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Vahit Mutlu, Hayri Ogul
Carotid body tumors originate from paraganglionic tissue in the bifurcation of the common carotid artery. Magnetic resonance imaging is a frequently used diagnostic method in the preoperative diagnosis of these tumors and provides appropriate information for surgical planning. In this study, the authors emphasize magnetic resonance imaging and magnetic resonance angiography findings of the external carotid artery aneurysm associated with carotid body tumor. This highlights that the diagnosis of carotid artery aneurysms is essential to avoid accidental injury to the vessel during tumor surgery...
October 14, 2016: Journal of Craniofacial Surgery
Ayuko Sokabe, Masafumi Mizooka, Rinne Sakemi, Tomoki Kobayashi, Nobusuke Kishikawa, Kenichi Yokobayashi, Keishi Kanno, Susumu Tazuma
Jugular paraganlioma is a benign, slow-growing tumor originating from the paraganglion cells and it is associated with catecholamine secretion. Paragangliomas can secrete Interleukin-6 (IL-6) and present as a systemic inflammatory syndrome; these characteristics have not been previously associated with jugular paragangliomas. A 63-year-old man with a jugular tumor in the skull base was referred to our hospital for an evaluation of pyrexia, back pain, and acute inflammation. His serum IL-6 level was elevated on admission and it decreased after radiotherapy...
2016: Internal Medicine
O A M Adesiyun, P O Adeoye, C K P Ofoegbu, E A O Afolayan
Chemodectoma, a neuroendocrine tumour of the paraganglionic cells in the carotid body remains an uncommon tumour. We report the first case from University of Ilorin Teaching Hospital, Ilorin, Nigeria. Though with a red herring history of trauma induced swelling, clinical and radiologic features were characteristic of chemodectoma. Histologic features of the excised lesion are presented.
December 2015: African Journal of Medicine and Medical Sciences
José María González-Santos, María Elena Arnáiz-García, Ángel Muñoz-Herrera, Javier López-Rodríguez
A 60-year-old male patient who previously underwent carotid and jugular paraganglioma resections was referred because of a mediastinal recurrence at the root of the great vessels. Coronary angiography confirmed the circumflex artery of the left coronary artery as the feeding artery of the tumour. The patient underwent surgery due to the tumour's location and malignant potential. Upon mass resection, histopathological examination characterized the tumour as a secondary paraganglioma. Neuroendocrine tumours arising from chromaffin tissues at the extra-adrenal paraganglions of the autonomic nervous system are termed paragangliomas...
July 1, 2016: Interactive Cardiovascular and Thoracic Surgery
Sean Woolen, Joseph J Gemmete
Paragangliomas of the head and neck are rare vascular skull-base tumors derived from the paraganglionic system with an estimated incidence of 1:30,000 accounting for 3% of all paragangliomas. The most common paraganglioma locations of the head and neck in descending order are the carotid body, jugular, tympanic, and vagal paragangliomas. This article discusses the clinical characterics, normal anatamy, imaging findings and protocols, pathology, staging, and differential diagnosis for paragangliomas of the head and neck...
May 2016: Neuroimaging Clinics of North America
Jeffrey Tzu-Yu Wang, Allen Yu-Yu Wang, Sheila Cheng, Lavier Gomes, Melville Da Cruz
Paragangliomas are slow growing, hypervascular neuroendocrine tumors that develop in the extra-adrenal paraganglion tissues. Paraganglioma involving the vagus nerve ganglia is termed glomus vagale. The slow growth of head and neck paragangliomas especially in the absence of symptom may obviate the necessity for any active intervention, in which case, a "wait and scan" policy is implemented involving long-term clinical and radiologic follow-ups. We present a case of a 71-year-old female with an untreated left glomus vagale who underwent a conservative "wait and rescan" plan of management and the tumor was observed with 8 serial MRI scans over a period of 7...
2016: Case Reports in Otolaryngology
Michael G Moore, James L Netterville, William M Mendenhall, Brandon Isaacson, Brian Nussenbaum
OBJECTIVE: Head and neck paragangliomas are a group of slow-growing hypervascular tumors associated with the paraganglion system. The approach to evaluate and treat these lesions has evolved over the last 2 decades. While radical surgery had been the traditional approach, improvements in diagnostic imaging as well as radiation therapy techniques have led to an emphasis on observation and nonsurgical therapy in many patients. This article reviews the contemporary approach to the workup and management of head and neck paragangliomas...
April 2016: Otolaryngology—Head and Neck Surgery
Nicolasine D Niemeijer, Thomas G Papathomas, Esther Korpershoek, Ronald R de Krijger, Lindsey Oudijk, Hans Morreau, Jean-Pierre Bayley, Frederik J Hes, Jeroen C Jansen, Winand N M Dinjens, Eleonora P M Corssmit
CONTEXT: Mutations in genes encoding the subunits of succinate dehydrogenase (SDH) can lead to pheochromocytoma/paraganglioma formation. However, SDH mutations have also been linked to nonparaganglionic tumors. OBJECTIVE: The objective was to investigate which nonparaganglionic tumors belong to the SDH-associated tumor spectrum. DESIGN: This was a retrospective cohort study. SETTING: The setting was a tertiary referral center...
October 2015: Journal of Clinical Endocrinology and Metabolism
Bora E Baysal, Eamonn R Maher
Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine neoplasms that derive from small paraganglionic tissues which are located from skull base to the pelvic floor. Genetic predisposition plays an important role in development of PPGLs. Since the discovery of first mutations in the succinate dehydrogenase D (SDHD) gene, which encodes the smallest subunit of mitochondrial complex II (SDH), genetic studies have revealed a major role for mutations in SDH subunit genes, primarily in SDHB and SDHD, in predisposition to both familial and non-familial PPGLs...
August 2015: Endocrine-related Cancer
Alex D Sweeney, Matthew L Carlson, George B Wanna, Marc L Bennett
Glomus tympanicum (GT) tumors are benign arising from paraganglion cells of the tympanic plexus in the middle ear. Although surgical resection remains the best option for definitive treatment of these tumors, the diagnostic and management algorithms have evolved considerably with the introduction of high-resolution computed tomography, MRI, and genetic testing.
April 2015: Otolaryngologic Clinics of North America
Abdurrahim Colak, Munacettin Ceviz, Necip Becit, Aysenur Dostbil, Hikmet Kocak
Carotid body tumors arise from the embryonic neural crest. These tumors are mostly benign, and they rarely show character. Bifurcation of the carotid body cells originates from a common carotid paraganglion; a tumoral mass lateral to the carotid bifurcation is usually found in the neck. A pathologic feature of these tumors is that they have a tendency to wrap because they are not treated with the external and internal carotid arteries. In our clinic, we operated on a patient who had been diagnosed with carotid body tumor...
August 2012: Eurasian Journal of Medicine
Alfred King-Yin Lam
Paraganglioma normally occurs in sites that parallel the sympathetic and parasympathetic chain ganglions. Common locations of paraganglioma include tumours of paraganglionic system in head and neck region like carotid body paraganglioma and jugulotypmanic paraganglioma. There are also paragangliomas that occur outside the usual distribution of sympathetic and parasympathetic paraganglia. Pathological diagnosis of paraganglioma depends on the characteristic histological features and immnohistochemical detection of neuroendocrine marker(s)...
October 2014: Pathology
Kais Kasem, Alfred Lam
Extra-adrenal paragangliomas are uncommon tumors arising from neuroectodermal-derived paraganglion tissue. These tumors are usually located in the carotid body, the jugulotympanic body or the mediastinum. A limited number of primary pulmonary paragangliomas have been reported previously. We present a case of a 63-year-old lady with a 12-pack-year smoking history and shortness of breath. Radiological investigations revealed a single right middle lobe pulmonary mass with homogenous density and lobulated borders on CT scan...
October 2014: Pathology
Toshi Mishra, Naina A Goel, Atul H Goel
CONTEXT: Spinal paragangliomas are rare neuroendocrine tumors of the extra-adrenal paraganglionic system. AIMS: This study describes the clinicopathological features of eight cases of spinal paraganglioma and highlights the significance of important morphological features and immunohistochemistry in the diagnosis of paraganglioma at this unusual site. MATERIAL AND METHODS: All the cases of primary spinal paragangliomas diagnosed during the last six years (2008-2013) in the Department of Pathology at our hospital were reviewed...
January 2014: Journal of Craniovertebral Junction and Spine
Cr Baker, P Bhagwat, A Wan
We report on an original case of a 64 year old lady diagnosed with an extraadrenal mesenteric paraganglioma associated with an incidental histological finding of a gallbladder paraganglion. Paragangliomas are rare neuroendocrine, neural crest-derived tumours, found in diverse locations and display variable catecholamine secreting behaviour. Malignant potential can be difficult to predict on histology. We review the current literature on these multifarious tumours.
2012: Journal of Surgical Case Reports
Constancio Gonzalez, Silvia V Conde, Teresa Gallego-Martín, Elena Olea, Elvira Gonzalez-Obeso, Maria Ramirez, Sara Yubero, Maria T Agapito, Angela Gomez-Niñno, Ana Obeso, Ricardo Rigual, Asunción Rocher
When de Castro entered the carotid body (CB) field, the organ was considered to be a small autonomic ganglion, a gland, a glomus or glomerulus, or a paraganglion. In his 1928 paper, de Castro concluded: "In sum, the Glomus caroticum is innervated by centripetal fibers, whose trophic centers are located in the sensory ganglia of the glossopharyngeal, and not by centrifugal [efferent] or secretomotor fibers as is the case for glands; these are precisely the facts which lead to suppose that the Glomus caroticum is a sensory organ...
2014: Frontiers in Neuroanatomy
Kusum D Jashnani, Roshni D Patil, Dharmesh J Balsarkar
Paragangliomas are uncommon tumors arising in paraganglion tissue, which is well represented in the head and neck. A correct pre-operative cytological diagnosis helps in planning early and optimal surgery. Cytologic features in carotid body tumor and extra adrenal paragangliomas have been well described and documented. In addition to the acinar and discrete arrangement of cells, smears also showed a few large loose clusters of cells enveloped by thin vascular channels-the so-called zellballen pattern, a diagnostic feature on histopathology...
October 2013: Journal of Cytology
B J Wong, D E Roos, M F Borg
Glomus jugulare tumours (GJT) are one of a family of benign hypervascular neoplasms that arise from chief cells of the paraganglionic tissue from the dome of the jugular bulb. Historically, these tumours have primarily been managed surgically but radiation is an alternative treatment modality. The purpose of this retrospective review was to determine the patient survival, tumour control, clinical control rates and long term toxicity of GJT treated with radiation in South Australia. Between 1996 and 30 June 2012, 15 patients with GJT (16 tumours) were managed with radiotherapy...
March 2014: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Hideyuki Kano, L Dade Lunsford
Chordomas and chondrosarcomas are rare, slow-glowing, locally aggressive tumors with high recurrence rates. Stereotactic radiosurgery (SRS) is an important management option for patients with recurrent or residual chordomas and chondrosarcomas. Glomus jugulare tumor are rare highly vascularized tumors that arise from the paraganglionic structures of the glossopharyngeal and vagal nerves. Because of their highly vascular nature and surgically formidable anatomic location, curative resection often proves challenging...
October 2013: Neurosurgery Clinics of North America
Maaz A Ghouri, Elangovan Krishnan, Awinderpreet Singh, Tariq Zaman, Charles H Hallman
Nonfunctional paragangliomas are slow-growing, typically benign tumors that arise from the extra-adrenal paraganglion of the autonomic nervous system. They are identified and characterized with the use of computed tomography and other imaging methods; for definitive diagnosis, histopathologic evaluation is crucial. Surgical resection is the treatment of choice, and results of postoperative biochemical testing can reveal recurrence. Because of this lesion's familial association, genetic testing is suggested...
2013: Texas Heart Institute Journal
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