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https://www.readbyqxmd.com/read/28433529/antimicrobial-peptides-within-the-yellowtail-kingfish-seriola-lalandi
#1
Simon Muncaster, Kirsty Kraakman, Olivia Gibbons, Koen Mensink, Maria Forlenza, Gregory Jacobson, Steve Bird
A number of Seriola species are currently farmed or being investigated as future aquaculture species in countries around the world. However they face a number of issues and limitations which will need to be overcome to ensure future stability and growth, one of which are disease outbreaks. Despite this, very little has been done to understand the immune system of Seriola species and very few immune genes have been characterised. Antimicrobial peptides (AMP) are naturally occurring low molecular weight polypeptides that play a major role in an organism's immune system and act effectively as a first line of defence...
April 19, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28428736/simple-sugar-supplementation-abrogates-exercise-induced-increase-in-hepcidin-in-young-men
#2
Maja Tomczyk, Jakub Kortas, Damian Flis, Wojciech Skrobot, Rafal Camilleri, Jedrzej Antosiewicz
BACKGROUND: At present many young people experience too much body iron accumulation. The reason of this phenomenon is not clear. There is accumulating evidences that not proper diet and lack of exercise could be a main contributing factors. This investigation assessed the effects of a diet rich in simple sugars (glucose or fructose) on exercise-induced hepcidin which is hormone regulating iron metabolism. METHODS: A group of physically active young men completed an incremental exercise test before and after a 3-day diet supplemented with fructose (4 g/kg BM) or glucose (4 g/kg BM)...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28427505/toxicity-of-iron-overload-and-iron-overload-reduction-in-the-setting-of-hematopoietic-stem-cell-transplantation-for-hematologic-malignancies
#3
REVIEW
Heather A Leitch, Eitan Fibach, Eliezer Rachmilewitz
Iron is an essential element for key cellular metabolic processes. However, transfusional iron overload (IOL) may result in significant cellular toxicity. IOL occurs in transfusion dependent hematologic malignancies (HM), may lead to pathological clinical outcomes, and IOL reduction may improve outcomes. In hematopoietic stem cell transplantation (SCT) for HM, IOL may have clinical importance; endpoints examined regarding an impact of IOL and IOL reduction include transplant-related mortality, organ function, infection, relapse risk, and survival...
May 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28426710/change-in-iron-metabolism-in-rats-after-renal-ischemia-reperfusion-injury
#4
Guang-Liang Xie, Lin Zhu, Yan-Min Zhang, Qian-Nan Zhang, Qing Yu
Previous studies have indicated that hepcidin, which can regulate iron efflux by binding to ferroportin-1 (FPN1) and inducing its internalization and degradation, acts as the critical factor in the regulation of iron metabolism. However, it is unknown whether hepcidin is involved in acute renal ischemia/reperfusion injury (IRI). In this study, an IRI rat model was established via right renal excision and blood interruption for 45 min in the left kidney, and iron metabolism indexes were examined to investigate the change in iron metabolism and to analyze the role of hepcidin during IRI...
2017: PloS One
https://www.readbyqxmd.com/read/28424258/serum-hepcidin-concentrations-decline-during-pregnancy-and-may-identify-iron-deficiency-analysis-of-a-longitudinal-pregnancy-cohort-in-the-gambia
#5
Amat Bah, Sant-Rayn Pasricha, Momodou W Jallow, Ebrima A Sise, Rita Wegmuller, Andrew E Armitage, Hal Drakesmith, Sophie E Moore, Andrew M Prentice
Background: Antenatal anemia is a risk factor for adverse maternal and fetal outcomes and is prevalent in sub-Saharan Africa. Less than half of antenatal anemia is considered responsive to iron; identifying women in need of iron may help target interventions. Iron absorption is governed by the iron-regulatory hormone hepcidin.Objective: We sought to characterize changes in hepcidin and its associations with indexes of iron stores, erythropoiesis, and inflammation at weeks 14, 20, and 30 of gestation and to assess hepcidin's diagnostic potential as an index of iron deficiency...
April 19, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28421792/micronutrient-supplementation-in-gastric-bypass-surgery-prospective-study-on-in%C3%AF-ammation-and-iron-metabolism-in-premenopausal-women
#6
Flávia Andréia Marin, Rozangela Verlengia, Alex Harley Crisp, Patrícia Fátima Sousa Novais, Irineu Rasera-Junior, Maria Rita Marques De Oliveira
BACKGROUND: Low-grade chronic inflammation in morbid obesity is associated with impaired iron metabolism. Bariatric surgery is effective in weight loss; however, it can induce specific nutritional deficiencies, such as iron, especially in premenopausal women. Alternatively, after surgery, there is an improvement in systemic inflammation, raising questions concerning the dosages of micronutrient supplementation. OBJECTIVES: This study aimed to assess the effect of two micronutrient supplementation schemes before and 6 months after a Roux-en-Y gastric bypass (RYGB) surgery on inflammation and iron metabolism in premenopausal women...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28420664/the-uk-cardiac-and-vascular-surgery-interventional-anaemia-response-caviar-study-protocol-for-an-observational-cohort-study-to-determine-the-impact-and-effect-of-preoperative-anaemia-management-in-cardiac-and-vascular-surgical-patients
#7
Marisa Chau, Toby Richards, Caroline Evans, Anna Butcher, Timothy Collier, Andrew Klein
INTRODUCTION: Preoperative anaemia is linked to poor postsurgical outcome, longer hospital stays, greater risk of complications and mortality. Currently in the UK, some sites have developed anaemia clinics or pathways that use intravenous iron to correct iron deficiency anaemia prior to surgery as their standard of care. Although intravenous iron has been observed to be effective in a variety of patient settings, there is insufficient evidence in its use in cardiac and vascular patients...
April 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28417923/anemia-in-kawasaki-disease-hepcidin-as-a-potential-biomarker
#8
REVIEW
Ying-Hsien Huang, Ho-Chang Kuo
Kawasaki disease (KD) is an autoimmune-like disease and acute childhood vasculitis syndrome that affects various systems but has unknown etiology. In addition to the standard diagnostic criteria, anemia is among the most common clinical features of KD patients and is thought to have a more prolonged duration of active inflammation. In 2001, the discovery of a liver-derived peptide hormone known as hepcidin began revolutionizing our understanding of anemia's relation to a number of inflammatory diseases, including KD...
April 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28416170/hepcidin-serum-levels-and-resistance-to-recombinant-human-erythropoietin-therapy-in-hemodialysis-patients
#9
Kristina Petrulienė, Edita Žiginskienė, Vytautas Kuzminskis, Irena Nedzelskienė, Inga Arūnė Bumblytė
OBJECTIVE: The aim of this study was to analyze the factors that are associated with the response to erythropoiesis-stimulating agents (ESAs) and its association with hospitalization and mortality rates; to evaluate the serum hepcidin level and its associations with iron profile, inflammatory markers, ESA responsiveness, and mortality; and to determine independent factors affecting ERI and hepcidin. MATERIALS AND METHODS: To evaluate a dose-response effect of ESAs we used the erythropoietin resistance index (ERI)...
March 31, 2017: Medicina
https://www.readbyqxmd.com/read/28412770/anemia-in-chronic-kidney-disease
#10
Meredith A Atkinson, Bradley A Warady
Anemia is common and associated with adverse outcomes in children with chronic kidney disease (CKD). Many factors contribute to declining hemoglobin as CKD progresses, but impaired production of erythropoietin by failing kidneys is a central cause. Hepcidin-mediated iron restriction also contributes to anemia by downregulating both intestinal iron absorption and release of stored iron for erythropoiesis. The core components of anemia management remain erythropoiesis-stimulating agents (ESA) and iron supplementation, but despite these therapies, a substantial number of children remain anemic...
April 15, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28411684/in-vivo-antimalarial-activity-of-synthetic-hepcidin-against-plasmodium-berghei-in-mice
#11
Ya-Qun Fang, Chuan-Bin Shen, Ning Luan, Hui-Min Yao, Chen-Bo Long, Ren Lai, Xiu-Wen Yan
The present study was designed to investigate the antimalarial activity of synthetic hepcidin and its effect on cytokine secretion in mice infected with Plasmodium berghei. The mice were infected with P. berghei intravenously and treated with hepcidin according to 4-day suppression test and Rane's test. The serum levels of interleukins (IL-1β, IL-2, IL-6, IL-10, IL-12p70, and IL-17A), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) in the experimental mice were determined using a cytometric bead array (CBA) kit...
March 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28409396/factors-influencing-the-post-exercise-hepcidin-25-response-in-elite-athletes
#12
Peter Peeling, Alannah K A McKay, David B Pyne, Kym J Guelfi, Rachel H McCormick, Coby M Laarakkers, Dorine W Swinkels, Laura A Garvican-Lewis, Megan L R Ross, Avish P Sharma, Jill J Leckey, Louise M Burke
PURPOSE: The extent to which hepcidin regulation after acute bouts of exercise is influenced by baseline (resting) concentrations of key iron parameters remains uncertain. This investigation explored the influence of selected iron parameters and 25-km race walk time on 3-h post-exercise hepcidin-25 levels in international-level race walkers. METHODS: Twenty-four male race walkers completed a graded exercise test and a 25-km race-walk trial. Throughout the 25-km race-walk, venous blood samples were collected pre-exercise, immediately post-exercise, and at 3-h post-exercise...
April 13, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28405918/hepcidin-suppression-in-%C3%AE-thalassemia-is-associated-with-the-down-regulation-of-atonal-homolog-8
#13
Supranee Upanan, Andrew T McKie, Gladys O Latunde-Dada, Sittiruk Roytrakul, Chairat Uthaipibull, Peraphan Pothacharoen, Prachya Kongtawelert, Suthat Fucharoen, Somdet Srichairatanakool
Atonal homolog 8 (ATOH8) is defined as a positive regulator of hepcidin transcription, which links erythropoietic activity with iron-sensing molecules. In the present study, we investigated the association between hepcidin and ATOH8 expression in β-thalassemia. We found that inhibition of hepcidin expression in β-thalassemia is correlated with reduced ATOH8 expression. Hepatic hepcidin 1 (Hamp1) and Atoh8 mRNA expression were down-regulated in β-thalassemic mice. Hepcidin (HAMP) and ATOH8 mRNA expression were consistently suppressed in Huh7 cells cultured in medium supplemented with β-thalassemia patient serum...
April 12, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28401620/atp4a-autoimmunity-in-pediatric-patients-with-type-1-diabetes-and-its-relationship-to-blood-count-iron-metabolism-and-vitamin-b12
#14
Agata Chobot, Ewa Rusak, Janet Wenzlau, Howard Davidson, Piotr Adamczyk, Agnieszka Krzywicka, Bogdan Mazur, Joanna Polańska, Marian Rewers
OBJECTIVE: We aimed to assess the prevalence of autoantibodies against the 4A subunit of the gastric proton pump (ATP4A) in pediatric type 1 diabetes (T1D) patients and explore the relationship between ATP4A positivity and blood cell count, iron turnover, and vitamin B12 concentration. SUBJECTS: The study included 94 (59% female) T1D children (aged 12.5 ± 4.1 years, T1D duration 4.2 ± 3.6 years, HbA1c 7.3 ± 1.5% (57 ± 12.6 mmol/mol) with no other autoimmune diseases...
April 12, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28400987/serum-hepcidin-levels-iron-dyshomeostasis-and-cognitive-loss-in-alzheimer-s-disease
#15
Zohara Sternberg, Zihua Hu, Daniel Sternberg, Shayan Waseh, Joseph F Quinn, Katharine Wild, Kaye Jeffrey, Lin Zhao, Michael Garrick
This pilot study examined the status of the master iron regulatory peptide, hepcidin, and peripheral related iron parameters in Alzheimer's disease (AD) and mild cognitive impairment patients, and evaluated the relationship between iron dyshomeostasis and amyloid-beta (Aβ), cognitive assessment tests, neuroimaging and clinical data. Frozen serum samples from the Oregon Tissue Bank were used to measure serum levels of hepcidin, ferritin, Aβ40, Aβ42 using enzyme-linked immunosorbent assay. Serum transferrin levels were determined indirectly as total iron binding capacity, serum iron was measured and the percent saturation of transferrin calculated...
April 2017: Aging and Disease
https://www.readbyqxmd.com/read/28397746/non-anticoagulant-heparins-are-hepcidin-antagonists-for-the-treatment-of-anemia
#16
REVIEW
Maura Poli, Michela Asperti, Paola Ruzzenenti, Annamaria Naggi, Paolo Arosio
The peptide hormone hepcidin is a key controller of systemic iron homeostasis, and its expression in the liver is mainly regulated by bone morphogenetic proteins (BMPs), which are heparin binding proteins. In fact, heparins are strong suppressors of hepcidin expression in hepatic cell lines that act by inhibiting the phosphorylation of SMAD1/5/8 proteins elicited by the BMPs. The inhibitory effect of heparins has been demonstrated in cells and in mice, where subcutaneous injections of non-anticoagulant heparins inhibited liver hepcidin expression and increased iron bioavailability...
April 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28397053/applied-value-of-monitoring-serum-hepcidin-in-differential-diagnosis-of-infection-versus-tumor-fevers
#17
Ling Li, Jiang-Guo Zhang, Man-Zhi Zhao, Zhu-Hua Wu, Jian-Xin Song
The applied value of serum hepcidin in differential diagnosis of infection fevers versus tumor fevers was explored. A total of 432 fever patients were selected according to the domestic fever of unknown origin (FUO) diagnostic criteria from our hospital between June 2010 and November 2013. Venous blood samples were taken on the day 1, 5, 10 after admission. The infection group (98 cases) and the tumor group (50 cases) were set up based on the clinical and laboratory findings. ELISA was used to determine the serum hepcidin and IL-6 levels...
April 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28392117/biomarkers-of-functional-outcome-in-intracerebral-hemorrhage-interplay-between-clinical-metrics-cd163-and-ferritin
#18
Andrew L A Garton, Vivek P Gupta, Brandon R Christophe, E Sander Connolly
BACKGROUND: Intracerebral hemorrhage (ICH) is associated with neurological decline and poor prognosis. Although many etiologic models have been explored, secondary damage caused by continued inflammation and iron exposure from red blood cell lysis may explain poor outcomes at distant follow-up. Examining serum samples of patients with ICH for biomarkers of iron physiology may yield relationships between iron exposure and functional outcomes. METHODS: The following study retrospectively evaluated 41 patient serum samples obtained 1 day and 7 days post-ictus for CD163, ferritin, and hepcidin concentrations...
April 5, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28387022/systemic-iron-homeostasis-and-erythropoiesis
#19
REVIEW
George Papanikolaou, Kostas Pantopoulos
Iron is an essential nutrient that is potentially toxic due to its redox reactivity. Insufficient iron supply to erythroid cells, the major iron consumers in the body, leads to various forms of anemia. On the other hand, iron overload (hemochromatosis) is associated with tissue damage and diseases of liver, pancreas, and heart. Physiological iron balance is tightly controlled at the cellular and systemic level by iron regulatory proteins (IRP1, IRP2) and the iron regulatory hormone hepcidin, respectively. Underlying mechanisms often intersect to achieve optimal iron utilization, to control immune responses, and to prevent iron toxicity...
April 6, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28385785/imatinib-and-spironolactone-suppress-hepcidin-expression
#20
Katarzyna Mleczko-Sanecka, Ana Rita da Silva, Debora Call, Joana Neves, Nikolai Schmeer, Georg Damm, Daniel Seehofer, Martina U Muckenthaler
Disorders of iron metabolism are largely attributed to an excessive or insufficient expression of hepcidin, the master regulator of systemic iron homeostasis. Here, we investigated whether drugs targeting genetic regulators of hepcidin can affect iron homeostasis. We focused our efforts on drugs approved for clinical use to enable repositioning strategies and/or to reveal iron-related side effects of widely prescribed therapeutics. To identify hepcidin-modulating therapeutics, we reevaluated data generated by a genome-wide RNAi screen for hepcidin regulators...
April 6, 2017: Haematologica
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