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Gastroesophageal reflux disease (GERD)

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https://www.readbyqxmd.com/read/28644349/filaggrin-and-periostin-expression-is-altered-in-eosinophilic-esophagitis-and-normalized-with-treatment
#1
Ekaterini Politi, Aspasia Angelakopoulou, Dimitra Grapsa, Maria Zande, Kalliopi Stefanaki, Ioanna Panagiotou, Eleftheria Roma, Ekaterini Syrigou
OBJECTIVES: Previous data have suggested that filaggrin (FLG) and periostin (POSTN) genes may be dysregulated in eosinophilic esophagitis (EoE). We aimed to further evaluate the expression patterns of FLG and POSTN proteins in esophageal tissue samples of patients with EoE, as compared to those of patients with gastroesophageal reflux disease (GERD) and normal controls. METHODS: A total of 61 prospectively collected cases, including 40 children with EoE and 21 children with GERD, and a control group of 14 sex- and age-matched healthy children were enrolled...
July 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28644313/unique-clinical-features-of-los-angeles-grade-d-esophagitis-suggest-that-factors-other-than-gastroesophageal-reflux-contribute-to-its-pathogenesis
#2
Anh D Nguyen, Stuart J Spechler, Monique N Shuler, Rhonda F Souza, Kerry B Dunbar
BACKGROUND: The Los Angeles (LA) grade of reflux esophagitis (A to D) is assumed to reflect severity of the underlying gastroesophageal reflux disease (GERD). Thus, LA-D esophagitis patients might be expected to have the most conditions predisposing to GERD (eg, obesity, hiatal hernia), and the highest frequency of GERD symptoms. GOALS: The main goal of this study is to compare clinical features of patients with the most severe (LA-D) and mildest (LA-A) grades of esophagitis...
June 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28638010/-evaluating-an-effectiveness-of-surgical-treatment-of-gastroesophageal-reflux-disease-combined-with-hiatal-hernia
#3
V V Mozharovskiy, A A Tsyganov, K V Mozharovskiy, A A Tarasov
AIM: To assess an effectiveness of surgical treatment of gastroesophageal reflux disease (GERD) combined with hiatal hernia (HH). MATERIAL AND METHODS: The trial included 96 patients with GERD and HH who were divided into 2 groups. The principal difference between groups was the use of surgery in the main group and therapeutic treatment in the comparison group. RESULTS: The effectiveness of surgical treatment is superior to therapeutic treatment of GERD by more than 2...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28636735/salivary-epidermal-growth-factor-concentrations-in-patients-with-sj%C3%A3-gren-syndrome-and-laryngopharyngeal-reflux
#4
Claudia A Eckley, Marco Antônio Dos Anjos Corvo, Luis Roberto Sardinha, Bianca Liquidato, Luiz Vicente Rizzo
Sjögren syndrome was chosen as a clinical model to study acinar salivary deficiencies in the development of laryngopharyngeal reflux (LPR). The objective of this prospective cohort study was to compare salivary epidermal growth factor (EGF) concentrations of patients with Sjögren syndrome with and without LPR and gastroesophageal reflux disease (GERD) with normal controls. LPR was diagnosed with positive scores on the Reflux Symptom Index and Reflux and Reflux Finding Score, corroborated by esophagogastroduodenoscopy and/or 24-hour pH-metry...
June 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28635907/-the-problem-of-obstructive-sleep-apnea-syndrome-in-asthmatic-patients
#5
E G Sheludko, D E Naumov, Yu M Perelman, V P Kolosov
Asthma and obstructive sleep apnea syndrome (OSAS) are one of the most common chronic respiratory diseases. These have common risk factors that include obesity, gastroesophageal reflux disease (GERD) and impaired nasal breathing (allergic rhinitis, sinusitis). At the same time, experimental evidence demonstrates common pathophysiological mechanisms of these diseases, such as involvement in the process of the respiratory tract, a systemic inflammatory response, and implementation of neuromechanical reflexes...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28626103/-study-on-lifestyle-in-patients-with-gastroesophageal-%C3%A2-reflux-disease
#6
Lingzhi Yuan, Dan Tang, Jin Peng, Nanfang Qu, Chun Yue, Fen Wang
To investigate the correlation between certain unhealthy lifestyles and the incidence of gastroesophageal reflux disease (GERD), thus to provide the lifestyle guidelines for GERD patients.
 Methods: Retrospective study were conducted for 402 GERD and 276 non-GERD out-patients in Department of Gastroenterology, Third Xiangya Hospital, Central South University from August, 2014 to August, 2015 based on questionnaire survey, then the correlation of unhealthy lifestyles with GERD were analyzed.
 Results: The top 10 common symptoms for GERD were as follows: reflux, acid regurgitation, postprandial fullness, heartburn, swallow obstruction or pain, epigastric burning sensation, paraesthesia pharynges, poststernal pain, chronic laryngopharyngitis, and chronic cough...
May 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28623447/new-approaches-to-gastroesophageal-reflux-disease
#7
William Kethman, Mary Hawn
BACKGROUND: Gastroesophageal reflux disease (GERD) is the most common gastrointestinal disorder of the esophagus. It is a chronic, progressive disorder that presents most typically with heartburn and regurgitation and atypically with chest pain, dysphagia, chronic cough, globus, or sore throat. The mainstay for diagnosis and characterization of the disorder is esophagoduodenoscopy (EGD), high-resolution esophageal manometry, and symptom-associated ambulatory esophageal pH impedance monitoring...
June 16, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28622974/survey-of-the-adherence-to-the-consensus-of%C3%A2-gastroesophageal-reflux-disease-before-and-after-the-implementation-course
#8
Jyh-Ming Liou, Bor-Shyang Sheu, Yi-Chia Lee, Hsiu-Chi Cheng, Wei-Lun Chang, Deng-Chyang Wu, Ping-I Hsu, Chun-Ying Wu, Ming-Shiang Wu, Cheng-Tang Chiu, Jaw-Town Lin
BACKGROUND/PURPOSE: The prevalence of Gastroesophageal reflux disease (GERD) is increasing worldwide, including Asia. Although several consensus reports have been published, little is known regarding the adherence of the physicians on the consensus of GERD. We aimed to survey the agreements and adherence of physicians to the Taiwan GERD consensus before and after the continual medical education (CME) courses. METHODS: Two-hundred and twenty-seven physicians, including 81 fellows of gastroenterology, 135 qualified gastroenterologists, and 11 non-gastroenterologist attending physicians were invited to the CME course...
June 13, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28609821/endoscopic-accessories-used-for-more-advanced-endoluminal-therapeutic-procedures
#9
REVIEW
Hyunsoo Chung
Endoscopic accessories describe an extensive variety of auxiliary instruments used for diagnostic and therapeutic endoscopy. Various endoscopic accessories have been developed over the previous few decades and are mostly used for treating neoplastic lesions, such as early gastrointestinal (GI) carcinomas and premalignant lesions. Because of extensive research on natural orifice endoluminal surgery (NOTES) in the early 2000s and recent technological developments, new devices have been developed for various advanced endoluminal therapeutic procedures...
May 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28607547/omeprazole-domperidone-fixed-dose-combination-vs-omeprazole-monotherapy-a-phase-4-open-label-comparative-parallel-randomized-controlled-study-in-mild-to-moderate-gastroesophageal-reflux-disease
#10
K Y Marakhouski, G A Karaseva, D N Ulasivich, Y Kh Marakhouski
AIM: To compare the efficacy and safety of omeprazole-domperidone combination vs omeprazole monotherapy in gastroesophageal reflux disease (GERD). METHODS: In a comparative, randomized controlled, phase 4 study, outpatients with GERD were randomly allocated to either group 1 (omeprazole 20 mg + domperidone 30 mg) or group 2 (omeprazole 20 mg) in an equal ratio; 2 capsules daily in the morning were administered for 8 weeks. RESULTS: Sixty patients were enrolled...
2017: Clinical Medicine Insights. Gastroenterology
https://www.readbyqxmd.com/read/28607289/a-long-term-evaluation-of-the-quality-of-life-after-laparoscopic-nissen-rossetti-anti-reflux-surgery
#11
Giovanni Alemanno, Carlo Bergamini, Paolo Prosperi, Alessandro Bruscino, Ancuta Leahu, Riccardo Somigli, Jacopo Martellucci, Andrea Valeri
BACKGROUND: The quality of life (QoL) has been suggested to be the most relevant parameter to assess and monitor the long-term outcome in patients who underwent surgery for gastroesophageal reflux disease (GERD). PATIENTS AND METHODS: A retrospective evaluation was conducted on patients who underwent Laparoscopic Nissen-Rossetti Fundoplication for GERD between January 1998 and December 2010. To evaluate the long-term results a telephone interview was made using the VISICK score and the GERD-health-related QoL (HRQL) questionnaire at 1, 3, 5 years and at the end of the study...
July 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28593484/reflux-sleeve-dilation-and-barrett-s-esophagus-after-laparoscopic-sleeve-gastrectomy-long-term-follow-up
#12
Daniel Moritz Felsenreich, Ronald Kefurt, Martin Schermann, Philipp Beckerhinn, Ivan Kristo, Michael Krebs, Gerhard Prager, Felix B Langer
BACKGROUND: Laparoscopic sleeve gastrectomy (SG) has become the most frequently performed bariatric procedure worldwide. De novo reflux might impact patients' quality of life, requiring lifelong proton pump inhibitor medication. It also increases the risk of esophagitis and formation of Barrett's metaplasia. Besides weight regain, gastroesophageal reflux disease (GERD) is the most common reason for conversion to Roux-en-Y gastric bypass. METHODS: We performed 24-h pH metries, manometries, gastroscopies, and questionnaires focusing on reflux (GIQLI, RSI) in SG patients with a follow-up of more than 10 years who did not suffer from symptomatic reflux or hiatal hernia preoperatively...
June 8, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28591070/emerging-gastrointestinal-and-liver-diseases-in-asia-pacific-implications-to-health-care-in-the-region-world-gastroenterology-organization-asian-pacific-association-of-gastroenterology-distinguished-global-lecture-2015
#13
Khean-Lee Goh
Colorectal cancer (CRC), gastroesophageal reflux disease (GERD), inflammatory bowel disease (IBD), and nonalcoholic fatty liver disease are considered important emerging diseases in the Asia Pacific (AP) region. The incidence rate of CRC is the highest among gastrointestinal cancers in the region surpassing that of gastric cancer. However, population CRC screening is limited by availability of adequate health resources and financing. GERD is a highly prevalent disease in AP with the prevalence of GERD symptoms and reflux esophagitis reported to be increasing...
July 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28591069/world-gastroenterology-organisation-global-guidelines-gerd-global-perspective-on-gastroesophageal-reflux-disease
#14
Richard Hunt, David Armstrong, Peter Katelaris, Mary Afihene, Abate Bane, Shobna Bhatia, Min-Hu Chen, Myung Gyu Choi, Angelita Cristine Melo, Kwong Ming Fock, Alex Ford, Michio Hongo, Aamir Khan, Leonid Lazebnik, Greger Lindberg, Maribel Lizarzabal, Thein Myint, Joaquim Prado Moraes-Filho, Graciela Salis, Jaw Town Lin, Raj Vaidya, Abdelmounen Abdo, Anton LeMair
No abstract text is available yet for this article.
July 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28586287/esophageal-penetration-of-the-magnetic-sphincter-augmentation-device-history-repeats-itself
#15
Renato Salvador, Mario Costantini, Giovanni Capovilla, Lino Polese, Stefano Merigliano
BACKGROUND: An alternative approach to the treatment of gastroesophageal reflux disease (GERD) has recently been introduced in clinical practice, involving the implantation of a magnetic sphincter augmentation device (MSAD). This "magnetic ring" is implanted laparoscopically around the lower esophageal sphincter to improve its barrier function. The literature is still limited on the midterm results achieved in controlling reflux because the MSAD is a very new procedure. So far, only a few cases of the MSAD causing erosion of the esophagus have been reported...
June 6, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28574384/-evaluation-of-quality-indicators-of-life-as-a-criterion-of-the-efficiency-of-treatment-for-liquidators-of-the-accident-at-chernobyl-aerosphorus-patients-with-hypertension-disease-comorbid-with-gastroesophageal-reflux-disease
#16
V Synelnik, A Oparin
In order to assess the quality of life of liquidators of the accident at the Chernobyl nuclear power plant (CHPP) of patients with hypertensive comorbid disease with gastroesophageal reflux disease, 52 patients aged 46 to 71 years (mean age 57.5±0, 8 years old) who were on inpatient treatment in the therapeutic department of the Regional Clinical Specialized Dispensary for Radiation Protection of the Population of Kharkov from January 2016 to December 2016. The men among the examined were 44 (84.6%), women - 8 (15...
April 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28571180/gastroesophageal-reflux-disease-and-its-association-with-body-mass-index-clinical-and-endoscopic-study
#17
Bhumika Vaishnav, Arvind Bamanikar, Pragati Maske, Anudeep Reddy, Sukanya Dasgupta
INTRODUCTION: Obesity is rapidly becoming a pandemic and poses a serious health risk to the individuals. Abdominal obesity is quite common in India and is a prime risk factor for diseases like diabetes, coronary artery disease, Gastroesophageal Reflux Disease (GERD), osteoarthritis etc. A complex and multifactorial aetiopathogenesis of GERD exists in presence of obesity. The current study focuses on high Body Mass Index (BMI), a marker of obesity, as a risk factor for GERD and aims for a better understanding of their complex association...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28569739/endoscopic-guided-measurement-of-mucosal-admittance-can-discriminate-gastroesophageal-reflux-disease-from-functional-heartburn
#18
Tomoaki Matsumura, Hideaki Ishigami, Mai Fujie, Takashi Taida, Shingo Kasamatsu, Kenichiro Okimoto, Keiko Saito, Daisuke Maruoka, Tomoo Nakagawa, Takeshi Suzuki, Tatsuro Katsuno, Makoto Arai
OBJECTIVES: A novel catheter that can measure mucosal admittance (MA), the inverse of impedance, was developed recently. In this pilot study, we aimed to clarify the usefulness of measuring MA for diagnosing gastroesophageal reflux disease (GERD). METHODS: We conducted two prospective studies. In the first study, esophageal MA was evaluated in 120 participants (24 with erosive esophagitis, 82 with heartburn but non-erosive esophagitis, and 14 healthy volunteers) and compared with the endoscopic findings...
June 1, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28568312/autoimmune-comorbidity-in-achalasia-patients
#19
Fernanda Romero-Hernández, Janette Furuzawa-Carballeda, Gabriela Hernández-Molina, Edgar Alejandro-Medrano, Carlos A Núñez-Álvarez, Diego F Hernández-Ramírez, Daniel Azamar-Llamas, Elizabeth Olivares-Martínez, Blanca Breña, Axel Palacios, Miguel A Valdovinos, Enrique Coss-Adame, Bárbara Ramos-Ávalos, Samuel Torres-Landa, Axel A Hernández-Ávila, Athenea Flores-Nájera, Gonzalo Torres-Villalobos
BACKGROUND: Idiopathic achalasia is a rare esophageal motor disorder. The disease state manifests local and systemic inflammation, and it appears that an autoimmune component and specific autoantibodies participate in the pathogenesis. AIM: To determine the prevalence of autoimmune and chronic inflammatory diseases in patients with achalasia and compare the results with those from patients with gastroesophageal reflux disease (GERD). METHODS: It was a cross-sectional and included 114 patients with idiopathic achalasia and 114 age-and sex-matched control patients with GERD...
May 31, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28557566/psychosocial-factors-are-associated-with-quality-of-life-after-laparoscopic-antireflux-surgery
#20
Alexa K Statz, Andrea M Stroud, Sally A Jolles, Jacob A Greenberg, Anne O Lidor, Amber L Shada, Xing Wang, Luke M Funk
BACKGROUND: Laparoscopic antireflux surgery (LARS) is the gold standard treatment for refractory gastroesophageal reflux disease (GERD). Traditional surgical outcomes following LARS are well described, but limited data exist regarding patient-reported outcomes. We aimed to identify preoperative characteristics that were independently associated with a high GERD health-related quality of life (GERD-HRQL) following LARS. METHODS: Clinical data from our single institution foregut surgery database were used to identify all patients with GERD who underwent primary LARS from June 2010 to November 2015...
May 30, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
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