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Gastroesophageal reflux disease (GERD)

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https://www.readbyqxmd.com/read/28523363/systematic-review-and-meta-analysis-of-laparoscopic-mesh-versus-suture-repair-of-hiatus-hernia-objective-and-subjective-outcomes
#1
Chao Zhang, Diangang Liu, Fei Li, David I Watson, Xiang Gao, Jan H Koetje, Tao Luo, Chao Yan, Xing Du, Zhonggao Wang
BACKGROUND: Hiatus hernia (HH) contributes to the pathophysiology of gastroesophageal reflux disease (GERD). Mesh-augmentation of surgical repair might be associated with a reduced risk of recurrence and GERD. However, recurrence rates, mesh-associated complications and quality of life (QOL) after mesh versus suture repair are debated. The aim of this meta-analysis was to determine HH recurrence following mesh-augmentation versus suture repair. Secondary aims were to compare complications, mortality, QOL and GERD symptoms following different repair techniques...
May 18, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28523360/comparison-of-the-multichannel-intraluminal-impedance-ph-and-conventional-ph-for-measuring-esophageal-acid-exposure-a-propensity-score-matched-analysis
#2
Masato Hoshino, Nobuo Omura, Fumiaki Yano, Kazuto Tsuboi, Se Ryung Yamamoto, Shunsuke Akimoto, Takahiro Masuda, Hideyuki Kashiwagi, Katsuhiko Yanaga
BACKGROUND: The modalities for evaluating acid reflux in medical care for gastroesophageal reflux disease (GERD) include conventional pH (C-pH), wireless pH (Bravo(®)) and multichannel intraluminal impedance pH (MII-pH), which have been reported to vary with respect to the duration of acid reflux. In this study, we examined the difference between the acid reflux in C-pH and MII-pH among patients with GERD. METHODS: Prior to initial laparoscopic fundoplication carried out on 297 cases from December 1994 to April 2016, an upper gastrointestinal endoscopy and C-pH or MII-pH were conducted...
May 18, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28521729/self-rated-health-and-functional-capacity-in-individuals-reporting-overlapping-symptoms-of-gastroesophageal-reflux-disease-functional-dyspepsia-and-irritable-bowel-syndrome-a-population-based-study
#3
Dorte Ejg Jarbøl, Sanne Rasmussen, Kirubakaran Balasubramaniam, Sandra Elnegaard, Peter Fentz Haastrup
BACKGROUND: Gastroesophageal reflux disease (GERD), functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common functional gastrointestinal conditions with a significant impact on daily life. The objectives were to analyse general self-rated health and self-reported functional capacity in adults meeting the criteria for GERD, FD and IBS, respectively, and in individuals who meet the criteria for more than one of the conditions. METHODS: A nationwide study of 100,000 individuals aged 20 years and above, randomly selected in the general Danish population...
May 18, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28514401/-differentiation-therapy-for-non-acidic-gastroesophageal-reflux-disease
#4
N B Lishchuk, V I Simanenkov, S V Tikhonov
AIM: To investigate the clinical and pathogenetic features of the non-acidic types of gastroesophageal reflux disease (GERD) and to evaluate the impact of combined therapy versus monotherapy on the course of this disease. SUBJECTS AND METHODS: The investigation enrolled 62 patients with non-acidic GERD. The follow-up period was 6 weeks. The patients were divided into 2 groups: 1) weakly acidic gastroesophageal refluxes (GER); 2) weakly alkaline GER. Then each group was distributed, thus making up 4 groups: 1) 19 patients with weakly acidic GER who received monotherapy with rabeprazole 20 mg/day; 2) 21 patients with weakly acidic GER had combined therapy with rabeprazole 20 mg and itopride; 3) 8 patients with weakly alkaline GER who received ursodeoxycholic acid (UDCA) monotherapy; and 4) 14 patients with weakly alkaline GER who had combined therapy with UDCA and itopride, The clinical symptoms of the disease, the endoscopic pattern of the upper gastrointestinal tract (GIT) mucosa, histological changes in the esophageal and gastric mucosa, and the results of 24-hour impedance pH monitoring were assessed over time...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28514400/-comparative-characteristics-of-patients-with-gastroesophageal-reflux-disease-in-the-age-aspect
#5
O A Denisova, M A Livzan, A P Denisov
AIM: To compare the characteristics of patients with gastroesophageal reflux disease (GERD) by age groups, a wide range of clinical signs, including life-of-quality (QOL) indicators, and instrumental findings. SUBJECTS AND METHODS: A total of 110 patients aged 18 to 86 years with GERD were examined in accordance with the standard protocol. Two groups with equal numbers of patents were formed. A study group included elderly and senile patients and a control group consisted of young and adult ones...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28508234/surgical-treatment-of-extraesophageal-manifestations-of-gastroesophageal-reflux-disease
#6
REVIEW
Feroze Sidwa, Alessandra L Moore, Elaine Alligood, P Marco Fisichella
OBJECTIVE: To review the current literature on the role of antireflux surgery (ARS) for the treatment of extraesophageal manifestations of GERD. The extraesophageal manifestations of gastroesophageal reflux disease (GERD) include chronic cough, laryngopharyngeal reflux, and asthma. They are responsible for significant morbidity in affected patients and a high economic burden on healthcare resources. We recently published a larger review on the symptoms, diagnosis, medical, and surgical treatment of the extraesophageal manifestations of GERD...
May 15, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28507913/role-of-gastroesophageal-reflux-disease-in-lung-transplantation
#7
REVIEW
Kelly E Hathorn, Walter W Chan, Wai-Kit Lo
Lung transplantation is one of the highest risk solid organ transplant modalities. Recent studies have demonstrated a relationship between gastroesophageal reflux disease (GERD) and lung transplant outcomes, including acute and chronic rejection. The aim of this review is to discuss the pathophysiology, evaluation, and management of GERD in lung transplantation, as informed by the most recent publications in the field. The pathophysiology of reflux-induced lung injury includes the effects of aspiration and local immunomodulation in the development of pulmonary decline and histologic rejection, as reflective of allograft injury...
April 24, 2017: World Journal of Transplantation
https://www.readbyqxmd.com/read/28502434/gastroesophageal-reflux-disease
#8
REVIEW
Hayat Mousa, Maheen Hassan
Gastroesophageal reflux (GER) is a normal physiologic process. It is important to distinguish GER from GER disease (GERD) since GER does not require treatment. Although a diagnosis of GERD can largely be based on history and physical alone, endoscopy and pH impedance studies can help make the diagnosis when there in atypical presentation. In children and adolescents, lifestyle changes and acid suppression are first-line treatments for GERD. In infants, acid suppression is not effective, but a trial of hydrolyzed formula can be considered, as milk protein sensitivity can be difficult to differentiate from GER symptoms...
June 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/28501868/factors-associated-with-potassium-competitive-acid-blocker-non-response-in-patients-with-proton-pump-inhibitor-refractory-gastroesophageal-reflux-disease
#9
Masatsugu Okuyama, Kenichi Nakahara, Narika Iwakura, Tomoki Hasegawa, Maizumi Oyama, Ayumi Inoue, Hirotaka Ishizu, Hiroshi Satoh, Yasuhiro Fujiwara
BACKGROUND/AIMS: Approximately 20-40% of patients with gastroesophageal reflux disease (GERD) are refractory to proton pump inhibitor (PPI) treatment. The acid-inhibitory effect of vonoprazan, a novel potassium-competitive acid blocker (P-CAB), is significantly greater when compared to the effect of PPIs. We investigated the efficacy of vonoprazan treatment for PPI-refractory GERD and factors associated with P-CAB non-response. METHODS: We enrolled 277 GERD patients receiving continuous PPI therapy...
May 13, 2017: Digestion
https://www.readbyqxmd.com/read/28496527/correlation-between-symptom-severity-and-health-related-life-quality-of-a-population-with-gastroesophageal-reflux-disease
#10
Shou-Wu Lee, Teng-Yu Lee, Han-Chung Lien, Yen-Chun Peng, Hong-Jeh Yeh, Chi-Sen Chang
BACKGROUND: Gastroesophageal reflux disease (GERD) is a chronic disease with a negative impact on the quality of life. The aim of this study was to investigate the reflux symptoms and the health-related quality of life in a population with GERD. METHODS: Data from patients with GERD, according to the Montreal definition, were collected between January and December 2009. The enrolled patients were classified by different reflux symptoms according to the modified Chinese GERDQ...
April 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28495303/the-characteristics-of-salivary-pepsin-in-patients-with-severe-motor-and-intellectual-disabilities
#11
Naoki Hashizume, Suguru Fukahori, Kimio Asagiri, Shinji Ishii, Nobuyuki Saikusa, Naruki Higashidate, Motomu Yoshida, Daisuke Masui, Saki Sakamoto, Yoshiaki Tanaka, Minoru Yagi, Yushiro Yamashita
PURPOSE: The aim of the present study was to determine the utility of measuring the salivary pepsin level (SPL) as an objective assessment of gastroesophageal reflux disease (GERD) in severe motor and intellectual disabilities (SMID) patients. SUBJECTS AND METHODS: This prospective study included 26 SMID patients who underwent simultaneous 24-h multichannel intraluminal impedance pH measurement (pH/MII) and SPL evaluation. The enrolled patients were divided into GERD (+) or GERD (-) groups according to the pH/MII findings...
May 8, 2017: Brain & Development
https://www.readbyqxmd.com/read/28493043/revisional-surgery-after-failed-laparoscopic-sleeve-gastrectomy-retrospective-analysis-of-causes-results-and-technical-considerations
#12
Huseyin Yilmaz, Ilhan Ece, Mustafa Sahin
BACKGROUND: A failed laparoscopic sleeve gastrectomy (LSG) presents a challenging problem for bariatric surgeons. The aim of this study was to evaluate the indications, treatment strategies, and surgical outcomes of patients who underwent a revisional surgery after a failed LSG. METHODS: This retrospective study included the outcomes of 32 patients who required a revisional surgery from a series of 500 primary LSGs. The patients' demographic data, indications for revisional surgery, perioperative complications, and postoperative outcomes were recorded...
May 10, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28479737/flavonoids-from-whole-plant-of-euphorbia-hirta-and-their-evaluation-against-experimentally-induced-gastroesophageal-reflux-disease-in-rats
#13
Shyam Sundar Gupta, Lubna Azmi, P K Mohapatra, Ch V Rao
BACKGROUND: Euphorbia hirta possesses antibacterial, anti-inflammatory, galactogenic, antidiarrheal, antioxidant, hypoglycemic, antiasthmatic, antiamebic, antifungal, and antimalarial activities. OBJECTIVE: The overall objective of the current study was the investigation of the whole plant extract of E. hirta and flavonoids from E. hirta on gastroesophageal reflux disease (GERD) in rats. MATERIALS AND METHODS: The whole plant extract of E...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28475727/foregut-symptoms-somatoform-tendencies-and-the-selection-of-patients-for-antireflux-surgery
#14
K-H Fuchs, F Musial, F Ulbricht, W Breithaupt, A Reinisch, B Babic, H Fuchs, G Varga
A large variety of foregut symptoms can occur in patients with gastroesophageal reflux disease (GERD), which can overlap with other disorders such as somatoform disorders and dyspepsia. Due to unclear diagnostic situations, these patients are often not adequately treated. The aim of this study was the evaluation of patients with foregut symptoms, referred for possible antireflux surgery, regarding their relationship with GERD and somatization tendencies based on control data from an unselected population. Symptom evaluation and somatization screening were initiated both in volunteers and in patients with foregut symptoms and GERD...
July 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28474318/long-term-results-after-sleeve-gastrectomy-for-gastroesophageal-reflux-disease-a-single-center-french-study
#15
Etienne Chuffart, Maxime Sodji, François Dalmay, Antonio Iannelli, Muriel Mathonnet
BACKGROUND: Many studies have analyzed the impact of sleeve gastrectomy (SG) on weight loss and/or the evolution of obesity-related comorbid conditions, but few have reported the long-term outcomes after surgery. The objective of this study was to investigate the outcomes after SG on weight loss, obesity-related comorbid conditions, quality of life (QoL), and GERD symptoms (GERDS) beyond 5 years. METHODS: A prospective database was retrospectively searched for the following factors: gender, age, anthropometrics, presence of comorbid conditions, QoL (BAROS questionnaire), and presence of GERDS...
May 4, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28472017/systematic-review-and-meta-analysis-of-perioperative-outcomes-of-peroral-endoscopic-myotomy-poem-and-laparoscopic-heller-myotomy-lhm-for-achalasia
#16
Aiman Awaiz, Rossita M Yunus, Shahjahan Khan, Breda Memon, Muhammed A Memon
AIMS AND OBJECTIVES: Laparoscopic Heller myotomy (LHM) is the preferred surgical method for treating achalasia. However, peroral endoscopic myotomy (POEM) is providing good short-term results. The objective of this systematic review and meta-analysis was to compare the safety and efficacy of LHM and POEM. MATERIALS AND METHODS: A search of PubMed, Cochrane database, Medline, Embase, Science Citation Index, and current contents for English-language articles comparing LHM and POEM between 2007 and 2016 was performed...
May 3, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28471830/impact-of-gastroesophageal-reflux-disease-symptoms-on-the-quality-of-life-in-pregnant-women-a-prospective-study
#17
Sara Fill Malfertheiner, Birgit Seelbach-Göbel, Serban-Dan Costa, Wolfgang Ernst, Edith Reuschel, Florian Zeman, Peter Malfertheiner, Maximilian V Malfertheiner
OBJECTIVE: Pregnant women often suffer from gastroesophageal reflux disease (GERD). GERD symptoms are known to influence the quality of life; however, there is a lack of data in pregnant women. The aim of this study was to establish the impact of GERD symptoms on health-related quality of life (HRQOL) during pregnancy. PARTICIPANTS AND METHODS: A prospective longitudinal cohort study to investigate the impact of GERD symptoms on the HRQOL was carried out in 510 pregnant women and 330 nonpregnant women as controls...
May 3, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28471304/upper-esophageal-sphincter-abnormalities-and-high-resolution-esophageal-manometry-findings-in-patients-with-laryngopharyngeal-reflux
#18
Tanmayee Benjamin, Shamiq Zackria, Rocio Lopez, Joel Richter, Prashanthi N Thota
BACKGROUND: The association between laryngopharyngeal reflux (LPR) and abnormalities of upper esophageal sphincter (UES) and esophageal motility is not clearly known. High-resolution esophageal manometry (HREM) has allowed accurate measurement and evaluation of UES and esophageal function. GOALS: To evaluate the UES function and esophageal motility using HREM in patients with LPR and compare them to patients with typical gastroesophageal reflux disease (GERD). STUDY: All patients evaluated for GERD or LPR symptoms with esophageal function testing including HREM, ambulatory distal pH monitoring and upper endoscopy between 2006 and 2014 were retrospectively studied (n = 220)...
May 4, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28466002/efficacy-of-magnetic-sphincter-augmentation-versus-nissen-fundoplication-for-gastroesophageal-reflux-disease-in-short-term-a-meta-analysis
#19
REVIEW
Ming-Yu Chen, Di-Yu Huang, Angela Wu, Yi-Bin Zhu, He-Pan Zhu, Liu-Mei Lin, Xiu-Jun Cai
Background. The efficacy of Magnetic Sphincter Augmentation (MSA) and its outcomes for Gastroesophageal Reflux Disease (GERD) are uncertain. Therefore, we aimed to summarize and analyze the efficacy of two treatments for GERD. Methods. The meta-analysis search was performed, using four databases. All studies from 2005 to 2016 were included. Pooled effect was calculated using either the fixed or random effects model. Results. A total of 4 trials included 624 patients and aimed to evaluate the differences in proton-pump inhibitor use, complications, and adverse events...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28465782/comparative-study-of-outcomes-following-laparoscopic-roux-en-y-gastric-bypass-and-sleeve-gastrectomy-in-morbidly-obese-patients-a-case-control-study
#20
Harshit Garg, Pratyusha Priyadarshini, Sandeep Aggarwal, Samagra Agarwal, Rachna Chaudhary
AIM: To compare the impact of laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG) on weight loss and obesity related comorbidities over two year follow-up via case control study design. METHODS: Forty patients undergoing LRYGB, who completed their two year follow-up were matched with 40 patients undergoing LSG for age, gender, body mass index and presence of type 2 diabetes mellitus (T2DM). Data of these patients was retrospectively reviewed to compare the outcome in terms of weight loss and improvement in comorbidities, i...
April 16, 2017: World Journal of Gastrointestinal Endoscopy
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