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https://www.readbyqxmd.com/read/29161785/intraoperative-mri-for-resection-of-intracranial-meningiomas
#1
Shamik Chakraborty, Salvatore Zavarella, Sussan Salas, Michael Schulder
Objective: To examine whether intraoperative MRI can enhance safety and extent of resection of complex intracranial meningiomas, given its positive role in the resection of malignant brain tumors and pituitary tumors. Methods: Over a ten-year period, 70 operations were performed on 66 patients with intracranial meningiomas using the compact, mobile PoleStar N20 iMRI navigation system. A retrospective review was conducted examining patient demographics, surgical characteristics, and outcomes...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29161707/a-novel-animal-model-simulating-the-beginning-of-combat-exposure
#2
Dongsoo Kim, Chang Yul Kim, Hyojin Koo, Yong Heo, Kicheol Cheon
OBJECTIVE: Predator stress, social defeat stress, and fear conditioning animal models have been applied to investigate combat-related posttraumatic stress disorder (PTSD). However, no animal model psychopharmacological studies have investigated prevention of somatization of increased mental stress and fatigue at the beginning of combat exposure. This study utilized a novel animal model simulating the beginning of combat exposure that aided specification of a set of biomarkers. METHODS: Psychological stress was induced by both inescapable electric foot shock and noise stimuli...
November 22, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29161636/infant-hpa-axis-as-a-potential-mechanism-linking-maternal-mental-health-and-infant-telomere-length
#3
Benjamin W Nelson, Nicholas B Allen, Heidemarie Laurent
Maternal depression has been suggested to be an independent risk factor for both dysregulated hypothalamic-pituitary-adrenal axis (HPA) functioning and shorter telomere length in offspring. In contrast, research suggests that individual differences in mindfulness may act as a protective factor against one's own telomere degradation. Currently, research has yet to investigate the association between longitudinal changes in maternal mental health (depressive symptoms and mindfulness) and salivary infant telomere length, and whether such changes might be mediated by alterations in infant cortisol response...
November 18, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29159066/six-adult-patients-with-septo-optic-dysplasia-and-drug-resistant-epilepsy-clinical-findings-and-course
#4
Mashael AlKhateeb, Richard McLachlan, Jorge Burneo, David Diosy, Seyed Mirsattari
Septo-optic dysplasia (SOD) is a rare disorder associated with optic nerve hypoplasia, pituitary abnormalities and agenesis/dysgenesis of midline brain structures including the septum pellucidum and corpus callosum. Though sometimes associated with drug-resistant epilepsy, this association has not been well studied. We report six SOD patients with associated malformation of cortical development (MCD) and drug-resistant epilepsy who underwent video-EEG telemetry at our centre between 1998 and 2016 for drug-resistant epilepsy...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/29158903/severe-cushing-s-syndrome-and-bilateral-pulmonary-nodules-beyond-ectopic-acth
#5
Carlos Tavares Bello, Emma van der Poest Clement, Richard Feelders
Cushing's syndrome is a rare disease that results from prolonged exposure to supraphysiological levels of glucocorticoids. Severe and rapidly progressive cases are often, but not exclusively, attributable to ectopic ACTH secretion. Extreme hypercortisolism usually has florid metabolic consequences and is associated with an increased infectious and thrombotic risk. The authors report on a case of a 51-year-old male that presented with severe Cushing's syndrome secondary to an ACTH-secreting pituitary macroadenoma, whose diagnostic workup was affected by concurrent subclinical multifocal pulmonary infectious nodules...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29158902/hypernatraemic-hypovolaemia-with-anaemia-an-unusual-presentation-of-primary-testicular-insufficiency
#6
Usman Javaid, Vikram Lal, Catherine Napier, Alison Burbridge, Richard Quinton
Hypogonadal men may experience intense vasomotor symptoms, and vasomotor sweating can occasionally be associated with profound fluid losses. We describe a 37-year-old male, who exhibited persistent hypovolaemic hypernatraemia that was challenging to treat despite a continuous high fluid input (>4-5 L/day). He was noted to have drenching sweats and normochromic anaemia. He had recent traumatic head injury, which resulted in neurocognitive dysfunction, so pituitary function tests were done which showed primary hypogonadism...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29158862/-epidermoid-cyst-in-the-sella-turcica-about-a-case
#7
Ghizlane El Mghari, Bouchra Rafiq, Nawal El Ansari
Epidermoid cyst (EC) or cholesteatoma is a benign tumor, often of congenital origin, occurring in the sub-arachnoidian spaces. Its treatment is based on surgery. We report the case of a 38 year-old patient presenting with progressive intracranial hypertension syndrome associated with anterior pituitary insufficiency signs of the corticotropic, thyrotropic, gonadotropic axis occurring 1 year before. Brain MRI showed a craniopharyngioma. Anatomopathologic evaluation of the specimen showed epidermoid cyst.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29158570/expression-of-sry-related-hmg-box-transcription-factors-sox-2-and-9-in-craniopharyngioma-subtypes-and-surrounding-brain-tissue
#8
Vivian Thimsen, Nora John, Michael Buchfelder, Jörg Flitsch, Rudolf Fahlbusch, Harald Stefanits, Engelbert Knosp, Marco Losa, Rolf Buslei, Annett Hölsken
Stem cells have been discovered as key players in the genesis of different neoplasms including craniopharyngioma (CP), a rare tumour entity in the sellar region. Sox2 and Sox9 are well-known stem cell markers involved in pituitary development. In this study we analysed the expression of both transcription factors using immunohistochemistry in a large cohort of 64 adamantinomatous (aCP) and 9 papillary CP (pCP) and quantitative PCR in 26 aCP and 7 pCP. Whereas immunohistochemically Sox2+ cells were verifiable in only five aCP (7...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29158391/maternal-prolactin-during-late-pregnancy-is-important-in-generating-nurturing-behavior-in-the-offspring
#9
Taku James Sairenji, Jun Ikezawa, Ryosuke Kaneko, Shinnosuke Masuda, Kaoru Uchida, Yurie Takanashi, Hiroko Masuda, Tomoko Sairenji, Izuki Amano, Yusuke Takatsuru, Kazutoshi Sayama, Kaisa Haglund, Ivan Dikic, Noriyuki Koibuchi, Noriaki Shimokawa
Although maternal nurturing behavior is extremely important for the preservation of a species, our knowledge of the biological underpinnings of these behaviors is insufficient. Here we show that the degree of a mother's nurturing behavior is regulated by factors present during her own fetal development. We found that Cin85-deficient (Cin85(-/-)) mother mice had reduced pituitary hormone prolactin (PRL) secretion as a result of excessive dopamine signaling in the brain. Their offspring matured normally and produced their own pups; however, nurturing behaviors such as pup retrieval and nursing were strongly inhibited...
November 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29158096/cost-effectiveness-of-endoscopic-versus-microscopic-transsphenoidal-surgery-for-pituitary-adenoma
#10
Jared D Ament, Zhuo Yang, Vic Khatchadourian, Bradley Strong, Kiarash Shahlaie
No abstract text is available yet for this article.
November 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29157995/in-the-ovine-pituitary-cxcr4-is-localized-in-gonadotropes-and-somatotropes-and-increases-with-elevated-serum-progesterone
#11
N S Sanchez, K E Quinn, A K Ashley, R L Ashley
The pituitary is the central endocrine regulator of reproduction and in addition to various hormones regulating its actions, other molecules, such as chemokines, influence pituitary physiology as well. Despite reports over 2 decades ago that chemokines regulate the pituitary, much of the basic biology discerning chemokine action in the pituitary is unclear. A small number of chemokines and their receptors have been localized to the pituitary, yet chemokine ligand 12 (CXCL12) and its receptor, CXCR4, have received the most attention as both are increased in human pituitary adenomas...
October 28, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/29157942/expression-of-two-glycoprotein-hormone-receptors-in-larval-parasitic-phase-and-adult-sea-lampreys
#12
Krist N Hausken, Timothy J Marquis, Stacia A Sower
All jawed vertebrates have three canonical glycoprotein hormones (GpHs: luteinizing hormone, LH; follicle stimulating hormone, FSH; and thyroid stimulating hormone, TSH) with three corresponding GpH receptors (GpH-Rs: LH-R, FSH-R and TSH-R). In contrast, we propose that the jawless vertebrate, sea lamprey (Petromyzon marinus), only has two pituitary glycoprotein hormones, lamprey (l)GpH and l-thyrostimulin, and two functional glycoprotein receptors, lGpH-R I and II. It is not known at this time whether there is a specific receptor for lGpH and l-thyrostimulin, or if both GpHs can differentially activate the lGpH-Rs...
November 17, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29157488/l%C3%A2-hypophyse-et-ses-traitements-comment-peuvent-ils-influer-sur-le-comportement-the-pituitary-and-its-treatments-how-can-they-influence-behaviour
#13
C Mouly, F Borson-Chazot, P Caron
Behaviour may be influenced by pituitary hormones or treatments. Dopamine agonist (DA) indicated in prolactinomas treatment can cause side effects, and especially impulse control disorders. In the context of prolactinomas treatment, impulse control disorders (ICD) have been reported like gambling, compulsive shopping, but mostly hypersexuality. These ICD can occur with low AD doses, and seem to be independent of type of molecule and psychiatric medical history. The main pathophysiologic hypothesis is a dysregulation of dopaminergic pathway involved in reward system...
October 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29157111/hmga2-cooperates-with-either-p27-kip1-deficiency-or-cdk4-r24c-mutation-in-pituitary-tumorigenesis
#14
Monica Fedele, Orlando Paciello, Davide De Biase, Mario Monaco, Gennaro Chiappetta, Michela Vitiello, Antonio Barbieri, Domenica Rea, Antonio Luciano, Serenella Papparella, Claudio Arra, Alfredo Fusco
We have previously reported a critical role of HMGA proteins in pituitary tumorigenesis since either the Hmga1 or Hmga2 gene overexpression/activation induces the development of mixed growth hormone/prolactin cell pituitary adenomas by activating the E2F transcription factor 1, and then enhancing the G1/S transition of the cell cycle. Consistently, amplification and overexpression of the HMGA2 gene was found in human pituitary prolactinomas. Since impairment of the cell cycle control represents a feature of experimental and human pituitary adenomas, we have investigated the possible synergism between the alterations of other cell cycle regulators, such as p27 deficiency or Cdk4(R24C) mutation, with Hmga2 overexpression in pituitary tumorigenesis...
November 20, 2017: Cell Cycle
https://www.readbyqxmd.com/read/29156706/mkrn3-functions-as-a-novel-ubiquitin-e3-ligase-to-inhibit-nptx1-during-puberty-initiation
#15
Huifang Liu, Xiangxin Kong, Fengling Chen
Central precocious puberty (CPP) is attributed to the disorder of some trigger factors those can activate the hypothalamic-pituitary-gonadal axis controlled by GnRH neurons. Many recent studies reveal one of those trigger factors, Makorin ring finger protein 3 (Mkrn3), whose loss-of-function mutations are implicated in CPP. Although Mkrn3 contained zinc Ring finger domain is considered as a putative E3 ubiquitin ligase, its actual function is never reported. Here, our results demonstrated that in mice hypothalamus before and when puberty initiated, Mkrn3 expressed the reversed tendency with Nptx1, which is an important secreted protein for neuron development...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29155897/advances-in-applied-homeostatic-modelling-of-the-relationship-between-thyrotropin-and-free-thyroxine
#16
Rudolf Hoermann, John Edward Maurice Midgley, Rolf Larisch, Johannes Wolfgang Christian Dietrich
INTRODUCTION: The relationship between pituitary TSH and thyroid hormones is central to our understanding of thyroid physiology and thyroid function testing. Here, we generated distribution patterns by using validated tools of thyroid modelling. METHODS: We simulated patterns of individual set points under various conditions, based on a homeostatic model of thyroid feedback control. These were compared with observed data points derived from clinical trials. RESULTS: A random mix of individual set points was reconstructed by simulative modelling with defined structural parameters...
2017: PloS One
https://www.readbyqxmd.com/read/29155851/pac1-and-vpac2-receptors-in-light-regulated-behavior-and-physiology-studies-in-single-and-double-mutant-mice
#17
Jens Hannibal, Birgitte Georg, Jan Fahrenkrug
The two sister peptides, pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) and their receptors, the PAC1 -and the VPAC2 receptors, are involved in regulation of the circadian timing system. PACAP as a neurotransmitter in the retinohypothalamic tract (RHT) and VIP as a neurotransmitter, involved in synchronization of SCN neurons. Behavior and physiology in VPAC2 deficient mice are strongly regulated by light most likely as a result of masking. Consequently, we used VPAC2 and PAC1/VPAC2 double mutant mice in comparison with PAC1 receptor deficient mice to further elucidate the role of PACAP in the light mediated regulation of behavior and physiology of the circadian system...
2017: PloS One
https://www.readbyqxmd.com/read/29155347/postoperative-gamma-knife-radiosurgery-for-cavernous-sinus-invading-growth-hormone-secreting-pituitary-adenomas
#18
Eui Hyun Kim, Min Chul Oh, Jong Hee Chang, Ju Hyung Moon, Cheol Ryong Ku, Won-Seok Chang, Eun Jig Lee, Sun Ho Kim
OBJECTIVE: We aimed to determine the long-term effects of Gamma knife radiosurgery (GKS) on remnants in the cavernous sinus (CS) after transsphenoidal surgery (TSS) for acromegaly and to identify its possible adverse effects. METHODS: Thirty patients who had remnant tumors only inside the CS after TSS and who consequently underwent GKS were included. They were followed for a median period of 47 months after GKS with regular hormonal and radiological examinations...
November 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29155267/chronic-subcutaneous-infusion-of-neurosecretory-protein-gm-increases-body-mass-gain-in-chicks
#19
Kenshiro Shikano, Shusuke Taniuchi, Eiko Iwakoshi-Ukena, Megumi Furumitsu, George E Bentley, Lance J Kriegsfeld, Kazuyoshi Ukena
Recently we discovered a small hypothalamic protein in the chicken, named neurosecretory protein GL (NPGL), which is associated with body growth and energy metabolism in birds and rodents. Genome database analysis suggested that the NPGL gene has a paralogous gene in vertebrates, named neurosecretory protein GM (NPGM). However, the biological action of NPGM remains unclear. In this study, we investigated whether NPGM affects body growth in chicks. We found that subcutaneous infusion of NPGM for six days increased body mass gain in a dose-dependent manner...
November 16, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29155247/cells-have-sex-chromosomes-and-circadian-clocks-implications-for-organismal-level-functions
#20
Rae Silver
A great number of stakeholders have a keen interest in issues surrounding sex differences. These participants in the discourse often use the same evidence to draw opposite conclusions, with implications for individuals and society as a whole. One part of the maelstrom and associated emotionality derives from confounds between the concepts of "sex" vs. "gender", even among professionals. Here, the oft-repeated point is made that evidence for gender differences can't be derived from the animal research, once the generally accepted conception of gender as a process unique to humans, is acknowledged...
November 15, 2017: Physiology & Behavior
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