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https://www.readbyqxmd.com/read/29245176/high-risk-of-hypogonadism-in-young-male-cancer-survivors
#1
S Isaksson, K Bogefors, O Ståhl, J Eberhard, Y Lundberg Giwercman, I Leijonhufvud, K Link, I Øra, P Romerius, J Bobjer, A Giwercman
OBJECTIVE: Cancer and its treatment in childhood and young adulthood can cause hypogonadism, leading to increased risk of long term morbidity and mortality. The aim of this study was to evaluate the risk of presenting with biochemical signs of hypogonadism in testicular cancer survivors (TCS) and male childhood cancer survivors (CCS) in relation to the type of treatment given. DESIGN: Case-control study. PATIENTS: Ninety-two TCS, 125 CCS (mean age 40 and median age 34 years, respectively; mean follow-up time 9...
December 15, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29245153/catheter-ablation-of-focal-atrial-tachycardia-using-remote-magnetic-navigation
#2
Xiao-Yu Liu, Peter Karl Jacobsen, Steen Pehrson, Xu Chen
OBJECTIVES: The outcomes of catheter ablation in focal atrial tachycardia (AT) using remote magnetic navigation (RMN) are still controversial. The objectives of this study were to assess the acute and long-term outcomes of catheter ablation in focal AT using RMN. BACKGROUND: A total of 53 patients with focal AT who underwent catheter ablation using RMN were included. Thirty-six patients had structural heart disease, including previous atrial fibrillation ablation and heart surgery (abnormal group), and the remaining 17 patients had no structural heart disease (normal group)...
December 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29245141/a-systematic-review-of-the-state-of-the-literature-on-sexually-exploited-boys-internationally
#3
Melissa Moynihan, Katherine Mitchell, Claire Pitcher, Farinaz Havaei, Max Ferguson, Elizabeth Saewyc
This systematic review assessed the current state of the literature on sexually exploited boys internationally. We aimed to describe what is known about sexual exploitation of boys, identify gaps in the literature, provide implications for practice, and make recommendations for future research. Multiple database searches were conducted using a combination of controlled vocabulary and keywords to capture child and adolescent sexual exploitation. Our search identified 11,099 unique references and excluded studies that did not include male participants less than 18 years old or disaggregate results by relevant age groups and/or by sex...
December 12, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29245110/uncovering-the-mysteries-of-inclusion-empirical-and-methodological-possibilities-in-participatory-evaluation-in-an-international-context
#4
Jill Anne Chouinard, Peter Milley
The inclusion of stakeholders in participatory evaluation in highly diverse, culturally complex settings remains a challenge, given issues of inequity, power, voice, capacity and skill. These challenges are well documented, but there is a relative absence of papers devoted to addressing them based on examples and evidence. In this paper, we report our review of 51 empirical studies of participatory evaluations conducted in the international domain, focusing on the methods of inclusion used in the evaluations...
December 8, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29245099/total-bilateral-tmj-reconstruction-for-pain-and-dysfunction-case-report
#5
Carlos Vinícius Ayres Moreira, André Victor Pinto Serra, Larissa Oliveira Ramos Silva, Ana Carolina Fraga Fernandes, Roberto Almeida de Azevedo
INTRODUCTION: Temporomandibular disorders encompass a set of clinical conditions that affect the temporomandibular joint, the masticatory muscles and the associated tissues. Many therapeutic alternatives can be considered, being divided into non-invasive, minimally invasive and invasive interventions. This work aims to report a case of inflammatory joint pain and dysfunction treated with bilateral TMJ full reconstruction with alloplastic prosthesis stock. CASE REPORT: Patient D...
December 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29245056/subcutaneous-trastuzumab-herceptin-versus-intravenous-trastuzumab-for-the-treatment-of-patients-with-her2-positive-breast-cancer-a-time-motion-and-cost-assessment-study-in-a-lean-operating-day-care-oncology-unit
#6
Wiebren A A Tjalma, Tom Van den Mooter, Tim Mertens, Valerie Bastiaens, Manon T Huizing, Konstantinos Papadimitriou
OBJECTIVE: The subcutaneous (SC) formulation of trastuzumab represents an alternative to the intravenous (IV) infusion in the treatment of patients with HER2-positive metastatic and early breast cancer. We compared the two formulations in terms of time and cost differential. STUDY DESING: We conducted a time, motion and cost assessment study in a lean operating day care oncology unit to determine and compare the time and costs of trastuzumab SC versus IV administration in patients with HER2-positive breast cancer...
December 7, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29245048/the-time-dependent-prognostic-value-of-intratumoral-cytokine-expression-profiles-in-a-natural-course-of-primary-breast-cancer-with-a-long-term-follow-up
#7
Nataša Todorović-Raković, Marko Radulovic, Tijana Vujasinović, Jelena Milovanović, Dragica Nikolić-Vukosavljević
Despite the increasing evidence for the importance of immunity in breast cancer, the contradictory role of inflammation has not been thoroughly researched. In this study, we investigate the prognostic value of intratumoral inflammation as evaluated by cytokine mRNA levels. Intratumoral mRNA was measured for IL1β, IL6, IL8, IL10 and IL17A, using Taqman quantitative PCR. By the AUC criteria, none of the cytokines associated with metastasis outcome over the entire follow-up period. However, separation of the follow-up period has revealed a time-dependent and robust prognostic association of IL β...
December 12, 2017: Cytokine
https://www.readbyqxmd.com/read/29245038/spatiotemporal-influence-of-temperature-air-quality-and-urban-environment-on-cause-specific-mortality-during-hazy-days
#8
Hung Chak Ho, Man Sing Wong, Lin Yang, Wenzhong Shi, Jinxin Yang, Muhammad Bilal, Ta-Chien Chan
Haze is an extreme weather event that can severely increase air pollution exposure, resulting in higher burdens on human health. Few studies have explored the health effects of haze, and none have investigated the spatiotemporal interaction between temperature, air quality and urban environment that may exacerbate the adverse health effects of haze. We investigated the spatiotemporal pattern of haze effects and explored the additional effects of temperature, air pollution and urban environment on the short-term mortality risk during hazy days...
December 12, 2017: Environment International
https://www.readbyqxmd.com/read/29245035/multiple-long-term-trends-and-trend-reversals-dominate-environmental-conditions-in-a-man-made-freshwater-reservoir
#9
Petr Znachor, Jiří Nedoma, Josef Hejzlar, Jaromír Seďa, Jiří Kopáček, David Boukal, Tomáš Mrkvička
Man-made reservoirs are common across the world and provide a wide range of ecological services. Environmental conditions in riverine reservoirs are affected by the changing climate, catchment-wide processes and manipulations with the water level, and water abstraction from the reservoir. Long-term trends of environmental conditions in reservoirs thus reflect a wider range of drivers in comparison to lakes, which makes the understanding of reservoir dynamics more challenging. We analysed a 32-year time series of 36 environmental variables characterising weather, land use in the catchment, reservoir hydrochemistry, hydrology and light availability in the small, canyon-shaped Římov Reservoir in the Czech Republic to detect underlying trends, trend reversals and regime shifts...
December 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29245021/google-and-suicides-what-can-we-learn-about-the-use-of-internet-to-prevent-suicides
#10
V Chandler
OBJECTIVES: This article studies the statistical relationship between the search propensity of suicide-related terms on Google and the number of suicides. STUDY DESIGN: Suicide mortality data from all American states from January 2006 to November 2014 (n = 5372) and data on Google search intensity for the same period was collected. METHODS: Regression analysis with dynamic components was performed to determine the relationship between search intensity and the number of suicides...
December 12, 2017: Public Health
https://www.readbyqxmd.com/read/29245000/does-traumatic-brain-injury-hold-the-key-to-the-alzheimer-s-puzzle
#11
Robert E Becker, Dimitrios Kapogiannis, Nigel H Greig
INTRODUCTION: Neurodegenerative disorders have been a graveyard for hundreds of well-intentioned efforts at drug discovery and development. Concussion and other traumatic brain injuries (TBIs) and Alzheimer's disease (AD) share many overlapping pathologies and possible clinical links. METHODS: We searched the literature since 1995 using MEDLINE and Google Scholar for the terms concussion, AD, and shared neuropathologies. We also studied a TBI animal model as a supplement to transgenic (Tg) mouse AD models for evaluating AD drug efficacy by preventing neuronal losses...
December 12, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29244967/diagnosis-and-treatment-of-chronic-wounds-current-standards-of-germany-s-initiative-for-chronic-wounds-e-v
#12
J Dissemond, A Bültemann, V Gerber, B Jäger, K Kröger, C Münter
The diagnosis and treatment of patients with chronic wounds is an enormous challenge in various disciplines of medicine. These very complex processes usually involve several experts of different medical specialties with varying educational backgrounds. A necessary basis for consistent communication and documentation is the use of unambiguous nomenclature. Therefore, the board of the German wound association, Initiative for Chronic Wounds (ICW) e.V., has started to define various terms and procedures. An easy to remember algorithm, in the form of the ABCDE rule, has been developed for the structured diagnosis of chronic wounds...
December 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29244952/metabolic-responses-of-mytilus-galloprovincialis-to-fullerenes-in-mesocosms-exposure-experiments
#13
Josep Sanchís, Marta Llorca, Mar Olmos, Gabriella Francesca Schirinzi, Cristina Bosch-Orea, Esteban Abad, Damia Barcelo, Marinella Farre
In this study, Mediterranean mussels (Mytilus galloprovincialis) were exposed through the diet to fullerene soot, at three concentrations in parallel to a control group. Their metabolomics response was assessed by high-performance liquid chromatography coupled to high-resolution mass spectrometry (HPLC-HRMS). The experiments were conducted in marine mesocosms, during 35 days (7 days of acclimatization, 21 days of exposure and 7 seven days of depuration). Real conditions were emulated in terms of physicochemical conditions of the habitat...
December 15, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29244898/climate-driven-diversity-change-in-annual-grasslands-drought-plus-deluge-does-not-equal-normal
#14
Susan P Harrison, Marina L LaForgia, Andrew M Latimer
Climate forecasts agree that increased variability and extremes will tend to reduce the availability of water in many terrestrial ecosystems. Increasingly severe droughts may be exacerbated both by warmer temperatures and by the relative unavailability of water that arrives in more sporadic and intense rainfall events. Using long-term data and an experimental water manipulation, we examined the resilience of a heterogeneous annual grassland community to a prolonged series of dry winters that led to a decline in plant species richness (2000-2014), followed by a near-record wet winter (2016-2017), a climatic sequence that broadly resembles the predicted future in its high variability...
December 15, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29244893/effectiveness-of-intra-articular-injections-of-sodium-hyaluronate-or-corticosteroids-for-intracapsular-temporomandibular-disorders-a-systematic-review-and-meta-analysis
#15
Marlon A Moldez, Victor R Camones, Guillermo E Ramos, Mariela Padilla, Reyes Enciso
AIMS: To assess the effectiveness of intra-articular injections of sodium hyaluronate (NaH) or corticosteroids (CS) for treatment of intracapsular temporomandibular disorders (TMD). METHODS: Single- or double-blinded randomized controlled trials (RCTs) on the effectiveness of NaH or CS injections, compared to each other or to placebo, for the treatment of intracapsular TMD due to osteoarthritis and/or internal joint derangement were analyzed in this systematic review and meta-analysis...
December 15, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29244886/the-modified-apically-repositioned-flap-technique-a-long-term-4-to-16-years-retrospective-study
#16
João Carnio, Paulo M Camargo, Perry R Klokkevold, Flavia Q Pirih
Attached gingiva is desirable for the maintenance of gingival health. Although many methods are used to increase the zone of attached gingiva, the modified apically repositioned flap (MARF) technique has the advantages of simplicity and predictability. The short-term follow-up of the MARF technique demonstrated an increase in keratinized tissue and attached gingiva. This study evaluated long-term results of the MARF technique as used to increase the apicocoronal dimensions of keratinized tissue and attached gingiva in 28 sites (25 patients; average follow-up of 9 years)...
December 15, 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29244857/maternal-plasma-angiogenic-and-inflammatory-factor-profiling-in-foetal-down-syndrome
#17
Monika Zbucka-Kretowska, Karol Charkiewicz, Joanna Goscik, Slawomir Wolczynski, Piotr Laudanski
OBJECTIVE AND DESIGN: Angiogenic factors are proteins that are related to certain foetal chromosomal abnormalities. The aim of this study was to determine the concentration of 60 angiogenic factors in the plasma of women with offspring possessing trisomy 21/Down syndrome (DS). METHOD: After analysing karyotyping results, we selected 20 patients with foetuses possessing DS, and for the control group, we selected 28 healthy patients with uncomplicated pregnancies who delivered healthy newborns at term (i...
2017: PloS One
https://www.readbyqxmd.com/read/29244852/proteometabolomic-response-of-deinococcus-radiodurans-exposed-to-uvc-and-vacuum-conditions-initial-studies-prior-to-the-tanpopo-space-mission
#18
Emanuel Ott, Yuko Kawaguchi, Denise Kölbl, Palak Chaturvedi, Kazumichi Nakagawa, Akihiko Yamagishi, Wolfram Weckwerth, Tetyana Milojevic
The multiple extremes resistant bacterium Deinococcus radiodurans is able to withstand harsh conditions of simulated outer space environment. The Tanpopo orbital mission performs a long-term space exposure of D. radiodurans aiming to investigate the possibility of interplanetary transfer of life. The revealing of molecular machinery responsible for survivability of D. radiodurans in the outer space environment can improve our understanding of underlying stress response mechanisms. In this paper, we have evaluated the molecular response of D...
2017: PloS One
https://www.readbyqxmd.com/read/29244841/individual-preferences-for-physical-exercise-as-secondary-prevention-for-non-specific-low-back-pain-a-discrete-choice-experiment
#19
Emmanuel Aboagye, Jan Hagberg, Iben Axén, Lydia Kwak, Malin Lohela-Karlsson, Eva Skillgate, Gunilla Dahlgren, Irene Jensen
BACKGROUND: Exercise is effective in improving non-specific low back pain (LBP). Certain components of physical exercise, such as the type, intensity and frequency of exercise, are likely to influence participation among working adults with non-specific LBP, but the value and relative importance of these components remain unknown. The study's aim was to examine such specific components and their influence on individual preferences for exercise for secondary prevention of non-specific LBP among working adults...
2017: PloS One
https://www.readbyqxmd.com/read/29244840/high-expression-of-lncrna-pvt1-independently-predicts-poor-overall-survival-in-patients-with-primary-uveal-melanoma
#20
Haiming Xu, Jingwen Gong, Hui Liu
The plasmacytoma variant translocation 1 gene (PVT1) plays an oncogenic role in the initiation and progression of multiple cancers. In this study, by using deep-sequencing data and follow-up data in the Cancer Genome Atlas-Uveal melanomas (TCGA-UVM), we assessed the association between the expression of PVT1 and clinicopathological characteristics of patients with uveal melanoma, the mechanism of its dysregulation and its prognostic value. Results showed that high PVT1 expression group had a higher proportion of epithelioid cell dominant disease (a more malignant histological subtype than spindle cell dominant disease) and more cases of extrascleral extension (a risk factor for metastasis) compared with the low PVT1 expression group...
2017: PloS One
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