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https://www.readbyqxmd.com/read/29154107/aripiprazole-in-treatment-of-gilles-de-la-tourette-syndrome-new-therapeutic-option
#1
REVIEW
Piotr Janik, Natalia Szejko
Aripiprazole is a dopamine D2- and serotonin 5-hydroxytryptamine (5-HT)1A receptor partial agonist and 5-HT2A receptor antagonist primarily used for the treatment of schizophrenia, bipolar disorder or depression with psychotic ideation. However, recently a number of new possible indications have been suggested, among them Gilles de la Tourette syndrome (GTS). In two randomized, double-blind, placebo-controlled studies in children and adolescents with GTS has been confirmed the efficacy of aripiprazole in tic reduction...
November 9, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29153958/major-and-minor-life-events-personality-and-psychopathology-in-children-with-tourette-syndrome
#2
Netta Horesh, Sharona Shmuel-Baruch, Dan Farbstein, Daphna Ruhrman, Noa Ben Aroya Milshtein, Silvana Fennig, Alan Apter, Tamar Steinberg
Environmental, psychological, and biological interactions underlie many psychopathologies. Tourette's Syndrome (TS) has an obvious biological substrate but environmental factors and personality play substantial roles in its expression. We aimed to study the interrelationships between stressful life events, personality traits, tics, and comorbid disorders in children with TS. To this end, 132 children with TS and 49 healthy controls were recruited for the study. Major life events in the 12-months prior to testing and minor life events in the month prior to testing were retrospectively assessed using the Life Experiences Survey (LES) and the Brief Adolescent Life Events Scale (BALES), respectively...
November 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29152845/association-of-immp2l-deletions-with-autism-spectrum-disorder-a-trio-family-study-and-meta-analysis
#3
Yanqing Zhang, Yi Liu, Mehdi Zarrei, Winnie Tong, Rui Dong, Ying Wang, Haiyan Zhang, Xiaomeng Yang, Jeffrey R MacDonald, Mohammed Uddin, Stephen W Scherer, Zhongtao Gai
IMMP2L, the gene encoding the inner mitochondrial membrane peptidase subunit 2-like protein, has been reported as a candidate gene for Tourette syndrome, autism spectrum disorder (ASD) and additional neurodevelopmental disorders. Here we genotyped 100 trio families with an index proband with autism spectrum disorder in Han Chinese population and found three cases with rare exonic IMMP2L deletions. We have conducted a comprehensive meta-analysis to quantify the association of IMMP2L deletions with ASD using 5,568 cases and 10,279 controls...
November 20, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29151096/jumping-frenchmen-miryachit-and-latah-culture-specific-hyperstartle-plus-syndromes
#4
Douglas J Lanska
In the late 19th century, jumping (French Canadians in Maine, USA), miryachit (Siberia), and latah (Southeast Asia) were among a group of similar disorders described around the world, each of which manifests as an exaggerated startle response with additional late-response features that were felt by some to overlap with hysteria or tics. The later features following the exaggerated startle reaction variably include mimesis (e.g., echopraxia, echolalia) and automatic obedience. These reaction patterns tended to persist indefinitely in affected individuals...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29149614/risky-business-the-circuits-that-impact-stress-induced-decision-making
#5
Amy F T Arnsten, Daeyeol Lee, Christopher Pittenger
How does stress promote risky decision-making? Friedman et al. find that stress disrupts inhibition of striatal circuits by prefrontal cortex, rendering animals insensitive to potential losses. This may help explain how stress contributes to substance abuse and how it can disinhibit automatic behaviors, such as tics in Tourette syndrome.
November 16, 2017: Cell
https://www.readbyqxmd.com/read/29132817/a-national-description-of-treatment-among-united-states-children-and-adolescents-with-attention-deficit-hyperactivity-disorder
#6
Melissa L Danielson, Susanna N Visser, Andrea Chronis-Tuscano, George J DuPaul
OBJECTIVE: To characterize lifetime and current rates of attention-deficit/hyperactivity disorder (ADHD) treatments among US children and adolescents with current ADHD and describe the association of these treatments with demographic and clinical factors. STUDY DESIGN: Data are from the 2014 National Survey of the Diagnosis and Treatment of ADHD and Tourette Syndrome, a follow-back survey of parents from the 2011-2012 National Survey of Children's Health. Weighted analyses focused on receipt of ADHD treatment among children aged 4-17 years with current ADHD (n = 2495) by 4 treatment types: medication, school supports, psychosocial interventions, and alternative treatments...
November 10, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29132463/-serum-levels-of-25-hydroxyvitamin-d-in-children-with-tic-disorders
#7
Hong-Hua Li, Bing Wang, Ling Shan, Cheng-Xin Wang, Fei-Yong Jia
OBJECTIVE: To examine serum 25-hydroxyvitamin D levels in children with tic disorders (TD) and to explore the relationship between vitamin D level and TD. METHODS: One hundred and thirty-two children who were diagnosed with TD between November 2016 and May 2017 were enrolled as the TD group, including 8 cases of Tourette syndrome, 32 cases of chronic TD, and 92 cases of transient TD. One hundred and forty-four healthy children served as the control group. Peripheral venous blood samples were collected from each child...
November 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29131391/complex-genetics-of-tourette-s-syndrome-piecing-the-puzzle
#8
Aparna Wagle Shukla, Susan Fox
No abstract text is available yet for this article.
November 13, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29101846/single-unit-activity-of-the-anterior-globus-pallidus-internus-in-tourette-patients-and-posterior-globus-pallidus-internus-in-dystonic-patients
#9
Andrea Giorni, François Windels, Peter G Stratton, Raymond Cook, Paul Silberstein, Terrence Coyne, Peter A Silburn, Pankaj Sah
OBJECTIVES: Our goal was to provide a detailed analysis of neurons' electrophysiological activity recorded in sub-territories of Globus pallidus internus (GPi) used as Deep Brain Stimulation (DBS) targets for these clinical conditions to potentially assist electrode targeting. METHODS: We used intra-operative microelectrode recording during stereotactic neurosurgery to guide implantation of DBS lead. RESULTS: Units in the medial anterior part of GPi of 7 Tourette's syndrome patients under general anesthesia were firing at mean and median rate of 32...
December 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29100073/synaptic-neurexin-complexes-a-molecular-code-for-the-logic-of-neural-circuits
#10
REVIEW
Thomas C Südhof
Synapses are specialized junctions between neurons in brain that transmit and compute information, thereby connecting neurons into millions of overlapping and interdigitated neural circuits. Here, we posit that the establishment, properties, and dynamics of synapses are governed by a molecular logic that is controlled by diverse trans-synaptic signaling molecules. Neurexins, expressed in thousands of alternatively spliced isoforms, are central components of this dynamic code. Presynaptic neurexins regulate synapse properties via differential binding to multifarious postsynaptic ligands, such as neuroligins, cerebellin/GluD complexes, and latrophilins, thereby shaping the input/output relations of their resident neural circuits...
November 2, 2017: Cell
https://www.readbyqxmd.com/read/29098466/prevalence-and-predictors-of-hair-pulling-disorder-and-excoriation-disorder-in-tourette-syndrome
#11
Erica Greenberg, Esther S Tung, Caitlin Gauvin, Lisa Osiecki, Kelly G Yang, Erin Curley, Angela Essa, Cornelia Illmann, Paul Sandor, Yves Dion, Gholson J Lyon, Robert A King, Sabrina Darrow, Matthew E Hirschtritt, Cathy L Budman, Marco Grados, David L Pauls, Nancy J Keuthen, Carol A Mathews, Jeremiah M Scharf
Trichotillomania/hair pulling disorder (HPD) and excoriation/skin picking disorder (SPD) are childhood-onset, body-focused repetitive behaviors that are thought to share genetic susceptibility and underlying pathophysiology with obsessive-compulsive disorder (OCD) and Tourette syndrome (TS). We sought to determine the prevalence of DSM-5 HPD and SPD in TS patients, and to identify clinical factors most associated with their co-morbidity with TS. Participants included 811 TS patients recruited from TS specialty clinics for a multi-center genetic study...
November 2, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29077140/-deep-brain-stimulation-in-psychiatry
#12
M Figee, C Bervoets, D Denys
BACKGROUND: Deep brain stimulation (DBS) is now used regularly to treat therapy-refractory obsessive-compulsive disorders, and is being applied experimentally for refractory depression, Tourette syndrome, addiction, eating disorders, post-traumatic stress disorder, autism and schizophrenia. AIM: To review the effects and mechanisms of dbs and to consider the future opportunities for this type of treatment in psychiatry. METHOD: We reviewed the literature using PubMed...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/29075205/editorial-the-neurobiology-and-genetics-of-gilles-de-la-tourette-syndrome-new-avenues-through-large-scale-collaborative-projects
#13
EDITORIAL
Peristera Paschou, Kirsten Müller-Vahl
No abstract text is available yet for this article.
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29073741/a-systematic-review-of-the-effectiveness-of-medical-cannabis-for-psychiatric-movement-and-neurodegenerative-disorders
#14
REVIEW
Keane Lim, Yuen Mei See, Jimmy Lee
The discovery of endocannabinoid's role within the central nervous system and its potential therapeutic benefits have brought forth rising interest in the use of cannabis for medical purposes. The present review aimed to synthesize and evaluate the available evidences on the efficacy of cannabis and its derivatives for psychiatric, neurodegenerative and movement disorders. A systematic search of randomized controlled trials of cannabis and its derivatives were conducted via databases (PubMed, Embase and the Cochrane Central Register of Controlled Trials)...
November 30, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29061872/medical-cannabinoids-in-children-and-adolescents-a-systematic-review
#15
REVIEW
Shane Shucheng Wong, Timothy E Wilens
CONTEXT: Legalization of medical marijuana in many states has led to a widening gap between the accessibility and the evidence for cannabinoids as a medical treatment. OBJECTIVE: To systematically review published reports to identify the evidence base of cannabinoids as a medical treatment in children and adolescents. DATA SOURCES: Based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a search of PubMed, Medline, and the Cumulative Index to Nursing and Allied Health Literature databases was conducted in May 2017...
November 2017: Pediatrics
https://www.readbyqxmd.com/read/29061327/receipt-of-medication-and-behavioral-therapy-among-a-national-sample-of-school-aged-children-diagnosed-with-adhd
#16
Morgan Walls, Caitlin Allen, Howard Cabral, Lewis E Kazis, Megan Bair-Merritt
Objective In 2011, the American Academy of Pediatrics published practice guidelines for ADHD, recommending both medication and behavioral therapy for school-aged children. The current study examines associations between child/family characteristics and ADHD medication, behavioral, and combined therapy. Methods This study used data from the 2014 National Survey of the Diagnosis and Treatment of ADHD and Tourette Syndrome, a nationally-representative follow-up survey to the 2011-2012 National Survey of Children's Health...
October 20, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/29060866/a-marked-point-process-approach-for-identifying-neural-correlates-of-tics-in-tourette-syndrome
#17
Carlos A Loza, Jonathan B Shute, Jose C Principe, Michael S Okun, Aysegul Gunduz
We propose a novel interpretation of local field potentials (LFP) based on a marked point process (MPP) framework that models relevant neuromodulations as shifted weighted versions of prototypical temporal patterns. Particularly, the MPP samples are categorized according to the well known oscillatory rhythms of the brain in an effort to elucidate spectrally specific behavioral correlates. The result is a transient model for LFP. We exploit data-driven techniques to fully estimate the model parameters with the added feature of exceptional temporal resolution of the resulting events...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29057070/tourette-syndrome-research-highlights-from-2016
#18
REVIEW
Kevin J Black
This article presents highlights chosen from research that appeared during 2016 on Tourette syndrome and other tic disorders. Selected articles felt to represent meaningful advances in the field are briefly summarized.
2017: F1000Research
https://www.readbyqxmd.com/read/29053770/tourette-syndrome-a-disorder-of-the-social-decision-making-network
#19
Roger L Albin
Tourette syndrome is a common neurodevelopmental disorder defined by characteristic involuntary movements, tics, with both motor and phonic components. Tourette syndrome is usually conceptualized as a basal ganglia disorder, with an emphasis on striatal dysfunction. While considerable evidence is consistent with these concepts, imaging data suggest diffuse functional and structural abnormalities in Tourette syndrome brain. Tourette syndrome exhibits features that are difficult to explain solely based on basal ganglia circuit dysfunctions...
August 22, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053637/progress-in-genetic-studies-of-tourette-s-syndrome
#20
REVIEW
Yanjie Qi, Yi Zheng, Zhanjiang Li, Lan Xiong
Tourette's Syndrome (TS) is a complex disorder characterized by repetitive, sudden, and involuntary movements or vocalizations, called tics. Tics usually appear in childhood, and their severity varies over time. In addition to frequent tics, people with TS are at risk for associated problems including attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety, depression, and problems with sleep. TS occurs in most populations and ethnic groups worldwide, and it is more common in males than in females...
October 20, 2017: Brain Sciences
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