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https://www.readbyqxmd.com/read/28738210/neural-activity-and-emotional-processing-following-military-deployment-effects-of-mild-traumatic-brain-injury-and-posttraumatic-stress-disorder
#1
Daniel V Zuj, Kim L Felmingham, Matthew A Palmer, Ellie Lawrence-Wood, Miranda Van Hooff, Andrew J Lawrence, Richard A Bryant, Alexander C McFarlane
Posttraumatic Stress Disorder (PTSD) and mild traumatic brain injury (mTBI) are common comorbidities during military deployment that affect emotional brain processing, yet few studies have examined the independent effects of mTBI and PTSD. The purpose of this study was to examine distinct differences in neural responses to emotional faces in mTBI and PTSD. Twenty-one soldiers reporting high PTSD symptoms were compared to 21 soldiers with low symptoms, and 16 soldiers who reported mTBI-consistent injury and symptoms were compared with 16 soldiers who did not sustain an mTBI...
July 21, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28737960/optimization-and-interpretation-of-serial-quantiferon-testing-to-measure-acquisition-of-m-tuberculosis-infection
#2
Elisa Nemes, Virginie Rozot, Hennie Geldenhuys, Nicole Bilek, Simbarashe Mabwe, Deborah Abrahams, Lebohang Makhethe, Mzwandile Erasmus, Alana Keyser, Asma Toefy, Yolundi Cloete, Frances Ratangee, Thomas Blauenfeldt, Morten Ruhwald, Gerhard Walzl, Bronwyn Smith, Andre G Loxton, Willem A Hanekom, Jason R Andrews, Maria D Lempicki, Ruth Ellis, Ann M Ginsberg, Mark Hatherill, Thomas J Scriba
RATIONALE: Conversion from a negative to positive QuantiFERON-TB test is indicative of Mycobacterium tuberculosis (M.tb) infection, which predisposes to tuberculosis disease. Interpretation of serial tests is confounded by immunological and technical variability. OBJECTIVES: To improve consistency of serial QuantiFERON-TB testing algorithms and provide a data-driven definition of conversion. METHODS: Sources of QuantiFERON-TB variability were assessed and optimal procedures identified...
July 24, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28737929/enhanced-degradation-of-tce-on-a-superfund-site-using-endophyte-assisted-poplar-tree-phytoremediation
#3
Sharon Lafferty Doty, John Leonard Freeman, Christopher M Cohu, Joel Gerard Burken, Andrea Firrincieli, Andrew Simon, Zareen Khan, Jud G Isebrands, Joseph Lukas, Michael J Blaylock
Trichloroethylene (TCE) is a widespread environmental pollutant common in groundwater plumes associated with industrial manufacturing areas. We had previously isolated and characterized a natural bacterial endophyte, Enterobacter sp. strain PDN3, of poplar trees, that rapidly metabolizes TCE, releasing chloride ion. We now report findings from a successful three-year field trial of endophyte-assisted phytoremediation on the Middlefield-Ellis-Whisman Superfund Study Area TCE plume in the Silicon Valley of California...
July 24, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28737893/uncondensed-graphitic-carbon-nitride-on-reduced-graphene-oxide-for-oxygen-sensing-via-a-photoredox-mechanism
#4
James E Ellis, Dan C Sorescu, Seth C Burkert, David L White, Alexander Star
Melon, a polymeric, uncondensed graphitic carbon nitride with a two-dimensional structure has been coupled with reduced graphene oxide (rGO) to create an oxygen chemiresistor sensor that is active under UV photoactivation. Oxygen gas is an important sensor target in a variety of areas including industrial safety, combustion process monitoring, as well as environmental and biomedical fields. Due to the intimate electrical interface formed between melon and rGO, charge transfer of photoexcited electrons occurs between the two materials when under UV (λ=365 nm) irradiation...
July 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28737454/bioactivity-of-epigallocatechin-gallate-nanoemulsions-evaluated-in-mice-model
#5
Antonios E Koutelidakis, Konstantina Argyri, Zoi Sevastou, Dimitra Lamprinaki, Elli Panagopoulou, Evi Paximada, Aggeliki Sali, Vassilis Papalazarou, Athanasios Mallouchos, Vasiliki Evageliou, Vasiliki Kostourou, Ioanna Mantala, Maria Kapsokefalou
The hypothesis that incorporation of epigallocatechin gallate (EGCG) into nanoemulsions may increase its bioactivity compared with EGCG aqueous solutions was examined in mice. After an in vitro study in a model system with stimulated gastrointestinal conditions, the following EGCG nanoemulsions were used in a mice experiment: Emulsion I: emulsion water in oil (W/O), which contained 0.23 mg/mL EGCG in aqueous phase; Emulsion II: emulsion oil in water (O/W), which contained 10% olive oil and 0.23 mg/mL esterified EGCG in fatty phase; and Emulsion III: emulsion O/W in water (W1/O/W2; 8:32:60), which contained 32% olive oil and 0...
July 24, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28736899/trajectories-of-depressive-and-anxiety-symptoms-in-older-adults-a-6-year-prospective-cohort-study
#6
Sophie E Holmes, Irina Esterlis, Carolyn M Mazure, Yen Ying Lim, David Ames, Stephanie Rainey-Smith, Chris Fowler, Kathryn Ellis, Ralph N Martins, Olivier Salvado, Vincent Doré, Victor L Villemagne, Christopher C Rowe, Simon M Laws, Colin L Masters, Robert H Pietrzak, Paul Maruff
OBJECTIVE: Depressive and anxiety symptoms are common in older adults, significantly affect quality of life, and are risk factors for Alzheimer's disease. We sought to identify the determinants of predominant trajectories of depressive and anxiety symptoms in cognitively normal older adults. METHOD: Four hundred twenty-three older adults recruited from the general community underwent Aβ positron emission tomography imaging, apolipoprotein and brain-derived neurotrophic factor genotyping, and cognitive testing at baseline and had follow-up assessments...
July 24, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28736462/sequential-release-of-multiple-drugs-from-flexible-drug-delivery-films
#7
Cheryl L Jennings, Ellis K Perry, Thomas D Dziubla, David A Puleo
Sequential release of drugs aligned with the phases of tissue healing could reduce scarring. To achieve this aim, layered film devices comprising cellulose acetate phthalate (CAP) and Pluronic F-127 (Pluronic) were loaded with ketoprofen, quercetin, and pirfenidone. Citrate plasticizers were added to impart flexibility. Release of two or three drugs in sequence over several days was obtained for all multilayered devices tested. Mechanical analysis showed that elongation increased and modulus decreased with increasing plasticizer content...
2017: International Journal of Polymeric Materials
https://www.readbyqxmd.com/read/28736315/the-spectrum-of-triple-negative-breast-disease-high-and-low-grade-lesions
#8
REVIEW
Felipe C Geyer, Fresia Pareja, Britta Weigelt, Emad Rakha, Ian O Ellis, Stuart J Schnitt, Jorge S Reis-Filho
Triple-negative breast cancer is viewed clinically as an aggressive subgroup of breast cancer. In fact, the majority of triple-negative breast cancers are poor-prognosis tumors with a complex genomic landscape. However, triple-negative disease is vastly heterogeneous, encompassing multiple entities with marked genetic, transcriptional, histological, and clinical differences, with neoplasms in this group ranging from low- to high-grade. Among the less common low-grade triple-negative lesions, two large subgroups, both with a rather indolent behavior, can be distinguished: a low-grade triple-negative breast neoplasia family, which includes nonobligate precursors of triple-negative breast cancer, and, despite being low-grade, harbor the complex genomic landscape of usual triple-negative breast cancer, and the salivary gland-like tumors of the breast, lacking all of the cardinal molecular features of conventional triple-negative breast cancer and underpinned by specific fusion-genes or hotspot mutations, which may be of diagnostic and possibly therapeutic utility...
July 20, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28736023/protective-effects-of-geniposide-on-hepatic-ischemia-reperfusion-injury
#9
Y-P Rong, H-T Huang, J-S Liu, L Wei
BACKGROUND: Geniposide (GEN) is the major ingredient of Gardenia jasminoides Ellis, which has anti-inflammatory and anti-apoptotic activities and is widely used to treat ischemia disease. Inflammation and apoptosis play an important role in hepatic ischemia/reperfusion (I/R) injury. The current study was conducted to explore the effects of geniposide on hepatic I/R injury and its potential molecular mechanism in mice. METHODS: Fifty Sprague-Dawley rats were randomly divided into 5 groups: the sham group (sham), the hepatic I/R injury group (IRI) and the GEN groups (low, middle, and high)...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28735850/enhanced-energetic-state-and-protection-from-oxidative-stress-in-human-myoblasts-overexpressing-bmi1
#10
Silvia Dibenedetto, Maria Niklison-Chirou, Claudia P Cabrera, Matthew Ellis, Lesley G Robson, Paul Knopp, Francesco Saverio Tedesco, Martina Ragazzi, Valentina Di Foggia, Michael R Barnes, Aleksandar Radunovic, Silvia Marino
The Polycomb group gene BMI1 is essential for efficient muscle regeneration in a mouse model of Duchenne muscular dystrophy, and its enhanced expression in adult skeletal muscle satellite cells ameliorates the muscle strength in this model. Here, we show that the impact of mild BMI1 overexpression observed in mouse models is translatable to human cells. In human myoblasts, BMI1 overexpression increases mitochondrial activity, leading to an enhanced energetic state with increased ATP production and concomitant protection against DNA damage both in vitro and upon xenografting in a severe dystrophic mouse model...
July 17, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28733087/unobtrusive-assessment-of-neonatal-sleep-state-based-on-heart-rate-variability-retrieved-from-electrocardiography-used-for-regular-patient-monitoring
#11
Jan Werth, Xi Long, Elly Zwartkruis-Pelgrim, Hendrik Niemarkt, Wei Chen, Ronald M Aarts, Peter Andriessen
As an approach of unobtrusive assessment of neonatal sleep state we aimed at an automated sleep state coding based only on heart rate variability obtained from electrocardiography used for regular patient monitoring. We analyzed active and quiet sleep states of preterm infants between 30 and 37weeks postmenstrual age. To determine the sleep states we used a nonlinear kernel support vector machine for sleep state separation based on known heart rate variability features. We used unweighted and weighted misclassification penalties for the imbalanced distribution between sleep states...
July 18, 2017: Early Human Development
https://www.readbyqxmd.com/read/28732815/2-year-outcomes-with-the-absorb-bioresorbable-scaffold-for-treatment-of-coronary-artery-disease-a-systematic-review-and-meta-analysis-of-seven-randomised-trials-with-an-individual-patient-data-substudy
#12
Ziad A Ali, Patrick W Serruys, Takeshi Kimura, Runlin Gao, Stephen G Ellis, Dean J Kereiakes, Yoshinobu Onuma, Charles Simonton, Zhen Zhang, Gregg W Stone
BACKGROUND: Bioresorbable vascular scaffolds (BVS) offer the potential to improve long-term outcomes of percutaneous coronary intervention after their complete bioresorption. Randomised trials have shown non-inferiority between BVS and metallic drug-eluting stents at 1 year in composite safety and effectiveness outcomes, although some increases in rates of target vessel-related myocardial infarction and device thrombosis were identified. Outcomes of BVS following the first year after implantation are unknown...
July 18, 2017: Lancet
https://www.readbyqxmd.com/read/28732758/effects-of-narrator-empathy-in-a-computer-delivered-brief-intervention-for-alcohol-use
#13
Jennifer D Ellis, Emily R Grekin, Jessica R Beatty, Lucy McGoron, Benjamin V LaLiberte, Damaris E Pop, Anthony P Kostecki, Steven J Ondersma
Computer-delivered, brief interventions (CDBIs) have been an increasingly popular way to treat alcohol use disorders; however, very few studies have examined which characteristics of CDBIs maximize intervention effectiveness. The literature has consistently demonstrated that therapist empathy is associated with reduced substance use in in-person therapy; however, it is unclear whether this principle applies to CDBIs. Therefore, the study aimed to examine whether the presence of an empathic narrator increased intentions to reduce heavy drinking in a CDBI...
July 18, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28730129/bilateral-uveitis-associated-with-nivolumab-therapy-for-metastatic-melanoma-a-case-report
#14
Daniel Russell Richardson, Brian Ellis, Inderjit Mehmi, Monique Leys
No abstract text is available yet for this article.
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28729967/tesevatinib-ameliorates-progression-of-polycystic-kidney-disease-in-rodent-models-of-autosomal-recessive-polycystic-kidney-disease
#15
William E Sweeney, Philip Frost, Ellis D Avner
AIM: To investigate the therapeutic potential of tesevatinib (TSV), a unique multi-kinase inhibitor currently in Phase II clinical trials for autosomal dominant polycystic kidney disease (ADPKD), in well-defined rodent models of autosomal recessive polycystic kidney disease (ARPKD). METHODS: We administered TSV in daily doses of 7.5 and 15 mg/kg per day by I.P. to the well characterized bpk model of polycystic kidney disease starting at postnatal day (PN) 4 through PN21 to assess efficacy and toxicity in neonatal mice during postnatal development and still undergoing renal maturation...
July 6, 2017: World Journal of Nephrology
https://www.readbyqxmd.com/read/28729411/recognized-obstructive-sleep-apnea-is-associated-with-improved-in-hospital-outcomes-after-st-elevation-myocardial-infarction
#16
Divyanshu Mohananey, Pedro A Villablanca, Tanush Gupta, Sahil Agrawal, Michael Faulx, Venugopal Menon, Samir R Kapadia, Brian P Griffin, Stephen G Ellis, Milind Y Desai
BACKGROUND: Obstructive sleep apnea (OSA) is an independent risk factor for many cardiovascular conditions such as coronary artery disease, myocardial infarction, systemic hypertension, pulmonary hypertension, and stroke. However, the association of OSA with outcomes in patients hospitalized for ST-elevation myocardial infarction remains controversial. METHODS AND RESULTS: We used the nation-wide inpatient sample between 2003 and 2011 to identify patients with a primary discharge diagnosis of ST-elevation myocardial infarction and then used the International Classification of Diseases, Clinical Modification code 327...
July 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28729408/femoral-artery-atherosclerosis-is-associated-with-physical-function-across-the-spectrum-of-the-ankle-brachial-index-the-san-diego-population-study
#17
Christina L Wassel, Alicia M Ellis, Natalie C Suder, Emma Barinas-Mitchell, Dena E Rifkin, Nketi I Forbang, Julie O Denenberg, Antoinette M Marasco, Belinda J McQuaide, Nancy S Jenny, Matthew A Allison, Joachim H Ix, Michael H Criqui
BACKGROUND: The ankle-brachial index (ABI) is inadequate to detect early-stage atherosclerotic disease, when interventions to prevent functional decline may be the most effective. We determined associations of femoral artery atherosclerosis with physical functioning, across the spectrum of the ABI, and within the normal ABI range. METHODS AND RESULTS: In 2007-2011, 1103 multiethnic men and women participated in the San Diego Population Study, and completed all components of the summary performance score...
July 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28729263/complete-genomic-sequence-of-canine-distemper-virus-from-an-ethiopian-wolf
#18
Denise A Marston, Jemma Watson, Emma L Wise, Richard J Ellis, Eric Bedin, Girma Ayalew, Muktar Abute, Xavier de Lamballerie, Anthony R Fooks, Claudio Sillero-Zubiri, Ashley C Banyard
Canine distemper virus (CDV) has been implicated in population declines of wildlife, including many threatened species. Here we present the full genome of CDV from an Ethiopian wolf, Canis simensis, the world's rarest and most endangered canid.
July 20, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28727749/student-perception-of-group-dynamics-predicts-individual-performance-comfort-and-equity-matter
#19
Elli J Theobald, Sarah L Eddy, Daniel Z Grunspan, Benjamin L Wiggins, Alison J Crowe
Active learning in college classes and participation in the workforce frequently hinge on small group work. However, group dynamics vary, ranging from equitable collaboration to dysfunctional groups dominated by one individual. To explore how group dynamics impact student learning, we asked students in a large-enrollment university biology class to self-report their experience during in-class group work. Specifically, we asked students whether there was a friend in their group, whether they were comfortable in their group, and whether someone dominated their group...
2017: PloS One
https://www.readbyqxmd.com/read/28727747/plant-species-dispersed-by-galapagos-tortoises-surf-the-wave-of-habitat-suitability-under-anthropogenic-climate-change
#20
Diego Ellis-Soto, Stephen Blake, Alaaeldin Soultan, Anne Guézou, Fredy Cabrera, Stefan Lötters
Native biodiversity on the Galapagos Archipelago is severely threatened by invasive alien species. On Santa Cruz Island, the abundance of introduced plant species is low in the arid lowlands of the Galapagos National Park, but increases with elevation into unprotected humid highlands. Two common alien plant species, guava (Psidium guajava) and passion fruit (Passiflora edulis) occur at higher elevations yet their seeds are dispersed into the lowlands by migrating Galapagos tortoises (Chelonoidis spp.). Tortoises transport large quantities of seeds over long distances into environments in which they have little or no chance of germination and survival under current climate conditions...
2017: PloS One
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