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https://www.readbyqxmd.com/read/29731577/expression-of-ki-67-in-odontogenic-cysts-a-comparative-study-between-odontogenic-keratocysts-radicular-cysts-and-dentigerous-cysts
#1
Tapan G Modi, Monali Chalishazar, Malay Kumar
Introduction and Objectives: Odontogenic cysts are the most common cysts of the jaws and are formed from the remnants of the odontogenic apparatus. Among these odontogenic cysts, radicular cysts (RCs) (about 60% of all diagnosed jaw cysts), dentigerous cysts (DCs) (16.6% of all jaw cysts) and odontogenic keratocysts (OKCs) (11.2% of all developmental odontogenic cysts) are the most common. The behavior of any lesion is generally reflected by its growth potential. Growth potential is determined by measuring the cell proliferative activity...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29685058/the-effect-of-open-vs-closed-kinetic-chain-exercises-on-anterior-tibial-laxity-strength-and-function-following-anterior-cruciate-ligament-reconstruction-a-systematic-review-and-meta-analysis
#2
Alyssa Perriman, Edmund Leahy, Adam Ivan Semciw
Study Design Systematic review with meta-analysis. Background There is controversy surrounding the early use of Open Kinetic Chain (OKC) quadriceps strengthening exercises post anterior cruciate ligament reconstruction (ACLR) due to the belief that increased strain in the graft could cause damage. Objectives To determine if OKC quadriceps exercises result in differences in anterior tibial laxity, strength, function, quality of life or adverse events in the ACLR population, when compared to closed kinetic chain (CKC) quadriceps exercises...
April 23, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29672163/an-unusual-case-of-an-odontogenic-keratocyst-associated-with-an-ungrafted-alveolar-cleft-a-case-report-and-review-of-the-literature
#3
Sapna Radia, Alexander C Cash, Kanwalraj Moar
We describe an unusual case of an odontogenic keratocyst (OKC) associated with an ungrafted left-sided alveolar cleft in a 10-year-old male patient. There is no previous report in the literature of OKC or other dental cysts associated with an alveolar cleft. We discuss the management of the OKC prior to secondary bone grafting and present this case to highlight the difficulty in the management of OKC concurrent with grafting of the alveolar cleft site, the proximity of unerupted permanent teeth, and possible treatment modalities...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29621081/odontogenic-keratocysts-as-first-manifestation-of-nevoid-basal-cell-carcinoma-syndrome-surgical-management-and-immunohistochemical-analysis
#4
Jessica Luana Dos Santos, Renata Zoraida Rizental Delgado, Greison Rabelo de Oliveira, Ana Lúcia Carrinho Ayroza Rangel
Nevoid Basal Cell Carcinoma Syndrome (NBCCS), also known as Gorlin syndrome, is a rare autosomal dominant disorder, with no gender predilection. Individuals with NBCCS are commonly diagnosed between 17 and 35 years old and can present multiple basal cell carcinomas scattered throughout the body, presence of recurrent and early-onset odontogenic keratocysts (OKCs) and skeletal abnormalities. This article describes a case of a 13-year-old white boy who referred complaining of facial asymmetry. Extraoral examination revealed volumetric increase displacing the nasal ala from the right side and extended to the zygomatic bone...
April 4, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29620170/increased-level-of-cell-derived-microparticles-in-the-cyst-fluids-of-odontogenic-keratocysts
#5
Qi-Wen Man, Wen-Qun Zhong, Jian-Gang Ren, Jin-Yuan Liu, Yue-Yu Zheng, Rui-Fang Li, B Fidele Nyimi, Gang Chen, Yi-Fang Zhao, Bing Liu
The aim of this study was to examine the level and basic characteristics of cell‑derived microparticles (MPs) in the cyst fluids of odontogenic keratocysts (OKCs). For this purpose, MPs from the cyst fluids (CFMPs) of OKCs were purified by a classic differential centrifugation method and characterized by a transmission electron microscope and fluorescence microscope. Flow cytometric analysis was used to determine the size, concentration and cellular origins of the CFMPs. Moreover, the expression level of receptor activator for nuclear factor‑κB ligand in the OKCs was evaluated by immunohistochemical staining and then analyzed for its correlation with the concentration of CFMPs by Spearman's rank correlation test...
April 5, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29564556/immunohistochemical-evaluation-of-sonic-hedgehog-signaling-pathway-proteins-shh-ptch1-ptch2-smo-gli1-gli2-and-gli3-in-sporadic-and-syndromic-odontogenic-keratocysts
#6
Ana Maria Hoyos Cadavid, E Kaminagakura, M F S D Rodrigues, C A L Pinto, T H N Teshima, F A Alves
AIMS: The aim of this study was to compare the clinical and demographic features of 62 patients presenting sporadic odontogenic keratocysts (OKCs) or OKCs associated with nevoid basal cell carcinoma syndrome (NBCCS). In conjunction with this, we also evaluated the immunohistochemical expression of Shh, Ptch1, Ptch2, Smo, Gli1, Gli2 and Gli3 proteins in 86 OKCs. By doing this, we add to the understanding of the biology of this type of lesion, providing tools that will help facilitate the early diagnosis of NBCCS in those patients where the first manifestation is that of OKCs...
March 21, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29530535/high-expression-of-collagen-xvii-compensates-for-its-depletion-induced-by-pemphigoid-igg-in-the-oral-mucosa
#7
Mayumi Kamaguchi, Hiroaki Iwata, Hideyuki Ujiie, Ken Natsuga, Wataru Nishie, Yoshimasa Kitagawa, Hiroshi Shimizu
The basement membrane zone consists of multiple components, including collagen XVII (COL17), which is the target of bullous pemphigoid. To our knowledge, no research has addressed the differences in basement membrane zone components between the skin and oral mucosa; therefore, we investigated the basement membrane zone proteins, with a focus on COL17. The mRNA and protein expression levels of COL17 were significantly higher in oral keratinocytes than in skin keratinocytes. Hemidesmosomal COL17 expression was markedly higher in oral keratinocytes than in skin keratinocytes, and its level was associated with adhesion strength...
March 9, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29521748/delayed-diagnosis-of-gorlin-goltz-syndrome-the-importance-of-the-multidisciplinary-approach
#8
Jéssica Araújo Figueira, Fábio Roberto de Souza Batista, Karina Rosso, Vanessa Cristina Veltrini, Angelo José Pavan
Gorlin-Goltz syndrome (GGS), also known as nevoid basal cell carcinoma syndrome, is an autosomal dominant inherited disorder with high penetrance and variable expressivity. The classic triad originally described by Gorlin and Goltz in 1960 is composed of multiple nevoid basal cell carcinomas (NBCCs), odontogenic keratocysts (OKCs) in the jaws and bifid ribs. in 1977, this triad was modified by Rayner et al, and to GGS diagnosis, the OKCs had to appear in combination with calcification of the cerebellar falx or palmar and plantar pits...
March 8, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29508125/investigation-of-clinicopathological-parameters-and-expression-of-cox-2-bcl-2-pcna-and-p53-in-primary-and-recurrent-sporadic-odontogenic-keratocysts
#9
Tomasz Kaczmarzyk, Konrad Kisielowski, Rafał Koszowski, Magdalena Rynkiewicz, Ewa Gawełek, Karolina Babiuch, Anna Bednarczyk, Bogna Drozdzowska
OBJECTIVES: Odontogenic keratocyst (OKC) presents considerable variation in aggressiveness and propensity for recurrence, yet hitherto, no explicit clinicopathological features have been determined to clearly demonstrate the potential for relapse. This retrospective study aims to investigate the prognostic relevance of various clinicopathological features as well as immunoexpression of COX-2, bcl-2, PCNA, and p53 in sporadic OKC. MATERIALS AND METHODS: Among 41 patients with OKC treated by enucleation, the frequency of recurrence for various clinicopathological features as well as immunoexpression for COX-2, bcl-2, PCNA, and p53 was evaluated...
March 5, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29491624/trigeminal-neuralgia-induced-by-odontogenic-keratocyst-associated-with-impacted-supernumerary-teeth-a-rare-case-report
#10
Annaji Araleri Gopalkrishna, B N Tejasree, M Manjunath, D P Ashwin
Odontogenic keratocyst(OKC)is a cyst oftooth origin with an aggressive behavior including a high recurrence rate, it has been rechristened to keratocystic odontogenic tumor(KCOT) as it be the reflects its neoplastic nature. We report a case of KCOT in association with an impacted supernumerary tooth along with Trigeminal Neuralgia, that subsided by itself after removal of the cyst.
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29491599/orthokeratinized-odontogenic-cyst-with-calcification-a-rare-case-report-of-a-distinct-entity
#11
Mamata Kamat, Sampada Kanitkar, Uma Datar, Sanjay Byakodi
Orthokeratinized odontogenic cyst (OOC) is a relatively rare odontogenic cyst, distinct from odontogenic keratocyst (OKC). In the 4th edition of WHO Classification of Head and Neck Tumors (2017), OOC has been included as a separate entity in the category of developmental odontogenic cysts. It presents as a unilocular radiolucent lesion in the posterior mandible and is frequently related to impacted teeth, thus mimicking dentigerous cyst. Due to low local aggressiveness and no association with nevoid basal cell carcinoma syndrome, it does not show tendency to recur...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29476674/apoptosis-and-cell-cycle-aberrations-in-epithelial-odontogenic-lesions-an-evidence-by-the-expression-of-p53-bcl-2-and-bax
#12
J-R Tenório, T Santana, S-I-M-L Queiroz, D-H-I-P de Oliveira, L-M-G Queiroz
BACKGROUND: Ameloblastoma (AMB), odontogenic keratocyst (OKC) and adenomatoid odontogenic tumor (AOT) are epithelial odontogenic lesions with diverse biologic profiles. Defects in regulation of apoptosis and cell cycle may be involved in the development and progression of those lesions, therefore we aimed to investigate the expression of Bcl-2, Bax and p53 to better understand the possible role of these proteins in AMBs, OKCs and AOTs. MATERIAL AND METHODS: The studied sample consisted of 20 AMBs, 20 OKCs and 20 AOTs...
March 1, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29472118/loss-of-heterozygosity-of-mir15a-mir16-1-negative-regulators-of-the-antiapoptotic-gene-bcl2-is-not-common-in-odontogenic-keratocysts
#13
Taynara Asevedo Campos de Resende, Vanessa de Fátima Bernardes, Jéssica Carolina da Silva, Luiz Armando De Marco, Ricardo Santiago Gomez, Carolina Cavalieri Gomes, Marina Gonçalves Diniz
OBJECTIVES: The odontogenic keratocyst (OKC) is an aggressive odontogenic cyst that has a high recurrence rate. Apart from PTCH1 mutations, few molecular alterations are described in OKCs. Low expression of microRNAs (miRNAs) miR-15a and/or miR-16-1 in association with increased expression of their target, Bcl-2, have been previously found in OKC. In humans, MIR15A and MIR16-1 are clustered at chromosome position 13 q14, and loss of heterozygosity (LOH) at this locus occurs in different tumors...
April 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29415809/expression-profile-of-polycomb-group-proteins-in-odontogenic-keratocyst-and-ameloblastoma
#14
Puangwan Lapthanasupkul, Rachai Juengsomjit, Sopee Poomsawat, Tawepong Arayapisit
Polycomb group (PcG) proteins are repressive chromatin modifiers required for proliferation and development. PcG proteins form two large repressive complexes, namely, Polycomb Repressive Complex 1 and 2. These proteins have been shown to drive tumorigenesis by repressing cell-type specific sets of target genes. Using immunohistochemistry, we investigated the expression patterns of five human PcG proteins, including Bmi-1, Ring1b, Mel-18, Ezh2, and Suz12, in various cellular components of odontogenic keratocysts (OKCs), ameloblastomas and, pericoronal follicles (PFs)...
April 2018: Acta Histochemica
https://www.readbyqxmd.com/read/29414392/spatial-distribution-of-osteopontin-cd44v6-and-podoplanin-in-the-lining-epithelium-of-odontogenic-keratocyst-and-their-biological-relevance
#15
Khamisah Awang Kechik, Chong Huat Siar
BACKGROUND AND AIMS: The odontogenic keratocyst (OKC) remains the most challenging jaw cyst to treat because of its locally-aggressive behaviour and high recurrence potential. Emerging evidence suggests that osteopontin, its receptors CD44v6 and integrin αv , and podoplanin, have a role in the local invasiveness of this cyst. However the spatial distribution characteristics of these pro-invasive markers in the lining epithelium of OKC, and their association with the clinicopathologic parameters of OKC are largely unexplored...
February 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29391734/quantitative-assessment-of-silver-stained-nucleolar-organizer-region-in-odontogenic-cysts-to-correlate-the-growth-and-malignant-potentiality
#16
Sailendra Nath Biswas, R R Paul, Jay Gopal Ray, Sumit Majumdar, Divya Uppala
Context: The most common and important odontogenic cyst involving jaws is the odontogenic keratocyst (OKC) or primordial cyst, the dentigerous cyst and the radicular cyst. These cysts all though do not show similar behavior, they all have the potentiality to recur. Silver nitrate staining of the nucleolar organizer regions (AgNORs) of the benign and malignant lesions is becoming very useful as a diagnostic indicator. Thus, the aim of this study is to assess the diagnostic potential of AgNORs in the cystic epithelium of common odontogenic cysts...
September 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29391732/a-comparative-study-of-odontogenic-keratocyst-and-orthokeratinized-odontogenic-cyst-using-ki67-and-%C3%AE-smooth-muscle-actin
#17
Vinay Kumar Dandena, Satish Yadava Thimmaiah, Mohammad Asif Kiresur, Prahlad Hunsigi, Swathi Roy, M Rashmi
Aim: This study aimed to demonstrate and evaluate the expression of stromal myofibroblasts (MFs) and epithelial cell proliferation using α-smooth muscle actin (α-SMA) and Ki67 markers, respectively, in odontogenic keratocyst (OKC) and orthokeratinized odontogenic cyst (OOC) to correlate their aggressive behavior. Materials and Methods: Twenty cases of OKC and twenty cases of OOC were stained with α-SMA and Ki67 markers for demonstration of stromal MFs and epithelial cell proliferation, respectively, and ten cases of well-differentiated squamous cell carcinoma were used as positive control...
September 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29391711/immunohistochemical-evaluation-of-inducible-nitric-oxide-synthase-in-the-epithelial-lining-of-odontogenic-cysts-a-qualitative-and-quantitative-analysis
#18
B K Akshatha, Karpagaselvi Karuppiah, G S Manjunath, Jayalakshmi Kumarswamy, Lokesh Papaiah, Jyothi Rao
Introduction: The three common odontogenic cysts include radicular cysts (RCs), dentigerous cysts (DCs), and odontogenic keratocysts (OKCs). Among these 3 cysts, OKC is recently been classified as benign keratocystic odontogenic tumor attributing to its aggressive behavior, recurrence rate, and malignant potential. The present study involved qualitative and quantitative analysis of inducible nitric oxide synthase (iNOS) expression in epithelial lining of RCs, DCs, and OKCs, compare iNOS expression in epithelial linings of all the 3 cysts and determined overexpression of iNOS in OKCs which might contribute to its aggressive behavior and malignant potential...
September 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29239923/primary-closure-of-oroantral-communication-using-pedicled-buccal-fat-pad-following-maxillary-cyst-enucleation
#19
Yusuf Emes, Uğur Aga, Anil Cesur, Merva Soluk-Tekkesin, Büket Aybar, Canan Alatli
Odontogenic keratocyst (OKC) is a clinically aggressive developmental odontogenic cyst with a high recurrence rate as 62%. Oroantral communication (OAC) is a gateway through the maxillary sinus and the oral cavity, which, if not treated, will develop into oroantral fistula or chronical sinus diseases. Different methods for closure of OAC were described but only few of them have common usage. In recent years, the use of a pedicled buccal fat pad (BFP) in closure of large oroantral defects has been become popular...
March 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29208793/assessment-of-proliferative-potential-of-odontogenic-keratocyst-and-dentigerous-cyst-using-podoplanin-an-immunohistochemical-study
#20
Sandeep Gupta, Aparna Paliwal, Nidhi Choudaha, Anish Gupta, Prashant Rao, Shekhar Grover
INTRODUCTION: Odontogenic cysts are commonly encountered lesions among head and neck pathologies. Odontogenic keratocyst (OKC) has unique features of recurrence and local aggressiveness. Podoplanin (PDP) is a lymphatic endothelial marker and is shown to be expressed in a variety of tissues. Hence, we planned to assess the significance of PDP in OKC and dentigerous cyst (DC). MATERIALS AND METHODS: The present study included assessment of immunoexpression of PDP in OKC and DC...
December 1, 2017: Journal of Contemporary Dental Practice
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