Shuhei Yoshida, Tomohiro Koga, Yuya Fujita, Hiroshi Yatsuhashi, Haruki Matsumoto, Yuya Sumichika, Kenji Saito, Shuzo Sato, Tomoyuki Asano, Masao Kobayakawa, Hiromasa Ohira, Masashi Mizokami, Masaya Sugiyama, Kiyoshi Migita
BACKGROUND: Autoinflammation with cytokine dysregulation may be implicated in the pathophysiology of adult-onset Still's disease (AOSD); however, the relationship between galectins and cytokines in patients with active AOSD remains unknown. We aimed to examine the relationship between circulating cytokines/chemokines and galectin-3 (Gal-3) or its ligand, Mac-2 binding protein glycosylation isomer (M2BPGi), in Japanese patients with AOSD. METHODS: We recruited 44 consecutive patients diagnosed with AOSD according to the Yamaguchi criteria, 50 patients with rheumatoid arthritis (RA) as disease controls, and 27 healthy participants...
2024: Frontiers in Immunology