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https://www.readbyqxmd.com/read/29111077/international-randomized-controlled-trial-of-transcranial-direct-current-stimulation-in-depression
#1
Colleen K Loo, Mustafa M Husain, William M McDonald, Scott Aaronson, John P O'Reardon, Angelo Alonzo, Cynthia Shannon Weickert, Donel M Martin, Shawn M McClintock, Adith Mohan, Sarah H Lisanby
BACKGROUND: Evidence suggests that transcranial Direct Current Stimulation (tDCS) has antidepressant effects in unipolar depression, but there is limited information for patients with bipolar depression. Additionally, prior research suggests that brain derived neurotrophic factor (BDNF) Val66Met genotype may moderate response to tDCS. OBJECTIVE: To examine tDCS efficacy in unipolar and bipolar depression and assess if BDNF genotype is associated with antidepressant response to tDCS...
October 27, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29098314/acute-and-repetitive-fronto-cerebellar-tdcs-stimulation-improves-mood-in-non-depressed-participants
#2
Simon Newstead, Hayley Young, David Benton, Gabriela Jiga-Boy, Maria L Andrade Sienz, R M Clement, Frédéric Boy
Transcranial direct current stimulation (tDCS) is a non-invasive form of brain stimulation, which allows for selective inhibition or excitation of neural structures. It has demonstrated some efficacy in the treatment of mood disorders. However, these studies have predominately focused on stimulation of the prefrontal cortex (PFC). The cerebellum has an increasingly recognized role in emotional control, affective state, and some psychopathologies. As such, tDCS research into mood modulation needs to expand beyond conventional PFC-focused paradigms...
November 2, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29079367/astrocytes-as-a-target-of-transcranial-direct-current-stimulation-tdcs-to-treat-depression
#3
REVIEW
Hiromu Monai, Hajime Hirase
Transcranial direct current stimulation (tDCS) has been reported to be effective in treating mood disorders such as major depressive disorder, however, its detailed mechanism of action is not fully understood. Human and animal experiments have demonstrated that tDCS promotes brain plasticity and have suggested that this consequence may underlie its therapeutic benefits. Nonetheless, the specific neurobiological underpinnings of tDCS-induced brain plasticity have only recently begun to be investigated. While brain plasticity occurs in synapses formed by neurons, astrocytes, a major glial cell type, have recently been shown to support synaptic plasticity via intracellular Ca(2+) signaling...
October 25, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29077142/-non-invasive-neurostimulation-in-the-treatment-of-child-and-adolescent-psychiatry
#4
S van der Meersche, G Lemmens, C Matton, C Baeken
Neurostimulation is a potentially interesting treatment option for children and adolescents with psychiatric disorders.<br/> AIM: To review the efficacy of two non-invasive neurostimulation techniques, namely repetitive transcranial magnetic stimulation (rtms) and transcranial direct current stimulation (tdcs), in the treatment of child and adolescent psychiatric disorders.<br/> METHOD: We searched the literature research using PubMed.<br/> RESULTS: There is some evidence that rtms is being used to treat unipolar depression, psychosis, autism spectrum disorder, attention deficit hyperactivity disorder and tic disorder...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/29077134/-minimally-invasive-brain-stimulation-for-unipolar-depression
#5
P van Eijndhoven, I Tendolkar, P van Eijndhoven, I Tendolkar, D J L G Schutter
BACKGROUND: Unipolar depression is one of the most prevalent psychiatric disorders and has a high impact at individual and societal level. Commonly used treatments such as antidepressants and psychotherapy are often not effective. AIM: To determine the efficacy of repetitive transcranial magnetic stimulation (rTMS) and direct current stimulation (tDCS) as minimally invasive forms of treatment for unipolar depression. METHOD: We searched the literature...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/29066167/the-effects-of-medication-use-in-transcranial-direct-current-stimulation-a-brief-review
#6
REVIEW
Molly E McLaren, Nicole R Nissim, Adam J Woods
BACKGROUND: There has been increased interest in the potential use of transcranial direct current stimulation (tDCS) as treatment for multiple conditions including depression, pain, and cognitive impairment. However, few studies account for the possible influence of comorbid medications when conducting tDCS research. OBJECTIVE/HYPOTHESIS: This literature review was conducted to examine what is currently known about the impact of medications on tDCS, provide recommendations for future research practices, and highlight areas where more research is needed...
October 12, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29033856/possible-facilitative-effects-of-repeated-anodal-transcranial-direct-current-stimulation-on-functional-outcome-1-month-later-in-schizophrenia-an-open-trial
#7
Zui Narita, Takuma Inagawa, Kazuki Sueyoshi, Crystal Lin, Tomiki Sumiyoshi
Recent research on neuromodulation techniques, such as transcranial direct current stimulation (tDCS), for the treatment of schizophrenia has mainly focused on psychotic symptoms. We aimed to determine whether repetitive tDCS is efficacious in improving determinants of outcome, such as cognitive function, daily living skills, and depressive mood in patients with schizophrenia. Twenty-eight patients underwent tDCS (2 mA × 20 min) two times per day for 5 consecutive days. The anodal electrode was placed over the left dorsolateral prefrontal cortex while the cathodal electrode was placed over the right supraorbital region...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29018896/hypericum-perforatum-extract-modulates-cortical-plasticity-in-humans
#8
Carmen Concerto, Hyunji Boo, Charles Hu, Priam Sandilya, Anita Krish, Eileen Chusid, Diego Coira, Eugenio Aguglia, Fortunato Battaglia
BACKGROUND: Hypericum perforatum (HYP) extract is one of the most commonly used complementary alternative medicines (CAMs) for the treatment of mild-to-moderate depression. Non-invasive brain stimulation protocols can be used to investigate the effect of psychoactive substances on the human brain. In this study, we explored the effect of a single dose of HYP extract (WS 5570) intake on corticospinal excitability and plasticity in humans. METHODS: Twenty-eight healthy subjects were required to intake 900 mg of either HYP extract or placebo...
October 10, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28984619/the-therapeutic-use-of-non-invasive-brain-stimulation-in-multiple-sclerosis-a-review
#9
Rosa Iodice, Fiore Manganelli, Raffaele Dubbioso
BACKGROUND: Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system and a leading cause of disability in young adults. Many disabling symptoms in MS, such as spasticity, pain, depression and cognitive deficits are not fully controlled by drug treatment. Non-invasive brain stimulation (NIBS) techniques can be used as tools for modulating altered cortical excitability and plasticity MS patients, providing an improvement in disabling symptoms affecting such patients...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28971121/dataset-of-acute-repeated-sessions-of-bifrontal-transcranial-direct-current-stimulation-for-treatment-of-intractable-tinnitus-a-randomized-controlled-trial
#10
Ali Yadollahpour, Arash Bayat, Samaneh Rashidi, Nader Saki, Majid Karimi
Transcranial direct current stimulation (tDCS) has reportedly shown promising therapeutic effects for tinnitus (Forogh et al., 2016; Joos et al., 2014) [1], [2]. Studies are ongoing to determine optimum treatment protocol and the site of stimulation. Findings of the early studies are heterogeneous and most studies have focused on single session tDCS and short follow-up periods. There is no study on repeated sessions of tDCS with long term follow-up. This study presents the results of a randomized clinical trial investigating the therapeutic effects of acute multi-session tDCS over dorsolateral prefrontal cortex (DLPFC) on tinnitus symptoms and comorbid depression and anxiety in patients with chronic intractable tinnitus...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/28877142/adding-prefrontal-transcranial-direct-current-stimulation-before-occipital-nerve-stimulation-in-fibromyalgia
#11
Hye Bin Yoo, Jan Ost, Wim Joos, Tony Van Havenbergh, Dirk De Ridder, Sven Vanneste
OBJECTIVES: Fibromyalgia is a type of chronic musculoskeletal pain without a clear peripheral origin of nociception, often associated with depression. The underlying pathophysiology involves changes in a functional network that is related to pain and emotional processing in the central nervous system. Transcranial direct current stimulation (tDCS) targeting the dorsolateral prefrontal cortex or the occipital nerve (ON) are non-invasive neuromodulation techniques capable of improving fibromyalgia symptoms...
September 1, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28874923/noninvasive-brain-stimulation-maladaptive-plasticity-and-bayesian-analysis-in-phantom-limb-pain
#12
REVIEW
Leon Morales-Quezada
Introduction: Phantom limb pain (PLP) is a common and poorly understood pathology of difficult medical control that progressively takes place after amputation occurs. Objective: This article discusses the multifactorial bases of PLP. These bases involve local changes at the stump level, spinal modifications of excitability, deafferentation, and central sensitization, leading to the development of maladaptive plasticity, and consequentially, defective processing of sensory information by associative neural networks...
August 1, 2017: Medical Acupuncture
https://www.readbyqxmd.com/read/28805565/noninvasive-brain-stimulation-and-implications-for-nonmotor-symptoms-in-parkinson-s-disease
#13
Irena Rektorová, Ľubomíra Anderková
Transcranial noninvasive brain stimulation includes both repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS). TMS uses a rapidly changing magnetic field to induce currents and action potentials in underlying brain tissue, whereas tDCS involves the application of weak electrical currents to modulate neuronal membrane potential. In this chapter, we provide a literature review with a focus on the therapeutic potential of both techniques in the treatment of nonmotor symptoms of Parkinson's disease (PD)...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28709880/low-intensity-transcranial-electric-stimulation-safety-ethical-legal-regulatory-and-application-guidelines
#14
REVIEW
A Antal, I Alekseichuk, M Bikson, J Brockmöller, A R Brunoni, R Chen, L G Cohen, G Dowthwaite, J Ellrich, A Flöel, F Fregni, M S George, R Hamilton, J Haueisen, C S Herrmann, F C Hummel, J P Lefaucheur, D Liebetanz, C K Loo, C D McCaig, C Miniussi, P C Miranda, V Moliadze, M A Nitsche, R Nowak, F Padberg, A Pascual-Leone, W Poppendieck, A Priori, S Rossi, P M Rossini, J Rothwell, M A Rueger, G Ruffini, K Schellhorn, H R Siebner, Y Ugawa, A Wexler, U Ziemann, M Hallett, W Paulus
Low intensity transcranial electrical stimulation (TES) in humans, encompassing transcranial direct current (tDCS), transcutaneous spinal Direct Current Stimulation (tsDCS), transcranial alternating current (tACS), and transcranial random noise (tRNS) stimulation or their combinations, appears to be safe. No serious adverse events (SAEs) have been reported so far in over 18,000 sessions administered to healthy subjects, neurological and psychiatric patients, as summarized here. Moderate adverse events (AEs), as defined by the necessity to intervene, are rare, and include skin burns with tDCS due to suboptimal electrode-skin contact...
September 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28684258/effects-of-transcranial-direct-current-stimulation-on-pain-mood-and-serum-endorphin-level-in-the-treatment-of-fibromyalgia-a-double-blinded-randomized-clinical-trial
#15
Eman M Khedr, Eman A H Omran, Nadia M Ismail, Dina H El-Hammady, Samar H Goma, Hassan Kotb, Hannan Galal, Ayman M Osman, Hannan S M Farghaly, Ahmed A Karim, Gehad A Ahmed
BACKGROUND: Recent studies have shown that novel neuro-modulating techniques can have pain-relieving effects in the treatment of chronic pain. The aim of this work is to evaluate the effects of transcranial direct current stimulation (tDCS) in relieving fibromyalgia pain and its relation with beta-endorphin changes. MATERIAL AND METHODS: Forty eligible patients with primary fibromyalgia were randomized to receive real anodal tDCS or sham tDCS of the left motor cortex (M1) daily for 10 days...
June 23, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28681715/motor-cortex-trns-improves-pain-affective-and-cognitive-impairment-in-patients-with-fibromyalgia-preliminary-results-of-a-randomised-sham-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Massimiliano Curatolo, Giuseppe La Bianca, Giuseppe Cosentino, Roberta Baschi, Giuseppe Salemi, Rossella Talotta, Marcello Romano, Giovanni Triolo, Marina De Tommaso, Brigida Fierro, Filippo Brighina
OBJECTIVES: Fibromyalgia (FM) is a clinical syndrome characterised by widespread musculoskeletal pain, chronic fatigue, cognitive deficits, and sleep and mood disorders. The effectiveness of most pharmacological treatments is limited, and there is a need for new, effective and well-tolerated therapies. It has recently been shown that transcranial direct-current stimulation (tDCS) of the motor cortex reduces pain, and that tDCS of the dorso-lateral prefrontal cortex (DLPFC) improves anxiety, depression and cognitive impairment in FM patients...
May 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28681660/strategies-for-replacing-non-invasive-brain-stimulation-sessions-recommendations-for-designing-neurostimulation-clinical-trials
#17
Aurore Thibaut, Anthony Terrence O'Brien, Felipe Fregni
Despite the potential impact of missed visits on the outcomes of neuromodulation treatments, it is not clear how this issue has been addressed in clinical trials. Given this gap in the literature, we reviewed articles on non-invasive brain stimulation in participants with depression or chronic pain, and investigated how missed visits were handled. Areas covered: We performed a search on PUBMED/MEDLINE using the keywords: 'tDCS', 'transcranial direct current stimulation', 'transcranial magnetic stimulation', 'depression', and 'pain'...
August 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28657871/trial-of-electrical-direct-current-therapy-versus-escitalopram-for-depression
#18
RANDOMIZED CONTROLLED TRIAL
Andre R Brunoni, Adriano H Moffa, Bernardo Sampaio-Junior, Lucas Borrione, Marina L Moreno, Raquel A Fernandes, Beatriz P Veronezi, Barbara S Nogueira, Luana V M Aparicio, Lais B Razza, Renan Chamorro, Luara C Tort, Renerio Fraguas, Paulo A Lotufo, Wagner F Gattaz, Felipe Fregni, Isabela M Benseñor
BACKGROUND: We compared transcranial direct-current stimulation (tDCS) with a selective serotonin-reuptake inhibitor for the treatment of depression. METHODS: In a single-center, double-blind, noninferiority trial involving adults with unipolar depression, we randomly assigned patients to receive tDCS plus oral placebo, sham tDCS plus escitalopram, or sham tDCS plus oral placebo. The tDCS was administered in 30-minute, 2-mA prefrontal stimulation sessions for 15 consecutive weekdays, followed by 7 weekly treatments...
June 29, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28640159/transcranial-direct-current-stimulation-effects-on-menopausal-vasomotor-symptoms
#19
Mônia Steigleder Bianchi, Charles Francisco Ferreira, Felipe Fregni, Pedro Schestatsky, Wolnei Caumo, Maria Celeste Osório Wender
OBJECTIVE: To assess the effects of transcranial direct current stimulation (tDCS) compared with tDCS-sham on vasomotor symptoms of postmenopausal women. METHODS: Postmenopausal women (N = 30), aged between 45 and 68 years, with at least four episodes of vasomotor symptoms per day, were recruited from a specialized outpatient clinic at a tertiary hospital in the south of Brazil and through a media call after inclusion and exclusion criteria were ensured. Active and tDCS-sham were administered over the motor cortex position (anode electrode) and contralateral supraorbital region (cathode electrode) for 10 consecutive days, except weekends...
October 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28638351/transcranial-direct-current-stimulation-considerations-for-research-in-adolescent-depression
#20
REVIEW
Jonathan C Lee, Charles P Lewis, Zafiris J Daskalakis, Paul E Croarkin
Adolescent depression is a prevalent disorder with substantial morbidity and mortality. Current treatment interventions do not target relevant pathophysiology and are frequently ineffective, thereby leading to a substantial burden for individuals, families, and society. During adolescence, the prefrontal cortex undergoes extensive structural and functional changes. Recent work suggests that frontolimbic development in depressed adolescents is delayed or aberrant. The judicious application of non-invasive brain stimulation techniques to the prefrontal cortex may present a promising opportunity for durable interventions in adolescent depression...
2017: Frontiers in Psychiatry
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