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https://www.readbyqxmd.com/read/29791899/national-practice-patterns-for-prenatal-monitoring-in-gastroschisis-gastroschisis-outcomes-of-delivery-good-provider-survey
#1
Ruchi Amin, Aaron Domack, Joseph Bartoletti, Erika Peterson, Britton Rink, Jennifer Bruggink, Melissa Christensen, Anthony Johnson, William Polzin, Amy J Wagner
BACKGROUND: Gastroschisis is an abdominal wall defect with increasing incidence. Given the lack of surveillance guidelines among maternal-fetal medicine (MFM) specialists, this study describes current practices in gastroschisis management. MATERIALS AND METHODS: An online survey was administered to MFM specialists from institutions affiliated with the North American Fetal Therapy Network (NAFTNet). Questions focused on surveillance timing, testing, findings that changed clinical management, and delivery plan...
May 23, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29782818/antimicrobial-activity-profiles-of-amphiphilic-xanthone-derivatives-are-a-function-of-their-molecular-oligomerization
#2
Jun-Jie Koh, Shuimu Lin, Yang Bai, Wendy Wan Ling Sin, Thet Tun Aung, Jianguo Li, Verma Chandra, Konstantin Pervushin, Roger W Beuerman, Shouping Liu
Currently, membrane-targeting small antimicrobial peptidomimetics (SAP) are important in antibiotic development because bacteria appear to develop resistance to these surface-active compounds less readily. However, the molecular membrane-targeting action of SAPs has received little attention. In this study, we investigated the effect of oligomerization of amphiphilic xanthone, a model SAP, on its antimicrobial properties against both Gram-positive and Gram-negative bacteria. First, oligomer formation by an amphiphilic xanthone, compound 2 (also coded as AM052), was investigated via solution-state nuclear magnetic resonance (NMR) spectroscopy...
May 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29763836/salicylic-acid-and-nitric-oxide-alleviate-high-temperature-induced-oxidative-damage-in-lablab-purpureus-l-plants-by-regulating-bio-physical-processes-and-dna-methylation
#3
Krishna Kumar Rai, Nagendra Rai, Shashi Pandey Rai
Salicylic acid (SA) and sodium nitroprusside (SNP, NO donor) modulates plant growth and development processes and recent findings have also revealed their involvement in the regulation of epigenetic factors under stress condition. In the present study, some of these factors were comparatively studied in hyacinth bean plants subjected to high temperature (HT) environment (40-42 °C) with and without exogenous application of SA and SNP under field condition. Exogenous application of SA and SNP substantially modulated the growth and biophysical process of hyacinth bean plants under HT environment...
April 26, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29762619/isolation-and-genome-sequencing-of-individual-circulating-tumor-cells-using-hydrogel-encapsulation-and-laser-capture-microdissection
#4
Emily S Park, Justin P Yan, Richard A Ang, Jeong Hyun Lee, Xiaoyan Deng, Simon P Duffy, Kevin Beja, Matti Annala, Peter C Black, Kim N Chi, Alexander W Wyatt, Hongshen Ma
Circulating tumor cells (CTCs) are malignant cells released into the bloodstream with the potential to form metastases in secondary sites. These cells, acquired non-invasively, represent a sample of highly relevant tumor tissue that is an alternative to difficult and low-yield tumor biopsies. In recent years, there has been growing interest in genomic profiling of CTCs to enable longitudinal monitoring of the tumor's adaptive response to therapy. However, due to their extreme rarity, genotyping CTCs has proved challenging...
May 15, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29750228/hypertension-among-newly-diagnosed-diabetic-patients-at-mulago-national-referral-hospital-in-uganda-a-cross-sectional-study
#5
Martin Muddu, Edrisa Mutebi, Isaac Ssinabulya, Samuel Kizito, Charles Kiiza Mondo
BACKGROUND: The prevalence of hypertension in patients with diabetes is approximately two-fold higher than in age-matched subjects without the disease and, conversely, individuals with hypertension are at increased risk of developing diabetes compared with normotensive persons. Up to 75% of cases of cardiovascular disease (CVD) in patients with diabetes are attributed to hypertension. Diabetics who have hypertension are more likely to develop complications and die, and appropriate blood pressure control in these individuals reduces the risk...
April 20, 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29723433/standardized-extract-of-wild-apple-fruit-in-alkyl-polyglucoside-based-cosmetic-cream-estimation-of-stability-safety-antioxidant-activity-and-efficiency
#6
Dragana Stojiljković, Vanja Tadić, Milica Stanković, Sonja Roganović, Ivana Arsić
OBJECTIVE: The aim of this study was in vitro and in vivo characterization of cosmetic cream with 6% of wild apple fruit water extract, containing 3.5% of alpha-hydroxyacids-AHAs and polyphenolic compounds, stabilized by biodegradable alkyl-polyglucoside emulsifiers. METHODS: In vitro characterization of cream included organoleptic and physico-chemical (pH values and electrical conductivity) analysis, antioxidant activity-AA estimation (using DPPH test) during 180 days of storage at 22±2°C and determination of cosmetic active substances content-AHAs (using HPLC analysis)...
May 3, 2018: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29716356/magnetic-tweezers-optimized-to-exert-high-forces-over-extended-distances-from-the-magnet-in-multicellular-systems
#7
L Selvaggi, L Pasakarnis, D Brunner, C M Aegerter
Magnetic tweezers are mainly divided into two classes depending on the ability of applying torque or forces to the magnetic probe. We focused on the second category and designed a device composed by a single electromagnet equipped with a core having a special asymmetric profile to exert forces as large as 230 pN-2.8 μm Dynabeads at distances in excess of 100 μm from the magnetic tip. Compared to existing solutions our magnetic tweezers overcome important limitations, opening new experimental paths for the study of a wide range of materials in a variety of biophysical research settings...
April 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29702678/expression-of-the-eight-gabaa-receptor-%C3%AE-subunits-in-the-developing-zebrafish-central-nervous-system
#8
Bryan Monesson-Olson, Jon J McClain, Abigail E Case, Hanna E Dorman, Daniel R Turkewitz, Aaron B Steiner, Gerald B Downes
GABA is a robust regulator of both developing and mature neural networks. It exerts many of its effects through GABAA receptors, which are heteropentamers assembled from a large array of subunits encoded by distinct genes. In mammals, there are 19 different GABAA subunit types, which are divided into the α, β, γ, δ, ε, π, θ and ρ subfamilies. The immense diversity of GABAA receptors is not fully understood. However, it is known that specific isoforms, with their distinct biophysical properties and expression profiles, tune responses to GABA...
2018: PloS One
https://www.readbyqxmd.com/read/29686667/-streptococcus-agalactiae-non-pilus-cell-wall-anchored-proteins-involvement-in-colonization-and-pathogenesis-and-potential-as-vaccine-candidates
#9
REVIEW
Giampiero Pietrocola, Carla Renata Arciola, Simonetta Rindi, Lucio Montanaro, Pietro Speziale
Group B Streptococcus (GBS) remains an important etiological agent of several infectious diseases including neonatal septicemia, pneumonia, meningitis, and orthopedic device infections. This pathogenicity is due to a variety of virulence factors expressed by Streptococcus agalactiae . Single virulence factors are not sufficient to provoke a streptococcal infection, which is instead promoted by the coordinated activity of several pathogenicity factors. Such determinants, mostly cell wall-associated and secreted proteins, include adhesins that mediate binding of the pathogen to host extracellular matrix/plasma ligands and cell surfaces, proteins that cooperate in the invasion of and survival within host cells and factors that neutralize phagocytosis and/or modulate the immune response...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29680082/no-197a-fetal-health-surveillance-antepartum-consensus-guideline
#10
Robert Liston, Diane Sawchuck, David Young
OBJECTIVE: This guideline provides new recommendations pertaining to the application and documentation of fetal surveillance in the antepartum period that will decrease the incidence of birth asphyxia while maintaining the lowest possible rate of obstetrical intervention. Pregnancies with and without risk factors for adverse perinatal outcomes are considered. This guideline presents an alternative classification system for antenatal fetal non-stress testing to what has been used previously...
April 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29678547/pamam-dendrimers-as-a-carbamazepine-delivery-system-for-neurodegenerative-diseases-a-biophysical-and-nanotoxicological-characterization
#11
Daniela E Igartúa, Carolina S Martinez, C Facundo Temprana, Silvia Del V Alonso, M Jimena Prieto
Carbamazepine (CBZ) is an antiepileptic drug, which also could be used in the treatment of neurodegenerative diseases, such as the Alzheimer's disease. However, its use has been limited due to its low solubility, inefficient pharmacokinetic profiles, and multiple side effects. PAMAM dendrimers, ethylenediamine core, generation 4.0 (amine terminal groups) and 4.5 (carboxylate terminal groups) (DG4.0 and DG4.5 respectively) are polymers that can increase drug solubility through complexation. Thus, the aim of this work was to obtain and characterize complexes between CBZ and dendrimers...
April 17, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29670384/screening-and-management-of-gestational-diabetes-in-mexico-results-from-a-survey-of-multilocation-multi-health-care-institution-practitioners
#12
Livia Dainelli, Alberto Prieto-Patron, Irma Silva-Zolezzi, Sandra G Sosa-Rubi, Salvador Espino Y Sosa, Enrique Reyes-Muñoz, Ruy Lopez-Ridaura, Patrick Detzel
Purpose: To identify the most common practices implemented for the screening and treatment of gestational diabetes mellitus (GDM) and to estimate the GDM clinician-reported proportion as a proxy of the incidence in Mexico. Materials and methods: Three hundred fifty-seven physicians in four major cities were asked about their practices regarding GDM screening, treatment, clinical exams, and health care staff involved in case of GDM diagnosis, as well as the percentage of women with GDM they care for...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29649333/soluble-t-cell-receptor-design-influences-functional-yield-in-an-e-coli-chaperone-assisted-expression-system
#13
Kristin Støen Gunnarsen, Lene Støkken Høydahl, Ralf Stefan Neumann, Kaare Bjerregaard-Andersen, Nicolay Rustad Nilssen, Ludvig Magne Sollid, Inger Sandlie, Geir Åge Løset
There is a quest for production of soluble protein of high quality for the study of T-cell receptors (TCRs), but expression often results in low yields of functional molecules. In this study, we used an E. coli chaperone-assisted periplasmic production system and compared expression of 4 different soluble TCR formats: single-chain TCR (scTCR), two different disulfide-linked TCR (dsTCR) formats, and chimeric Fab (cFab). A stabilized version of scTCR was also included. Additionally, we evaluated the influence of host (XL1-Blue or RosettaBlueTM) and the effect of IPTG induction on expression profiles...
2018: PloS One
https://www.readbyqxmd.com/read/29643075/widespread-changes-in-transcriptome-profile-of-human-mesenchymal-stem-cells-induced-by-two-dimensional-nanosilicates
#14
James K Carrow, Lauren M Cross, Robert W Reese, Manish K Jaiswal, Carl A Gregory, Roland Kaunas, Irtisha Singh, Akhilesh K Gaharwar
Two-dimensional nanomaterials, an ultrathin class of materials such as graphene, nanoclays, transition metal dichalcogenides (TMDs), and transition metal oxides (TMOs), have emerged as a new generation of materials due to their unique properties relative to macroscale counterparts. However, little is known about the transcriptome dynamics following exposure to these nanomaterials. Here, we investigate the interactions of 2D nanosilicates, a layered clay, with human mesenchymal stem cells (hMSCs) at the whole-transcriptome level by high-throughput sequencing (RNA-seq)...
April 11, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29642500/antibacterial-free-fatty-acids-and-monoglycerides-biological-activities-experimental-testing-and-therapeutic-applications
#15
REVIEW
Bo Kyeong Yoon, Joshua A Jackman, Elba R Valle-González, Nam-Joon Cho
Antimicrobial lipids such as fatty acids and monoglycerides are promising antibacterial agents that destabilize bacterial cell membranes, causing a wide range of direct and indirect inhibitory effects. The goal of this review is to introduce the latest experimental approaches for characterizing how antimicrobial lipids destabilize phospholipid membranes within the broader scope of introducing current knowledge about the biological activities of antimicrobial lipids, testing strategies, and applications for treating bacterial infections...
April 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29607579/ultrasonographic-prediction-of-antepartum-deterioration-of-growth-restricted-fetuses-after-late-preterm
#16
Ryo Yamamoto, Keisuke Ishii, Erika Nakajima, Jun Sasahara, Nobuaki Mitsuda
AIM: To examine the predictive value of ultrasound parameters for antepartum non-reassuring fetal status (NRFS) in fetal growth restriction (FGR) cases after late preterm. METHODS: Retrospective review of singleton FGR cases before 37 weeks gestation who delivered after 34 weeks gestation was performed. The association between ultrasound parameters that was assessed from 34 to 36 weeks gestation and the development of antepartum NRFS that was diagnosed by nonstress test and biophysical profile was analyzed by using multivariate Cox proportional hazards analyses...
April 2, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29606083/carbohydrate-based-heteronuclear-complexes-as-topoisomerase-i%C3%AE-inhibitor-approach-towards-anticancer-chemotherapeutics
#17
Mohd Afzal, Hamad A Al Lohedan, Mohammad Usman, Sartaj Tabassum
Due to the critical role of cellular enzymes necessary for cell proliferation by deciphering topological hurdles in the process of DNA replication, topoisomerases have been one of the major targets in the anticancer drug development area. A need, therefore, arises for new metallodrugs that specifically recognizes DNA and inhibits the activity of topoisomerase enzymes, herein, we report the synthesis and characterisation of new metal-based glycoconjugate entities containing heterobimetallic core CuII -SnIV (1) and NiII -SnIV (2) derived from N-glycoside ligand (L)...
March 31, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29604370/the-application-of-step-technology%C3%A2-for-particle-and-protein-dispersion-detection-studies-in-biopharmaceutical-research
#18
J Gross, N Herrmann, M Blech, S R Pinnapireddy, P Garidel, U Bakowsky
Particle detection and analysis techniques are essential in biopharmaceutical industries to evaluate the quality of various parenteral formulations regarding product safety, product quality and to meet the regulations set by the authority agencies. Several particle analysis systems are available on the market, but for the operator, it is quite challenging to identify the suitable method to analyze the sample. At the same time these techniques are the basis to gain a better understanding in biophysical processes, e...
March 28, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29581440/three-dimensional-epigenome-statistical-model-genome-wide-chromatin-looping-prediction
#19
Ziad Al Bkhetan, Dariusz Plewczynski
This study aims to understand through statistical learning the basic biophysical mechanisms behind three-dimensional folding of epigenomes. The 3DEpiLoop algorithm predicts three-dimensional chromatin looping interactions within topologically associating domains (TADs) from one-dimensional epigenomics and transcription factor profiles using the statistical learning. The predictions obtained by 3DEpiLoop are highly consistent with the reported experimental interactions. The complex signatures of epigenomic and transcription factors within the physically interacting chromatin regions (anchors) are similar across all genomic scales: genomic domains, chromosomal territories, cell types, and different individuals...
March 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29581149/high-resolution-definition-of-humoral-immune-response-correlates-of-effective-immunity-against-hiv
#20
Galit Alter, Karen G Dowell, Eric P Brown, Todd J Suscovich, Anastassia Mikhailova, Alison E Mahan, Bruce D Walker, Falk Nimmerjahn, Chris Bailey-Kellogg, Margaret E Ackerman
Defining correlates of immunity by comprehensively interrogating the extensive biological diversity in naturally or experimentally protected subjects may provide insights critical for guiding the development of effective vaccines and antibody-based therapies. We report advances in a humoral immunoprofiling approach and its application to elucidate hallmarks of effective HIV-1 viral control. Systematic serological analysis for a cohort of HIV-infected subjects with varying viral control was conducted using both a high-resolution, high-throughput biophysical antibody profiling approach, providing unbiased dissection of the humoral response, along with functional antibody assays, characterizing antibody-directed effector functions such as complement fixation and phagocytosis that are central to protective immunity...
March 26, 2018: Molecular Systems Biology
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