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https://www.readbyqxmd.com/read/29649405/economic-impact-of-early-inpatient-palliative-care-intervention-in-a-community-hospital-setting
#1
James Fitzpatrick, Matthew Mavissakalian, Tisha Luciani, Yijing Xu, Amber Mazurek
BACKGROUND: Inpatient palliative care programs have demonstrated financial benefit for the hospital and improved quality of care for patients with advanced disease. Previous studies on this subject have focused on comparisons between palliative and traditional care. The financial and clinical effects of early versus late palliative care intervention are less well documented. OBJECTIVE: The aims of this study are to review the financial and quality outcomes that early palliative care intervention has on appropriate inpatients in the community hospital setting...
March 20, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29629403/effectiveness-of-umeclidinium-vilanterol-for-protocolized-management-of-chronic-obstructive-pulmonary-disease-exacerbation-in-hospitalized-patients-a-sequential-period-analysis
#2
Todd W Chapin, Michael A Mann, Gary L Brown, Traci L Leitheiser, Becky Anderson, David D Leedahl
Background: Bronchodilator therapy is a foundation of chronic obstructive pulmonary disease (COPD) exacerbation treatment. Although international guidelines recommend short-acting formulations given multiple times per day, long-acting formulations have not been adequately evaluated. The objective of our study was to determine the effectiveness of umeclidinium-vilanterol (UME/VIL), long-acting beta2-agonist/long-acting muscarinic antagonist (LABA/LAMA) as a once-daily alternative for treating COPD exacerbations in hospitalized patients...
January 24, 2018: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://www.readbyqxmd.com/read/29628760/support-needs-of-patients-with-copd-a-systematic-literature-search-and-narrative-review
#3
REVIEW
A Carole Gardener, Gail Ewing, Isla Kuhn, Morag Farquhar
Introduction: Understanding the breadth of patients' support needs is important for the delivery of person-centered care, particularly in progressive long-term conditions such as chronic obstructive pulmonary disease (COPD). Existing reviews identify important aspects of managing life with COPD with which patients may need support (support needs); however, none of these comprehensively outlines the full range of support needs that patients can experience. We therefore sought to systematically determine the full range of support needs for patients with COPD to inform development of an evidence-based tool to enable person-centered care...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29609699/considerations-for-geriatric-patients-with-copd
#4
Nikki Neumann, Paige Odegard, Michael Swanoski
As patients age, they are predisposed to certain disease states such as chronic obstructive pulmonary disease (COPD). Physiologic changes that occur during aging as well as guidelines for treatment must be considered in providing pharmaceutical care for older adults. Preferred treatment options have special considerations in the aging population because of the inability to use certain inhaler devices and medications appropriately. This paper reviews physiologic changes in geriatric adults, COPD treatment, medications that should be avoided in this population, and special considerations for geriatric patients with COPD...
April 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29607148/ventilator-associated-events-after-cardiac-surgery-evidence-from-1-709-patients
#5
Siyi He, Fan Wu, Xiaochen Wu, Mei Xin, Sheng Ding, Jian Wang, Hui Ouyang, Jinbao Zhang
Background: Ventilator-associated event (VAE) is a new surveillance for nosocomial infections in mechanically ventilated patients. To date, little is known about VAEs after cardiac surgeries. The present study firstly focused on patients who have undergone heart operations, intending to draw a comprehensive description of VAEs. Methods: Postoperative patients from September 2012 to December 2015 were monitored for VAEs. By reviewing electronic medical records and preserved files retrospectively, clinical data were further analyzed...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29605653/-study-of-the-feasibility-of-spirometry-in-general-practice
#6
L Bunge, D Baruch, L Plantier, T Mazars, N Roche, A Izadifar
COPD is common but is under-diagnosed by general practitioners (GP). GP have a major role in the early diagnosis of this disease. GP could have access to spirometry. The aim of this study was to evaluate the quality and interpretation of spirometry performed by primary care residents following a short education session. Three residents were trained in spirometry for half a day. They then performed spirometry on all smokers over the age of 35 visiting five general practices. The results were reviewed blindly by an independent specialist pulmonologist to assess their quality and interpretation...
March 29, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29605192/rate-of-and-barriers-and-enablers-to-pulmonary-rehabilitation-referral-in-copd-a-systematic-scoping-review
#7
REVIEW
Siobhan C Milner, Jill T Boruff, Cecile Beaurepaire, Sara Ahmed, Tania Janaudis-Ferreira
BACKGROUND: Despite pulmonary rehabilitation (PR) being an evidence-based treatment recommended for people with chronic obstructive pulmonary disease (COPD), referral to PR seems to be low. Collating the evidence on referral rates and perceived barriers and enablers may help provide knowledge needed to increase referral. OBJECTIVES: The purpose of this scoping review was to determine 1) the rate of referral of patients with COPD to PR by healthcare professionals (HCPs) and 2) the barriers and enablers to referral perceived by HCPs...
April 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29605098/possible-involvement-of-acetylcholine-mediated-inflammation-in-airway-diseases
#8
REVIEW
Akira Koarai, Masakazu Ichinose
Inhaled bronchodilator treatment with a long acting muscarinic antagonist (LAMA) reduces symptoms and the risk of exacerbations in COPD and asthma. However, increasing evidence from cell culture and animal studies suggests that anti-muscarinic drugs could also possess anti-inflammatory effects. Recent studies have revealed that acetylcholine (ACh) can be synthesized and released from both neuronal and non-neuronal cells, and the released ACh can potentiate airway inflammation and remodeling in airway diseases...
March 28, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29602937/influence-of-risk-factors-on-development-of-chronic-obstructive-pulmonary-disease-and-legislative-foundations-for-copd-medical-care-in-ukraine
#9
Vasyl M Mykhalchuk, Averian G Vasyliev
OBJECTIVE: Introduction: Out of all respiratory diseases COPD is the leading cause of death and is characterized with diffuse non-reversible airway obstruction. Many various components play role in development and progression of this disease, while COPD risk factors play the most prominent role. Further progress in healthcare system development around COPD in Ukraine requires analysis of legislation, regulating pulmonological medical service in Ukraine. The aim: To analyze the influence of major risk factors on the development of chronic obstructive pulmonary disease and to determine key legislative aspects of the organization of medical care for COPD patients in Ukraine...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29599897/reactive-oxygen-species-in-chronic-obstructive-pulmonary-disease
#10
REVIEW
Samia Boukhenouna, Mark A Wilson, Karim Bahmed, Beata Kosmider
Chronic obstructive pulmonary disease (COPD) includes chronic bronchitis and emphysema. Environmental exposure, primarily cigarette smoking, can cause high oxidative stress and is the main factor of COPD development. Cigarette smoke also contributes to the imbalance of oxidant/antioxidant due to exogenous reactive oxygen species (ROS). Moreover, endogenously released ROS during the inflammatory process and mitochondrial dysfunction may contribute to this disease progression. ROS and reactive nitrogen species (RNS) can oxidize different biomolecules such as DNA, proteins, and lipids leading to epithelial cell injury and death...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29595991/the-clinical-effects-of-manipulative-therapy-in-people-with-chronic-obstructive-pulmonary-disease
#11
Jayde Galletti, George Mcheileh, Andrew Hahne, Annemarie Louise Lee
OBJECTIVES: This study aimed to determine the effects of manipulative therapies (MT), including spinal manipulation, and diaphragmatic release techniques on lung function, exercise capacity, symptoms, and health-related quality of life (HRQOL) in people with chronic obstructive pulmonary disease (COPD). DESIGN: Systematic review. PARTICIPANTS: People diagnosed with COPD. INTERVENTION: Randomized controlled trials of MT (either with or without pulmonary rehabilitation [PR]) compared to other treatments (soft tissue [ST] therapy or sham therapy) applied in people with COPD were identified following the search of seven databases...
March 29, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29592864/personalised-pulmonary-rehabilitation-in-copd
#12
Emiel F M Wouters, Birgit B R E F Wouters, Ingrid M L Augustin, Sarah Houben-Wilke, Lowie E G W Vanfleteren, Frits M E Franssen
This review summarises ongoing developments in personalised medicine and individualised medicine in chronic obstructive pulmonary disease (COPD). Currently applied classification systems largely ignore the complexity and heterogeneity of the COPD syndrome. Personalised medicine has to consider the influence of unique circumstances of the person, which contribute to this heterogeneity and complexity. Pulmonary rehabilitation is described as a comprehensive, individualised intervention based on thorough assessment of identifiable treatable traits...
March 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29588624/stereotactic-body-radiation-therapy-sbrt-in-the-management-of-non-small-cell-lung-cancer-clinical-impact-and-patient-perspectives
#13
REVIEW
Elysia K Donovan, Anand Swaminath
Stereotactic body radiation therapy (SBRT) has emerged as a new technology in radiotherapy delivery, allowing for potentially curative treatment in many patients previously felt not to be candidates for radical surgical resection of stage I non-small-cell lung cancer (NSCLC). Several studies have demonstrated very high local control rates using SBRT, and more recent data have suggested overall survival may approach that of surgery in operable patients. However, SBRT is not without unique toxicities, and the balance of toxicity, and effect on patient-reported quality of life need to be considered with respect to oncologic outcomes...
2018: Lung Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29587583/systematic-review-and-meta-analysis-of-unplanned-reoperations-emergency-department-visits-and-hospital-readmission-after-thyroidectomy
#14
Joseph Margolick, Wenjia Chen, Sam Wiseman
BACKGROUND: Unplanned reoperation, Emergency Department (ED) visits, and hospital readmission following thyroid operations usually arise due to complications, and are a source of frustration for both surgeons and patients. With an aim to provide insight important for the development of patient quality care improvement initiatives, the primary objective of this review was to systematically evaluate the available literature in order to determine the contemporary rates of reoperation, readmission and ED visits following thyroid operations...
March 27, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29583021/copd-2017-a-year-in-review
#15
Ernesto Crisafulli, Antoni Torres
In this review, we focused on original manuscripts published in the 2017 that provided additional information on the clinical and therapeutic features of the chronic obstructive pulmonary disease (COPD). We have chosen eight of these studies, collected in four topics concerning the pharmacological treatment (tiotropium) of mild-moderate patients, the pharmacological (fluticasone furoate/vilanterol/umeclidinium) and non-pharmacological treatment (non-invasive mechanical ventilation) of severe patients, the etiology of acute exacerbation of COPD involving seasonal airway pathogens and the role of eosinophils with particular interest to the monoclonal antibody directed against interleukin-5 (mepolizumab)...
March 27, 2018: COPD
https://www.readbyqxmd.com/read/29569912/free-radical-production-and-oxidative-stress-in-lung-tissue-of-patients-exposed-to-sulfur-mustard-an-overview-of-cellular-and-molecular-mechanisms
#16
Asghar Beigi Harchegani, Eisa Tahmasbpour, Hojat Borna, Ali Imamy, Mostafa Ghanei, Alireza Shahriary
Sulfur mustard (SM) is a chemical alkylating compound that primary targets lung tissue. It causes a wide variety of pathological effects in respiratory system such as chronic bronchitis, bronchiolitis obliterans, necrosis of the mucosa and inflammation, chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis. However, molecular and cellular mechanisms for these pathologies are still unclear. Oxidative stress (OS) induced by reactive oxygen species (ROS) is likely a significant mechanism by which SM leads to cell death and tissues injury...
March 23, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29559389/matrix-remodeling-in-chronic-lung-diseases
#17
REVIEW
Bon-Hee Gu, Matthew C Madison, David Corry, Farrah Kheradmand
Multicellular organisms synthesize and renew components of their subcellular and scaffolding proteins, collectively known as the extracellular matrix molecules (ECMs). In the lung, ECMs maintain tensile strength, elasticity, and dictate the specialized function of multiple cell lineages. These functions are critical in lung homeostatic processes including cellular migration and proliferation during morphogenesis or in response to repair. Alterations in lung ECMs that expose cells to new cryptic fragments, generated in response to endogenous proteinases or exogenous toxins, are associated with the development of several common respiratory diseases...
March 17, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29558787/exposure-to-nitrogen-dioxide-and-chronic-obstructive-pulmonary-disease-copd-in-adults-a-systematic-review-and-meta-analysis
#18
Zili Zhang, Jian Wang, Wenju Lu
Exposure to nitrogen dioxide (NO2 ) has long been linked to elevated mortality and morbidity from epidemiological evidences. However, questions remain unclear whether NO2 acts directly on human health or being an indicator of other ambient pollutants. In this study, random-effect meta-analyses were performed on examining exposure to nitrogen oxide (NOx ) and its association with chronic obstructive pulmonary disease (COPD). The overall relative risk (RR) of COPD risk related to a 10 μg/m3 increase in NO2 exposure increased by 2...
March 20, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29558200/magnetic-stimulation-therapy-in-patients-with-copd-a-systematic-review
#19
Massimiliano Polastri, Vittoria Comellini, Angela Maria Grazia Pacilli, Stefano Nava
Magnetotherapy (MT) is a therapeutic treatment based on the use of magnetic fields (MF) that can have an anti-inflammatory and analgesic effect. MT represents a possible treatment or an ancillary therapeutic intervention for a wide range of diseases and it is often used in the field of physiotherapeutic practices. A crucial point in the treatment of chronic obstructive pulmonary disease (COPD) patients, to counteract muscular depletion and respiratory symptoms, is represented by physiotherapy. Nevertheless, the knowledge about the application of MF as a therapeutic option in COPD patients is very limited...
March 20, 2018: COPD
https://www.readbyqxmd.com/read/29558165/current-approaches-for-phenotyping-as-a-target-for-precision-medicine-in-copd-management
#20
Jose Luis Lopez-Campos, Stefano Centanni
The study of airway diseases continues to present several challenges for modern medicine. The different disease presentations with variables and overlapping features may result in a real challenge for the clinician. In this context, the concept of precision medicine has started to emerge in order to give answers to some of these challenges from a diagnostic and therapeutic point of view. The main reasons to target for precision medicine in chronic obstructive pulmonary disease (COPD) include that there is variability in the clinical presentation, there is no correlation between the different clinical variables at the patient level, there are a number of relevant clinical variables associated with outcomes, we do have specific therapies for specific patient types, and that there is variability in the clinical response to different therapies...
March 20, 2018: COPD
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