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https://www.readbyqxmd.com/read/29787476/maternal-physical-activity-and-sex-impact-markers-of-hepatic-mitochondrial-health
#1
Rory P Cunningham, Mary P Moore, Grace M Meers, Gregory N Ruegsegger, Frank W Booth, R Scott Rector
INTRODUCTION: Maternal exercise and physical activity during the gestational period can be protective against maternal high fat diet-induced hepatic steatosis in older offspring. However, it is unknown whether these protective effects are seen in younger offspring. Here we investigated whether maternal physical activity would attenuate maternal western diet (WD)-induced steatosis in young adult rats. METHODS: Female Wistar rats (7-8 weeks of age) were randomized into WD (42% fat, 27% sucrose) or normal chow diet (ND), and further randomized into physical activity (RUN) or sedentary (SED) conditions for a total of four groups...
May 22, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29769745/corrigendum-small-molecule-mediated-up-regulation-of-microrna-targeting-a-key-cell-death-modulator-bnip3-improves-cardiac-function-following-ischemic-injury
#2
Se-Yeon Lee, Seahyoung Lee, Eunhyun Choi, Onju Ham, Chang Youn Lee, Jiyun Lee, Hyang-Hee Seo, Min-Ji Cha, Bohyun Mun, Yunmi Lee, Cheesoon Yoon, Ki-Chul Hwang
This corrects the article DOI: 10.1038/srep23472.
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29751091/sestrins-are-differentially-expressed-with-age-in-the-skeletal-muscle-of-men-a-cross-sectional-analysis
#3
Nina Zeng, Randall F D'Souza, Cameron J Mitchell, David Cameron-Smith
A gradual loss of skeletal muscle mass is a common feature of aging, leading to impaired insulin sensitivity and mobility. Sestrin1, 2, 3 are multifunctional proteins that regulate the mammalian target of rapamycin complex (mTORC1), autophagy and redox homeostasis. It is unclear how aging affects Sestrins and their downstream targets in human, therefore this study examined the basal expression of Sestrins in three age groups, young, middle-aged and older men and explored the mTORC1 pathway, autophagy markers and antioxidant regulation...
May 8, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29723988/dietary-%C3%AE-mangostin-provides-protective-effects-against-acetaminophen-induced-hepatotoxicity-in-mice-via-akt-mtor-mediated-inhibition-of-autophagy-and-apoptosis
#4
Xiao-Tong Yan, Yin-Shi Sun, Shen Ren, Li-Chun Zhao, Wen-Cong Liu, Chen Chen, Zi Wang, Wei Li
Acetaminophen overdose-induced hepatotoxicity is the most common cause of acute liver failure in many countries. Previously, alpha-mangostin (α-MG) has been confirmed to exert protective effects on a variety of liver injuries, but the protective effect on acetaminophen-induced acute liver injury (ALI) remains largely unknown. This work investigated the regulatory effect and underlying cellular mechanisms of α-MG action to attenuate acetaminophen-induced hepatotoxicity in mice. The increased serum aminotransferase levels and glutathione (GSH) content and reduced malondialdehyde (MDA) demonstrated the protective effect of α-MG against acetaminophen-induced hepatotoxicity...
May 1, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29707136/bnip3-modulates-the-interface-between-b16-f10-melanoma-cells-and-immune-cells
#5
Erminia Romano, Nicole Rufo, Hannelie Korf, Chantal Mathieu, Abhishek D Garg, Patrizia Agostinis
The hypoxia responsive protein BNIP3, plays an important role in promoting cell death and/or autophagy, ultimately resulting in a cancer type-dependent, tumour-enhancer or tumour-suppressor activity. We previously reported that in melanoma cells, BNIP3 regulates cellular morphology, mitochondrial clearance, cellular viability and maintains protein expression of CD47, a pro-cancerous, immunosuppressive 'don't eat me' signal. Surface exposed CD47 is often up-regulated by cancer cells to avoid clearance by phagocytes and to suppress immunogenic cell death (ICD) elicited by anticancer therapies...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29701696/estrogen-and-or-estrogen-receptor-%C3%AE-inhibits-bnip3-induced-apoptosis-and-autophagy-in-h9c2-cardiomyoblast-cells
#6
Bih-Cheng Chen, Yi-Jiun Weng, Marthandam Asokan Shibu, Chien-Kuo Han, Yueh-Sheng Chen, Chia-Yao Shen, Yueh-Min Lin, Vijaya Padma Viswanadha, Hsin-Yueh Liang, Chih-Yang Huang
The process of autophagy in heart cells maintains homeostasis during cellular stress such as hypoxia by removing aggregated proteins and damaged organelles and thereby protects the heart during the times of starvation and ischemia. However, autophagy can lead to substantial cell death under certain circumstances. BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3), a hypoxia-induced marker, has been shown to induce both autophagy and apoptosis. A BNIP3-docked organelle, e.g., mitochondria, also determines whether autophagy or apoptosis will take place...
April 26, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29693166/hypoxia-induced-autophagy-promotes-gemcitabine-resistance-in-human-bladder-cancer-cells-through-hypoxia-inducible-factor-1%C3%AE-activation
#7
Xiaoyu Yang, Hubin Yin, Yunzhi Zhang, Xinyuan Li, Hang Tong, Yizhou Zeng, Quan Wang, Weiyang He
Overcoming the chemoresistance of bladder cancer is a pivotal obstacle in clinical treatments. Hypoxia widely exists in solid tumors and has been demonstrated to contribute to chemoresistance through hypoxia-inducible factor 1α (HIF‑1α)-mediated autophagy in several types of cancer. However, it is unclear whether HIF‑1α-mediated autophagy and chemoresistance occur in bladder cancer. The present study demonstrated that HIF‑1α was overexpressed in 20 bladder cancer tissues compared with matched paracarcinoma tissues...
April 24, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29676857/proteomics-analysis-reveals-abnormal-electron-transport-and-excessive-oxidative-stress-cause-mitochondrial-dysfunction-in-placental-tissues-of-early-onset-preeclampsia
#8
Zhongwei Xu, Xiaohan Jin, Wei Cai, Maobin Zhou, Ping Shao, Zhen Yang, Rong Fu, Jin Cao, Yan Liu, Fang Yu, Rong Fan, Yan Zhang, Shuang Zou, Xin Zhou, Ning Yang, Xu Chen, Yuming Li
PURPOSE: Early-onset preeclampsia (EOS-PE) refers to preeclampsia that occurred before 34 gestation weeks. This study was conducted to explore the relationship between mitochondrial dysfunction and the pathogenesis of EOS-PE using proteomic strategy. EXPERIMENTAL DESIGN: To identify altering expressed mitochondrial proteins between severe EOS-PE and healthy pregnancies, enrichment of mitochondria coupled with iTRAQ-based quantitative proteomic method was performed...
April 20, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29674976/neocytolysis-how-to-get-rid-of-the-extra-erythrocytes-formed-by-stress-erythropoiesis-upon-descent-from-high-altitude
#9
REVIEW
Heimo Mairbäurl
Neocytolysis is the selective destruction of those erythrocytes that had been formed during stress-erythropoiesis in hypoxia in order to increase the oxygen transport capacity of blood. Neocytolysis likely aims at decreasing this excess amount of erythrocytes and hemoglobin (Hb) when it is not required anymore and to decrease blood viscosity. Neocytolysis seems to occur upon descent from high altitude. Similar processes seem to occur in microgravity, and are also discussed to mediate the replacement of erythrocytes containing fetal hemoglobin (HbF) with those having adult hemoglobin (HbA) after birth...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29673238/association-of-exercise-induced-autophagy-upregulation-and-apoptosis-suppression-with-neuroprotection-against-pharmacologically-induced-parkinson-s-disease
#10
Yong Chul Jang, Dong Joo Hwang, Jung Hoon Koo, Hyun Seob Um, Nam Hee Lee, Dong Cheol Yeom, Youngil Lee, Joon Yong Cho
PURPOSE: We investigated whether treadmill exercise (TE)-induced neuroprotection was associated with enhanced autophagy and reduced apoptosis in a mouse model of pharmacologically induced Parkinson's disease (PD). METHODS: PD was induced via the administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). C57BL/6 male mice were randomly assigned to the following three groups: control (C57BL, n=10), MPTP with probenecid (MPTP/C, n=10), and MPTP/ C plus exercise (MPTP-TE, n=10)...
March 30, 2018: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/29652869/effect-of-sustained-hypoxia-on-autophagy-of-genioglossus-muscle-derived-stem-cells
#11
Dongsheng Zhang, Shanshan Jia, Hengkun Wang, Shengyun Huang, Lili Xiao, Li Ma, Guangping Liu, Kun Gong, Le Xu
BACKGROUND Previous studies have demonstrated that sustained hypoxia in people with obstructive sleep apnea (OSA) impairs upper airway muscle activity, but the underlying mechanism remains poorly understood. As autophagy acts as an important regulator under hypoxia stress, we performed an in vitro investigation of the effects of sustained hypoxia on autophagy of genioglossus muscle-derived stem cells (GG MDSC), an important component of the upper airway muscle. MATERIAL AND METHODS Genioglossus MDSCs were obtained from Sprague-Dawley (SD) rats and identified by using immunofluorescence staining for CD34, Sca-1, and desmin...
April 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29626392/exercise-and-exercise-training-induced-increase-in-autophagy-markers-in-human-skeletal-muscle
#12
Nina Brandt, Thomas P Gunnarsson, Jens Bangsbo, Henriette Pilegaard
Moderately trained male subjects (mean age 25 years; range 19-33 years) completed an 8-week exercise training intervention consisting of continuous moderate cycling at 157 ± 20 W for 60 min (MOD; n = 6) or continuous moderate cycling (157 ± 20 W) interspersed by 30-sec sprints (473 ± 79 W) every 10 min (SPRINT; n = 6) 3 days per week. Sprints were followed by 3:24 min at 102 ± 17 W to match the total work between protocols. A muscle biopsy was obtained before, immediately and 2 h after the first training session as well as at rest after the training session...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29609842/akebia-saponin-d-alleviates-hepatic-steatosis-through-bnip3-induced-mitophagy
#13
Li-Li Gong, Song Yang, Wen Zhang, Fei-Fei Han, Ya-Li Lv, Zi-Rui Wan, He Liu, Yang-Jie Jia, Ling-Ling Xuan, Li-Hong Liu
Akebia Saponin D (ASD) is the most abundant constituent of the rhizome of Dipsacus asper Wall. The prior studies have shown that ASD alleviates hepatic steatosis targeted at the modulation of autophagy and exerts hepatoprotective effects through mitochondria. However, it is still unclear which signal transduction pathway that ASD increase autophagy and protect the mitochondria. The purpose of this paper was to explore the mechanisms through which ASD alleviates hepatic steatosis. ASD significantly reduced lipid accumulation in BRL cells...
December 1, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29587264/different-adaptive-responses-to-hypoxia-in-normal-and-multiple-myeloma-endothelial-cells
#14
Irene Filippi, Ilaria Saltarella, Carlo Aldinucci, Fabio Carraro, Roberto Ria, Angelo Vacca, Antonella Naldini
BACKGROUND/AIMS: Hypoxia is a powerful stimulator of angiogenesis under physiological as well as pathological conditions. Normal endothelial cells (EC), such as human umbilical vein EC (HUVEC), are relatively affected by hypoxic insult in terms of cell survival. In contrast, EC from tumors are particularly resistant to hypoxia-induced cell death. Previous reports have shown that EC in bone marrow from multiple myeloma (MM) patients had a hypoxic phenotype, even under normoxic conditions...
March 21, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29580989/amp-activated-protein-kinase-stabilizes-foxo3-in-primary-myotubes
#15
Anthony M J Sanchez, Robin Candau, Henri Bernardi
AMP-activated protein kinase (AMPK) is a critical enzyme in conditions of cellular energy deficit such as exercise, hypoxia or nutritional stress. AMPK is well known to regulate protein degradation pathways notably through FOXO-related axis. In this study, we investigated the implication of AMPK activation in FOXO3 expression and stability in skeletal muscle primary myotubes. First, time course and dose response studies revealed optimal AICAR treatment duration and dose in skeletal muscle cells. Then, experiments with cycloheximide treatment of primary myotubes highlighted that AICAR infusion extends FOXO3 protein half-life...
May 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29566574/bnip3-lc3-interaction-induces-mitophagy-in-spinal-cord-injury-in-rats-both-in-vivo-and-in-vitro
#16
Datang Yu, Mingfang Li, Piming Nie, Bing Ni, Zhengfeng Zhang, Yue Zhou
Autophagy and mitophagy have been shown to occur in spinal cord injury (SCI). Bcl-2/E1B-19KD-interacting protein 3 (BNIP3) and its homologue NIX have been implicated in the regulation of mitophagy. The aim of this work was to characterize the mechanisms and role of BNIP3 in SCI-associated mitophagy. Our data showed that BNIP3, targeted to mitochondria, interacted with microtubule-associated protein 1A/1B-light chain 3 (LC3), which is targeted to autophagosomes, thus forming a mitochondria-BNIP3-LC3-autophagosome complex and resulting in mitophagy...
March 23, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29559387/endurance-exercise-mediates-neuroprotection-against-mptp-mediated-parkinson-s-disease-via-enhanced-neurogenesis-antioxidant-capacity-and-autophagy
#17
Yongchul Jang, Insu Kwon, Wankeun Song, Ludmila M Cosio-Lima, Youngil Lee
Parkinson's disease (PD) is a neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra, leading to motor dysfunction. Growing evidence has demonstrated that endurance exercise (EE) confers neuroprotection against PD. However, the exact molecular mechanisms responsible for exercise-induced protection of dopaminergic neurons in PD remain unclear. Since oxidative stress plays a key role in the degenerative process of PD. We investigated whether EE-induced neuroprotection is associated with enhanced antioxidative capacity and autophagy, using a mouse model of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration...
May 21, 2018: Neuroscience
https://www.readbyqxmd.com/read/29540653/necrosis-in-human-neuronal-cells-exposed-to-paraquat
#18
Naho Hirayama, Toshihiko Aki, Takeshi Funakoshi, Kanako Noritake, Kana Unuma, Koichi Uemura
Paraquat (PQ) is an herbicide that was once used worldwide, but is now prohibited in many nations due to its high toxicity to humans. However, there are still rare cases of the fetal intoxication of PQ, which was purchased prior to the prohibition in Japan. In this study, several cell death pathways, the mitochondrial stress response, and autophagy were examined in SH-SY5Y cells exposed to PQ. The results reveal the decrease of a mitochondrial stress sensitive-BNIP3 (Bcl-2/adenovirus E1B 19-kDa-interacting protein 3) protein, the suppression of autophagic flux, and the lack of apoptosis as well as other regulated forms of necrosis, such as necroptosis and ferroptosis...
2018: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29538088/parkin-mediates-mitophagy-to-participate-in-cardioprotection-induced-by-late-exercise-preconditioning-but-bnip3-does-not
#19
Yang Yuan, Shan-Shan Pan
BACKGROUND: Late exercise preconditioning (LEP) is confirmed to have a protective effect on acute cardiovascular stress. However, the mechanisms by which mitophagy participates in exercise preconditioning (EP)-induced cardioprotection remain unclear. LEP may involve mitophagy mediated by the receptors PARK2 gene-encoded E3 ubiquitin ligase (Parkin) and BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3) to scavenge damaged mitochondria. METHODS: Our EP protocol involved four 10-minute periods of running, separated by 10-minute recovery intervals, plus a period of exhaustive running at 24 hours after EP...
May 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29502008/time-dependent-transcriptional-response-of-got1-human-small-intestine-neuroendocrine-tumor-after-177-lu-octreotate-therapy
#20
Johan Spetz, Nils Rudqvist, Britta Langen, Toshima Z Parris, Johanna Dalmo, Emil Schüler, Bo Wängberg, Ola Nilsson, Khalil Helou, Eva Forssell-Aronsson
INTRODUCTION: Patients with neuroendocrine tumors expressing somatostatin receptors are often treated with 177 Lu-octreotate. Despite being highly effective in animal models, 177 Lu-octreotate-based therapies in the clinical setting can be optimized further. The aims of the study were to identify and elucidate possible optimization venues for 177 Lu-octreotate tumor therapy by characterizing transcriptional responses in the GOT1 small intestine neuroendocrine tumor model in nude mice...
February 6, 2018: Nuclear Medicine and Biology
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