)...
June 7, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28586255/disparities-in-assisted-reproductive-technology-utilization-by-race-and-ethnicity-united-states-2014-a-commentary
#20
Ada C Dieke, Yujia Zhang, Dmitry M Kissin, Wanda D Barfield, Sheree L Boulet
Disparities in infertility and access to infertility treatments, such as assisted reproductive technology (ART), by race/ethnicity, have been reported. However, identifying disparities in ART usage may have been hampered by missing race/ethnicity information in ART surveillance. We review infertility prevalence and treatment disparities, use recent data to examine ART use in the United States by race/ethnicity and residency in states with mandated insurance coverage for in vitro fertilization (IVF), and discuss approaches for reducing disparities...
June 2017: Journal of Women's Health
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