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https://www.readbyqxmd.com/read/28631249/molecular-characterisation-of-a-novel-isoform-of-hepatic-antimicrobial-peptide-hepcidin-le-hepc-from-leiognathus-equulus-and-analysis-of-its-functional-properties-in-silico
#1
Aishwarya Nair, K S Sruthy, E R Chaithanya, T P Sajeevan, I S Bright Singh, Rosamma Philip
Hepcidin represents a family of cysteine-rich antimicrobial peptides that are mainly expressed in the liver of living organisms. In this study, we have identified and characterised a novel isoform of hepcidin from the common pony fish, Leiognathus equulus (Le-Hepc). A 261-bp fragment cDNA coding for 86 amino acids was obtained. Homologous analysis showed that Le-Hepc belongs to the hepcidin super family and shares sequence identity with other known fish pre-propeptide hepcidin sequences. The ORF encodes for a 24-amino acid (aa) signal peptide coupled to a 36-aa prodomain followed by a 26-aa mature peptide...
June 19, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28629515/mutual-cross-talk-between-iron-homeostasis-and-erythropoiesis
#2
Ilona Rybinska, Gaetano Cairo
Iron is necessary for physiological processes essential for the activity of all cells, but the erythropoietic compartment is a privileged iron consumer. In fact, a considerable amount of iron is daily required for hemoglobin synthesis and erythroid cell proliferation. Therefore, a tight link exists between iron metabolism and erythropoiesis. The iron needed for hemoglobin synthesis is mainly ensured by inhibiting hepcidin expression, thereby increasing both ferroportin-mediated iron export from the duodenal absorptive cells and iron release from the reticuloendothelial cells that process old and/or damaged red blood cells...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28628474/prediction-of-human-iron-bioavailability-using-rapid-c-elisas-for-human-plasma-hepcidin
#3
Nicole U Stoffel, Christophe Zeder, Eloïse Fort, Dorine W Swinkels, Michael B Zimmermann, Diego Moretti
BACKGROUND: Hepcidin is the central systemic regulator of iron metabolism, but its quantification in biological fluids is challenging. Rapid, accurate and user-friendly methods are needed. Our aim was to assess the ability of hepcidin as measured by three different c-ELISA assays to predict iron bioavailability in humans. METHODS: The three assays used were commercially available DRG and Peninsula assays and the c-ELISA method performed at Radboud University Medical Centre, Nijmegen, The Netherlands (Hepcidinanalysis...
June 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28627405/the-effects-of-dietary-leucine-on-the-growth-performances-body-composition-metabolic-abilities-and-innate-immune-responses-in-black-carp-mylopharyngodon-piceus
#4
Chenglong Wu, Lian Chen, Zhibin Lu, Jun'e Gao, Yudan Chu, Liang Li, Ming Wang, Geying Zhang, Miaotong Zhang, Jinyun Ye
The present study was focused on the growth, body composition, metabolic abilities and innate immune responses in juvenile black carp Mylopharyngodon piceus fed with six levels of dietary leucine (7.3, 12.4, 16.2, 21.9, 28.3 and 34.5 g kg(-1)) for 9 weeks. Results showed that the highest weight gain (WG) and the lowest feed conversion ratio (FCR) was obtained at 23.5 and 23.9 g kg(-1) dietary leucine using second-order polynomial model, respectively. Adequate dietary leucine content (21.9 and 28.3 g kg(-1)) could significantly up-regulate the expression levels of neuropeptide Y (NPY) and ghrelin (GRL) in the brain of black carp juveniles...
June 13, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28625088/mitochondrial-content-and-hepcidin-are-increased-in-obese-pregnant-mothers
#5
G M Anelli, M Cardellicchio, C Novielli, P Antonazzo, M I Mazzocco, I Cetin, C Mandò
OBJECTIVE: Maternal obesity is characterized by systemic low-grade inflammation and oxidative stress (OxS) with the contribution of fetal sex dimorphism. We recently described increased mitochondrial content (mtDNA) in placentas of obese pregnancies. Here we quantify mtDNA and hepcidin as indexes of OxS and systemic inflammation in the obese maternal circulation. METHODS: Forty-one pregnant women were enrolled at elective Caesarean section: 16 were normal-weight [NW] and 25 were obese (OB)...
June 18, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28622783/-biological-diagnosis-of-iron-deficiency-in-children
#6
I Thuret
Measurement of serum ferritin (SF) is currently the laboratory test recommended for diagnosing iron deficiency. In the absence of an associated disease, a low SF value is an early and highly specific indicator of iron deficiency. The WHO criteria proposed to define depleted storage iron are 12μg/L for children under 5 years and 15μg/L for those over 5 years. A higher threshold of 30μg/L is used in the presence of infection or inflammation. Iron deficiency anemia, with typical low mean corpuscular volume and mean corpuscular hemoglobin, is only present at the end stage of iron deficiency...
May 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28622780/-iron-metabolism
#7
S Vaulont
Iron is an essential trace element ensuring many functions in the body. However, excess iron can be toxic with deleterious consequences on function and tissue integrity. The understanding of the molecular and cellular mechanisms allowing iron level to be kept at physiological concentration has greatly progressed in recent years, in particular with the identification of the iron-regulatory hormone, hepcidin and its receptor ferroportin, the sole iron exporter known to date. This discovery has improved our ability to diagnose and manage iron disorders and offered new therapeutic perspectives for an important class of human diseases...
May 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28622776/-iron-and-susceptibility-to-infections
#8
L de Pontual
Iron is essential for proper functioning of the host immune system as well as an essential nutrient for growth of various pathogens. Iron deficiency increases infection susceptibility, specially those due to intracellular pathogens. At the opposite, excess iron stores could increase the virulence of some pathogens. Hepcidin synthesis is increased during the acute inflammation phase; leading to decreased iron intestinal absorption and retention of the metal within macrophages. This is considered to result from a defense mechanism of the child to limit the availability of iron for extracellular pathogens...
May 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28622535/vitamin-d-mediates-the-relationship-between-placental-cathelicidin-and-group-b-streptococcus-colonization-during-pregnancy
#9
Christine C Akoh, Eva K Pressman, Corrie M Whisner, Carrie Thomas, Chang Cao, Tera Kent, Elizabeth Cooper, Kimberly O O'Brien
Vitamin D is thought to modulate innate immune responses, and recent studies have highlighted the autocrine and paracrine functions of vitamin D in the placenta. Our objective was to determine the relationship between maternal vitamin D status and placental antimicrobial peptide (AMP) expression in a group of racially and ethnically diverse pregnant adolescents. In this study, 158 pregnant adolescents were recruited from the Rochester Adolescent Maternity Program (RAMP) in Rochester, NY. Maternal serum concentrations of the vitamin D biomarkers, 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D), were measured at mid-gestation (∼26 weeks) and at delivery...
June 6, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28620062/urine-biomarkers-to-predict-response-to-lupus-nephritis-therapy-in-children-and-young-adults
#10
Hermine I Brunner, Michael R Bennett, Gaurav Gulati, Khalid Abulaban, Marisa S Klein-Gitelman, Stacy P Ardoin, Lori B Tucker, Kelly A Rouster-Stevens, David Witte, Jun Ying, Prasad Devarajan
OBJECTIVE: To delineate urine biomarkers that forecast response to therapy of lupus nephritis (LN). METHODS: Starting from the time of kidney biopsy, patients with childhood-onset systemic lupus erythematosus who were diagnosed with LN were studied serially. Levels of 15 biomarkers were measured in random spot urine samples, including adiponectin, α-1-acid glycoprotein (AGP), ceruloplasmin, hemopexin, hepcidin, kidney injury molecule 1, monocyte chemotactic protein-1, lipocalin-like prostaglandin D synthase (LPGDS), transforming growth factor-β (TGF-β), transferrin, and vitamin D binding protein (VDBP)...
June 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28618852/low-vitamin-d-is-associated-with-infections-and-proinflammatory-cytokines-during-pregnancy
#11
Christine C Akoh, Eva K Pressman, Elizabeth Cooper, Ruth Anne Queenan, Julie Pillittere, Kimberly O O'Brien
Vitamin D is known to regulate innate and adaptive immune processes at the cellular level, but the role of vitamin D status on associated inflammatory processes across pregnancy is unclear. Our primary objective was to evaluate the relationships between serum biomarkers of inflammation (interleukin [IL]-6, IL-10, tumor necrosis factor [TNF]-α), acute-phase proteins (C-reactive protein and hepcidin) and vitamin D status, 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D), measured across pregnancy and in the neonate at birth...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28615456/iron-homeostasis-an-anthropocentric-perspective
#12
Richard Coffey, Tomas Ganz
The regulation of iron metabolism in biological systems centers on providing adequate iron for cellular function while limiting iron toxicity. Because mammals cannot excrete iron, mechanisms have evolved to control iron acquisition, storage, and distribution at both systemic and cellular levels. Hepcidin, the master regulator of iron homeostasis, controls iron flows into plasma through inhibition of the sole known mammalian cellular iron exporter ferroportin. Hepcidin is feedback-regulated by iron status, and strongly modulated by inflammation and erythropoietic demand...
June 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28615455/minireview-prologue-introduction-metals-in-biology-2017-iron-transport-storage-and-the-ramifications
#13
F Peter Guengerich
In this tenth Thematic Series in Metals in Biology, five Minireviews deal with aspects of iron metabolism. A number of important proteins control iron homeostasis, including hepcidin and ferroportin, in various cells. Other aspects of iron dealt with here include biogenesis of iron-sulfur proteins and chaperones that deliver iron cofactors in cells. Additionally, an iron-regulated metastasis suppressor interacts with the epidermal growth factor receptor and mediates its downstream signaling activity.
June 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28615441/iron-transport-proteins-gateways-of-cellular-and-systemic-iron-homeostasis
#14
Mitchell D Knutson
Cellular iron homeostasis is maintained by iron and heme transport proteins that work in concert with ferrireductases, ferroxidases, and chaperones to direct the movement of iron into, within, and out of cells. Systemic iron homeostasis is regulated by the liver-derived peptide hormone, hepcidin. The interface between cellular and systemic iron homeostasis is readily observed in the highly dynamic iron handling of four main cell types: duodenal enterocytes, erythrocyte precursors, macrophages, and hepatocytes...
June 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28605609/effects-of-macro-and-micro-nutrients-on-exercise-induced-hepcidin-response-in-highly-trained-endurance-athletes
#15
Dylan Timothy Dahlquist, Trent Stellingwerff, Brad Pendleton Dieter, Donald C McKenzie, Michael S Koehle
Iron deficiency (ID) has ergolytic effects on athletic performance. Exercise induced inflammation impedes iron absorption in the digestive tract by up-regulating the expression of the iron regulatory protein, hepcidin. Limited research indicates the potential of specific macro- and micro- nutrients on blunting exercise induced hepcidin. Therefore, we investigated the effects of post-exercise supplementation with protein and carbohydrate (CHO) and vitamins D3 and K2 on the post-exercise hepcidin response. Ten highly-trained male cyclists (age: 26...
June 12, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28604755/physical-exercise-intervention-at-school-improved-hepcidin-inflammation-and-iron-metabolism-in-overweight-and-obese-children-and-adolescents
#16
Susana Coimbra, Cristina Catarino, Henrique Nascimento, Ana Inês Alves, Ana Filipa Medeiros, Elsa Bronze-da-Rocha, Elísio Costa, Petronila Rocha-Pereira, Luísa Aires, André Seabra, Jorge Mota, Helena Ferreira Mansilha, Carla Rêgo, Alice Santos-Silva, Luís Belo
BACKGROUND: Obesity is often associated with iron deficiency in children and adolescents. We aimed to study the effect of 8-month physical exercise (PE) intervention in hepcidin and other markers of inflammation and in iron status in overweight/obese children and adolescents. METHODS: Seventy-three overweight/obese children and adolescents participated in the 8-month longitudinal study; they were divided in two groups according to their participation in an after-school PE program: PE (n=44) and control (n=29) groups...
June 12, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28604512/changes-in-hepcidin-and-hemoglobin-after-anti-tnf-alpha-therapy-in-children-and-adolescents-with-crohn-s-disease
#17
Meredith A Atkinson, Mary B Leonard, Rita Herskovitz, Robert N Baldassano, Michelle R Denburg
BACKGROUND: Anemia is the most common systemic complication of inflammatory bowel disease, is more common in affected children than adults, and is mediated in large part by chronic inflammation. Inflammation increases levels of the iron-regulatory protein hepcidin, which have been elevated in adults with Crohn's disease. METHODS: We measured serum hepcidin-25 and hemoglobin (Hgb) in 40 children and adolescents with Crohn's disease at baseline and 10 weeks after initiation of anti-TNF-α therapy...
June 9, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28601871/perinatal-factors-affecting-serum-hepcidin-levels-in-low-birth-weight-infants
#18
Kenji Ichinomiya, Kenichi Maruyama, Takahiro Inoue, Aya Koizumi, Fumitaka Inoue, Kazuyo Fukuda, Yu Yamazaki, Hirokazu Arakawa
BACKGROUND: Hepcidin, an iron-regulatory hormone, plays a key role in preventing iron overload. Few studies have investigated the regulation of hepcidin in low-birth-weight (LBW) infants who are vulnerable to iron imbalance. OBJECTIVES: To identify perinatal factors associated with serum hepcidin levels in LBW infants. METHODS: Ninety-two LBW infants with a median gestational age (GA) of 32.6 weeks and birth weight of 1,587 g were prospectively enrolled...
June 10, 2017: Neonatology
https://www.readbyqxmd.com/read/28600663/serum-hepcidin-as-a-diagnostic-marker-of-severe-iron-overload-in-beta-thalassemia-major
#19
Ahmed Maher Kaddah, Amina Abdel-Salam, Marwa Salah Farhan, Reham Ragab
OBJECTIVES: To investigate potential usefulness of serum hepcidin in the diagnosis of iron overload in children with β-thalassemia. METHODS: A study was conducted on 30 thalassemia major (TM), 30 thalassemia intermedia (TI) and 60 healthy children as controls. Serum hepcidin was measured by Human Hepcidin, ELISA Kit. RESULTS: β-thalassemia patients had a higher serum hepcidin compared to the controls (p < 0.001). TM group had higher hepcidin and ferritin compared to the TI group (p = 0...
June 10, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28594937/hyperferritinemia-and-hypergammaglobulinemia-predict-the-treatment-response-to-standard-therapy-in-autoimmune-hepatitis
#20
Richard Taubert, Matthias Hardtke-Wolenski, Fatih Noyan, Claudine Lalanne, Danny Jonigk, Jerome Schlue, Till Krech, Ralf Lichtinghagen, Christine S Falk, Verena Schlaphoff, Heike Bantel, Luigi Muratori, Michael P Manns, Elmar Jaeckel
Autoimmune hepatitis (AIH) is a chronic hepatitis with an increasing incidence. The majority of patients require life-long immunosuppression and incomplete treatment response is associated with a disease progression. An abnormal iron homeostasis or hyperferritinemia is associated with worse outcome in other chronic liver diseases and after liver transplantation. We assessed the capacity of baseline parameters including the iron status to predict the treatment response upon standard therapy in 109 patients with untreated AIH type 1 (AIH-1) in a retrospective single center study...
2017: PloS One
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