keyword
Keywords Gastroesophageal reflux diseas...

Gastroesophageal reflux disease (GERD)

https://read.qxmd.com/read/38546507/exploring-the-clinical-relevance-of-angico-gum-an-effective-biopolymer-for-topical-protection-of-oesophageal-mucosa-in-gastroesophageal-reflux-disease-patients
#1
JOURNAL ARTICLE
Rudy Diavila Bingana, Lucas Antonio Duarte Nicolau, Thiago Meneses Araújo Leite Sales, Suliana Mesquita Paula, João Pedro do Carmo Neto, Isabela Araújo Linhares Castro, Luiz Fernando Lopes Soares Teixeira, Alvaro Xavier Franco, Fábio de Oliveira Silva Ribeiro, Regina Célia Monteiro de Paula, Jand Venes Rolim Medeiros, Durcilene Alves da Silva, Daniel Sifrim, Marcellus Henrique Loiola Ponte Souza
OBJECTIVES: Angico gum (AG) (Anadenanthera colubrina var. Cebil [Griseb.] Altschul) is utilized by some Brazilian communities to alleviate symptoms from gastroesophageal reflux disease. Here, we aimed to investigate the "in vitro" topical protective capacity of AG on human esophageal mucosa. METHODS: Biopsies of the distal esophageal mucosa were collected from 35 patients with heartburn (24 non-erosive and 11 with erosive oesophagitis (EE)) and mounted in Üssing chambers...
March 28, 2024: Journal of Pharmacy and Pharmacology
https://read.qxmd.com/read/38545007/comparison-of-efficacy-of-daily-and-alternate-day-maintenance-treatment-of-gerd-with-vonoprazan-10-mg-using-gastroesophageal-reflux-disease-symptom-assessment-scale
#2
JOURNAL ARTICLE
Tazeen Rasheed, Bader Faiyaz Zuberi, Faiza Sadaqat Ali, Sana Muhammad Hussain, Pawan Kumar, Anoshia Saleem
OBJECTIVES: To compare efficacy of 10-mg of vonoprazan daily & on alternate days by Gastroesophageal Reflux Disease Symptom Assessment Scale (GSAS). METHOD: This prospective interventional cohort was done at Department of Medicine/Gastroenterology Dow Medical College, Karachi, Pakistan during the period August 2022 & January 2023. Potential participants fulfilling inclusion and exclusion criteria were asked to fill out GSAS questionnaires after their written consent...
2024: Pakistan Journal of Medical Sciences Quarterly
https://read.qxmd.com/read/38541878/scoring-abdominal-symptoms-in-people-with-cystic-fibrosis
#3
REVIEW
Harold Tabori, Anton Barucha, Carlos Zagoya, Franziska Duckstein, Gabor A Dunay, Pauline Sadrieh, Louise Polte, Jochen G Mainz
(1) Background: The introduction of highly effective CFTR-modulating therapies (HEMT) has changed the course of the disease for many people with Cystic Fibrosis (pwCF). Attention previously focused on life-threatening conditions of the respiratory system has broadened, bringing the involvement of the digestive system into the clinical and scientific focus. This emphasized the need for sensitive tools to capture and quantify changes in abdominal symptoms (AS), ideally applying patient-reported outcome measures (PROMs)...
March 13, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541244/current-status-of-anti-reflux-surgery-as-a-treatment-for-gerd
#4
REVIEW
Jooyeon Lee, Inhyeok Lee, Youjin Oh, Jeong Woo Kim, Yeongkeun Kwon, Ahmad Alromi, Mohannad Eledreesi, Alkadam Khalid, Wafa Aljarbou, Sungsoo Park
Anti-reflux surgery (ARS) is an efficient treatment option for gastroesophageal reflux disease (GERD). Despite growing evidence of the efficacy and safety of ARS, medications including proton pump inhibitors (PPIs) remain the most commonly administered treatments for GERD. Meanwhile, ARS can be an effective treatment option for patients who need medications continuously or for those who are refractory to PPI treatment, if proper candidates are selected. However, in practice, ARS is often regarded as a last resort for patients who are unresponsive to PPIs...
March 21, 2024: Medicina
https://read.qxmd.com/read/38541131/a-three-arm-randomized-controlled-trial-of-primary-one-anastomosis-gastric-bypass-with-fundoring-or-nissen-fundoplications-vs-without-fundoplication-for-the-treatment-of-obesity-and-gastroesophageal-reflux-disease
#5
JOURNAL ARTICLE
Oral Ospanov, Nurlan Zharov, Bakhtiyar Yelembayev, Galymjan Duysenov, Irina Volchkova, Kassymkhan Sultanov, Adil Mustafin
Background and Objectives : Obesity and gastroesophageal reflux disease (GERD) are steadily increasing world weight and antireflux surgery must be performed simultaneously with bariatric surgery in obese patients. The purpose of this study is to compare bariatric and antireflux results after OAGB with different methods of fundoplication using the excluded stomach and without fundoplication. Materials and methods : This open-label, randomized, parallel three-arm trial was conducted from March 2019 and December 2021...
February 27, 2024: Medicina
https://read.qxmd.com/read/38539331/proton-pump-inhibitors-in-pediatric-gastroesophageal-reflux-disease-a-systematic-review-of-randomized-controlled-trials
#6
REVIEW
Sara María Fernández-González, Ana Moreno-Álvarez, Alfonso Solar-Boga
This systematic review was conducted with the objective of understanding the efficacy and safety of proton pump inhibitors (PPIs) in the pediatric population. We used PubMed to identify randomized controlled trials (RCTs) published between 1 June 2010 and 30 June 2023, performed in patients from birth to 18 years old with gastroesophageal reflux disease (GERD) who received treatment with any PPI. This literature search yielded 76 articles and 13 of these met the inclusion criteria. For infants, PPIs were equal to placebos in reducing GERD symptoms in four articles...
March 1, 2024: Children
https://read.qxmd.com/read/38536701/the-milan-score-a-novel-manometric-tool-for-a-more-efficient-diagnosis-of-gastro-esophageal-reflux-disease
#7
JOURNAL ARTICLE
Stefano Siboni, Marco Sozzi, Ivan Kristo, Sara Boveri, Benjamin D Rogers, Nicola De Bortoli, Anthony Hobson, Brian E Louie, Yeong Yeh Lee, Salvatore Tolone, Elisa Marabotto, Pierfrancesco Visaggi, Jordan Haworth, Megan L Ivy, Garrett Greenan, Takahiro Masuda, Roberto Penagini, Benedetta Barcella, Marina Coletta, Dimitrios Theodorou, Tania Triantafyllou, Chiara Facchini, Vincent Tee, Luigi Bonavina, Lorenzo Cusmai, Sebastian F Schoppmann, Edoardo Savarino, Emanuele Asti, C Prakash Gyawali
OBJECTIVE: A definitive diagnosis of gastroesophageal reflux disease (GERD) depends on endoscopic and/or pH-study criteria. However, high resolution manometry (HRM) can identify factors predicting GERD, such as ineffective esophageal motility (IEM), esophago-gastric junction contractile integral (EGJ-CI), evaluating esophagogastric junction (EGJ) type and straight leg raise (SLR) maneuver response. We aimed to build and externally validate a manometric score (Milan Score) to stratify the risk and severity of the disease in patients undergoing HRM for suspected GERD...
March 27, 2024: United European Gastroenterology Journal
https://read.qxmd.com/read/38536110/epidemiology-and-prognostic-significance-of-cough-in-fibrotic-interstitial-lung-disease
#8
JOURNAL ARTICLE
Yet H Khor, Kerri A Johannson, Veronica Marcoux, Jolene H Fisher, Deborah Assayag, Helene Manganas, Nasreen Khalil, Martin Kolb, Christopher J Ryerson
Rationale: Cough is a key symptom in patients with fibrotic interstitial lung disease (ILD). Objective: This study evaluated the prevalence, longitudinal change, associations, and prognostic significance of cough severity in patients with fibrotic ILD. Methods: We included consecutive patients with idiopathic pulmonary fibrosis (IPF) and non-IPF fibrotic ILD who completed the 100mm-Cough Severity Visual Analog Scale (VAS) from the prospective multi-center Canadian Registry for Pulmonary Fibrosis. Baseline cough severity and associations with patient demographics and clinical factors were determined...
March 27, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38534258/development-of-highly-sensitive-fluorescent-sensors-for-separation-free-detection-and-quantitation-systems-of-pepsin-enzyme-applying-a-structure-guided-approach
#9
JOURNAL ARTICLE
Aya M Mostafa, Stephen J Barton, Stephen P Wren, James Barker
Two fluorescent molecularly imprinted polymers (MIPs) were developed for pepsin enzyme utilising fluorescein and rhodamine b. The main difference between both dyes is the presence of two (diethylamino) groups in the structure of rhodamine b. Consequently, we wanted to investigate the effect of these functional groups on the selectivity and sensitivity of the resulting MIPs. Therefore, two silica-based MIPs for pepsin enzyme were developed using 3-aminopropyltriethoxysilane as a functional monomer and tetraethyl orthosilicate as a crosslinker to achieve a one-pot synthesis...
March 20, 2024: Biosensors
https://read.qxmd.com/read/38532588/-propensity-score-matching-analysis-of-the-short-term-efficacy-of-kamikawa-versus-double-tract-reconstruction-in-laparoscopic-proximal-gastric-cancer-surgery
#10
JOURNAL ARTICLE
H C Yang, J X He, Y Yang, Z Han, B Zhang, S Zhou, T Wu, Q Qiao, X L He, N Wang
Objective: To compare the short-term efficacy of Kamikawa anastomosis and double-tract reconstruction (DTR) after proximal gastrectomy. Methods: This was a propensity score matched, retrospective, cohort study. Inclusion criteria comprised age 20-70 years, diagnosis of gastric cancer by pathological examination of preoperative endoscopic biopsies, tumor diameter ≤4 cm, and location in the upper 1/3 of the stomach (including the gastroesophageal junction), and TNM stage IA, IB, or IIA. The study cohort comprised 73 patients who had undergone laparoscopic proximal gastric cancer radical surgery in the Department of Gastroenterology, Tangdu Hospital, Air Force Medical University between June 2020 and February 2023, 19 of whom were in the Kamikawa group and 54 in the DTR group...
March 25, 2024: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38529201/the-role-of-inflammatory-biomarkers-in-mediating-the-effect-of-inflammatory-bowel-disease-on-nonmalignant-digestive-system-diseases-a-multivariable-mendelian-randomized-study
#11
JOURNAL ARTICLE
Shu Zhou, Qi Sun, Ning Gao, Zekai Hu, Junjun Jia, Jiangwei Song, Guocong Xu, Aiqiang Dong, Weiliang Xia, Jiafeng Wu
BACKGROUND: While observation studies have shown a positive correlation between inflammatory bowel disease (IBD) and the risk of nonmalignant digestive system diseases, a definitive causal relationship has not yet been clearly established. METHODS: Mendelian randomization (MR) was employed to investigate the potential causal association between genetic susceptibility to IBD and nonmalignant gastrointestinal diseases. Genetic variants were extracted as instrumental variables (IVs) from a genome-wide association study (GWAS) meta-analysis, which included 12,194 cases of Crohn's disease (CD) and 28,072 control cases of European ancestry...
2024: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38528386/potassium-competitive-acid-blocker-versus-proton-pump-inhibitor-a-pilot-study-on-comparable-efficacy-in-the-treatment-of-gastroesophageal-reflux-related-cough
#12
JOURNAL ARTICLE
Shuxin Zhong, Mingyu Zhong, Liman Fang, Haopeng Zhi, Xiaolong Ji, Kailun Tang, Chen Zhan, Xu Shi, Mo Xian, Wanjun Wang, Jing Li, Wei Luo, Kefang Lai, Ruchong Chen
Acid inhibitors have been considered in treating gastroesophageal reflux-related cough (GERC). Compared to proton pump inhibitors (PPIs), potassium-competitive acid blockers (P-CABs) have more potent and durable effects on anti-acid secretion. However, whether vonoprazan and esomeprazole have different therapeutic effects on GERC remains unknown. Patients diagnosed with GERC were enrolled in our study and randomly treated with vonoprazan (20 mg, once daily, P-CAB) or esomeprazole (20 mg, twice daily, PPI) for two months...
March 2024: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/38528349/the-impact-of-gastric-juice-on-the-surface-roughness-of-surface-sealant-treated-provisional-restorations
#13
JOURNAL ARTICLE
Hy Yay Kuscu, I Kurkcuoglu, H C Kucukesmen
BACKGROUND AND AIM: Gastroesophageal reflux disease causes gastric acid to enter the oral cavity, leading to mucosal changes and deterioration of dental hard tissues and materials. The purpose of this in vitro study was to evaluate the impact of gastric juice on the surface roughness of two types of acrylics used in provisional restorations. MATERIALS AND METHODS: Acrytemp ® and Temdent acrylic resin discs (10 × 2 mm) totaling 80 were manufactured and divided into eight groups (n = 10)...
March 1, 2024: Nigerian Journal of Clinical Practice
https://read.qxmd.com/read/38528263/risk-factors-associated-with-functional-esophageal-disorders-fed-versus-gastroesophageal-reflux-disease-gerd
#14
JOURNAL ARTICLE
Moniyka Sachar, Marina Wizentier, Emma Risner, Hannah Asmail, Mathew Omara, Shreya Chablaney, Abraham Khan, Rita Knotts
INTRODUCTION: Despite the high prevalence of typical symptoms of gastroesophageal reflux disease (GERD), approximately 30% of patients have functional esophageal disorders (FED) on ambulatory reflux monitoring, which may include reflux hypersensitivity (RH; defined as physiologic acid exposure but temporally correlated symptoms of reflux), or functional heartburn (FH; defined as physiologic acid exposure and negative symptom correlation). There are limited epidemiological data characterizing these conditions...
March 25, 2024: Surgical Endoscopy
https://read.qxmd.com/read/38528208/saliva-production-and-esophageal-motility-influence-esophageal-acid-clearance-related-to%C3%A2-post-reflux-swallow-induced-peristaltic-wave
#15
JOURNAL ARTICLE
Lorenzo Marchetti, Benjamin D Rogers, Tricia Hengehold, Daniel Sifrim, C Prakash Gyawali
BACKGROUND: The post-reflux swallow-induced peristaltic wave (PSPW) brings salivary bicarbonate to neutralize residual distal esophageal mucosal acidification. AIMS: To determine if reduced saliva production and esophageal body hypomotility would compromise PSPW-induced pH recovery in the distal esophagus. METHODS: In this multicenter retrospective cross-sectional study, patients with confirmed Sjogren's syndrome and scleroderma/mixed connective tissue disease (MCTD) who underwent high resolution manometry (HRM) and ambulatory pH-impedance monitoring off antisecretory therapy were retrospectively identified...
March 25, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38525936/pilot-study-evaluating-salivary-bile-acids-as-a-diagnostic-biomarker-of-laryngopharyngeal-reflux
#16
JOURNAL ARTICLE
Amanda J Krause, Madeline Greytak, Marco Kessler, Rena Yadlapati
Bile acids in refluxate contribute to esophageal and laryngeal symptoms and are quantifiable. The aim of this study was to compare salivary bile acid concentrations across healthy controls and symptomatic patients (esophageal or laryngeal) with or without objective gastroesophageal reflux disease (GERD). This prospective study enrolled adults into three groups: esophageal symptoms (heartburn, regurgitation, chest pain); laryngeal symptoms (cough, throat clearing, sore throat, dysphonia); and controls. Symptomatic patients primarily underwent prolonged wireless reflux monitoring off acid suppression and were categorized as symptomatic no GERD (acid exposure time <4%) or esophageal/laryngeal symptoms with GERD (acid exposure time ≥4%)...
March 24, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38524789/patient-journey-in-gastroesophageal-reflux-disease-real-world-perspectives-from-italian-gastroenterologists-primary-care-physicians-and-ent-specialists
#17
JOURNAL ARTICLE
Andrea Pasta, Filippo Pelizzaro, Elisa Marabotto, Francesco Calabrese, Elena Formisano, Shirin Djahandideh Sheijani, Giovanni Brandimarte, Giampiero Manes, Antonietta Gerarda Gravina, Edoardo Vincenzo Savarino
BACKGROUND: Gastroesophageal reflux disease (GERD) is a challenging condition that involves different physicians, such as general practitioners (GPs), gastroenterologists, and ears, nose and throat (ENT) specialists. A common approach consists of proton-pump inhibitors (PPIs) administration. Adjunctive pharmacological treatment may have a role in the management of non-responders to PPIs. OBJECTIVES: We aimed to survey GPs and different medical specialists to investigate the medical approaches to patients reporting GERD symptoms...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38523886/efficacy-and-safety-of-peroral-endoscopic-myotomy-poem-in-achalasia-an-updated-meta-analysis
#18
JOURNAL ARTICLE
Afshin Khaiser, Muhammad Baig, David Forcione, Matthew Bechtold, Srinivas R Puli
Background: Heller myotomy has been considered the standard surgical treatment for patients with achalasia. Since the initiation of peroral endoscopic myotomy (POEM), it has represented an alternative for treating patients with achalasia. Over the years, numerous prospective and retrospective studies with POEM use for achalasia have been published. We performed a systematic review and meta-analysis to evaluate the efficacy and safety of POEM in patients with achalasia. Methods: Publications investigating the safety and efficacy of POEM in patients with achalasia were searched in Medline, Ovid Journals, Medline non-indexed citations, and Cochrane Central Register of Controlled Trials and Database of Systematic Reviews...
October 2023: Middle East Journal of Digestive Diseases
https://read.qxmd.com/read/38523885/predictors-of-pathological-gastroesophageal-reflux-among-emirati-patients-with-reflux-symptoms-who-undergo-wireless-ph-monitoring
#19
JOURNAL ARTICLE
Mostafa Ahmed Shehata, Talaha Aziz Malik, Mona Hassan Jasem Alzaabi, Ameirah Bader Abdullah Al Ali, Khalifa Saleh Ahmed Al Tenaiji, Yashbir Singh, Michael Bradley Wallace
Background: Diagnosis of gastroesophageal reflux disease (GERD) relies on recognizing symptoms of reflux and mucosal changes during esophagogastroduodenoscopy. The desired response to acid suppression therapy is reliable resolution of GERD symptoms; however, these are not always reliable, hence the need for pH testing in unclear cases. Our objective was to identify potential predictors of a high DeMeester score among patients with potential GERD symptoms to identify patients most likely to have pathological GERD...
October 2023: Middle East Journal of Digestive Diseases
https://read.qxmd.com/read/38523356/the-impact-of-lung-transplantation-on-esophageal-motility-and-inter-relationships-with-reflux-and-lung-mechanics-in-patients-with-restrictive-and-obstructive-respiratory-disease
#20
JOURNAL ARTICLE
Ali Alghubari, Ramsah Cheah, Sadia Z Shah, Abdel-Rahman N Naser, Augustine S Lee, Kenneth R DeVault, Lesley A Houghton
BACKGROUND: For many patients with lung disease the only proven intervention to improve survival and quality of life is lung transplantation (LTx). Esophageal dysmotility and gastroesophageal reflux (GER) are common in patients with respiratory disease, and often associate with worse prognosis following LTx. Which, if any patients, should be excluded from LTx based on esophageal concerns remains unclear. Our aim was to understand the effect of LTx on esophageal motility diagnosis and examine how this and the other physiological and mechanical factors relate to GER and clearance of boluses swallowed...
March 24, 2024: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
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