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arthritis rheumatoides

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https://www.readbyqxmd.com/read/29452423/anti-citrullinated-alpha-enolase-antibodies-interstitial-lung-disease-and-bone-erosion-in-rheumatoid-arthritis
#1
Alessia Alunno, Onelia Bistoni, Federico Pratesi, Giuliana Maria Concetta La Paglia, Ilaria Puxeddu, Paola Migliorini, Roberto Gerli
Objectives: RA is an articular chronic inflammatory disease that in a subgroup of patients can also present with extra-articular manifestations (EAMs). Despite intense investigation on this topic, reliable biomarkers for EAMs are lacking. In recent years several ACPAs, including those targeting anti-citrullinated alpha enolase peptide-1 (anti-CEP-1), have been identified in patients with RA. Data about the ability of anti-CEP-1 to predict the development of erosive disease are confliciting and no evidence concerning their possible association with EAMs in RA is currently available...
February 14, 2018: Rheumatology
https://www.readbyqxmd.com/read/29452300/therapeutic-strategy-for-rheumatoid-arthritis-patients-who-have-achieved-remission
#2
Bruno Fautrel
Once remission or low disease activity (LDA) is attained in established rheumatoid arthritis (RA) patients, attempting disease-modifying anti-rheumatic drug (DMARD) tapering appears to be a viable option to avoid patient overtreatment. Potential benefits include reduction in the treatment burden and the risk of adverse events, although the latter has not been demonstrated convincingly.The feasibility of DMARD discontinuation has been tested in numerous studies or trials. All have revealed a high risk of relapse, ranging from 56% to 87% at one year...
February 13, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29452286/risk-factor-analysis-of-adjacent-segment-disease-requiring-surgery-after-short-lumbar-fusion-the-influence-of-rheumatoid-arthritis
#3
Jin-Sung Park, Kyu-Dong Shim, Young-Sik Song, Ye-Soo Park
BACKGROUND CONTEXT: The influence of rheumatoid arthritis (RA) on the lumbar spine has received relatively little attention compared with cervical spine, and few studies have been conducted for adjacent segment disease (ASD) after lumbar fusion in the patients with RA. PURPOSE: To determine the incidence of ASD requiring surgery (ASDrS) after short lumbar fusion and to evaluate risk factors of ASDrS, including RA. STUDY DESIGN: Retrospective cohort study PATIENT SAMPLE: This study included 479 patients who underwent lumbar spinal fusion of 3 or fewer levels, with the mean follow-up period of 51...
February 13, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29451523/-towards-new-therapeutic-paradigms-beyond-symptom-control-in-the-management-of-inflammatory-bowel-diseases
#4
Stefano Festa, Giulia Zerboni, Annalisa Aratari, Riccardo Ballanti, Claudio Papi
Inflammatory bowel diseases, Crohn's disease and ulcerative colitis are chronic relapsing conditions that may result in progressive bowel damage, high risk of complications, surgery and permanent disability. The conventional therapeutic approach for inflammatory bowel diseases is based mainly on symptom control. Unfortunately, a symptom-based therapeutic approach has little impact on major long-term disease outcomes. In other chronic disabling conditions such as diabetes, hypertension and rheumatoid arthritis, the development of new therapeutic approaches has led to better outcomes...
January 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29451066/psychometric-properties-of-mdhaq-rapid3-in-patients-with-systemic-lupus-erythematosus
#5
N Annapureddy, D Giangreco, H Devilliers, J A Block, M Jolly
Background The Multidimensional Health Assessment Questionnaire (MDHAQ) is a patient-reported outcome (PRO) tool that includes the Routine Assessment of Patient Index Data 3 (RAPID3), an index that can be calculated at the point of care. The objective of this study was to perform psychometric analyses of MDHAQ/RAPID3 to study its measurement properties in systemic lupus erythematosus (SLE). Methods The MDHAQ was completed by 161 SLE patients in routine care, along with LupusPRO (a disease-specific PRO). The SLE disease-specific activity index (SELENA-SLEDAI) and damage (SDI) were assessed...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29450976/high-adherence-observed-to-system-level-performance-measures-for-rheumatoid-arthritis-in-a-national-early-arthritis-cohort-over-8-years
#6
Claire E H Barber, Orit Schieir, Diane Lacaille, Deborah A Marshall, Cheryl Barnabe, Glen Hazlewood, Carter Thorne, Vandana Ahluwalia, Susan J Bartlett, Gilles Boire, Boulos Haraoui, Carol A Hitchon, Edward Keystone, Diane Tin, Janet Pope, Lisa Denning, Vivian Bykerk
OBJECTIVE: To assess adherence to three System-Level Performance Measures in a national early RA (ERA) cohort. METHODS: Patients enrolled in the Canadian Early Arthritis Cohort (2007-2015) who met 1987 or 2010 ACR/EULAR criteria with <1year of symptom duration and ≥1year of follow-up after enrollment were included. Performance measures assessed were: i) the percentage of RA patients seen in yearly follow-up, and number of gaps between visits of >12 or 14 months, ii) the percentage of RA patients treated with a disease-modifying drug (DMARD) and, iii) days from RA diagnosis to initiation of DMARD...
February 16, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29450453/the-association-of-age-with-clinical-presentation-and-comorbidities-of-pyoderma-gangrenosum
#7
Hovik J Ashchyan, Daniel C Butler, Caroline A Nelson, Megan H Noe, William G Tsiaras, Stephen J Lockwood, William D James, Robert G Micheletti, Misha Rosenbach, Arash Mostaghimi
Importance: Pyoderma gangrenosum is an inflammatory neutrophilic dermatosis. Current knowledge of this rare disease is limited owing to a lack of validated diagnostic criteria and large population studies. Objective: To evaluate the association of age with the clinical presentation and comorbidities of pyoderma gangrenosum. Design, Setting, and Participants: This was a multicenter retrospective cohort study performed at tertiary academic referral centers in urban settings...
February 14, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29449499/clinical-correlates-outcomes-and-predictors-of-inflammatory-ocular-disease-associated-with-rheumatoid-arthritis-in-the-biologic-era
#8
Cristian Caimmi, Cynthia S Crowson, Wendy M Smith, Eric L Matteson, Ashima Makol
OBJECTIVE: Inflammatory ocular disease (IOD) is a rare but severe extraarticular manifestation of rheumatoid arthritis (ExRA) with high mortality. The aim of our study was to examine clinical characteristics of IOD in rheumatoid arthritis (RA) and their effect on disease severity and outcomes in recent years. METHODS: A retrospective cohort of RA patients with IOD evaluated between 1996 and 2013 was assembled and compared to RA comparators without IOD and matched for age, sex, and disease duration...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29449498/early-psoriatic-arthritis-versus-early-seronegative-rheumatoid-arthritis-role-of-dermoscopy-combined-with-ultrasonography-for-differential-diagnosis
#9
Alen Zabotti, Enzo Errichetti, Francesca Zuliani, Luca Quartuccio, Stefania Sacco, Giuseppe Stinco, Salvatore De Vita
OBJECTIVE: Exclusion of psoriatic skin/nail lesions is important in differentiating early seronegative rheumatoid arthritis (ERA) from early polyarticular psoriatic arthritis (EPsA) and such manifestations may go unnoticed in atypical or minimally expressed cases. The aim of this study is to assess the usefulness of integrated rheumatological-dermatological evaluation in highlighting dermatological lesions missed on rheumatological examination and to investigate the role of ultrasonography (US) and dermoscopy in improving the recognition of subclinical psoriatic findings...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29449497/rheumatologists-views-and-experiences-in-managing-rheumatoid-arthritis-in-elderly-patients-a-qualitative-study
#10
Jill Nawrot, Annelies Boonen, Ralph Peeters, Mirian Starmans, Marloes van Onna
OBJECTIVE: In this qualitative study we analyzed the (1) influence of age, comorbidity, and frailty on management goals in elderly patients with RA; (2) experiences of rheumatologists regarding the use of the Disease Activity Score at 28 joints (DAS28) to monitor disease activity; and (3) differences in management strategies in elderly patients with RA compared to their younger counterparts. METHODS: Rheumatologists were purposively sampled for a semistructured interview...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29449496/patient-reported-outcomes-resource-use-and-social-participation-of-patients-with-rheumatoid-arthritis-treated-with-biologics-in-alberta-experience-of-indigenous-and-non-indigenous-patients
#11
Cheryl Barnabe, Louise Crane, Tyler White, Brenda Hemmelgarn, Gilaad G Kaplan, Liam Martin, Walter P Maksymowych
OBJECTIVE: To characterize patient-reported outcomes, resource use, and social participation during the course of biologic therapy for indigenous and non-indigenous patients with rheumatoid arthritis (RA). METHODS: Patients initiating biologic therapy (2004 to 2012) were characterized longitudinally for patient-reported outcomes including physical function measured by the Health Assessment Questionnaire, EQ-5D, well-being [Medical Outcomes Study Short Form-36 (SF-36)], and visual analog scales for pain, fatigue, sleep, stiffness, and patient's global assessment...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29449195/neutrophil-microvesicles-from-healthy-control-and-rheumatoid-arthritis-patients-prevent-the-inflammatory-activation-of-macrophages
#12
Hefin I Rhys, Francesco Dell'Accio, Costantino Pitzalis, Adrian Moore, Lucy V Norling, Mauro Perretti
Microvesicles (MVs) are emerging as a novel means to enact cell-to-cell communication in inflammation. Here, we aimed to ascertain the ability of neutrophil-derived MVs to modulate target cell behaviour, the focus being the macrophage. MVs were generated in response to tumour necrosis factor-α, from healthy control neutrophils or those from rheumatoid arthritis patients. MVs were used to stimulate human monocyte-derived macrophages in vitro, or administered intra-articularly in the K/BxN mouse model of arthritis...
February 7, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29449068/chemokines-beyond-chemo-attraction-cxcl10-and-its-significant-role-in-cancer-and-autoimmunity
#13
Nathan Karin, Hila Razon
Chemokines are mostly known for their chemotactic properties, and less for their ability to direct the biological function of target cells, including T cells. The current review focuses on a key chemokine named CXCL10 and its role in directing the migratory propertied and biological function of CD4+ and CD8+ T cells in the context of cancer and inflammatory autoimmunity. CXCR3 is a chemokine receptor that is abundant on CD4+ T cells, CD8+ T cells and NK cells. It has three known ligands: CXCL9, CXCL10 and CXCL11...
February 12, 2018: Cytokine
https://www.readbyqxmd.com/read/29448870/a-new-assessment-tool-for-ulnar-drift-in-patients-with-rheumatoid-arthritis-using-pathophysiological-parameters-of-the-metacarpophalangeal-joint
#14
Shogo Toyama, Ryo Oda, Daisaku Tokunaga, Daigo Taniguchi, Satoru Nakamura, Maki Asada, Hiroyoshi Fujiwara, Toshikazu Kubo
OBJECTIVES: To establish a new assessment tool for ulnar drift (UD) in rheumatoid arthritis. METHODS: We established an observational cohort of 67 patients (134 rheumatoid hands) beginning in 2004. Fifty-two patients (100 hands) had follow-up in 2009, and thirty-seven patients (63 hands) completed follow-up in 2015. UD was evaluated with the Fearnley classification and our scoring method, which assesses four parameters of the metacarpophalangeal joint. Cluster analysis using UD parameters divided hands into groups...
February 15, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29447842/neutrophils-drive-type-i-interferon-production-and-autoantibodies-in-wiskott-aldrich-syndrome
#15
K E Cervantes-Luevano, N Caronni, M C Castiello, E Fontana, G Piperno, A Naseem, P Uva, M Bosticardo, G E Marcovecchio, L D Notarangelo, M P Cicalese, A Aiuti, A Villa, F Benvenuti
BACKGROUND: Wiskott-Aldrich syndrome (WAS) is a rare primary immunodeficiency caused by mutations in WASp, a key regulator of cytoskeletal dynamics in hematopoietic cells. A high proportion of patients develop autoimmunity due to a breakdown in T and B cell tolerance. Moreover, excessive production of type-I interferon by plasmacytoid DCs contribute to autoimmune signs, however, the factors that triggers excessive innate activation have not been defined. OBJECTIVE: Neutrophils extracellular traps (NETs) emerged as major initiating factors in diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)...
February 12, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29447542/predictors-for-orthopaedic-surgery-in-patients-with-rheumatoid-arthritis-results-from-a-retrospective-cohort-study-of-1010-patients-diagnosed-from-1972-to-2009-and-followed-up-until-2015
#16
T W Nystad, A M Fenstad, O Furnes, B T Fevang
OBJECTIVES: To investigate how patient characteristics, time of diagnosis, and treatment affect the need for orthopaedic surgery in patients with rheumatoid arthritis (RA). METHOD: We reviewed the medical history of 1544 patients diagnosed with RA at Haukeland University Hospital in Bergen, Norway, from 1972 to 2009, of whom 1010 (mean age 57 years, 69% women) were included in the present study. Relevant orthopaedic procedures were obtained from the Norwegian Arthoplasty Register and the hospital's administrative patient records...
February 15, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29447492/physiotherapists-management-of-challenging-situations-in-guiding-people-with-rheumatoid-arthritis-to-health-enhancing-physical-activity
#17
Thomas Nessen, Christina H Opava, Cathrin Martin, Ingrid Demmelmaier
OBJECTIVES: To explore strategies used by physiotherapists (PTs) in guiding people with rheumatoid arthritis to health-enhancing physical activity (HEPA) in a group setting during a 1-year intervention study. METHODS: Exploratory design with qualitative video analysis performed in three steps. Eleven female PTs were video recorded while leading support group sessions aiming at facilitating HEPA (twice-weekly exercise sessions at public gyms and 150 weekly minutes of moderately intense aerobic physical activity)...
February 15, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29447376/the-relationship-between-depression-and-biologic-treatment-response-in-rheumatoid-arthritis-an-analysis-of-the-british-society-for-rheumatology-biologics-register
#18
Faith Matcham, Rebecca Davies, Matthew Hotopf, Kimme L Hyrich, Sam Norton, Sophia Steer, James Galloway
Objective: To investigate the relationship between depressive symptoms and treatment response and disease activity in RA over a 1-year follow-up. Methods: Data from the British Society for Rheumatology Biologics Register were used, representing 18 421 RA patients receiving biologic treatment. Depressive symptoms were identified through one of three assessments: reporting a history of depression, the Medical Outcomes Survey 36-item Short Form or the EuroQol, five-dimension scale...
February 13, 2018: Rheumatology
https://www.readbyqxmd.com/read/29447310/retrospective-evaluation-of-factors-related-to-the-outcomes-of-regenerative-therapy-for-implants-affected-by-peri-implantitis
#19
Stuart J Froum, Paul S Rosen, Wendy Cw Wang, Scott H Froum, Shalin Vinayak
The aim of this retrospective study was to examine the histories of 100 patients with 170 implants that were consecutively treated and reported in a previous study to identify which patient and implant factors might have affected the outcomes of therapy. Patient factors included history of periodontitis, hypertension, cardiac problems, rheumatoid arthritis, smoking, and penicillin allergy. Implant factors included whether the prosthesis was cemented or screw retained and initial bone loss (≤ 50% or > 50% of implant length)...
March 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29447014/macrophage-migration-inhibitory-factor-mif-inhibitor-z-590-suppresses-cartilage-destruction-in-adjuvant-induced-arthritis-via-inhibition-of-macrophage-inflammatory-activation
#20
Zhiyu Zhang, Rong Zhang, Linlang Li, Lijun Zhu, Shiyuan Gao, Qiran Lu, Yihui Gu, Yu Zhang, Huicui Yang, Tingjun Hou, Xuechu Zhen, Long Tai Zheng
INTRODUCTION: Macrophage migration inhibitory factor (MIF) is a pleiotropic pro-inflammatory mediator that is involved in the progression of rheumatoid arthritis (RA). Previously, we demonstrated a small molecule compound 3-[(biphenyl-4-ylcarbonyl) carbamothioyl] amino benzoic acid (Z-590) could inhibit MIF activity with docking-based virtual screening and experimental evaluation. MATERIALS AND METHODS: The LPS activated RAW264.7 macrophage cells were used to determine the anti-inflammatory effects of Z-590 in vitro...
February 15, 2018: Immunopharmacology and Immunotoxicology
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